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JOP20210142A1 - Rnai constructs for inhibiting pnpla3 expression - Google Patents

Rnai constructs for inhibiting pnpla3 expression

Info

Publication number
JOP20210142A1
JOP20210142A1 JOP/2021/0142A JOP20210142A JOP20210142A1 JO P20210142 A1 JOP20210142 A1 JO P20210142A1 JO P20210142 A JOP20210142 A JO P20210142A JO P20210142 A1 JOP20210142 A1 JO P20210142A1
Authority
JO
Jordan
Prior art keywords
rnai constructs
pnpla3 expression
inhibiting pnpla3
inhibiting
liver disease
Prior art date
Application number
JOP/2021/0142A
Other languages
Arabic (ar)
Inventor
Michael Ollmann
Ingrid Rulifson
Justin K Murray
Oliver Homann
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of JOP20210142A1 publication Critical patent/JOP20210142A1/en

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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Abstract

The present invention relates to RNAi constructs for reducing expression of the PNPLA3 gene. Methods of using such RNAi constructs to treat or prevent liver disease, nonalcoholic fatty liver disease (NAFLD) are also described.
JOP/2021/0142A 2018-12-10 2019-12-10 Rnai constructs for inhibiting pnpla3 expression JOP20210142A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862777714P 2018-12-10 2018-12-10
PCT/US2019/065481 WO2020123508A2 (en) 2018-12-10 2019-12-10 Rnai constructs for inhibiting pnpla3 expression and methods of use thereof

Publications (1)

Publication Number Publication Date
JOP20210142A1 true JOP20210142A1 (en) 2023-01-30

Family

ID=69024749

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2021/0142A JOP20210142A1 (en) 2018-12-10 2019-12-10 Rnai constructs for inhibiting pnpla3 expression

Country Status (23)

Country Link
US (1) US20220017906A1 (en)
EP (1) EP3894555A2 (en)
JP (2) JP2022511550A (en)
KR (1) KR20210102932A (en)
CN (1) CN113166761B (en)
AR (1) AR117297A1 (en)
AU (1) AU2019396419A1 (en)
BR (1) BR112021011061A2 (en)
CA (1) CA3121510A1 (en)
CL (1) CL2021001489A1 (en)
CO (1) CO2021008997A2 (en)
CR (1) CR20210371A (en)
EA (1) EA202191629A1 (en)
IL (1) IL283473A (en)
JO (1) JOP20210142A1 (en)
MX (1) MX2021006784A (en)
NZ (1) NZ776661A (en)
PE (1) PE20211225A1 (en)
PH (1) PH12021551326A1 (en)
SG (1) SG11202105711SA (en)
TW (1) TW202039843A (en)
UY (1) UY38503A (en)
WO (1) WO2020123508A2 (en)

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EA202191629A1 (en) 2021-09-03
CR20210371A (en) 2021-08-27
CO2021008997A2 (en) 2021-07-30
SG11202105711SA (en) 2021-06-29
BR112021011061A2 (en) 2021-08-31
CN113166761A (en) 2021-07-23
TW202039843A (en) 2020-11-01
PE20211225A1 (en) 2021-07-06
WO2020123508A2 (en) 2020-06-18
MX2021006784A (en) 2021-07-15
AR117297A1 (en) 2021-07-28
PH12021551326A1 (en) 2022-04-25
AU2019396419A1 (en) 2021-06-17
WO2020123508A3 (en) 2020-08-13
KR20210102932A (en) 2021-08-20
NZ776661A (en) 2025-07-25
US20220017906A1 (en) 2022-01-20
UY38503A (en) 2020-06-30
EP3894555A2 (en) 2021-10-20
CN113166761B (en) 2025-09-09
IL283473A (en) 2021-07-29
CL2021001489A1 (en) 2022-01-07
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JP2022511550A (en) 2022-01-31
CA3121510A1 (en) 2020-06-18

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