IL125177A0 - Novel benzo-1,3-dioxolyl- and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists - Google Patents

Novel benzo-1,3-dioxolyl- and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists

Info

Publication number: IL125177A0
Authority: IL; Israel
Prior art keywords: dioxolyl; endothelin antagonists; pyrrolidine derivatives; substituted pyrrolidine; novel benzo
Prior art date: 1996-02-13

Application number

IL12517797A

Other languages

English (en)

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-13

Filing date

1997-02-12

Publication date

1999-03-12

1997-02-12 Application filed by Abbott Lab filed Critical Abbott Lab

1999-03-12 Publication of IL125177A0 publication Critical patent/IL125177A0/xx

Links

102000002045 Endothelin Human genes 0.000 title 1
108050009340 Endothelin Proteins 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 title 1
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1
150000003235 pyrrolidines Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)

IL12517797A 1996-02-13 1997-02-12 Novel benzo-1,3-dioxolyl- and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists IL125177A0 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US60062596A	1996-02-13	1996-02-13
US79450697A	1997-02-04	1997-02-04
PCT/US1997/001936 WO1997030045A1 (en)	1996-02-13	1997-02-12	Novel benzo-1,3-dioxolyl- and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists

Publications (1)

Publication Number	Publication Date
IL125177A0 true IL125177A0 (en)	1999-03-12

Family

ID=27083659

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL12517797A IL125177A0 (en)	1996-02-13	1997-02-12	Novel benzo-1,3-dioxolyl- and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists
IL125177A IL125177A (en)	1996-02-13	1998-07-01	Pyrolidine derivatives converted to benzo - 3,1 - dioxaolyl - and benzopuranil, their preparation and pharmaceutical compounds containing them

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL125177A IL125177A (en)	1996-02-13	1998-07-01	Pyrolidine derivatives converted to benzo - 3,1 - dioxaolyl - and benzopuranil, their preparation and pharmaceutical compounds containing them

Country Status (17)

Country	Link
EP (2)	EP1609790A3 (xx)
JP (1)	JP2002504081A (xx)
KR (1)	KR100508200B1 (xx)
CN (2)	CN1091768C (xx)
AR (1)	AR006309A1 (xx)
AT (1)	ATE323697T1 (xx)
AU (1)	AU2262097A (xx)
BR (1)	BR9707509A (xx)
CA (2)	CA2634973A1 (xx)
CZ (1)	CZ296660B6 (xx)
DE (1)	DE69735710T2 (xx)
DK (1)	DK0885215T3 (xx)
ES (1)	ES2259803T3 (xx)
IL (2)	IL125177A0 (xx)
NZ (1)	NZ330818A (xx)
PT (1)	PT885215E (xx)
WO (1)	WO1997030045A1 (xx)

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* Cited by examiner, † Cited by third party
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US7208517B1 (en)	1994-08-19	2007-04-24	Abbott Labortories	Endothelin antagonists
DE19743681A1 (de) *	1997-10-02	1999-04-08	Knoll Ag	Methode zur Verhinderung der Transplantatabstoßung
US6410554B1 (en)	1998-03-23	2002-06-25	Merck & Co., Inc.	Combination therapy for the treatment of benign prostatic hyperplasia
WO2000004179A1 (en) *	1998-07-15	2000-01-27	Bristol-Myers Squibb Company	Stereoselective reductive amination of ketones
JP2002524546A (ja) *	1998-09-14	2002-08-06	アボット・ラボラトリーズ	立体選択性ニトロ化合物の製造方法
TWI306760B (en) *	2000-08-07	2009-03-01	Abbott Lab	Use of an endothelin et-a receptor antagonist and orally delivered pharmaceutical composition comprising the same
WO2002017912A1 (en) *	2000-08-31	2002-03-07	Abbott Laboratories	Endothelin antagonists
EP1601666A2 (en)	2002-07-02	2005-12-07	Schering Corporation	New neuropeptide y y5 receptor antagonists
FR2874015B1 (fr) *	2004-08-05	2006-09-15	Sanofi Synthelabo	Derives de n-(1h-indolyl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
FR2880625B1 (fr) *	2005-01-07	2007-03-09	Sanofi Aventis Sa	Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
US20090054473A1 (en)	2007-08-22	2009-02-26	Gilead Colorado, Inc.	Therapy for complications of diabetes
KR20100114018A (ko) *	2007-11-30	2010-10-22	바이엘 쉐링 파마 악티엔게젤샤프트	헤테로아릴-치환된 피페리딘
WO2011114103A1 (en)	2010-03-18	2011-09-22	Biolipox Ab	Pyrimidinones for use as medicaments
JO2998B1 (ar)	2010-06-04	2016-09-05	Amgen Inc	مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان
US9376425B2 (en)	2011-09-27	2016-06-28	Amgen, Inc.	Heterocyclic compounds as MDM2 inhibitors for the treatment of cancer
US11407721B2 (en)	2013-02-19	2022-08-09	Amgen Inc.	CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
JP6266659B2 (ja)	2013-02-28	2018-01-24	アムジエン・インコーポレーテツド	癌の治療のための安息香酸誘導体ｍｄｍ２阻害剤
EP2970237B1 (en)	2013-03-14	2017-09-27	Amgen Inc.	Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer
JOP20200296A1 (ar)	2013-06-10	2017-06-16	Amgen Inc	عمليات صنع وأشكال بلورية من mdm2 مثبط
CN109400567A (zh) *	2018-12-05	2019-03-01	华中药业股份有限公司	一种合成甘草素的方法
PH12022551456A1 (en)	2019-12-17	2023-10-23	Chinook Therapeutics Inc	Methods of treating iga nephropathy with atrasentan
CN116194449B (zh) *	2021-09-03	2024-07-26	深圳信立泰药业股份有限公司	一种内皮素a(eta)受体拮抗剂化合物及其制备方法和医药用途
CN117447453B (zh) *	2022-07-25	2025-09-30	深圳信立泰药业股份有限公司	一种内皮素a(eta)受体拮抗剂化合物可药用的盐晶型及其制备方法
CN119487020B (zh) *	2022-07-25	2025-10-03	深圳信立泰药业股份有限公司	一种内皮素a(eta)受体拮抗剂化合物的盐及其制备方法和医药用途
CN120302971A (zh)	2022-10-28	2025-07-11	奇努克治疗公司	使用内皮素受体拮抗剂和april结合抗体治疗iga肾病

Family Cites Families (3)

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FI942059L (fi) *	1991-11-05	1994-07-04	Smithkline Beecham Corp	Endoteliinireseptoreiden antagonisteja
AU4679793A (en) *	1992-07-17	1994-02-14	Smithkline Beecham Corporation	Endothelin receptor antagonists
AU711832B2 (en) *	1994-08-19	1999-10-21	Abbvie Bahamas Ltd.	Endothelin antagonists

1997
- 1997-02-12 CN CN97192184A patent/CN1091768C/zh not_active Expired - Lifetime
- 1997-02-12 AR ARP970100553A patent/AR006309A1/es unknown
- 1997-02-12 BR BR9707509A patent/BR9707509A/pt not_active IP Right Cessation
- 1997-02-12 PT PT97905816T patent/PT885215E/pt unknown
- 1997-02-12 DK DK97905816T patent/DK0885215T3/da active
- 1997-02-12 EP EP05106190A patent/EP1609790A3/en not_active Withdrawn
- 1997-02-12 NZ NZ330818A patent/NZ330818A/xx not_active IP Right Cessation
- 1997-02-12 ES ES97905816T patent/ES2259803T3/es not_active Expired - Lifetime
- 1997-02-12 CA CA002634973A patent/CA2634973A1/en not_active Abandoned
- 1997-02-12 CZ CZ0253798A patent/CZ296660B6/cs not_active IP Right Cessation
- 1997-02-12 AT AT97905816T patent/ATE323697T1/de not_active IP Right Cessation
- 1997-02-12 WO PCT/US1997/001936 patent/WO1997030045A1/en active IP Right Grant
- 1997-02-12 EP EP97905816A patent/EP0885215B1/en not_active Expired - Lifetime
- 1997-02-12 CA CA002245587A patent/CA2245587C/en not_active Expired - Fee Related
- 1997-02-12 AU AU22620/97A patent/AU2262097A/en not_active Abandoned
- 1997-02-12 JP JP52939797A patent/JP2002504081A/ja active Pending
- 1997-02-12 DE DE69735710T patent/DE69735710T2/de not_active Expired - Lifetime
- 1997-02-12 KR KR10-1998-0706247A patent/KR100508200B1/ko not_active Expired - Fee Related
- 1997-02-12 IL IL12517797A patent/IL125177A0/xx active IP Right Grant
1998
- 1998-07-01 IL IL125177A patent/IL125177A/en not_active IP Right Cessation
2002
- 2002-02-09 CN CN02104623A patent/CN1384100A/zh active Pending

Also Published As

Publication number	Publication date
DE69735710D1 (de)	2006-05-24
KR19990082514A (ko)	1999-11-25
BR9707509A (pt)	1999-07-27
CN1091768C (zh)	2002-10-02
CA2634973A1 (en)	1997-08-21
EP0885215B1 (en)	2006-04-19
AU2262097A (en)	1997-09-02
EP1609790A2 (en)	2005-12-28
CN1384100A (zh)	2002-12-11
CZ253798A3 (cs)	1999-07-14
WO1997030045A1 (en)	1997-08-21
IL125177A (en)	2007-12-03
CA2245587A1 (en)	1997-08-21
ATE323697T1 (de)	2006-05-15
CN1219172A (zh)	1999-06-09
DK0885215T3 (da)	2006-08-14
JP2002504081A (ja)	2002-02-05
NZ330818A (en)	2000-05-26
ES2259803T3 (es)	2006-10-16
EP0885215A1 (en)	1998-12-23
KR100508200B1 (ko)	2005-12-16
PT885215E (pt)	2006-08-31
DE69735710T2 (de)	2007-03-29
AR006309A1 (es)	1999-08-25
CA2245587C (en)	2008-12-30
CZ296660B6 (cs)	2006-05-17
EP1609790A3 (en)	2006-01-04

Publication	Publication Date	Title
IL125177A0 (en)	1999-03-12	Novel benzo-1,3-dioxolyl- and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists
AP9901572A0 (en)	1999-06-30	2-(Purin-9 yl)-tetrahydrofur-n-3,4-diol derivatives
ZA97927B (en)	1997-08-19	New substituted oxazolidinones.
ZA9811599B (en)	1999-08-17	Ortho-anthranilamide derivatives as anti-coagulants.
ZA992771B (en)	2002-04-18	Substituted tricyclics.
ZA991272B (en)	1999-08-18	Novel thiobenzamides.
ZA992191B (en)	1999-09-29	Piperidine derivatives.
IL126624A0 (en)	1999-08-17	3-descladinose-2, 3-anhydroerythromycin derivatives
ZA992072B (en)	1999-09-22	Substituted pyrroles.
ZA973024B (en)	1997-11-04	Ketoacid endothelin antagonists.
ZA979617B (en)	1998-05-21	Novel heterocyclic compounds.
ZA974953B (en)	1997-12-08	Substituted pyrazolylpyrazole derivatives.
ZA979670B (en)	1998-04-28	Piperazino derivatives as neurokinin antagonists.
AU2517299A (en)	1999-08-02	Substituted alpha,beta-anellated butyrolactones
ZA200101830B (en)	2002-06-05	Piperidine derivatives.
ZA988938B (en)	1999-10-05	Amorphous paroxetine composition.
CZ20012041A3 (cs)	2001-10-17	Benzofuranové deriváty
EP0986553A4 (en)	2000-12-27	DIHYDROPYRIMIDONE DERIVATIVES AS NPY ANTAGONISTS
ZA979781B (en)	1998-06-08	Piperidine derivatives.
IL125453A0 (en)	1999-03-12	4-(Benzo-1,3-dioxylyl)-pyrrolidine-3-carboxylic acid derivatives as endothelin antagonists
ZA979642B (en)	1998-04-28	Heterocyclic compounds, compositions and uses.
ZA200006118B (en)	2002-01-30	Novel composition.
ZA9710609B (en)	1998-06-23	Cement composition.
ZA979649B (en)	1998-04-28	Heterocyclic compounds, compositions and uses.
ZA979644B (en)	1998-04-28	Heterocyclic compounds, compositions and uses.

Legal Events

Date	Code	Title	Description
2008-04-13	FF	Patent granted
2008-07-09	KB20	Patent renewed for 20 years