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ITRM950343A0 - Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal virus dell'epatite c (hcv). - Google Patents

Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal virus dell'epatite c (hcv).

Info

Publication number
ITRM950343A0
ITRM950343A0 ITRM950343A ITRM950343A ITRM950343A0 IT RM950343 A0 ITRM950343 A0 IT RM950343A0 IT RM950343 A ITRM950343 A IT RM950343A IT RM950343 A ITRM950343 A IT RM950343A IT RM950343 A0 ITRM950343 A0 IT RM950343A0
Authority
IT
Italy
Prior art keywords
hcv
hepatitis
methodology
reproduce
virus
Prior art date
Application number
ITRM950343A
Other languages
English (en)
Inventor
Licia Tomei
Raffaele De Francesco
Sven-Erik Behrens
Original Assignee
Angeletti P Ist Richerche Bio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11403393&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ITRM950343(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Angeletti P Ist Richerche Bio filed Critical Angeletti P Ist Richerche Bio
Priority to IT95RM000343A priority Critical patent/IT1278077B1/it
Publication of ITRM950343A0 publication Critical patent/ITRM950343A0/it
Priority to DK96916289T priority patent/DK0842276T3/da
Priority to JP53554696A priority patent/JP3187432B2/ja
Priority to CA002220873A priority patent/CA2220873C/en
Priority to BR9609178A priority patent/BR9609178A/pt
Priority to US08/952,981 priority patent/US6383768B1/en
Priority to PCT/IT1996/000106 priority patent/WO1996037619A1/en
Priority to AT96916289T priority patent/ATE258227T1/de
Priority to ES96916289T priority patent/ES2211956T3/es
Priority to AU59098/96A priority patent/AU708431B2/en
Priority to EP96916289A priority patent/EP0842276B1/en
Priority to DE69631375T priority patent/DE69631375T2/de
Priority to PT96916289T priority patent/PT842276E/pt
Publication of ITRM950343A1 publication Critical patent/ITRM950343A1/it
Publication of IT1278077B1 publication Critical patent/IT1278077B1/it
Application granted granted Critical
Priority to US10/085,476 priority patent/US7399605B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/127—RNA-directed RNA polymerase (2.7.7.48), i.e. RNA replicase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT95RM000343A 1995-05-25 1995-05-25 Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal IT1278077B1 (it)

Priority Applications (14)

Application Number Priority Date Filing Date Title
IT95RM000343A IT1278077B1 (it) 1995-05-25 1995-05-25 Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal
PT96916289T PT842276E (pt) 1995-05-25 1996-05-24 Metodo para a reproducao in vitro das actividades de rna polimerase dependente de rna e nucleotidil-transferase terminal codificadas pelo virus da hepatite c (hcv)
AT96916289T ATE258227T1 (de) 1995-05-25 1996-05-24 Methode zur in vitro reproduktion der rna- abhängigen rna polymerase- und terminalen nukleotidyltransferase-aktivität des hepatitis c virus (hcv)
ES96916289T ES2211956T3 (es) 1995-05-25 1996-05-24 Procedimiento para reproducir in vitro la actividad rna polimerasa dependiente de rna y la de la transferasa nucleotidil terminal que codifican el virus de la hepatitis c (hcv).
CA002220873A CA2220873C (en) 1995-05-25 1996-05-24 Method for reproducing in vitro the rna-dependent rna polymerase and terminal nucleotidyl transferase activities encoded by hepatitis c virus (hcv)
BR9609178A BR9609178A (pt) 1995-05-25 1996-05-24 Processo para reproduzir in vitro a atividade de rna-polimerase dependente de rna ou a atividade terminal-nucleotidil-transferase codificadas pelo vírus da hepatite c composição de material e uso de composições de material
US08/952,981 US6383768B1 (en) 1995-05-25 1996-05-24 Method for producing in vitro the RNA-dependent RNA polymerase and terminal nucleotidyl transferase activities encoded by hepatitis C virus (HCV)
PCT/IT1996/000106 WO1996037619A1 (en) 1995-05-25 1996-05-24 Method for reproducing in vitro the rna-dependent rna polymerase and terminal nucleotidyl transferase activities encoded by hepatitis c virus (hcv)
DK96916289T DK0842276T3 (da) 1995-05-25 1996-05-24 Fremgangsmåde til reetablering in vitro af RNA-afhængig RNA-polymerase- og terminal nukleotidyltransferase-aktiviteter
JP53554696A JP3187432B2 (ja) 1995-05-25 1996-05-24 Ｃ型肝炎ウイルス（ｈｃｖ）によってコードされるｒｎａ依存性ｒｎａポリメラーゼおよび末端ヌクレオチジルトランスフェラーゼ活性のイン・ビトロでの再生法
AU59098/96A AU708431B2 (en) 1995-05-25 1996-05-24 Method for reproducing in vitro the RNA-dependent RNA polymerase and terminal nucleotidyl transferase activities encoded by hepatitis C virus (HCV)
EP96916289A EP0842276B1 (en) 1995-05-25 1996-05-24 Method for reproducing in vitro the rna-dependent rna polymerase and terminal nucleotidyl transferase activities encoded by hepatitis c virus (hcv)
DE69631375T DE69631375T2 (de) 1995-05-25 1996-05-24 Methode zur in vitro reproduktion der rna-abhängigen rna polymerase- und terminalen nukleotidyltransferase-aktivität des hepatitis c virus (hcv)
US10/085,476 US7399605B2 (en) 1995-05-25 2002-02-27 Method for identifying a HCV RNA-dependent RNA polymerase inhibitor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95RM000343A IT1278077B1 (it) 1995-05-25 1995-05-25 Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal

Publications (3)

Publication Number Publication Date
ITRM950343A0 true ITRM950343A0 (it) 1995-05-25
ITRM950343A1 ITRM950343A1 (it) 1996-11-25
IT1278077B1 IT1278077B1 (it) 1997-11-17

Family

ID=11403393

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95RM000343A IT1278077B1 (it) 1995-05-25 1995-05-25 Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal

Country Status (13)

Country Link
US (2) US6383768B1 (it)
EP (1) EP0842276B1 (it)
JP (1) JP3187432B2 (it)
AT (1) ATE258227T1 (it)
AU (1) AU708431B2 (it)
BR (1) BR9609178A (it)
CA (1) CA2220873C (it)
DE (1) DE69631375T2 (it)
DK (1) DK0842276T3 (it)
ES (1) ES2211956T3 (it)
IT (1) IT1278077B1 (it)
PT (1) PT842276E (it)
WO (1) WO1996037619A1 (it)

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* Cited by examiner, † Cited by third party
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IT1278077B1 (it) * 1995-05-25 1997-11-17 Angeletti P Ist Richerche Bio Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal
US6461845B1 (en) * 1995-09-27 2002-10-08 Emory University Recombinant hepatitis C virus RNA replicase
CA2233309A1 (en) * 1995-09-27 1997-04-03 Emory University Recombinant hepatitis c virus rna replicase
AU1905399A (en) 1997-12-11 1999-06-28 Smithkline Beecham Corporation Hepatitis c virus ns5b truncated protein and methods thereof to identify antiviral compounds
WO1999051781A1 (en) * 1998-04-02 1999-10-14 Viropharma Incorporated Hepatitis c virus ns5b compositions and methods of use thereof
AU4393399A (en) 1998-06-24 2000-01-10 Chugai Seiyaku Kabushiki Kaisha Hcv-derived rna polymerase gene
WO2000033635A2 (en) * 1998-12-10 2000-06-15 Eli Lilly And Company Primer-independent rna synthesis catalyzed by hcv polymerase
US6297005B1 (en) 1999-05-04 2001-10-02 Schering Corporation De novo priming activity of hepatitis C virus replicase
JP2003514562A (ja) * 1999-11-23 2003-04-22 バイロファーマ・インコーポレイテッド ポリメラーゼ組成物およびその使用方法
AU764095B2 (en) * 2000-04-07 2003-08-07 Shionogi & Co., Ltd. Preincubation assay method
KR20020010241A (ko) * 2000-07-28 2002-02-04 허영섭 Ｃ형 간염 바이러스 ｒｎａ-의존성 ｒｎａ 중합효소의대량 발현 기구 및 이로부터 발현된 융합단백질을 이용한효소활성 분석방법
CA2434845C (en) 2001-01-23 2013-11-19 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Hepatitis c virus replicons and replicon enhanced cells
WO2003031588A2 (en) 2001-10-11 2003-04-17 Merck & Co., Inc. Hepatitis c virus vaccine
EP2172552A3 (en) 2001-10-11 2010-07-21 Merck Sharp & Dohme Corp. Recombinant nucleic acids comprising regions of AD6
CA2481171A1 (en) 2002-04-16 2003-10-30 Merck & Co., Inc. Hepatitis c virus assay systems
TW200400963A (en) 2002-05-21 2004-01-16 Wyeth Corp R-enantiomers of pyranoindole derivatives and the use thereof for the treatment of hepatitis C virus infection or disease
TW200400818A (en) 2002-05-21 2004-01-16 Wyeth Corp Method for the use of pyranoindole derivatives to treat infection with hepatitis C virus
US20040142322A1 (en) * 2002-10-07 2004-07-22 Schering Corporation Continuous non-radioactive polymerase assay
WO2004091724A1 (en) * 2002-10-08 2004-10-28 Wyeth Anthranilic acid derivatives useful in treating infection with hepatitis c virus
WO2004074507A2 (en) 2003-02-13 2004-09-02 Merck & Co. Inc. Method to confer cell culture replication activity to different hepatitis c virus isolates
WO2005047463A2 (en) 2003-11-05 2005-05-26 Merck & Co., Inc. Hcv replicons containing ns5b from genotype 2b
EP1711516A4 (en) 2004-01-09 2009-12-30 Merck & Co Inc RNA POLYMERASE DEPENDENT OF HCV RNA
CA2560699A1 (en) * 2004-03-24 2005-10-13 Achillion Pharmaceuticals, Inc. Quantitative assay for detection of newly synthesized rna in a cell-free system and identification of rna synthesis inhibitors
RU2007119562A (ru) 2004-10-26 2008-12-10 Институто Ди Ричерке Ди Биолоджиа Молеколаре П Анджелетти Спа (It) Тетрациклические производные индолов в качестве противовирусных агентов
WO2006110762A2 (en) * 2005-04-11 2006-10-19 Achillion Pharmaceutical compositions for and methods of inhibiting hcv replication
GB0608928D0 (en) 2006-05-08 2006-06-14 Angeletti P Ist Richerche Bio Therapeutic agents
US20090203008A1 (en) 2006-06-08 2009-08-13 Ludmerer Steven W Rapid method to determine inhibitor sensitivity of NS3/4A protease sequences cloned from clinical samples
GB0625349D0 (en) 2006-12-20 2007-01-31 Angeletti P Ist Richerche Bio Therapeutic compounds
GB0625345D0 (en) 2006-12-20 2007-01-31 Angeletti P Ist Richerche Bio Therapeutic compounds
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WO2008082484A1 (en) 2006-12-22 2008-07-10 Schering Corporation 4,5-ring annulated indole derivatives for treating or preventing of hcv and related viral infections
CN101611002A (zh) 2006-12-22 2009-12-23 先灵公司 用于治疗或预防hcv和相关病毒感染的4,5-环化吲哚衍生物
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EP2178886A1 (en) 2007-07-17 2010-04-28 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Macrocyclic indole derivatives for the treatment of hepatitis c infections
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US8377928B2 (en) 2007-11-16 2013-02-19 Merck Sharp & Dohme Corp. 3-aminosulfonyl substituted indole derivatives and methods of use thereof
EP2303893B1 (en) 2008-06-13 2016-12-07 Merck Sharp & Dohme Corp. Tricyclic indole derivatives
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WO2010082050A1 (en) 2009-01-16 2010-07-22 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Macrocyclic and 7-aminoalkyl-substituted benzoxazocines for treatment of hepatitis c infections
GB0906026D0 (en) 2009-04-07 2009-05-20 Angeletti P Ist Richerche Bio Therapeutic compounds
CN102686599B (zh) 2009-09-29 2016-10-05 杨森产品有限公司 核苷的氨基磷酸酯衍生物
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EP0464287A1 (en) * 1990-06-25 1992-01-08 The Research Foundation for Microbial Diseases of Osaka University Non-A, non-B hepatitis virus genomic cDNA and antigen polypeptide
FI913068A7 (fi) * 1990-06-25 1991-12-26 The Res Foundation For Microbial Ei-A-, ei-B-hepatiittiviruspartikkelit
US5360714A (en) * 1992-08-28 1994-11-01 Fox Chase Cancer Center Hepadnavirus polymerase gene product having RNA-dependent DNA priming and reverse transcriptase activities and methods of measuring the activities thereof
IT1272179B (it) * 1994-02-23 1997-06-16 Angeletti P Ist Richerche Bio Metodologia per riprodurre in vitro l'attivita' proteolitica della proteasi ns3 del virus hcv.
IT1278077B1 (it) * 1995-05-25 1997-11-17 Angeletti P Ist Richerche Bio Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal
CA2233309A1 (en) 1995-09-27 1997-04-03 Emory University Recombinant hepatitis c virus rna replicase

Also Published As

Publication number Publication date
CA2220873A1 (en) 1996-11-28
DE69631375D1 (de) 2004-02-26
ITRM950343A1 (it) 1996-11-25
EP0842276B1 (en) 2004-01-21
DK0842276T3 (da) 2004-05-03
BR9609178A (pt) 1999-05-04
WO1996037619A1 (en) 1996-11-28
US7399605B2 (en) 2008-07-15
ATE258227T1 (de) 2004-02-15
US6383768B1 (en) 2002-05-07
ES2211956T3 (es) 2004-07-16
DE69631375T2 (de) 2004-11-04
CA2220873C (en) 2000-10-24
AU5909896A (en) 1996-12-11
US20020164722A1 (en) 2002-11-07
IT1278077B1 (it) 1997-11-17
EP0842276A1 (en) 1998-05-20
JP3187432B2 (ja) 2001-07-11
JPH10507370A (ja) 1998-07-21
AU708431B2 (en) 1999-08-05
PT842276E (pt) 2004-05-31

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