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IL121440A0 - The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives - Google Patents

The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives

Info

Publication number
IL121440A0
IL121440A0 IL12144097A IL12144097A IL121440A0 IL 121440 A0 IL121440 A0 IL 121440A0 IL 12144097 A IL12144097 A IL 12144097A IL 12144097 A IL12144097 A IL 12144097A IL 121440 A0 IL121440 A0 IL 121440A0
Authority
IL
Israel
Prior art keywords
derivatives
helianthrone
tetrahydroxy
photodynamic therapy
certain
Prior art date
Application number
IL12144097A
Other languages
English (en)
Original Assignee
Yeda Res & Dev
Univ New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev, Univ New York filed Critical Yeda Res & Dev
Priority to IL12144097A priority Critical patent/IL121440A0/xx
Publication of IL121440A0 publication Critical patent/IL121440A0/xx
Priority to IL13424898A priority patent/IL134248A0/xx
Priority to AU83555/98A priority patent/AU8355598A/en
Priority to CA002298820A priority patent/CA2298820C/en
Priority to PCT/IL1998/000346 priority patent/WO1999006347A1/en
Priority to DE69813828T priority patent/DE69813828T2/de
Priority to AT98933874T priority patent/ATE238264T1/de
Priority to EP98933874A priority patent/EP1001924B1/en
Priority to US09/494,296 priority patent/US6229048B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/36—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/95—Esters of quinone carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/54—Ortho- or ortho- and peri-condensed systems containing more than five condensed rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL12144097A 1997-07-31 1997-07-31 The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives IL121440A0 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IL12144097A IL121440A0 (en) 1997-07-31 1997-07-31 The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives
IL13424898A IL134248A0 (en) 1997-07-31 1998-07-27 The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives
AU83555/98A AU8355598A (en) 1997-07-31 1998-07-27 The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in phot odynamictherapy and certain such novel derivatives
CA002298820A CA2298820C (en) 1997-07-31 1998-07-27 The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives
PCT/IL1998/000346 WO1999006347A1 (en) 1997-07-31 1998-07-27 The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives
DE69813828T DE69813828T2 (de) 1997-07-31 1998-07-27 Verwendung v0n 1,3,4,6-tetrahydroxy-helianthron und derivaten in der photodynamischen therapie und derivate
AT98933874T ATE238264T1 (de) 1997-07-31 1998-07-27 Verwendung v0n 1,3,4,6-tetrahydroxy-helianthron und derivaten in der photodynamischen therapie und derivate
EP98933874A EP1001924B1 (en) 1997-07-31 1998-07-27 The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives
US09/494,296 US6229048B1 (en) 1997-07-31 2000-01-31 Helianthrone derivatives as anti-cancer agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL12144097A IL121440A0 (en) 1997-07-31 1997-07-31 The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives

Publications (1)

Publication Number Publication Date
IL121440A0 true IL121440A0 (en) 1998-01-04

Family

ID=11070450

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12144097A IL121440A0 (en) 1997-07-31 1997-07-31 The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives

Country Status (8)

Country Link
US (1) US6229048B1 (xx)
EP (1) EP1001924B1 (xx)
AT (1) ATE238264T1 (xx)
AU (1) AU8355598A (xx)
CA (1) CA2298820C (xx)
DE (1) DE69813828T2 (xx)
IL (1) IL121440A0 (xx)
WO (1) WO1999006347A1 (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794518B1 (en) 1998-12-18 2004-09-21 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
WO2001056558A1 (en) 2000-01-31 2001-08-09 Yeda Research And Development Co. Ltd. Polycyclic dianthraquinones as anti-cancer and anti-angiogenic agents
CA2413957A1 (en) * 2000-06-21 2001-12-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals for use in combination therapy
EP1379274A4 (en) * 2001-03-23 2006-02-15 Univ Texas METHODS FOR INHIBITING ANGIOGENESIS, TUMOR GROWTH AND METASTASIS USING ANTI-HUMAN ANTI-IL8 AND ANTI-MUC18 IN VARIOUS TYPES OF TUMORS
US6838074B2 (en) 2001-08-08 2005-01-04 Bristol-Myers Squibb Company Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
ES2307824T3 (es) 2001-12-28 2008-12-01 Amgen Fremont Inc. Uso de anticuerpos contra el antigeno muc18.
JP2005516965A (ja) * 2001-12-28 2005-06-09 アブジェニックス・インコーポレーテッド 抗ｍｕｃ１８抗体を使用する方法
CA2659800A1 (en) * 2006-08-03 2008-02-07 Hy Biopharma Inc. Polycyclic dianthraquinones as inhibitors of inflammatory cytokines
EP2571507B1 (en) 2010-05-04 2017-01-04 Soligenix, Inc. Formulations and methods of treatment of skin conditions
EP3423428B1 (en) 2016-03-01 2024-07-24 Soligenix, Inc. Systems and methods for producing synthetic hypericin

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL79661A (en) 1986-08-08 1991-01-31 Yeda Res & Dev Antiviral composition containing hypericin or pseudohypericin
IL93682A (en) 1989-03-16 1996-06-18 Yeda Res & Dev Polycyclic compounds with antigypical activity are used in the manufacture of medicines and pharmaceutical preparations containing them
JP2735609B2 (ja) * 1989-03-31 1998-04-02 協和醗酵工業株式会社 Ｕｃｎ―１０２８ｄ誘導体
IL92315A (en) 1989-11-15 1996-12-05 Yeda Res & Dev Preparation of Hypericin from Amodin Enron
US5466468A (en) 1990-04-03 1995-11-14 Ciba-Geigy Corporation Parenterally administrable liposome formulation comprising synthetic lipids
US5514714A (en) 1990-08-23 1996-05-07 New York University Methods and polycyclic aromatic compound containing compositions for treating T-cell-mediated diseases
IL104693A0 (en) 1992-02-14 1993-06-10 Yeda Res & Dev Hypericin derivatives and pharmaceutical compositions comprising them
TW235298B (xx) 1992-02-27 1994-12-01 Ciba Geigy
EP0675955A1 (en) * 1992-12-23 1995-10-11 Iowa State University Research Foundation, Inc. Molecular flashlight
US6576784B1 (en) * 1993-05-27 2003-06-10 Yeda Research And Development Co. Ltd. Antiviral agents
US5824654A (en) * 1994-09-02 1998-10-20 New York University Method for delivery of nucleic acids to cells using hypericin polyamine complexes
US5556992A (en) 1994-09-02 1996-09-17 Universite De Montreal Novel rhodamine derivatives for photodynamic therapy of cancer and in vitro purging of the leukemias

Also Published As

Publication number Publication date
CA2298820C (en) 2008-06-03
CA2298820A1 (en) 1999-02-11
EP1001924B1 (en) 2003-04-23
DE69813828D1 (de) 2003-05-28
WO1999006347A1 (en) 1999-02-11
EP1001924A1 (en) 2000-05-24
DE69813828T2 (de) 2004-03-04
US6229048B1 (en) 2001-05-08
ATE238264T1 (de) 2003-05-15
AU8355598A (en) 1999-02-22

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