HUP9801177A2 - Tetrahidronaftil-, indanil- és indolilcsoporttal helyettesített pirido[2,3-d]pirimidin- és purinszármazékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények - Google Patents
Tetrahidronaftil-, indanil- és indolilcsoporttal helyettesített pirido[2,3-d]pirimidin- és purinszármazékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP9801177A2 HUP9801177A2 HU9801177A HUP9801177A HUP9801177A2 HU P9801177 A2 HUP9801177 A2 HU P9801177A2 HU 9801177 A HU9801177 A HU 9801177A HU P9801177 A HUP9801177 A HU P9801177A HU P9801177 A2 HUP9801177 A2 HU P9801177A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- atom
- hydrogen atom
- indanyl
- compounds
- Prior art date
Links
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 title abstract 2
- 125000001041 indolyl group Chemical group 0.000 title 1
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 title 1
- 159000000018 pyrido[2,3-d]pyrimidines Chemical class 0.000 title 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 239000000843 powder Substances 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 methylene- Chemical group 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 125000005329 tetralinyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 abstract 2
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/36—Sulfur atom
- C07D473/38—Sulfur atom attached in position 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A találmány őlyan (I) általánős képletű, új biciklűsős kőndenzáltpirimidinvegyületekre és gyógyászatilag elfőgadható sóikra vőnatkőzik,amelyek képletében X metilén-, -NH-(CH2)n-, -O-(CH2)n- vagy -S-(CH2)n-csőpőrt, n értéke 0vagy 1, A N-(R3)-szűbsztitűtált-4,5-kőndenzált-imidazőlgyűrű, ahől R3hidrőgénatőm, alkil- vagy benzilcsőpőrt, vagy A C-(R4)-szűbsztitűált-2,3-kőndenzált-piridingyűrű, ahől R4hidrőgénatőm, halőgénatőm, alkil-, alkőxi-, vagy -NR5R6-csőpőrt, R5 ésR6 hidrőgénatőm vagy alkilcsőpőrt, B tetralinil-, indanil- vagy 2-őxindőlil-csőpőrt, R1 és R2 hidrőgén-, halőgénatőm, alkil-, hidrőxi-, alkőxi-, alkőxi-karbőnil-, nitrő-, cianő- vagy triflűőr-metil-csőpőrt, azzal a megkötéssel, hőgy ha A piridingyűrű, B tetralinilcsőpőrt, R4hidrőgén-, halőgénatőm, alkil- vagy alkőxicsőpőrt, és X a fentiekbenmeghatárőzőtt, akkőr R1 és R2 hidrőgénatőmtól eltérő, és ha Aimidazőlgyűrű, X -NH-(CH2)n-csőpőrt és B adőtt esetben szűbsztitűáltindanilcsőpőrt, akkőr R3 alkil- vagy benzilcsőpőrttól eltérő. A találmány kiterjed a találmány szerinti vegyületek előállításieljárásaira, a vegyületeket tartalmazó gyógyszerkészítményekre és avegyületek alkalmazására, különösen tirőzin-kináz inhibitőr hatásúgyógyszerkészítmények előállítására. ŕ
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9523242.7A GB9523242D0 (en) | 1995-11-14 | 1995-11-14 | Aryl and heteroaryl purine compounds |
| GBGB9524131.1A GB9524131D0 (en) | 1995-11-24 | 1995-11-24 | Pyrido-pyrimidine compounds as tyrosine kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9801177A2 true HUP9801177A2 (hu) | 1998-09-28 |
| HUP9801177A3 HUP9801177A3 (en) | 1998-11-30 |
Family
ID=26308112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9801177A HUP9801177A3 (en) | 1995-11-14 | 1996-10-14 | Tetrahydronaphthyl, indanyl and indolyl substituted pyrido[2,3-d]pyrimidine and purine derivatives, process for their preparation and pharmaceutical compositions containing them |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5965563A (hu) |
| EP (1) | EP0802914B1 (hu) |
| JP (1) | JPH10512896A (hu) |
| CN (1) | CN1168138A (hu) |
| AR (1) | AR004320A1 (hu) |
| AT (1) | ATE201873T1 (hu) |
| AU (1) | AU7292096A (hu) |
| BR (1) | BR9607089A (hu) |
| CA (1) | CA2209598C (hu) |
| DE (1) | DE69613211T2 (hu) |
| EA (1) | EA000072B1 (hu) |
| ES (1) | ES2159760T3 (hu) |
| HU (1) | HUP9801177A3 (hu) |
| IL (1) | IL121090A0 (hu) |
| NO (1) | NO973198D0 (hu) |
| PL (1) | PL321296A1 (hu) |
| WO (1) | WO1997018212A1 (hu) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| TW321649B (hu) * | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
| GB9424233D0 (en) * | 1994-11-30 | 1995-01-18 | Zeneca Ltd | Quinazoline derivatives |
| GB9508565D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
| GB9508535D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivative |
| US5932574A (en) * | 1995-04-27 | 1999-08-03 | Zeneca Limited | Quinazoline derivatives |
| GB9508537D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| GB9624482D0 (en) * | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| ATE237596T1 (de) | 1996-02-13 | 2003-05-15 | Astrazeneca Ab | Chinazolinderivate und deren verwendung als vegf hemmer |
| GB9603097D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline compounds |
| US6291455B1 (en) | 1996-03-05 | 2001-09-18 | Zeneca Limited | 4-anilinoquinazoline derivatives |
| NZ332119A (en) | 1996-04-12 | 2001-08-31 | Warner Lambert Co | Quinazoline compounds which are irreversible inhibitors of tyrosine kinases |
| HRP970371A2 (en) | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
| US5866702A (en) * | 1996-08-02 | 1999-02-02 | Cv Therapeutics, Incorporation | Purine inhibitors of cyclin dependent kinase 2 |
| ATE311884T1 (de) | 1997-07-12 | 2005-12-15 | Cancer Rec Tech Ltd | Cyclin-abhängige-kinase inhibierende purinderivate |
| RS49779B (sr) | 1998-01-12 | 2008-06-05 | Glaxo Group Limited, | Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze |
| PA8474101A1 (es) | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| WO1999065908A1 (en) | 1998-06-19 | 1999-12-23 | Pfizer Products Inc. | PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS |
| DE60037020T2 (de) | 1999-07-09 | 2008-08-21 | Glaxo Group Ltd., Greenford | Anilinochinazoline als protein-tyrosin-kinasehemmer |
| US6933299B1 (en) | 1999-07-09 | 2005-08-23 | Smithkline Beecham Corporation | Anilinoquinazolines as protein tyrosine kinase inhibitors |
| NZ518028A (en) | 1999-11-05 | 2004-03-26 | Astrazeneca Ab | Quinazoline derivatives as VEGF inhibitors |
| PT1235830E (pt) | 1999-12-10 | 2004-04-30 | Pfizer Prod Inc | Compostos de pirrolo¬2,3-d|pirimidina como inibidores das proteina cinases |
| SI1294724T1 (sl) | 2000-06-26 | 2006-08-31 | Pfizer Prod Inc | Pirolo(2,3-d)primidinske spojine kot imunosupresivna sredstva |
| US7301023B2 (en) | 2001-05-31 | 2007-11-27 | Pfizer Inc. | Chiral salt resolution |
| AU2002346729A1 (en) * | 2001-12-20 | 2003-07-09 | Bristol-Myers Squibb Company | Barbituric acid derivatives as inhibitors of tnf-$g(a) converting enzyme (tace) and/or matrix metalloproteinases |
| EP1352910A1 (en) * | 2002-04-10 | 2003-10-15 | Grünenthal GmbH | New analogs of nitrobenzylthioinosine |
| AU2003276591A1 (en) | 2002-11-26 | 2004-06-18 | Pfizer Products Inc. | Method of treatment of transplant rejection |
| BRPI0413563A (pt) * | 2003-08-15 | 2006-10-17 | Irm Llc | compostos e composições como inibidores de atividade do receptor de quìnase de tirosina |
| BRPI0507373A (pt) * | 2004-01-23 | 2007-07-10 | Amgen Inc | compostos e método de uso |
| WO2005073224A2 (en) | 2004-01-23 | 2005-08-11 | Amgen Inc | Quinoline quinazoline pyridine and pyrimidine counds and their use in the treatment of inflammation angiogenesis and cancer |
| DE602004009166T2 (de) * | 2004-06-29 | 2008-08-21 | Grünenthal GmbH | Neue Analoga von Nitrobenzylthioinosin |
| MX2007006230A (es) * | 2004-11-30 | 2007-07-25 | Amgen Inc | Quinolinas y analogos de quinazolinas y su uso como medicamentos para tratar cancer. |
| JO2787B1 (en) * | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| WO2007081517A2 (en) | 2005-12-21 | 2007-07-19 | Abbott Laboratories | Anti-viral compounds |
| AU2006330924B2 (en) * | 2005-12-21 | 2012-03-15 | Abbvie Inc. | Anti-viral compounds |
| TWI399380B (zh) * | 2006-12-20 | 2013-06-21 | Abbott Lab | 抗病毒化合物 |
| CA2703257C (en) * | 2007-10-29 | 2013-02-19 | Amgen Inc. | Benzomorpholine derivatives and methods of use |
| RU2493157C2 (ru) | 2008-08-20 | 2013-09-20 | Пфайзер Инк. | ПРОИЗВОДНЫЕ ПИРРОЛО[2,3-d]ПИРИМИДИНА |
| DE102011111400A1 (de) * | 2011-08-23 | 2013-02-28 | Merck Patent Gmbh | Bicyclische heteroaromatische Verbindungen |
| US9296757B2 (en) | 2012-05-21 | 2016-03-29 | Bayer Pharma Aktiengesellschaft | Substituted benzothienopyrimidines |
| TW201412740A (zh) | 2012-09-20 | 2014-04-01 | Bayer Pharma AG | 經取代之吡咯并嘧啶胺基苯并噻唑酮 |
| ES2686909B1 (es) | 2017-03-22 | 2019-08-16 | Consejo Superior Investigacion | Compuestos inhibidores de cdc-7 y su uso para el tratamiento de patologias neurologicas |
| FR3066761B1 (fr) * | 2017-05-23 | 2020-10-30 | Centre Nat Rech Scient | Nouveaux composes inhibiteurs des canaux ioniques |
| NL2022471B1 (en) | 2019-01-29 | 2020-08-18 | Vationpharma B V | Solid state forms of oclacitinib |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB828522A (en) * | 1956-11-02 | 1960-02-17 | Geigy Ag J R | Purine derivatives and a process for the preparation thereof |
| US3112192A (en) * | 1960-09-19 | 1963-11-26 | Shell Oil Co | Preservation of cut flowers |
| AU575438B2 (en) * | 1984-10-26 | 1988-07-28 | Warner-Lambert Company | N6 - substituted deoxyribose analogues of adenosines |
| US4751292A (en) * | 1985-07-02 | 1988-06-14 | The Plant Cell Research Institute, Inc. | Adamantyl purines |
| DE3529497A1 (de) * | 1985-08-17 | 1987-02-26 | Boehringer Mannheim Gmbh | N(pfeil hoch)6(pfeil hoch)-disubstituierte purinderivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| EP0457773A4 (en) * | 1989-01-31 | 1993-03-10 | Whitby Research Incorporated | N?6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists |
| US5034393A (en) * | 1989-07-27 | 1991-07-23 | Dowelanco | Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives |
| US5639752A (en) * | 1991-11-25 | 1997-06-17 | Pfizer Inc | Indole derivatives |
| US5670501A (en) * | 1994-09-01 | 1997-09-23 | Discovery Therapeutics, Inc. | N-substituted 9-alkyladenines |
-
1996
- 1996-10-14 AT AT96934673T patent/ATE201873T1/de not_active IP Right Cessation
- 1996-10-14 CA CA002209598A patent/CA2209598C/en not_active Expired - Fee Related
- 1996-10-14 WO PCT/EP1996/004460 patent/WO1997018212A1/en not_active Application Discontinuation
- 1996-10-14 CN CN96191448A patent/CN1168138A/zh active Pending
- 1996-10-14 PL PL96321296A patent/PL321296A1/xx unknown
- 1996-10-14 BR BR9607089A patent/BR9607089A/pt not_active Application Discontinuation
- 1996-10-14 IL IL12109096A patent/IL121090A0/xx unknown
- 1996-10-14 ES ES96934673T patent/ES2159760T3/es not_active Expired - Lifetime
- 1996-10-14 EP EP96934673A patent/EP0802914B1/en not_active Expired - Lifetime
- 1996-10-14 US US08/860,717 patent/US5965563A/en not_active Expired - Fee Related
- 1996-10-14 JP JP9518527A patent/JPH10512896A/ja not_active Ceased
- 1996-10-14 AU AU72920/96A patent/AU7292096A/en not_active Abandoned
- 1996-10-14 HU HU9801177A patent/HUP9801177A3/hu unknown
- 1996-10-14 DE DE69613211T patent/DE69613211T2/de not_active Expired - Fee Related
- 1996-10-14 EA EA199700107A patent/EA000072B1/ru not_active IP Right Cessation
- 1996-11-13 AR ARP960105153A patent/AR004320A1/es unknown
-
1997
- 1997-07-09 NO NO973198A patent/NO973198D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2209598C (en) | 2005-06-07 |
| EP0802914B1 (en) | 2001-06-06 |
| US5965563A (en) | 1999-10-12 |
| EA000072B1 (ru) | 1998-06-25 |
| CN1168138A (zh) | 1997-12-17 |
| EA199700107A1 (ru) | 1997-12-30 |
| EP0802914A1 (en) | 1997-10-29 |
| BR9607089A (pt) | 1997-11-11 |
| AU7292096A (en) | 1997-06-05 |
| CA2209598A1 (en) | 1997-05-22 |
| WO1997018212A1 (en) | 1997-05-22 |
| ES2159760T3 (es) | 2001-10-16 |
| NO973198L (no) | 1997-07-09 |
| IL121090A0 (en) | 1997-11-20 |
| PL321296A1 (en) | 1997-12-08 |
| HUP9801177A3 (en) | 1998-11-30 |
| MX9705010A (es) | 1997-10-31 |
| AR004320A1 (es) | 1998-11-04 |
| ATE201873T1 (de) | 2001-06-15 |
| DE69613211D1 (de) | 2001-07-12 |
| JPH10512896A (ja) | 1998-12-08 |
| DE69613211T2 (de) | 2001-11-15 |
| NO973198D0 (no) | 1997-07-09 |
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