IL156827A0 - Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators - Google Patents

Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators

Info

Publication number: IL156827A0
Authority: IL; Israel
Prior art keywords: malonyl; azoles; coa decarboxylase; compounds; inhibitors useful
Prior art date: 2001-02-20

Application number

IL15682702A

Other languages

English (en)

Original Assignee

Chugai Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-20

Filing date

2002-02-19

Publication date

2004-02-08

2002-02-19 Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd

2004-02-08 Publication of IL156827A0 publication Critical patent/IL156827A0/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IL15682702A 2001-02-20 2002-02-19 Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators IL156827A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US27003401P	2001-02-20	2001-02-20
PCT/US2002/004777 WO2002066035A2 (en)	2001-02-20	2002-02-19	Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators

Publications (1)

Publication Number	Publication Date
IL156827A0 true IL156827A0 (en)	2004-02-08

Family

ID=23029607

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL15682702A IL156827A0 (en)	2001-02-20	2002-02-19	Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators
IL156827A IL156827A (en)	2001-02-20	2003-07-08	Derivatives of 2-mercapto- [3,1] thiazolo [4,5 [b- pyridine and pharmaceutical preparations containing them for the treatment of cardiovascular disease

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL156827A IL156827A (en)	2001-02-20	2003-07-08	Derivatives of 2-mercapto- [3,1] thiazolo [4,5 [b- pyridine and pharmaceutical preparations containing them for the treatment of cardiovascular disease

Country Status (23)

Country	Link
US (1)	US7723366B2 (xx)
EP (2)	EP1370260B1 (xx)
JP (4)	JP4155351B2 (xx)
KR (1)	KR100659427B1 (xx)
CN (1)	CN100383132C (xx)
AT (2)	ATE489089T1 (xx)
AU (1)	AU2002251987B2 (xx)
BR (1)	BR0207408A (xx)
CA (1)	CA2437409C (xx)
CY (1)	CY1110986T1 (xx)
DE (2)	DE60233650D1 (xx)
DK (1)	DK1370260T3 (xx)
ES (2)	ES2353686T3 (xx)
HU (1)	HU229431B1 (xx)
IL (2)	IL156827A0 (xx)
MX (1)	MXPA03007441A (xx)
NO (1)	NO20033665L (xx)
NZ (1)	NZ526883A (xx)
PL (1)	PL204456B1 (xx)
PT (1)	PT1370260E (xx)
RU (1)	RU2258706C2 (xx)
SI (1)	SI1370260T1 (xx)
WO (2)	WO2002066034A1 (xx)

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US7709510B2 (en)	2001-02-20	2010-05-04	Chugai Seiyaku Kabushiki Kaisha	Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
MXPA03007441A (es)	2001-02-20	2004-10-15	Chugai Pharmaceutical Co Ltd	Azoles como inhibidores de malonil-coa descarboxilasa utiles como modulares metabolicos.
WO2003090746A1 (en) *	2002-04-23	2003-11-06	Chugai Seiyaku Kabushiki Kaisha	1,3-thiazoles as lxr modulators in the treatment of cardiovascular diseases
EP1648564B1 (en) *	2003-08-01	2007-10-17	Chugai Seiyaku Kabushiki Kaisha	Cyanoamide compounds useful as malonyl-coa decarboxylase inhibitors
ES2353306T3 (es) *	2003-08-01	2011-03-01	Chugai Seiyaku Kabushiki Kaisha	Compuestos heterocíclicos útiles como inhibidores de la malonil-coa-descarboxilasa.
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2002
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Also Published As

Publication number	Publication date
PL204456B1 (pl)	2010-01-29
PT1370260E (pt)	2011-02-01
EP1379243A1 (en)	2004-01-14
JP4159361B2 (ja)	2008-10-01
US7723366B2 (en)	2010-05-25
JP2004522772A (ja)	2004-07-29
WO2002066035A3 (en)	2002-10-24
DE60238391D1 (de)	2011-01-05
NO20033665L (no)	2003-10-20
HK1062633A1 (en)	2004-11-19
DE60233650D1 (de)	2009-10-22
HUP0303272A2 (hu)	2004-01-28
CN1492762A (zh)	2004-04-28
CA2437409A1 (en)	2002-08-29
ATE489089T1 (de)	2010-12-15
RU2003128307A (ru)	2005-03-10
PL362274A1 (en)	2004-10-18
EP1370260B1 (en)	2010-11-24
MXPA03007441A (es)	2004-10-15
EP1379243B1 (en)	2009-09-09
CA2437409C (en)	2010-10-19
ATE442141T1 (de)	2009-09-15
AU2002251987B2 (en)	2005-02-17
JP4879152B2 (ja)	2012-02-22
BR0207408A (pt)	2004-02-25
KR100659427B1 (ko)	2006-12-18
ES2330417T3 (es)	2009-12-10
KR20030077015A (ko)	2003-09-29
WO2002066034A1 (en)	2002-08-29
US20040082564A1 (en)	2004-04-29
CN100383132C (zh)	2008-04-23
WO2002066035A2 (en)	2002-08-29
ES2353686T3 (es)	2011-03-04
CY1110986T1 (el)	2015-06-11
NO20033665D0 (no)	2003-08-19
JP4842247B2 (ja)	2011-12-21
DK1370260T3 (da)	2011-03-14
HU229431B1 (en)	2013-12-30
IL156827A (en)	2013-12-31
JP2008120816A (ja)	2008-05-29
JP4155351B2 (ja)	2008-09-24
SI1370260T1 (sl)	2011-02-28
JP2004522773A (ja)	2004-07-29
NZ526883A (en)	2005-11-25
HUP0303272A3 (en)	2007-03-28
RU2258706C2 (ru)	2005-08-20
EP1370260A2 (en)	2003-12-17
JP2008115188A (ja)	2008-05-22

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