IL99598A - INTERLEUKIN-1beta PROTEASE INHIBITORS AND PHARMACEUTICAL COMPOSITIONS THEREOF - Google Patents

INTERLEUKIN-1beta PROTEASE INHIBITORS AND PHARMACEUTICAL COMPOSITIONS THEREOF

Info

Publication number: IL99598A
Authority: IL; Israel
Prior art keywords: asp; amino acid; interleukin; 1beta; pharmaceutical compositions
Prior art date: 1991-08-30

Application number

IL9959891A

Other languages

English (en)

Other versions

IL99598A0 (en

Original Assignee

Vertex Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-08-30

Filing date

1991-09-27

Publication date

2005-06-19

1991-09-27 Application filed by Vertex Pharma filed Critical Vertex Pharma

1992-08-18 Publication of IL99598A0 publication Critical patent/IL99598A0/xx

2005-06-19 Publication of IL99598A publication Critical patent/IL99598A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/8142—Aspartate protease (E.C. 3.4.23) inhibitors, e.g. HIV protease inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/545—IL-1
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6472—Cysteine endopeptidases (3.4.22)
- C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
Gastroenterology & Hepatology (AREA)
Wood Science & Technology (AREA)
Immunology (AREA)
Crystallography & Structural Chemistry (AREA)
Microbiology (AREA)
Dermatology (AREA)
General Engineering & Computer Science (AREA)
AIDS & HIV (AREA)
Toxicology (AREA)
Hematology (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Biotechnology (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Nutrition Science (AREA)
Obesity (AREA)

IL9959891A 1991-08-30 1991-09-27 INTERLEUKIN-1beta PROTEASE INHIBITORS AND PHARMACEUTICAL COMPOSITIONS THEREOF IL99598A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US75064491A	1991-08-30	1991-08-30

Publications (2)

Publication Number	Publication Date
IL99598A0 IL99598A0 (en)	1992-08-18
IL99598A true IL99598A (en)	2005-06-19

Family

ID=25018683

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL9959891A IL99598A (en)	1991-08-30	1991-09-27	INTERLEUKIN-1beta PROTEASE INHIBITORS AND PHARMACEUTICAL COMPOSITIONS THEREOF
IL16679105A IL166791A0 (en)	1991-08-30	2005-02-09	Interleukin-1? protease inhibitors and pharmaceutical compositions thereof

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL16679105A IL166791A0 (en)	1991-08-30	2005-02-09	Interleukin-1? protease inhibitors and pharmaceutical compositions thereof

Country Status (21)

Country	Link
US (2)	US5756465A (xx)
EP (2)	EP1378573A1 (xx)
JP (3)	JP2759895B2 (xx)
KR (1)	KR100226296B1 (xx)
AT (1)	ATE257517T1 (xx)
AU (1)	AU657701B2 (xx)
CA (1)	CA2111100C (xx)
DE (1)	DE69133354T2 (xx)
DK (1)	DK0600880T3 (xx)
ES (1)	ES2213138T3 (xx)
FI (1)	FI935020L (xx)
HU (1)	HU220098B (xx)
IE (1)	IE913268A1 (xx)
IL (2)	IL99598A (xx)
MX (1)	MX9101346A (xx)
MY (1)	MY131144A (xx)
NO (1)	NO317129B1 (xx)
NZ (3)	NZ239895A (xx)
PT (1)	PT99118B (xx)
RU (2)	RU2206611C2 (xx)
WO (1)	WO1993005071A1 (xx)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5874424A (en) *	1995-12-20	1999-02-23	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β converting enzyme
US6008217A (en) *	1995-12-20	1999-12-28	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β converting enzyme
US6204261B1 (en)	1995-12-20	2001-03-20	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β Converting enzyme inhibitors
US6995141B1 (en)	1990-04-04	2006-02-07	Vertex Pharmaceuticals Incorporated	Interleukin 1β protease and interleukin 1β protease inhibitors
HU220098B (hu) *	1991-08-30	2001-10-28	Vertex Pharmaceuticals Incorporated	Interleukin-1 béta proteáz enzim, és interleukin-1 béta proteáz inhibitorok
IL105741A0 (en) *	1992-05-22	1993-09-22	Genta Inc	Pharmaceutical compositions for treating cellular hyperproliferation using interleukin-1 inhibitory compounds
US5462939A (en) *	1993-05-07	1995-10-31	Sterling Winthrop Inc.	Peptidic ketones as interleukin-1β-converting enzyme inhibitors
JPH0789951A (ja) *	1993-06-03	1995-04-04	Sterling Winthrop Inc	インターロイキン−１β転換酵素阻害剤
EP0644197B1 (en) *	1993-06-04	1998-09-09	Vertex Pharmaceuticals Incorporated	Peptidic phosphinyloxymethyl ketones as interleukin-1beta-converting enzyme inhibitors
US5843905A (en) *	1993-06-04	1998-12-01	Vertex Pharmaceuticals, Incorporated	Peptidic phosphinyloxymethyl ketones as interleukin-1β-converting enzyme inhibitors
US6087160A (en) *	1993-06-24	2000-07-11	The General Hospital Corporation	Programmed cell death genes and proteins
US6083735A (en) *	1993-06-24	2000-07-04	The General Hospital Corporation	Programmed cell death genes and proteins
US5756466A (en) *	1994-06-17	1998-05-26	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1β converting enzyme
US6420522B1 (en)	1995-06-05	2002-07-16	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β converting enzyme
US5716929A (en) *	1994-06-17	1998-02-10	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1β converting enzyme
US5847135A (en) *	1994-06-17	1998-12-08	Vertex Pharmaceuticals, Incorporated	Inhibitors of interleukin-1β converting enzyme
US5955072A (en) *	1994-07-13	1999-09-21	Sankyo Company, Limited	Expression systems utilizing autolyzing fusion proteins and a reducing polypeptide
JPH10509586A (ja) *	1994-10-14	1998-09-22	ベーアーエスエフアクツィエンゲゼルシャフト	機能的に破壊されたインターロイキン−１β変換酵素遺伝子を有するトランスジェニック非ヒト動物
CA2215211A1 (en) *	1995-03-31	1996-10-03	Takeda Chemical Industries, Ltd.	Cysteine protease inhibitor
US5869315A (en)	1995-12-18	1999-02-09	Basf Aktiengesellschaft	Modified interleukin-1β converting enzyme with increased stability
US5843904A (en) *	1995-12-20	1998-12-01	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1βconverting enzyme
US6288037B1 (en)	1996-01-29	2001-09-11	Basf Aktiengesellschaft	Substrates and inhibitors for cysteine protease ICH-1
US6416753B1 (en)	1996-03-15	2002-07-09	The General Hospital Corporation	Method for modulating apoptosis
US6200969B1 (en)	1996-09-12	2001-03-13	Idun Pharmaceuticals, Inc.	Inhibition of apoptosis using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors
US6610683B2 (en) *	1996-09-12	2003-08-26	Idun Pharmaceuticals, Inc.	Treatment of infectious disease using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors
US6531467B2 (en)	1996-09-12	2003-03-11	Idun Pharmaceuticals, Inc.	Inhibition of inflammation using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors
US6184244B1 (en)	1996-12-16	2001-02-06	Idun Pharmaceuticals, Inc.	C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US6054487A (en) *	1997-03-18	2000-04-25	Basf Aktiengesellschaft	Methods and compositions for modulating responsiveness to corticosteroids
BR9814817A (pt) *	1997-10-10	2002-01-08	Cytovia Inc	Inibidores de apoptose de dipeptìdio e o uso dos mesmos
US6184210B1 (en)	1997-10-10	2001-02-06	Cytovia, Inc.	Dipeptide apoptosis inhibitors and the use thereof
JP4499917B2 (ja)	1998-03-09	2010-07-14	バーテックスファーマシューティカルズインコーポレイテッド	インターロイキン−１β変換酵素のインヒビターとしての１，２−ジアゼパン誘導体
EP1076563B1 (en) *	1998-03-16	2005-05-11	Cytovia, Inc.	Dipeptide caspase inhibitors and the use thereof
WO1999047545A2 (en)	1998-03-19	1999-09-23	Vertex Pharmaceuticals Incorporated	Inhibitors of caspases
DE60030097T2 (de)	1999-03-16	2007-03-08	Cytovia, Inc., San Diego	Substituierte 2-aminobenzamin caspase inhibitoren und ihre verwendung
DE19915465A1 (de) *	1999-04-06	2000-10-19	Apotech Res & Dev Ltd	Verwendung eines Caspase-Inhibitors zur Proliferationshemmung von Zellen und Verwendung eines oder mehrerer Caspase-Inhibitors/en zur Behandlung von Erkrankungen beruhend auf Lymphozyten-Hyperproliferation oder zur Suppression einer Immunantwort durch Lymphozyten
EP1177168B1 (en)	1999-04-09	2007-05-30	Cytovia, Inc.	Caspase inhibitors and the use thereof
IL146923A0 (en) *	1999-06-14	2002-08-14	Wisconsin Alumni Res Found	Oligomers and polymers of cyclic imino carboxylic acids
MXPA02002038A (es)	1999-08-27	2002-10-31	Cytovia Inc	Acidos alfa-hidroxi substituidores inhibidores de la caspasa y uso de los mismos.
US6566338B1 (en)	1999-10-12	2003-05-20	Cytovia, Inc.	Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death
EP1923386A3 (en)	2000-03-29	2008-05-28	Vertex Pharmceuticals Incorporated	Carbamate caspase inhibitors and uses thereof
EP1268425B1 (en)	2000-03-29	2008-01-23	Vertex Pharmaceuticals Incorporated	Carbamate caspase inhibitors and uses thereof
US20010053764A1 (en) *	2000-05-12	2001-12-20	Sims John E.	Interleukin-1 inhibitors in the treatment of diseases
PE20011350A1 (es)	2000-05-19	2002-01-15	Vertex Pharma	PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
EA006860B1 (ru) *	2002-01-29	2006-04-28	Уайт	Композиции и способы модулирования гемиканалов коннексина
JP2005536462A (ja)	2002-04-30	2005-12-02	ユンジンファーマスーチカルインダストリーズカンパニーリミテッド	カスパーゼ−３阻害剤としてのキノリン誘導体、この製造方法及びこれを含む薬剤学的組成物
CN1886126A (zh) *	2003-09-25	2006-12-27	Dmi生物科学公司	利用n－酰基－l－天冬氨酸的方法和产品
AU2005249503B2 (en)	2003-11-10	2011-08-25	Vertex Pharmaceuticals Incorporated	ICE inhibitors for the treatment of autoinflammatory diseases
MXPA06013256A (es) *	2004-05-15	2007-02-08	Vertex Pharma	Tratamiento de crisis convulsivas utilizando inhibidores ice.
GB0411056D0 (en)	2004-05-18	2004-06-23	Novartis Ag	Organic compounds
US7618801B2 (en) *	2007-10-30	2009-11-17	Danison US Inc.	Streptomyces protease
WO2012061785A2 (en)	2010-11-05	2012-05-10	Brandeis University	Ice inhibiting compounds and uses thereof
US9956260B1 (en)	2011-07-22	2018-05-01	The J. David Gladstone Institutes	Treatment of HIV-1 infection and AIDS
WO2025096931A1 (en) *	2023-11-01	2025-05-08	64-X, Inc.	Production technologies

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GB2124233B (en) *	1982-07-19	1985-09-18	Nat Res Dev	Synthetic peptides and their preparation
US4636492A (en) *	1984-08-29	1987-01-13	E. I. Du Pont De Nemours And Company	Inhibition of viral protease activity by peptide halomethyl ketones
US5104853A (en) *	1984-12-11	1992-04-14	California Biotechnology Inc.	Alveolar surfactant proteins having cys to ser mutations
US4644055A (en) *	1984-12-17	1987-02-17	E. I. Du Pont De Nemours And Company	Method for preparing specific inhibitors of virus-specified proteases
JPS63145300A (ja) *	1984-12-17	1988-06-17	イ−・アイ・デユポン・デ・ニモアス・アンド・カンパニ−	ウイルスにより特定されているプロテア−ゼの特異的阻害剤を製造する方法
US5225354A (en) *	1986-08-22	1993-07-06	Molecular Diagnostics, Inc.	Monoclonal antibodies specific for human glycoalbumin
WO1991000912A1 (en) *	1989-07-07	1991-01-24	Massachusetts Institute Of Technology	Production and use of hybrid protease inhibitors
AU7775991A (en) *	1990-04-04	1991-10-30	Immunex Corporation	Interleukin 1beta protease
US5298421A (en) *	1990-04-26	1994-03-29	Calgene, Inc.	Plant medium-chain-preferring acyl-ACP thioesterases and related methods
EP0533350B1 (en) *	1991-08-16	1999-05-26	Merck & Co. Inc.	DNA encoding precursor interleukin 1B converting enzyme
HU220098B (hu) *	1991-08-30	2001-10-28	Vertex Pharmaceuticals Incorporated	Interleukin-1 béta proteáz enzim, és interleukin-1 béta proteáz inhibitorok

1991
- 1991-09-12 HU HU9303244A patent/HU220098B/hu not_active IP Right Cessation
- 1991-09-12 KR KR1019940700644A patent/KR100226296B1/ko not_active Expired - Fee Related
- 1991-09-12 WO PCT/US1991/006595 patent/WO1993005071A1/en active IP Right Grant
- 1991-09-12 ES ES91916780T patent/ES2213138T3/es not_active Expired - Lifetime
- 1991-09-12 JP JP3515380A patent/JP2759895B2/ja not_active Expired - Lifetime
- 1991-09-12 RU RU94028712/13A patent/RU2206611C2/ru not_active IP Right Cessation
- 1991-09-12 CA CA002111100A patent/CA2111100C/en not_active Expired - Lifetime
- 1991-09-12 AU AU85373/91A patent/AU657701B2/en not_active Expired
- 1991-09-12 DE DE69133354T patent/DE69133354T2/de not_active Expired - Lifetime
- 1991-09-12 AT AT91916780T patent/ATE257517T1/de not_active IP Right Cessation
- 1991-09-12 DK DK91916780T patent/DK0600880T3/da active
- 1991-09-12 EP EP03018990A patent/EP1378573A1/en not_active Withdrawn
- 1991-09-12 FI FI935020A patent/FI935020L/fi not_active Application Discontinuation
- 1991-09-12 EP EP91916780A patent/EP0600880B1/en not_active Expired - Lifetime
- 1991-09-16 IE IE326891A patent/IE913268A1/en not_active IP Right Cessation
- 1991-09-18 MY MYPI91001693A patent/MY131144A/en unknown
- 1991-09-23 NZ NZ239895A patent/NZ239895A/en not_active IP Right Cessation
- 1991-09-23 NZ NZ248377A patent/NZ248377A/xx not_active IP Right Cessation
- 1991-09-23 NZ NZ335312A patent/NZ335312A/en not_active IP Right Cessation
- 1991-09-27 IL IL9959891A patent/IL99598A/xx not_active IP Right Cessation
- 1991-09-30 PT PT99118A patent/PT99118B/pt not_active IP Right Cessation
- 1991-09-30 MX MX9101346A patent/MX9101346A/es not_active IP Right Cessation
1993
- 1993-11-30 NO NO19934335A patent/NO317129B1/no unknown
1995
- 1995-05-12 US US08/440,179 patent/US5756465A/en not_active Expired - Lifetime
1997
- 1997-03-03 JP JP9061701A patent/JPH1028588A/ja active Pending
1998
- 1998-03-16 US US09/039,657 patent/US6136787A/en not_active Expired - Lifetime
2000
- 2000-11-09 JP JP2000342474A patent/JP3445572B2/ja not_active Expired - Lifetime
2002
- 2002-10-25 RU RU2002128757/13A patent/RU2002128757A/ru not_active Application Discontinuation
2005
- 2005-02-09 IL IL16679105A patent/IL166791A0/xx unknown

Also Published As

Publication number	Publication date
IL166791A0 (en)	2006-01-15
JP3445572B2 (ja)	2003-09-08
HU9303244D0 (en)	1994-03-28
EP0600880A4 (en)	1994-12-21
FI935020A7 (fi)	1993-12-03
DE69133354T2 (de)	2004-11-11
FI935020A0 (fi)	1993-11-12
NO317129B1 (no)	2004-08-23
PT99118A (pt)	1993-02-26
JPH1028588A (ja)	1998-02-03
PT99118B (pt)	1999-02-26
RU2206611C2 (ru)	2003-06-20
NZ239895A (en)	1996-01-26
CA2111100C (en)	2004-11-02
RU94028712A (ru)	1997-03-10
RU2002128757A (ru)	2004-07-27
ES2213138T3 (es)	2004-08-16
NO934335D0 (no)	1993-11-30
AU657701B2 (en)	1995-03-23
NZ335312A (en)	2005-08-26
AU8537391A (en)	1993-04-05
JP2759895B2 (ja)	1998-05-28
MY131144A (en)	2007-07-31
HK1014013A1 (en)	1999-09-17
DE69133354D1 (de)	2004-02-12
KR100226296B1 (ko)	1999-10-15
HUT66057A (en)	1994-09-28
US6136787A (en)	2000-10-24
CA2111100A1 (en)	1993-03-18
JPH08505280A (ja)	1996-06-11
MX9101346A (es)	1993-02-01
IE913268A1 (en)	1993-03-10
EP1378573A1 (en)	2004-01-07
WO1993005071A1 (en)	1993-03-18
NO934335L (no)	1993-11-30
EP0600880B1 (en)	2004-01-07
US5756465A (en)	1998-05-26
HU220098B (hu)	2001-10-28
EP0600880A1 (en)	1994-06-15
FI935020L (fi)	1993-12-03
IL99598A0 (en)	1992-08-18
NZ248377A (en)	2000-01-28
DK0600880T3 (da)	2004-04-13
ATE257517T1 (de)	2004-01-15
JP2001192397A (ja)	2001-07-17

Publication	Publication Date	Title
IL99598A (en)	2005-06-19	INTERLEUKIN-1beta PROTEASE INHIBITORS AND PHARMACEUTICAL COMPOSITIONS THEREOF
Simmer et al.	1998	Purification, characterization, and cloning of enamel matrix serine proteinase 1
DE10075019I2 (de)	2005-06-23	Neue Proteine mit TNF-Hemmender Wirkung und ihre Herstellung.
EP1197220A3 (en)	2009-04-15	Therapeutic methods and compositions based on delta proteins and nucleic acids
FI842166L (fi)	1984-05-30	Bukspottskoertelns grf hos maenniskan.
KR900017607A (ko)	1990-12-19	프로테이나아제 억제제, 이것의 제조방법 및 이들을 함유한 의약품
EP0202853A3 (en)	1988-07-20	A polypeptide which neutralises the activity of factor viii inhibitor and a therapeutic composition containing it
GR860398B (en)	1986-06-12	Process for obtaining peptidic derivatives of renine inhibitors and proteases acids
ATE97421T1 (de)	1993-12-15	Gentechnologisch hergestellter pankreatischer sekretorischer trypsininhibitor und seine varianten.
EP0187721A3 (en)	1988-11-23	Preparation of peptide substrates for virus-specified proteases
BR9306272A (pt)	1998-06-23	Peptídeo e composiçao farmacêutica
LV10108A (lv)	1994-05-10	Sunu proliferacijas inhibitori farmaceitiska kompozicija savienojumu iegusanas metode sunu proliferacijas inhibesanas panemieni
ES2015366A6 (es)	1990-08-16	Procedimientos para producir y modificar polipeptidos inhibidores de elastasa y proteinas fusionadas.
AU5232886A (en)	1986-07-01	Serine protease inhibitors and methods for isolation of same
DK0561877T3 (da)	1999-12-27	Forbindelser og præparater der hæmmer knogleresorption
EP0352816A3 (en)	1991-03-20	Il-1alpha derivates and medicament for treating thrombocytopenia
ATE140234T1 (de)	1996-07-15	Neue inhibitorische peptide
ATE110389T1 (de)	1994-09-15	Thf-zusammensetzungen.
ATE82984T1 (de)	1992-12-15	Hemmende peptide.
MX9206055A (es)	1993-04-01	Nuevas proteinas inhibidoras de trombina de garrapatas

Legal Events

Date	Code	Title
1999-12-22	HC	Change of name of proprietor(s)
2006-01-15	FF	Patent granted
2006-03-12	KB	Patent renewed
2010-11-30	MM9K	Patent not in force due to non-payment of renewal fees