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IT1293827B1 - Metodo per l'espansione ex vivo di cellule staminali emopoietiche - Google Patents

Metodo per l'espansione ex vivo di cellule staminali emopoietiche

Info

Publication number
IT1293827B1
IT1293827B1 IT97MI001898A ITMI971898A IT1293827B1 IT 1293827 B1 IT1293827 B1 IT 1293827B1 IT 97MI001898 A IT97MI001898 A IT 97MI001898A IT MI971898 A ITMI971898 A IT MI971898A IT 1293827 B1 IT1293827 B1 IT 1293827B1
Authority
IT
Italy
Prior art keywords
stem cells
hematopoietic stem
vivo expansion
vivo
expansion
Prior art date
Application number
IT97MI001898A
Other languages
English (en)
Inventor
Lorenza Lazzari
Paolo Rebulla
Girolamo Sirchia
Original Assignee
Dompe Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dompe Spa filed Critical Dompe Spa
Priority to IT97MI001898A priority Critical patent/IT1293827B1/it
Priority to AU88087/98A priority patent/AU8808798A/en
Priority to PCT/EP1998/004882 priority patent/WO1999007831A1/en
Publication of ITMI971898A1 publication Critical patent/ITMI971898A1/it
Application granted granted Critical
Publication of IT1293827B1 publication Critical patent/IT1293827B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/145—Thrombopoietin [TPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IT97MI001898A 1997-08-07 1997-08-07 Metodo per l'espansione ex vivo di cellule staminali emopoietiche IT1293827B1 (it)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IT97MI001898A IT1293827B1 (it) 1997-08-07 1997-08-07 Metodo per l'espansione ex vivo di cellule staminali emopoietiche
AU88087/98A AU8808798A (en) 1997-08-07 1998-08-05 Method for the ex-vivo expansion of hematopoietic stem cells
PCT/EP1998/004882 WO1999007831A1 (en) 1997-08-07 1998-08-05 Method for the ex-vivo expansion of hematopoietic stem cells

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI001898A IT1293827B1 (it) 1997-08-07 1997-08-07 Metodo per l'espansione ex vivo di cellule staminali emopoietiche

Publications (2)

Publication Number Publication Date
ITMI971898A1 ITMI971898A1 (it) 1999-02-07
IT1293827B1 true IT1293827B1 (it) 1999-03-10

Family

ID=11377736

Family Applications (1)

Application Number Title Priority Date Filing Date
IT97MI001898A IT1293827B1 (it) 1997-08-07 1997-08-07 Metodo per l'espansione ex vivo di cellule staminali emopoietiche

Country Status (3)

Country Link
AU (1) AU8808798A (it)
IT (1) IT1293827B1 (it)
WO (1) WO1999007831A1 (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000018885A1 (en) 1998-09-29 2000-04-06 Gamida Cell Ltd. Methods of controlling proliferation and differentiation of stem and progenitor cells
WO2001032841A2 (en) * 1999-10-29 2001-05-10 The Government Of The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services Method of in vitro t cell differentiation of cd34+ progenitor cells
CA2472019A1 (en) * 2001-11-09 2003-05-22 Viacell, Inc. Production of cell suspensions
DE10158680B4 (de) * 2001-11-30 2004-04-08 Universitätsklinikum Hamburg-Eppendorf Verfahren zur ex vivo-Expansion und -Differenzierung von multipotenten Stammzellen
EP1465982A4 (en) 2002-01-25 2006-06-07 Gamida Cell Ltd PROCESS FOR EXPANSION OF STEM AND PRESERVATIVE CELLS AND EXPANDED CELL POPULATIONS THEREWITH OBTAINED
DE10227611A1 (de) * 2002-06-20 2004-01-15 Bionethos Holding Gmbh Verfahren und Vorrichtung zur Vermehrung und Differenzierung von Zellen in Anwesenheit von Wachstumsfaktoren und einer biologischen Matrix oder Trägerstruktur
US8846393B2 (en) 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment
CN104204193B (zh) 2012-02-13 2016-10-26 加米达细胞有限公司 间充质干细胞的培养
US9567569B2 (en) 2012-07-23 2017-02-14 Gamida Cell Ltd. Methods of culturing and expanding mesenchymal stem cells
US9175266B2 (en) 2012-07-23 2015-11-03 Gamida Cell Ltd. Enhancement of natural killer (NK) cell proliferation and activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ314644A (en) * 1993-05-24 2000-11-24 Immunex Corp Use of flt3-ligands as a growth stimulator of stem cells in the transplantation of tissue
US6060052A (en) * 1995-10-30 2000-05-09 Systemix, Inc. Methods for use of Mpl ligands with primitive human hematopoietic stem cells

Also Published As

Publication number Publication date
AU8808798A (en) 1999-03-01
ITMI971898A1 (it) 1999-02-07
WO1999007831A1 (en) 1999-02-18

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Legal Events

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0001 Granted