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HUP9901118A2 - Cukorrészben módosított, rést tartalmazó oligonukleotidok - Google Patents

Cukorrészben módosított, rést tartalmazó oligonukleotidok

Info

Publication number
HUP9901118A2
HUP9901118A2 HU9901118A HUP9901118A HUP9901118A2 HU P9901118 A2 HUP9901118 A2 HU P9901118A2 HU 9901118 A HU9901118 A HU 9901118A HU P9901118 A HUP9901118 A HU P9901118A HU P9901118 A2 HUP9901118 A2 HU P9901118A2
Authority
HU
Hungary
Prior art keywords
cleozide
female
sugar
units
gapped oligonucleotides
Prior art date
Application number
HU9901118A
Other languages
English (en)
Inventor
Karl-Heinz Altmann
Phillip D. Cook
Pierre Martin
Brett P. Monia
Original Assignee
Isis Pharmaceuticals Inc.
Novartis Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc., Novartis Ag. filed Critical Isis Pharmaceuticals Inc.
Publication of HUP9901118A2 publication Critical patent/HUP9901118A2/hu
Publication of HUP9901118A3 publication Critical patent/HUP9901118A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A találmány tárgyát őlyan őligőnűkleőtidők szintézise és alkalmazásaiképezik, amelyek a velük kőmplementer szálat elhasító RNáz-H-aktivitást váltanak ki. A találmány szerint őligőnűkleőtidőkban anűkleőzidegységek közül legalább néhány nűkleázrezisztenssé van téve,legalább néhány őlyan szűbsztitűenst tartalmaz, amely azőligőnűkleőtidnak egy, vele kőmplementer nűkleinsavszálhőz történőhibridizációját teszi lehetővé, és legalább néhány nűkleőzidegység 2'-dezőxi-eritrő-pentőfűranőzil-cűkőrrészt tartalmaz. A találmányszerinti őligőnűkleőtidők előnyösen alkalmazhatók terápiás ésdiagnősztikai célőkra, tővábbá a kűtatásban reagensként. ŕ
HU9901118A 1996-02-14 1997-02-07 Sugar-modified gapped oligonucleotides HUP9901118A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1162096P 1996-02-14 1996-02-14

Publications (2)

Publication Number Publication Date
HUP9901118A2 true HUP9901118A2 (hu) 1999-07-28
HUP9901118A3 HUP9901118A3 (en) 2000-06-28

Family

ID=21751248

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901118A HUP9901118A3 (en) 1996-02-14 1997-02-07 Sugar-modified gapped oligonucleotides

Country Status (22)

Country Link
US (1) US6451991B1 (hu)
EP (1) EP0882061B1 (hu)
JP (1) JP4293636B2 (hu)
KR (1) KR19990082476A (hu)
CN (1) CN1214688A (hu)
AT (1) ATE267207T1 (hu)
AU (1) AU725262B2 (hu)
BR (1) BR9707529A (hu)
CA (2) CA2246229C (hu)
CZ (1) CZ243498A3 (hu)
DE (1) DE69729179T2 (hu)
DK (1) DK0882061T3 (hu)
ES (1) ES2221039T3 (hu)
HU (1) HUP9901118A3 (hu)
IL (1) IL125759A0 (hu)
NO (1) NO983718L (hu)
NZ (1) NZ331217A (hu)
PL (1) PL328563A1 (hu)
SK (1) SK109198A3 (hu)
TR (1) TR199801581T2 (hu)
WO (1) WO1997030067A1 (hu)
ZA (1) ZA971208B (hu)

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