JP2001299939A - Surface irradiation type photodynamic diagnostic or therapeutic light device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a small-sized and inexpensive surface irradiation type photodynamic diagnostic or therapeutic light device by use of a light source for emitting lights of a wide wavelength band and an optical filter. SOLUTION: This device comprises the light source 12 for emitting lights of a wide wavelength band including visible rays, a concave mirror 14 and concave lens 25 for surface radiating the lights from the light source 12, optical fibers 21 and 22 for selectively transmitting the light of a specified wavelength band of the lights emitted from the light source 12, and a filter mounting means 20 for inserting and pulling out the optical filters into and from an optical path 12a. The light of the specified wavelength band is emitted to a focus part of the body surface having a photosensitive material preliminarily accumulated or applied thereon, and the photosensitive material is optically excited to perform a photodynamic diagnosis and/or a photodynamic therapy.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a surface irradiation type photodynamic diagnosis / treatment light device, and more particularly, to a photodynamic diagnosis (irradiation method) by irradiating a surface of a human body or the like on which a photosensitive substance is accumulated or applied. PDD: Photo Dynamic D
iagnosis or photodynamic therapy (PDT:
The present invention relates to a surface irradiation type photodynamic diagnostic / therapy light beam device that performs Photo Dynamic Therapy.

[0002]

2. Description of the Related Art In recent years, photodynamic therapy has been attracting attention as a new treatment technique for tumors such as cancer (including other affected sites. The same applies hereinafter). In photodynamic therapy, a photosensitizer with tumor affinity is administered to a patient (including a subject; the same applies hereinafter), and a laser beam in a specific wavelength band is applied to the tumor in which the photosensitizer is accumulated. In this method, photosensitizers are photoexcited to generate active oxygen, and tumors are destroyed and necrotic by the strong oxidizing power of active oxygen. Unlike photosurgical surgery, photodynamic therapy can be performed with little effect on normal tissues, and is said to have high post-operative quality of life (QOL: Quality of Life).

[0003] In addition, photodynamic diagnosis in which diagnosis is performed on the same principle as photodynamic therapy is also performed. Photodynamic diagnosis is caused by photoexcitation of a photosensitizer by administering a tumor-sensitive photosensitizer to the patient and irradiating the tumor with the photosensitizer with a laser beam in a specific wavelength band. By observing the fluorescence, the presence / absence, existence site, spread and the like of the tumor are diagnosed. Photodynamic therapy and photodynamic diagnosis are generally performed endoscopically, except for external tumors such as skin cancer.

[0004]

As described above, in the conventional photodynamic therapy and photodynamic diagnosis, a laser beam in a specific wavelength band is used for photoexciting a photosensitizer. There is a problem that it is necessary to use a large and expensive laser light generator such as an excimer laser. In addition, the laser beam output from the laser light generator is a light beam of a specific wavelength band, and the photosensitizer differs depending on the tumor to be subjected to photodynamic treatment and the tumor to be subjected to photodynamic diagnosis. Therefore, a single laser light generator limits the tumors to be subjected to photodynamic therapy and the tumor to be subjected to photodynamic diagnosis, and a special laser light generator that is different for each tumor is required. There was a problem that there was no.

Further, the above-mentioned diagnosis and treatment involves outputting a laser beam in the form of a spot, and for example, a photodynamic diagnosis and / or a photodynamic treatment for a widespread lesion such as skin cancer. In the case of performing the method, it is necessary to scan a lesion over a wide area with a spot-like laser beam, and there is a problem that a long time is required for photodynamic diagnosis and / or photodynamic treatment.

The present invention has been made in view of such a problem, and an object of the present invention is to provide a small-sized and inexpensive surface using a light source and an optical filter that emit light in a wide wavelength band. It is an object of the present invention to provide an irradiation-type photodynamic diagnostic / treatment optical device. In addition, using a light source that emits light in a wide wavelength band and an optical filter, for surface irradiation type photodynamic diagnosis and treatment that can be used for multiple photosensitizers, that is, multiple types of tumors, for general use. A light beam device is provided.

[0007]

In order to achieve the above object,
The surface irradiation type photodynamic diagnostic / therapeutic light device according to the present invention includes a light source that emits light in a wide wavelength band including visible light, an optical unit that performs surface irradiation with light from the light source, and light emitted from the light source. The optical filter is characterized by comprising an optical filter that selectively transmits a light beam of a specific wavelength band among the light beams to be transmitted, and a filter mounting unit that inserts and removes the optical filter into and from the optical path of the light source.

[0008] In a preferred specific embodiment of the light beam apparatus for photodynamic diagnosis and treatment according to the present invention, the optical filter corresponds to a photosensitizer for photodynamic treatment and / or photodynamic diagnosis. It preferably transmits light in a specific wavelength range, and preferably includes output adjusting means for adjusting the intensity of the light emitted by the light source. The light source may be an ultraviolet lamp, a halogen lamp, a metal halide lamp, a xenon lamp, and a white LED. It is preferable that any one of these or a plurality of them be combined. The optical means preferably comprises a concave mirror and a concave lens, and preferably comprises a concave mirror, a concave lens and a convex lens.

Further, as another preferred specific embodiment of the light beam apparatus for photodynamic diagnosis and treatment according to the present invention, the filter mounting means includes a support plate having a mounting groove for inserting the optical filter. It is characterized by the following. The filter mounting means includes a filter switching mechanism for selectively inserting and removing the optical filter into and from the optical path of the light source, wherein the filter switching mechanism arranges a plurality of optical filters on a circumference. It is preferable that a switching plate is provided, and one of the plurality of optical filters is selectively inserted into and removed from the optical path by rotating the switching plate, and the plurality of optical filters are arranged horizontally. A switching plate may be provided, and one of the plurality of optical filters may be selectively inserted into and removed from the optical path by sliding the switching plate. Further, the filter switching mechanism may include a plurality of swingable switching plates for mounting the optical filters, and may be configured to swing the switching plates to selectively insert and remove the optical filters in the optical path. Good.

The light source device includes a control device, and the filter switching mechanism includes drive means for moving the optical filter, and the drive means is driven based on an output signal of the control device to control the optical filter. Is moved, and the optical filter is selectively inserted into and removed from the optical path of the light source.

The surface irradiation type photodynamic diagnosis / treatment light device of the present invention thus constructed can switch the optical filter to perform the photodynamic diagnosis with the light in the specific wavelength range, and can perform the optical filter. Can be switched to perform photodynamic treatment with light in a specific wavelength range. This diagnosis can be made by inserting a photodynamic diagnostic optical filter into the lesion on the body surface where the photosensitizer has been accumulated in advance, irradiating light, and visually checking the fluorescence generated by photoexcitation of the photosensitizer. it can. In the above-mentioned treatment, an optical filter for photodynamic treatment is inserted into a lesion on a body surface in which a photosensitizer has been accumulated in advance, and a light beam is irradiated. It causes cell death.

Therefore, it is possible to provide an inexpensive optical device for photodynamic diagnosis and treatment which does not require an expensive laser light generator, is simple in construction, and inexpensive. The optical filter is provided with a plurality of optical filters for transmitting light in a specific wavelength range corresponding to a photosensitizer for photodynamic therapy and / or photodynamic diagnosis, and is capable of treating various tumors to be treated. Can be.

The filter mounting means allows the optical filter to be inserted into and removed from the mounting groove of the support plate by manual operation, so that the configuration is simplified and the insertion and removal operation can be easily performed.
Switching of photodynamic therapy can be easily performed. The filter mounting means is configured by a filter switching mechanism that selectively inserts and removes the optical filter into the optical path of the light source, and the filter switching mechanism is configured to include a switching plate that arranges a plurality of optical filters on a circumference, When a switching plate for horizontally disposing a plurality of optical filters is provided, the optical filters can be selectively inserted into and removed from the optical path automatically, and switching between photodynamic diagnosis and photodynamic therapy is easy. Can be done. If the filter switching mechanism can be driven by the control device via the driving means, the doctor can automatically switch the filter using the instruction switch or the like, and the burden on the patient can be minimized.

[0014]

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a perspective view showing an embodiment of a surface irradiation type photodynamic diagnosis / treatment beam apparatus according to the present invention. FIG. 1 is a schematic perspective view showing a surface irradiation type photodynamic diagnostic / therapeutic light beam device according to the embodiment and an irradiation range of the light beam. FIG. 2 is a surface irradiation type photodynamic diagnostic / therapeutic light beam shown in FIG. FIG. 3 is a cross-sectional view taken along line AA of FIG. 2 showing a main configuration of the device. 1 to 3, a surface irradiation type photodynamic diagnosis / treatment light device (hereinafter, referred to as a light device) 10 according to the present embodiment includes a main body 11 and visible light arranged in the main body 11. A light source 12 that emits light in a wide wavelength band, a plurality of optical filters 21 and 22 that transmit light of a specific wavelength range among light emitted from the light source 12, and an optical filter 21 in an optical path 12 a of the light source 12. , 22 for selectively inserting and removing the filter.

The light source 12 is a relatively inexpensive ultraviolet lamp,
In addition to halogen lamps, metal halide lamps, cannon lamps, white LEDs (Light Emitting
Diode) or the like may be used alone or in combination of two or more, and may emit light in a wide wavelength band of about 400 to 700 nm. Further, the output variable power supply means 13 can adjust the voltage, for example, by the output adjustment dial 13a, and the light source 12 easily adjusts the intensity (light emission amount) of the light beam emitted by the output variable power supply means 13, such as a volume. Can be adjusted.

A concave mirror 14 is located around the light source 12 as an optical means for condensing light rays emitted from the light source, and the concave mirror 14 is attached to the support plate 1 fixed to the connecting plate 15.
6 fixed. Note that a mirror-integrated light source in which the concave mirror 14 and the light source 12 are integrally formed may be used. In addition, the concave mirror 14 may use a cold mirror for cutting a heat ray region. A socket 12b for supplying power is connected to a rear portion of the light source 12.

The supporting plates 23 and 24 constituting the filter mounting means 20 are arranged and fixed on the connecting plate 15 in the light beam direction.
2 can be inserted and removed manually. Optical filter 21,
Reference numeral 22 denotes a unit which is inserted from an opening / closing lid 11 a provided at an upper portion of the main body 11 and can be inserted into and removed from the optical path 12 a of the light source 12. That is, the mounting grooves 2 are provided in the support plates 23 and 24.
3a and 24a are formed, and a frame plate for supporting predetermined optical filters 21 and 22 can be inserted into the grooves 23a and 24a by being dropped from the outside of the main body 11.

Optical filter 21 and optical filter 22
For example, a band-pass filter that transmits only light having a desired narrow wavelength band, a cut filter that transmits light having a wavelength equal to or greater than a predetermined wavelength or equal to or less than a predetermined wavelength is used. Depending on the selection and combination of the optical filter 21 and the optical filter 22, for example, 400 to 500 nm, 500 to 60
It is possible to selectively transmit only light in a specific wavelength band such as 0 nm, 600 to 700 nm, and 700 to 800 nm, or light having a predetermined wavelength or more or a predetermined wavelength or less. The reason why the wavelength band to be transmitted is subdivided in this way is that the wavelength band of the light to be excited is different depending on the tumor-sensitive photosensitizer administered to the patient.

An irradiation hole 24b is formed in the center of the third support plate 24, and the light emitted from the light source 12 is condensed in the irradiation hole 24b. Optical path 12a described above
Corresponds to the focused portion. And irradiation hole 2
For example, a concave lens 25 is fixed as an optical unit for irradiating the surface 4b with a light beam from the light source 12 to 4b. The concave lens 25 diverges the light beam condensed by the concave mirror, and defines an irradiation range 26 having a diameter D on a surface separated from the main body 11 by a predetermined distance. The body 11 has a concave lens 2
5, an irradiation window 27 made of transparent glass or the like is fixed.

The operation of the surface irradiation type photodynamic diagnosis / therapy light beam device 10 according to the present embodiment having the above-described configuration will be described below. Here, a case where a photodynamic diagnosis and a photodynamic treatment are performed on skin cancer will be described as an example.

(1) Photodynamic Diagnosis First, a physician injects a patient with a tumor-sensitive photosensitizer (eg, a polyfin photosensitizer, a chlorin photosensitizer, etc.) intravenously. Thereafter, the patient is kept in a dark room for a predetermined time (for example, 24 to 48 hours) according to the type of the photosensitive substance. By waiting, the photosensitizer accumulates in the cancer cells, while it is metabolized from normal cells, resulting in the photosensitizer remaining only in the cancer cells.
accumulate. In addition, a photosensitizer may be applied to a lesion part of the skin, and the photosensitizer may be accumulated after waiting for a predetermined time.

After a lapse of a predetermined time, the doctor sets the light beam device 10
, The optical filter 21 for photodynamic diagnosis is inserted into the mounting groove 23a of the support plate 23, and the optical path 12a of the light source 12 is
The light source 12 is turned on. The light in the wide wavelength band emitted from the light source 12 is reflected and condensed by the concave mirror 14, passes through the optical filter 21 for the photodynamic diagnosis, and emits the light in the wavelength band for the photodynamic diagnosis (specifically, Is only black light of short wavelength from blue to ultraviolet region),
The light is focused near the irradiation hole 24b. The light beam condensed near the irradiation hole 24b spreads through the concave lens 25 which is an optical means, and is irradiated on the irradiation range 26.

When the physician positions the lesion of the patient in the irradiation area 26, the photosensitizer accumulated in the cancer cells is photoexcited by the light in the wavelength band for photodynamic diagnosis to generate fluorescence. For this reason, a physician can perform a photodynamic diagnosis of the presence, absence, location, spread, and the like of cancer cells based on the fluorescent image. The location of the diagnosed cancer cells is marked using, for example, a writing instrument. At this time, the doctor
By operating the output adjustment dial 13a as necessary, the intensity of the light emitted by the light source 12 can be changed, and the brightness of the fluorescence emitted by the cancer cells can be adjusted.

(2) Photodynamic treatment First, a physician injects a tumor-friendly photosensitizer into a patient intravenously as in the case of photodynamic diagnosis. The photosensitizer used at this time may be the same as in the case of the photodynamic diagnosis or may be different depending on the tumor to be treated. Thereafter, as in the case of the photodynamic diagnosis, the patient is kept in a dark room for a predetermined time (for example, 24 to 48 hours) corresponding to the type of the photosensitizer. By waiting, the photosensitizer accumulates in the cancer cells while being metabolized from the normal cells. As a result, the photosensitizer remains and accumulates only in the cancer cells.

After a lapse of a predetermined time, the doctor sets the light beam device 10
, An optical filter 22 for photodynamic diagnosis is inserted into the mounting groove 24a of the support plate 24, and the optical path 12a of the light source 12 is
The light source 12 is turned on. The light in the wide wavelength band emitted from the light source 12 is reflected and condensed by the concave mirror 14, passes through the optical filter 22 for photodynamic therapy, becomes only the light in the wavelength band for photodynamic therapy, and is irradiated. Hole 2
The light is focused near 4b. The light beam condensed near the irradiation hole 24b spreads through the concave lens 25, and is irradiated to the irradiation range 26.

The doctor places the marked portion of the patient in the irradiation area 26 and irradiates the cancer cells with light in a wavelength band for photodynamic therapy for a predetermined time to perform photodynamic therapy. The photosensitizer accumulated in the cancer cells is photoexcited by the light in the wavelength band for photodynamic therapy to generate active oxygen, and the cancer cells are destroyed and necrotic. The time required for one photodynamic treatment varies depending on the location, spread, etc. of the cancer cells, but is suitably about ten minutes to several tens of minutes.
At this time, as in the case of observation and photodynamic diagnosis, the doctor operates the output adjustment dial 13a as necessary to change the intensity of the light beam emitted by the light source 12, thereby destroying the cancer cells. The degree can be adjusted. The intensity of the light beam applied to the cancer cells is, for example, about 150 mW / c.
m ² is suitable. Then, several days after the end of one photodynamic treatment, the photodynamic treatment is performed again, and the process is repeated until all the cancer cells are necrotic.

As described above, by using the above-described light beam device 10, a relatively inexpensive light source 12 can be used, so that a photodynamic diagnosis and / or a light beam can be performed without using a large and expensive laser generator. Mechanical treatment can be performed. In addition, an optical filter 21 for photodynamic diagnosis, which transmits light in an optimal wavelength band according to the photosensitizer administered in advance, is inserted into the optical path 12a, and this light is irradiated on the lesion to irradiate the cancer cells with light. The optical filter 22 for the photodynamic treatment can be dynamically diagnosed, and the optical filter 22 for the optical path 12a can be used.
The cancer cells can be irradiated with light in a wavelength band for photodynamic therapy to perform photodynamic therapy.

That is, by exchanging the optical filters 21 and 22 in one photodynamic diagnosis / treatment light device 10, it can be used also as a photodynamic diagnosis light device and a photodynamic treatment light device. be able to. In addition, by exchanging the optical filters 21 and 22 in one photodynamic diagnosis / treatment light device 10, a plurality of types of tumors can be subjected to photodynamic diagnosis and photodynamic treatment.

Another example of the optical means for irradiating a light beam from the light source 12 to the surface will be described with reference to FIG. FIG. 4 is a sectional view of a main part of a light beam device using another example of the optical means. In addition, about the structure substantially equivalent to embodiment mentioned above, the same code | symbol is attached | subjected and detailed description is abbreviate | omitted. The light beam diverged from the concave lens 25 serving as the optical means enters the convex lens 28 serving as the optical means, and is converted into a parallel light beam by the convex lens 28. The convex lens 28 is supported on the main body 11 by a lens barrel.

In this example, even if the distance of the irradiation range 26a from the main body 11 of the light beam device 10 changes, the diameter of the irradiation range 26a does not change because the light beams are parallel. Therefore, the doctor can easily set the irradiation time because the intensity of the light beam does not change even if the patient's lesion is located in the irradiation range 26a at an appropriate position from the main body 11. In the above embodiment, for example, when the distance from the main body 11 increases,
Since the diameter of the irradiation range 26 becomes large and the intensity of the light beam becomes weak, it is necessary to lengthen the irradiation time, but this is not necessary in this example.

In the embodiments shown in FIGS. 1 to 3 and FIG. 4, the optical filters 21 and 22 are
An example in which the optical filter is inserted into and removed from the optical path 12a has been described. Next, a filter switching mechanism capable of automatically switching the optical filters 21 and 22 will be described in detail.

FIG. 5 is a structural view of a main part of the first embodiment of the filter switching mechanism, and FIG. 6 is a sectional view taken along the line BB of FIG. In addition, about the structure substantially equivalent to embodiment mentioned above, the same code | symbol is attached | subjected and overlapping description is avoided. 5 and 6, the filter switching mechanism 40 has a plurality of optical filters mounted on the circumference of a circular switching plate 41. In this example, four through holes are formed in the switching plate 41, and the optical filters 42, 43, and 44 are fixed to the three through holes,
One is a state in which the through hole 45 remains. The other three through-holes include, for example, an optical filter 42 transmitting 300 to 400 nm, an optical filter 43 transmitting 500 to 600 nm, and an optical filter 44 transmitting 600 to 700 nm.
Has been fixed. The switching plate 41 is rotatably supported on a shaft 16 a fixed to the support plate 16, and is rotated by a stepping motor 46 and a timing belt 47 as driving means. The position may be determined at a predetermined position by a position sensor such as a photo interrupter.

The stepping motor 46 has a controller 48
The driving circuit 48a is connected to the controller 48, and an instruction means 49 such as an instruction switch is connected to the control device 48. As described above, the light beam device 10 includes the control device 48, and the filter switching mechanism 40 includes the driving unit 46.
Is configured to be driven based on an output signal of the control device 48 in accordance with an instruction from the instruction means 49.

In the state shown in FIGS. 5 and 6, the light source 12 faces the through-hole 45, and the light in the wide wavelength band of the light source 12 is emitted from the concave lens 25 without passing through the optical filter. In this state, the light beam is a light beam in a wide wavelength band, and the illuminance of the irradiation range 26 can be adjusted by the output variable power supply means 13. Therefore, it is possible to observe the diseased part of the patient while adjusting the illuminance appropriately in detail. .

When performing a photodynamic diagnosis, the indicating means 49
When the instruction signal is input to the control device 48 from the, the drive pulse is supplied from the drive circuit 48a to the stepping motor 46. Then, the rotation of the stepping motor 46 is transmitted to the switching plate 41 by the timing belt 47, and is switched from the through hole 45 to the optical filter 42 when a predetermined number of pulses are supplied. That is, the switching plate 41 is rotated, and for example, 300 to 400 n corresponding to the photosensitive material for diagnosis.
The mode is switched to the optical filter 42 that transmits m. The light beam emitted from the light source 12 becomes a light beam of a specific wavelength and is emitted from the irradiation window through the concave lens 25. When the patient's lesion is located in the irradiation area 26, the cancer cells in which the photosensitizer has accumulated emit fluorescence, and the doctor can determine the location of the cancer cells,
The size and the like can be accurately diagnosed.

When performing photodynamic therapy, the optical filter corresponding to the photosensitizer for therapy is switched. At this time, similarly to the above, when an instruction signal is input from the instruction means 49 to the control device 48, a drive pulse is supplied from the drive circuit 48a to the stepping motor 46, and the stepping motor 46 rotates and the optical filter 42 To the optical filter 43. The therapeutic photosensitizer is, for example, 500
In the case where the wavelength corresponds to a wavelength in the range of 600 nm, the optical filter 43 is switched to the corresponding one. As a result, a light beam having a specific wavelength is emitted from the concave lens 25, and the photosensitizer accumulated in the cancer cells in the lesion is optically excited. This causes the photosensitizer to generate active oxygen, causing cancer cells to die. Another optical filter 44 transmitting 600-700 nm corresponds to, for example, another photosensitive material.

In the case of this example, when the doctor gives a switching instruction to the filter switching mechanism 40 from the instruction means 49, the switching plate 41 is rotated by the stepping motor 46, and the predetermined optical filters can be easily and simply arranged in an arbitrary order. It can be switched in a short time. Therefore, there is no need to manually switch the optical filter, and observation, photodynamic diagnosis, and photodynamic treatment can be performed efficiently, and the burden on the patient can be greatly reduced. Although the example of the transmission mechanism for rotating the switching plate 41 from the stepping motor 46 by the timing belt 47 has been described, it goes without saying that a transmission mechanism such as a gear train may be used. Further, the present invention is not limited to the stepping motor, but may be changed to a servo motor or the like.

Another embodiment of the filter switching mechanism will be described with reference to FIG. FIG. 7 is a configuration diagram of a main part of another embodiment of the filter switching mechanism. The filter switching mechanism 50 includes a switching plate 51 that slides in the horizontal direction. The switching plate 51 has three stop positions with respect to the position of the light source 12, the center position in the figure is a through hole 52, and the left position is, for example, an optical filter 53 for photodynamic diagnosis. The optical filter 54 for photodynamic treatment is mounted on the right side position.
Is installed. The switching plate can be slid by a motor, a rack and pinion mechanism, or an electromagnetic mechanism such as a solenoid.

Also in this case, when performing detailed observation with the light beam device 10, the through hole 52 of the switching plate 51 is connected to the light source 1
In order to perform photodynamic diagnosis by observing with a light beam of a wide wavelength corresponding to 2 and switching to an optical filter 53, a photosensitizer is photoexcited by a light beam of a specific wavelength to generate fluorescence and diagnose. Optical filter 5 for treatment
Switching to 4, the photosensitizer is photo-excited with a light beam of a specific wavelength to generate active oxygen for treatment. In the case of this example as well, there is an effect that the optical filters can be automatically switched as in the examples of FIGS.

Referring to FIG. 8, another embodiment of the filter switching mechanism will be described. FIG. 8 is a configuration diagram of a main part of still another embodiment of the filter switching mechanism. Filter switching mechanism 6
Numeral 0 designates a plurality of swingably supported switching plates 61 and 62 selectively positioned in the optical path 12a of the light source 12. That is, two switching plates are swingably supported on a shaft 63 fixed to the support plate 16, an optical filter 64 for photodynamic diagnosis is mounted on the first switching plate 61, and a second switching plate is mounted on the second switching plate 61. The switching plate 62 is provided with an optical filter 65 for photodynamic therapy. The switching plates 61 and 62 are configured to swing by a motor (not shown) or a solenoid mechanism.

Also in this example, as in the above-described example, observation is performed without inserting the optical filters 64 and 65, photodynamic diagnosis is performed by inserting the optical filter 64, and the optical filter 6 is inserted.
5 can be inserted to provide photodynamic therapy. In the case of this example, the plurality of optical filters 64 and 65 are connected to the optical path 12a.
Since the wavelengths can be simultaneously positioned inside, the specific wavelength can be set repeatedly. That is, a wavelength band that is transmitted by the plurality of optical filters 64 and 65 can be set such that the short wavelength side is cut by one optical filter 64 and the long wavelength side is cut by the other optical filter 65.

As an example of the variable output power supply means 13,
Although the example of adjusting the voltage with the volume has been shown, the emission frequency of the light source is changed by adjusting the oscillation frequency, or the pulse duty is adjusted to change the light emission brightness of the light source when performing pulse lighting. May be. Also, a configuration may be adopted in which a plurality of optical filters are switched over more than in the above-described example. Further, the instruction means 49 has been described as an example of an instruction switch, but may be automatically operated after a predetermined operation according to an instruction from a personal computer, a microcomputer, or the like.

As optical means, concave mirror 14, concave lens 2
5, the example in which the convex lens 28 is used has been described.
May be changed to form a parallel light beam only by the concave mirror, and irradiate the parallel light beam from the main body 11 of the light beam device 10 with the optical filters 21 and 22 as a specific wavelength band. In this case, since only the concave mirror is used as the optical means, the configuration can be greatly simplified and the cost can be reduced.

The indicating means 49 can be provided not only in the light beam device 10 but also, for example, by providing a switch extended from the light beam device 10 with a cord or by providing a wireless switch to make it easier to switch the optical filter. In this way, the doctor only has to change the indicating means 49 such as an indicating switch at hand, and the optical filter 21 for the photodynamic diagnosis and the optical filter 22 for the photodynamic treatment can be arranged in any order. Since the switching can be performed more easily and in a shorter time, the burden on the patient can be further reduced.

Further, in each of the embodiments described above, the case of the surface irradiation type photodynamic diagnosis / therapy light beam device has been described. Needless to say, the present invention can be similarly applied to the case of only the photodynamic therapy light beam device. In addition, the operation of the surface irradiation type photodynamic diagnosis / treatment light device of the present invention has been described taking the case of skin cancer as an example, but the surface irradiation type photodynamic diagnosis / treatment light device of the present invention is applied. Needless to say, the lesion is not limited to skin cancer. For example, the present invention can be applied to sterilization of lesions on the skin such as acne, spots and freckles on the body surface.

[0046]

As can be understood from the above description, the surface irradiation type photodynamic diagnostic / therapeutic light device of the present invention uses a light source which emits light in a wide wavelength band, and uses an optical filter for photodynamics. Can be selectively inserted into and removed from the optical path depending on the purpose of diagnostic use and photodynamic treatment, and irradiates a light beam in a specific wavelength band onto the surface. There is an effect that it can also be used as a mechanical treatment light beam device. Further, there is an effect that a single light beam device can deal with a plurality of types of tumors.

Further, since a relatively inexpensive ultraviolet lamp, halogen lamp, or the like can be used as a light source, a large and expensive laser light generator is not required in photodynamic diagnosis and photodynamic treatment. This has the effect. Furthermore, since the optical filter exchange means is provided, the photodynamic diagnosis and the photodynamic treatment can be performed continuously in any order, and the burden on the patient can be greatly reduced. There is. Furthermore, since the light intensity adjusting means is provided,
The intensity of the light beam emitted by the light source can be adjusted, and the photodynamic diagnosis and the photodynamic treatment can be performed with the optimum light intensity.

[Brief description of the drawings]

FIG. 1 is a schematic perspective view showing a surface irradiation type photodynamic diagnostic / therapy light beam device and a light irradiation range according to a first embodiment of the present invention.

FIG. 2 is a cross-sectional view showing a configuration of a main part of the surface irradiation type photodynamic diagnosis / therapy light beam device of FIG. 1;

FIG. 3 is an essential part cross-sectional view along a line AA of FIG. 2 with a main body part omitted;

FIG. 4 is a sectional view of a main part of a light beam device using another example of the optical means.

FIG. 5 is a configuration diagram of a main part of a second embodiment of the surface irradiation type photodynamic diagnosis / treatment light device according to the present invention.

FIG. 6 is a sectional view taken along line BB of FIG. 5;

FIG. 7 is a configuration diagram of a main part of a third embodiment of the surface irradiation type photodynamic diagnosis / treatment light device according to the present invention.

FIG. 8 is a main part configuration diagram of a fourth embodiment of a surface irradiation type photodynamic diagnosis / therapy light beam apparatus according to the present invention.

[Explanation of symbols]

DESCRIPTION OF SYMBOLS 10 Surface irradiation type photodynamic diagnostic / therapeutic light beam device 12 Light source 12a Optical path 13 Output variable power supply means 14 Concave mirror (optical means) 20 Filter mounting means 21, 22 Optical filter 23, 24 Support plate 23a, 24a Mounting groove 25 Concave lens ( Optical means) 26, 26a Irradiation range 28 Convex lens (Optical means) 40, 50, 60 Filter switching mechanism 41, 51, 61, 62 Switching plate 42, 43, 44, 53, 54, 64, 65 Optical filter 45, 52 Penetration Hole 46 motor (drive means) 48 control device 49 indicating means

Claims (12)

[Claims] 1. A light source that emits light in a wide wavelength band including visible light, optical means for irradiating light from the light source onto a surface, and a light in a specific wavelength band among the light emitted from the light source. A surface-irradiation type photodynamic diagnostic / therapeutic light beam device comprising: an optical filter that selectively transmits light; and a filter mounting unit that inserts and removes the optical filter into and from the light path of the light source. 2. The optical filter according to claim 1, wherein the optical filter transmits light in a specific wavelength range corresponding to a photosensitizer for photodynamic therapy and / or photodynamic diagnosis. Surface irradiation type photodynamic diagnostic and therapeutic light equipment. 3. The surface irradiation type photodynamic diagnostic / therapeutic light beam device according to claim 1, further comprising an output adjusting means for adjusting an intensity of a light beam emitted by the light source. 4. The light source according to claim 1, wherein the light source is formed by combining one or more of an ultraviolet lamp, a halogen lamp, a metal halide lamp, a xenon lamp, and a white LED. Item 4. A surface irradiation type photodynamic diagnosis / therapy light beam device according to the above item. 5. The light device for surface-illuminated photodynamic diagnosis and treatment according to claim 1, wherein the optical means comprises a concave mirror and a concave lens. 6. The light device for surface-illuminated photodynamic diagnosis and treatment according to claim 1, wherein the optical means comprises a concave mirror, a concave lens, and a convex lens. 7. The surface-illuminated photodynamics according to claim 1, wherein the filter mounting unit includes a support plate having a mounting groove into which the optical filter is inserted. Diagnostic and therapeutic light equipment. 8. The apparatus according to claim 1, wherein said filter mounting means includes a filter switching mechanism for selectively inserting and removing said optical filter into and from an optical path of said light source.
The light beam device for surface irradiation type photodynamic diagnosis and treatment according to any one of claims 1 to 4. 9. The filter switching mechanism includes a switching plate for arranging a plurality of optical filters on a circumference, and selectively rotating one of the plurality of optical filters in the optical path by rotating the switching plate. The surface irradiation type photodynamic diagnosis / treatment light device according to claim 8, wherein the light device is inserted into and removed from the light source. 10. The filter switching mechanism includes a switching plate that horizontally arranges a plurality of optical filters, and slides the switching plate to selectively insert and remove one of the plurality of optical filters into the optical path. The surface irradiation type photodynamic diagnostic / therapeutic light device according to claim 8, wherein: 11. The filter switching mechanism includes a plurality of swingable switching plates for mounting an optical filter, and swings the switching plate to selectively insert and remove the optical filter into the optical path. The surface irradiation type photodynamic diagnosis / treatment light beam device according to claim 8, characterized in that: 12. The light source device includes a control device, the filter switching mechanism includes a driving unit that moves the optical filter, and the driving unit is driven based on an output signal of the control device, and The light device for surface irradiation type photodynamic diagnosis and treatment according to claim 8 or 9, wherein an optical filter is moved, and the optical filter is selectively inserted into and removed from an optical path of the light source.