IL127908A0 - Modified oligosaccharides - Google Patents
Modified oligosaccharidesInfo
- Publication number
- IL127908A0 IL127908A0 IL12790897A IL12790897A IL127908A0 IL 127908 A0 IL127908 A0 IL 127908A0 IL 12790897 A IL12790897 A IL 12790897A IL 12790897 A IL12790897 A IL 12790897A IL 127908 A0 IL127908 A0 IL 127908A0
- Authority
- IL
- Israel
- Prior art keywords
- modified oligosaccharides
- oligosaccharides
- modified
- Prior art date
Links
- 229920001542 oligosaccharide Polymers 0.000 title 1
- 150000002482 oligosaccharides Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96810527 | 1996-08-08 | ||
| EP96810526 | 1996-08-08 | ||
| EP96810636 | 1996-09-26 | ||
| PCT/EP1997/004279 WO1998006730A1 (en) | 1996-08-08 | 1997-08-06 | Modified oligosaccharides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL127908A0 true IL127908A0 (en) | 1999-11-30 |
Family
ID=27237868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12790897A IL127908A0 (en) | 1996-08-08 | 1997-08-06 | Modified oligosaccharides |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0920437A1 (xx) |
| JP (1) | JP2000516224A (xx) |
| KR (1) | KR20000029862A (xx) |
| CN (1) | CN1227563A (xx) |
| AR (1) | AR008283A1 (xx) |
| AU (1) | AU720381B2 (xx) |
| BR (1) | BR9711117A (xx) |
| CA (1) | CA2260854A1 (xx) |
| CO (1) | CO4900075A1 (xx) |
| CZ (1) | CZ39099A3 (xx) |
| ID (1) | ID18010A (xx) |
| IL (1) | IL127908A0 (xx) |
| NO (1) | NO990497L (xx) |
| NZ (1) | NZ334048A (xx) |
| PE (1) | PE99298A1 (xx) |
| PL (1) | PL331286A1 (xx) |
| SK (1) | SK15699A3 (xx) |
| TR (1) | TR199900245T2 (xx) |
| WO (1) | WO1998006730A1 (xx) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5888984A (en) * | 1994-05-12 | 1999-03-30 | Dermal Research Laboratories, Inc. | Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same |
| US8003782B1 (en) | 1999-02-01 | 2011-08-23 | Dermal Research Laboratories, Inc. | Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same |
| US7879824B2 (en) | 2001-07-31 | 2011-02-01 | Dermal Research Laboratories, Inc. | Methods of preventing or treating diseases and conditions using complex carbohydrates |
| AU2003245595A1 (en) * | 2002-07-03 | 2004-01-23 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis |
| ES2334220T3 (es) | 2002-10-11 | 2010-03-08 | Astellas Pharma Europe B.V. | Compuestos basados en glucosa con afinidad por la p-selectiva. |
| JP2007524658A (ja) * | 2003-11-19 | 2007-08-30 | グリコミメティクス， インコーポレイテッド | Ｅ−およびｐ−セレクチンの両方のための糖模倣物アンタゴニスト |
| WO2005051920A2 (en) | 2003-11-19 | 2005-06-09 | Glycomimetics, Inc. | Specific antagonist for both e- and p-selectins |
| US20090036386A1 (en) * | 2005-05-25 | 2009-02-05 | Glycomimetics, Inc | Heterobifunctional compounds for selectin inhibition |
| WO2007021721A2 (en) | 2005-08-09 | 2007-02-22 | Glycomimetics, Inc. | Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas |
| CN103626813B (zh) | 2005-09-02 | 2017-05-03 | 糖模拟物有限公司 | 异型双功能全选择素抑制剂 |
| NZ598863A (en) * | 2007-02-09 | 2013-11-29 | Glycomimetics Inc | Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines |
| WO2009073911A1 (en) | 2007-12-10 | 2009-06-18 | Mater Medical Research Institute | Treatment and prophylaxis |
| US8895510B2 (en) | 2008-04-08 | 2014-11-25 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
| US8921328B2 (en) | 2010-09-14 | 2014-12-30 | Glycomimetics, Inc. | E-selectin antagonists |
| BR112014014547B1 (pt) | 2011-12-22 | 2022-09-27 | Glycomimetics, Inc | Composto, composição e métodos de uso |
| JP6392773B2 (ja) | 2012-12-07 | 2018-09-19 | グリコミメティクス， インコーポレイテッド | 造血細胞の動員のためにｅ−セレクチンアンタゴニストを使用する化合物、組成物および方法 |
| PT3227310T (pt) | 2014-12-03 | 2019-11-06 | Glycomimetics Inc | Inibidores heterobifuncionais de e-selectinas e recetores de quimiocina cxcr4 |
| EP3405473A1 (en) | 2016-01-22 | 2018-11-28 | GlycoMimetics, Inc. | Glycomimetic inhibitors of pa-il and pa-iil lectins |
| US11291678B2 (en) | 2016-03-02 | 2022-04-05 | Glycomimetics, Inc | Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin |
| JP2019524791A (ja) | 2016-08-08 | 2019-09-05 | グリコミメティクス， インコーポレイテッド | Ｅ−セレクチンの阻害剤もしくはｃｘｃｒ４の阻害剤との、またはｅ−セレクチンおよびｃｘｃｒ４両方のヘテロ二機能性阻害剤とのｔ細胞チェックポイント阻害剤の組み合わせ |
| EP3522931A1 (en) | 2016-10-07 | 2019-08-14 | GlycoMimetics, Inc. | Highly potent multimeric e-selectin antagonists |
| WO2018169853A1 (en) | 2017-03-15 | 2018-09-20 | Glycomimetics, Inc. | Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists |
| WO2019108750A1 (en) | 2017-11-30 | 2019-06-06 | Glycomimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
| AU2018395417B2 (en) | 2017-12-29 | 2023-07-13 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| CN108299525B (zh) * | 2018-01-05 | 2021-03-26 | 佛山科学技术学院 | 路易斯寡糖-x的合成方法 |
| CA3091454A1 (en) | 2018-03-05 | 2019-09-12 | Glycomimetics, Inc. | Methods for treating acute myeloid leukemia and related conditions |
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| CN109762032A (zh) * | 2019-01-16 | 2019-05-17 | 天津科技大学 | 一种磺酸化路易斯x三糖及其合成方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993023031A1 (en) * | 1992-05-08 | 1993-11-25 | The Biomembrane Institute | Multivalent mimetics and peptide mimetics for blocking carbohydrate-dependent cellular interaction and for eliciting anticarbohydrate t-cell response |
| US5763413A (en) * | 1993-03-04 | 1998-06-09 | Mect Corporation | Lewis-associated compound, process for producing the same, and anti-inflammatory |
| SK141695A3 (en) * | 1993-05-14 | 1996-10-02 | Cytel Corp | Analogous compound sialyl lex, pharmaceutical agent containing this compound and method of preparation of lactoseammoniacal salt |
| CA2209084A1 (en) * | 1994-12-28 | 1996-07-04 | Hiroshi Miyauchi | Lewis x derivative and process for producing the same |
-
1997
- 1997-08-06 AR ARP970103580A patent/AR008283A1/es unknown
- 1997-08-06 EP EP97941916A patent/EP0920437A1/en not_active Withdrawn
- 1997-08-06 TR TR1999/00245T patent/TR199900245T2/xx unknown
- 1997-08-06 JP JP10509358A patent/JP2000516224A/ja active Pending
- 1997-08-06 AU AU43788/97A patent/AU720381B2/en not_active Ceased
- 1997-08-06 CN CN97197077A patent/CN1227563A/zh active Pending
- 1997-08-06 KR KR1019997001025A patent/KR20000029862A/ko not_active Withdrawn
- 1997-08-06 SK SK156-99A patent/SK15699A3/sk unknown
- 1997-08-06 WO PCT/EP1997/004279 patent/WO1998006730A1/en not_active Application Discontinuation
- 1997-08-06 NZ NZ334048A patent/NZ334048A/xx unknown
- 1997-08-06 CZ CZ99390A patent/CZ39099A3/cs unknown
- 1997-08-06 BR BR9711117-1A patent/BR9711117A/pt not_active Application Discontinuation
- 1997-08-06 PL PL97331286A patent/PL331286A1/xx unknown
- 1997-08-06 CA CA002260854A patent/CA2260854A1/en not_active Abandoned
- 1997-08-06 IL IL12790897A patent/IL127908A0/xx unknown
- 1997-08-07 PE PE1997000688A patent/PE99298A1/es not_active Application Discontinuation
- 1997-08-08 ID IDP972766A patent/ID18010A/id unknown
- 1997-08-08 CO CO97045596A patent/CO4900075A1/es unknown
-
1999
- 1999-02-03 NO NO990497A patent/NO990497L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PE99298A1 (es) | 1999-01-21 |
| JP2000516224A (ja) | 2000-12-05 |
| AU4378897A (en) | 1998-03-06 |
| AR008283A1 (es) | 1999-12-29 |
| PL331286A1 (en) | 1999-07-05 |
| KR20000029862A (ko) | 2000-05-25 |
| ID18010A (id) | 1998-02-19 |
| TR199900245T2 (xx) | 1999-05-21 |
| CN1227563A (zh) | 1999-09-01 |
| NO990497D0 (no) | 1999-02-03 |
| NO990497L (no) | 1999-03-24 |
| NZ334048A (en) | 2000-05-26 |
| CA2260854A1 (en) | 1998-02-19 |
| EP0920437A1 (en) | 1999-06-09 |
| SK15699A3 (en) | 1999-07-12 |
| AU720381B2 (en) | 2000-06-01 |
| BR9711117A (pt) | 1999-09-08 |
| CZ39099A3 (cs) | 1999-05-12 |
| CO4900075A1 (es) | 2000-03-27 |
| WO1998006730A1 (en) | 1998-02-19 |
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