IT1299202B1 - Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo - Google Patents
Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodoInfo
- Publication number
- IT1299202B1 IT1299202B1 IT98MI001005A ITMI981005A IT1299202B1 IT 1299202 B1 IT1299202 B1 IT 1299202B1 IT 98MI001005 A IT98MI001005 A IT 98MI001005A IT MI981005 A ITMI981005 A IT MI981005A IT 1299202 B1 IT1299202 B1 IT 1299202B1
- Authority
- IT
- Italy
- Prior art keywords
- hydroxy
- oxopropyl
- amino
- bis
- ethyl
- Prior art date
Links
- -1 (2-HYDROXY-1-OXOPROPYL) AMINO Chemical class 0.000 title abstract 3
- 125000001495 ethyl group Chemical class [H]C([H])([H])C([H])([H])* 0.000 title 1
- 239000002904 solvent Substances 0.000 abstract 2
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 abstract 1
- 229940035437 1,3-propanediol Drugs 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/16—Preparation of optical isomers
- C07C231/18—Preparation of optical isomers by stereospecific synthesis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epoxy Compounds (AREA)
Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT98MI001005A IT1299202B1 (it) | 1998-05-08 | 1998-05-08 | Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo |
| EP19990924824 EP1075462B1 (en) | 1998-05-08 | 1999-04-26 | Process for the preparation of s- n,n'- bis[2- hydroxy-1- (hydroxymethyl) ethyl]-5- [(2- hydroxy-1- oxopropyl)- amino]- 2,4,6- triiodo- 1,3- benzenedicarboxamide |
| AT99924824T ATE243676T1 (de) | 1998-05-08 | 1999-04-26 | Verfahren zur herstellung von s-n,n'-bis (2- hydroxy-1-(hydroxymethyl)ethyl)-5-((2-hydroxy-1 oxopropyl)-amino)-2,4,6-triiodo-1,3- benzenedicarboxamid |
| DE69909078T DE69909078T2 (de) | 1998-05-08 | 1999-04-26 | Verfahren zur herstellung von s-n,n'-bis [2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)-amino]-2,4,6-triiodo-1,3-benzenedicarboxamid |
| PT99924824T PT1075462E (pt) | 1998-05-08 | 1999-04-26 | Processo para a preparacao de s-n,n'-bis¬2-hidroxi-1-(hidroximetil)-etil|-5-¬2-hidroxi-1-oxopropil-amino|-2,4,6-tri-iodo-1,3-benzenodicarboxamida |
| ES99924824T ES2201719T3 (es) | 1998-05-08 | 1999-04-26 | Procedimiento para la preparacion de s-n-n`-bis (2-hidroxi-1-(hidroximetil)etil)-s-((2-hidroxi-1-oxopropil)-amino)-2,4,6-triyodo-1,3-bencenodicarboxamida`. |
| KR1020007012448A KR100612480B1 (ko) | 1998-05-08 | 1999-04-26 | Ｓ-ｎ,ｎ'-비스[2-히드록시-1-(히드록시메틸)에틸]-5-[(2-히드록시-1-옥소프로필)-아미노]-2,4,6-트리요오도-1,3-벤젠디카르복사미드의 제조방법 |
| CZ20004124A CZ293801B6 (cs) | 1998-05-08 | 1999-04-26 | Způsob výroby S@NŹN´@bis@[@@hydroxy@�@}hydroxymethylBethyl]@Q@[}@@hydroxy@�@oxopropylBamino]@@Ź@Ź@@trijod@�Ź@@benzendikarboxamidu |
| DK99924824T DK1075462T3 (da) | 1998-05-08 | 1999-04-26 | Fremgangsmåde til fremstilling af S-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiod-1,3-benzendicarboxamid. |
| PCT/EP1999/002804 WO1999058494A2 (en) | 1998-05-08 | 1999-04-26 | Process for the preparation of s- n,n'- bis[2- hydroxy-1- (hydroxymethyl) ethyl]-5- [(2- hydroxy-1- oxopropyl)- amino]- 2,4,6- triiodo- 1,3- benzenedicarboxamide |
| AU41356/99A AU749785B2 (en) | 1998-05-08 | 1999-04-26 | Process for the preparation of S- N,N'- BIS(2- hydroxy-1- (hydroxymethyl) ethyl)-5- ((2- hydroxy-1- oxopropyl)- amino)- 2,4,6- triiodo- 1,3- benzenedicarboxamide |
| CA002331660A CA2331660C (en) | 1998-05-08 | 1999-04-26 | Process for the preparation of s-n,n'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)-amino]-2,4,6-triiodo-1,3-benzenedicarboxamide |
| JP2000548298A JP4390389B2 (ja) | 1998-05-08 | 1999-04-26 | Ｓ−ｎ，ｎ′−ビス〔２−ヒドロキシ−１−（ヒドロキシメチル）エチル〕−５−〔（２−ヒドロキシ−１−オキソプロピル）アミノ〕−２，４，６−トリヨード−１，３−ベンゼンジカルボキシアミドを製造する方法 |
| CNB998059226A CN100336800C (zh) | 1998-05-08 | 1999-04-26 | S－n,n′－双[2－羟基－1－(羟甲基)乙基]－5－[(2－羟基－1－氧代丙基)氨基]－2,4,6－三碘－1,3－苯二甲酰胺的制备方法 |
| NO20005616A NO326203B1 (no) | 1998-05-08 | 2000-11-07 | Fremgangsmate for fremstilling av S-N,N'-bis[2-hydroksy-1-(hydroksymetyl)etyl]-[5-[(2-hydroksy-1-oksopropyl)-amino]-2,4,6-trijod-1,3-benzendikarboksamid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT98MI001005A IT1299202B1 (it) | 1998-05-08 | 1998-05-08 | Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ITMI981005A1 ITMI981005A1 (it) | 1999-11-08 |
| IT1299202B1 true IT1299202B1 (it) | 2000-02-29 |
Family
ID=11379983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT98MI001005A IT1299202B1 (it) | 1998-05-08 | 1998-05-08 | Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1075462B1 (it) |
| JP (1) | JP4390389B2 (it) |
| KR (1) | KR100612480B1 (it) |
| CN (1) | CN100336800C (it) |
| AT (1) | ATE243676T1 (it) |
| AU (1) | AU749785B2 (it) |
| CA (1) | CA2331660C (it) |
| CZ (1) | CZ293801B6 (it) |
| DE (1) | DE69909078T2 (it) |
| DK (1) | DK1075462T3 (it) |
| ES (1) | ES2201719T3 (it) |
| IT (1) | IT1299202B1 (it) |
| NO (1) | NO326203B1 (it) |
| PT (1) | PT1075462E (it) |
| WO (1) | WO1999058494A2 (it) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101098553B1 (ko) * | 2008-04-30 | 2011-12-26 | 주식회사 엘지생명과학 | 이오프로마이드의 신규한 제조방법 |
| PL2365963T3 (pl) * | 2008-11-18 | 2017-12-29 | Bracco Imaging S.P.A | Sposób przygotowywania jodowanych środków kontrastowych |
| EP2230227A1 (en) | 2009-03-20 | 2010-09-22 | Bracco Imaging S.p.A | Process for the preparation of triiodinated carboxylic aromatic derivatives |
| CA2897700C (en) | 2012-12-11 | 2022-05-03 | Bracco Imaging S.P.A. | Continuous process for the preparation of (s)-2-acetyloxypropionic acid chloride |
| HRP20181122T1 (hr) | 2013-11-05 | 2018-09-21 | Bracco Imaging S.P.A | Postupak za pripremu jopamidola |
| AU2015273640B2 (en) | 2014-06-10 | 2019-01-24 | Bracco Imaging Spa | Method for the preparation of (S)-2-acetyloxypropionic acid and derivatives thereof |
| CN105272899B (zh) * | 2015-11-17 | 2017-09-22 | 浙江海洲制药有限公司 | 一种化合物及其用于合成碘帕醇杂质d、杂质f、杂质g和杂质j的方法 |
| JP7012722B2 (ja) | 2016-12-05 | 2022-01-28 | ブラッコ・イメージング・ソシエタ・ペル・アチオニ | 放射線画像診断剤中間体の機械化学的合成 |
| CN110687226B (zh) * | 2019-10-18 | 2022-10-25 | 上海明捷医药科技有限公司 | 一种测定碘帕醇中2-氯丙酸含量的方法 |
| CN118414325A (zh) | 2021-12-20 | 2024-07-30 | 伯拉考成像股份公司 | 制备2,4,6-三碘间苯二甲酸双酰胺的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH608189A5 (it) * | 1974-12-13 | 1978-12-29 | Savac Ag | |
| DE2628517C2 (de) * | 1976-06-23 | 1985-02-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel |
| DE2928417A1 (de) * | 1979-07-12 | 1981-01-29 | Schering Ag | Trijodierte basen |
| IT1256163B (it) * | 1992-10-27 | 1995-11-29 | Zambon Spa | Processo per la preparazione di un intermedio della sintesi organica |
| IT1283319B1 (it) * | 1996-03-29 | 1998-04-16 | Zambon Spa | Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati |
| IT1288114B1 (it) * | 1996-06-13 | 1998-09-10 | Fructamine Spa | Processo per la purificazione di un intermedio |
-
1998
- 1998-05-08 IT IT98MI001005A patent/IT1299202B1/it active IP Right Grant
-
1999
- 1999-04-26 WO PCT/EP1999/002804 patent/WO1999058494A2/en active IP Right Grant
- 1999-04-26 DE DE69909078T patent/DE69909078T2/de not_active Expired - Lifetime
- 1999-04-26 PT PT99924824T patent/PT1075462E/pt unknown
- 1999-04-26 EP EP19990924824 patent/EP1075462B1/en not_active Expired - Lifetime
- 1999-04-26 CZ CZ20004124A patent/CZ293801B6/cs not_active IP Right Cessation
- 1999-04-26 KR KR1020007012448A patent/KR100612480B1/ko not_active Expired - Lifetime
- 1999-04-26 CN CNB998059226A patent/CN100336800C/zh not_active Expired - Lifetime
- 1999-04-26 CA CA002331660A patent/CA2331660C/en not_active Expired - Lifetime
- 1999-04-26 ES ES99924824T patent/ES2201719T3/es not_active Expired - Lifetime
- 1999-04-26 AT AT99924824T patent/ATE243676T1/de active
- 1999-04-26 DK DK99924824T patent/DK1075462T3/da active
- 1999-04-26 AU AU41356/99A patent/AU749785B2/en not_active Expired
- 1999-04-26 JP JP2000548298A patent/JP4390389B2/ja not_active Expired - Lifetime
-
2000
- 2000-11-07 NO NO20005616A patent/NO326203B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN100336800C (zh) | 2007-09-12 |
| CA2331660A1 (en) | 1999-11-18 |
| NO326203B1 (no) | 2008-10-20 |
| JP2002517381A (ja) | 2002-06-18 |
| ITMI981005A1 (it) | 1999-11-08 |
| DE69909078D1 (de) | 2003-07-31 |
| ATE243676T1 (de) | 2003-07-15 |
| AU749785B2 (en) | 2002-07-04 |
| CN1302288A (zh) | 2001-07-04 |
| NO20005616L (no) | 2000-11-07 |
| WO1999058494A3 (en) | 2000-01-20 |
| KR20010071221A (ko) | 2001-07-28 |
| WO1999058494A2 (en) | 1999-11-18 |
| EP1075462A2 (en) | 2001-02-14 |
| EP1075462B1 (en) | 2003-06-25 |
| PT1075462E (pt) | 2003-10-31 |
| AU4135699A (en) | 1999-11-29 |
| NO20005616D0 (no) | 2000-11-07 |
| CA2331660C (en) | 2008-07-08 |
| DK1075462T3 (da) | 2003-10-13 |
| ES2201719T3 (es) | 2004-03-16 |
| JP4390389B2 (ja) | 2009-12-24 |
| KR100612480B1 (ko) | 2006-08-16 |
| CZ20004124A3 (cs) | 2002-03-13 |
| CZ293801B6 (cs) | 2004-08-18 |
| DE69909078T2 (de) | 2003-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |