IL145772A0 - Prodrugs of thrombin inhibitors - Google Patents

Prodrugs of thrombin inhibitors

Info

Publication number: IL145772A0
Authority: IL; Israel
Prior art keywords: prodrugs; thrombin inhibitors; thrombin; inhibitors
Prior art date: 1999-04-09

Application number

IL14577200A

Other languages

English (en)

Original Assignee

Basf Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-09

Filing date

2000-04-05

Publication date

2002-07-25

2000-04-05 Application filed by Basf Ag filed Critical Basf Ag

2002-07-25 Publication of IL145772A0 publication Critical patent/IL145772A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)

IL14577200A 1999-04-09 2000-04-05 Prodrugs of thrombin inhibitors IL145772A0 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DE19915930		1999-04-09
DE19934123		1999-07-23
DE19947920		1999-10-06
PCT/EP2000/003009 WO2000061609A2 (fr)	1999-04-09	2000-04-05	Promedicaments d'inhibiteurs de la thrombine

Publications (1)

Publication Number	Publication Date
IL145772A0 true IL145772A0 (en)	2002-07-25

Family

ID=27219075

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL14577200A IL145772A0 (en)	1999-04-09	2000-04-05	Prodrugs of thrombin inhibitors

Country Status (18)

Country	Link
US (1)	US7144902B1 (fr)
EP (1)	EP1165601A2 (fr)
JP (1)	JP2002542165A (fr)
KR (1)	KR20010108481A (fr)
CN (1)	CN1355810A (fr)
AU (1)	AU765244B2 (fr)
BG (1)	BG105986A (fr)
BR (1)	BR0009674A (fr)
CA (1)	CA2370267A1 (fr)
HK (1)	HK1046289A1 (fr)
HU (1)	HUP0202401A3 (fr)
IL (1)	IL145772A0 (fr)
NO (1)	NO20014875L (fr)
NZ (1)	NZ515026A (fr)
PL (1)	PL352824A1 (fr)
SK (1)	SK14222001A3 (fr)
TR (1)	TR200102912T2 (fr)
WO (1)	WO2000061609A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10064797A1 (de) *	2000-12-22	2002-06-27	Knoll Ag	Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon
WO2004002985A1 (fr) *	2002-06-27	2004-01-08	Lg Life Sciences Ltd.	Compose peptidique inhibiteur de la thrombine
KR101154246B1 (ko)	2003-05-16	2012-06-13	내셔날 인스티튜트 포 바이올로지칼 스탠다즈 앤 컨트롤 (엔아이비에스씨)	활성화 혼합물
US7939629B2 (en)	2004-10-19	2011-05-10	Lonza Ag	Method for solid phase peptide synthesis
CA2607020C (fr) *	2005-05-05	2015-01-13	Chroma Therapeutics Ltd.	Conjugues d'ester amine alpha hydrolysables par des coarboxylesterases
SG195607A1 (en)	2005-05-10	2013-12-30	Incyte Corp	Modulators of indoleamine 2,3-dioxygenase and methods of using the same
JP5294874B2 (ja)	2005-12-20	2013-09-18	インサイト・コーポレイション	インドールアミン２，３−ジオキシゲナーゼのモジュレーターとしてのｎ−ヒドロキシアミジノヘテロ環
CA2663057C (fr) *	2006-09-19	2015-12-08	Incyte Corporation	N-hydroxyamidinoheterocycles en tant que modulateurs d'indoleamine 2,3-dioxygenase
CL2007002650A1 (es)	2006-09-19	2008-02-08	Incyte Corp	Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
EP3360873A1 (fr)	2008-07-08	2018-08-15	Incyte Holdings Corporation	1,2,5-oxadiazoles constituant des inhibiteurs de l'indoléamine 2,3-dioxygénase
JP2013515000A (ja)	2009-12-18	2013-05-02	アクティベサイトファーマシューティカルズインコーポレイティッド	血漿カリクレインの阻害薬のプロドラッグ
US9206123B2 (en)	2009-12-18	2015-12-08	Activesite Pharmaceuticals, Inc.	Prodrugs of inhibitors of plasma kallikrein
WO2012142308A1 (fr)	2011-04-13	2012-10-18	Activesite Pharmaceuticals, Inc.	Promédicaments d'inhibiteurs de la kallicréine plasmatique
TWI696618B (zh)	2013-11-08	2020-06-21	美商英塞特控股公司	用於合成吲哚胺2,3-雙加氧酶抑制劑之方法
JP6556146B2 (ja) *	2014-08-26	2019-08-07	武田薬品工業株式会社	複素環化合物
CN106674190B (zh) *	2016-12-13	2019-05-10	台州市创源工业技术有限公司	一种2-噻吩甲胺的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA951617B (en) *	1994-03-04	1997-02-27	Lilly Co Eli	Antithrombotic agents.
TW541316B (en)	1995-12-21	2003-07-11	Astrazeneca Ab	Prodrugs of thrombin inhibitors
TW523513B (en)	1996-03-01	2003-03-11	Akzo Nobel Nv	Serine protease inhibitors
DE19632773A1 (de)	1996-08-14	1998-02-19	Basf Ag	Neue Thrombininhibitoren
CN1289341A (zh) *	1998-01-26	2001-03-28	Basf公司	凝血酶抑制剂
EP1049673A1 (fr)	1998-01-26	2000-11-08	Basf Aktiengesellschaft	Amidines heterocycliques utilisees comme inhibiteurs de la kallicreine
KR20000047461A (ko) *	1998-12-29	2000-07-25	성재갑	트롬빈 억제제
HUP0203167A3 (en) *	1999-04-09	2003-09-29	Basf Ag	Peptidic substances, their preparations and their use as complement protease inhibitors

2000
- 2000-04-05 BR BR0009674-1A patent/BR0009674A/pt not_active IP Right Cessation
- 2000-04-05 WO PCT/EP2000/003009 patent/WO2000061609A2/fr not_active Application Discontinuation
- 2000-04-05 US US09/958,349 patent/US7144902B1/en not_active Expired - Fee Related
- 2000-04-05 TR TR2001/02912T patent/TR200102912T2/xx unknown
- 2000-04-05 SK SK1422-2001A patent/SK14222001A3/sk not_active Application Discontinuation
- 2000-04-05 JP JP2000611551A patent/JP2002542165A/ja active Pending
- 2000-04-05 CN CN00807958A patent/CN1355810A/zh active Pending
- 2000-04-05 HK HK02107849.6A patent/HK1046289A1/zh unknown
- 2000-04-05 PL PL00352824A patent/PL352824A1/xx unknown
- 2000-04-05 IL IL14577200A patent/IL145772A0/xx unknown
- 2000-04-05 CA CA002370267A patent/CA2370267A1/fr not_active Abandoned
- 2000-04-05 KR KR1020017012870A patent/KR20010108481A/ko not_active Ceased
- 2000-04-05 AU AU41156/00A patent/AU765244B2/en not_active Ceased
- 2000-04-05 HU HU0202401A patent/HUP0202401A3/hu unknown
- 2000-04-05 NZ NZ515026A patent/NZ515026A/en unknown
- 2000-04-05 EP EP00920661A patent/EP1165601A2/fr not_active Withdrawn
2001
- 2001-10-05 BG BG105986A patent/BG105986A/bg unknown
- 2001-10-08 NO NO20014875A patent/NO20014875L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
WO2000061609B1 (fr)	2001-04-26
NO20014875D0 (no)	2001-10-08
TR200102912T2 (tr)	2002-03-21
WO2000061609A2 (fr)	2000-10-19
AU765244B2 (en)	2003-09-11
PL352824A1 (en)	2003-09-08
AU4115600A (en)	2000-11-14
WO2000061609A3 (fr)	2001-03-15
KR20010108481A (ko)	2001-12-07
NO20014875L (no)	2001-11-13
CN1355810A (zh)	2002-06-26
BR0009674A (pt)	2002-01-15
US7144902B1 (en)	2006-12-05
HUP0202401A2 (en)	2002-10-28
CA2370267A1 (fr)	2000-10-19
SK14222001A3 (sk)	2002-07-02
HUP0202401A3 (en)	2003-11-28
HK1046289A1 (zh)	2003-01-03
NZ515026A (en)	2003-10-31
JP2002542165A (ja)	2002-12-10
BG105986A (bg)	2002-06-28
EP1165601A2 (fr)	2002-01-02

Publication	Publication Date	Title
GB9912961D0 (en)	1999-08-04	Metalloprotease inhibitors
IL149118A0 (en)	2002-11-10	Inhibitors of neuraminidases
EP1124822A4 (fr)	2002-04-03	Inhibiteurs de la thrombine
GB9900416D0 (en)	1999-02-24	Inhibitors
GB9930659D0 (en)	2000-02-16	Inhibitors of complement activation
IL145772A0 (en)	2002-07-25	Prodrugs of thrombin inhibitors
IL145085A0 (en)	2002-06-30	Dihetero-substituted metalloprotease inhibitors
EP1117660A4 (fr)	2002-01-09	Inhibiteurs de la thrombine
IL136139A0 (en)	2001-05-20	Thrombin inhibitors
EP1235577A4 (fr)	2003-04-09	Inhibiteurs de protease
EP1153022A4 (fr)	2002-03-27	Inhibiteurs de protease
GB0030284D0 (en)	2001-01-24	Enzyme inhibitors
GB9924522D0 (en)	1999-12-15	Enzyme inhibitors
EP1232155A4 (fr)	2002-11-20	Inhibiteurs de protease
EP1231921A4 (fr)	2004-06-23	Inhibiteurs de proteases
EP1229912A4 (fr)	2003-05-07	Inhibiteurs de protease
EP1229914A4 (fr)	2004-06-23	Inhibiteurs de protease
EP1229915A4 (fr)	2003-05-14	Inhibiteurs de protease
EP1233771A4 (fr)	2003-05-14	Inhibiteurs de protease
EP1351930A4 (fr)	2004-09-15	Inhibiteurs de la protease
EP1161237A4 (fr)	2002-03-27	Inhibiteurs de protease
EP1229911A4 (fr)	2003-05-07	Inhibiteurs de proteases
EP1173429A4 (fr)	2002-06-19	Inhibiteurs de protease
EP1231923A4 (fr)	2003-05-14	Inhibiteurs de protease
IL145670A0 (en)	2002-06-30	Prodrugs of thrombin inhibitors

Legal Events

Date	Code	Title	Description
2003-05-29	HP	Change in proprietorship