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IL137531A0 - Mutant herpes simplex viruses and uses thereof - Google Patents

Mutant herpes simplex viruses and uses thereof

Info

Publication number
IL137531A0
IL137531A0 IL13753199A IL13753199A IL137531A0 IL 137531 A0 IL137531 A0 IL 137531A0 IL 13753199 A IL13753199 A IL 13753199A IL 13753199 A IL13753199 A IL 13753199A IL 137531 A0 IL137531 A0 IL 137531A0
Authority
IL
Israel
Prior art keywords
herpes simplex
simplex viruses
mutant herpes
mutant
viruses
Prior art date
Application number
IL13753199A
Other languages
English (en)
Original Assignee
Biovex Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biovex Ltd filed Critical Biovex Ltd
Publication of IL137531A0 publication Critical patent/IL137531A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL13753199A 1998-01-29 1999-01-29 Mutant herpes simplex viruses and uses thereof IL137531A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9801930.0A GB9801930D0 (en) 1998-01-29 1998-01-29 Mutant herpes simplex viruses and uses thereof
PCT/GB1999/000306 WO1999038955A2 (fr) 1998-01-29 1999-01-29 Souches mutantes du virus de l'herpes et utilisations correspondantes

Publications (1)

Publication Number Publication Date
IL137531A0 true IL137531A0 (en) 2001-07-24

Family

ID=10826120

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13753199A IL137531A0 (en) 1998-01-29 1999-01-29 Mutant herpes simplex viruses and uses thereof

Country Status (11)

Country Link
US (1) US6719982B1 (fr)
EP (1) EP1049769A2 (fr)
JP (1) JP2002501742A (fr)
KR (1) KR20010040430A (fr)
CN (1) CN1295612A (fr)
AU (1) AU749017B2 (fr)
BR (1) BR9907283A (fr)
CA (1) CA2319669A1 (fr)
GB (2) GB9801930D0 (fr)
IL (1) IL137531A0 (fr)
WO (1) WO1999038955A2 (fr)

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GB9801930D0 (en) 1998-01-29 1998-03-25 Univ London Mutant herpes simplex viruses and uses thereof
GB0009079D0 (en) * 2000-04-12 2000-05-31 Neurovex Ltd Herpes viruses for immune modulation
GB9930419D0 (en) * 1999-12-22 2000-02-16 Neurovex Ltd Replication incompetent herpes virus vectors
GB9930418D0 (en) 1999-12-22 2000-02-16 Neurovex Ltd Replication incompetent herpes virus vectors
DE60107203T3 (de) 2000-01-21 2009-07-23 Biovex Ltd. Herpes-virusstämme für die gentherapie
US20050267061A1 (en) * 2004-04-08 2005-12-01 Sangamo Biosciences, Inc. Methods and compositions for treating neuropathic and neurodegenerative conditions
US20040229362A1 (en) * 2003-05-15 2004-11-18 Alberto Epstein Method for producing non-pathogenic helper virus-free preparations of herpes virus amplicon vectors, the helper virus & the cells used in this method, the corresponding genetic tools, as well as the applications of these non-pathogenic amplicon vectors
GB0317511D0 (en) * 2003-07-25 2003-08-27 Biovex Ltd Viral vectors
US7897146B2 (en) 2003-11-17 2011-03-01 Crusade Laboratories Limited Treatment using herpes simplex virus
GB0326798D0 (en) * 2003-11-17 2003-12-24 Crusade Lab Ltd Methods for generating mutant virus
EP1694852B1 (fr) 2003-11-17 2010-10-13 Crusade Laboratories Limited Virus mutant de l'herpes simplex et son utilisation pour traiter le carcinome spinocellulaire
GB0408103D0 (en) * 2004-04-08 2004-05-12 Crusade Lab Ltd Novel herpes simplex viruses
US20060023160A1 (en) * 2004-08-02 2006-02-02 Cartier Jon P Lens structure and method of making the same
US20100008944A1 (en) * 2005-07-29 2010-01-14 President And Fellows Of Harvard College Herpes simplex virus mutant and uses therefore
KR102649583B1 (ko) * 2013-07-17 2024-03-20 유니버시티 오브 피츠버그-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 효율적인 유전자 전달 적용을 위한 비독성 hsv 벡터 및 이의 생산을 위한 보완 세포
CN105219738A (zh) * 2015-09-21 2016-01-06 北京神源德生物科技有限公司 重组单纯疱疹病毒及它感染和制备它的宿主细胞以及它们的应用
CN105219739A (zh) * 2015-09-21 2016-01-06 北京神源德生物科技有限公司 重组单纯疱疹病毒及它感染和制备它的宿主细胞以及它们的应用
ES2796488T3 (es) * 2016-04-08 2020-11-27 Krystal Biotech Inc Composiciones para el uso en métodos para el tratamiento de heridas, trastornos y enfermedades de la piel
KR20250024105A (ko) 2016-04-15 2025-02-18 알파인 이뮨 사이언시즈, 인코포레이티드 Cd80 변이체 면역조절 단백질 및 그의 용도
EP3442999A2 (fr) 2016-04-15 2019-02-20 Alpine Immune Sciences, Inc. Protéines immunomodulatrices à variants du ligand icos et leurs utilisations
RU2751236C2 (ru) 2016-04-22 2021-07-12 Иммвира Ко., Лимитед КОНСТРУИРОВАНИЕ ОБЛИГАТНОГО ВЕКТОРА НА ОСНОВЕ ОНКОЛИТИЧЕСКИХ ВИРУСОВ ПРОСТОГО ГЕРПЕСА (oHSV) И КОНСТРУКЦИИ ДЛЯ ТЕРАПИИ РАКА
US11471488B2 (en) 2016-07-28 2022-10-18 Alpine Immune Sciences, Inc. CD155 variant immunomodulatory proteins and uses thereof
WO2018022946A1 (fr) 2016-07-28 2018-02-01 Alpine Immune Sciences, Inc. Protéines immunomodulatrices à variants de cd155 et leurs utilisations
US11834490B2 (en) 2016-07-28 2023-12-05 Alpine Immune Sciences, Inc. CD112 variant immunomodulatory proteins and uses thereof
WO2018023114A1 (fr) * 2016-07-29 2018-02-01 Ohio State Innovation Foundation Expression de pten-long avec des virus ocolytiques
CN106318915B (zh) * 2016-09-21 2020-02-18 重庆宇珩生物科技有限公司 重组单纯疱疹病毒HSV-hTERTp_ICP4_LungCA-GFP及诊断试剂盒
US20200040059A1 (en) 2016-10-20 2020-02-06 Alpine Immune Sciences, Inc. Secretable variant immunomodulatory proteins and engineered cell therapy
CA3052473A1 (fr) 2017-02-09 2018-08-16 Indapta Therapeutics, Inc. Cellules tueuses naturelles (nk) modifiees et compositions et procedes associes
IL268781B2 (en) 2017-03-16 2025-09-01 Alpine Immune Sciences Inc CD80 Variant Immune Modulator Proteins and Uses Thereof
EP3596115A1 (fr) 2017-03-16 2020-01-22 Alpine Immune Sciences, Inc. Protéines immunomodulatrices à variants pd-l2 et utilisations associées
KR20240123406A (ko) 2017-03-16 2024-08-13 알파인 이뮨 사이언시즈, 인코포레이티드 Pd-l1 리간드 변이체 면역조절 단백질 및 그의 용도
JP7749319B2 (ja) 2017-10-10 2025-10-06 アルパイン イミューン サイエンシズ インコーポレイテッド Ｃｔｌａ－４変異型免疫調節タンパク質およびそれらの使用
KR20250034197A (ko) 2017-10-18 2025-03-10 알파인 이뮨 사이언시즈, 인코포레이티드 변이체 icos 리간드 면역조절 단백질 및 관련 조성물 및 방법
BR112020013236A2 (pt) 2018-01-03 2020-12-01 Alpine Immune Sciences, Inc. proteínas imunomoduladoras de múltiplos domínios e métodos de seu uso
EP3775236A1 (fr) 2018-04-12 2021-02-17 Krystal Biotech, LLC Compositions et procédés pour le traitement d'une ichtyose congénitale autosomique récessive
CN119523872A (zh) 2018-04-27 2025-02-28 克里斯托生物技术股份有限公司 用于美容性应用的编码一种或多种美容蛋白的重组核酸
US12065476B2 (en) 2018-06-15 2024-08-20 Alpine Immune Sciences, Inc. PD-1 variant immunomodulatory proteins and uses thereof
US20200093874A1 (en) 2018-09-24 2020-03-26 Krystal Biotech, Inc. Compositions and methods for the treatment of netherton syndrome
JP7541516B2 (ja) 2018-11-21 2024-08-28 インダプタ セラピューティクス インコーポレイテッド ナチュラルキラー（ｎｋ）細胞サブセットの増大のための方法ならびに関連する組成物および方法
JP7713886B2 (ja) 2018-11-30 2025-07-28 アルパイン イミューン サイエンシズ インコーポレイテッド Ｃｄ８６バリアント免疫調節タンパク質およびその使用
KR20210124277A (ko) 2019-02-08 2021-10-14 크리스탈 바이오테크, 인크. Cftr 폴리펩타이드를 전달하기 위한 조성물 및 방법
US20230190801A1 (en) 2020-04-22 2023-06-22 Indapta Therapeutics, Inc. Natural killer (nk) cell compositions and methods for generating same
AU2021267276B2 (en) 2020-05-08 2024-10-24 Alpine Immune Sciences, Inc. APRIL and BAFF inhibitory immunomodulatory proteins and methods of use thereof
WO2022170219A1 (fr) 2021-02-05 2022-08-11 Iovance Biotherapeutics, Inc. Traitement adjuvant du cancer
EP4314028A1 (fr) 2021-04-02 2024-02-07 Krystal Biotech, Inc. Vecteurs viraux pour la thérapie du cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5665362A (en) * 1990-09-25 1997-09-09 Cantab Pharmaceuticals Research Limited Viral vaccines
US6010908A (en) * 1992-08-21 2000-01-04 The Regents Of The University Of California Gene therapy by small fragment homologous replacement
US5658724A (en) * 1992-07-31 1997-08-19 University Of Pittsburgh Of The Commonwealth System Of Higher Education Herpes simplex virus strains deficient for the essential immediate early genes ICP4 and ICP27 and methods for their production, growth and use
WO1997010349A1 (fr) 1995-09-11 1997-03-20 Arch Development Corporation Matieres et procedes de traitement de maladies neurodegeneratives et de recherche systematique d'inhibiteurs et d'inducteurs potentiels de l'apoptose
GB9615794D0 (en) * 1996-07-26 1996-09-04 Medical Res Council Mutant herpes simplex virus strains and uses thereof
GB9700411D0 (en) 1997-01-10 1997-02-26 Univ London Eukaryotic gene expression cassette and uses thereof
GB9801930D0 (en) 1998-01-29 1998-03-25 Univ London Mutant herpes simplex viruses and uses thereof

Also Published As

Publication number Publication date
KR20010040430A (ko) 2001-05-15
GB9801930D0 (en) 1998-03-25
JP2002501742A (ja) 2002-01-22
WO1999038955A3 (fr) 1999-09-23
GB2353529A (en) 2001-02-28
GB0020940D0 (en) 2000-10-11
WO1999038955A2 (fr) 1999-08-05
EP1049769A2 (fr) 2000-11-08
CN1295612A (zh) 2001-05-16
CA2319669A1 (fr) 1999-08-05
AU2291199A (en) 1999-08-16
BR9907283A (pt) 2000-10-24
GB2353529B (en) 2003-01-15
HK1035378A1 (en) 2001-11-23
US6719982B1 (en) 2004-04-13
AU749017B2 (en) 2002-06-13

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