JP2003160462A - Functional skin care preparation having barrier function - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a means for making an active ingredient to act on skin without deteriorating the barrier function of the skin. <P>SOLUTION: This skin care preparation is characterized by containing (1) an active ingredient and (2) ceramide and/or a polymer having a pseudo- biological property. The active ingredient includes preferably a whitening agent, an anti-inflammatory, an anti-fungal agent, an anti-wrinkle agent, and a hair tonic. The polymer having the pseudo-biological property includes preferably a polymer containing sugar structures, amino acid structures or phospholipid structures on the side chains of an acrylic polymer or copolymer. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin external preparation such as a cosmetic or a skin external pharmaceutical composition, and more particularly to a skin external seat useful for effectively exerting an effect of an active ingredient.

[0002]

2. Description of the Related Art External preparations for skin have the advantage of being able to be locally administered to a site close to the affected area. Therefore, they are used in the form of cosmetics or external medicine for skin to improve or prevent diseases where the affected area is close to the skin and functional failure. To be done. As an example of success in such a dosage form, an indomethacin external preparation for skin which avoids gastric damage caused by oral administration can be exemplified. While there are such successful cases,
From the characteristics of the skin whose barrier from the outside world is a basic function,
Percutaneous absorption of the active ingredient is accompanied by great difficulties with conventional methods. When such percutaneous absorption is improved by a percutaneous absorption enhancer or the like, the barrier function of the skin may be impaired, and undesired reactions due to the entry of foreign matter may be observed. That is, it has been desired to develop means for causing the active ingredient to act on the skin without impairing the skin barrier function.

On the other hand, it is already known that ceramides and polymers having a pseudo-biological property have the action of improving the skin barrier function of the living body, but this is the action of the active ingredient on the skin. It was never known to have an impact. Further, there is no known external preparation for skin which comprises 1) an active ingredient and 2) a ceramide and / or a polymer having a pseudo-biological property.

[0004]

The present invention has been made under such circumstances, and it is an object of the present invention to provide means for causing an active ingredient to act on the skin without impairing the barrier function of the skin. .

[0005]

In view of such a situation, the present inventors have made earnest research efforts in search of a means for causing an active ingredient to act on the skin without impairing the barrier function of the skin.
By incorporating 1) an active ingredient and 2) a ceramide and / or a polymer having pseudo-biological properties into a skin external preparation,
The inventors have found that the effects of the active ingredient can be exerted without impairing the skin barrier function, and have completed the invention.
That is, the present invention relates to the techniques described below. (1) An external preparation for skin, which comprises 1) an active ingredient and 2) a ceramide and / or a polymer having pseudobiological properties. (2) The external use for the skin according to (1), wherein the active ingredient is one or more selected from whitening agents, anti-inflammatory agents, anti-wrinkle agents, antibacterial agents and hair-growth agents. Agent. (3) The polymer having a pseudo-biological property is characterized in that the side chain of the acrylic polymer or copolymer contains a moiety having a sugar structure, an amino acid structure or a phospholipid structure, (1) or (2) The external preparation for skin according to. (4) 1) One or more than one selected from a whitening agent, an anti-inflammatory agent, an anti-wrinkle agent and a hair-growing agent, and 2) a moiety having a sugar structure, an amino acid structure or a phospholipid structure in the side chain. An external preparation for skin, which comprises an acrylic polymer or copolymer containing the same. (5) characterized by being a cosmetic for people with sensitive skin,
The external preparation for skin according to any one of (1) to (4). Hereinafter, the present invention will be described in more detail.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION (1) Active ingredient which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention comprises 1) an active ingredient and 2) a ceramide and / or a polymer having pseudo-biological properties. It is characterized by containing. Among these, the active ingredient means a component to be blended with the expectation that it will affect the living body in cosmetics or external medicine for skin, and the component used for such purpose in cosmetics or external medicine for skin. So long as it is a cosmetic, for example, arbutin, hydroquinone maltoside, ascorbic acid and / or
Or a salt thereof, a phosphoric acid ester of ascorbic acid and / or a salt thereof, a whitening agent that suppresses the production of melanin such as a glycoside of ascorbic acid and / or a derivative thereof, or reduces the produced melanin, ursolic acid, oleanol Anti-inflammatory agents such as triterpenic acid and its derivatives such as acids, or skin-beautifying agents (anti-wrinkle agents) that exert a beautiful skin effect like vitamin A group, glycyrrhizin and / or its salt, glycyrrhetin and / or its salt, etc. Examples of such agents include skin external medicines such as estradiol, estrogen such as estriol, progestogens such as progesterone and norethisterone, hydrocortisone, triamcinolone, steroids such as adrenocortical hormones such as betamethasone, indomethacin, ketoprofen, Ketotife , Suprofen, diclofenac, a nonsteroidal anti-inflammatory agents such as fenbufen, diphenhydramine such, antihistamines such as chlorpheniramine maleate, terbinafine, butenafine, and antifungal agents such as bifonazole preferred examples. Among these, particularly preferable ones are a whitening agent and an anti-wrinkle agent capable of exhibiting the effect sufficiently while improving the skin barrier function without impairing the skin barrier function which is the effect of the present invention. Agents or anti-inflammatory agents, more preferred are skin beautifying agents, and those having a hydroquinone skeleton or a phenol skeleton are particularly preferred. These active ingredients may contain only one kind, or may contain two or more kinds in combination. The preferable content of these active ingredients in the external preparation for skin of the present invention depends on the effective concentration of each active ingredient, but is preferably about 0.01 to 10% by weight.

(2) Pseudobiological polymer which is an essential component of the external preparation for skin of the present invention and / or ceramide A polymer having pseudobiological property which is one of the essential components of the external preparation for skin of the present invention , A generic term for a polymer having a side chain having a biological structure or a similar structure constituting a living body, and the biological component includes a sugar chain of a monosaccharide or a polysaccharide, an amino acid or a peptide, and a phospholipid residual chain such as a phosphorylcholine group. Etc. can be preferably exemplified. Such side chains can be attached directly to the polymer substrate or via a difunctional group such as ethylene glycol (oxyethoxy group). As the base polymer, acrylic acid or its ester, methacrylic acid or its ester, vinyl alcohol or its ester, and polymers or copolymers of styrene, propylene, ethylene, butadiene, butene, etc. are preferable. Among them, acrylic acid or its ester, and polymer or copolymer of methacrylic acid or its ester can be preferably exemplified. Such a polymer is obtained by treating acrylic acid or methacrylic acid with a halogenating agent such as thionyl chloride to convert it into an acid halide, and if it is a sugar chain, a sugar having a hydroxyl group protected by an acyl group in the presence of an alkali is a sugar. By reacting with a silver catalyst in the presence of a silver catalyst, a monomer having a sugar chain can be obtained. Further, in the case of an amino acid, condensation of the acid halide in the presence of an alkali causes the amino acid to be bonded as a side chain with an amide bond. Different monomers can be obtained. For phospholipid residues such as phosphorylcholine groups, corinylphosphonic acid is converted to corinylphosphonyl halide with a halogenating agent,
This is reacted with sodium alkoxide of ethylene glycol, etc. to form corinylphosphoryloxyethanol, and after replacing the hydroxyl group of this with sodium, the monomer is obtained by condensing with acrylic acid or methacrylic acid chloride. You can By polymerizing these monomers with acrylic acid and / or its ester, methacrylic acid and / or its ester and the like by a usual method, a polymer having pseudo-biological property can be obtained. The polymer having a pseudo-biological property can be produced in this manner and used, or a part of such a polymer having a pseudo-biological property is already on the market and can be used. Among such commercially available polymers having pseudo-biological properties, preferred are polymethacryloyloxyethoxyphosphorylcholine, "Vital polymer" (manufactured by NOF Corporation), polyglucosylethoxymethacrylic acid, P-GEM.
Preferred examples include AS (manufactured by Nippon Seika Co., Ltd.) and PM lysine (manufactured by Gifu Shellac Co., Ltd.), which is polymethacryloyl lysine.

The ceramide may be used without particular limitation as long as it has a structure in which a fatty acid is bonded to an amide bond to sphingosine or dihydrosphingosine. These ceramides can be obtained by extraction from the brain of a living body or can be produced by reacting sphingosine or dihydrosphingosine with an acid halide of a fatty acid in the presence of an alkali. As the ceramide, a desired one can be produced and used as described above, and many of such ceramides are already on the market, and such a commercially available product can be purchased and used. Of these commercially available products, the particularly preferred one is (2S, 3R) -2.
-Ceramide TIC (manufactured by Takasago International Co., Ltd.), which is octadecanoylaminooctadecane-1,3-diol.

In the external preparation for skin of the present invention, the ceramide and / or the polymer having a pseudo-biological property may contain only one kind, or may contain two or more kinds in combination. The preferred form of such inclusion is a form containing at least a polymer having a sugar chain, and the most preferred form is a polymer having a sugar chain, a polymer having an amino acid residue, a polymer having a phosphorylcholine group, and a ceramide. Is a form containing.
The preferred content of the ceramide and / or the polymer having pseudo-biological property in the external preparation for skin of the present invention is 0.01 to 10% by weight in total with respect to the total amount of the external preparation for skin, and more preferably, It is 0.1 to 5% by weight. This is because if it is too large, the effect of the active ingredient may be impaired, and if it is too small, the barrier function may not be exhibited.

(3) External preparation for skin of the present invention The external preparation for skin of the present invention is a form containing 1) an active ingredient and 2) a ceramide and / or a polymer having a pseudo-biological property, and is administered to the external skin. As long as it is one, it is applied without particular limitation, and cosmetics or skin external medicine can be preferably exemplified. Among these, particularly preferable ones are
Cosmetics. This is because the skin barrier function is a very important factor in cosmetics. The external preparation for skin of the present invention may contain, in addition to the above-mentioned essential components, any components usually used in cosmetics. For example, hydrocarbons such as squalane, liquid paraffin, and solid paraffin, silicones such as dimethicone and femethicone, esters such as jojoba oil and gallow, fatty acids such as stearic acid and oleic acid, behenyl alcohol, cetanol, and oleyl alcohol. Nonionic surfactants such as higher alcohols, triglycerides such as beef tallow and olive oil, sorbitan sesquioleate, polyoxyethylene sorbitan monooleate, polyoxyethylene stearate, anionic surfactants such as sodium lauryl stearate, 4 Cationic surfactants such as secondary alkyl ammonium salts, polyhydric alcohols such as glycerin, 1,3-butanediol, isoprene glycol and 1,2-pentanediol, crystalline cellulose and crosslinked methyl Powders such as polysiloxanes, alkyl acrylate-methacrylic acid copolymers and / or salts thereof, carboxyvinyl polymers and / or salts thereof, such as thickeners, such as xanthan gum and hydroxypropylcellulose can be preferably exemplified. The external preparation for skin of the present invention can be produced by treating these essential components and optional components according to a conventional method. The thus-obtained external preparation for skin of the present invention forms a barrier layer containing an active ingredient on the skin and does not impair the skin barrier function, but rather has a form in which the entire skin including the external preparation rather improves the barrier ability. ,
The active ingredient can be caused to act more reliably, and thus the effectiveness can be improved. Therefore, the external preparation for skin of the present invention can be suitably used even for people with sensitive skin.

[0011]

The present invention will be described in more detail below with reference to examples, but it goes without saying that the present invention is not limited to these examples.

<Examples 1 to 5> According to the formulations shown below, cosmetics (milky lotions) as external preparations for skin of the present invention were prepared. That is, the components a and b were each heated to 80 ° C., the mixture b was gradually added to a and emulsified, the particles were homogenized with a homogenizer, and the mixture was stirred and cooled to obtain an emulsion. Using these emulsions, a use test for 2 weeks was conducted using 22 panelists from 1 group. In the use test, the sample was used twice a day in the morning and evening instead of the normally used cosmetic emulsion, and 24 hours after the last use, the degree of improvement of stains or black and white was evaluated according to the following criteria. I got it evaluated. That is,
Spots and blacks are not noticeable: 10 points, stains and blacks are thin: 7.5 points, stains and blacks are slightly thin: 5 points, no change: 2.5 points, stains and colors Black deteriorated: 0 points, 22 people averaged, average 10-8
Is classified into ⊚, 8 to 5 is classified into ◯, 5 to 3 is classified into Δ, and 3 to 0 is classified into x. At the same time, Controls 1 to 6 lacking both or one of the two, and Comparative Examples 1 to 6 in which a ceramide and / or a polymer having pseudo-biological property is replaced with a normal polymer
3 was also examined in the same manner. The results are shown in Table 1. From this, it can be seen that the cosmetic of the present invention increases the effectiveness of the active ingredient. The unit of numerical values in Table 1 is parts by weight. Isqualane 10 parts by weight Solid paraffin 3 parts by weight Cetanol 2 parts by weight Stearic acid 1 part by weight Glyceryl monostearate 1 part by weight POE (25) monostearate 2 parts by weight Ro-1,3-butanediol 5 parts by weight Glycerin 2 parts by weight Ingredients in Table 1 74 parts by weight * Arbutin in the table is a general name for hydroquinone glucoside

[0013]

[Table 1]

<Example 6> Similar to Examples 1 to 5, the same investigation was performed by changing the active ingredient to dimagnesium ascorbate phosphate. p-GEMA-s, vital polymer, PM
The comparative example 7 in which lysine and ceramide were replaced with water had an evaluation of Δ, whereas this had an evaluation of ⊚, and the same effect was obtained even when the active ingredient was replaced with dimagnesium ascorbate phosphate. I found out that That is, it is understood that the effect of the present invention can be obtained at least over the entire whitening agent. Isqualane 10 parts by weight Solid paraffin 3 parts by weight Cetanol 2 parts by weight Stearic acid 1 part by weight Glyceryl monostearate 1 part by weight POE (25) monostearate 2 parts by weight Ro-1,3-butanediol 5 parts by weight Glycerin 2 parts by weight Water 70.6 parts by weight p-GEMA-s 0.1 parts by weight Vital polymer 0.1 parts by weight PM lysine 0.1 parts by weight Ascorbic acid 2 magnesium phosphate 3 parts by weight

Example 7 A cosmetic (milky lotion) as an external preparation for skin of the present invention was prepared according to the following formulation. That is, the components a and b were each heated to 80 ° C., the mixture b was gradually added to a and emulsified, the particles were homogenized with a homogenizer, and the mixture was stirred and cooled to obtain an emulsion. For this, its anti-inflammatory effect was evaluated using a guinea pig inflammation model. Six guinea pigs per group (male, 300-350g)
After removing the hair from the back, the hair was shaved, and 0.05 ml of a 0.01% sodium lauryl sulfate solution in physiological saline was intradermally injected thereinto to create mild inflammation. 24 hours after intradermal injection, 4
0.05 ml of the emulsion was applied for 8 hours and 72 hours, and the skin reaction was evaluated for 96 hours by the Draize standard. That is, ++: reaction with edema, +: reaction with clear erythema, ±: reaction with unclear erythema, −: no reaction. At the same time, the same evaluation was performed for Control Example 8 in which p-GEMA-s, vital polymer, PM lysine and ceramide were replaced with water. As a result, the cosmetics of the present invention are all-
In contrast to (non-reaction), Control Example 8 was ± (reaction with unclear erythema) in 3 cases, and- (non-reaction) in 3 cases, and the effect-enhancing action of the active ingredient of the present invention was confirmed. It was That is, it became clear that the effect of the present invention does not depend on the kind of effectiveness of the active ingredient. Isqualane 10 parts by weight Solid paraffin 3 parts by weight Cetanol 2 parts by weight Stearic acid 1 part by weight Glyceryl monostearate 1 part by weight POE (25) monostearate 2 parts by weight Ro-1,3-butanediol 5 parts by weight Glycerin 2 parts by weight Water 73.5 parts by weight p-GEMA-s 0.1 parts by weight Vital polymer 0.1 parts by weight PM lysine 0.1 parts by weight Glycyrrhizin dipotassium 0.1 parts by weight

<Example 8> A skin external preparation, which is the external preparation for skin of the present invention, was prepared according to the following formulation. That is, the components a and b were each heated to 80 ° C., the mixture b was gradually added to a and emulsified, the particles were homogenized with a homogenizer, and the mixture was stirred and cooled to obtain an emulsion. It was clarified that this product is effective for persons with atopic dermatitis, which cannot be dealt with by the conventional prednisolone preparation, and the effect of the present invention is applied to all skin external preparations. This also proves that the effect of the present invention is partly due to the enhancement of the skin barrier function. Isqualane 10 parts by weight Solid paraffin 3 parts by weight Cetanol 2 parts by weight Stearic acid 1 part by weight Glyceryl monostearate 1 part by weight POE (25) monostearate 2 parts by weight Ro-1,3-butanediol 5 parts by weight Glycerin 2 parts by weight Water 72.6 parts by weight p-GEMA-s 0.1 parts by weight Vital polymer 0.1 parts by weight PM lysine 0.1 parts by weight Prednisolone 1 part by weight

<Example 9> A skin external preparation, which is the external preparation for skin of the present invention, was prepared according to the following formulation. That is, the components a and b were each heated to 80 ° C., the mixture b was gradually added to a and emulsified, the particles were homogenized with a homogenizer, and the mixture was stirred and cooled to obtain an emulsion. This product showed an effect of improving bilan and treating tinea tinea with respect to interdigital finger tinea associated with bilan. Isqualane 10 parts by weight Solid paraffin 3 parts by weight Cetanol 2 parts by weight Stearic acid 1 part by weight Glyceryl monostearate 1 part by weight POE (25) monostearate 2 parts by weight Ro-1,3-butanediol 5 parts by weight Glycerin 2 parts by weight Water 72.6 parts by weight p-GEMA-s 0.1 parts by weight Vital polymer 0.1 parts by weight PM lysine 0.1 parts by weight Terbinafine 1 part by weight

[0018]

According to the present invention, it is possible to provide a means for causing an active ingredient to act on the skin without impairing the barrier function of the skin.

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[Submission date] March 12, 2003 (2003.3.1)
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[Claims]

4. The external preparation for skin according to any one of claims 1 to 3 , which is a cosmetic for humans with sensitive skin.

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[0001]

TECHNICAL FIELD The present invention relates to a skin external preparation such as a cosmetic and a skin external pharmaceutical composition, and more specifically to a skin external preparation useful for effectively exhibiting the effects of active ingredients. > Regarding.

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[0005]

[ Means for Solving the Problems ] In view of such a situation,
As a result of intensive research efforts, the inventors of the present invention have sought for a means for acting an active ingredient on the skin without impairing the barrier function of the skin, and as a result, 1) act on the skin to affect the living body.
By containing an active ingredient expected to give a sound and 2) a ceramide and / or a polymer having pseudo-biological properties in a skin external preparation, the effect of the active ingredient can be exerted without impairing the skin barrier function. And found the invention. That is, the present invention relates to the techniques described below. (1) 1) Affects the living body by acting on the skin
2) Ceramide and / or active ingredient expected to be given
Alternatively, a skin external preparation characterized by containing a polymer having a pseudo biological property. (2) The external use for the skin according to (1), wherein the active ingredient is one or more selected from whitening agents, anti-inflammatory agents, anti-wrinkle agents, antibacterial agents and hair-growth agents. Agent. (3) The polymer having a pseudo-biological property is characterized in that the side chain of the acrylic polymer or copolymer contains a moiety having a sugar structure, an amino acid structure or a phospholipid structure, (1) or (2) The external preparation for skin according to. ( 4 ) It is a cosmetic for people with sensitive skin,
(1)-( 3 ) The external preparation for skin according to any one of items. Hereinafter, the present invention will be described in more detail.

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[0006]

BEST MODE FOR CARRYING OUT THE INVENTION (1) Active ingredient which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is 1) acted on the skin.
It is characterized by containing an active ingredient which is expected to affect the living body and 2) a ceramide and / or a polymer having a pseudo-biological property. Of these, it acts on the skin
The effective ingredient that is expected to have an effect on the living body by means of the above means an ingredient that is blended with the expectation that it will have an effect on the living body in cosmetics or external medicine for skin. There is no particular limitation as long as it is a component used for such a purpose in a cosmetic or a skin external medicine, and for example, in the case of a cosmetic, for example, arbutin, hydroquinone maltoside, ascorbic acid and / or its salt, alcorbin. A whitening agent that suppresses the production of melanin such as a phosphoric acid ester and / or salt thereof, a glycoside of ascorbic acid and / or a derivative thereof, or reduces the formed melanin, and triterpene acid such as ursolic acid and oleanolic acid Skin-beautifying agents (anti-wrinkle agents), glycyrrhizin and / or salts thereof that exhibit skin-beautifying effects such as or derivatives thereof or vitamin A group,
An anti-inflammatory agent or the like that relieves inflammation such as glycyrrhetin and / or its salt can be exemplified, and if it is a skin external medicine,
Estrogens such as estradiol and estriol, progestogens such as progesterone and norethisterone, steroids such as hydrocortisone, triamcinolone and corticosteroids such as betamethasone, indomethacin, ketoprofen, ketotifen,
Non-steroidal anti-inflammatory agents such as suprofen, diclofenac and fenbufen, antihistamines such as diphenhydramines, chlorpheniramine maleate and the like, antifungal agents such as terbinafine, butenafine and bifonazole can be preferably exemplified. Among these, particularly preferable ones are a whitening agent and an anti-wrinkle agent capable of exhibiting the effect sufficiently while improving the skin barrier function without impairing the skin barrier function which is the effect of the present invention. Agents or anti-inflammatory agents, more preferred are skin beautifying agents, and those having a hydroquinone skeleton or a phenol skeleton are particularly preferred. These active ingredients may contain only one kind, or may contain two or more kinds in combination. The preferable content of these active ingredients in the external preparation for skin of the present invention depends on the effective concentration of each active ingredient, but is generally 0.01 to 10
Weight percent is preferred.

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[0010] (3) external preparation for skin external preparation for skin of the Invention The present invention is due to be applied to 1) the skin
And active ingredients that are expected to affect the living body 2)
As long as it is a form containing a ceramide and / or a polymer having a pseudo-biological property and is to be administered externally to the skin, it can be applied without particular limitation, and cosmetics or skin external medicine can be preferably exemplified. . Of these, cosmetics are particularly preferable. This is because the skin barrier function is a very important factor in cosmetics. The external preparation for skin of the present invention may contain, in addition to the above-mentioned essential components, any components usually used in cosmetics. For example, hydrocarbons such as squalane, liquid paraffin, and solid paraffin, silicones such as dimethicone and femethicone, esters such as jojoba oil and gallow, fatty acids such as stearic acid and oleic acid, behenyl alcohol, cetanol, and oleyl alcohol. Nonionic surfactants such as higher alcohols, triglycerides such as beef tallow and olive oil, sorbitan sesquioleate, polyoxyethylene sorbitan monooleate, polyoxyethylene stearate, anionic surfactants such as sodium lauryl stearate, 4 Cationic surfactants such as primary alkyl ammonium salts, glycerin, 1,3-butanediol, isoprene glycol,
Polyhydric alcohols such as 1,2-pentanediol, powders such as crystalline cellulose and cross-linked methylpolysiloxane, acrylic acid / alkyl methacrylate copolymers and / or salts thereof, carboxyvinyl polymers and / or salts thereof, xanthan gum Preferable examples include thickeners such as and hydroxypropyl cellulose. The external preparation for skin of the present invention can be produced by treating these essential components and optional components according to a conventional method. The thus-obtained external preparation for skin of the present invention forms a barrier layer containing an active ingredient on the skin and does not impair the skin barrier function, but rather has a form in which the entire skin including the external preparation rather improves the barrier ability. The active ingredient can be caused to act more reliably, and thus the effectiveness can be improved. Therefore, the external preparation for skin of the present invention can be suitably used even for people with sensitive skin.

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[0018]

INDUSTRIAL APPLICABILITY According to the present invention, a living body is affected by acting on the skin without impairing the barrier function of the skin.
Means can be provided for acting on the skin with the active ingredient expected to be given .

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 7/00 A61K 7/00 Z 7/06 7/06 45/00 45/00 47/16 47/16 47/30 47/30 47/32 47/32 A61P 17/00 A61P 17/00 17/14 17/14 29/00 29/00 31/04 31/04 F term (reference) 4C076 BB31 CC04 CC18 CC31 DD52A EE02A 4C083 AC012 AC022 AC072 AC122 AC242 AC402 AC422 AC582 AC641 AC642 AD091 AD092 AD352 AD392 AD432 AD642 BB48 BB51 EE12 EE16 4C084 AA17 MA63 NA14 ZA891 ZB221

Claims (5)

[Claims] 1. An external preparation for skin, which comprises 1) an active ingredient and 2) a ceramide and / or a polymer having a pseudo-biological property. 2. The method according to claim 1, wherein the active ingredient is one or more selected from whitening agents, anti-inflammatory agents, anti-wrinkle agents, antibacterial agents and hair growth agents. External skin preparation. 3. The polymer having a pseudo-biological property is one in which a side chain of an acrylic polymer or copolymer contains a moiety having a sugar structure, an amino acid structure or a phospholipid structure, The external preparation for skin according to. 4. A 1) or 2 or more kinds selected from 1) a whitening agent, an anti-inflammatory agent, an anti-wrinkle agent and a hair-growing agent, and 2) a side chain having a sugar structure, an amino acid structure or a phospholipid structure. An external preparation for skin, which comprises an acrylic polymer or a copolymer containing a portion. 5. The external preparation for skin according to any one of claims 1 to 4, which is a cosmetic for people with sensitive skin.