JP2001031554A - Preparation for external use for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a preparation for external use for the skin, excellent in an improving effect on the rough skin. SOLUTION: This preparation contains (A) a Lupinus albus seed extract, (B) a liquid crystal forming component composed of at least one compound selected from the group consisting of cholesterol, ceramicd and a derivative thereof, and a phospholipid, and (C) a humectant.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an external preparation for skin having an excellent effect of improving skin roughness.

[0002]

2. Description of the Related Art Conventionally, skin external preparations such as emulsions, creams, lotions, packs, dispersions, cleansers, ointments, and external preparations have been used for various purposes in order to impart predetermined medicinal effects to them. Ingredients have been added. For example, for the purpose of improving skin roughness, medicinal ingredients such as glycerin, phospholipid, mucopolysaccharide, and aloe extract are added.

[0003]

However, skin external preparations simply containing these medicinal components do not have sufficient effects of the medicinal components or, if added in an amount sufficient to obtain the medicinal effects, may have poor stability. In some cases, chipping or feeling of use may be poor, and improvement has been desired.

[0004]

Means for Solving the Problems The present inventors have conducted intensive studies to improve the effect of the medicinal component, and as a result, it has been found that combining the extract of Hauchiwa-bean with a specific liquid crystal forming component provides an excellent effect of improving rough skin. Was obtained, and it was found that when a humectant was added thereto, the effect was more excellent, and the present invention was completed.

[0005] That is, the present invention relates to the following components (A) and (B): (A) Extract of bean seeds (B) One or more selected from cholesterol, ceramide and derivatives thereof, and phospholipids The present invention provides a skin external preparation characterized by comprising a liquid crystal forming component, and further comprising a humectant as the component (C) and having an excellent skin roughness improving effect. .

[0006]

DETAILED DESCRIPTION OF THE INVENTION The component of the present invention, component A of the present invention, is a plant belonging to the family Leguminosae, and is, for example, a legume (Lupinus albus).
Is obtained by adding water to the pulverized powder of the seeds and extracting the water, and preferably obtained by adding a proteolytic enzyme during the water extraction and hydrolyzing.

[0007] As an example of a preferable preparation method, hydrolysis is performed by adding water and a proteolytic enzyme to the ground powder of the seeds of lupine (Lupinus albus).
After leaving the obtained extract at a low temperature for 2 to 3 days, filtration is performed, and the obtained filtrate is left to mature for about 5 days, and filtration is performed again.

[0008] The component of (A) of the present invention, a lupine bean seed extract, promotes the production of filaggrin, which is the source of the skin's natural moisturizing factor (NMF). Preferably 0.00
01 to 5% by weight (hereinafter simply referred to as "%"), more preferably 0.001 to 3%. The effect of the present invention is better exhibited when the content of the extract of the lupine seed is within this range.

The liquid crystal forming component as the component (B) of the present invention comprises one or more selected from cholesterol, ceramide and derivatives thereof, and a phospholipid. Specifically, the following are mentioned, for example.

As cholesterol and its derivatives,
As cholesterol, phytosterol, cholesteryl hydroxystearate, cholesteryl stearate, polyoxyethylene-added cholesterol, macadamian nut oil fatty acid cholesteryl, ceramide and derivatives thereof, galactosylceramide, glucoceramide, stearoyl phytosphingosine, phospholipid, egg yolk or And soybean-derived phospholipids and hydrogenated products thereof.

The liquid crystal-forming component (B) of the present invention has the effect of retaining water in its structure and efficiently delivering moisture to the skin. 0001-5%, more preferably 0.0001-3%. A more remarkable effect can be obtained when the proportion of the phospholipid in the liquid crystal forming component is 50% or more.

The humectant as the component (C) of the present invention is not particularly limited. Examples thereof include glycine, serine, aspartic acid, glutamic acid, asparagine, glutamine, proline, hydroxyproline, citrulline, and theanine.
Amino acids such as pyrrolidonecarboxylic acid and derivatives thereof, sorbitol, erythritol, maltitol, xylitol, trehalose, sucrose, sugars such as glycogen and derivatives thereof, D-panthenol and derivatives thereof,
Plant extracts having a moisturizing effect such as almond extract, coltsfoot extract and raspberry extract, α-hydroxy acids such as citric acid, lactic acid and glycolic acid, glycols such as 1,3-butylene glycol and glycerin, and alkali simple Hot spring water, deep sea water and the like can be mentioned, and one or more of these can be appropriately selected and used.

The content of the humectant as the component (C) of the present invention is preferably 0.0001 to 5%, more preferably 0.001 to 3%. The extract may be in this range as dry solids. When the content of the moisturizing agent of the component (C) of the present invention is within this range, when the extract is used in combination with the component (A) of the lupine seed extract and the component (B) of the liquid crystal forming component, the skin external preparation of the present invention will A skin external preparation having good stability over time and an excellent effect of improving skin roughness without affecting the extract of peanut seeds and liquid crystal-forming components.

The form of the external preparation for skin of the present invention is not particularly limited, and examples thereof include skin care cosmetics such as milky lotions, creams, lotions, packs, cleaning agents, makeup cosmetics such as lipsticks and foundations, and scalp cosmetics. Ingredients, ointments,
Dispersion, can be a drug such as a liquid for external use, etc., there is no particular limitation on the dosage form, solid, paste, mousse, gel, powder, solution, solubilization,
It can be emulsified, powder dispersed, or multilayer.

In addition to the components (A), (B) and (C), the external preparation for skin of the present invention usually contains cosmetics, quasi-drugs, and the like, as long as the effects of the present invention are not impaired. Ingredients used in the preparation of topical medicines, such as water, oils, surfactants, metal soaps, gelling agents, powders, alcohols, water-soluble polymers, film-forming agents, resins, UV protection agents,
Clathrate compounds, antibacterial agents, fragrances, deodorants, salts, pH regulators, cooling agents, extracts from animals and microorganisms, plant extracts, blood circulation promoters, astringents, antiseborrheic agents, active oxygen scavengers, Cell activators, whitening agents, anti-inflammatory agents, keratolytic agents, enzymes, hormones, vitamins and the like can be added as appropriate.

[0016]

EXAMPLES The present invention will be described in more detail with reference to Reference Examples and Examples, which should not be construed as limiting the present invention.

REFERENCE EXAMPLE 1 Production of Ginger Seed Extract 1 g of purified water and 1 L of proteolytic enzyme were added to the ground powder of 50 g of ginger (Lupinus albus) seeds, hydrolyzed, left at low temperature for 2 to 3 days, and then filtered. Then, the obtained filtrate was left to mature for about 5 days, and then filtered again to obtain a pickle seed extract (dry solid content: 5.0%).

Reference Example 2 Preparation of Almond Extract 100 g of almond seeds (sweet peach) were cut into small pieces, 100 ml of purified water was added thereto, and the mixture was extracted at room temperature for 3 days with occasional stirring, followed by filtration to obtain an almond extract. (3.0% dry solids).

REFERENCE EXAMPLE 3 Preparation of coltsfoot extract A 10% coltsfoot flower was cut into pieces, 50 ml of 50% 1,3-butylene glycol was added, extracted at room temperature for 7 days with occasional stirring, and filtered to obtain a coltsfoot extract. (1.5% dry solids).

Example 1 Emulsion Emulsion was prepared according to the composition shown in Table 1 and the following method, and the effect of improving skin roughness was examined. Table 1 also shows the results.

[0021]

[Table 1]

* 1 Nikko Chemicals * 2 Wako Pure Chemical * 3 Manufactured in Reference Example 1 * 4 Ajinomoto Co. * 5 Manufactured in Reference Example 2 * 6 Manufactured in Reference Example 3

(Production method) A. Components (1) to (7) are mixed and heated to 70 ° C. B. A portion of components (13), (15) and (16) are mixed and heated to 70 ° C. C. Add B to A, mix and cool. D. (8) to (12), (14) and the remaining (1)
6) was added to obtain an emulsion.

(Test Method) Fifteen healthy persons aged 26 to 44 years were used as panels, and the skin condition before experimental skin roughness was photographed with a microscope camera, and the score was determined according to the following criteria. Experimental rough skin was caused by treating the upper arm flexion side with a mixed solution of ether and acetone (1: 1). Thereafter, the test emulsion was applied twice a day, in the morning and at night, for 14 days, and scores of the skin condition were obtained in the same manner as described above 1, 3, 7 and 14 days after the occurrence of rough skin. The scores were averaged to evaluate the effect of improving skin roughness.

[Skin Condition Score] <Score> <State> 1 Skin groove of skin is unclear and exfoliation of keratin is recognized. 2 Skin crevices are slightly unclear or strongly unidirectional. 3 Skin sulcus is recognized but shallow or strongly unidirectional. 4 Skin sulcus is recognized or slightly reticulated. 5 Skin crevices are clearly recognized or have a fine mesh.

As is evident from the results in Table 1, the emulsion of the product of the present invention had a better skin roughness improving effect than the comparative product.

Example 2 Lotion (Formulation) (%) (1) Glycerin 5.0 (2) 1,3-butylene glycol 6.5 (3) Hydrogenated soybean phospholipid * 1 1.0 (4) Cholesterol * 2 0.5 (5) Polyoxyethylene (20EO) Sorbitan monolaurate 1.2 (6) Ethyl alcohol 8.0 (7) Extract of bean seeds * 3 1.0 (8) L-serine * 4 0.5 (9) Coltsfoot extract * 5 1.0 (10) Suitable amount of preservative (11) Suitable amount of fragrance (12) Remaining purified water * 1 Nikko Chemicals * 2 Wako Pure Chemical * 3 Reference Example * 4 Manufactured in Ajinomoto Co. * 5 Manufactured in Reference Example 3

(Production method) A. Components (1), (3), (4), (5) and (10)
And dissolve while heating. B. Components (2), (6) to (9), (11) and (1)
2) is mixed and dissolved. C. A and B were mixed and made uniform to obtain a lotion.

Example 2 was a lotion having excellent stability over time and an excellent effect of improving rough skin.

Example 3 Ointment (Formulation) (%) (1) Stearic acid 18.0 (2) Cetanol 4.0 (3) Hydrogenated egg yolk phospholipid * 1 1.0 (4) Polyoxyethylene-added cholesterol * 2 0.5 (5) Triethanolamine 1.0 (6) Ceramide * 3 0.2 (7) Glycerin 5.0 (8) Dipterocarp seed extract * 4 0.2 (9) Raspberry extract * 50 .3 (10) Glycogen * 6 0.5 (11) Preservative appropriate amount (12) Alkaline simple hot spring water * 7 Remaining * 1 Asahi Kasei * 2 Nikko Chemicals * 3 Nikko Chemicals * 4 Reference Example 1 * 5 AMI Co., Ltd. * 6 KUPI Co., Ltd. * 7 Maruzen Pharmaceutical Co., Ltd.

(Production method) A. Components (1) to (4), (6) and (11) as (7)
And heat to 75 ° C. B. Heat and mix a part of components (5) and (12),
Keep at ° C. C. Add A slowly to B. D. C was dissolved in the remaining (12) while cooling (8)
To (10) was added to obtain an ointment.

Example 3 was an ointment effective for improving skin roughness.

Example 4 Pack (Formulation) (%) (1) Polyvinyl alcohol 20.0 (2) Ethanol 20.0 (3) Glycerin 5.0 (4) Soybean lecithin * 1 0.5 (5) Phytosterol * 2 0.2 (6) Kaolin 6.0 (7) Ginger peanut seed extract * 3 0.2 (8) Preservative appropriate amount (9) Flavor appropriate amount (10) Purified water remaining amount * 1 Nikko Chemicals * 2 Eisai * 3 Manufactured in Reference Example 1

(Production method) A. Mix components (1), (2), (6) and (10), heat to 70 ° C. and stir. B. Heat and mix components (3), (4) and (5). C. The above B was added to the above A, mixed, cooled, and (7), (8) and (9) were uniformly dispersed to obtain a pack.

Example 4 was a pack for providing moisture to the skin.

Example 5 Detergent (Formulation) (%) (1) Stearic acid 10.0 (2) Palmitic acid 8.0 (3) Myristic acid 12.0 (4) Lauric acid 4.0 (5) Oleyl Alcohol 1.5 (6) Purified lanolin 1.0 (7) Egg yolk lecithin * 1 0.5 (8) Ceramide * 2 0.3 (9) Fragrance appropriate amount (10) Preservative appropriate amount (11) Glycerin 18.0 ( 12) Potassium hydroxide 6.0 (13) Peanut seed extract * 3 0.5 (14) Theanine * 4 0.1 (15) Purified water balance * 1 Asahi Kasei * 2 Nikko Chemicals * 3 Reference Manufactured in Example 1 * 4 Taiyo Chemical Co., Ltd.

(Production method) A. Mix part of components (11), (12) and (15) and heat to 70 ° C. B. Mix components (1) to (8) and (10),
Heat to C. The above B was added to the above A, and kept at 70 ° C. for a while. After the reaction was completed, the mixture was cooled to 50 ° C., and the components (9) and (13)
And the remaining (14) dissolved in (15) was added, and cooled to obtain a washing agent.

In Example 5, the skin after washing was moisturized,
It was a cleansing agent that prevented the skin from becoming bulky.

[0039]

EFFECTS OF THE INVENTION The skin preparation for external use of the present invention contains a liquid extract-forming component comprising an extract of peanut seeds, one or more selected from cholesterol, ceramide and derivatives thereof, and a phospholipid, and further has a moisturizing effect. By containing the agent, it has an excellent effect of improving rough skin and is extremely useful in beauty and medical treatment.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification FI FI Theme Court ゛ (Reference) A61K 35/78 A61K 35/78 J (72) Inventor Masahiro Moriyama 48-18 Sakaemachi, Kita-ku, Tokyo Co., Ltd. 4C083 AA082 AA111 AA112 AA162 AB032 AB442 AC012 AC022 AC072 AC102 AC122 AC182 AC242 AC442 AC542 AC582 AC641 AD112 AD352 AD412 AD491 AD492 AD512 AD571 AD572 BB51 CC02 CC04 CC05 CC07 CC23 DD22 DD23 DD01 FF31 AB AB52 AB59

Claims (5)

[Claims] 1. A liquid crystal-forming component comprising the following components (A) and (B): (A) Extract of peanut seeds; (B) one or more selected from cholesterol, ceramide and derivatives thereof; and a phospholipid. An external preparation for skin, comprising: 2. The topical skin preparation according to claim 1, wherein the content of the component of (A), the pickled bean seed extract, is 0.0001 to 5% by weight as a dry solid content. 3. The external preparation for skin according to claim 1, wherein the content of the liquid crystal forming component (B) is 0.0001 to 5% by weight. 4. The external preparation for skin according to claim 1, further comprising a humectant as the component (C). 5. The content of the humectant of component (C) is 0.00
The external preparation for skin according to claim 4, wherein the amount is from 01 to 5% by weight.