IL123950A - Substituted imidazoles having anti-cancer and cytokine inhibitory activity and pharmaceutical compositions containing them - Google Patents

Substituted imidazoles having anti-cancer and cytokine inhibitory activity and pharmaceutical compositions containing them

Info

Publication number: IL123950A
Authority: IL; Israel
Prior art keywords: alkyl; group; imidazol; cycloalkyl; pyridin
Prior art date: 1995-10-06

Application number

IL12395096A

Other languages

English (en)

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-06

Filing date

1996-10-02

Publication date

2001-04-30

1996-02-13 Priority claimed from GBGB9602975.6A external-priority patent/GB9602975D0/en

1996-02-13 Priority claimed from GBGB9602907.9A external-priority patent/GB9602907D0/en

1996-10-02 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2001-04-30 Publication of IL123950A publication Critical patent/IL123950A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Virology (AREA)
Hematology (AREA)
Diabetes (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

IL12395096A 1995-10-06 1996-10-02 Substituted imidazoles having anti-cancer and cytokine inhibitory activity and pharmaceutical compositions containing them IL123950A (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US506395P	1995-10-06	1995-10-06
US505995P	1995-10-06	1995-10-06
GBGB9602975.6A GB9602975D0 (en)	1996-02-13	1996-02-13	Acyl heterocylcic substituted imidazoles having anti-cancer and cytokine inhibitory activity
GBGB9602907.9A GB9602907D0 (en)	1996-02-13	1996-02-13	Substituted imidazoles having anti-cancer and cytokine inhibitory activity
PCT/US1996/015880 WO1997012876A1 (fr)	1995-10-06	1996-10-02	Imidazoles substitues ayant une activite anticancereuse et inhibitrice de cytokine

Publications (1)

Publication Number	Publication Date
IL123950A true IL123950A (en)	2001-04-30

Family

ID=27451400

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12395096A IL123950A (en)	1995-10-06	1996-10-02	Substituted imidazoles having anti-cancer and cytokine inhibitory activity and pharmaceutical compositions containing them

Country Status (17)

Country	Link
EP (1)	EP0854870B1 (fr)
JP (1)	JP3382951B2 (fr)
KR (1)	KR19990064117A (fr)
CN (1)	CN1117082C (fr)
AT (1)	ATE433446T1 (fr)
AU (1)	AU702146B2 (fr)
CA (1)	CA2234066C (fr)
CZ (1)	CZ292707B6 (fr)
DE (1)	DE69637948D1 (fr)
EA (1)	EA001203B1 (fr)
EE (1)	EE03681B1 (fr)
IL (1)	IL123950A (fr)
NO (1)	NO981528L (fr)
NZ (1)	NZ321738A (fr)
PL (1)	PL184819B1 (fr)
SK (1)	SK282496B6 (fr)
WO (1)	WO1997012876A1 (fr)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5916891A (en)	1992-01-13	1999-06-29	Smithkline Beecham Corporation	Pyrimidinyl imidazoles
US6046208A (en) *	1996-01-11	2000-04-04	Smithkline Beecham Corporation	Substituted imidazole compounds
JP2000504023A (ja) *	1996-04-03	2000-04-04	メルクエンドカンパニーインコーポレーテッド	癌治療方法
US6096753A (en)	1996-12-05	2000-08-01	Amgen Inc.	Substituted pyrimidinone and pyridone compounds and methods of use
EP1314731A3 (fr) *	1996-12-05	2004-01-02	Amgen Inc.	Composés de pyrimidine substitués et leur utilisation
BR9713863A (pt) *	1996-12-05	2000-03-14	Amgen Inc	Composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, processos de profilaxia ou tratamento, para abaixar as concentrações no plasma, para diminuir a produção de prostaglandinas, e, para diminuir a atividade de enzima ciclooxigenase
US6410729B1 (en)	1996-12-05	2002-06-25	Amgen Inc.	Substituted pyrimidine compounds and methods of use
AR038955A1 (es) *	1996-12-05	2005-02-02	Amgen Inc	Compuestos de pirimidinona y piridona sustituidos y metodos para su uso
US6147080A (en) *	1996-12-18	2000-11-14	Vertex Pharmaceuticals Incorporated	Inhibitors of p38
US5945418A (en) *	1996-12-18	1999-08-31	Vertex Pharmaceuticals Incorporated	Inhibitors of p38
US6608060B1 (en)	1996-12-18	2003-08-19	Vertex Pharmaceuticals Incorporated	Inhibitors of p38
DE69835518T2 (de)	1997-06-12	2007-08-09	Aventis Pharma Ltd., West Malling	Imidazolyl-cyclische acetale
EP1023066A4 (fr)	1997-06-13	2001-05-23	Smithkline Beecham Corp	Nouveaux composes de pyrazole et de pyrazoline substitues
JP2002505690A (ja)	1997-06-19	2002-02-19	スミスクライン・ビーチャム・コーポレイション	新規なアリールオキシピリミジン置換イミダゾール化合物
GB9713726D0 (en) *	1997-06-30	1997-09-03	Ciba Geigy Ag	Organic compounds
US6562832B1 (en)	1997-07-02	2003-05-13	Smithkline Beecham Corporation	Substituted imidazole compounds
US7301021B2 (en)	1997-07-02	2007-11-27	Smithkline Beecham Corporation	Substituted imidazole compounds
EP1019396A1 (fr)	1997-07-02	2000-07-19	SmithKline Beecham Corporation	Nouveaux imidazoles cycloalkyle-substitues
WO1999017776A1 (fr)	1997-10-08	1999-04-15	Smithkline Beecham Corporation	Nouveaux composes substitues de cycloalcenyle
CA2314980A1 (fr)	1997-12-19	1999-07-01	Smithkline Beecham Corporation	.0mposes d'imidazole heteroaryle substitues, leurs compositions et usages pharmaceutiques
BR9910621A (pt)	1998-05-22	2001-01-30	Smithkline Beecham Corp	Novos compostos de imidazol 2-alquil substituìdos
US6858617B2 (en)	1998-05-26	2005-02-22	Smithkline Beecham Corporation	Substituted imidazole compounds
JP2002526388A (ja)	1998-10-07	2002-08-20	スミスクライン・ビーチャム・コーポレイション	発作を管理するための新規な処置
EP1126852B1 (fr)	1998-11-04	2004-01-21	SmithKline Beecham Corporation	Pyrazines substitues pyridin-4-yle ou pyrimidin-4-yle
PL351148A1 (en)	1999-04-23	2003-03-24	Takeda Chemical Industries Ltd	5-pyridyl-1,3-azole compounds, process for producing the same and use thereof
US7122666B2 (en)	1999-07-21	2006-10-17	Sankyo Company, Limited	Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses
US6962933B1 (en)	1999-08-06	2005-11-08	Takeda Pharmaceutical Company Limited	Method for inhibiting p38 MAP kinase or TNF-α production using a 1,3-thiazole
EP1233950B1 (fr)	1999-11-23	2005-10-05	Smithkline Beecham Corporation	3,4-dihydro-(1h)quinazolin-2-ones comme inhibiteurs de csbp/p38 kinase
US7053098B1 (en)	1999-11-23	2006-05-30	Smithkline Beecham Corporation	3,4-Dihydro-(1H) quinazolin-2-one compounds as CSBP/P38 kinase inhibitors
US6759410B1 (en)	1999-11-23	2004-07-06	Smithline Beecham Corporation	3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
US7235551B2 (en)	2000-03-02	2007-06-26	Smithkline Beecham Corporation	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
GB0005357D0 (en)	2000-03-06	2000-04-26	Smithkline Beecham Plc	Compounds
US7235658B2 (en)	2000-03-06	2007-06-26	Smithkline Beecham P.L.C.	Imidazol derivatives as Raf kinase inhibitors
EP1268474A2 (fr)	2000-03-30	2003-01-02	Takeda Chemical Industries, Ltd.	Composes de 1,3-thiazole substitues, production et utilisation desdits composes
US6638950B2 (en)	2000-06-21	2003-10-28	Bristol-Myers Squibb Pharma Company	Piperidine amides as modulators of chemokine receptor activity
FR2818978B1 (fr) *	2000-12-28	2003-02-28	Sod Conseils Rech Applic	Modulateurs de canaux sodiques derives de 2-piperidylimidazoles
GB0112348D0 (en) *	2001-05-19	2001-07-11	Smithkline Beecham Plc	Compounds
CA2492033A1 (fr)	2002-07-09	2004-01-15	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Nouvelles compositions pharmaceutiques a base de nouveaux anticholinergiques et d'inhibiteurs de la kinase p38
US7135575B2 (en)	2003-03-03	2006-11-14	Array Biopharma, Inc.	P38 inhibitors and methods of use thereof
RU2357957C2 (ru)	2003-03-03	2009-06-10	Эррэй Биофарма, Инк.	Ингибиторы р38 и способы их применения
US7250434B2 (en)	2003-12-22	2007-07-31	Janssen Pharmaceutica N.V.	CCK-1 receptor modulators
US20060035893A1 (en)	2004-08-07	2006-02-16	Boehringer Ingelheim International Gmbh	Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
PE20060777A1 (es)	2004-12-24	2006-10-06	Boehringer Ingelheim Int	Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
RU2442777C2 (ru)	2006-01-31	2012-02-20	Эррэй Биофарма Инк.	Ингибиторы киназ и способы их применения
EP1992344A1 (fr)	2007-05-18	2008-11-19	Institut Curie	P38 alpha comme cible therapeutique pour les maladies associées á une mutation de FGFR3
BRPI0908906A2 (pt) *	2008-03-21	2019-09-24	Novartis Ag	compostos heterocíclicos e usos dos mesmos
WO2022186512A1 (fr) *	2021-03-04	2022-09-09	한양대학교 에리카산학협력단	Dérivé de pyridinyl pyrazole ou sel pharmaceutiquement acceptable de celui-ci, et son utilisation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX9300141A (es) *	1992-01-13	1994-07-29	Smithkline Beecham Corp	Compuestos de imidazol novedosos, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
ZA945363B (en) *	1993-07-21	1995-03-14	Smithkline Beecham Corp	Novel compounds

1996
- 1996-10-02 AT AT96937654T patent/ATE433446T1/de not_active IP Right Cessation
- 1996-10-02 EP EP96937654A patent/EP0854870B1/fr not_active Expired - Lifetime
- 1996-10-02 AU AU75143/96A patent/AU702146B2/en not_active Ceased
- 1996-10-02 EE EE9800083A patent/EE03681B1/xx not_active IP Right Cessation
- 1996-10-02 JP JP51442897A patent/JP3382951B2/ja not_active Expired - Fee Related
- 1996-10-02 NZ NZ321738A patent/NZ321738A/xx unknown
- 1996-10-02 CN CN96198718A patent/CN1117082C/zh not_active Expired - Fee Related
- 1996-10-02 PL PL96326025A patent/PL184819B1/pl unknown
- 1996-10-02 SK SK435-98A patent/SK282496B6/sk unknown
- 1996-10-02 IL IL12395096A patent/IL123950A/en not_active IP Right Cessation
- 1996-10-02 CA CA002234066A patent/CA2234066C/fr not_active Expired - Fee Related
- 1996-10-02 CZ CZ19981043A patent/CZ292707B6/cs not_active IP Right Cessation
- 1996-10-02 DE DE69637948T patent/DE69637948D1/de not_active Expired - Fee Related
- 1996-10-02 EA EA199800268A patent/EA001203B1/ru not_active IP Right Cessation
- 1996-10-02 WO PCT/US1996/015880 patent/WO1997012876A1/fr not_active Application Discontinuation
- 1996-10-02 KR KR1019980702598A patent/KR19990064117A/ko not_active Ceased
1998
- 1998-04-03 NO NO981528A patent/NO981528L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU702146B2 (en)	1999-02-11
SK43598A3 (en)	1998-11-04
JP3382951B2 (ja)	2003-03-04
CA2234066C (fr)	2005-12-13
EE03681B1 (et)	2002-04-15
WO1997012876A1 (fr)	1997-04-10
JPH11514353A (ja)	1999-12-07
NO981528L (no)	1998-06-05
EA001203B1 (ru)	2000-12-25
DE69637948D1 (de)	2009-07-23
EE9800083A (et)	1998-10-15
KR19990064117A (ko)	1999-07-26
ATE433446T1 (de)	2009-06-15
CZ292707B6 (cs)	2003-11-12
AU7514396A (en)	1997-04-28
SK282496B6 (sk)	2002-02-05
PL184819B1 (pl)	2002-12-31
EA199800268A1 (ru)	1998-12-24
EP0854870B1 (fr)	2009-06-10
CA2234066A1 (fr)	1997-04-10
CN1203590A (zh)	1998-12-30
EP0854870A4 (fr)	1999-01-07
CZ104398A3 (cs)	1998-07-15
NZ321738A (en)	1999-11-29
PL326025A1 (en)	1998-08-17
EP0854870A1 (fr)	1998-07-29
NO981528D0 (no)	1998-04-03
CN1117082C (zh)	2003-08-06

Publication	Publication Date	Title
AU702146B2 (en)	1999-02-11	Substituted imidazoles having anti-cancer and cytokine inhibitory activity
US5717100A (en)	1998-02-10	Substituted imidazoles having anti-cancer and cytokine inhibitory activity
WO1997012876A9 (fr)	1997-09-18	Imidazoles substitues ayant une activite anticancereuse et inhibitrice de cytokine
EP1109803B1 (fr)	2007-01-10	Imidazoles substitues a activite inhibitrice de la cytokine
EP0906307B1 (fr)	2005-04-27	Imidazoles substitues inhibant la cytokine
US6602872B1 (en)	2003-08-05	Substituted pyridazines having cytokine inhibitory activity
US6350744B1 (en)	2002-02-26	Compounds having cytokine inhibitory activity
US6083949A (en)	2000-07-04	Substituted imidazoles having anti-cancer and cytokine inhibitory activity
US6291457B1 (en)	2001-09-18	Compounds having cytokine inhibitory activity
HUP9902294A2 (hu)	2000-04-28	Rákellenes és citokingátló hatású szubsztituált imidazolszármazékok, továbbá ezeket tartalmazó gyógyászati készítmények
CA2257200C (fr)	2006-05-23	Imidazoles substitues inhibant la cytokine
WO2001022965A1 (fr)	2001-04-05	Imizadoles substitues a activite inhibitrice de la cytokine
MXPA98002732A (en)	1998-11-16	Substitute imidazolas that have anticancer activity and citoc inhibitor

Legal Events

Date	Code	Title	Description
2003-01-12	KB	Patent renewed
2007-07-24	MM9K	Patent not in force due to non-payment of renewal fees