HUP9802568A3 - Alkyl amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists and pharmaceutical compositions containing them - Google Patents

Alkyl amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists and pharmaceutical compositions containing them

Info

Publication number: HUP9802568A3
Authority: HU; Hungary
Prior art keywords: diones; pharmaceutical compositions; compositions containing; receptor antagonists; alkyl amine
Prior art date: 1995-06-07

Application number

HU9802568A

Other languages

English (en)

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-07

Filing date

1996-05-13

Publication date

2000-01-28

1996-05-13 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1999-03-29 Publication of HUP9802568A2 publication Critical patent/HUP9802568A2/hu

2000-01-28 Publication of HUP9802568A3 publication Critical patent/HUP9802568A3/hu

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrrole Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

HU9802568A 1995-06-07 1996-05-13 Alkyl amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists and pharmaceutical compositions containing them HUP9802568A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/474,876 US5654303A (en)	1995-06-07	1995-06-07	Alkyl amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists

Publications (2)

Publication Number	Publication Date
HUP9802568A2 HUP9802568A2 (hu)	1999-03-29
HUP9802568A3 true HUP9802568A3 (en)	2000-01-28

Family

ID=23885301

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
HU9900883A HUP9900883A3 (en)	1995-06-07	1996-05-13	Amino acid derivatives of substituted quinoxaline 2,3-dione derivatives as glutamate receptor antagonists
HU9802568A HUP9802568A3 (en)	1995-06-07	1996-05-13	Alkyl amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists and pharmaceutical compositions containing them

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
HU9900883A HUP9900883A3 (en)	1995-06-07	1996-05-13	Amino acid derivatives of substituted quinoxaline 2,3-dione derivatives as glutamate receptor antagonists

Country Status (24)

Country	Link
US (1)	US5654303A (hu)
EP (1)	EP0837854B1 (hu)
JP (1)	JPH11506725A (hu)
KR (1)	KR19990022481A (hu)
AT (1)	ATE229512T1 (hu)
AU (1)	AU716156B2 (hu)
BG (1)	BG63462B1 (hu)
CA (1)	CA2219755A1 (hu)
CZ (1)	CZ290899B6 (hu)
DE (1)	DE69625361T2 (hu)
DK (1)	DK0837854T3 (hu)
EA (1)	EA000762B1 (hu)
EE (1)	EE03683B1 (hu)
ES (1)	ES2187650T3 (hu)
HU (2)	HUP9900883A3 (hu)
MX (1)	MX9708431A (hu)
NO (1)	NO309088B1 (hu)
NZ (1)	NZ308318A (hu)
PL (1)	PL186764B1 (hu)
PT (1)	PT837854E (hu)
SK (1)	SK283181B6 (hu)
UA (1)	UA48183C2 (hu)
WO (1)	WO1996040651A1 (hu)
ZA (1)	ZA964760B (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1067387C (zh) *	1994-09-27	2001-06-20	山之内制药株式会社	1,2,3,4－四氢喹喔啉二酮衍生物
AU3133697A (en) *	1996-06-05	1998-01-05	Warner-Lambert Company	Amide derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
US6015800A (en) *	1997-09-03	2000-01-18	Warner-Lambert Company	Substituted quinoxaline-2-ones as glutamate receptor antagonists
IL125950A0 (en) *	1997-09-05	1999-04-11	Pfizer Prod Inc	Methods of administering ampa receptor antagonists to treat dyskinesias associated with dopamine agonist therapy
US6391922B1 (en)	1998-01-13	2002-05-21	Synchroneuron, Llc	Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders
US20040152694A1 (en) *	2003-02-04	2004-08-05	Istvan Kurucz	Methods and compositions for treating inflammatory disorders of the airways
EP2338492A1 (en)	2009-12-24	2011-06-29	Universidad del Pais Vasco	Methods and compositions for the treatment of alzheimer
CN110642798B (zh) *	2019-11-10	2020-07-24	湖南科技学院	一种n-取代-1,4-二氢-2,3-喹喔啉二酮化合物的绿色合成方法
WO2024229096A1 (en) *	2023-05-02	2024-11-07	Zywie, Llc	Modified forms of ambroxol for therapeutic use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3992378A (en) *	1973-12-26	1976-11-16	Eli Lilly And Company	Fluoralkyl quinoxadinediones
JPH05117276A (ja) *	1991-10-23	1993-05-14	Sumitomo Pharmaceut Co Ltd	新規な３環性キノキサリンジオン誘導体
JPH06228112A (ja) *	1993-02-05	1994-08-16	Yamanouchi Pharmaceut Co Ltd	（１ｈ，４ｈ）キノキサリン誘導体
TW260660B (hu) *	1993-04-22	1995-10-21	Sumitomo Pharma
ES2111930T3 (es) *	1993-05-13	1998-03-16	Neurosearch As	Antagonistas del acido amp y procedimientos de tratamiento con la ayuda de estos.
US5631373A (en) *	1993-11-05	1997-05-20	State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon	Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones

1995
- 1995-06-07 US US08/474,876 patent/US5654303A/en not_active Expired - Fee Related
1996
- 1996-05-13 SK SK1690-97A patent/SK283181B6/sk unknown
- 1996-05-13 AU AU57920/96A patent/AU716156B2/en not_active Ceased
- 1996-05-13 MX MX9708431A patent/MX9708431A/es not_active IP Right Cessation
- 1996-05-13 ES ES96914617T patent/ES2187650T3/es not_active Expired - Lifetime
- 1996-05-13 NZ NZ308318A patent/NZ308318A/en unknown
- 1996-05-13 PT PT96914617T patent/PT837854E/pt unknown
- 1996-05-13 CA CA002219755A patent/CA2219755A1/en not_active Abandoned
- 1996-05-13 EE EE9700338A patent/EE03683B1/xx not_active IP Right Cessation
- 1996-05-13 CZ CZ19973872A patent/CZ290899B6/cs not_active IP Right Cessation
- 1996-05-13 DK DK96914617T patent/DK0837854T3/da active
- 1996-05-13 WO PCT/US1996/006818 patent/WO1996040651A1/en not_active Application Discontinuation
- 1996-05-13 UA UA98010046A patent/UA48183C2/uk unknown
- 1996-05-13 AT AT96914617T patent/ATE229512T1/de not_active IP Right Cessation
- 1996-05-13 EP EP96914617A patent/EP0837854B1/en not_active Expired - Lifetime
- 1996-05-13 DE DE69625361T patent/DE69625361T2/de not_active Expired - Fee Related
- 1996-05-13 JP JP9500558A patent/JPH11506725A/ja not_active Ceased
- 1996-05-13 HU HU9900883A patent/HUP9900883A3/hu unknown
- 1996-05-13 HU HU9802568A patent/HUP9802568A3/hu unknown
- 1996-05-13 PL PL96323824A patent/PL186764B1/pl unknown
- 1996-05-13 EA EA199800008A patent/EA000762B1/ru not_active IP Right Cessation
- 1996-05-13 KR KR1019970708962A patent/KR19990022481A/ko not_active Ceased
- 1996-06-06 ZA ZA964760A patent/ZA964760B/xx unknown
1997
- 1997-11-27 BG BG102079A patent/BG63462B1/bg unknown
- 1997-12-05 NO NO975703A patent/NO309088B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATE229512T1 (de)	2002-12-15
DE69625361D1 (de)	2003-01-23
DK0837854T3 (da)	2003-03-31
CZ387297A3 (cs)	1998-05-13
PL186764B1 (pl)	2004-02-27
US5654303A (en)	1997-08-05
HUP9900883A2 (hu)	1999-09-28
SK283181B6 (sk)	2003-03-04
ES2187650T3 (es)	2003-06-16
DE69625361T2 (de)	2003-04-17
PL323824A1 (en)	1998-04-27
PT837854E (pt)	2003-03-31
HUP9802568A2 (hu)	1999-03-29
NO975703D0 (no)	1997-12-05
CA2219755A1 (en)	1996-12-19
AU716156B2 (en)	2000-02-17
JPH11506725A (ja)	1999-06-15
MX9708431A (es)	1998-02-28
KR19990022481A (ko)	1999-03-25
SK169097A3 (en)	1998-07-08
ZA964760B (en)	1997-01-08
AU5792096A (en)	1996-12-30
EA199800008A1 (ru)	1998-06-25
WO1996040651A1 (en)	1996-12-19
EE9700338A (et)	1998-06-15
UA48183C2 (uk)	2002-08-15
EP0837854A1 (en)	1998-04-29
NZ308318A (en)	2001-04-27
EA000762B1 (ru)	2000-04-24
EE03683B1 (et)	2002-04-15
CZ290899B6 (cs)	2002-11-13
NO309088B1 (no)	2000-12-11
BG102079A (en)	1998-11-30
HUP9900883A3 (en)	2001-02-28
NO975703L (no)	1997-12-05
EP0837854B1 (en)	2002-12-11
BG63462B1 (bg)	2002-02-28

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