JP2000063227A - Agent for stimulating degradation of lipid and skin preparation for external use and for slimming body - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a lipid degradation-stimulating agent having an excellent lipid degradation-stimulating action, and to provide a body-slimming skin preparation for external use. SOLUTION: This lipid degradation-stimulating agent contains the extract of two or more kinds of galenicals selected from Prunus armeniaca, Paeonia albiflora, Prunus persica, Pachyma hoelen, Platycodon grandiflorum, Schizonepeta tenuifolia, cinnamon bark, Polyporus umbellatus, Atractylodis rhizoma, rehmanniae radix, rhizome of Cnidium officinale, zizyphi fructus, angericae radix, ophiopogon tuber, Mentha herb, Alisma rhizome, saposhnikovia root and Corni fructus.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a lipolysis promoter having an excellent lipolysis-promoting action, and a slimming skin external preparation using the lipolysis-promoter.

[0002]

2. Description of the Related Art In the past, in order to reduce excess fat on the face and body and maintain a lean body, in addition to various exercises and dietary restrictions, massage for promoting metabolism in the body It is known to use cosmetics such as gel and cream. Such cosmetics include
A lipolysis-promoting agent such as caffeine has been added for the purpose of promoting the lipolysis of fat cells constituting fat and having a slimming effect. In addition to caffeine as a substance that promotes lipolysis, as a plant extract, tea extract,
Although kola extract and the like are known, none of them have sufficient effects, and there has been a demand for the development of a more effective lipid decomposition promoting substance.

Therefore, an object of the present invention is to provide a lipolysis promoter which promotes lipolysis of adipocytes and gives an excellent slimming effect.

[0004]

[Means for Solving the Problems] The inventors of the present invention have conducted extensive studies as to whether or not there is a substance that promotes lipolysis of adipocytes, and as a result, kyounin, peony, tonin, bukuro,
Effectiveness of extracts from one or more of kyokyou, keikai, keishi, chorei, juniper, zelkova, zelkova, pearl millet, touki, bakumondou, mint, takusha, boufu and sanshuyu, and this It has been found that a combination of the extract and other specific components further enhances the lipolysis promoting effect and the use effect, and has completed the present invention.

That is, the present invention relates to one or two kinds of Kyounin, Peonies, Tounin, Bukuryou, Kyoukyo, Keikai, Keishi, Chorei, Jakujutsu, Jio, Senkyu, Taiso, Touki, Bakumondou, Hakka, Takusha, Boufu and Sanshuyu. A lipid decomposition promoter comprising the extract extracted as described above, and a slimming skin external preparation containing the extract as an active ingredient.

Further, according to the present invention, Kyounin, peony, Tounin, Bukyou, Kyoukyo, Keikai, Keishi, Chorei, juniper, zelkova, senkyu,
Taiso, Touki, Bakumondou, peppermint, Takusha,
There is provided a slimming skin external preparation, which comprises an extract extracted from one or more of Bofu and Sanshuyu as an active ingredient and other specific ingredients.

The structure of the present invention will be described in detail below. The plant extract used in the present invention includes flowers, stems, fruits, seeds,
Roots, whole plants, etc. are used. The extraction method is not particularly limited, for example, water, a hydrophilic organic solvent such as alcohol, or a mixed solution thereof, or glycerin, 1,
It is extracted with a polyhydric alcohol such as 3-butylene glycol or a mixed liquid of water and a polyhydric alcohol.

The content of the extract in the external preparation for skin is 0.001 to 30.0% by weight, preferably 0.01 to 20.0% by weight in terms of dry matter. If the content of the extract is less than 0.001% by weight, a sufficient lipolytic effect cannot be obtained.

[0009] In the present invention, one or two kinds of Kyounin, peony, Tounin, Bukyou, Kyoukyo, Keikai, Keishi, Chorei, juniper, zelkova, diorama, senkyu, tanso, touki, bakumondou, mentha, takusha, bofu and sanshuyu. The combined use of the extract extracted from the above and other specific components further enhances the lipolysis promoting effect.

Examples of the specific component include xanthine derivatives, Lavandula genus plant extracts, Apiaceae fennel plant extracts, inosit, dextran sulfate, seaweed extracts, amino acids, escrosides, citrus plant extracts, β-adrenergic stimulant, α2-adrenergic inhibitor, bipyridine derivative, pepper extract, thistle plant extract, tea extract, Coptis chinensis extract, Oataku extract, berberine-type alkaloid, Ginkgo biloba extract, Ginseng extract, Primrose extract, Centella asiatica extract, Butcher bloom extract, Mallow extract, Turmeric extract, Thyme extract, Arnica extract, Ginkgo extract, Horse chestnut extract, Capsicum extract, Ivy extract, Mannen wax, Calendula, Salvia, Hypericum perforatum. , Astragalus extract, Ginger, Rosemary extract, Anethole, Saponins,
One or more selected from horse mackerel extract, clematis extract and plant extract of Amaranthaceae are preferable.

Examples of the xanthine derivative used in the present invention include xanthine, aminophylline, theophylline, choline theophylline, caffeine, theobromine, 1,7-dimethylxanthine, oxtrifine,
Examples include diprophylline and proxyphylline. These may be used alone or in combination of two or more. These xanthine derivatives may be synthetic or substantially isolated from plants such as tea leaves.

The plant of the genus Lauandra, used in the present invention, contains about 20 kinds of plants, for example, Lauandra,
Angustifolia, Lavender, Rauandra
Examples include Angustifolia Pyreneika, Spike Lavender, and Lavandin. These plants are
Flowers, stems, fruits, seeds, roots, whole plants and the like are used, and flowers are preferably used. The extraction method is not particularly limited, for example, water, a hydrophilic organic solvent such as alcohol, or a mixed solution thereof, or glycerin, a polyhydric alcohol such as 1,3-butylene glycol, or water and a polyhydric alcohol. It is extracted with a mixed solution of.

The plant of the genus Apiaceae used in the present invention includes 2-3 species, and examples thereof include fennel and Italian fennel. As these plants, flowers, stems, fruits, seeds, roots, whole plants and the like are used, and fruits are preferably used. The extraction method is not particularly limited, for example, water, a hydrophilic organic solvent such as alcohol, or a mixed solution thereof, or glycerin, a polyhydric alcohol such as 1,3-butylene glycol, or water and a polyhydric alcohol. It is extracted with a mixed solution of.

The seaweed extract used in the present invention is a brown alga,
It is extracted from all algae of red algae and green algae, and the extraction method is not particularly limited. For example, water, a hydrophilic organic solvent such as alcohol, or a mixed solution thereof, or glycerin, 1,3- It is extracted with a polyhydric alcohol such as butylene glycol or a mixed liquid of water and a polyhydric alcohol.

The Rutaceae plant used in the present invention includes the citrus genus Citrus
unshiu Marcov), Ovenimikan (C
itrus tangerina Tanaka), cobenimikan (Citrus erythrosa Ta
naka), mandarin orange (Citrus aurantiu)
m L subsp. nobilis Makin
o), Citrus aurantium L., Daidai (Citrus aurantium L., va
r. daidai Makino), Marubushkan (Citrus medica L), Natsumikan (C
itrus Natsudaidai Hayat
a), pomelo (Citrus grandis Osb)
eck), Yuzu (Citrus Junos Tana)
ka), Ponkan (Citrus reticulat)
a Blanco), lemon (Citrus limo)
n Burmann), Karatachi (Citrus tr)
ifoliata L), a Fortunella genus Malchincan (Fortunella japonica)
Swingle), Xanthoxium piperium D
C. ), The genus Evodia (Evodia r)
utaecarpa Hook. fil et Tho
ms. ), As well as Aegle m.
armelos Corr), Bukkokinoki (Agat)
hosma betulina Pill), Chinese cabbage (Dictamnus albus L), Indica Zinsho (Fragara mante churica H)
onda), European heron (Orixa japonica)
Thunb), Yellowfin (Phellodendron)
amurense Rupr, Pilocarpus penna
tifolius Lan), Phellodendron chinens
e Schneido), Henruda (Ruta gr)
aveolens L), Miyamaximi (Skimmi)
a japonica Thunb) and the like.
Among these, Obeni mandarin and Coben mandarin are especially preferable.

The citrus plants are mature,
Or immature fruits, peels, seeds, leaves, petioles, branches, roots,
Flowers and the like are used as a raw material, and among them, fruits, peels and leaves are preferable. However, among the above Rutaceae plants, there are Chenpi and orange peel (spruce) that are used for internal use or for external use / bath, which are distributed in Kampo prescription for the purpose of stomach ache, antitussive and carminative. . The rind is mainly Citrus unshiu Marcov,
The orange peel is Citrus aurantium L. or Daidai (Citrus aurantium L., v
ar. It is a matured pericarp of daidaii Makino), and when these are used as a raw material, the effect intended by the present invention is small. Therefore, it is preferable to use immature fruits or leaves for these three species. In addition, mandarin oranges (Citrus aurantium) that have been eaten conventionally
L subsp. nobilis Makino, Citrus Natsudaidai H
ayata), pomelo (Citrus grandis
Osbeck, Yuzu (Citrus Junos)
Tanaka, lemon (Citrus limon)
Burmann) mature pulp and salmon (X
anthoxium piperium DC. With respect to the matured fruit of (1), since the effect of the present invention is small, it is preferable to use an immature fruit, or a pericarp or leaf.

The Rutaceae plant of the present invention is used as a water-soluble solvent extract. Examples of the solvent extract include water or lower alcohols, those extracted with an organic solvent such as polyol or a mixed solvent thereof,
This is conveniently used after being subjected to concentration, purification, sterilization, drying, etc. as appropriate.

The β-adrenergic stimulant used in the present invention is not particularly limited, and examples thereof include isoproterenol, epinephrine, norepinephrine, dobutamine, dopamine, butopamine, salbutamol, terbutaline, isoethalin, protoxylol, fenoterol, metaproterenol, Chlorprenaline, hexoprenaline, trimethoquinol, procaterol hydrochloride, prenalterol, forskolin, disodium (R, R) -5- [2
-[[2- (3-Chlorophenyl) -2-hydroxyethyl] -amino] propyl] -1,3-benzodioxole-2,2-dicarboxylate, (R, R) -4-
[2-({2-[(3-chlorophenyl) -2-hydroxyethyl] amino} propyl) phenyl] phenoxyacetic acid, {2-hydroxy-5- [2-({2-hydroxy-3- [4- ( 1-methyl-4-trifluoromethyl) -1H-imidazol-2-yl] phenoxy} propyl) amino] ethoxy} -benzamide monomethanesulfonate, erythro-DL-1- (7-methylindan-4-yloxy) ) -3-Isopropylaminobutan-2-ol and pharmacologically acceptable salts thereof. Examples of the pharmaceutically acceptable salt include pharmaceutically acceptable acid addition salts, metal salts, ammonium salts, organic amine addition salts, amino acid addition salts and the like. In the present invention, it is preferable to use one or more selected from the group consisting of isoproterenol, dobutamine, salbutamol and pharmacologically acceptable salts thereof. As the salt in this case, hydrochloride or sulfate is used. Is preferred.

The α2 adrenergic action inhibitor used in the present invention is not particularly limited and includes, for example, yohimbine, phentolamine, phenoxybenzamine, trazoline, ergotamine, ergotoxin, dihydroergotamine, ergomethrin, methylergomethrin, dihydroergotoxin, lauorcin, Examples thereof include piperoxane and pharmacologically acceptable salts thereof. Examples of the pharmacologically acceptable salt include those similar to the above. In the present invention, it is preferable to use one or more selected from the group consisting of yohimbine, phentolamine, ergotamine and pharmaceutically acceptable salts thereof, and as the salt in this case, a mesylate salt or a tartrate salt, The hydrochloride salt is preferred.

The bipyridine derivative used in the present invention includes amrinone, milrinone, 5-cyano- [3,
4′-bipyridin] -6 (1H) -one, 5-carbamyl- [3,4′-bipyridin] -6 (1H) -one, and pharmacologically acceptable salts of these.

Pepperaceae plants used in the present invention include pepper (Piper nigrum L.), hihatsu (Piper longum L.), and Sadasou (Peperomia japonica Makin).
o), sesame show (PePeromia bunin)
siemesis Makino), Peperomia caperata Ru
iz. et Pav. ), Japanese armyworm (PePe
romia incana A. Dietr), P. perennia magnolif
olia A. Dietr. var varyegat
a R.A. et P. et al. ), Chinese mackerel (Pepper)
omia puteolata Trel. ), Peaomia sandersii
C. DC. var. argyrea Baile
y), betel (Pipere betele L.), cubbeba (Piper cubebe L.), hippo (Pi)
per mesosticum Forst, Javan Goatfish (Piper retrofructu)
m Vahl), Nantogogosho (Piper au)
rantiacum Wall. var hupehen
se C. DC. ), Amberjack, Piper k
Adzura Ohwi), Piper Boehmérief Wall
olium Wall), Piper Hainanese Hemml,
Pippa Hausie Maxim. (Piper hauce
i Maxim. ), And pipermentomentum Roxb. Among these, yosho and hihatsu are particularly preferable.

Such pepper plants include mature or immature fruits, peels, seeds, leaves, petioles, branches,
Roots, flowers, etc. are used as raw materials, but among them, fruits,
Peel and leaves are preferred. However, among the above-mentioned pepper plants, pepper (Piper nigrum L.) is widely used as a spice and is known to have sweating and stomachic action, but those used for food use immature fruits. It is called dried black pepper or white pepper that has been dried by removing the outer skin of the mature fruit. On the other hand, when it is used for the purpose of the present invention, it is preferable to use a green fruit which is more immature than the immature fruit used for black pepper.

The pepper plant of the present invention is used as a water-soluble solvent extract. Examples of the solvent extract include those extracted with water or an organic solvent such as a lower alcohol or a polyol, or a mixed solvent thereof, which is used after being appropriately concentrated, purified, sterilized, dried and the like.

The plants of thistle family used in the present invention include Cephalon which belongs to the genus Alethisia.
oplos segmentum (Bieb.) Kita
m. ), Ezo fox thistle (Cephalonopl
os setosum (Bieb.) Kitam. );
Cirsium purpur
atum (Maxim.) Matsum. ), Thistle (Cirsium pendulum Fische)
r), thistle (Cirsium ugoense)
Nakai), Aruba hire thistle (Cirsium g)
rayanum (Maxim.) Nakai), thistle (Cirsium kamtschaticum)
Ledeb. ), Thistle (Cirsium s)
ieboldii Miq. ), Teriha Thistle (Cir
sium lucens Kitam. ), Cirsium yezoense (Maxim.)
Makino), Thistle Beetle (Cirsium)
tenuisquamatum Kitam. ), Yellow thistle (Cirsium tashiroi Kit)
am. ), Thistle (Cirsium hidaen)
se Kitam. ), Thistle (Cirsiu)
m spinosum Kitam. ), Thistle (Cirsium maritimum Makin)
o), thistle (Cirsium brevicau)
le A. Gray), Greater thistle (Cirsi)
um boninense Koidz. ), Thistle (Cirsium japonicum DC.), And coral thistle (Cirsium japonicum D)
C. var australe Kitam. ), White thistle (Cirsium Joponic)
um DC. vartakaoense Kita
m. ), Nora Thistle (Cirsium oligop)
hyllum (Franch. et Savat.) M
atsum. ), Thistle (Cirsium)
chokaiense Kitam. ), Cirsium borealininipponens
e Kitam. ), Dwarf Milk Thistle (Cir
sium okamotoi Kitam. ), Murakumo thistle (Cirsium maruyama manum)
Kitam. ), Water thistle (Cirsium)
diabolicum Kitam. ), Rice Cirrus (Cirsium magofukui Kita)
m. ), Yanagia thistle (Cirsium linear)
e (Thunb.) SchBip. ), Mori thistle (C
irsium dipsacorepis (Maxi
m. ) Matsum. ), Thistle (Cirsiu)
m kagamontanum Nakai), Suzuki thistle (Cirsium suzukii Kita)
m. ), Gold thistle (Cirsium gyoj)
anum Kitam. ), Koibu thistle (Cirs
ium confertissimum Nakai),
Thistle (Cirsium bitchuen)
se Nakai), Eyes thistle (Cirsiu)
m aidzuense Nakai), thistle (Cirsium buevgeri Mix), Nagano thistle (Cirsium longepedun)
curatum Kitam. ), Thistle thistle (C
irsium heianium Koidz. ), Thistle (Cirsium suzukiense)
Kitam. ), White veil thistle (Cirsi
um furusei Kitam. ), White thistle (Cirsium effusum (Maxim.)
Matsum. ), Hit thistle (Cirsium)
congestissimum Kitam. ), Thistle (Cirsium spicatum (Maxi
m. ) Matsum. ), Thistle (Cirsiu)
m tenue Kitam. ), Azumayama thistle (Cirsium microspicatum Na
kai), thistle (Cirsium inunda)
tum Makino), Norikura Thistle (Cirsi)
um norikurense Nakai, Cirsium amplififolia
um Kitam. ), Chinese thistle (Cirsiu)
m matsumurae Nakai, Cirsium ganjuense Kita
m. ), Thistle (Cirsium baban)
um Koidz. var otayae (Kita
m. )), Cirsicum suffu
ltum (Maxim.) Matsum. ), Thistle (Cirsium nipponicum (Max
im. ) Makino), Yakushima thistle (Cirsi)
umyakushimense Masam. ), Thistle (Cirsium chikushiense K)
oidz. ), Thistle (Cirsium han)
amakise Kitam. ); Cardiac crispus L. of the genus Cirea;
Saussurea p
ulcheila Fisher, Saussurea japonica (Thun
b. ) DC. ), Yukiba Higotai (Saussurea)
Chionophylla Takeda), white thistle (Saussurea nikoensis F)
Ranch et Savat. ), Iwatehigotai (Saussurea brachycephala)
French. ), Miyama thistle (Saussur
ea franchetii Koidz. ), Saussurea yanagisa
wae Takeda), Folly thistle (Sauss)
urea faurii Franch. ), White thistle (Saussurea gracilis Ma)
xim. ), Kirishima Higotai (Saussurea)
scaposa French et Sava
t. ); Leopard thistle (Hemist)
epta lyrata Bunge); Synemus excelsus of the genus Yamabuchi
(Makino) Kitam. ), Yamabokuchi (Syn
urus palmatopinn atifidus
(Makino) Kitam. var indivis
us Kitam. ), Oyamabokuchi (Synurus)
pungens (Franch et Sava
t. ) Kitam. ); Tamurasou of the genus Tamurasou (S
erratula coronata L. Subs
p. insularis (Iljin) Kita
m. ); Ochera (Atractylodes)
japonica Koidz. exKit
m. ); Higotai (Echinops s)
etifler Iljin) and the like. Among these, those of the genus Arechia, thistle and genus Thistle are particularly preferable, and among these, arele thistle, horned fox thistle, horned thistle, mountain thistle, thistle, nora thistle, thistle, octopus thistle and leaf thistle are preferable. In addition, among these plants of the thistle family, the holly thistle and the thistle etc. have haemostasis, anti-inflammatory and diuretic action, and are known as crude drugs.

The thistle plant of the present invention can be used with leaves, head flowers, seeds, stems, roots and whole plants as raw materials, and among them, it is particularly preferable to use roots and stems.

The thistle plant in the present invention is used as a water-soluble solvent extract. Examples of the solvent extract include water or lower alcohols, those extracted with an organic solvent such as polyol or a mixed solvent thereof,
This is used after being appropriately concentrated, purified, sterilized, dried and the like.

With respect to the other extracts, the extraction method is not particularly limited, and examples thereof include hydrophilic organic solvents such as water and alcohol, mixed solutions thereof, and glycerin, 1,3-butylene glycol and the like. It is extracted with a polyhydric alcohol or a mixed liquid of water and a polyhydric alcohol. These are appropriately concentrated, purified, sterilized, dried, etc. before use.

The berberine-type alkaloid has the general formula (1):

[0029]

[Chemical 1]

(In the formula, R ¹ and R ² are the same or different and each represents an alkyl group having 1 to 5 carbon atoms, n represents an integer of 1 to 5, and X represents a monovalent anion. ), A berberine salt or a derivative thereof represented by the general formula (2):

[0031]

[Chemical 2]

(In the formula, R ¹ , R ² , R ³ and R ⁴ are the same or different and each represents an alkyl group having 1 to 5 carbon atoms;
Represents a monovalent anion. ) And a derivative thereof, and a general formula (3):

[0033]

[Chemical 3]

(In the formula, n and m each represent an integer of 1 to 5, and X represents a monovalent anion.), And a coptidine salt or a derivative thereof is preferable.

Berberine chloride represented by the general formula (1) in which R ¹ and R ² are both methyl groups, n is 1 and X is a chlorine ion, or R ^{1 to} R ⁴ are all methyl groups , X is a chlorine ion, the palmatine chloride represented by the general formula (2) is a yellow-billed Phelloden of the Rutaceae family.
dron amurense and its variants, or P
Cork-layer-excluded bark of Heldendron chinense and its variants, Barberry Berb of the family Barberry
eris thumbergii xylem, contained in the roots of Colombo Jateorhiza columba of the family Aceraceae, has a strong antibacterial action against Gram-negative bacteria such as Escherichia coli, cholera, typhoid, and is a bacterial agent as a stomach, intestine, and bactericide. It is used for diarrhea, abnormal intestinal fermentation, etc., and for poultice and eye drops for bruising.

Coptidine chloride represented by the general formula (3) in which n and m are both 1 and X is a chloride ion is a Coptis japonica of the buttercup family.
Or the Coptis japonica var. di
It is contained in the rhizome of secta, and is used as a bitter stomachic medicine, intestinal medicine, anti-inflammatory and astringent medicine for gastroenteritis, abdominal pain, jaundice, diarrhea, etc., and for poultice and eye drops for bruises.

The berberine salt or its derivative, the palmatine salt or its derivative, and the coptidine salt or its derivative may be used alone or in any two of them.
You may use it in combination of 2 or more types.

As these berberine-type alkanoids, those extracted and purified from the above plants, synthetic products, and those extracted and purified from callus cultures of Coptis chinensis can be used. Furthermore, it is also possible to use extracts such as yellowfin, colombo root, barberry, oren containing berberine chloride, palmatine chloride or coptidine chloride, or fractionated products of these extracts.

Water, methanol, ethanol, isopropyl alcohol, butanol, ethyl acetate, acetone, ether, chloroform and the like can be used as a solvent for the extraction of berberine type alkanoides. You may use these solvents in combination of 2 or more types. Of these, particularly preferable solvents are water, methanol and ethanol.

The plant of the family Amaranthaceae used in the present invention includes about 20 species or more. For example, Amaranthaceae (rhizome and / or stem is referred to as "preserved"), Aotsutsurafuji, Isoyama Aoki, Tsutsurafuji, Tamasakitsuduji, Miyakojitsuduji, Examples include Hora-itsuduraji, bats, pearl vines, vine vines, vine vines, blue vines, pearl oysters, and colombo. Among these, rhizome and / or stem (prevented) of Otsutsurafuji are particularly preferable.

These plants include flowers, stems, fruits, seeds,
Roots, whole plants, etc. are used, and preferably, rhizomes and / or stems are used for plants of the family Astragalus. The extraction method is not particularly limited, for example, water, a hydrophilic organic solvent such as alcohol, or a mixed solution thereof, or glycerin, a polyhydric alcohol such as 1,3-butylene glycol, or water and a polyhydric alcohol. It is extracted with a mixed solution of.

In the present invention, the amount of the other component (A) used in combination with the Kyounin extract in the external preparation for skin is 0.001 to 30.0% by weight in terms of dry matter, preferably 0.01. ~ 20.0% by weight.

The external preparation for skin of the present invention may contain, if necessary, various components generally used in cosmetics, pharmaceuticals and the like within a range that does not impair the effects of the present invention. Examples of such components include the following.

Vitamin oils, vitamins A such as retinol and retinol acetate, riboflavin, riboflavin butyrate,
Vitamin B2 such as flavin adenine nucleotide, pyridoxine hydrochloride, vitamin B6 such as pyridoxine dioctanoate, L-ascorbic acid, L-ascorbic acid dipalmitate, L-ascorbic acid-2
-Vitamin Cs such as sodium sulfate, L-ascorbic acid phosphate, L-ascorbic acid glucoside, DL-α-tocopherol-L-ascorbic acid diester dipotassium, calcium pantothenate, D-
Pantothenic alcohols such as pantothenyl alcohol, pantothenyl ethyl ether, acetyl pantothenyl ethyl ether, vitamin Ds such as ergocalciferol and cholecalciferol, nicotinic acid, nicotinic acid amide,
Examples thereof include nicotinic acid such as benzyl nicotinate, vitamin Es such as α-tocopherol, tocopherol acetate, DL-α-tocopherol nicotinate and DL-α-tocopherol succinate, and vitamins such as vitamin P and biotin.

The liquid oils and fats include avocado oil, camellia oil, evening primrose oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil,
Castor oil, linseed oil, safflower oil, cottonseed oil, eno oil,
Soybean oil, peanut oil, teaseed oil, kaya oil, rice bran oil, cinnamon oil, Japanese tung oil, jojoba oil, germ oil, triglycerin, glyceryl trioctanoate, glyceryl triisopalmitate, etc., are solid cacao. Fat, coconut oil, horse fat, hydrogenated coconut oil, palm oil, beef tallow, sheep fat, hydrogenated beef tallow, palm kernel oil, pork fat, beef bone fat, mokuro kernel oil, hydrogenated oil, beef tallow, mokurou, hydrogenated castor oil As waxes, beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ivota wax, whale wax, montan wax, nukarou, lanolin, capock wax, lanolin acetate, liquid lanolin, sugarcane wax, lanolin fatty acid isopropyl, hexyl laurate, reduced lanolin. , Jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, P E lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether and the like, hydrocarbon oils include liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax, etc. , As essential oils, peppermint oil, jasmine oil, camphor oil, cypress oil, spruce oil, ryu oil, turpentine oil, cinnamon oil, bergamot oil, mandarin oil, chive oil, pine oil, lavender oil, bay oil, clove oil. , Hiba oil, rose oil, eucalyptus oil, lemon oil, thyme oil, peppermint oil, rose oil, sage oil, menthol, cineole, eugenol, citral citronellal, borneol, linalool, geranio Le, camphor, thymol, spilanthol, pinene, limonene, include oil of terpene compounds.

Examples of the higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid (beheninic acid), oleic acid, 12-hydroxystearic acid, undecylenic acid, tall acid, isostearic acid, linoleic acid and linolein. Acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and the like.

Examples of higher alcohols include linear alcohols such as lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol and cetostearyl alcohol, monostearyl glycerin ether (batyl alcohol), 2-decyltetradecyl alcohol. Examples thereof include branched chain alcohols such as knoll, lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol, and octyldodecanol.

The synthetic ester oils include isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate,
Decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, 1
Cholesteryl 2-hydroxystearate, ethylene glycol di-2-ethylhexylate, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, diisostearyl malate, glycerin di-2-heptylundecanoate. Trimethylolpropane tri-2-ethylhexylate, trimethylolpropane triisostearate, penta-2-erythritol tetrahexylhexanoate, glycerin tri-2-ethylhexylate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glycerin trimyristate, tri-2-
Heptylundecanoic acid glyceride, castor oil fatty acid methyl ester, oleyl oleate, cetostearyl alcohol, acetoglyceride, 2-heptylundecyl palmitate, diisobutyl adipate, N-lauroyl-L-glutamic acid-2-octyldodecyl ester, adipic acid Di-2-heptyl undecyl, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate. , Ethyl acetate, butyl acetate, amyl acetate, triethyl citrate and the like.

Examples of the silicone include chain polysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, decamethylcyclopolysiloxane, dodecamethylcyclopolysiloxane, and tetramethyltetrahydrogencyclopolysiloxane. Cyclic polysiloxanes such as 3
Examples thereof include silicone resin and silicone rubber that form a three-dimensional network structure.

Examples of moisturizers include polyethylene glycol, propylene glycol, glycerin, 1,3-
Butylene glycol, hexylene glycol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, bile salt, dl-pyrrolidone carboxylate, Examples thereof include short-chain soluble collagen, diglycerin (EO) PO adduct, Iris yezoensis extract, Yarrow extract and Merrilot extract.

As the ultraviolet absorber, para-aminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxy PABA ethyl ester, N,
Benzoic acid type UV absorbers such as N-dimethyl PABA ethyl ester and N, N-dimethyl PABA butyl ester, anthranilic acid type UV absorbers such as homomenthyl-N-acetylanthranilate, amyl salicylate,
Salicylic acid type UV absorbers such as menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, octylcinnamate, ethyl-4-isopropylcinnamate, methyl-2,5-diisopropylcinnamate , Ethyl-2,
4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, octyl-p-methoxycinnamate (2- Ethylhexyl-p
-Methoxycinnamate), 2-ethoxyethyl-p-
Methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono-2-ethylhexanoyl-diparamethoxy Cinnamates, cinnamic acid-based UV absorbers such as 3-methyl-4- [methylbis (trimethylsiloxy) silyl] butyl 3,4,5-trimethoxycinnamate, 2,4-dihydroxybenzophenone, 2,2 '
-Dihydroxy-4-methoxybenzophenone, 2,
2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2 ', 4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n
-Benzophenone-based UV absorbers such as octoxybenzophenone and 4-hydroxy-3-carboxybenzophenone, 3- (4'-methylbenzylidene) -d, 1-camphor, 3-benzylidene-d, 1-camphor, urocanic acid, Urocanic acid ethyl ester, 2-phenyl-5-methylbenzoxazole, 2,2'-hydroxy-5-methylphenylbenzotriazole, 2- (2 '
-Hydroxy-5'-t-octylphenyl) benzotriazole, 2- (2'-hydroxy-5'-methylphenylbenzotriazole, dibenzalazine, dianisoylmethane, 4-methoxy-4'-t-butyldibenzoylmethane, 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one and the like can be mentioned.

Examples of the anionic surfactant include a base for soap, a fatty acid soap such as sodium laurate and sodium palmitate, a higher alkyl sulfate ester salt such as sodium lauryl sulfate and potassium lauryl sulfate, POE lauryl sulfate triethanolamine, and the like. PO
E Alkyl ether sulfate ester salts such as sodium lauryl sulfate, N-acyl sarcosinic acid such as sodium lauroyl sarcosine, N-myristoyl-N-methyl taurine sodium, coconut oil fatty acid methyl tauride sodium, higher fatty acids such as sodium lauryl methyl tauride Amidosulfonate, sodium phosphate ester of POE oleyl ether phosphate, POE stearyl ether phosphate, etc., sodium di-2-ethylhexyl sulfosuccinate, monolauroyl monoethanolamide sodium polyoxyethylene sulfosuccinate, lauryl polypropylene glycol sulfosuccinate Sulfosuccinates such as sodium, sodium linear dodecylbenzene sulfonate, triethanolamine linear dodecylbenzene sulfonate Alkylbenzene sulfonates such as linear dodecylbenzene sulfonic acid, N-lauroyl glutamate monosodium, N-stearoyl glutamate disodium, N-myristoyl-L-glutamate monosodium and other N-acyl glutamate, hydrogenated coconut oil fatty acid glycerin sodium sulfate Higher fatty acid ester sulfate ester salt such as, sulfated oil such as funnel oil, PO
E alkyl ether carboxylic acid, POE alkyl allyl ether carboxylate, α-olefin sulfonate,
Examples thereof include higher fatty acid ester sulfonates, secondary alcohol sulfate ester salts, higher fatty acid alkylolamide sulfate ester salts, sodium lauroyl monoethanolamide succinate, ditriethanolamine N-palmitoyl aspartate, and sodium caseinate.

Examples of the cationic surfactant include alkyl trimethyl ammonium salts such as stearyl trimethyl ammonium chloride and lauryl trimethyl ammonium chloride, distearyl dimethyl ammonium dialkyl dimethyl ammonium chloride, poly (N, N'-dimethyl-3, 5-methylene piperidinium), an alkylpyridinium salt such as cetylpyridinium chloride, an alkyl quaternary ammonium salt, an alkyldimethylbenzylammonium salt, an alkylisoquinolinium salt, a dialkylmorphonium salt, a POE alkylamine, an alkylamine salt, Examples thereof include polyamine fatty acid derivatives, amyl alcohol fatty acid derivatives, benzalkonium chloride and benzethonium chloride.

Examples of the amphoteric surfactant include 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyl ester. Imidazoline surfactants such as roxy disodium salt, 2-heptadecyl-N-carboxymethyl-N-
Examples thereof include betaine-based surfactants such as hydroxyethyl imidazolinium betaine, lauryl dimethylamino acetic acid betaine, alkyl betaine, amido betaine and sulfobetaine.

Examples of lipophilic nonionic surfactants include sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, Penta-2-ethylhexylate diglycerol sorbitan, tetra-2-ethylhexylate diglycerol sorbitan, and other sorbitan fatty acid esters, monocotton oil fatty acid glycerin, glyceryl monoerucate, glycerin sesquioleate, glyceryl monostearate, α,
α'-Glycerin oleoyl pyroglutamate, glycerin monostearate Glycerin polyglycerin fatty acids such as malic acid, propylene glycol fatty acid esters such as propylene glycol monostearate, hydrogenated castor oil derivative, glycerin alkyl ether, polyoxyethylene methyl Examples thereof include polysiloxane copolymers.

Examples of the hydrophilic nonionic surfactant include POE sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate and the like.
Sorbitan fatty acid esters, POE-sorbit monolaurate, POE-sorbit monooleate, PO
POE sorbit fatty acid esters such as E-sorbit pentaoleate and POE-sorbit monostearate, POE glycerin fatty acid esters such as POE-glycerin monostearate, POE-glycerin monoisostearate and POE-glycerin triisostearate , POE monooleate, POE distearate,
POE monodiolate, POE fatty acid esters such as ethylene glycol distearate, POE lauryl ether, POE oleyl ether, POE stearyl ether, POE behenyl ether, POE 2-octyldodecyl ether, POE alkyl ethers such as POE cholestanol ether, POE octyl POE alkyl phenyl ethers such as phenyl ether, POE nonyl phenyl ether, POE dinonyl phenyl ether, Pluronic type such as Pluronic, POE
POE / POP alkyl ethers such as POP cetyl ether, POE / POP 2-decyl tetradecyl ether, POE / POP monobutyl ether, POE / POP hydrogenated lanolin, POE / POP glycerin ether, and tetraPOE / tetraPOP ethylenediamine such as Tetronic Condensates, POE castor oil, POE hydrogenated castor oil, POE hydrogenated castor oil monoisostearate,
POE hydrogenated castor oil triisostearate, POE hydrogenated castor oil monopyroglutamic acid monoisostearate diester, POE hydrogenated castor oil POE castor oil hydrogenated castor oil derivative such as maleic acid, POE beeswax lanolin derivative such as POE sorbit beeswax, coconut oil Fatty acid diethanolamide, lauric acid monoethanolamide,
Alkanol amides such as fatty acid isopropanolamide, POE propylene glycol fatty acid ester, PO
Examples thereof include E alkylamine, POE fatty acid amide, sucrose fatty acid ester, POE nonylphenylformaldehyde condensate, alkylethoxydimethylamine oxide, and trioleylphosphoric acid.

In addition, antiseptics such as ethylparaben and pentylparaben, glycyrrhizic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, anti-inflammatory agents such as hinokitiol, zinc oxide, and allantoin, placenta extract, glutathione, Yukinoshita extract and other whitening agents. , Shikon, birch, sage, loquat, aloe, iris, grape, yokinin, loofah, lily, saffron, senkyu, ginger, onionis, garlic, willow, extracts such as Japanese lantern, cooling agents such as menthol, camphor, royal jelly, ATP, photosensitizer, cholesterol derivative, activator such as calf blood extract, nonyl acid warenylamide, nicotinic acid benzyl ester, nicotinic acid β-butoxyethyl ester, capsaicin, zingerone, cantharisin tincture, ictamol, ta Nin acid, α- Poruneoru,
Tocopherol nicotinate, inositol hexanicotinate, cyclanderate, cinnarizine, trazoline, acetylcholine, verapamil, cepharanthin, γ
-There are blood circulation promoters such as oryzanol and antiseborrheic agents such as sulfur and thiantol.

Examples of natural water-soluble polymers include gum arabic, tragacanth gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seeds (quince), algecoloids (cassius extract), starches (rice, corn). , Potato, wheat), plant-based polymers such as glycyrrhizic acid, microbial-based polymers such as xanthan gum, dextran, succinoglucan, pullulan, collagen,
Animal-based macromolecules such as casein, albumin and gelatin can be mentioned.

As the semi-synthetic water-soluble polymer, for example,
Starch-based polymers such as carboxymethyl starch and methyl hydroxypropyl starch, methyl cellulose, nitrocellulose, ethyl cellulose, methyl hydroxypropyl cellulose, hydroxyethyl cellulose, sodium cellulose sulfate, hydroxypropyl cellulose, sodium carboxymethyl cellulose (CM
C), crystalline cellulose, cellulose-based polymers such as cellulose powder, and alginic acid-based polymers such as sodium alginate and propylene glycol alginate.

Examples of the synthetic water-soluble polymer include polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone, vinyl polymers such as carboxyvinyl polymer (Carbopol), and polyethylene glycol.
Polyoxyethylene polymers such as 2,000, 4,000, 6,000, copolymers such as polyoxyethylene polyoxypropylene copolymer, acrylic polymers such as sodium polyacrylate, polyethyl acrylate, polyacrylamide, polyethylene Examples include imines and cationic polymers.

Examples of the inorganic water-soluble polymer include bentonite, AlMg silicate (veegum), laponite, hectorite, and silicic acid anhydride.

Examples of the thickener include gum arabic, carrageenan, karaya gum, tragacanth gum, carob gum, quince seed (quince), casein, dextrin, gelatin, sodium pectate, sodium alginate, methyl cellulose, ethyl cellulose, C
MC, hydroxyethyl cellulose, hydroxypropyl cellulose, PVA, PVM, PVP, sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guar gum, tamarind gum, dialkyldimethylammonium sulfate cellulose, xanthan gum, magnesium aluminum silicate, bentonite,
Hectorite and the like can be mentioned.

As powder components, talc, kaolin, mica, sericite, muscovite, phlogopite, synthetic mica, phlogopite, biotite, lithia mica, vermiculite,
Magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, tungstate metal salt, magnesium, silica, zeolite, barium sulfate, calcined calcium sulfate (calculated gypsum), calcium phosphate, Fluorapatite, hydroxyapatite, ceramic powder, metallic soap (zinc myristate, calcium palmitate, aluminum stearate), inorganic powder such as boron nitride, polyamide resin powder (nylon powder), polyethylene powder, polymethylmethacrylate powder, polystyrene Powder, styrene-acrylic acid copolymer resin powder, benzoguanamine resin powder, polytetrafluoroethylene powder, organic powder such as cellulose powder, inorganic white such as titanium dioxide and zinc oxide Fee, iron oxide (red iron oxide),
Inorganic red pigments such as iron titanate, inorganic brown pigments such as γ-iron oxide, inorganic yellow pigments such as yellow iron oxide and ocher, and inorganic black pigments such as black iron oxide, carbon black, and lower titanium oxide. , Mango Violet, Cobalt Violet and other inorganic purple pigments, Chromium oxide, Chromium hydroxide, Cobalt titanate and other inorganic green pigments, Ultramarine blue, Navy blue and other inorganic blue pigments, Titanium oxide coated mica, Titanium oxide coated oxychloride Bismuth, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, pearl pigments such as fish scale foil, aluminum powder,
Metal powder pigments such as copper powder, Red No. 201, Red 2
02, red 204, red 205, red 220, red 226,
Red 228, Red 405, Stirrup 203, Lanting 204, Yellow
205, Yellow 401, Blue 404 and other organic pigments, Red 3
No., Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Kashi Nobori No. 205, Yellow No. 4, Yellow No. 5
No., Yellow No. 202, Yellow No. 203, Green No. 3, Blue No. 1, etc., organic pigments such as zirconium, barium or aluminum lake, natural pigments such as chlorophyll, riboflavin, crocin, anthraquinone, β-carotene, fragrance, water , Alcohol, titanium yellow, cursamine, safflower red, and other coloring agents can be appropriately blended as necessary.

The external preparation for skin according to the present invention may have any dosage form, for example, an oily preparation, a solubilizing system for lotion, an emulsion system such as emulsion or cream, or a gel, paste, pack,
Dosage forms such as plasters, sheets, ointments, dispersions and powders can be used.

[0065]

EXAMPLES The present invention will be described in more detail with reference to examples. The present invention is not limited to these examples. The blending amount is% by weight. Prior to the examples, the effect of the present invention is shown by experimental data.

1. Preparation of plant extract 1000 g of Kyonin (apricot seed dry matter) in 300 parts of water
It is heated and extracted with 0 ml at 90 to 95 ° C. for 2 hours, the extract is filtered, and then concentrated under reduced pressure to 300 g (dry matter conversion: 25
g) hot water extract of Kyounin was obtained. Also, 1,000 g of Kyounin (dried apricot seeds) was added to ethanol 3000.
90 ml to 90 ° C. for 2 hours, and the extract is filtered and concentrated under reduced pressure to give 300 g (dry matter conversion: 40
g) Kyonin ethanol extract was obtained. Extracts were obtained from other plants by the same procedure.

Experimental Example 1 Lipolytic effect [Evaluation method] Adipocytes were isolated from adipose tissue by Rodbel
1 method (M. Rodbell, JBC, 239 (2) .1964). 50 μl of adipocytes prepared from human adipose tissue obtained by liposuction was mixed with 200 μl of Hanks buffer containing 2.5% bovine serum albumin and 25 μl of the sample shown in Table 1.
1 of the mixed solution and incubated at 37 ° C. for 1 hour. The total extract concentration in each sample was 10%, and 2
The ratio with the extract when using one kind of drug was set to 1: 1. The xanthine derivative, escroside, and berberine were 0.02 mg / ml. 3 ml of chloroform: heptane: methanol (98: 98: 4) was added to the reaction solution, and the mixture was stirred to extract lipids. After removing the aqueous layer by suction, the method of Duncombe (Biochemical Journal, 88 (7), 19
63) Free fatty acid amount (μmol / ml packed cells /
h) was measured and used as the amount of degraded lipid. The experimental results are shown in Table 1
It shows in Table 2. As a reference example, norepinephrine (noradrenaline), which is conventionally known as a lipid decomposition accelerator, is used.
The results of measurement for (0.05 μg / ml) are also shown in Table 1.

[0068]

[Table 1] ────────────────────────────────   Sample Degraded lipid amount                                     (Μmol / ml packed cells / h) ──────────────────────────────── Not added 0.10 ± 0.02 Norepinephrine (0.05 μg / ml) 8.5 ± 0.3 Kyounin hot water extract 11.2 ± 0.4 Kyounin ethanol extract 10.5 ± 0.3 Peony hot water extract 11.3 ± 0.4 Tonin hot water extract 10.4 ± 0.3 Bukuryo ethanol extract 13.6 ± 0.3 Kyoukyo 1.3BG extract 12.7 ± 0.3 Keikai ethanol extract 12.4 ± 0.3 Keishi 1.3BG extract 12.9 ± 0.2 Chorei ethanol extract 13.4 ± 0.5 Sandalwood hot water extract 11.9 ± 0.3 Geothermal hot water extract 14.2 ± 0.4 Gypsophila ethanol extract 15.1 ± 0.2 Thai Sou hot water extract 11.8 ± 0.2 Touki ethanol extract 13.2 ± 0.3 Bakmondou hot water extract 12.5 ± 0.4 Mint hot water extract 12.4 ± 0.4 Takusha 1.3BG extract 12.3 ± 0.4 Bowfu ethanol extract 13.3 ± 0.3 Sansuyu hot water extract 15.9 ± 0.3 ────────────────────────────────

[0069]

[Table 2] ──────────────────────────────────   Sample Degraded lipid amount                                         (Μmol / ml packed cells / h) ────────────────────────────────── Kyounin hot water extract + Zyou hot water extract 17.1 ± 0.4 Kyounin ethanol extract + Touki ethanol extract 16.5 ± 0.4 Peony Peony Hot Water Extract + Mint Extract + Bowfu Extract 18.3 ± 0.5 Tonin hot water extract + Bukuryo ethanol extract 16.6 ± 0.5 ──────────────────────────────────

From Tables 1 and 2, Kyonin, Peonies, Tounin, Bukuryo, Kyoukyo, Keikai, Keishi, Chorei, Juniper, Diou, Senkyuu, Taiso, Touki, Bakumondou, Mint, Takusha, Boufu and Sanshuyu extracts are lipid-decomposed. Promote 2
It can be seen that the combination of two or more species further promotes lipolysis.

Example 1 Serum for Body (1) Phellinus linteus extract 5.0% by weight (2) Sanshuyu extract 3.0 (3) Glycine 1.0 (4) Sodium hyaluronate 0.01 (5) Glycerin 10.0 (6) 1,3-Butylene glycol 5.0 (7) Carboxyvinyl polymer 0.3 (8) Ethanol 7.0 (9) Polyoxyethylene (18) Oleyl alcohol ether 0.8 (10) Macadamia nuts Oil 0.5 (11) Polyvinyl alcohol 2.0 (12) Tocopherol acetate 0.01 (13) Methylparaben 0.15 (14) Perfume 0.1 (15) Menthol 0.5 (16) Potassium hydroxide 0.08 (17) Purified water Dissolve (1) to (7) in the residue (production method) (17), and separately add (9) to (15) in (8). Then (1
6) was added to obtain a body serum.

Comparative Example 1 Body Serum A body essence was prepared in the same manner as in Example 1 except that the pearl millet extract and the saury extract were replaced with purified water.

Experimental Example 2 Effect test by human [Evaluation method] Forty women in their 20s to 40s were asked to apply the body beauty essences of the formulations of Example 1 and Comparative Example 1 to the whole body in the morning and evening, and they were continuously used for 1 month. I was asked to. The body weight and body fat percentage (ratio of fat to the whole body) before and after continuous use were measured by a measuring device (body fat meter with a weight scale, manufactured by Tanita) based on the principle of bioimpedance measurement. The average values of body weight and body fat percentage before and after use were obtained. The results are shown in Table 3.

[0074]

[Table 3] ───────────────────────────────────                       Example 1 Comparative example 1               ──────────────────────────                 Before continuous use 1 month after continuous use Before continuous 1 month after continuous use ─────────────────────────────────── Weight (kg) 63.2 ± 1.2 60.5 ± 1.1 63.0 ± 1.1 63.3 ± 1.2 Body fat percentage (%) 35.1 ± 0.8 31.4 ± 0.9 34.1 ± 0.6 33.8 ± 0.9 ───────────────────────────────────

As is clear from the above results, when Example 1 which is the product of the present invention is used, the decrease in body weight and body fat percentage is remarkable as compared with before use, but in Comparative Example 1, Almost no decrease was seen.

Example 2 Lotion (1) Kyounin extract 30.0% by weight (2) Menthol 0.5 (3) Glycerin 4.0 (4) 1,3-Butylene glycol 4.0 (5) Tocopherol acetate 0.05 (6) Ethanol 7.0 (7) Polyoxyethylene (18) Oleyl alcohol ether 0.5 (8) Methylparaben 0.2 (9) Citric acid 0.05 (10) Sodium citrate 0.1 ( 11) Fragrance 0.05 (12) Purified water Citric acid, sodium citrate, glycerin, 1,3-butylene glycol, and Kyounin extract are dissolved in the remaining (manufacturing method) purified water (aqueous phase). Separately, polyoxyethylene oleyl alcohol ether, tocopherol acetate, fragrance, methylparaben, and menthol were dissolved in ethanol, and this was added to the above aqueous phase to solubilize it, followed by filtration to obtain a lotion.

Comparative Example 2 Lotion A lotion was prepared in the same manner as in Example 2 except that the Kyounin extract was replaced with purified water.

Example 3 Cream (1) Cetostearyl alcohol 3.5% by weight (2) Squalane 40.0 (3) Beeswax 3.0 (4) Reduced lanolin 5.0 (5) Ethylparaben 0.3 (6 ) Polyoxyethylene (20) sorbitan monopalmitic acid ester 2.0 (7) stearic acid monoglyceride 2.0 (8) sodium N-stearoyl glutamate 0.5 (9) 2-hydroxy-4-methoxybenzophenone 1.0 ( 10) Retinol acetate 2.0 (11) Evening primrose oil 0.05 (12) Fragrance 0.05 (13) Chorei extract 0.01 (14) Polyacrylic acid amide 0.5 (15) Bakumondou extract 5.0 (16) 1,3-Butylene glycol 1.5 (17) Purified water The residue (production method) (1) to (12) was dissolved by heating, and the mixture was stirred at (13) to (17) heated to 70 ° C. Want added. The mixture was treated with a homomixer to make the emulsified particles finer, and then rapidly cooled with stirring to obtain a cream.

Comparative Example 3 Cream A cream was prepared in the same manner as in Example 3 except that the Chorei extract and Bakumondou extract were replaced with purified water.

Example 4 Emulsion (1) Stearic Acid 1.5 wt% (2) Cetyl Alcohol 0.5 (3) Beeswax 2.0 (4) Polyoxyethylene (10) Monooleate 1.0 (5) ) Octyl methoxycinnamate 2.0 (6) Peony extract 1.0 (7) Tonin extract 1.0 (8) Bofu extract 1.0 (9) Sodium hyaluronate 0.01 (10) Triethanol Amine 0.75 (11) Glycerin 7.0 (12) Inosit 0.5 (13) Ginseng extract 0.5 (14) Ethylparaben 0.3 (15) Perfume 0.03 (16) Polyvinyl alcohol 1.0 ( 17) Purified water Residue (manufacturing method) Purified water with peony extract, boufu extract,
Tonin extract, sodium hyaluronate, glycerin, inosit, ginseng extract, caffeine, and triethanolamine are added and kept at 70 ° C (aqueous phase). Polyvinyl alcohol is dissolved in some water and added to the aqueous phase. The other ingredients are mixed, dissolved by heating and kept at 70 ° C. (oil phase). The oil phase is added to the aqueous phase for preliminary emulsification, and the mixture is homogenized with a homomixer. Then, it was rapidly cooled with stirring to obtain an emulsion.

COMPARATIVE EXAMPLE 4 Emulsion Example 4 except that the peony extract, the Bofufu extract and the Tounin extract in Example 4 were replaced with purified water.
An emulsion was prepared in the same manner as in.

Example 5 Foam pack (1) Bukyou extract 10.0% by weight (2) Cypress extract 10.0 (3) 1,3-butylene glycol 5.0 (4) Glycerin 7.0 (5) Methylparaben 0.1 (6) Potassium hydroxide 0.15 (7) Stearic acid 0.5 (8) Myristic acid 1.0 (9) Batyl alcohol 1.5 (10) Polyoxyethylene (60) Hydrogenated castor oil 3 .0 (11) Perfume 0.05 (12) Liquefied petroleum gas 6.0 (13) Dimethyl ether 3.0 (14) Purified water Residual (manufacturing method) (14) with (1) to (6) added to 70 ° C It is heated and dissolved in, and (7) to (11) are heated and stirred at 75 ° C, and the mixture is sufficiently stirred and then cooled. This was filled in a container, and finally (12) and (13) were filled as a propellant to obtain a foam pack.

Example 6 Ointment (1) Keikai extract 12.0 wt% (2) Takusha extract 1.0 (3) Retinol palmitate 0.5 (4) Stearyl alcohol 18.0 (5) Mokurou 20.0 ( 6) Polyoxyethylene (20) Monooleic acid ester 0.25 (7) Glycerin monostearic acid ester 0.3 (8) Vaseline 40.0 (9) Purified water Residue (manufacturing method) Purified water with cabbage extract, Takusha extract Is added and dissolved, and the mixture is maintained at 70 ° C (aqueous phase). 70 remaining ingredients
Mix and dissolve at ℃ (oil phase). The oil phase was added to the aqueous phase, and the mixture was uniformly emulsified with a homomixer and then cooled to obtain an ointment.

[0084] (Manufacturing method) Purified water with cabbage extract, juniper extract,
The dio extract, glycerin, 1,3-butylene glycol, and triethanolamine are added and kept at 70 ° C. (aqueous phase). The other ingredients are mixed, dissolved by heating and kept at 70 ° C. (oil phase). The oil phase is added to the aqueous phase for preliminary emulsification, and the mixture is homogenized with a homomixer. Then, it was rapidly cooled with stirring to obtain a milky lotion for massage.

Comparative Example 5 Milky lotion for massage In Example 7, a cabbage extract, a juniper extract,
A milky lotion for massage was prepared in the same manner as in Example 7 except that the extract of Diou was replaced with purified water.

Example 8 Gel for Massage (1) Touki Extract 0.5% by Weight (2) Gypsophila Extract 2.0 (3) Mint Extract 1.0 (4) Glycerin 50.0 (5) Carboxyvinyl Polymer 0.4 (6) Polyoxyethylene (10) Methyl polysiloxane copolymer 2.0 (7) Squalane 1.0 (8) Polyethylene glycol 400 30.0 (9) Arginine 0.24 (10) Perfume 0 .15 (11) Purified water Residue (manufacturing method) Purified water with Touki extract, Senkyu extract, mint extract, glycerin, polyethylene glycol 40
0, dissolve the carboxyvinyl polymer. Separately, a mixture of squalane, polyoxyethylene (10) methylpolysiloxane copolymer, and fragrance was added, and then arginine was added to obtain a massage gel.

Comparative Example 6 Massage Gel A massage gel was prepared in the same manner as in Example 8 except that purified water was used in place of the Touki extract, Senkyu extract and mint extract.

Experimental Example 3 Usage Test Using the external preparations of Examples 1 to 4, 7, 8 and Comparative Examples 1 to 6, 40 women (20 to 40 years old) were subjected to a usage test for 1 month. It was After use, (1) the tightness of the skin,
The slimming effect was determined by a questionnaire survey regarding (2) skin swelling, (3) skin elasticity, and (4) skin roughness improving effect. The results are shown in Tables 4 and 5.

[0089]

[Table 4] ────────────────────────────────               (1) Tightening of the skin (2) Swelling of the skin               Very good good average very good good ordinary ──────────────────────────────── Example 1 26 11 3 10 20 10 Comparative Example 1 3 6 31 5 13 22 ──────────────────────────────── Example 2 15 19 4 28 8 4 Comparative Example 2 7 6 27 5 10 25 ──────────────────────────────── Example 3 16 17 7 23 15 2 Comparative Example 3 4 8 28 7 7 26 ──────────────────────────────── Example 4 27 12 1 12 18 10 Comparative Example 4 3 8 29 6 10 24 ──────────────────────────────── Example 7 13 18 9 15 18 7 Comparative Example 5 3 7 30 2 13 15 ──────────────────────────────── Example 8 26 13 1 24 8 8 Comparative Example 6 3 7 30 8 10 22 ────────────────────────────────

[0090]

[Table 5] ────────────────────────────────               (3) Elasticity of the skin (4) Rough skin improving effect               Very good good average very good good ordinary ──────────────────────────────── Example 1 15 21 4 28 9 3 Comparative Example 1 6 11 23 10 10 20 ──────────────────────────────── Example 2 24 11 5 25 11 2 Comparative Example 2 3 9 28 20 12 8 ──────────────────────────────── Example 3 22 15 3 25 12 3 Comparative Example 3 3 7 20 10 10 20 ──────────────────────────────── Example 4 15 18 7 13 20 7 Comparative Example 4 5 15 20 7 11 22 ──────────────────────────────── Example 7 12 20 8 30 5 5 Comparative Example 5 4 15 21 15 10 15 ──────────────────────────────── Example 8 25 8 7 32 8 0 Comparative Example 6 5 15 20 10 10 20 ────────────────────────────────

From Tables 4 and 5, it was revealed that the external preparation for skin containing the plant extract of the present invention exhibits an excellent slimming effect.

[0092]

Industrial Applicability As described above, the lipolysis-promoting agent of the present invention and the slimming skin external preparation containing the same are excellent in the effect of promoting lipolysis.

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Claims (3)

[Claims] 1. Kyonin, peony, tounin, bukuro, kyokyo, Keikai, Keishi, Chorei, juniper, zelkova, senkyu, tanso, touki,
An agent for promoting lipolysis, which comprises an extract extracted from one kind or two or more kinds of Bakumondou, mentha, takusha, bowhu, and Sanshuyu. 2. Kyonin, peony, Tounin, Bukuro, Kyoukyo, Keikai, Keishi, Chorei, juniper, zelkova, senkyu, tanso, touki,
A slimming skin external preparation comprising an extract, which is extracted from one or more kinds of bakumondou, mentha, takusha, bofu and sanshuyu, as an active ingredient. 3. Kyonin, peony, Tounin, Bukuro, Kyoukyo, Keikai, Keishi, Chorei, juniper, zelkova, senkyu, tanso, touki,
The extract which is extracted from one or two or more kinds of Bakumondou, mint, takusha, bowfu and sanshuyu, and one or more kinds selected from the following (A) are blended as an active ingredient. Skincare external preparation for slimming. (A) xanthine derivative, Lavandula genus plant extract, Apiaceae fennel plant extract, inosit, dextran sulfate, seaweed extract, amino acid, escroside, citrus plant extract, β-adrenergic stimulant,
α2 adrenergic inhibitor, bipyridine derivative, pepper plant extract, thistle plant extract, tea extract, Coptis extract, Oat extract, Berberine-type alkaloids, Ginkgo biloba extract, Ginseng extract, Pteris chinensis extract, Centella asiatica extract, Butcher bloom extract, mallow extract, turmeric extract, thyme extract, arnica extract, ginkgo extract, horse chestnut extract, capsicum extract, ivy extract, mannen wax,
Calendula, Salvia, St. John's wort, Astragalus extract, Ginger, Rosemary extract, Anethole, Saponins, Horsetail extract, Clematis extract and Amaranthaceae plant extract