JP2002226386A - Composition for integument containing plant extract - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for integument having no adverse effect on the skin and the mucosa and excellent antimicrobial activity. SOLUTION: This composition for integument comprises hyaluronic acid besides a plant component having antimicrobial activity and has no adverse effect on the skin and the mucosa and excellent antimicrobial activity.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a skin composition having excellent antibacterial activity. More specifically, the present invention relates to an outer skin composition which has excellent antibacterial activity but is less irritating to the skin and gentle on the skin.

[0002]

2. Description of the Related Art The presence of skin-resident bacteria is indispensable for the skin surface in contact with the external environment to adapt to it and maintain homeostasis. For this reason, the resident bacteria usually do not need to be removed if they do not adversely affect the skin, but for example, skin such as sweat, such as underarms, crotch or vulva or toes, etc. In a part where bacteria are easily propagated due to a large amount of secretions and poor air permeability, it may cause odor, skin inflammation and skin itching such as itching, so that it may be desired to appropriately remove or sterilize the bacteria. Particularly in the case of women, when there are many secretions such as menstrual blood and vaginal discharge during menstruation, even the resident bacteria are liable to cause the above-mentioned odor and skin damage due to their propagation. Also, certain bacteria that cause inflammation and disease to the skin, such as Propionibacterium acnes, which causes acne, Trichophyton, which causes athlete's foot, or Corynebacter, which is present in sweat glands and causes odor.
It is necessary to actively remove or sterilize ium xerosis and the like.

[0003] Bacteria present on the epidermal surface and mucous membrane of the skin tend to be considered dead or washed away from the skin by washing and removing the skin. In fact, bacteria that accumulate on concave surfaces such as wrinkles and wounds on the skin surface cannot be removed by ordinary washing. Therefore, a skin composition containing an antibacterial component has been conventionally marketed. All of these antimicrobial hull compositions have too little emphasis on antimicrobial properties and little attention to the skin, and are not always satisfactory in terms of skin protection and the like. For example, antibacterial components such as benzalkonium chloride, benzethonium chloride, chlorhexidine gluconate, and salicylic acid generally show skin damage at a high concentration, and even at a low concentration, the sebum membrane is destroyed or keratinocytes are produced by continuous use. It elutes interstitial lipids and reduces skin barrier function. As a result, the horny layer moisture-retaining function may be reduced, the moist feeling of the skin may be lost, and even in a delicate part of the skin such as the vulva where the skin is thin, skin damage may even occur.

[0004] For this reason, there has been a demand for a skin composition having excellent antibacterial properties without adversely affecting the skin and mucous membranes.

For this purpose, mucopolysaccharides such as hyaluronic acid, chondroitin sulfate and heparin,
Skin-friendly antibacterial skin agents have been developed in combination with various moisturizing agents such as proteins such as collagen or derivatives thereof, but when a high concentration of antibacterial components is blended to enhance antibacterial activity, such The fact is that the skin is not sufficiently protected by the addition of a moisturizer.

[0006]

DISCLOSURE OF THE INVENTION The present invention has been made in view of such circumstances, and has as its object to provide a composition for an outer skin which has high antibacterial properties and is excellent in protective action on skin and mucous membranes. It is to provide things. Further, the object of the present invention, in its preferred embodiment, even when used in a body part sensitive to irritation, such as the crotch and vulva, does not have adverse effects such as inflammation and roughness on the skin without irritation, An object of the present invention is to provide an antibacterial hull composition that can be suitably used for the delicate site.

[0007]

Means for Solving the Problems The present inventors have conducted intensive studies in order to solve the above-mentioned problems, and as a result, have found that by using a plant component having an antibacterial activity and hyaluronic acid or a salt thereof in combination, the plant component can be obtained. It was found that the antibacterial activity was enhanced. In the first place, the plant component has no or little if any irritation to the skin, so it is suitable as an external preparation, particularly as a component of an external preparation at a delicate site.However, the present inventors have found that the plant component contains hyaluronic acid or a salt thereof. By using in combination, even if the plant component has irritation, the antibacterial activity can be further enhanced while suppressing the irritation, and furthermore, the action of hyaluronic acid or a salt thereof is excellent in moisturizing properties, and is used. It was confirmed that a skin external preparation having both antibacterial properties and skin protective action, which can give a moist feeling to the skin comfortably, could be prepared. The present invention has been completed based on such findings.

That is, the present invention provides the following (1) to (4)
(1) A composition for a hull containing, as essential components, a plant component having antibacterial activity and hyaluronic acid or a salt thereof. (2) A composition for a hull containing a plant component having an antibacterial activity, wherein the composition further contains hyaluronic acid or a salt thereof to enhance the antibacterial activity of the plant component. Composition. (3) The plant components are fennel, oak, grapefruit, sicon, mint, senkyu, sohakuhhi, thyme, hamamelis, hop, peach, rose hip, chamomile, amacha, arnica, aloe, ginkgo, turmeric, emmeiso, ogon, and hypericum ,
(1) or ((1) or (1) which is a component extracted from at least one plant selected from the group consisting of orange, sagebill, gardenia, gin, saishin, achillea millefolium, parsley, perilla, rosemary, sage, tea, lavender and iris. The composition for an outer skin according to 2). (4) The skin composition according to any one of (1) to (3), further comprising at least one component selected from the group consisting of a cleaning component, a preservative component, a deodorant component, and a solubilizing component.

Further, the present invention relates to a method for enhancing the antibacterial activity of a plant component having an antibacterial activity as described below: (5) The above-mentioned method, wherein hyaluronic acid or a salt thereof is used in combination with the plant component having an antibacterial activity. A method for enhancing the antibacterial activity of plant components.

[0010]

BEST MODE FOR CARRYING OUT THE INVENTION The skin composition of the present invention is characterized by containing a plant component having an antibacterial activity and hyaluronic acid or a salt thereof as essential components.

The plant component used in the present invention is not particularly limited as long as it has antibacterial activity. Preferably, it can be used as a component of an external preparation in the cosmetics field, the pharmaceutical field or the quasi-drug field. There are no restrictions, but specific examples include bukuro, carrot, panax ginseng, altea, arnica, aloe (curacao aloe, aloe vera), nettle, fennel, witch hazel (hamamelis), turmeric, koganebana (ogon), kihada (oubak), Hypericum, rice
(Rice), Ibukitranoo, chamomile, kawamogi (Inchinko), kiwi, cucumber, honeysuckle (Kinginka), Clara (Kujin), grape, gardenia, watercress (Netherlands mustard), comfrey (Hypericum),
Saboso, cactus, hawthorn, siocho, perilla, peonies, birch, horsetail, bodaiju, salvia (sage), sembri, senkyu, mulberry,
Soybean, tachi-kosou (thyme), touki, toukinsen, dokudami, jujube (tiso), elderberry,
Parsley, Adlay (Yokuinin), Butch Yaz Bloom, Loofah, Gama (Houhou), Hop, Marronnier, Melissa, Peach, Yukinoshita, Raspberry, Lavender, Vetch, Rose, Neubara (Aigitsu), Rosemary (Mannenrou), Licorice, Cha (Ryokucha, Kocha,
Oolonga), lily, barley (malt root), wheat,
Ashitaba, apricot (Kyonin), oats, corn, mallow (Usubenitachioyaoi), purple (Sicon), pepper, ginger, lettuce, lemon,
Quince, orange, strawberry, safflower, beech, gentian, gentian (ryutan), mint, green mint (spearmint), mint (peppermint),
Skull, Eucalyptus, Usbania oyster, Kumazasa, Usubasaishin, Keirinsaishin, Odorikosou, Burdock, Garlic, Haupimame, Carob, Pine, Ivy, Cornflower, Waremokou (Jiyu), Kobotoru, Shimotsuke, Avocado, Touokabukawa, Touokasobukon , Hijiki, Hibamata, Sea urchin, Matsumo, Mozuku, Ishige, Habanori, Kombumodoki, Fukuronori, Iwahige, Kagomenori, Aname, Sujime, Trolocomb, Kajime, Tsuruarame, Chigaiso,
Brown algae such as Ezoishige, Rapamoku, Hondarawa, Obamoku, Giant Kelp; etc .; Tengusa, Hirakusa, Omikusa, Obakusa, Tosakanori, Kirinsai, Tsunomata, Tochiyaka, Suginori, Shikinori, Kainori, Usubanori, Ushikenori, Okukenori, Okukenori, Okukenori, Asakurinori Red algae such as, mucadenori, matsunori, sasa matsu, funori, ibaranori, ogonori, sponge, darus, egis, egonori, konohanori, himegoke; chlorella, aonori, donariella, chlorococcus, anaauosa, kawanori, marimoshi, marimoshi,
Casanori, Fujujumo, Tamazumi, Hitogusa,
Green algae such as Spirogyna; cyanobacteria such as Spirulina; grapefruit, prune, lime, genoshoko, shiitake mushroom, ononis, tormentilla, yuzu (kijitsu), spinach, hinoki, button (botanpi), obajanohige (bakkumondou), olive, sunflower (sa) Flour), jojoba, macadamia nuts, meduhome, camellia, almond, cacao, sesame, shea, borage (borage), and other plant extracts. The parentheses above indicate the type of the plant,
Indicates another name or crude drug name. Among them, particularly preferred are fennel, oak, grapefruit, sicon, mint, senkyu, sohakuhi, thyme, hamamelis, hop, peach, rose hip, chamomile, amacha, arnica, aloe, ginkgo, turmeric,
It is an extract of the plants of Emmeso, Ogon, Hypericum perforatum, Orange, Artemisia japonica, Gardenia, Kujin, Saishin, Achillea millefolium, Parsley, Perilla, Rosemary, Sage, Cha, Lavender, Iris, Calendula, Malonier, Lemon, Cucumber, More preferably, it is a plant extract of grapefruit, mint, thyme, hamamelis, peach, rose hip, chamomile, aloe, orange, rosemary, sage, cha, lavender, iris, calendula, marronnier, lemon, cucumber. .

[0012] These plant components may be used alone or in any combination of two or more.
Preferably, it is a combination of two or more. Combinations of the plant components include peach and tea, chamomile and aloe, hamamelis and peach, hamamelis and aloe, lemon and aloe, hamamelis and malonnier, hamamelis and mint, hamamelis and rosemary, rosehip and grapefruit, rosehip and Peach, rose hip and aloe, peach and chamomile, peach and grapefruit, peach and aloe, peach and rosemary, rosemary and chamomile, rosemary and mint, rosemary and chamomile, rosemary and hamamelis, rosemary and aloe, Rosemary and raspberry, rosemary and grapefruit, rosemary and marronnier, rosemary and lemon, rosemary and orange, lavender and hamamelis, lavender and grapefruit, lavender and peach Lavender and aloe, lavender and lemon, raspberry and chamomile, hamamelis and marronnier and calendula, cucumber and lemon and aloe, cha and thyme and aloe, cha and thyme and aloe and rosemary, sage and rosemary and lavender, peach and cha Sage, rosemary, lavender, and the like.

The plant component used in the present invention can be prepared, for example, by extracting an antibacterial fraction from the above plant. There are no particular restrictions on the extraction site of the plant, the extraction method, and the like. For example, it is necessary to use the whole plant of the plant or a part of the plant such as roots, stems, stems, bark, sprouts, leaves, flowers, fruits, and seeds. Depending on the method, drying, shredding, crushing, squeezing, boiling or fermentation, etc., and then extracting using a suitable extraction solvent at low temperature or at room temperature to heating can be mentioned. Examples of the extraction solvent include water; lower alcohols such as methyl alcohol, ethyl alcohol, and propyl alcohol; glycerin, propylene glycol,
Liquid polyhydric alcohols such as 1,3-butylene glycol; and the like.
Also, two or more kinds can be used in any combination. When the plant extract is commercially available, the commercially available plant extract can be used simply.

The proportion of the plant component in the hull composition of the present invention is not particularly limited as long as the hull composition of the present invention has an antibacterial activity.
It can be appropriately selected and used from the range of weight%.
It is preferably 0.0001 to 10% by weight, more preferably 0.001 to 5% by weight, and still more preferably 0.01 to 5% by weight.
% By weight (when the plant component is a water-soluble liquid, it is converted into a dry solid content, and when the plant component is an oil, it is converted into an oil component). The composition containing plant components in this range is non-irritating or hypo-irritating while exhibiting or maintaining high antibacterial activity by containing hyaluronic acid or a salt thereof, and has a skin-friendly antibacterial property. Useful as a composition.

In the present invention, as the hyaluronic acid or a salt thereof used in combination with the above plant component, hyaluronic acid or a salt thereof used in the art can be widely used regardless of the origin. Preferably, the content of these components can be confirmed when a confirmation test is carried out in accordance with the “Composition type specifications for each cosmetic variety”. Examples of the salt of hyaluronic acid include alkali metal salts such as sodium and potassium, alkaline earth metal salts such as magnesium and calcium, ammonium salts, and alkanolamine salts such as monoethanolamine. Preferred are alkali metal salts such as sodium salts.

The mixing ratio of hyaluronic acid or a salt thereof in the hull composition of the present invention is not particularly limited as long as the antibacterial activity of the above-mentioned plant component can be enhanced.
It can be appropriately selected and used from the range of 01 to 30% by weight. Considering that a moisturizing effect can be expected when used in combination with a plant component, it is preferably 0.000.
1 to 10% by weight, more preferably 0.001 to 5%
% By weight, more preferably 0.01 to 1% by weight.
The mixing ratio with the above-mentioned plant component is not particularly limited, but from the effect of enhancing antibacterial activity, hyaluronic acid or a salt thereof: plant component = usually 1: 0.0001 to 1: 1000.
0, preferably 1: 0.001-1: 1000, more preferably 1: 0.01-1: 500, and still more preferably 1: 0.1-1: 100.

[0017] In addition to the above-mentioned plant component and hyaluronic acid or a salt thereof, components such as a washing component, a preservative component, a deodorant component or a solubilizing component can be added to the composition for hull of the present invention. These components are generally irritating to the skin and may be a cause of rough skin.
These may be used alone or in any combination of two or more.

As the cleaning component, a surfactant can be preferably mentioned. Here, the surfactant is not particularly limited as long as it is used as a component of an external preparation in the field of pharmaceuticals, quasi-drugs or cosmetics, and may be classified into anionic, cationic, amphoteric and nonionic types. Any surfactant can be used. Examples of the anionic surfactant include soap base, fatty acid soaps such as sodium laurate, sodium palmitate, and coconut oil fatty acid potassium, alkyl ether carboxylate, fatty acid amide ether carboxylate, acyl lactate, and N-acyl glutamate. , N-acylalanine salt, N-acyl-ω-amino acid salt, alkane sulfonate, α-olefin sulfonate, α-sulfofatty acid methyl ester salt, acyl isethionate, alkyl glycidyl ether sulfonate, monolauroyl mono Such as sodium ethanolamide polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, sodium di-2-ethylhexyl sulfosuccinate, and disodium lauryl disodium POE sulfosuccinate; Rusuruhokohaku salt, alkyl sulfoacetate salt, alkylbenzene sulfonates, alkylnaphthalene sulfonates, N- acylmethyltaurine salts, formalin condensation sulfonates, alkyl sulfates, alkyl ether sulfates, alkylaryl ether sulfates,
Fatty acid alkanolamide sulfate, fatty acid monoglyceride sulfate, alkyl phosphate, polyoxyethylene alkyl ether phosphate, alkyl aryl ether phosphate, fatty acid amide ether phosphate, and the like.

Examples of the cationic surfactant include cyclic quaternary ammonium salts, fatty acid amidoamine salts, quaternary ammonium salts, alkyltrialkylene glycol ammonium salts, and alkyl ether ammonium salts.

Examples of the amphoteric surfactant include betaine type such as 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, amidopropyl betaine laurate, betaine lauryldimethylaminoacetate, glycine type, and aminopropionic acid. And carboxylic acid salts such as sulfonic acid type, sulfuric acid type and phosphoric acid type.

Examples of the nonionic surfactant include propylene glycol monofatty acid esters such as propylene glycol monostearate, ethylene glycol monofatty acid esters, monocottonseed oil fatty acid glycerin, glycerin monoerucate, glycerin sesquioleate, glyceryl monostearate, and the like. Glycerin polyglycerin fatty acid ester such as glyceryl malate monostearate, polyglycerin fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, methyl glucoside fatty acid ester, fatty acid ester of polyhydric alcohol such as alkyl polyglucoside, alkyl of polyhydric alcohol Ether, POE alkyl ether, POE alkyl phenyl ether, POE phytosterol, POE cholestanol, POE POE ethers, such as shea oxy Polo pyrene alkyl ethers, POE fatty acid monoesters,
POE glycol difatty acid ester, polyoxyethylene glycerin fatty acid ester, POE sorbitan fatty acid ester, POE sorbitol fatty acid ester, POE
Methyl glucoside fatty acid ester, POE castor oil, P
Examples include OE hydrogenated castor oil, POE animal and vegetable oils, POE alkyl ether fatty acid esters, and ether esters such as POE polyoxypropylene glycol.

Other surfactants include POE alkylamines, POE fatty acid amides, alkyldiethanolamides, alkylamioxides, POE alkyl mercaptans, fluorine surfactants, silicone surfactants, polypeptide derivatives, natural surfactants Agents and the like.

These surfactants may be used alone or in any combination of two or more. Preferably, alkyl phosphate, polyoxyethylene alkyl ether phosphate, laurate, palmitate, coconut oil fatty acid salt, acylmethyltaurine salt,
Amidopropyl betaine, alkyl sulfosuccinate,
N-acylglutamate, propylene glycol monostearate or ethylene glycol monofatty acid ester.

When these cleaning components are used, the ratio of the cleaning components to be incorporated into the composition for skin does not affect the skin or mucous membranes, the foaming and cleaning properties are good, and the hyaluronic acid or From the viewpoint that a high moisturizing effect and a high cleaning effect and an antibacterial effect can be obtained when used in combination with the salt and the plant component, it is usually 0.00.
It is selected and adjusted from the range of 1 to 90% by weight. It is preferably 0.01 to 50% by weight, more preferably 0.01 to 25% by weight, and still more preferably 0.01 to 10% by weight.

The preservative component is not particularly limited as long as it is used as a component of an external preparation in the field of pharmaceuticals, quasi-drugs or cosmetics. For example, phenol,
Phenolic compounds such as chlorcresol, chlorxylenol, propylmethylphenol, resorcinol, orthophenylphenol, paraoxybenzoic acid ester, thymol, cresol and parachlorophenol;
Acids or salts thereof such as benzoic acid, sodium benzoate, salicylic acid, sodium salicylate, dehydroacetic acid, sodium dehydroacetate, sorbic acid, potassium sorbate, undecylenic acid monoethanolamide; and trichlorocarbanilide, trifluoromethyldichlorocarba Halides such as nilide and trichlorohydroxydiphenyl ether; quaternary ammonium salts such as benzalkonium chloride, benzethonium chloride, alkyltrimethylammonium chloride, cetylpyridinium chloride, alkylisoquinolinylium bromide and domiphan bromide; alkyldiaminoethyl hydrochloride Amphoteric surfactants such as glycine, laurylaminoethylglycine and sodium lauroylsarcosine; and other compounds such as chlorhexidine hydrochloride and glucuronic acid Lorhexidine, chlorobutanol, photosensitizer, thiram, chloramine T, hinokitiol, phenoxyethanol, ethyl alcohol, 2-methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, germar, Glidant, dawisil, protamine and the like. Preferably, propylmethylphenol, paraoxybenzoate, benzoic acid, sodium benzoate, salicylic acid, thymol, cresol, benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, chlorhexidine hydrochloride, chlorhexidine glucuronate, phenoxyethanol, and the like. Preferred are paraoxybenzoate, benzoic acid, sodium benzoate, salicylic acid, benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, phenoxyethanol and the like. These preservatives may be one or two
More than one species may be used. The amount of the preservative component blended in the composition for hull is preferably 0.001 to 10% by weight,
More preferably, it is 0.01 to 5% by weight, and still more preferably 0.05 to 3% by weight.

The deodorant component is not particularly limited as long as it is used as a component of an external preparation in the field of pharmaceuticals, quasi-drugs or cosmetics. For example, porous powder components such as zinc oxide, magnesium oxide, zeolite, magnesium metasilicate aluminate, and silicic anhydride; flavonoids such as chlorophyll, phytol, and chlorophyll;
Plant components such as extracts and oils extracted from plants such as Japanese gourd (Scaraba serrata), cucumber, sansho, perilla, sycamore, parsley, hamamelis, pine, eucalyptus, bergamot, orange, cedarwood, cinnamon, rose, etc. Apple tannins,
Aldehydes such as formaldehyde, glyoxals, glutaraldehyde, β-ethoxypropionaldehyde; cyclodextrin;

Among them, preferred are zinc oxide, magnesium oxide, zeolite, magnesium aluminate metasilicate, silicic anhydride, tea, chlorophyll,
Owl, salamander, perilla, parsley, hamamelis,
Pine, eucalyptus, bergamot, orange, cedarwood, cinnamon, rose. Further preferred are zinc oxide, magnesium oxide, zeolite, magnesium aluminate metasilicate, silicic anhydride, tea, pentagon, perilla, parsley, hamamelis, eucalyptus, bergamot, orange, cedarwood, cinnamon, rose and the like. These deodorizing components may be used alone or in combination of two or more. The amount of the deodorant component to be mixed in the composition for the outer skin is usually 0.001 to 10% by weight, preferably 0.001 to 5% by weight, more preferably 0.001 to 1% by weight.
% By weight, more preferably 0.01 to 1% by weight.

The solubilizing component is not particularly limited as long as it is used as a component of an external preparation in the field of pharmaceuticals, quasi drugs or cosmetics. For example, lower alcohols such as ethanol, polyhydric alcohols such as glycerin, ethylene glycol and propylene glycol, hydroxylated soybean phospholipids, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene lanolin alcohol, polyoxyethylene castor oil, polyoxyethylene cured Castor oil, polyoxyethylene sterol, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkyl phenyl ether, and the like. Among them, preferred are ethanol, glycerin, ethylene glycol, propylene glycol, hydroxylated soybean phospholipid, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene lanolin alcohol, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, And polyoxyethylene alkyl ethers. One or more of these solubilizing components may be used.
The blending amount of the solubilizing component blended in the composition for outer skin is preferably 0.001 to 30% by weight, and more preferably 0.01 to 10% by weight. More preferably, it is 0.
1 to 5% by weight.

Further, the composition for hulls of the present invention may further contain other antibacterial components in addition to the above-mentioned plant components, provided that the effects of the present invention are not hindered. The antibacterial component is not particularly limited as long as it is used as a component of an external preparation in the field of pharmaceuticals, quasi-drugs, or cosmetics. For example, berberine chloride, benzalkonium chloride, benzethonium chloride, chlorhexidine chloride,
Triclosan, isopropylmethylphenol, triclosan, trichlorocarbanilide, sodium bisulfite, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine, benzoic acid, aluminum benzoate, sodium benzoate, isopropanol, undecylenic acid, undecylene Zinc acid, undecylenic acid monoethanolamide, ethanol, alkyltrimethylammonium chloride, dialkyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, stearoylcholaminoformylmethylpyridinium chloride, cetylpyridinium chloride, lysozyme chloride, alkyldiaminoethylglycine hydrochloride, ortho Phenylphenol, sodium orthophenylphenol, Photosensitizer No. 101, photosensitive No. 201, No. photosensitizer 301, photosensitizing dye No. 401, chlorhexidine gluconate solution, cresol, chloramine T, and chloroxylenol, chloro-cresol, chlorphenesin, chlorobutanol, salicylic acid, sodium salicylate, dipropylene glycol,
Alkisisoquinonium bromide, cetyltrimethylammonium bromide, domiphen bromide, sorbic acid, potassium sorbate, zeolite compounds, thianthol, thymol, dehydroacetic acid, sodium dehydroacetate, paraoxybenzoate, parachlorophenol, paraphenol Zinc sulfonate, halocarban, 4-hydroxy-2-oxobenzoxathiol, hinokitiol, zinc pyrithione, phenylethyl alcohol, phenoxyethanol, phenol, phenoxyisopropanol, 1,3-butylene glycol, propionic acid, sodium propionate, potassium propionate , Propylene glycol, hexachlorophen, hexylene glycol, benzyl alcohol, 1,2-pentanediol, methylchloroisothi Zorinon · Methyl Chiya sled non-liquid, lauryl di aminoethyl glycine sodium solution, lauryl betaine, sodium lauroyl sarcosinate, resorcinol, it can be exemplified antibacterial components such as hinokitiol.

Further, the composition for skin of the present invention may further contain another moisturizing component in addition to the above-mentioned hyaluronic acid or a salt thereof. The moisturizing component is not particularly limited as long as it is used as a component of an external preparation in the field of pharmaceuticals, quasi-drugs, or cosmetics. For example, proteins, amino acids, polyhydric alcohols, saccharides and the like can be mentioned. Specifically, mucopolysaccharides such as chondroitin sulfate, dermatan sulfate, heparan sulfate, heparin and keratan sulfate or salts thereof; proteins such as collagen, elastin, fibronectin, keratin or derivatives thereof, hydrolysates and salts thereof Glycine, alanine, valine, isoleucine, serine, threonine,
Amino acids such as aspartic acid, glutamic acid, asparagine, glutamine, lysine, hydroxylysine, arginine, cysteine, cystine, methionine, phenylalanine, tyrosine, tryptophan, histidine, proline, hydroxyproline, ortinin, citrulline, theanine and derivatives thereof, and derivatives thereof. Salts; or amino acid derivatives such as pyrrolidonecarboxylic acid or salts thereof; sorbitol, erythritol, maltose, maltitol, xylitol, xylose, trehalose,
Polyhydric alcohols or saccharides such as inositol, glucose, mannitol, pentaerythritol, fructose, sucrose and its esters, dextrin and its derivatives, honey and brown sugar extract; mucin, panthenol and its derivatives and their salts; urea, phosphorus Lipids, glycolipids, ceramides and the like.

Among these, preferred are chondroitin sulfate or a salt thereof, a protein selected from collagen, elastin, and keratin or a derivative thereof, a hydrolyzate, a salt thereof, glycine, serine, arginine, glutamine, glutamic acid, Theanine, amino acids selected from proline and salts thereof and derivatives thereof, pyrrolidonecarboxylic acid and salts thereof, sorbitol, erythritol, xylitol, xylose, trehalose, inositol, glucose, mannitol, mucin, panthenol and derivatives and salts thereof, Urea and phospholipids can be mentioned. Further preferred are trehalose, panthenol, phospholipid, urea, ceramide, cysteine, collagen, elastin, pyrrolidonecarboxylic acid and salts thereof, keratin, glycine, serine, arginine and glutamine.

One or more of these moisturizing components may be used. When using, for example, the above-mentioned moisturizing components other than hyaluronic acid or a salt thereof, the compounding amount of these moisturizing components to be added to the composition for skin is preferably 0.001.
10 to 10% by weight, more preferably 0.01 to 5% by weight.

The composition for a hull of the present invention may contain, if necessary, a drug or a pharmaceutical part within a quantitative and qualitative range that does not impair the quality such as appearance stability and viscosity and the effect of the present invention. Various components generally used as external preparations in the field of external products or cosmetics, for example, whitening components, anti-inflammatory agents, anti-aging agents, slimming agents, tightening agents, antioxidants, blood circulation promoters, vitamins, amino acids , Irritation reducer,
An analgesic, a cell activator, a thickener, a coloring agent, a dispersant, a pH adjuster, a fragrance and the like can be compounded. These components can be used alone or in combination of two or more.

The hull composition of the present invention comprises the above-mentioned plant component having antibacterial activity and hyaluronic acid or a salt thereof, and if necessary, the above-mentioned components are mixed and mixed, and if necessary, a solvent such as water or the like. By compounding the base of the skin agent used, solid, paste, mousse, gel, powder, solution, solubilization, emulsification, powder dispersion, multilayer, sheet , Aerosols, which can be manufactured by conventional methods in the art.

The composition for the hull of the present invention usually has a pH of 3.5.
It is only necessary to have a liquid property of ~ 9.5, but p
From the viewpoint of not disturbing the H balance and not stimulating the skin, preferably pH 4 to 8, more preferably pH
It is preferably from 4.5 to 7 slightly acidic to neutral.

The composition for the outer skin of the present invention is, for example, a hair wash such as a shampoo; a rinse, a hair treatment, a hair cream, a hair spray, a hair tonic, a hair styling, a hair growth /
Hair cosmetics such as hair nourishes; makeup cosmetics such as foundation, white powder, lipstick, mascara, eyeshadow, eyeliner, eyebrows and nail polish; basic cosmetics such as emulsions, creams, lotions, oils and bags; And cleansing agents such as body cleansing agents; axillary deodorants, athlete's foot treatments, antipruritics, wound healing agents, wipes, detergents, antiphlogistic analgesics, acne treatments, hemorrhoid treatment agents, disinfectants, etc. Various external preparations belonging to the field of cosmetics, external medicines or quasi-drugs can be used. There is no particular limitation on the dosage form, depending on the product, solid form,
Paste, mousse, gel, powder, solution, solubilization, emulsification, powder dispersion, multilayer, sheet, aerosol can be used.

The present invention also relates to a method for enhancing the antibacterial activity of the above plant component, which comprises combining hyaluronic acid or a salt thereof with a plant component having an antibacterial activity. Here, the combination means that the plant component and the hyaluronic acid or a salt thereof coexist in the same system and do not take any specific coexistence state such as dissolution, dispersion and suspension. In such a coexistence state, a plant component having an antibacterial activity is usually mixed with hyaluronic acid or a salt thereof, or a hyaluronic acid or a salt thereof is added and blended into a composition containing a plant component having an antibacterial activity. Can be prepared. As for the combination ratio of the plant component having the antibacterial activity and the hyaluronic acid or a salt thereof, the description regarding the composition for the outer coat of the present invention described above can be applied mutatis mutandis.

Here, the composition containing a plant component having an antibacterial activity preferably includes cosmetics as described above,
A wide variety of dermatological compositions in the field of pharmaceuticals or quasi-drugs can be mentioned. The composition is, as a component other than the plant component, a cleaning component, a preservative component, a deodorant component, a solubilizing component, an antibacterial component other than the plant component, a humectant other than hyaluronic acid or a salt thereof, and other effects of the present invention. Whitening ingredients, anti-inflammatory agents, anti-aging agents, slimming agents, tightening agents, antioxidants, blood circulation enhancers, vitamins, amino acids, stimulants, analgesics, cell activators, thickeners as long as they do not interfere Agents, colorants, dispersants, humectants, preservatives, pH adjusters,
It may contain a fragrance or the like.

[0039]

EXAMPLES The present invention will be described below based on Examples and Experimental Examples.
Although described in more detail, the present invention is limited to these Examples and the like.
It is not specified. In addition,%
Means weight percent unless otherwise specified
You. In the following formula, all of the plant components
Those that conformed to the "Specifications for each type of compound" were used. Example 1 Facial cleansing detergent <Formulation 1> Potassium N-acyl-L-glutamate 10.0 (%) Sodium polyoxyethylene alkyl ether sulfate 5.0 Coconut oil fatty acid amidopropyl betaine solution 10.0 Sodium hyaluronate 0.03 Rose hip Extract 0.01 Lavender oil 0.03Purified water qs Total 100.00%.

Example 2 Body Wash <Formulation 2> Coconut oil fatty acid potassium 20.0 (%) Coconut oil fatty acid imidazolinium betaine 10.0 Coconut oil fatty acid diethanolamide 3.0 Sodium hyaluronate 0.002 Rose hip extract 0.01 sage oil 0.008 purified water qs total 100.00%.

Example 3 Hair Wash <Formulation 3> Sodium acylmethyltaurine 20.0 (%) Sodium polyoxyethylene alkyl ether sulfate 5.0 Coconut oil fatty acid hydrolyzed collagen potassium solution 2.0 Cetyltrimethylammonium chloride 0 .5 sodium hyaluronate 0.01 mentha piperita extract 3.0 purified water q.s. total 100.00%.

Example 4 Systemic detergent <Formulation 4> Sodium acylmethyltaurine 20.0 (%) Sodium polyoxyethylene alkyl ether sulfate 5.0 Coconut oil fatty acid hydrolyzed collagen potassium solution 2.0 Sodium hyaluronate 0007 aloe extract 0.01 rosehip extract 0.01 purified water qs total 100.00%.

Example 5 Whole body detergent <Formulation 5> N-coconut fatty acid acyl-L triethanolamine glutamate 15.0 (%) Coconut oil fatty acid hydrolyzed collagen potassium solution 2.0 Sodium hyaluronate 0.01 Rose rosemary oil 0.008 sage oil 0.006 lavender oil 0.001 purified water qs total 100.00%.

Example 6 Cosmetic <Formulation 6> 1,3-butylene glycol 8.0 (%) Polyoxyethylene hydrogenated castor oil 0.1 Sodium hyaluronate 0.4 Rosemary oil 0.015 Sage oil 0.01 lavender oil 0.01 Chaekisu 0.005 methylparaben 0.02 cetylpyridinium chloride 0.05 purified water q.s. total 100.00%.

Example 7 Agent for Hull <Formulation 7> 1,3-butylene glycol 8.0 (%) Polyoxyethylene sorbitan fatty acid ester 1.0 Sodium hyaluronate 0.04 Peach leaf extract 0.01 Hamamelis extract 0.0 01 lavender oil 0.01 Chaekisu 0.01 isopropylmethylphenol 0.05 carboxyvinyl polymer 0.5 triethanolamine 0.3 purified water q.s. total 100.00%.

Example 8 Acne lotion <Formulation 8> Ethanol 15.0 (%) 1,3-butylene glycol 3.0 Sodium hyaluronate 0.02 Aloe extract 0.5 Hamamelis extract 0.1 Lavender oil 0.01 Cha extract 0.008 isopropylmethylphenol 0.1 menthol 0.01 purified water q.s. total 100.00%.

Examples 5 and 6, Comparative Examples 1 to 4

[0048]

[Table 1]

EXPERIMENTAL EXAMPLE 1 Antibacterial Activity Using the compositions for hulls prepared in Examples 1 to 6 and Comparative Examples 1 to 4, the fingers of a specialized panel (five women) were washed, and the antibacterial activity of each composition was evaluated. The effect was evaluated. The washing method was carried out by washing with 1 g of each washing composition for 2 minutes and then washing with water. The antibacterial test was performed using the agar stamp method. After culturing the bacteria collected before and after washing at 30 ° C. for 2 days, the state of the colonies was observed to check the increase / decrease of the bacteria, and the antibacterial action of each composition was evaluated from this. .

<Evaluation Criteria> A: 1 to 10 colonies The number of bacteria was significantly reduced by wiping (application). : 10: 10 to 30 colonies The number of bacteria was significantly reduced by wiping (application). Δ: 30 to 100 colonies The number of bacteria was slightly reduced by wiping (application). ×: 100 or more colonies The number of bacteria hardly decreased by wiping (application). Table 2 shows the results.

[0051]

[Table 2]

As can be seen from the results, Examples 1 to 6 in which hyaluronic acid and plant components were combined and combined were used.
The cleaning composition of Comparative Example 1 had an enhanced antibacterial action as compared with the cleaning composition of Comparative Example 1 in which only the plant component was blended. The enhanced antibacterial activity was almost as high as the antibacterial activity exhibited by the cleaning compositions of Comparative Examples 3 and 4 containing benzalkonium chloride, which is a strong antibacterial component. From these results, it is understood that a composition containing both a plant component and hyaluronic acid or a salt thereof is useful as an antibacterial composition having excellent antibacterial activity.

EXPERIMENTAL EXAMPLE 2 Moisturizing Effect Using the compositions for hulls (cleaning compositions) prepared in Examples 1 to 6 and Comparative Examples 1 to 4, a delicate zone (pubic area) was prepared on a specialized panel (5 women). After being washed twice a day for 7 days, the condition of the skin was judged comprehensively from the feeling of the skin after use (irritation (skin roughness), refreshing, moist feeling). Specifically, a questionnaire was given on the panel, and a 10-point evaluation was given on a 10-point scale where there was no irritation (skin roughness, roughness) even after use, and there was a moist feeling while refreshing. . Table 3 shows the results.

[0054]

[Table 3]

As can be seen from the results, Examples 1 to 6 using a plant component and a hyaluronic acid salt in combination and Comparative Example 2 containing no antibacterial component were all gentle on the skin.
All panels evaluated that these cleaning compositions did not cause rough skin, did not feel dry or dry after use, and felt moist and refreshing. On the other hand, Comparative Examples 3 and 4 containing benzalkonium chloride, which is an antibacterial component, had poor protective effects on the skin, and felt dryness of the fingers after use, resulting in a questionnaire that they were rough. In particular, although Comparative Example 4 contained hyaluronic acid, there was a questionnaire opinion that the skin protecting effect, particularly the moisturizing effect was not sufficient, and the skin felt dry after use. From this, the cleaning composition of the present invention comprising a combination of a plant component and a hyaluronate is gentle on the skin,
It turns out that it is a composition for skin excellent in usability.

[0056]

EFFECTS OF THE INVENTION The skin composition of the present invention has excellent antibacterial properties because the antibacterial action of plant components is enhanced by the addition of hyaluronic acid or a salt thereof. In addition, the composition for skin of the present invention not only has no adverse effect on the skin but also has an excellent protective effect on the skin and has a moisturizing effect, so that, for example, wiping or cleaning of a site highly sensitive to stimulation such as the vulva. It can be suitably used as a composition for the outer skin suitable for.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 35/78 A61K 35/78 K QTV 7/00 7/00 K J W 7/075 7/075 7/48 7/48 7/50 7/50 31/728 31/728 A61P 17/00 101 A61P 17/00 101 F term (reference) 4C083 AA111 AA112 AC102 AC122 AC352 AC402 AC432 AC442 AC472 AC482 AC542 AC642 AC662 AC692 AC712 AC782 AC792 AC852 AD092 AD331 AD332 AD432 AD552 BB51 CC02 CC04 CC23 CC38 DD23 DD27 EE06 EE13 EE14 4C086 AA01 AA02 EA25 MA02 MA03 MA04 NA05 ZA90 ZC75 4C088 AB02 AB12 AB14 AB26 AB29 AB34 AB38 AB40 AB45 AB52 AC09 AC04 CA04 CA05 CA06 MA07 MA63 NA05 ZA90 ZC75

Claims (5)

[Claims] 1. A composition for a hull containing a plant component having an antibacterial activity and hyaluronic acid or a salt thereof as essential components. 2. A composition for a hull containing a plant component having an antibacterial activity, wherein the composition further comprises hyaluronic acid or a salt thereof to enhance the antibacterial activity of the plant component. Composition for outer skin. 3. The plant component is fennel, oak, grapefruit, sicon, mint, senkyu, soyakuh, thyme, hamamelis, hop, peach,
Rose hip, chamomile, amateur, arnica, aloe, ginkgo, turmeric, emmeso, ogon, hypericum, orange, valerian mugwort, gardenia, kujin, saishin, achillea millefolium, parsley, perilla,
The composition for hulls according to claim 1 or 2, which is a component extracted from at least one plant selected from the group consisting of rosemary, sage, tea, lavender, and iris. 4. A cleaning component, a preservative component, a deodorant component,
The composition for a hull according to any one of claims 1 to 3, further comprising at least one component selected from the group consisting of a solubilizing component and a solubilizing component. 5. A method for enhancing the antibacterial activity of a plant component, which comprises combining a plant component having an antibacterial activity with hyaluronic acid or a salt thereof.