IL128929A0 - Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase - Google Patents
Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferaseInfo
- Publication number
- IL128929A0 IL128929A0 IL12892997A IL12892997A IL128929A0 IL 128929 A0 IL128929 A0 IL 128929A0 IL 12892997 A IL12892997 A IL 12892997A IL 12892997 A IL12892997 A IL 12892997A IL 128929 A0 IL128929 A0 IL 128929A0
- Authority
- IL
- Israel
- Prior art keywords
- protein transferase
- inhibition
- farnesyl protein
- derivatives useful
- substituted
- Prior art date
Links
- 102000004357 Transferases Human genes 0.000 title abstract 2
- 108090000992 Transferases Proteins 0.000 title abstract 2
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 title abstract 2
- XYNHQVIVVBWVAG-UHFFFAOYSA-N 4h-cyclohepta[f]quinoline Chemical class C1=CC=CC=C2C3=CC=CNC3=CC=C21 XYNHQVIVVBWVAG-UHFFFAOYSA-N 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Indole Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Cosmetics (AREA)
- Confectionery (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71192596A | 1996-09-13 | 1996-09-13 | |
| PCT/US1997/015905 WO1998011099A1 (fr) | 1996-09-13 | 1997-09-11 | Derives substitues de la benzocycloheptapyridine servant a inhiber la farnesyl-proteine transferase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL128929A0 true IL128929A0 (en) | 2000-02-17 |
Family
ID=24860067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12892997A IL128929A0 (en) | 1996-09-13 | 1997-09-11 | Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0931079B1 (fr) |
| JP (1) | JP2001500508A (fr) |
| KR (1) | KR20000036103A (fr) |
| CN (1) | CN1122031C (fr) |
| AT (1) | ATE209201T1 (fr) |
| AU (1) | AU4337797A (fr) |
| BR (1) | BR9711477A (fr) |
| CA (1) | CA2264513C (fr) |
| CZ (1) | CZ87499A3 (fr) |
| DE (1) | DE69709774T2 (fr) |
| ES (1) | ES2163195T3 (fr) |
| HU (1) | HUP9904056A3 (fr) |
| ID (1) | ID22156A (fr) |
| IL (1) | IL128929A0 (fr) |
| NO (1) | NO991229L (fr) |
| NZ (1) | NZ334437A (fr) |
| PL (1) | PL332253A1 (fr) |
| SK (1) | SK33599A3 (fr) |
| TR (1) | TR199901205T2 (fr) |
| WO (1) | WO1998011099A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0989979A1 (fr) * | 1997-06-17 | 2000-04-05 | Schering Corporation | Nouveaux composes d'uree n-substitues inhibiteurs de la farnesyl transferase |
| US6358968B1 (en) | 1997-06-17 | 2002-03-19 | Schering Corporation | N-substituted urea inhibitors of farnesyl-protein transferase |
| AU2335699A (en) | 1998-01-21 | 1999-08-09 | Kyowa Hakko Kogyo Co. Ltd. | Chemokine receptor antagonists and methods of use therefor |
| ATE309249T1 (de) | 1998-01-21 | 2005-11-15 | Millennium Pharm Inc | Chemokin rezeptor antagonisten und verwndung |
| US6613905B1 (en) | 1998-01-21 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6509346B2 (en) | 1998-01-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US7271176B2 (en) | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
| US6503926B2 (en) | 1998-09-04 | 2003-01-07 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6288083B1 (en) | 1998-09-04 | 2001-09-11 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US7541365B2 (en) | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| TWI291467B (en) | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
| US5719148A (en) * | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| CA2240846C (fr) * | 1995-12-22 | 2002-07-16 | Schering Corporation | Amides tricycliques destines a l'inhibition de la fonction de la proteine-g et au traitement des maladies proliferatives |
-
1997
- 1997-09-11 ES ES97941478T patent/ES2163195T3/es not_active Expired - Lifetime
- 1997-09-11 AU AU43377/97A patent/AU4337797A/en not_active Abandoned
- 1997-09-11 ID IDW990087A patent/ID22156A/id unknown
- 1997-09-11 WO PCT/US1997/015905 patent/WO1998011099A1/fr not_active Application Discontinuation
- 1997-09-11 HU HU9904056A patent/HUP9904056A3/hu unknown
- 1997-09-11 CN CN97199527A patent/CN1122031C/zh not_active Expired - Fee Related
- 1997-09-11 JP JP10513763A patent/JP2001500508A/ja not_active Ceased
- 1997-09-11 KR KR1019997002125A patent/KR20000036103A/ko not_active Withdrawn
- 1997-09-11 EP EP97941478A patent/EP0931079B1/fr not_active Expired - Lifetime
- 1997-09-11 PL PL97332253A patent/PL332253A1/xx unknown
- 1997-09-11 AT AT97941478T patent/ATE209201T1/de not_active IP Right Cessation
- 1997-09-11 CZ CZ99874A patent/CZ87499A3/cs unknown
- 1997-09-11 IL IL12892997A patent/IL128929A0/xx unknown
- 1997-09-11 BR BR9711477A patent/BR9711477A/pt unknown
- 1997-09-11 NZ NZ334437A patent/NZ334437A/xx unknown
- 1997-09-11 TR TR1999/01205T patent/TR199901205T2/xx unknown
- 1997-09-11 DE DE69709774T patent/DE69709774T2/de not_active Expired - Fee Related
- 1997-09-11 CA CA002264513A patent/CA2264513C/fr not_active Expired - Fee Related
- 1997-09-11 SK SK335-99A patent/SK33599A3/sk unknown
-
1999
- 1999-03-12 NO NO991229A patent/NO991229L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20000036103A (ko) | 2000-06-26 |
| NO991229D0 (no) | 1999-03-12 |
| CA2264513C (fr) | 2004-03-30 |
| ES2163195T3 (es) | 2002-01-16 |
| CN1236364A (zh) | 1999-11-24 |
| DE69709774D1 (de) | 2002-02-21 |
| NO991229L (no) | 1999-05-12 |
| SK33599A3 (en) | 2000-03-13 |
| NZ334437A (en) | 2000-09-29 |
| PL332253A1 (en) | 1999-08-30 |
| ID22156A (id) | 1999-09-09 |
| EP0931079A1 (fr) | 1999-07-28 |
| BR9711477A (pt) | 1999-08-24 |
| CZ87499A3 (cs) | 1999-08-11 |
| HUP9904056A2 (hu) | 2000-04-28 |
| TR199901205T2 (xx) | 1999-07-21 |
| CN1122031C (zh) | 2003-09-24 |
| HK1018443A1 (en) | 1999-12-24 |
| WO1998011099A1 (fr) | 1998-03-19 |
| CA2264513A1 (fr) | 1998-03-19 |
| ATE209201T1 (de) | 2001-12-15 |
| EP0931079B1 (fr) | 2001-11-21 |
| DE69709774T2 (de) | 2002-08-08 |
| AU4337797A (en) | 1998-04-02 |
| HUP9904056A3 (en) | 2001-10-29 |
| JP2001500508A (ja) | 2001-01-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL128928A0 (en) | Tricyclic inhibitors of farnesyl protein transferase | |
| IL128929A0 (en) | Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase | |
| NO991235D0 (no) | Forbindelser anvendelige for inhibering av farnesylproteintransferase | |
| IL128927A0 (en) | Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase | |
| IL128930A0 (en) | Compounds useful for inhibition of farnesyl protein transferase |