JP2002029949A - Oral composition - Google Patents

Abstract

(57) Abstract: A following general formula (1) or _{(2) M n + 2 P} n O 3n + 1 (1) (MPO 3) m (2) ( where, M a is Na or K And n is 2 or more and m is an integer of 3 or more.) And contains acrylic acid or a derivative thereof in addition to one or more of linear or cyclic water-soluble polyphosphates An oral composition comprising a water-insoluble polymer powder synthesized from a polymerizable monomer and / or a polymethyl methacrylate / dimethylpolysiloxane polymer powder. Effect The oral composition according to the present invention can effectively remove stains on tooth surfaces such as stains, plaques and cigarettes by chemical action, and can also clean portions that cannot be reached by a brush, The chemical cleaning effect in the oral cavity can be significantly improved, and the whitening effect of the tooth surface increases.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral composition having a high effect of chemically removing tooth fouling.

[0002]

2. Description of the Related Art
Stains, plaques, food debris attached or deposited on the tooth surface,
Background Art Dirt on tooth surfaces such as cigarette tar is removed by mechanical action of an abrasive compounded in a dentifrice.
The properties required of this abrasive include a high cleaning effect on the tooth surface and a low abrasion property on the tooth surface. In general oral compositions are blended with inorganic powders such as calcium phosphate and calcium carbonate as abrasives, but when using oral compositions containing these abrasives,
It was inevitable that the soft cervix and the like would be worn to some extent.

[0003] For this reason, various proposals have been made as follows to remove dirt on the tooth surface not by a mere mechanical action but by a chemical action, but the effect is not sufficient, and the tooth is not sufficiently effective. At present, the removal of surface dirt is largely dependent on mechanical action. (1) An oral composition containing a specific organic peroxide (US Pat. No. 3,988,433). (2) An oral composition using a combination of a cationic surfactant and malic acid (US Pat. No. 4,183,916). (3) An oral composition containing an ester having an aromatic ring (Japanese Patent Publication No. 48-43869). (4) An oral composition containing a chelating agent having a stability coefficient of Fe> Ca (Japanese Patent Application Laid-Open No. 51-139,939). (5) An oral composition using a combination of a polyphosphate and a polyvalent metal cation (JP-A-52-108029). (6) An oral composition using phytic acid and an organic acid in combination (JP-A-56-18911). (7) tartronic acid, glyceric acid, hydroxy-n-
An oral composition containing butyric acid and dihydroxymalonic acid (JP-A-60-4117). (8) An oral composition comprising a combination of carvone, anethole or 3-octanol and a solvent extract of Astragalus (JP-A-61-286315). (9) An oral composition containing 2-octanol (JP-A-62-151498). (10) An oral composition containing a specific monoterpene (JP-A-62-181212). (11) An oral composition containing an aliphatic ester having a total carbon number of 7 to 11 (JP-A-62-189233). (12) An oral composition containing citric acid, a polyphosphate and a nonionic surfactant (JP-A-7-126131). (13) Oral composition containing polyphosphate, orthophosphate and anionic surfactant (Japanese Patent Application No. Hei 7-18483)
No. 8). (14) An oral composition containing a polyphosphate, an orthophosphate and an amphoteric surfactant (Japanese Patent Application No. 7-184839).
issue). (15) An oral composition containing a sulfosuccinic acid-based surfactant (JP-A-10-17443). (16) An oral composition containing an amino acid-based surfactant (JP-A-10-17444).

Accordingly, an object of the present invention is to provide an oral composition having an excellent effect of removing dirt on the tooth surface by a chemical action, not by a mechanical action.

[0005]

Means for Solving the Problems and Embodiments of the Invention The present inventors have conducted intensive studies in order to achieve the above object, and as a result, have found that one or more water-soluble polyphosphates and acrylic acid or its acrylic acid have been used. Using a water-insoluble polymer powder synthesized from a polymerizable monomer containing a derivative and / or a polymethyl methacrylate / dimethyl polysiloxane polymer powder in combination, more preferably phenylmethyl alcohol, phenylethyl alcohol, Phenylpropanol, phenoxyethanol, phenoxypropanol,
By blending one or more phenoxyisopropanols, the effect of chemically removing stains on the tooth surface is significantly increased, and stains such as stains, plaques and cigarette tars are effectively removed by chemical action. The inventors have found that they can be removed, and have accomplished the present invention.

Hereinafter, the present invention will be described in more detail.
The oral composition of the present invention contains a water-soluble polyphosphate as an essential component. The water-soluble polyphosphates for use in the present invention, the following formula _{(1) M n + 2 P} n O 3n + 1 (1) ( where, M represents a Na or K, an n ≧ 2.) In Indicated are, for example, sodium pyrophosphate and potassium pyrophosphate having a polymerization degree of n = 2, sodium tripolyphosphate and potassium tripolyphosphate having n = 3, sodium tetrapolyphosphate and potassium tetrapolyphosphate having n = 4, and high polymerization degree of methaline. Linear polyphosphates such as sodium silicate and potassium metaphosphate, and the following formula (2) (MPO ₃ ) _m (2) (where M represents Na or K and m ≧ 3) Sodium trimetaphosphate and potassium trimetaphosphate with a degree of polymerization m = 3, sodium tetrametaphosphate and potassium tetrametaphosphate with m = 4, sodium hexametaphosphate with m = 6 Cyclic polyphosphates, such as potassium hexametaphosphate is used.

[0007] These polyphosphates are used alone or in combination of two or more. Among them, linear polyphosphates are preferred.

The amount of the polyphosphate in the oral composition of the present invention is 0.1 to 10% based on the whole composition.
(Mass percentage, the same applies hereinafter), and particularly preferably 1 to 7%. If the amount is less than 0.1%, the effect of addition cannot be obtained. If it exceeds 10%, the taste may be worsened.

The present invention relates to a water-insoluble polymer powder synthesized from a polymerizable monomer containing acrylic acid or a derivative of acrylic acid such as acrylic acid ester in addition to the water-soluble polyphosphate and / or polymethyl methacrylate (polymethyl methacrylate). Less than,
・ Contains dimethylpolysiloxane polymer powder. In this case, the water-insoluble polymer powder synthesized from the polymerizable monomer containing acrylic acid or a derivative thereof may be a homopolymer of acrylic acid or an acrylic acid derivative such as an alkyl ester thereof, or a copolymer thereof, It may be a copolymer of an acid or a derivative thereof and another monomer such as vinyl acetate or styrene,
A graft polymer such as an acrylic acid / fibroin graft copolymer may be used. Specific examples of the copolymer include an alkyl acrylate copolymer, an alkyl acrylate / vinyl acetate copolymer, an alkyl acrylate / styrene copolymer, and an acrylic acid / acrylic amide / ethyl acrylate copolymer. Examples can be given. These can use a commercial item.

The particle size of the water-insoluble powder in the oral composition of the present invention is preferably 300 μm or less, more preferably 1 to 200 μm in the dry state. Even when used in combination with an acid salt, a sufficient stain cleaning effect may not be obtained. On the other hand, if the particle size is too large, the feeling during use may be uncomfortable.

Particularly preferred polymers and their particle sizes are as follows. Polymethyl acrylate (average particle size 20 μm) Acrylic acid / methyl acrylate copolymer (average particle size 10
μm) Methyl acrylate / isopropyl acrylate copolymer (average particle size 25 μm) PMMA / dimethylpolysiloxane polymer (average particle size 2
0 μm)

The amount of the water-insoluble powder in the oral composition of the present invention is 1% or more, preferably 5 to 50%, based on the whole composition. If the amount is less than 1%, a sufficient stain cleaning effect may not be obtained even when used in combination with the polyphosphate of the present invention.

In the present invention, phenylmethyl alcohol,
It is preferable to mix one or more selected from phenylethyl alcohol, phenylpropanol, phenoxyethanol, phenoxypropanol, and phenoxyisopropanol, and phenylethyl alcohol, phenoxyethanol, and phenoxyisopropanol are particularly preferably used.

The compounding amount is preferably 0.1 to 5%,
In particular, 0.1 to 3% is preferable. If the amount is less than 0.1%, a sufficient effect cannot be obtained, and if it exceeds 5%, the taste of the composition may deteriorate.

The oral composition of the present invention can be prepared and applied as dentifrice such as toothpaste and liquid dentifrice, dental cream, dental whitening pack, mouthwash, dental whitening liquid, etc. The product can be blended with ordinary components according to its type. For example, in the case of a dentifrice, an abrasive, a binder, a thickener, a surfactant, a sweetener, a flavor, and the like can be blended in a usual amount.

For example, abrasives include calcium hydrogen phosphate dihydrate, tribasic calcium phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, silicic anhydride, aluminum silicate, insoluble sodium metaphosphate, tertiary phosphorus Magnesium acid, magnesium carbonate,
Calcium sulfate, bentonite, zirconium silicate,
One or more of polymethyl methacrylate, other synthetic resins, and the like may be blended within a range that does not impair the effects of the present invention.

In this case, in the present invention, these abrasives can be blended in an amount smaller than the usual amount, and it is particularly preferable to prepare them in a form that does not contain abrasives such as dental creams and mouth washes.

Examples of the binder include cellulose derivatives such as carrageenan, sodium carboxymethylcellulose, methylcellulose and hydroxyethylcellulose; alginic acid derivatives such as sodium alginate and propylene glycol alginate; gums such as xanthan gum, jeuran gum, tragacanth gum and karaya gum; One or more kinds of synthetic binders such as polyvinyl alcohol, sodium polyacrylate, and carboxyvinyl polymer, and inorganic binders such as silica gel, veegum, and laponite may be blended.

As humectants, glycerin, sorbitol, propylene glycol, polyethylene glycol,
One or more polyhydric alcohols such as xylitol, maltitol and lactitol may be blended.

As the surfactant, an anionic surfactant such as sodium lauryl sulfate, a nonionic surfactant such as decaglyceryl laurate and diethanolamide myristate, and an amphoteric surfactant such as betaine can be blended. .

The fragrance component includes menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, cineol, linalool, ethyl linalool, crocodile, thymol, peppermint oil, spearmint oil, wintergreen oil, T-shaped oil, fragrances such as eucalyptus oil can be blended alone or in combination, saccharin sodium,
Sweetening agents such as stevioside, glycyrrhizin, perillartin, thaumatin and the like can be added.

Further, in the present invention, cationic fungicides such as chlorhexidine, benzethonium chloride, benzalkonium chloride, cetylpyridinium chloride, decanium chloride, phenolic compounds such as triclosan, hinokitiol and biosol, dextranase, mutanase, lysozyme, amylase, protease, lytic enzymes, enzymes such as superoxide dismutase, vitamin E, vitamins such as vitamin B _6, sodium monofluorophosphate, alkali metal monofluorophosphate salts such as potassium monofluorophosphate, Sodium fluoride, fluorides such as stannous fluoride, tranexamic acid, epsilon aminocaproic acid,
One or more known active ingredients such as aluminum chlorohydroxyl allantoin, dihydrocholestanol, glycyrrhizic acids, glycyrrhetinic acid, bisabolol, glycerophosphate, chlorophyll, sodium chloride, and a water-soluble inorganic phosphate compound can be blended.

[0023]

The oral composition according to the present invention is capable of effectively removing stains on tooth surfaces such as stains, plaques, cigarette tars, etc. by chemical action, and also cleaning parts that cannot be reached by the brush. It can significantly improve the chemical cleaning effect in the oral cavity, and increases the whitening effect on the tooth surface.

[0024]

EXAMPLES The present invention will be specifically described below with reference to experimental examples and examples, but the present invention is not limited to the following examples. In the following examples,% indicates mass percentage.

[Experimental Example] A hydroxyapatite disk (HA plate, manufactured by Asahi Optical Co., Ltd., φ7 × 3 mm) was fixed to a mouthpiece and mounted in the mouth (mandibular tongue side) to form a pellicle on the HA plate. I let it. This was placed in a device that alternately dipped in a stain solution and dried in the air, and operated for 24 hours.
Stain was attached to the plate surface. The composition of the stain solution is as follows. Stain solution composition Ferrous chloride n-hydrate 0.05% Instant coffee 0.37% Instant black tea 0.37%

The stained HA plate was immersed in the sample solution shown in Table 1 for 5 minutes, subjected to reciprocal brushing five times, and then stained with a 10% phloxine solution to stain the pellicle, and color difference (Lab coloration). System) was measured. This removal operation (immersion → brushing → color difference measurement) was repeated until the stain was completely removed (until the color difference of the HA plate became equal to that before the stain was attached). The smaller the number of times of brushing, the higher the chemical removal power was evaluated. Table 1 shows the results.

[0027]

[Table 1] 1) The product of the present invention and the comparative product contain, as a common component, silicic anhydride 20.0% sodium carboxymethylcellulose 1.1 carrageenan 0.2 sodium lauryl sulfate 1.5 glycerin 35.0 sodium saccharin 0.15 fragrance 1.0 . 2) ◎: Number of times of brushing less than 10 times ○: Number of times of brushing 10 or more and less than 15 times Δ: Number of times of brushing 15 or more and less than 25 times ×: Number of times of brushing 25 or more

From the results shown in Table 1, it was found that the chemical cleaning power of the stain was specifically enhanced by adding the water-insoluble powder to the system containing the water-soluble polyphosphate.

Example 1 Toothpaste Silicic anhydride 5.0% Polymethyl methacrylate (average particle size 20 μm) 20.0 Titanium oxide 0.5 Sodium carboxymethylcellulose 1.1 Carrageenan 0.2 Sodium lauryl sulfate 0.9 Sorvit 20.0 Xylit 10.0 Propylene glycol 3.0 Methyl paraben 0.05 Saccharin sodium 0.15 Fragrance 1.0 Tetrasodium pyrophosphate 5.0 Phenoxyethanol 1.0 Water Balance 100.0%

Example 2 Toothpaste Precipitable Silica 10.0% Acrylic Acid / Methyl Acrylate Copolymer 20.0 (Average Particle Size 10 μm) Propylene Glycol 3.0 Sorbit 15.0 Xylit 5.0 Sodium Carboxymethyl Cellulose 1.4 Sodium saccharin 0.1 Stevioside 0.1 Potassium glycyrrhizinate 1.0 Sodium lauryl sulfate 1.0 Tranexamic acid 0.05 α-Alumina anhydride 3.0 Colloidal silica 3.0 Methyl paraben 0.05 Fragrance 1.0 Sodium pyrophosphate 3.0 Sodium tripolyphosphate 2.5 Phenoxyethanol 1.0 Water Balance 100.0%

Example 3 Liquid Dentifrice Silicic Anhydride 10.0% PMMA / Dimethyl Polysiloxane Copolymer 15.0 (Average Particle Size 10 μm) 60% Sorbitol Solution 25.0 Glycerin 25.0 Propylene Glycol 5.0 Xanthan gum 0.2 Sodium N-lauroylglutamate 0.5 Sodium lauryl sulfate 0.5 Carrageenan 0.5 Sodium alginate 1.0 Sodium fluoride 0.22 Dextranase (1 million U / g) 0.5 Saccharin sodium 0.1 Fragrance 1.0 Sodium pyrophosphate 4.0 Sodium tripolyphosphate 3.0 Phenoxyethanol 1.0 Water Balance 100.0%

Example 4 Dental Cream Acrylic Acid / Isopropyl Acrylate Copolymer 20.0% (Average Particle Size: 25 μm) Propylene Glycol 3.0 Sorbit 15.0 Xylit 5.0 Sodium Carboxymethyl Cellulose 1.0 Polyacryl Sodium citrate 1.0 Sodium saccharin 0.1 Stevioside 0.1 Potassium glycyrrhizinate 1.0 Sodium lauryl sulfate 1.0 Tranexamic acid 0.05 Methyl paraben 0.05 Perfume 1.0 Sodium pyrophosphate 5.0 Phenoxyethanol 2.0 Water Remaining 100.0% in total

Example 5 Dental cream Polymethyl acrylate (average particle size: 20 μm) 30.0% Propylene glycol 2.5 Carboxymethyl cellulose sodium 1.1 Carrageenan 0.2 Sodium lauryl sulfate 0.7 Lauroyl glycine potassium 0. 5 Sorvit 20.0 Glycerin 10.0 Xylit 5.0 Methyl paraben 0.05 Saccharin sodium 0.15 Fragrance 1.0 Sodium pyrophosphate 3.5 Sodium tripolyphosphate 3.0 Phenoxyethanol 1.0 Water Balance 100.0%

Example 6 Dental Cream Acrylic Acid / Methyl Acrylate Copolymer 20.0% (Average Particle Size: 10 μm) 60% Sorbite Solution 25.0 Xylit 15.0 Propylene Glycol 5.0 Xanthan Gum 0.2 N -Sodium lauroyl glutamate 0.5 Sodium lauryl sulfate 0.5 Carrageenan 0.5 Sodium alginate 1.0 Sodium fluoride 0.22 Dextranase (1 million U / g) 0.5 Saccharin sodium 0.1 Fragrance 1.0 Tripolyline Sodium acid salt 2.0 Sodium pyrophosphate 3.0 Phenylisopropanol 3.0 Water Residual 100.0%

[Example 7] Dental whitening pack Polymethyl acrylate (average particle size 10 μm) 15.0% xylitol 20.0 propylene glycol 2.5 sodium carboxymethylcellulose 2.5 sodium EDTA 2.0 sodium lauryl sulfate 0. 5 Sodium paraoxybenzoate 0.1 Saccharin sodium 0.1 Isopropyl alcohol 1.0 Fragrance 0.8 Tetrasodium pyrophosphate 4.0 Sodium tetrapolyphosphate 1.0 Phenoxyethanol 1.0 Water Residue 100.0%

Example 8 Liquid Toothpaste Acrylic Acid / Methyl Acrylate Copolymer 20.0% (Average Particle Size 10 μm) Ethanol 2.0 Sodium Saccharin 0.05 Sodium Monofluorophosphate 0.05 Dye 0.01 Benzo Sodium acid salt 0.05 Antioxidant 0.01 Fragrance 0.3 Sodium lauryl sulfate 0.3 POE Sodium myristyl sulfate 0.3 Sodium pyrophosphate 4.0 Sodium tetrapolyphosphate 2.0 Phenoxyethanol 1.0 Water Balance 100. 0%

Example 9 Liquid Toothpaste Methyl Acrylate / Isopropyl Acrylate Copolymer 15.0% (Average Particle Size 25 μm) Glycerin 3.0 Ethanol 5.0 Isopropyl Alcohol 2.0 Saccharin Sodium 0.05 Monofluorophosphine Sodium acid salt 0.05 Sodium benzylate 1.5 Dye 0.01 Sodium benzoate 0.05 Antioxidant 0.01 Fragrance 0.3 Sodium lauryl sulfate 0.3 POE Sodium myristyl sulfate 0.3 Sodium pyrophosphate 2.0 Sodium tripolyphosphate 1.0 Phenylisopropanol 1.0 Water Balance 100.0%

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Claims (2)

[Claims] 1. The following general formula (1) or (2): M _{n + 2} P _n O _{3n + 1} (1) (MPO ₃ ) _m (2) (where M represents Na or K, and n represents 2 M is an integer of 3 or more), and is synthesized from a polymerizable monomer containing one or two or more linear or cyclic water-soluble polyphosphates represented by An oral composition comprising a water-insoluble polymer powder and / or a polymethyl methacrylate / dimethylpolysiloxane polymer powder. 2. The oral composition according to claim 1, further comprising one or more selected from phenylmethyl alcohol, phenylethyl alcohol, phenylpropanol, phenoxyethanol, phenoxypropanol, and phenoxyisopropanol. .