JP2001501594A - 骨吸収を防止もしくは減少させるためのプロテイナーゼ阻害剤の用途 - Google Patents
骨吸収を防止もしくは減少させるためのプロテイナーゼ阻害剤の用途Info
- Publication number
- JP2001501594A JP2001501594A JP10508510A JP50851098A JP2001501594A JP 2001501594 A JP2001501594 A JP 2001501594A JP 10508510 A JP10508510 A JP 10508510A JP 50851098 A JP50851098 A JP 50851098A JP 2001501594 A JP2001501594 A JP 2001501594A
- Authority
- JP
- Japan
- Prior art keywords
- mmp
- peptide
- osteolytic
- cells
- bone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9615976.9A GB9615976D0 (en) | 1996-07-30 | 1996-07-30 | The use of proteinase inhibitors for the prevention or reduction of bone resorption |
| GB9615976.9 | 1996-07-30 | ||
| PCT/EP1997/004110 WO1998004287A1 (fr) | 1996-07-30 | 1997-07-29 | Utilisation d'inhibiteurs de proteinase pour la prevention ou la reduction de la resorption osseuse |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2001501594A true JP2001501594A (ja) | 2001-02-06 |
Family
ID=10797737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10508510A Pending JP2001501594A (ja) | 1996-07-30 | 1997-07-29 | 骨吸収を防止もしくは減少させるためのプロテイナーゼ阻害剤の用途 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0915709A1 (fr) |
| JP (1) | JP2001501594A (fr) |
| CN (1) | CN1226174A (fr) |
| AU (1) | AU733104B2 (fr) |
| BR (1) | BR9710615A (fr) |
| CA (1) | CA2261567A1 (fr) |
| GB (1) | GB9615976D0 (fr) |
| IL (1) | IL128103A0 (fr) |
| WO (1) | WO1998004287A1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011506614A (ja) * | 2007-12-17 | 2011-03-03 | ダイアックス コーポレーション | Ｍｍｐ−１４結合タンパク質を含む、骨溶解性障害を処置するための組成物および方法 |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6277061B1 (en) | 1998-03-31 | 2001-08-21 | The Research Foundation Of State University Of New York | Method of inhibiting membrane-type matrix metalloproteinase |
| ATE232544T1 (de) * | 1998-12-31 | 2003-02-15 | Aventis Pharma Inc | Selektive inhibitoren des mmp-12 |
| US6352976B1 (en) | 1998-12-31 | 2002-03-05 | Aventis Pharmaceuticals Inc. | Selective inhibitors of MMP-12 |
| CA2370131A1 (fr) * | 1999-04-09 | 2000-10-19 | Steven M. Ruben | Soixante-deux proteines humaines secretees |
| FR2802945A1 (fr) * | 1999-12-28 | 2001-06-29 | Pf Medicament | Nouvelle metalloprotease matricielle mmp-25 homologue de la matrilysine |
| WO2001074380A2 (fr) * | 2000-04-05 | 2001-10-11 | Ipf Pharmaceuticals Gmbh | Medicament contenant un inhibiteur tissulaire des metalloproteinases-2 (timp-2) en tant que substance osteo- anabolisante |
| WO2001088131A1 (fr) * | 2000-05-19 | 2001-11-22 | Fujichemico, Ltd. | Regulation de l'activite de mt1-mmp |
| US7041787B2 (en) | 2000-12-29 | 2006-05-09 | Kimberly-Clark Worldwide, Inc. | Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases |
| US7094754B2 (en) | 2001-08-16 | 2006-08-22 | Kimberly-Clark Worldwide, Inc. | Anti-aging and wound healing compounds |
| US7186693B2 (en) | 2001-08-16 | 2007-03-06 | Kimberly - Clark Worldwide, Inc. | Metalloproteinase inhibitors for wound healing |
| US6906036B2 (en) | 2001-08-16 | 2005-06-14 | Kimberly-Clark Worldwide, Inc. | Anti-aging and wound healing compounds |
| US7071164B2 (en) | 2001-08-16 | 2006-07-04 | Kimberly-Clark Worldwide, Inc. | Anti-cancer and wound healing compounds |
| JP2006500073A (ja) * | 2002-07-18 | 2006-01-05 | インデックス・ファーマシューティカルズ・アクチエボラーグ | Ｍｍｐ−１２関連炎症性障害を治療するためのアンチセンス化合物、方法および組成物 |
| US7148194B2 (en) | 2002-12-30 | 2006-12-12 | Kimberly-Clark Worldwide, Inc. | Method to increase fibronectin |
| US7189700B2 (en) | 2003-06-20 | 2007-03-13 | Kimberly-Clark Worldwide, Inc. | Anti-chrondrosarcoma compounds |
| CA2635588C (fr) | 2005-12-30 | 2015-11-10 | Dyax Corp. | Proteines de liaison a la metalloproteinase |
| EP2262530A4 (fr) * | 2008-03-03 | 2012-12-05 | Dyax Corp | Protéines de liaison à métalloprotéinase 12 |
| WO2013059439A2 (fr) | 2011-10-21 | 2013-04-25 | Dyax Corp. | Polythérapie comprenant une protéine de liaison à la mmp-14 |
| EP2907512A1 (fr) | 2014-02-14 | 2015-08-19 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Inhibiteurs de MMP-12 en tant qu'agents antiviraux |
| KR101576904B1 (ko) * | 2014-07-31 | 2015-12-14 | (주)케어젠 | 파골세포 분화 및 활성 억제능을 갖는 펩타이드 및 이의 용도 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2848232B2 (ja) * | 1993-02-19 | 1999-01-20 | 武田薬品工業株式会社 | アルデヒド誘導体 |
| DE69412466T2 (de) * | 1993-11-30 | 1999-04-29 | Fuji Yakuhin Kogyo K.K., Takaoka, Toyama | Neue metalloprotease und kodierende dna dafür |
-
1996
- 1996-07-30 GB GBGB9615976.9A patent/GB9615976D0/en active Pending
-
1997
- 1997-07-29 IL IL12810397A patent/IL128103A0/xx unknown
- 1997-07-29 EP EP97940041A patent/EP0915709A1/fr not_active Withdrawn
- 1997-07-29 WO PCT/EP1997/004110 patent/WO1998004287A1/fr not_active Application Discontinuation
- 1997-07-29 JP JP10508510A patent/JP2001501594A/ja active Pending
- 1997-07-29 BR BR9710615-1A patent/BR9710615A/pt not_active Application Discontinuation
- 1997-07-29 CA CA002261567A patent/CA2261567A1/fr not_active Abandoned
- 1997-07-29 AU AU42032/97A patent/AU733104B2/en not_active Ceased
- 1997-07-29 CN CN97196863A patent/CN1226174A/zh active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011506614A (ja) * | 2007-12-17 | 2011-03-03 | ダイアックス コーポレーション | Ｍｍｐ−１４結合タンパク質を含む、骨溶解性障害を処置するための組成物および方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1226174A (zh) | 1999-08-18 |
| AU4203297A (en) | 1998-02-20 |
| BR9710615A (pt) | 2000-01-11 |
| WO1998004287A1 (fr) | 1998-02-05 |
| AU733104B2 (en) | 2001-05-10 |
| EP0915709A1 (fr) | 1999-05-19 |
| GB9615976D0 (en) | 1996-09-11 |
| IL128103A0 (en) | 1999-11-30 |
| CA2261567A1 (fr) | 1998-02-05 |
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