JP2003275286A - Composition for disinfection of contact lens and disinfection method using the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a composition for the disinfection of contact lenses and a method of disinfecting the contact lenses handily, efficiently and safely by using the same. <P>SOLUTION: The composition for the disinfection of contact lenses comprises (A) a non-liquid type preparation for disinfection consisting of an iodine based disinfectant and (B) a neutral rinsing liquid agent containing a reducing agent. The contact lens is immersed into a mixed solution in which (A) the preparation for disinfection is mixed into (B) the neutral rinsing liquid agent to be dissolved or the contact lens is immersed into (B) the neutral rinsing liquid agent and then, (A) the preparation for disinfection is mixed into the liquid solution to be dissolved. Thereafter, the aqueous solution, colored yellow or blown by iodine, is checked to see that it is turned colorless and then, the contact lens is taken out of the aqueous solution. This accomplishes the disinfection and neutralization of the contact lenses more handily and in safety. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a composition for disinfecting contact lenses and a method for disinfecting contact lenses using the same. More specifically, a contact in which a disinfectant preparation (A) containing an iodine-based disinfectant suitable for promptly and easily disinfecting a contact lens and a neutralizing / rinsing liquid agent (B) containing a reducing agent are combined. A composition for disinfecting a lens and a method for disinfecting a contact lens using the same.

[0002]

2. Description of the Related Art Contact lenses are roughly classified into hard contact lenses and soft contact lenses.
Of these, the soft contact lens may be contaminated by bacteria attached to the contact lens while the contact lens is removed from the eye or stored in the lens case. Then, wearing this contaminated contact lens on the eye may cause damage to the eye. Therefore, to prevent bacteria that adhere to contact lenses from infecting the eye,
Disinfection is said to be essential. At present, disinfection methods for soft contact lenses are roughly classified into boiling disinfection methods and chemical disinfection methods, and recently, in particular, chemical disinfection methods have become the mainstream.

The chemical disinfection method, which is the mainstream in the disinfection method for soft contact lenses, uses a method using 3% hydrogen peroxide solution and a method using a biguanide system and polydronium chloride as a disinfection component, which is generally called MPS. Is roughly divided into

However, in the method using 3% hydrogen peroxide solution, it is necessary to neutralize the hydrogen peroxide that has penetrated into the matrix of the contact lens after the disinfection, and in the case of insufficient neutralization, the corneal epithelium or The conjunctiva is strongly stimulated, which may cause corneal disorders in some cases. Further, in the method using MPS, the disinfecting effect on microorganisms such as Candida is insufficient, or the disinfecting component is adsorbed on the contact lens, which causes damage to the eyes when the contact lens after disinfection is worn. There is a fear. Further, there is a drawback that it requires scrubbing when used. Therefore, there is a need for a disinfecting composition for contact lenses, which has higher bio-safety, has a sufficient disinfecting effect, and yet has a simple contact lens care method.

In recent years, an iodine-based disinfectant, which has been attracting attention as a new disinfectant for contact lenses, is used as a mouthwash, a disinfectant for fingers, skin, etc. It is considered to be an excellent disinfectant in terms of both strength (disinfection effect) and safety. However, when an iodine-based disinfectant is used as a contact lens disinfectant, there is a problem that the iodine-based disinfectant is easily adsorbed on the contact lens, which causes the contact lens to be colored. Immediately after disinfecting contact lenses, it is necessary to neutralize residual iodine with a reducing agent.

As a method of using an iodine-based disinfectant as a disinfectant for contact lenses, a one-component combination preparation for disinfecting, neutralizing, and cleaning contact lenses, which contains an iodine-based disinfectant and a proteolytic enzyme, is used. One formulation and a combination of a second formulation comprising a sulfur-containing reducing agent and a foaming agent and having a delayed release coating, and a nonionic surfactant in at least one of the first formulation and the second formulation. A preparation containing an agent is disclosed (for example, see Patent Document 1). However, when this combination preparation is used, an aqueous solution for dissolution is separately required, and since three preparations are combined, there is a drawback that the convenience is lacking.

Further, some disinfection methods for contact lenses have been disclosed in which a disinfecting solution consisting of an aqueous solution of an iodine-based disinfectant and two solutions of an aqueous solution containing a reducing agent are combined. For example, a method for cleaning and disinfecting a contact lens using a liquid agent containing iodine, ethylenediaminetetraacetic acid and / or a soluble salt thereof and a nonionic surfactant in a predetermined ratio (see, for example, Patent Document 2), a polymer-bound iodine agent A method for cleaning and disinfecting contact lenses using a diluting solution containing an aqueous solution containing ethylenediaminetetraacetic acid and / or a soluble salt thereof and a nonionic surfactant together with a disinfecting solution containing an aqueous solution (for example, see Patent Document 3) is disclosed. ing.

However, in the methods described in Patent Document 2 and Patent Document 3, since the reducing power of ethylenediaminetetraacetic acid used as a reducing agent for the iodine-based disinfectant is weak, further reduction by the action of light is required. To do. Therefore, the disinfection treatment time may change depending on the weather, and in some cases, it may not be possible to completely neutralize the remaining iodine, which may cause a safety problem. Furthermore, disinfection in a fixed time
Since it may not be possible to define the neutralization treatment, it was of poor practicality.

Further, a bactericidal aqueous solution which dissipates available iodine contained in the iodine solution at a constant ratio,
A bactericidal aqueous solution having the composition of a) sorbic acid or a soluble salt thereof and b) ethylenediaminetetraacetic acid or a soluble salt thereof is disclosed (for example, refer to Patent Document 4). However, sorbic acid, which is used as an antiseptic agent having an antimicrobial effect, may adversely affect contact lenses and corneas, and thus has a drawback that it is not preferable to use it as a formulation for contact lenses.

[0010]

[Patent Document 1] Japanese Unexamined Patent Publication No. 9-111298

[Patent Document 2] Japanese Patent Laid-Open No. 10-108897

[Patent Document 3] JP-A-11-137649

[Patent Document 4] Japanese Patent Publication No. 58-22007

[0011]

An object of the present invention is to provide a disinfecting composition for contact lenses and a disinfecting method for contact lenses using the same, in which the above-mentioned drawbacks are improved. More specifically, a contact in which a disinfectant preparation (A) containing an iodine-based disinfectant suitable for promptly and easily disinfecting a contact lens and a neutralizing / rinsing liquid agent (B) containing a reducing agent are combined. Disclosed is a lens disinfecting composition and a contact lens disinfecting method using the same.

[0012]

According to the present invention, the above objects and advantages of the present invention are achieved by the following. (1) A disinfecting composition for contact lenses, which comprises a formulation in which the following (A) and (B) are combined. (A) Disinfectant formulation containing iodine-based disinfectant and non-liquid formulation, and (B) Neutralizing / rinsing liquid formulation (2) Disinfectant formulation (A) Iodine disinfectant
The above (1), which is at least one selected from the group consisting of povidone iodine and polyvinyl alcohol iodine.
The composition as described. (3) The composition according to (1) or (2) above, wherein the disinfectant preparation (A) further contains a proteolytic enzyme. (4) The composition according to any one of (1) to (3) above, wherein the disinfectant preparation (A) further contains at least one selected from the group consisting of a pH adjuster and an excipient. (5) The composition according to any one of (1) to (4) above, wherein the disinfectant preparation (A) has a dosage form selected from the group consisting of powders, tablets, granules and capsules. . (6) The composition according to any one of (1) to (5) above, wherein the reducing agent contained in the neutralizing / rinsing liquid agent (B) is a sulfur-containing reducing agent. (7) The neutralizing / rinsing liquid agent (B) further contains a surfactant,
The composition according to any one of (1) to (6) above, which contains at least one selected from the group consisting of chelating agents, buffering agents, isotonic agents and neutralizing auxiliary agents. (8) The composition according to (7) above, wherein the neutralizing auxiliary agent contained in the neutralizing / rinsing liquid agent (B) is at least one selected from the group consisting of polylysine and / or reducing sugar. (9) By immersing the contact lens in a mixed solution prepared by mixing and dissolving the disinfectant preparation (A) according to any one of (1) to (8) above with the neutralizing / rinsing liquid agent (B). ,
A disinfecting method for a contact lens, which comprises simultaneously disinfecting and neutralizing the contact lens. (10) A method of disinfecting a contact lens using the disinfectant preparation according to any one of (1) to (8), wherein the contact lens is immersed in a neutralizing / rinsing liquid agent (B). Then, the disinfectant preparation (A) is mixed with and dissolved in the liquid agent to disinfect and neutralize the contact lens at the same time.

[0013]

BEST MODE FOR CARRYING OUT THE INVENTION Disinfectant preparation (A): Among the disinfectant compositions for contact lenses of the present invention, the disinfectant preparation (A) contains an iodine-based disinfectant and has a non-liquid formulation. It is characterized by being a mold. As the iodine-based disinfectant which is an essential component of the disinfectant preparation (A), polyvinylpyrrolidone (PV) in which the iodine molecule (I ₂ ) is a macromolecule
P), polyvinyl alcohol (PVA) and cyclodextrin (CD) included povidone iodine, PV
Polymer complex iodine agents such as A iodine and CD iodine are preferable, but in the present invention, povidone iodine and PVA iodine are particularly preferable. These polymeric complex iodine agents (povidone iodine, PVA iodine, etc.)
Compared to ₂ ), it has the major advantages of 1) becoming water-soluble, 2) stabilizing sublimable and unstable iodine molecules in the solid state, and 3) reducing toxicity, and a powerful bactericidal action. It is an excellent disinfectant having That is,
Since the disinfectant has a broad antibacterial spectrum against bacteria, antibiotic-resistant bacteria, molds and viruses, these polymeric complex iodine agents are preferably used in the present invention.
However, in the present invention, any other stable iodine complex may be used, and two or more kinds of iodine-based disinfectants may be appropriately used in combination, but the iodine-based disinfectant is the only disinfectant. Are preferably used in.

In the disinfectant composition of the present invention, the iodine-based disinfectant is preferably contained in the disinfectant preparation (A) in the range of 0.008 to 8% by weight as the concentration of effective iodine, More preferable concentration is 0.04 to 4% by weight
And a particularly preferable concentration is in the range of 0.08 to 1.2% by weight.

The disinfectant preparation (A) of the present invention preferably further contains a proteolytic enzyme for the purpose of removing protein stains adhering to the contact lens. The proteolytic enzyme that is preferably contained in the disinfectant preparation (A) of the present invention is one that can sufficiently maintain the detergency against protein stains adhering to contact lenses in the presence of the above iodine-based disinfectant which is a strong oxidant. Must. Therefore, in the present invention, when the above-mentioned disinfectant preparation (A) contains a proteolytic enzyme, an iodine-based disinfectant which is relatively stable must be used. However, a sulfur atom such as a sulfur group, that is, a thiol group or a dithio group, is easily oxidized by an iodine compound, and therefore,
Enzymes having a large number of sulfur-containing groups are not suitable for use in the disinfectant preparation (A). Such proteolytic enzymes that are not suitable for use include, for example, papain, bromelain, ficin and cathepsin.

That is, as the proteolytic enzyme that is preferably contained in the disinfectant preparation (A), a commonly used proteolytic enzyme may be used as long as it is relatively stable to an iodine-based disinfectant. However, the present inventors, in the presence of the iodine-based disinfectant, as a result of a stability test using various enzymes, especially proteolytic enzymes derived from animals such as cattle and pigs and microorganism-derived It has been found that a proteolytic enzyme is preferable, and furthermore, as a microorganism-derived proteolytic enzyme, a proteolytic enzyme derived from Bacillus is particularly preferable. Commercially available proteolytic enzymes derived from these animals and Bacillus include, for example, "Bioprase", "Biotamylase" (Nagase ChemteX Corporation), "Protease N" Amano "".
(Amano Enzyme Inc.), “Subtilisin A”,
There are “Alcalase”, “Esperase”, “Trypsin”, “Chymotrypsin” (Novo Nordisk Bioindustry Japan) and the like, and in the present invention, at least one kind is selected appropriately from the above-mentioned proteolytic enzymes. Can be used. In the present invention, when the disinfectant preparation (A) contains a proteolytic enzyme, the concentration in the disinfectant preparation (A) is preferably in the range of 0.005 to 50% by weight, more preferably the concentration. Is in the range of 0.05 to 25% by weight, and a particularly preferred concentration is in the range of 0.5 to 10% by weight.

The disinfectant preparation (A) has a non-liquid dosage form, and the dosage form is preferably selected from the group consisting of powder, tablets, granules and capsules. Therefore, the disinfectant preparation (A) may contain a pH adjusting agent such as sodium carbonate and citric acid and an excipient such as D-mannitol or lactose, if necessary.

Further, in the present invention, the disinfectant preparation (A) may contain a surfactant, if necessary, in addition to the above-mentioned essential components and components such as proteolytic enzyme. The surfactant that can be contained in the disinfectant preparation (A) is not particularly limited as long as it is a surfactant that is generally used as a contact lens agent, but a nonionic surfactant is particularly preferable. The nonionic surfactant that can be contained as necessary, polyoxyethylene-polyoxypropylene block copolymer, polyoxyethylene alkyl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene sorbitan alkyl ester, Examples thereof include polyoxyethylene hydrogenated castor oil, fatty acid monoglyceride, propylene glycol fatty acid ester, fatty acid sucrose ester and polyoxyethylene-polyoxypropylene ethylenediamine condensate. In addition to these, a cationic surfactant, an anionic surfactant and an amphoteric surfactant may be used, and two or more kinds of surfactants may be appropriately used in combination. When using a cationic surfactant, an anionic surfactant, or an amphoteric surfactant, the disinfecting effect when contained in the composition for disinfecting contact lenses of the present invention is confirmed in advance and a combination is selected. Should.

In order to produce the above disinfectant preparation (A) in the present invention, for example, when the dosage form is granules, first, a pH adjusting agent and an excipient are pulverized and then iodine-based. Industrially advantageous production can be achieved by mixing a disinfectant, and then adjusting the humidity, granulating and drying with ethanol and water. In the case of other dosage forms, it can be manufactured by a generally known method.

Generally, an aqueous solution of iodine molecules is colored from dark brown to yellow depending on its concentration, and iodine is easily attached to an organic compound as used as a color former for thin layer chromatography of silica gel or alumina. The material of the matrix of the soft contact lens to be disinfected is composed of a methacrylic acid derivative, an acrylamide derivative and an organic polymer such as N-vinylpyrrolidone, so that iodine molecules are easily attached to the lens matrix during disinfection, The lens may be colored yellow or brown. At this time, if this state continues for a long time, there is a possibility that the material of the lens may be modified or deteriorated.
Therefore, it is necessary to immediately neutralize the excess iodine molecules remaining after the disinfection is effectively performed with iodine. Therefore, the disinfecting composition of the present invention comprises a combination of the above-mentioned disinfectant preparation (A) and the neutralizing / rinsing liquid agent (B) described below. Used in combination.

Regarding Neutralizing / Rinsing Solution (B): Among the contact lens disinfecting compositions of the present invention, the neutralizing / rinsing solution (B) is an iodine-based agent contained in the above disinfectant preparation (A). A liquid agent having a function of neutralizing a disinfectant, wherein the neutralizing / rinsing liquid agent (B) contains at least a reducing agent, and further contains a surfactant, a chelating agent, a buffering agent, if necessary.
A tonicity agent, a neutralization auxiliary agent, etc. may be contained.

As the reducing agent contained in the neutralizing / rinsing liquid agent (B), those known as strong reducing agents for iodine and halogenating agents can be used.
Among these reducing agents, a sulfur-containing reducing agent is particularly preferable for neutralizing the iodine-based disinfectant, which is the disinfecting component of the disinfectant preparation (A). Examples of the sulfur-containing reducing agent preferably used for neutralization include sodium thiosulfate, sodium sulfite and sodium hydrogen sulfite. A reducing agent containing no sulfur can also be used, and examples thereof include ascorbic acid and sodium ascorbate. All of these reducing agents are particularly preferable because they effectively neutralize iodine molecules remaining in the contact lens after disinfection. The reducing agent is 0.00002 to 0.03 w / based on the volume of the neutralizing / rinsing liquid agent (B).
It is preferably contained at a concentration of v%, more preferably 0.0002 to 0.015 w / v%, and further 0.00
It is preferably contained at a concentration of 05 to 0.0045 w / v%, and more preferably 0.001 to 0.0045 w / v%.

Further, the above neutralizing / rinsing liquid agent (B)
In order to remove the lipid adhering to the contact lens, a surfactant may be added, if necessary, and in many cases, it is preferable. As such a surfactant,
The same thing as what was described in the disinfectant formulation (A) can be exemplified. The concentration of the surfactant is preferably 0.005 to 5 w / v% based on the volume of the liquid agent (B), more preferably 0.05 to 5 w / v.
%, More preferably 0.05 to 0.5 w / v%.

Further, the neutralizing / rinsing liquid agent (B) is
Further, for the purpose of removing stains such as calcium adhering to the contact lens, a chelating agent may be optionally contained, and in many cases, it is preferable. As the chelating agent that can be contained in the liquid agent (B),
Examples thereof include ethylenediaminetetraacetic acid, gluconic acid, citric acid, tartaric acid, diethylenediaminepentaacetic acid and their sodium or potassium salts, sodium polyphosphate, sodium nitrilotriacetate and the like. The concentration of the chelating agent is 0.01 to 0.5 based on the volume of the liquid agent (B).
w / v% is preferable, and further 0.05 to 0.2 w / v
% Is more preferable.

Further, the neutralizing / rinsing liquid agent (B) includes
If desired, a buffering agent may be contained, and in many cases, it is preferable. The buffering agent is intended to stabilize the pH of the liquid agent (B), and examples of the buffering agent that can be contained in the liquid agent (B) include boric acid, borax, citric acid,
Examples include disodium hydrogen phosphate, sodium dihydrogen phosphate, and tris (hydroxymethyl) aminomethane. The concentration of the buffer is preferably 0.01 to 5 w / v%, more preferably 0.1 to 1 based on the volume of the liquid agent (B).
w / v% is more preferable.

Further, the neutralizing / rinsing liquid agent (B) includes
For the purpose of alleviating eye irritation, a tonicity agent may be contained, if necessary, and in many cases, it is preferable.
Examples of the tonicity agent that can be contained in the liquid agent (B) include sodium chloride, potassium chloride and the like. The concentration of the isotonicity agent is preferably 0.01 to 0.9 w / v% based on the volume of the liquid agent (B), and further 0.1
-0.7 w / v% is more preferable.

In the present invention, the neutralizing / rinsing liquid agent (B) may further contain a neutralizing auxiliary agent. Examples of such neutralization aids include polylysine and / or reducing sugars typified by maltose. These neutralization auxiliary agents have the effect of assisting the neutralization of the iodine-based disinfectant by the reducing agent. In the present invention, in order to ensure the disinfecting effect of the contact lens by the iodine-based disinfectant, the concentration of the reducing agent is preferably set to a concentration at which the iodine-based disinfectant is not neutralized in a short time, therefore In the present invention, the neutralizing / rinsing liquid agent (B) preferably contains the neutralizing auxiliary agent as described above.

In addition, polylysine given as an example of the neutralization auxiliary agent is a component newly proposed as a disinfectant for contact lenses in recent years. Therefore, when the neutralizing / rinsing liquid agent (B) contains polylysine, the liquid agent (B) has an effect of assisting disinfection of the contact lens by the iodine-based disinfectant in the disinfectant preparation (A). . Furthermore, normally, the solution after the iodine-based disinfectant has been completely neutralized does not have an antiseptic effect, but since polylysine also has an antiseptic effect, the solution containing polylysine has an antiseptic effect even after the completion of neutralization. Can last. Therefore, in the present invention, it is particularly preferable to contain polylysine as a neutralization aid. The concentration of the neutralizing auxiliary agent such as polylysine contained in the neutralizing / rinsing liquid agent (B) is preferably 0.001 to 5 w / v% based on the volume of the liquid agent (B), and more preferably 0.
01 to 2 w / v% is more preferable.

In order to produce such a neutralizing / rinsing liquid agent (B), a surfactant is put in an appropriate amount of a solvent such as water and dissolved by heating, and various components other than the surfactant are dissolved after cooling, After that, the pH is adjusted with an acid or an alkali, and finally the volume is adjusted, whereby it can be industrially advantageously produced.

The composition for disinfecting contact lenses of the present invention is a preparation in which the above-mentioned respective components are combined, and among them, a combination preparation containing the following respective components in the following concentrations is particularly preferable. (A) Povidone iodine 0.8-12 wt% Proteolytic enzyme 0.5-10 wt% (B) Sulfur-containing reducing agent 0.001-0.0045 w / v% Nonionic surfactant 0.05-0. 5w / v% Chelating agent 0.05-0.2w / v% Buffering agent 0.1-1w / v% Isotonic agent 0.1-0.7w / v% Neutralization auxiliary agent 0.01-2w / V%

As a method for disinfecting a contact lens using the disinfecting composition of the present invention, specifically, 1) mixing and dissolving the disinfectant preparation (A) in the neutralizing / rinsing liquid agent (B). A method of simultaneously disinfecting and neutralizing the contact lens by immersing the contact lens in the mixed solution described above, or 2) immersing the contact lens in the neutralizing / rinsing liquid agent (B) and then disinfecting in the liquid agent. Examples include a method of simultaneously sterilizing and neutralizing the contact lens by mixing and dissolving the pharmaceutical preparation (A). After disinfection, when the iodine molecule is neutralized by the reducing agent, it is changed to iodoanion which is colorless and safe and has almost no ability to be adsorbed to the lens matrix. At that time, when the color of the solution colored yellow or brown gradually fades and becomes colorless, the neutralization is completed, but the process can be visually observed. The contact lens is put on the eye after the neutralization is completed, preferably after further rinsing the contact lens with the neutralizing / rinsing liquid agent (B). When a proteolytic enzyme is contained, the contact lens must be rinsed with the neutralizing and rinsing liquid (B) before being put on the eye.

[0032]

EXAMPLES The present invention will be specifically described below with reference to Examples and Comparative Examples, but the present invention is not limited thereto.

Example 1 Disinfectant preparation (A) having the composition shown in Table 1 below and neutralization
A rinsing liquid agent (B) was prepared.

[0034]

[Table 1]

Using the compositions 1 to 4 and the composition of Comparative Example 1 shown in Table 1, the respective disinfection effects were examined as follows. First, Serratia (bacteria) as a test bacterium
And Candida (fungi) were selected and these fungi were
The inoculum was prepared according to the method described for the standalone test. This Serratia and Candida strain 0.1
mL was mixed with 10 mL of each of the neutralizing and rinsing liquids (B) of Compositions 1 to 4 and Comparative Example 1 shown in Table 1, and each disinfectant preparation (A) was further added to the neutralizing and rinsing liquids (B ) Was mixed and dissolved, and the mixture was gently shaken so as to be uniform, and then allowed to stand for about 6 hours. After standing for about 6 hours, the number of viable bacteria of Serratia and Candida remaining in this mixed solution was measured. The measurement results of each solution are shown in Table 2.

[0036]

[Table 2]

From the results shown in Table 2, compositions 1 to 4 containing povidone iodine as an iodine-based disinfectant showed significantly higher residual numbers of both Serratia and Candida than Comparative Example 1 containing no povidone iodine. It was confirmed that the disinfection effect was excellent. Regarding the disinfecting auxiliary effect of polylysine, when composition 1 and composition 2 and composition 3 and composition 4 having the same iodine disinfectant concentration were compared, composition 1 and composition 4 containing polylysine were compared. Was slightly superior in disinfection effect to the compositions 2 and 3 containing no polylysine.
Therefore, it was confirmed that when polylysine was contained as a neutralization auxiliary in the present invention, it also had a disinfection auxiliary effect.

Example 2 The compositions 1 to 4 shown in Table 1 and the composition of Comparative Example 2 were used to examine the neutralizing effect of each. Compositions 1-4
Then, 8 mL of each neutralizing and rinsing liquid agent (B) of Comparative Example 2 and each disinfectant preparation (A) were mixed and dissolved, and the mixture was gently shaken so as to be uniform, and then FD was apt to adhere to the aqueous solution.
A commercially available soft contact lens "Menicon Soft S" (manufactured by Menicon Co., Ltd.) belonging to A classification group 2 was immersed and left at 10 ° C for 6 hours. After 6 hours, the contact lens was taken out, rinsed with the neutralizing / rinsing liquid agent (B), and then the color change of each contact lens was visually observed. As a result, it was confirmed that all the contact lenses treated with the compositions 1 to 4 were not discolored and could be completely neutralized. In addition, composition 1, composition 2, and composition 4 containing the neutralization auxiliary agent have a reducing agent concentration of about half that of composition 3 containing no neutralization auxiliary agent. ,
It has been found that it has a sufficient neutralizing effect, and the neutralizing auxiliary agent used in the present invention has a sufficient neutralizing auxiliary effect. Further, in Comparative Example 2 containing no reducing agent, the lens was colored yellow or brown after 6 hours, and thus it was confirmed that the neutralization was incomplete.

Example 3 The compositions of Compositions 1 to 3 shown in Table 1 were used to examine the cleaning effect on protein stains adhering to contact lenses when the composition contained a proteolytic enzyme. That is, a commercially available soft contact lens "Viewno I" (Offtex Co., Ltd.) belonging to FDA classification group 1 is immersed in 5 mL of an artificial dirt model solution consisting of 0.1% egg white lysozyme, and heated at 80 ° C for 1 hour. Then, heat-denatured lysozyme was attached to the lens. The lens was left to cool at room temperature and then rubbed with an ISO physiological saline solution to remove excess dirt on the lens surface to obtain an artificial dirt lens. Three artificial dirt lenses obtained in this way were used for U-1500 type ratio beam spectrophotometer (Co., Ltd.).
(Manufactured by Hitachi, Ltd.) was used to measure the absorbance at OD 450 nm, and the measurement result was designated as X. Each measured lens is individually set in a lens case, and the lens is immersed in 8 mL of the neutralizing / rinsing liquid agent (B) of Compositions 1 to 3, and then the disinfectant preparation (A) is added to the liquid agent. Mix and dissolve
After gently shaking so as to be uniform, the mixture was left at room temperature for 6 hours. After 6 hours, remove the contact lens and neutralize
After rinsing with the rinsing liquid agent (B), the absorbance was measured at OD450 nm, and the measurement result was designated as Y. The stain removal rate (%) from the lens was calculated by 100− (Y / X × 100), and the results are shown in Table 3.

[0040]

[Table 3]

From the results in Table 5, it was confirmed that the compositions 1 to 3 in which the composition of the present invention contained a proteolytic enzyme exhibited a cleaning effect.

[0042]

The present invention contains an iodine-based disinfectant,
Further, by using a combination of the disinfectant preparation (A) whose formulation is a non-liquid formulation and the neutralizing / rinsing solution (B) containing a reducing agent, the contact lens can be more simply and safely used,
In particular, it is possible to disinfect microorganisms and the like attached to the soft contact lens. Therefore, a series of contact lens cares covering disinfection and neutralization can be easily performed.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A01N 43/36 A01N 43/36 C G02C 13/00 G02C 13/00 F term (reference) 2H006 DA08 DA09 4C058 AA09 BB07 JJ02 JJ08 4H011 AA02 BA02 BB02 BB09 BC06 BC09 BC18 BC19 DA02 DA03 DA05 DD01 DH03 DH10

Claims (10)

[Claims] 1. A disinfecting composition for contact lenses, which comprises a formulation in which the following (A) and (B) are combined. (A) Disinfectant formulation containing iodine-based disinfectant and non-liquid formulation, and (B) Neutralizing / rinsing liquid formulation containing reducing agent 2. The composition according to claim 1, wherein the iodine-based disinfectant contained in the disinfectant preparation (A) is at least one selected from the group consisting of povidone iodine and polyvinyl alcohol iodine. 3. The composition according to claim 1, wherein the disinfectant preparation (A) further contains a proteolytic enzyme. 4. The composition according to any one of claims 1 to 3, wherein the disinfectant preparation (A) further contains at least one selected from the group consisting of a pH adjuster and an excipient. 5. The composition according to claim 1, wherein the disinfectant preparation (A) has a dosage form selected from the group consisting of powders, tablets, granules and capsules. . 6. The composition according to claim 1, wherein the reducing agent contained in the neutralizing / rinsing liquid agent (B) is a sulfur-containing reducing agent. 7. The neutralizing / rinsing liquid agent (B) further contains at least one selected from the group consisting of a surfactant, a chelating agent, a buffering agent, an isotonicity agent and a neutralizing auxiliary agent. Item 7. The composition according to any one of items 1 to 6. 8. The composition according to claim 7, wherein the neutralization auxiliary agent contained in the neutralizing / rinsing liquid agent (B) is at least one selected from the group consisting of polylysine and / or reducing sugar. 9. By immersing a contact lens in a mixed solution prepared by mixing and dissolving the disinfectant preparation (A) according to any one of claims 1 to 8 in a neutralizing / rinsing liquid agent (B). A method for disinfecting a contact lens, which comprises simultaneously disinfecting and neutralizing the contact lens. 10. A method for disinfecting a contact lens using the disinfectant preparation according to any one of claims 1 to 8, wherein the contact lens is immersed in a neutralizing / rinsing liquid agent (B). Then, the disinfectant preparation (A) is mixed with and dissolved in the liquid agent to disinfect and neutralize the contact lens at the same time.