IL98596A0 - Insulin analogues having prolonged action,their preparation and injectable solutions containing them - Google Patents

Insulin analogues having prolonged action,their preparation and injectable solutions containing them

Info

Publication number: IL98596A0
Authority: IL; Israel
Prior art keywords: preparation; injectable solutions; solutions containing; insulin analogues; prolonged action
Prior art date: 1990-06-28

Application number

IL98596A

Other languages

English (en)

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-28

Filing date

1991-06-24

Publication date

1992-07-15

1991-06-24 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1992-07-15 Publication of IL98596A0 publication Critical patent/IL98596A0/xx

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 1
230000002035 prolonged effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Toxicology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicinal Preparation (AREA)

IL98596A 1990-06-28 1991-06-24 Insulin analogues having prolonged action,their preparation and injectable solutions containing them IL98596A0 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK155690A DK155690D0 (da)	1990-06-28	1990-06-28	Nye peptider

Publications (1)

Publication Number	Publication Date
IL98596A0 true IL98596A0 (en)	1992-07-15

Family

ID=8106031

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL98596A IL98596A0 (en)	1990-06-28	1991-06-24	Insulin analogues having prolonged action,their preparation and injectable solutions containing them

Country Status (10)

Country	Link
EP (1)	EP0536245A1 (xx)
JP (1)	JPH05508406A (xx)
AU (1)	AU8054391A (xx)
DK (1)	DK155690D0 (xx)
IE (1)	IE912247A1 (xx)
IL (1)	IL98596A0 (xx)
NZ (1)	NZ238718A (xx)
PT (1)	PT98124A (xx)
WO (1)	WO1992000321A1 (xx)
ZA (1)	ZA914830B (xx)

Families Citing this family (56)

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KR100310122B1 (ko) *	1993-09-17	2002-04-24	한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느	아실화된인슐린
US5559094A (en) *	1994-08-02	1996-09-24	Eli Lilly And Company	AspB1 insulin analogs
KR19980703039A (ko) *	1995-03-17	1998-09-05	켈스버그 라아스	인슐린 유도체
US6251856B1 (en)	1995-03-17	2001-06-26	Novo Nordisk A/S	Insulin derivatives
DE19726167B4 (de)	1997-06-20	2008-01-24	Sanofi-Aventis Deutschland Gmbh	Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
US7638618B2 (en)	2001-02-20	2009-12-29	Sanofi-Aventis Deutschland Gmbh	Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
US7202059B2 (en)	2001-02-20	2007-04-10	Sanofi-Aventis Deutschland Gmbh	Fusion proteins capable of being secreted into a fermentation medium
DE10114178A1 (de)	2001-03-23	2002-10-10	Aventis Pharma Gmbh	Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10227232A1 (de)	2002-06-18	2004-01-15	Aventis Pharma Deutschland Gmbh	Saure Insulinzubereitungen mit verbesserter Stabilität
EP1708755B1 (en)	2004-01-21	2012-03-21	Novo Nordisk Health Care AG	Transglutaminase mediated conjugation of peptides
US20090306337A1 (en)	2006-07-31	2009-12-10	Novo Nordisk A/S	Pegylated, Extended Insulins
CA2663074A1 (en)	2006-09-22	2008-03-27	Novo Nordisk A/S	Protease resistant insulin analogues
CN101674812B (zh)	2007-04-30	2013-12-11	诺沃-诺迪斯克有限公司	干燥蛋白组合物的方法、干燥的蛋白组合物和包含干燥的蛋白的药物组合物
MY152979A (en)	2008-01-09	2014-12-15	Sanofi Aventis Deutschland	Novel insulin derivatives having an extremely delayed time-action profile
ES2618073T3 (es)	2008-03-14	2017-06-20	Novo Nordisk A/S	Análogos de insulina estabilizados frente a proteasas
EP2910571B1 (en)	2008-03-18	2016-10-05	Novo Nordisk A/S	Protease stabilized, acylated insulin analogues
DE102008051834A1 (de)	2008-10-17	2010-04-22	Sanofi-Aventis Deutschland Gmbh	Kombination von einem Insulin und einem GLP-1-Agonisten
DE102008053048A1 (de)	2008-10-24	2010-04-29	Sanofi-Aventis Deutschland Gmbh	Kombination von einem Insulin und einem GLP-1-Agonisten
DE102009038210A1 (de)	2009-08-20	2011-03-03	Sanofi-Aventis Deutschland Gmbh	Kombination von einem Insulin und einem GLP-1-Agonisten
EP3677275B1 (de)	2008-10-17	2024-06-12	Sanofi-Aventis Deutschland GmbH	Kombination von einem insulin und einem glp-1-agonisten
DE102008064270A1 (de) *	2008-12-20	2010-07-01	Voith Patent Gmbh	Verfahren und Vorrichtung zur Flotation einer wässrigen Faserstoffsuspension
BR112012000177B1 (pt)	2009-07-06	2021-06-01	Sanofi-Aventis Deutschland Gmbh	Formulação farmacêutica aquosa contendo metionina, processo para sua preparação, uso da mesma e medicamento para tratar diabetes mellitus
US20120232002A1 (en)	2009-07-06	2012-09-13	Sanofi-Aventis Deutschland Gmbh	Slow-acting insulin preparations
JP2012532177A (ja) *	2009-07-06	2012-12-13	サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング	熱及び振動安定性インスリン製剤
JP5732053B2 (ja)	2009-07-31	2015-06-10	サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング	持続型インスリン組成物
KR20120089843A (ko)	2009-07-31	2012-08-14	사노피-아벤티스 도이칠란트 게엠베하	인슐린 링커 접합체를 포함한 프로드럭
UY33025A (es)	2009-11-13	2011-06-30	Sanofi Aventis Deustschland Gmbh	Composicion farmaceutica que comprende un agonista de glp-1 metionina
EP3831402A1 (de)	2009-11-13	2021-06-09	Sanofi-Aventis Deutschland GmbH	Pharmazeutische zusammensetzung umfassend einen glp-1-agonisten, ein insulin und methionin
JP5931857B2 (ja) *	2010-06-23	2016-06-08	ノヴォノルディスクアー／エス	追加のジスルフィド結合を含有するインスリン誘導体
WO2011161124A1 (en) *	2010-06-23	2011-12-29	Novo Nordisk A/S	Insulin analogues containing additional disulfide bonds
EP2585483A1 (en)	2010-06-23	2013-05-01	Novo Nordisk A/S	Human insulin containing additional disulfide bonds
RU2546520C2 (ru)	2010-08-30	2015-04-10	Санофи-Авентис Дойчланд Гмбх	Применение ave0010 для производства лекарственного средства для лечения сахарного диабета 2 типа
EP2438930A1 (en)	2010-09-17	2012-04-11	Sanofi-Aventis Deutschland GmbH	Prodrugs comprising an exendin linker conjugate
WO2012123519A2 (en) *	2011-03-15	2012-09-20	Novo Nordisk A/S	Human insulin analogues and derivatives comprising cysteine substitutions
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
HUE027989T2 (en)	2011-08-29	2016-11-28	Sanofi Aventis Deutschland	A pharmaceutical composition for use in glycemic control in patients with type 2 diabetes
AR087744A1 (es)	2011-09-01	2014-04-16	Sanofi Aventis Deutschland	Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
EP2836508B1 (en)	2012-04-11	2016-06-29	Novo Nordisk A/S	Insulin formulations
US20130315891A1 (en)	2012-05-25	2013-11-28	Matthew Charles	Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
US20130323222A1 (en)	2012-06-04	2013-12-05	Matthew Charles	Human tissue kallikrein 1 glycosylation isoforms
MX360420B (es)	2012-12-19	2018-10-31	Wockhardt Ltd	Una composicion acuosa estable que comprende insulina humana o un analogo o derivado de la misma.
CA2889162A1 (en)	2012-12-26	2014-07-03	Wockhardt Limited	Pharmaceutical composition
TWI641381B (zh)	2013-02-04	2018-11-21	法商賽諾菲公司	胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物
AU2014326181A1 (en)	2013-09-30	2016-03-17	Wockhardt Limited	Pharmaceutical composition
DK3055325T3 (en)	2013-10-07	2018-04-16	Novo Nordisk As	New derivative of an insulin analogue
JP6735674B2 (ja)	2014-01-09	2020-08-05	サノフイＳａｎｏｆｉ	インスリンアスパルトの安定化された医薬製剤
CA2932877A1 (en)	2014-01-09	2015-07-16	Sanofi	Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
US9895424B2 (en)	2014-01-09	2018-02-20	Sanofi	Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
WO2016001862A1 (en)	2014-07-04	2016-01-07	Wockhardt Limited	Extended release formulations of insulins
PE20171622A1 (es)	2014-12-12	2017-11-02	Sanofi Aventis Deutschland	Formulacion de relacion fija de insulina glargina/lixisenatida
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
CN115154591B (zh)	2016-12-16	2023-04-14	诺和诺德股份有限公司	含胰岛素的药物组合物
CA3054962A1 (en)	2017-03-09	2018-09-13	Rick PAULS	Dosage forms of tissue kallikrein 1
PE20211264A1 (es)	2017-08-17	2021-07-15	Novo Nordisk As	Analogos de insulina acilados novedosos y usos de estos
CN109646396A (zh) *	2018-12-29	2019-04-19	江苏万邦医药科技有限公司	一种稳定的胰岛素类似物注射液及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2536040A1 (de) *	1975-08-13	1977-02-24	Hoechst Ag	Insulin-analoga mit biologischer wirkung
PH25772A (en) *	1985-08-30	1991-10-18	Novo Industri As	Insulin analogues, process for their preparation
DK257988D0 (da) *	1988-05-11	1988-05-11	Novo Industri As	Nye peptider
JPH04502465A (ja) *	1988-12-23	1992-05-07	ノボ　ノルディスク　アクティーゼルスカブ	ヒトインシュリン類似物質

1990
- 1990-06-28 DK DK155690A patent/DK155690D0/da not_active IP Right Cessation
1991
- 1991-06-21 WO PCT/DK1991/000167 patent/WO1992000321A1/en not_active Application Discontinuation
- 1991-06-21 EP EP91912264A patent/EP0536245A1/en not_active Withdrawn
- 1991-06-21 AU AU80543/91A patent/AU8054391A/en not_active Abandoned
- 1991-06-21 JP JP3511335A patent/JPH05508406A/ja active Pending
- 1991-06-24 IL IL98596A patent/IL98596A0/xx unknown
- 1991-06-24 ZA ZA914830A patent/ZA914830B/xx unknown
- 1991-06-26 NZ NZ238718A patent/NZ238718A/en unknown
- 1991-06-27 PT PT98124A patent/PT98124A/pt not_active Application Discontinuation
- 1991-06-27 IE IE224791A patent/IE912247A1/en unknown

Also Published As

Publication number	Publication date
PT98124A (pt)	1992-04-30
ZA914830B (en)	1992-03-25
EP0536245A1 (en)	1993-04-14
NZ238718A (en)	1992-06-25
DK155690D0 (da)	1990-06-28
JPH05508406A (ja)	1993-11-25
WO1992000321A1 (en)	1992-01-09
AU8054391A (en)	1992-01-23
IE912247A1 (en)	1992-01-01

Publication	Publication Date	Title
IL98596A0 (en)	1992-07-15	Insulin analogues having prolonged action,their preparation and injectable solutions containing them
ZA893508B (en)	1990-01-31	Insulin analogues
GR3023268T3 (en)	1997-07-30	Hypodermic syringe
GB9100677D0 (en)	1991-03-06	Hypodermic syringe
ZA895951B (en)	1990-04-25	Syringe
GB2239608B (en)	1993-01-20	Hypodermic syringe
ZA906383B (en)	1991-04-24	Long active injectable formulations containing triacetin
GB8800231D0 (en)	1988-02-10	Syringe
AU107847S (en)	1990-06-12	Syringe
GB8809410D0 (en)	1988-05-25	Syringe pump
GB8824100D0 (en)	1988-11-23	Syringe
GB8810955D0 (en)	1988-06-15	Syringe
IL111437A0 (en)	1994-12-29	Insulin analogues
GB8925583D0 (en)	1990-01-04	Mono-use syringe
RO101670B1 (en)	1992-05-07	Medical composition with miocardioprotective action
GB2241893B (en)	1994-01-05	Hypodermic syringe
IE894150L (en)	1990-06-23	Human insulin analogues
GB2215404B (en)	1991-07-03	Syringe
ZA899501B (en)	1990-09-26	Human insulin analogues
IE860956L (en)	1986-10-15	Administering insulin
AR243771A1 (es)	1993-09-30	Jeringas hipodermicas autodescartables
GB9015660D0 (en)	1990-09-05	Hypodermic syringe
GB9005351D0 (en)	1990-05-02	Hypodermic syringe
GB9026508D0 (en)	1991-01-23	Hypodermic syringe
IE900016L (en)	1990-07-04	Hypodermic syringe