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ID19422A - Piridina dan bifenil tersubstitusi - Google Patents

Piridina dan bifenil tersubstitusi

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Publication number
ID19422A
ID19422A IDP972662A ID972662A ID19422A ID 19422 A ID19422 A ID 19422A ID P972662 A IDP972662 A ID P972662A ID 972662 A ID972662 A ID 972662A ID 19422 A ID19422 A ID 19422A
Authority
ID
Indonesia
Prior art keywords
bifenyl
pyridina
substituted
substituted bifenyl
Prior art date
Application number
IDP972662A
Other languages
English (en)
Indonesian (id)
Inventor
Gunter Schmidt
Rolf Angerbauer
Arndt Brandes
Mathias Muller-Gliemann
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of ID19422A publication Critical patent/ID19422A/id

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    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30Oxygen atoms
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    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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Families Citing this family (153)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6613942B1 (en) 1997-07-01 2003-09-02 Novo Nordisk A/S Glucagon antagonists/inverse agonists
WO1999041237A1 (fr) * 1998-02-13 1999-08-19 G.D. Searle & Co. Pyridines substituees utiles pour inhiber l'activite de la proteine assurant le transfert de l'ester de cholesteryle
CN1215076C (zh) 1998-09-09 2005-08-17 症变治疗公司 新的果糖1,6-二磷酸酶的杂芳族抑制剂
US7258869B1 (en) 1999-02-08 2007-08-21 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
US7919109B2 (en) 1999-02-08 2011-04-05 Intarcia Therapeutics, Inc. Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
US6503949B1 (en) 1999-05-17 2003-01-07 Noro Nordisk A/S Glucagon antagonists/inverse agonists
CA2397554C (fr) 2000-01-21 2009-09-22 Novartis Ag Combinaisons comprenant des inhibiteurs de la dipeptidylpeptidase- iv et des agents antidiabetiques
US6562807B2 (en) 2000-06-23 2003-05-13 Novo Nordisk A/S Glucagon antagonists/inverse agonists
US7563774B2 (en) 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
DK1303490T3 (da) * 2000-07-14 2008-08-25 Hoffmann La Roche N-oxider som NK1-receptorantagoniskprodugs af 4-phenyl-pyridinderivater
US7115279B2 (en) 2000-08-03 2006-10-03 Curatolo William J Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors
US6706744B2 (en) 2000-11-17 2004-03-16 Novo Nordisk A/S Glucagon antagonists/inverse agonists
US6821960B2 (en) 2000-11-17 2004-11-23 Noyo Nordisk Pharmaceuticals, Inc. Glucagon antagonists/inverse agonists
AU2002223500A1 (en) 2000-11-17 2002-05-27 Novo-Nordisk A/S Glucagon antagonists/inverse agonists
EP1935885A3 (fr) * 2001-05-22 2008-10-15 Neurogen Corporation Ligands de récepteur d'hormones à concentration de mélanine : Analogues de pipérazine 1-benzyl-4-aryl substitué.
CA2448080A1 (fr) 2001-05-22 2002-11-28 Neurogen Corporation Ligands recepteurs de l'hormone de concentration de la melanine: analogues de 1-benzyl-4-aryl piperazine substituee
CA2448825C (fr) 2001-06-22 2009-08-11 Pfizer Products Inc. Compositions pharmaceutiques de produits d'adsorption de medicament amorphe
ES2333645T3 (es) 2001-06-22 2010-02-25 Bend Research, Inc. Composiciones farmaceuticas de dispersiones de medicamentos y polimeros neutros.
UA74912C2 (en) 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
US6740776B2 (en) 2001-07-16 2004-05-25 Novartis Ag Air oxidation of an aromatic aldehyde to an aromatic acid
US6881746B2 (en) 2001-12-03 2005-04-19 Novo Nordick A/S Glucagon antagonists/inverse agonists
AU2002361811A1 (en) 2001-12-19 2003-07-09 Atherogenics, Inc. 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders
WO2003053368A2 (fr) 2001-12-19 2003-07-03 Atherogenics, Inc. Derives de chalcone et leur utilisation dans le traitement de maladies
AR038375A1 (es) 2002-02-01 2005-01-12 Pfizer Prod Inc Composiciones farmaceuticas de inhibidores de la proteina de transferencia de esteres de colesterilo
ATE395044T1 (de) 2002-02-01 2008-05-15 Pfizer Prod Inc Pharmazeutische zusammensetzungen amorpher dispersionen von wirkstoffen und lipophiler mikrophasenbildender materialien
PL209734B1 (pl) * 2002-02-20 2011-10-31 Emisphere Tech Inc Preparat farmaceutyczny zawierający związek GLP-1 i czynnik dostarczający oraz jego zastosowanie
NZ532494A (en) 2002-08-30 2006-03-31 Japan Tobacco Inc Dibenzylamine compound and medicinal use thereof
US7196106B2 (en) 2002-11-05 2007-03-27 Merck & Co., Inc Cyanothiophene derivatives, compositions containing such compounds and methods of use
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
DE60323536D1 (de) 2002-12-20 2008-10-23 Pfizer Prod Inc Dosierungsform enthaltend einen cetp-hemmer und einen hmg-coa reduktase hemmer
US20040209928A1 (en) * 2002-12-30 2004-10-21 Ravi Kurukulasuriya Glucagon receptor antagonists/inverse agonists
RS20050532A (en) 2003-01-14 2007-12-31 Arena Pharmaceuticals Inc., 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prpphylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
EP1590336B1 (fr) 2003-01-27 2010-12-01 Merck Sharp & Dohme Corp. Pyrazoles substitues, compositions contenant de tels composes et procedes d'utilisation
US20070066590A1 (en) * 2003-02-24 2007-03-22 Jones Robert M Phenyl-and pyridylpiperidine-derivatives as modulators of glucose metabolism
BRPI0408466B8 (pt) 2003-03-17 2021-05-25 Japan Tobacco Inc composição farmacêutica e uso de inibidor de proteína de transferência de colesteril éster e crospovidona
WO2004082675A1 (fr) 2003-03-17 2004-09-30 Japan Tobacco Inc. Procede pour accroitre la biodisponibilite orale de s- [2- ([[1- (2-ethylbutyl) cyclohexyl] carbonyl] amino) phenyl] -2-methylpropanethioate
WO2004103310A2 (fr) * 2003-05-20 2004-12-02 New England Medical Center Hospitals, Inc. Procedes et compositions destinees au traitement de troubles metaboliques
AR045047A1 (es) * 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
CL2004001884A1 (es) 2003-08-04 2005-06-03 Pfizer Prod Inc Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros.
KR20070087197A (ko) 2003-09-26 2007-08-27 니뽄 다바코 산교 가부시키가이샤 잔여 리포프로테인 생산 저해 방법
RU2353617C2 (ru) * 2003-10-31 2009-04-27 Такеда Фармасьютикал Компани Лимитед Производные пиридина в качестве ингибиторов дипептидилпептидазы iv
PE20050444A1 (es) 2003-10-31 2005-08-09 Takeda Pharmaceutical Compuestos de piridina como inhibidores de la peptidasa
US7301036B2 (en) * 2003-12-19 2007-11-27 Merck & Co., Inc. Cyclic guanidines, compositions containing such compounds and methods of use
AU2004303602C1 (en) 2003-12-23 2009-05-28 Astex Therapeutics Limited Pyrazole derivatives as protein kinase modulators
ATE415397T1 (de) * 2004-06-04 2008-12-15 Arena Pharm Inc Substituierte aryl- und heteroarylderivate als modulatoren des stoffwechsels und für die prophylaxe und behandlung von damit in zusammenhang stehenden erkrankungen
EA012431B1 (ru) * 2004-06-04 2009-10-30 Мерк Энд Ко., Инк. Производные пиразола, фармацевтические композиции и их применение
DE602005017895D1 (de) * 2004-07-07 2010-01-07 Merck & Co Inc Pyrazolamid-derivate, diese verbindungen enthaltende zusammensetzungen und anwendungsverfahren
US7625938B2 (en) * 2004-07-22 2009-12-01 Merck & Co., Inc. Substituted pyrazoles, compositions containing such compounds and methods of use
US8604055B2 (en) 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
DK1848430T3 (da) 2004-12-31 2017-11-06 Dr Reddys Laboratories Ltd Nye benzylamin-derivativer som cetp-inhibitors
WO2006072881A1 (fr) 2005-01-10 2006-07-13 Cortendo Invest Ab Procedes et compositions pour le traitement du diabete, du syndrome metabolique et d'autres conditions
DOP2006000010A (es) 2005-01-10 2006-07-31 Arena Pharm Inc Procedimiento para preparar eteres aromáticos
MY148521A (en) * 2005-01-10 2013-04-30 Arena Pharm Inc Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
US8617604B2 (en) 2005-02-03 2013-12-31 Bend Research, Inc. Pharmaceutical compositions with enhanced performance
WO2006083761A2 (fr) 2005-02-03 2006-08-10 Alza Corporation Solutions de solvant/polymere utilisees comme vehicules de suspension
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
CN101146762A (zh) 2005-03-21 2008-03-19 默克公司 取代的芳基和杂芳基衍生物
EP1868985A4 (fr) 2005-03-30 2010-05-05 Merck Sharp & Dohme Composes antagonistes du recepteur du glucagon, compositions renfermant de tels composes et methodes d'utilisation
US8343953B2 (en) 2005-06-22 2013-01-01 Astex Therapeutics Limited Pharmaceutical compounds
US8541461B2 (en) 2005-06-23 2013-09-24 Astex Therapeutics Limited Pharmaceutical combinations comprising pyrazole derivatives as protein kinase modulators
CN1884278A (zh) * 2005-06-24 2006-12-27 中国科学院上海药物研究所 一类胰高血糖样肽-1受体调节剂、制备方法和用途
US7709658B2 (en) 2005-07-26 2010-05-04 Merck Sharp & Dohme Corp. Process for synthesizing a substituted pyrazole
CN102908350B (zh) 2005-09-14 2014-07-23 武田药品工业株式会社 用于治疗糖尿病的二肽基肽酶抑制剂
EA013084B1 (ru) * 2005-09-16 2010-02-26 Арена Фармасьютикалз, Инк. Модуляторы метаболизма и лечение связанных с ним нарушений
TW200745031A (en) 2005-10-13 2007-12-16 Merck & Co Inc Acyl indoles, compositions containing such compounds and methods of use
US7863329B2 (en) * 2005-11-17 2011-01-04 Eli Lilly And Company Glucagon receptor antagonists, preparation and therapeutic uses
EP1801098A1 (fr) 2005-12-16 2007-06-27 Merck Sante Dérivés de 2-Adamantylurea comme inhibiteurs de 11B-HSD1
CA2642130C (fr) * 2005-12-28 2013-04-02 Reddy Us Therapeutics, Inc. Derives de benzylamine selectifs et leur utilite en tant qu'inhibiteurs de la proteine de transfert de l'ester de cholesterol
DE102006012548A1 (de) 2006-03-18 2007-09-20 Bayer Healthcare Ag Substituierte Chromanol-Derivate und ihre Verwendung
CA2645639A1 (fr) 2006-03-23 2007-10-04 Merck & Co. Inc. Composes antagonistes du recepteur du glucagon, compositions contenant de tels composes et procedes d'utilisation
US7935713B2 (en) 2006-05-16 2011-05-03 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
ATE481963T1 (de) 2006-05-30 2010-10-15 Intarcia Therapeutics Inc Zweiteiliger flussmodulator mit einem internen kanal für ein osmotisches ausgabesystem
TW200811147A (en) * 2006-07-06 2008-03-01 Arena Pharm Inc Modulators of metabolism and the treatment of disorders related thereto
TW200811140A (en) * 2006-07-06 2008-03-01 Arena Pharm Inc Modulators of metabolism and the treatment of disorders related thereto
US7682356B2 (en) 2006-08-09 2010-03-23 Intarcia Therapeutics, Inc. Osmotic delivery systems and piston assemblies for use therein
JP2010502670A (ja) 2006-09-07 2010-01-28 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 真性糖尿病のための組合せ治療
BRPI0719835A2 (pt) 2006-10-02 2014-05-06 Cortendo Invest Ab Enantiômero de cetoconazol em humanos
TW200821284A (en) 2006-10-03 2008-05-16 Merck & Co Inc Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
EP1935420A1 (fr) 2006-12-21 2008-06-25 Merck Sante Dérivés du 2-adamantyl-butyramide en tant qu'inhibiteurs selectifs de la 11beta-HSD1
GB0704932D0 (en) 2007-03-14 2007-04-25 Astex Therapeutics Ltd Pharmaceutical compounds
CA2683610C (fr) 2007-04-23 2013-01-08 Intarcia Therapeutics, Inc. Formulations en suspension de peptides insulinotropes et leurs utilisations
JP2010530418A (ja) * 2007-06-20 2010-09-09 メルク・シャープ・エンド・ドーム・コーポレイション ベンゾオキサゾールアリールアミドから誘導されたcetp阻害剤
AU2008266954A1 (en) * 2007-06-20 2008-12-24 Merck Sharp & Dohme Corp. CETP inhibitors derived from benzoxazole arylamides
JP2010530417A (ja) * 2007-06-20 2010-09-09 メルク・シャープ・エンド・ドーム・コーポレイション ベンゾオキサゾールアリールアミドから誘導されたcetp阻害剤
WO2009102467A2 (fr) 2008-02-13 2009-08-20 Intarcia Therapeutics, Inc. Dispositifs, formulations et méthodes d’administration de plusieurs agents bénéfiques
EP2110374A1 (fr) 2008-04-18 2009-10-21 Merck Sante Dérivés de benzofurane, benzothiophène, benzothiazol en tant que modulateurs FXR
JO2870B1 (en) 2008-11-13 2015-03-15 ميرك شارب اند دوهم كورب Amino Tetra Hydro Pirans as Inhibitors of Peptide Dipeptide IV for the Treatment or Prevention of Diabetes
US8759539B2 (en) 2008-11-17 2014-06-24 Merck Sharp & Dohme Corp. Substituted bicyclic amines for the treatment of diabetes
US20120220567A1 (en) 2009-07-23 2012-08-30 Shipps Jr Gerald W Benzo-fused oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors
WO2011011506A1 (fr) 2009-07-23 2011-01-27 Schering Corporation Composés oxazépine spirocyclique en tant qu'inhibiteurs de la stéaroyl-coenzyme a delta-9 désaturase
WO2011019538A1 (fr) 2009-08-13 2011-02-17 Merck Sharp & Dohme Corp. Composés cyclopropyle substitués, compositions contenant de tels composés et procédés de traitement
KR20120092096A (ko) 2009-09-02 2012-08-20 머크 샤프 앤드 돔 코포레이션 당뇨병의 치료 또는 예방을 위한 디펩티딜 펩티다제-iv 억제제로서의 아미노테트라히드로피란
ES2650667T3 (es) 2009-09-28 2018-01-19 Intarcia Therapeutics, Inc Rápido establecimiento y/o terminación de la administración sustancial de fármaco en estado estacionario
WO2011041293A1 (fr) 2009-09-30 2011-04-07 Takeda Pharmaceutical Company Limited Dérivés pyrazolo [1, 5—a] pyrimidines comme inhibiteurs de kinase 1 régulatrice de signal d'apoptose
WO2011058193A1 (fr) 2009-11-16 2011-05-19 Mellitech Dérivés de [1,5]-diazocine
CN102791701B (zh) 2009-12-30 2014-02-12 深圳信立泰药业股份有限公司 作为二肽基肽酶iv(dpp-iv)抑制剂的3-(3-氨基哌啶-1-基)-5-氧代-1,2,4-三嗪衍生物
SG10201500639TA (en) 2010-01-27 2015-03-30 Arena Pharm Inc Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
US8802695B2 (en) 2010-02-03 2014-08-12 Takeda Pharmaceutical Company Limited Apoptosis signal-regulating kinase 1 inhibitors
EP2538783B1 (fr) 2010-02-22 2016-06-01 Merck Sharp & Dohme Corp. Aminotétrahydrothiopyranes substitués et dérivés de ceux-ci utilisés en tant qu'inhibiteurs de la dipeptidylpeptidase-iv dans le cadre du traitement du diabète
EP2571876B1 (fr) 2010-05-21 2016-09-07 Merck Sharp & Dohme Corp. Composés hétérocycliques substitués à sept chaînons en tant qu'inhibiteurs de la dipeptidyl-peptidase iv pour le traitement du diabète
US8742110B2 (en) 2010-08-18 2014-06-03 Merck Sharp & Dohme Corp. Spiroxazolidinone compounds
CA2812061A1 (fr) 2010-09-22 2012-03-29 Arena Pharmaceuticals, Inc. Modulateurs du recepteur gpr119 et traitement des troubles qui lui sont lies
JP2013540145A (ja) * 2010-10-21 2013-10-31 ウニベルシテート デス ザールランデス コルチゾール依存性疾患の治療用の選択的cyp11b1阻害剤
RU2013127611A (ru) 2010-12-23 2015-01-27 Пфайзер Инк. Модуляторы глюкагонового рецептора
AP3338A (en) 2011-02-08 2015-07-31 Pfizer Glucagon receptor modulator
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
JP6047144B2 (ja) 2011-04-08 2016-12-21 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. 置換シクロプロピル化合物、このような化合物を含有する組成物および処置方法
CA2837517A1 (fr) 2011-06-02 2012-12-06 Intervet International B.V. Derives d'imidazole
EP2720544B1 (fr) 2011-06-16 2016-12-21 Merck Sharp & Dohme Corp. Composés cyclopropylés substitués, compositions contenant de tels composés et procédés de traitement
ES2550345T3 (es) 2011-07-22 2015-11-06 Pfizer Inc. Moduladores del receptor de quinolinilglucagón
JP5964965B2 (ja) 2011-08-18 2016-08-03 ドクター レディズ ラボラトリーズ リミテッド コレステリルエステル転送タンパク質(cetp)インヒビターとしての置換複素環式アミン化合物
CN103958511A (zh) 2011-09-27 2014-07-30 雷迪博士实验室有限公司 作为胆固醇酯转移蛋白(CETP)抑制剂用于治疗动脉粥样硬化的5-苄基氨基甲基-6-氨基吡唑并[3,4-b]吡啶衍生物
US9422266B2 (en) 2011-09-30 2016-08-23 Merck Sharp & Dohme Corp. Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment
WO2013062838A1 (fr) 2011-10-24 2013-05-02 Merck Sharp & Dohme Corp. Composés de pipéridinyle substitués utilisés comme agonistes du récepteur gpr119
WO2013068328A1 (fr) 2011-11-07 2013-05-16 Intervet International B.V. Composés d'acide bicyclo[2.2.2]octan-1-ylcarboxylique comme inhibiteurs de la dgat-1
WO2013068439A1 (fr) 2011-11-09 2013-05-16 Intervet International B.V. Composés 4-amino-5-oxo-7,8-dihydropyrimido[5, 4 -f] [1, 4] oxazépine comme inhibiteurs de dgat1
CA2855009C (fr) 2011-11-15 2019-07-09 Merck Sharp & Dohme Corp. Composes de cyclopropyle substitues utiles a titre d'agonistes de gpr119
EP2814485A4 (fr) 2012-02-17 2015-08-26 Merck Sharp & Dohme Inhibiteurs de dipeptidyle peptidase-iv pour le traitement ou la prévention du diabète
WO2013155600A1 (fr) 2012-04-16 2013-10-24 Kaneq Pharma Dérivés de phosphonates aromatiques fusionnés utilisés comme précurseurs d'inhibiteurs de ptp-1b
EP2874622A4 (fr) 2012-07-23 2015-12-30 Merck Sharp & Dohme Traitement du diabète par administration d'inhibiteurs de dipeptidyl peptidase-iv
WO2014029723A1 (fr) * 2012-08-24 2014-02-27 F. Hoffmann-La Roche Ag Nouveaux dérivés de pyridine bicyclique
WO2015066252A1 (fr) 2013-11-04 2015-05-07 Merck Sharp & Dohme Corp. Composés antagonistes du récepteur du glucagon, compositions correspodantes et méthodes d'utilisation
WO2015068156A1 (fr) 2013-11-05 2015-05-14 Ben-Gurion University Of The Negev Research And Development Authority Composés pour le traitement du diabète et des complications pathologiques qui en résultent
US10065945B2 (en) 2014-01-24 2018-09-04 Merck Sharp & Dohme Corp. Isoquinoline derivatives as MGAT2 inhibitors
RU2696588C2 (ru) 2014-04-17 2019-08-05 Мерк Шарп И Доум Корп. Комплекс танната ситаглиптина
ES2886641T3 (es) 2014-08-11 2021-12-20 Angion Biomedica Corp Inhibidores de citocromo P450 y sus usos
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
WO2016065090A1 (fr) 2014-10-24 2016-04-28 Merck Sharp & Dohme Corp. Co-agonistes des récepteurs du glucagon et du glp-1
WO2016109492A1 (fr) 2014-12-31 2016-07-07 Angion Biomedica Corp Méthodes et agents pour traiter une maladie
UA126268C2 (uk) 2015-01-06 2022-09-14 Арена Фармасьютікалз, Інк. СПОСОБИ ЛІКУВАННЯ СТАНІВ, ПОВ'ЯЗАНИХ З РЕЦЕПТОРОМ S1P<sub>1 </sub>
ES2968262T3 (es) 2015-06-03 2024-05-08 I2O Therapeutics Inc Sistemas de colocación de implantes
DK3310760T3 (da) 2015-06-22 2022-10-24 Arena Pharm Inc Krystallinsk L-argininsalt af (R)-2-(7-(4-cyclopentyl-3-(trifluormethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3- yl)eddikesyre til anvendelse ved S1P1-receptor-associerede lidelser
WO2017062334A1 (fr) 2015-10-05 2017-04-13 Merck Sharp & Dohme Corp. Conjugués anticorps-peptides ayant une activité agoniste au niveau des récepteurs au glucagon et au peptide-1 similaire au glucagon
EP3458084B1 (fr) 2016-05-16 2020-04-01 Intarcia Therapeutics, Inc Polypeptides sélectifs pour le récepteur du glucagon et méthodes pour leur utilisation
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
JP6994496B2 (ja) * 2016-07-05 2022-01-14 グアンジョウ マキシノベル ファーマシューティカルズ カンパニー リミテッド 芳香族アセチレンまたは芳香族エチレン系化合物、その中間体、製造方法、薬物組成物および使用
WO2018034917A1 (fr) 2016-08-15 2018-02-22 Merck Sharp & Dohme Corp. Composés utiles pour modifier les taux d'acides biliaires pour le traitement du diabète et de maladies cardiométaboliques.
US10414774B2 (en) 2016-08-15 2019-09-17 Merck Sharp & Dohme Corp. Compound useful for altering the levels of bile acids for the treatment of diabetes and cardiometabolc disease
MX2019008006A (es) 2017-01-03 2019-08-29 Intarcia Therapeutics Inc Metodos que comprenden la administracion continua de un agonista del receptor de glp-1 y la co-administracion de un farmaco.
US11534424B2 (en) 2017-02-16 2022-12-27 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
CN109988144B (zh) 2017-12-29 2024-07-05 广州再极医药科技有限公司 芳香乙烯或芳香乙基类衍生物、其制备方法、中间体、药物组合物及应用
CN108558847A (zh) * 2018-05-31 2018-09-21 马文军 一种酯类衍生物及其在防治心脑血管疾病中的应用
MX2020013157A (es) 2018-06-06 2021-04-29 Arena Pharm Inc Métodos de tratamiento de afecciones relacionadas con el receptor s1p1.
CN108484573B (zh) * 2018-06-26 2019-10-29 王先化 一种吲哚类衍生物及其在糖尿病中的应用
CN110833550B (zh) * 2018-08-15 2023-03-24 广西梧州制药(集团)股份有限公司 吡唑并嘧啶衍生物在治疗急性胰腺炎致肝损伤的用途
WO2020074958A1 (fr) 2018-10-12 2020-04-16 Strongbridge Dublin Limited Lévokétoconazole pour le traitement de l'hyperplasie surrénale congénitale et de l'aldostéronisme primaire
WO2020205688A1 (fr) 2019-04-04 2020-10-08 Merck Sharp & Dohme Corp. Inhibiteurs d'histone désacétylase -3 utiles pour le traitement du cancer, de l'inflammation, de maladies neurodégénératives et du diabète
EP3842449A1 (fr) 2019-12-23 2021-06-30 Merck Sharp & Dohme Corp. Co-agonistes d'oléfine agrafés du glucagon et récepteurs glp-1
EP3842061A1 (fr) 2019-12-23 2021-06-30 Merck Sharp & Dohme Corp. Co-agonistes triazoles agrafés des récepteurs du glucagon et du glp-1
EP3842060A1 (fr) 2019-12-23 2021-06-30 Merck Sharp & Dohme Corp. Co-agonistes lactames agrafés des récepteurs du glucagon et du glp-1
CN116077492B (zh) * 2023-02-07 2024-03-15 华中科技大学协和深圳医院 胰高血糖素受体拮抗剂-3用于制备抗革兰氏阳性菌感染药物中的应用
CN116262722A (zh) * 2023-03-21 2023-06-16 青岛科技大学 一种多取代1,2,3,4-四氢吡啶-2-醇类化合物的合成方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169857A (en) 1988-01-20 1992-12-08 Bayer Aktiengesellschaft 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis
ES8506627A1 (es) 1983-08-11 1985-08-01 Monsanto Co Un procedimiento para preparar derivados de piridina sustituidos en las posiciones 2 y 6
US4655816A (en) 1984-11-06 1987-04-07 Monsanto Company Herbicidal 2-trifluoromethyl 3-pyridine carboxylic acid derivatives
US4698093A (en) 1984-11-06 1987-10-06 Monsanto Company Herbicidal (2 or 6)-fluoroalkyl-4-amino pyridine derivatives
JPH0778059B2 (ja) 1986-03-11 1995-08-23 ダイセル化学工業株式会社 ピロン−3−カルボキサミド誘導体及び除草剤
NO881411L (no) 1987-04-14 1988-10-17 Bayer Ag Substituerte pyrroler.
DE3817808A1 (de) 1987-07-21 1989-02-02 Bayer Ag Verfahren zur herstellung von 2-substituierten pyrrolen
US4906624A (en) * 1987-09-08 1990-03-06 Warner-Lambert Company 6-(((Substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
US4997837A (en) 1987-09-08 1991-03-05 Warner-Lambert Company 6-(((substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
NO177005C (no) * 1988-01-20 1995-07-05 Bayer Ag Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen
NO890046L (no) * 1988-01-20 1989-07-21 Bayer Ag Disubstituerte pyridiner.
NO890522L (no) 1988-02-25 1989-08-28 Bayer Ag Substituerte imidazolinoner og imidazolinthioner.
NO890521L (no) 1988-02-25 1989-08-28 Bayer Ag Substituerte pyrimidiner.
DD283612A5 (de) 1988-02-25 1990-10-17 Bayer Aktiengesellschaft,De Verfahren zur herstellung von substituierten imidazolinonen und imidazolinthionen
NO890988L (no) 1988-03-24 1989-09-25 Bayer Ag Disubstituerte pyrroler.
EP0339342A1 (fr) 1988-04-23 1989-11-02 Bayer Ag N-aminopyrrols N-substitués
EP0352575A3 (fr) 1988-07-28 1991-08-21 Bayer Ag Pyrroles annelés substitués
US5164506A (en) 1988-12-14 1992-11-17 Bayer Aktiengesellschaft Substituted 2-pyridones and pyrid-2-thiones compounds
US5032602A (en) 1988-12-14 1991-07-16 Bayer Aktiengesellschaft Inhibiting HMG-CoA reductase with novel substituted 2-pyridones and pyrid-2-thiones
AU618158B2 (en) 1989-01-07 1991-12-12 Bayer Aktiengesellschaft New substituted pyrido(2,3-d)pyrimidines
DE3905908A1 (de) 1989-02-25 1990-09-06 Bayer Ag Substituierte chinoline, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE3909378A1 (de) 1989-03-22 1990-09-27 Bayer Ag Substituierte biphenyle
DE3911064A1 (de) 1989-04-06 1990-10-11 Bayer Ag Substituierte 1,8-naphthyridine
US5145959A (en) 1989-07-18 1992-09-08 Bayer Aktiengesellschaft Substituted pyrido (2,3-d) pyrimidines as intermediates
US5183897A (en) 1989-08-03 1993-02-02 Bayer Aktiengesellschaft Certain intermediate imino-substituted pyridines
US5072023A (en) 1990-02-15 1991-12-10 E. R. Squibb & Sons, Inc. Process for preparing highly substituted phenyls
NZ237097A (en) * 1990-02-26 1993-12-23 Squibb & Sons Inc Pyridine derivatives substituted in the 3-position by a phosphinic moiety.
DE4022414A1 (de) 1990-07-13 1992-01-16 Bayer Ag Substituierte pyrrolo-pyridine
DE4023308A1 (de) 1990-07-21 1992-01-23 Bayer Ag Substituierte pyrido-oxazine
DE4244029A1 (de) * 1992-12-24 1994-06-30 Bayer Ag Neue substituierte Pyridine
EP0742208A1 (fr) * 1995-05-05 1996-11-13 Grelan Pharmaceutical Co., Ltd. Dérivés de 2-ureido-benzamide
DE19610932A1 (de) * 1996-03-20 1997-09-25 Bayer Ag 2-Aryl-substituierte Pyridine

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HUP0100324A2 (hu) 2001-05-28
CN1239474A (zh) 1999-12-22
BG103200A (en) 1999-11-30
AR037300A2 (es) 2004-11-03
EP0934274A1 (fr) 1999-08-11
CA2262434A1 (fr) 1998-02-05
NO990399L (no) 1999-03-29
PL333465A1 (en) 1999-12-20
KR20000029723A (ko) 2000-05-25
WO1998004528A2 (fr) 1998-02-05
JP2001512416A (ja) 2001-08-21
AU3897197A (en) 1998-02-20
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HRP970425A2 (en) 1998-08-31
US6218431B1 (en) 2001-04-17
NO990399D0 (no) 1999-01-28
HUP0100324A3 (en) 2001-06-28
NO314143B1 (no) 2003-02-03
NZ333951A (en) 2000-09-29
BR9710637A (pt) 2000-10-31
CZ30899A3 (cs) 1999-05-12
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ZA976730B (en) 1999-07-29
AR008789A1 (es) 2000-02-23

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