HUP9903248A3 - Indazole derivatives and pharmaceutical compositions containing them with the effect of inhibitors of phosphodiesterase (pde) type iv and the production of tumor necrosis factor (tnf) - Google Patents

Indazole derivatives and pharmaceutical compositions containing them with the effect of inhibitors of phosphodiesterase (pde) type iv and the production of tumor necrosis factor (tnf)

Info

Publication number: HUP9903248A3
Authority: HU; Hungary
Prior art keywords: pde; phosphodiesterase; tnf; inhibitors; production
Prior art date: 1996-09-04

Application number

HU9903248A

Other languages

English (en)

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-04

Filing date

1997-08-25

Publication date

2000-07-28

1997-08-25 Application filed by Pfizer filed Critical Pfizer

2000-04-28 Publication of HUP9903248A2 publication Critical patent/HUP9903248A2/hu

2000-07-28 Publication of HUP9903248A3 publication Critical patent/HUP9903248A3/hu

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Virology (AREA)
Immunology (AREA)
Dermatology (AREA)
Hematology (AREA)
Obesity (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Tropical Medicine & Parasitology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Orthopedic Medicine & Surgery (AREA)
AIDS & HIV (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

HU9903248A 1996-09-04 1997-08-25 Indazole derivatives and pharmaceutical compositions containing them with the effect of inhibitors of phosphodiesterase (pde) type iv and the production of tumor necrosis factor (tnf) HUP9903248A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US2544696P	1996-09-04	1996-09-04

Publications (2)

Publication Number	Publication Date
HUP9903248A2 HUP9903248A2 (hu)	2000-04-28
HUP9903248A3 true HUP9903248A3 (en)	2000-07-28

Family

ID=21826124

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU9903248A HUP9903248A3 (en)	1996-09-04	1997-08-25	Indazole derivatives and pharmaceutical compositions containing them with the effect of inhibitors of phosphodiesterase (pde) type iv and the production of tumor necrosis factor (tnf)

Country Status (35)

Country	Link
US (1)	US6262040B1 (hu)
EP (1)	EP0931075A1 (hu)
JP (2)	JP3554337B2 (hu)
KR (1)	KR100338610B1 (hu)
CN (1)	CN1234031A (hu)
AP (1)	AP795A (hu)
AR (1)	AR008162A1 (hu)
AU (1)	AU724549B2 (hu)
BG (1)	BG64447B1 (hu)
BR (1)	BR9712005A (hu)
CA (1)	CA2264798A1 (hu)
CO (1)	CO4600636A1 (hu)
DZ (1)	DZ2303A1 (hu)
EA (1)	EA002113B1 (hu)
GT (1)	GT199700102A (hu)
HN (1)	HN1997000126A (hu)
HR (1)	HRP970478B1 (hu)
HU (1)	HUP9903248A3 (hu)
ID (1)	ID18157A (hu)
IL (1)	IL128642A0 (hu)
IS (1)	IS4979A (hu)
MA (1)	MA26439A1 (hu)
NO (1)	NO991048L (hu)
NZ (1)	NZ334213A (hu)
OA (1)	OA10985A (hu)
PA (1)	PA8437301A1 (hu)
PE (1)	PE107998A1 (hu)
PL (1)	PL332187A1 (hu)
SK (1)	SK27299A3 (hu)
TN (1)	TNSN97148A1 (hu)
TR (1)	TR199900481T2 (hu)
TW (1)	TW402595B (hu)
WO (1)	WO1998009961A1 (hu)
YU (1)	YU11299A (hu)
ZA (1)	ZA977903B (hu)

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US7601847B2 (en)	2004-10-26	2009-10-13	Wyeth	Preparation and purification of 4-(indazol-3-yl)phenols
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1997
- 1997-08-25 YU YU11299A patent/YU11299A/sh unknown
- 1997-08-25 EP EP97934678A patent/EP0931075A1/en not_active Withdrawn
- 1997-08-25 IL IL12864297A patent/IL128642A0/xx unknown
- 1997-08-25 NZ NZ334213A patent/NZ334213A/xx unknown
- 1997-08-25 KR KR1019997001779A patent/KR100338610B1/ko not_active Expired - Fee Related
- 1997-08-25 CN CN97199022A patent/CN1234031A/zh active Pending
- 1997-08-25 HU HU9903248A patent/HUP9903248A3/hu unknown
- 1997-08-25 EA EA199900183A patent/EA002113B1/ru not_active IP Right Cessation
- 1997-08-25 US US09/254,346 patent/US6262040B1/en not_active Expired - Fee Related
- 1997-08-25 PL PL97332187A patent/PL332187A1/xx unknown
- 1997-08-25 BR BR9712005A patent/BR9712005A/pt not_active Application Discontinuation
- 1997-08-25 JP JP51240998A patent/JP3554337B2/ja not_active Expired - Fee Related
- 1997-08-25 AU AU37813/97A patent/AU724549B2/en not_active Ceased
- 1997-08-25 SK SK272-99A patent/SK27299A3/sk unknown
- 1997-08-25 CA CA002264798A patent/CA2264798A1/en not_active Abandoned
- 1997-08-25 WO PCT/IB1997/001023 patent/WO1998009961A1/en not_active Application Discontinuation
- 1997-08-25 TR TR1999/00481T patent/TR199900481T2/xx unknown
- 1997-08-29 HN HN1997000126A patent/HN1997000126A/es unknown
- 1997-09-01 TW TW086112518A patent/TW402595B/zh not_active IP Right Cessation
- 1997-09-02 PE PE1997000777A patent/PE107998A1/es not_active Application Discontinuation
- 1997-09-02 AR ARP970104001A patent/AR008162A1/es unknown
- 1997-09-03 DZ DZ970153A patent/DZ2303A1/xx active
- 1997-09-03 ZA ZA977903A patent/ZA977903B/xx unknown
- 1997-09-03 TN TNTNSN97148A patent/TNSN97148A1/fr unknown
- 1997-09-03 PA PA19978437301A patent/PA8437301A1/es unknown
- 1997-09-03 ID IDP973065A patent/ID18157A/id unknown
- 1997-09-03 GT GT199700102A patent/GT199700102A/es unknown
- 1997-09-03 MA MA24783A patent/MA26439A1/fr unknown
- 1997-09-04 AP APAP/P/1997/001080A patent/AP795A/en active
- 1997-09-04 CO CO97051473A patent/CO4600636A1/es unknown
- 1997-09-04 HR HR970478A patent/HRP970478B1/xx not_active IP Right Cessation
1999
- 1999-02-16 IS IS4979A patent/IS4979A/is unknown
- 1999-02-22 BG BG103195A patent/BG64447B1/bg unknown
- 1999-03-01 OA OA9900046A patent/OA10985A/en unknown
- 1999-03-03 NO NO991048A patent/NO991048L/no unknown
2004
- 2004-03-23 JP JP2004083812A patent/JP2004217668A/ja active Pending

Also Published As

Publication number	Publication date
NO991048D0 (no)	1999-03-03
JP2004217668A (ja)	2004-08-05
BG64447B1 (en)	2005-02-28
BR9712005A (pt)	1999-08-24
IS4979A (is)	1999-02-16
NZ334213A (en)	2000-08-25
AR008162A1 (es)	1999-12-09
HN1997000126A (es)	1997-12-26
AP9701080A0 (en)	1997-10-31
CA2264798A1 (en)	1998-03-12
EA002113B1 (ru)	2001-12-24
CO4600636A1 (es)	1998-05-08
PE107998A1 (es)	1999-01-30
AP795A (en)	1999-12-28
MA26439A1 (fr)	2004-12-20
US6262040B1 (en)	2001-07-17
YU11299A (sh)	2001-07-10
KR100338610B1 (ko)	2002-05-27
TR199900481T2 (xx)	1999-06-21
TNSN97148A1 (fr)	2005-03-15
NO991048L (no)	1999-05-03
PL332187A1 (en)	1999-08-30
JP3554337B2 (ja)	2004-08-18
EA199900183A1 (ru)	1999-08-26
TW402595B (en)	2000-08-21
KR20000068421A (ko)	2000-11-25
CN1234031A (zh)	1999-11-03
WO1998009961A1 (en)	1998-03-12
HRP970478A2 (en)	1998-08-31
AU724549B2 (en)	2000-09-28
HRP970478B1 (en)	2002-10-31
JP2000502724A (ja)	2000-03-07
ID18157A (id)	1998-03-05
HUP9903248A2 (hu)	2000-04-28
DZ2303A1 (fr)	2002-12-28
BG103195A (en)	1999-09-30
ZA977903B (en)	1999-03-03
IL128642A0 (en)	2000-01-31
GT199700102A (es)	1999-02-25
PA8437301A1 (es)	1999-12-27
EP0931075A1 (en)	1999-07-28
AU3781397A (en)	1998-03-26
OA10985A (en)	2001-11-01
SK27299A3 (en)	2000-10-09

Publication	Publication Date	Title
HUP9903248A3 (en)	2000-07-28	Indazole derivatives and pharmaceutical compositions containing them with the effect of inhibitors of phosphodiesterase (pde) type iv and the production of tumor necrosis factor (tnf)
HUP9902459A3 (en)	2001-10-29	Substituted indazole derivatives and their use as inhibitors phosphodiesterase (pde) type iv and the production of tumor necrosis factor (tnf)
PL330974A1 (en)	1999-06-21	Substituted derivatives of indazole and their application as inhibitors of phosphodiesterase (pde) of iv type and of tumor necrosis factor (tnf)
NZ292991A (en)	1999-02-25	Bicyclic tetrahydropyrazolopyridines that are selective inhibitors of phosphodiesterase (pde) type iv or the production of tnf and pharmaceutical compositions containing them
AU3588693A (en)	1993-09-01	N-benzyloxamic acid, oxamate, and oxamide derivatives and their use as TNF and PDE IV inhibitors
HUP9901780A3 (en)	2001-01-29	Imid derivatives as phosphodiesterases and tnf inhibitors and pharmaceutical compositions containing them
HUP0201261A3 (en)	2003-12-29	Indole-type derivatives as inhibitors of p38 kinase and pharmaceutical compositions containing them
HUP0301005A3 (en)	2006-05-29	Pirrolotriazine inhibitors of kinases pharmaceutical compositions containing them and their use
AU3102697A (en)	1998-01-07	Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase
AP2002002392A0 (en)	2002-03-31	Indazole compounds and pharmaceutical compositions for inhibiting protein kinases and methods for their use
HUP0004490A3 (en)	2002-10-28	Substituted oxindole derivatives as protein tyrosine kinase and as protein serine/threoning kinase inhibitors and pharmaceutical compositions containing them
HUT66324A (en)	1994-11-28	Quinazoline derivatives as acetylcholinesterase inhibitors and pharmaceutical compositions containing them
HUP0000678A3 (en)	2001-11-28	Aminobenzophenones as inhibitors of interleukin and tnf, process for their preparation and pharmaceutical compositions containing the same
HUP9902026A3 (en)	2000-07-28	Use of bicyclic 4-aralkylaminopyrimidine derivatives for producing pharmaceutical compositions having tyrosine kinase inhibitor effect, novel bicicyclic 4-aralkylaminopirimidine derivatives and pharmaceutical compositions containing them
HUP0102646A3 (en)	2003-01-28	Phthalazine derivatives phosphodiesterase 4 inhibitors and pharmaceutical compositions containing the same
NZ217961A (en)	1990-06-26	Indole and indazole derivatives and pharmaceutical compositions thereof
AU4573793A (en)	1994-02-14	N-cycloalkylpiperazine derivatives, methods of obtaining them and pharmaceutical compositions containing them
AU642772B2 (en)	1993-10-28	Inhibitors for the formation of tumor necrosis factor, processes for the preparation thereof and the use thereof
IL105867A0 (en)	1993-10-20	Derivatives of substituted imidazo benzoxazin-1-one,their preparation and pharmaceutical compositions containing them
HK1026898A (en)	2000-12-29	Quinoline derivatives as pde iv and/or tnf inhibitors
PT934307E (pt)	2011-07-18	Compostos azabicíclicos substituídos e sua utilização como inibidores da produção de tnf e da fosfodiesterase do amp cíclico