JP2002142720A - Nutrition composition - Google Patents

Abstract

(57) [Problem] To provide a nutritional composition that can supply a required amount of selenium and / or copper to elderly people and the like, and that is safe and does not impair properties and flavor. SOLUTION: This is a nutritional composition for enteral nutrition supplementation containing a selenium-containing yeast and / or a copper-containing yeast, and specific examples thereof include a protein of 0 to 100 g / L and a saccharide of 0 to 500 g / L. Selenium-containing yeast 5 mg to 50 g together with 0 to 120 g / L of fat and 0 to 50 g / L of dietary fiber
/ L and / or copper-containing yeast in an amount of 0.05 to 50 g / L and a liquid food having an energy of 90 kcal or more per 100 mL.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a nutritional composition suitable for supplementing selenium and / or copper by an enteral nutritional supplementation method, and more particularly to a nutritional composition required for bedridden and weak elderly people. The present invention relates to a nutritional composition suitable for enterally supplying various nutrients containing copper.

[0002]

2. Description of the Related Art Enteral nutrition is a nutritional supplementation method using an oral nutritional composition or a tube nutritional composition. A typical nutritional composition is a liquid diet. BACKGROUND ART Liquid foods are administered to patients who have difficulty swallowing foods, and recently, are widely used as a means for supplying necessary nutrition to elderly people such as bedridden elderly people. Especially for elderly people,
Nutrition by a liquid diet is important, as only 40% are said to be in PEM (protein and energy undernutrition).

However, since liquid foods are prepared artificially, there is a tendency that there is a shortage of essential trace elements that are harmless and can be absorbed from the digestive tract. Of the trace elements, selenium is Glutathione peroxidase
Of the active center. Since this glutathione peroxidase is an enzyme that reduces hydrogen peroxide and lipid peroxide in cells, selenium is positioned as an important antioxidant in vivo.

It is said that selenium deficiency causes Keshan disease (Keshan disease, a kind of myocardial disorder), Kashin-Beck disease (endemic osteochondroarthritis), and the like. In addition, during long-term tube feeding, shortness of breath during exertion, general malaise, upper limb muscle pain and metabolic acidosis, hyposelenemia were observed,
Intravenous administration of 100 μg / day of selenium improved the symptoms, and patients with neurological disease who had pallor of the nail bed and hyposelenemia dissolved selenite in distilled water, and administered 100 μg x 2 times / day. There is also a report that administration of the drug by tube showed normalization of serum selenium level.

[0005] In normal dietary intake, selenium supplementation is mainly based on selenoamino acids such as selenomethionine and selenocysteine. The intestinal absorption of selenium in humans is quite high, and selenite and selenomethionine are 80 to 90%.
%, Selenocysteine 50-70%. In the 6th Revised Nutritional Requirements for Japanese (Issued by the 1st publisher) (hereinafter simply referred to as the 6th Revised Nutritional Requirements), selenium has been established as an essential nutrient, and its intake standard has been established. 40 μg / day for women over the age of 45 μg for men
Ingestion is recommended. However, when normal dietary intake is impossible at all, deficiency is a concern.

[0006] Among other trace elements, copper is an essential component of many metal enzymes (cytochrome c oxidase, superoxide dismutase, etc.) that play an important role in metabolic processes of living organisms, 95% of the copper in ceruloplasmin is present as ceruloplasmin, which oxidizes ferrous iron to ferric iron and functions as a ferrooxidase to pass on to transferrin, which is essential for iron metabolism during hematopoiesis . Copper deficiency is better known in livestock such as sheep, cattle and chickens than in humans,
Human copper deficiency is not routinely seen. However,
When normal dietary intake is difficult, copper deficiency has been reported in, for example, premature infants with artificial nutrition and patients who receive high-calorie infusions for a long time, and copper deficiency may occur when liquid diets with a low copper content are used for a long time. Have been reported. By the way, in the above-mentioned sixth revised nutrient requirement, the intake standard is set as an essential nutrient for copper,
It is 1.4 mg per day and 1.6 mg for men.

Until now, various liquid foods have been proposed, but inorganic selenium preparations such as selenite as foods,
At present, inorganic copper preparations such as copper sulfate and copper chloride cannot be used by law, so natural food materials having a high selenium content and a high copper content must be added. On the other hand, infectious diseases are feared in elderly frail people with reduced physical function. Influenza, in particular, is less likely to become severe when a healthy person is affected, but may become more complicated with complications when a person, such as an elderly person, has a chronic disease. Many. It has been pointed out that the immunity is reduced as a major cause. Deficiencies of essential trace elements such as zinc, copper, and selenium are considered to induce various impairments in immunity.

[0008] For example, the immunodeficiency due to zinc deficiency includes selective atrophy of the thymus and thymus-dependent lymphoid tissue and the accompanying deficiency of cellular immunity.
In the case of selenium deficiency, a decrease in the number of leukocytes, particularly neutrophils, and a decrease in the bactericidal function lead to a decrease in the activity of glutathione peroxidase of the leukocytes.

In the sixth revised nutrient requirement described above,
Although zinc, copper, and selenium are set as intake standards as essential nutrients, liquid foods are artificially prepared, and therefore tend to lack harmless essential trace elements that can be absorbed from the digestive tract. Until now, various liquid foods have been proposed, but inorganic zinc, copper and selenium preparations as food cannot be used by law at present, so natural food materials with high content of these must be added. .

As foods containing relatively large amounts of selenium, copper and zinc, fish and shellfish, animal guts, eggs, cereals, meats, dairy products, etc. are well known. Negligible. In addition, since liquid foods are usually thick liquids, they should not cause aggregation, sedimentation or the like. In addition, flavor is also an important factor because it is a food.

[0011]

SUMMARY OF THE INVENTION It is a primary object of the present invention to provide selenium deficiency and / or copper deficiency in an amount sufficient to prevent selenium deficiency and / or copper deficiency to elderly people and the like, An object of the present invention is to provide a nutritional composition that is safe and does not impair the properties or flavor. Another object of the present invention is to provide a sufficient amount of selenium / copper / zinc to the elderly and the like to prevent selenium / copper / zinc deficiency, and it is safe and does not impair the properties or flavor. It is to provide a nutritional composition.

[0012]

Means for Solving the Problems The present inventors have intensively studied various food materials as a selenium source and a copper source which can be added to a liquid food, and as a result, yeast containing selenium or copper contained selenium or copper in cells. Since copper was taken in and firmly bound, it was found that there was no decrease in flavor due to selenium or copper, the safety was high, and the dispersibility in a thick liquid food was excellent. The nutritional composition of the present invention has been completed based on such findings and is characterized by containing selenium-containing yeast and / or copper-containing yeast.

[0013] The selenium-containing yeast used in the present invention means a yeast containing at least selenium in the cells.
The copper-containing yeast refers to a yeast containing at least copper in the cells. In addition, the composition of the present invention preferably contains a yeast containing zinc in the cells (zinc-containing yeast) in addition to the above yeast. In particular, it is preferable to use a mixture of selenium-containing yeast, copper-containing yeast, and zinc-containing yeast.

The nutritional composition of the present invention containing the selenium-containing yeast and / or the copper-containing yeast, or the zinc-containing yeast in addition thereto, is suitably used as a liquid food, particularly a highly nutrient and high energy concentrated liquid food. can do. Further, the nutritional composition of the present invention comprises calcium and magnesium in a weight ratio of 2.
It is preferable to contain it at a ratio of 5: 1 to 1: 1. As a result, it is possible to prevent ischemic heart disease, which is common in the elderly.

[0015] The liquid food of the present invention may contain 0-100 protein.
g / L, carbohydrate 0-500 g / L, lipid 0-120 g /
L, in addition to 0-50 g / L of dietary fiber, the following (1) and
It contains one or both of the yeasts described in (2), and has an energy of 90 kcal or more per 100 mL. (1) 5 mg to 50 g / L of selenium-containing yeast (2) 0.05 to 50 g / L of copper-containing yeast Further, the liquid diet of the present invention is a zinc-containing yeast of 0.05 to 50 g / L.
It preferably contains g / L. By ingesting such a liquid diet of the present invention, PEM, selenium deficiency, copper deficiency or selenium
Copper and zinc deficiencies are reliably avoided, and other necessary nutrients and energy can be easily supplied by enteral nutrition. Particularly, when the necessary zinc, copper, and selenium are supplied at one time, it is advantageous in preventing various infectious diseases.

[0016]

BEST MODE FOR CARRYING OUT THE INVENTION A nutritional composition according to one embodiment of the present invention contains a selenium or copper-containing yeast as a selenium source and / or a copper source. The yeast containing selenium and copper is not particularly limited, and various yeasts including edible yeast can be used. For example, Sacc
genus haromyces, genus Torulopsis, genus Mycotorula, Torulaspo
Examples include yeasts belonging to the genus ra, Candida, Rhodotorula, Pichia, and the like.

Specifically, Saccharomyces cervisiae, S
accharomyces uvarum, Saccharomyces rouxii IFO 043
9; Torulopsis utilis, Torulopsis candida IFO 0856;
Mycotorula japonica, Mycotorula lipolytica; Torul
aaspora delbrueckii; Candida sake, Candida tropic
alis; Hansenula anomala IFO 0140, Hansenula suaveo
lens; Saccharomycopsis fibligera IFO 1665, Sacchar
omycopsis lipolyticaATCC 20182; Rhodotorula rubra
IFO 0870; Pichia farinose IFO 0607 and the like.
Particularly preferably, those used as edible yeast,
For example, Saccharomycescerevisiae, Saccharomyces Uvar
um, Saccharomyces rouxii, Saccharomycopsis fiblige
Examples include baker's yeast, beer yeast, wine yeast, sake yeast, alcohol yeast, amazake yeast, miso soy sauce yeast, feed yeast, and feed yeast belonging to ra and the like.

In order to incorporate selenium into these yeasts, the yeasts are suspended in a selenium solution obtained by dissolving a selenite such as sodium selenite in water, and, if necessary, while heating. , Stirring or shaking. After the treatment, the cells are washed and freeze-dried to obtain the desired selenium-containing yeast. The selenium content of the selenium-containing yeast thus obtained varies depending on the treatment conditions, but usually contains about 5 to 7 mg of selenium per 100 g of yeast.
Since selenium taken into the cells does not easily flow out of the cells, it has no metallic taste unique to selenium and is excellent in safety.

In order to incorporate copper into the yeast, the yeast is suspended in a copper solution obtained by dissolving a copper salt such as copper sulfate or copper chloride in water and, if necessary, heated. While
What is necessary is just to stir or shake. After treatment, wash the cells,
Lyophilize to obtain the desired copper-containing yeast. The copper content of the copper-containing yeast thus obtained varies depending on the treatment conditions.
g-300 mg. Since the copper taken into the cells does not readily flow out of the cells, it has no metallic taste unique to copper and is excellent in safety. Both the selenium-containing yeast and the copper-containing yeast in the present invention have a fine average particle diameter of 150 μm or less. For this reason, it is excellent in dispersibility in liquid foods and the like, and does not easily aggregate and precipitate.

The nutritional composition according to the present invention includes both an oral nutritional composition and a tube nutritional composition, and a preferred example is a liquid diet. The content of the selenium-containing yeast in the nutritional composition is 0.1 to 100 μg / selenium as selenium.
100 mL, preferably 1 to 10 μg / 100 mL is good. The selenium content is determined in consideration of the required amount of selenium per day (criterion of intake), dispersion stability, flavor and the like.

The content of the copper-containing yeast in the nutritional composition is 0.01 to 10 mg / 100 mL, preferably 0.1 to 2 mg / 100 mL, as copper. Copper content, like selenium, the required amount of copper per day (intake standard),
Furthermore, it is determined in consideration of dispersion stability, flavor and the like.

The nutritional composition of the present invention may contain a zinc-containing yeast in addition to the selenium-containing yeast and / or the copper-containing yeast. The yeast containing zinc is not particularly limited, and the same yeast as the yeast containing selenium or copper can be used. To incorporate zinc into yeast, zinc sulfate, zinc chloride, zinc citrate, zinc acetate, zinc tartrate,
The yeast may be suspended in a zinc solution obtained by dissolving a zinc salt such as zinc lactate in water, and stirred or shaken while heating as necessary. After the treatment, the cells are washed and freeze-dried to obtain a zinc-containing yeast.

The zinc content of the thus obtained zinc-containing yeast varies depending on the treatment conditions, but usually contains about 200 to 6000 mg of zinc per 100 g of yeast. Since the zinc taken into the cells does not easily flow out of the cells, there is no metallic taste unique to zinc,
Excellent safety. The zinc-containing yeast has a fine average particle diameter of 150 μm or less. Therefore, it is excellent in dispersibility in a liquid food, and does not easily aggregate and settle. The content of zinc-containing yeast in the nutritional composition is 0.1% as zinc.
-10 mg / 100 mL, preferably 0.3-5 mg /
The volume should be 100 mL.

The nutritional composition of the present invention includes both an oral nutritional composition and a tube nutritional composition, and a preferred example is a liquid diet. When utilizing the nutritional composition of the present invention as a liquid diet,
g / L, carbohydrate 0-500 g / L, lipid 0-120 g / L
And 0 to 50 g / L of dietary fiber, and 5 mg to 50 g / L of selenium-containing yeast and / or copper-containing yeast 0.0
Contains 5 to 50 g / L. This may further contain 0.05 to 50 g / L of zinc-containing yeast. Furthermore, iron can be contained at 1 to 100 mg / L.

In any case, the liquid food according to the present invention must not contain protein, carbohydrate and lipid at the same time of 0, and the energy of the liquid food as a whole is 90 kcal or more, preferably 100 kcal or more per 100 mL. The amounts of each are adjusted so that Further, the energy is desirably 230 kcal / 100 mL or less. In addition, iron is ferric pyrophosphate, iron citrate,
It can be added in the form of an iron salt such as iron gluconate.

Examples of the protein include casein or casein salts such as sodium caseinate and calcium caseinate; animal proteins such as chicken egg protein, milk protein and meat protein; vegetable proteins such as soy protein; peptides such as soy peptide; gelatin. And the like. In addition, degradation products or amino acids of these proteins may be used. One type of protein may be used alone, or two or more types may be used in combination. The protein may supply 0-30%, preferably 10-25% of the total energy of the liquid food, and specifically has a content of 0-100 g / L, preferably 30-65 g / L.

Examples of the carbohydrate include maltodextrin, dextrin, powdered candy, monosaccharides such as glucose and fructose, disaccharides such as maltose and lactose, granulated sugar,
Oligosaccharides and the like. One type of saccharide may be used alone, or two or more types may be used in combination. Carbohydrate is 0 to 70% of the total energy of the liquid food, preferably 50 to 70%
%, Specifically, the content is 0 to 500%.
g / L, preferably 100 to 200 g / L.

Examples of the lipids include vegetable oils such as rice bran oil, soybean oil, cottonseed oil, safflower oil, corn oil, rapeseed oil, palm oil, perilla oil, perilla oil, coconut oil, etc .; animal oils such as tallow, fish oil, MCT; Further, medium-chain fatty acid triglycerides and other synthetic triglycerides may be mentioned.
Only one kind may be used, or two or more kinds may be used in combination. The lipid may supply 0-50%, preferably 15-30% of the total energy of the liquid food, and specifically has a content of 0-120 g / L, preferably 15-35 g / L.
It is.

Examples of the dietary fiber include indigestible polysaccharides such as cellulose, lignin, resistant starch, polydextrose, oligosaccharide, and guar gum enzymatic decomposition product. Dietary fiber content is 0-50g
/ L, preferably 0.5 to 45 g / L. In the present invention, in addition to the above components, vitamins, minerals, emulsifiers and the like conventionally added to various liquid foods can be added as required.

As vitamins, for example, vitamin A,
Vitamin B ₁ , Vitamin B ₂ , Vitamin B ₆ , Vitamin B
₁₂ , fat-soluble or water-soluble vitamins such as vitamin C, vitamin D, vitamin E, vitamin K, niacin, folic acid, pantothenic acid, etc., and these may be used alone or in combination of two or more. May be used. The amount of each of the above-mentioned vitamins can be determined, for example, according to the intake amount (intake standard) described in the 70-year-old male daily activity intensity I described in the above-mentioned sixth revised nutritional requirement.

As minerals, for example, calcium,
Examples thereof include iron, sodium, potassium, phosphorus, and magnesium. These may be used alone or in combination of two or more. The content of these minerals is the same as described above in the sixth revised nutrient requirement.
It can be determined according to the intake amount (intake standard) described in the intensity I of the activity activity of the old male.

In this case, calcium and magnesium are particularly mixed at a weight ratio of Ca: Mg = 2.5: 1 to 1: 1 to prevent diseases such as myocardial infarction and ischemic heart disease. It is preferable in doing. If the proportion of magnesium is lower than the above range, it may cause various diseases such as ischemic heart disease.

That is, magnesium has the function of activating the enzyme ATPase which is an energy source in cells. On the other hand, the intracellular calcium pump is ATP
It is activated by ase and works to keep the intracellular calcium concentration low. Therefore, if an appropriate amount of magnesium is also present in vascular smooth muscle, intracellular calcium concentration is kept low, so that spasm of vascular smooth muscle is prevented, and ischemic heart disease can be prevented.
In addition, magnesium deficiency can be a trigger for neurological disorders, mental disorders, arrhythmias and the like. Calcium is required for the prevention of osteoporosis, and its amount is usually about 50%.
Suitably, it is in the range of 0-1000 mg / L.

Examples of the emulsifier include glycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, phospholipid, gum arabic, xanthan gum, tragacanth gum, guar gum, locust bean gum and the like.
In addition to the above components, for example, sodium chloride,
Taste components such as sodium glutamate, citric acid, sodium citrate, fruit juice, and flavors such as coffee flavor, matcha flavor, and milk flavor can be appropriately blended.

The preparation of a liquid food can be carried out according to a conventional method. That is, a liquid food can be produced by weighing each component, putting it in water, mixing well, emulsifying, filling and sealing in a retort pouch, and performing a sterilization treatment. The liquid food obtained in this way not only provides nutrition and energy necessary for the frail elderly, etc.,
Selenium-containing yeast and / or copper-containing yeast excellent in dispersibility, or, in addition to this, containing a zinc-containing yeast, the required amount of selenium, which was difficult in conventional liquid food,
Copper and zinc can be supplied safely and without sacrificing flavor.

The nutritional composition of the present invention is mainly provided in the form of a liquid food, but may be in any of various forms such as powder, solid, paste, etc. obtained by mixing and drying the above-mentioned components. These may be taken directly or, at the time of ingestion, dissolved or dispersed in water or hot water.

[0037]

EXAMPLES Hereinafter, the nutritional composition of the present invention will be described with reference to examples, but the present invention is not limited to the following examples.

Example 1 Each component was weighed according to the basic prescription shown in Table 1, and about 6 parts were weighed.
The amount of sodium caseinate, calcium caseinate, maltodextrin, mineral dispersion, polyglycerin fatty acid ester, oligosaccharide, rice bran oil, rapeseed oil and MCT (previously vitamin D oil are dispersed in pure water at 5 ° C.) And mixed. 390 mg of yeast containing selenium / copper / zinc (trade name "Mix Mineral Yeast" manufactured by LS Corporation) was further added to the mineral dispersion. This product contained 70.58% by weight of zinc-containing yeast (zinc content: 5% as Zn) and 23.58% of copper-containing yeast (copper content: 1% as Cu).
53% by weight and selenium-containing yeast (selenium content: 1% as Se) mixed at a ratio of 5.89% by weight. The above-mentioned amount is in conformity with the intake standard for a 70-year-old man described in the sixth revised nutritional requirement. After mixing each component, the mixture is poured into a homomixer, and the mixture
Rough emulsification was performed at rpm for 20 minutes. Then, the mixture was heated to 60 ° C. and allowed to stand for 10 minutes.
0 kgf / cm ² , 2 passes). About 2
After cooling to 0 ° C. and adding vitamins and fragrances, messing was performed. Cool the filling tank to approx.
The resulting emulsion was charged while stirring at pm. Then, after filling 225 g of the present solution into the pouch from the filling tank, the pouch was sealed while purging with nitrogen, and sterilized at 121 ° C. for 14 minutes to obtain a thick liquid food. The resulting thick liquid food has an energy of 100 kcal per 100 mL. Further, as a result of analyzing the concentrated liquid food, it was found that the average particle diameter was 2.01 μm, the pH was 6.6, and the osmotic pressure was 450 mOsm. This concentrated liquid food had good selenium / copper / zinc contents, emulsion stability, flavor and the like.

Example 2 Each component was weighed according to the basic prescription shown in Table 1, and about 6 parts were weighed.
After the proteins, carbohydrates, lipids, minerals and emulsifiers in the amounts shown in Table 1 were added to pure water at 5 ° C. and mixed, the mixture was poured into a homomixer and roughly emulsified at about 12,000 rpm for 30 minutes. Then, fine emulsification (500 kgf /
cm ² , 2 passes). The obtained emulsion was cooled to about 20 ° C., vitamins and fragrance were added, and then a measuring procedure was performed. The messed-up liquid was transferred to a filling tank, and after filling 226 g of the pouch, the pouch was sealed while purging with nitrogen and sterilized at 123 ° C. for 14 minutes to obtain a thick liquid food. In addition, 580 mg of the same selenium / copper / zinc-containing yeast (trade name “Mix Mineral Yeast” manufactured by LS Corporation) as in Example 1 was added to the mineral. The above-mentioned amount is in conformity with the intake standard for a 70-year-old man described in the sixth revised nutritional requirement. The resulting concentrated liquid food has an energy of 150 kcal per 100 mL. Further, as a result of analyzing the concentrated liquid food, it was found that the pH was 6.62, and the property was a brown white emulsion.
There was a slightly sweet flavor. This concentrated liquid food was prepared in Example 1.
In the same manner as in the above, the selenium / copper / zinc content, the stability of the emulsion, the flavor and the like were good.

Example 3 Dietary fiber (guar gum enzymatic degradation product) was added in the amount shown in Table 1 together with the protein, saccharide, lipid, mineral and emulsifier shown in Table 1, and the minerals were mixed with those in Example 1 The same selenium-copper-zinc-containing yeast (trade name "Mix Mineral East" manufactured by LS Corporation) is 390 m
Except for charging g, a thick liquid food was obtained in the same manner as in Example 2. The above-mentioned amount is in conformity with the intake standard for a 70-year-old man described in the sixth revised nutritional requirement. The resulting thick liquid food has an energy of 100 kcal per 100 mL. Further, as a result of analyzing the concentrated liquid food, it was found to be pH 6.85, a brown white emulsion having a slightly sweet flavor. This concentrated liquid food was excellent in selenium / copper / zinc content, emulsion stability, flavor and the like as in Example 1.

[0041]

[Table 1]

[0042]

According to the present invention, since at least the selenium-containing yeast and / or the copper-containing yeast are contained in the nutritional composition for enteral nutrition, it is safe and deteriorates in properties and flavor. Therefore, there is an effect that selenium and / or copper can be replenished in an amount sufficient for prevention of selenium deficiency and copper deficiency. Furthermore, by containing zinc-containing yeast, it is also effective in preventing zinc deficiency. In the present invention, calcium and magnesium are added in a weight ratio of 2.5: 1 to 1: 1 in addition to zinc.
By containing at a ratio of 1, it is possible to prevent ischemic heart disease, which is common in the elderly. Furthermore, the liquid diet of the present invention containing at least selenium-containing yeast and / or copper-containing yeast can provide bedridden elderly people and the like with nutrients and energy necessary for daily use of selenium, copper, etc. by an enteral nutritional supplementation method. There is an effect that it can be easily supplied.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 35/72 A61K 35/72 A61P 3/12 A61P 3/12 21/00 21/00 25/00 25 / 00 F term (reference) 4B018 MD05 MD06 MD81 ME02 4C086 AA01 HA01 HA03 HA08 MA01 MA02 MA04 NA10 NA11 ZA01 ZA94 ZC21 ZC54 4C087 BC11 MA01 MA02 NA10 NA11 ZA01 ZA94 ZC21 ZC54

Claims (11)

[Claims] 1. A nutritional composition for enteral nutrition, comprising a selenium-containing yeast and / or a copper-containing yeast. 2. The nutritional composition according to claim 1, further comprising a zinc-containing yeast. 3. The nutritional composition according to claim 1, wherein the content of the selenium-containing yeast is 0.1 to 100 μg / 100 mL in terms of selenium. 4. The method according to claim 1, wherein the content of the copper-containing yeast is 0.1% in terms of copper.
The composition according to any one of claims 1 to 3, wherein the composition is 0.01 to 10 mg / 100 mL. 5. The composition according to claim 2, wherein the content of the zinc-containing yeast is 0.1 to 10 mg / 100 mL in terms of zinc. 6. The selenium-containing yeast and the copper-containing yeast,
2. The composition according to claim 1, wherein the average particle size is 150 μm or less. 7. The method according to claim 1, wherein calcium and magnesium are contained in a weight ratio of 2.5: 1 to 1: 1.
The composition according to any one of the above. 8. The composition according to claim 1, comprising 1 to 100 mg / L of iron. 9. Protein 0-100 g / L, carbohydrate 0-5
00 g / L, fat 0-120 g / L, dietary fiber 0-50
g / L and one or both of the yeasts described in (1) and (2) below, and have an energy of 9/100 mL.
Liquid food characterized by being at least 0 kcal. (1) Selenium-containing yeast 5 mg to 50 g / L (2) Copper-containing yeast 0.05 to 50 g / L 10. A zinc-containing yeast of 0.05 to 50 g /
The liquid food according to claim 9, which contains L. 11. The liquid food according to claim 9, further comprising 1 to 100 mg / L of iron.