JP2006089403A - Ophthalmic composition for taking out contact lens - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain an ophthalmic composition for enabling a contact lens to be easily taken out without adding excessive force and without using tools such as a sucker and a dropping pipet even if the contact lens adheres to the eye. <P>SOLUTION: This ophthalmic composition for taking out the contact lens is an aqueous composition having 0.01-0.12 or 0.29-0.56 ion strength, and preferably further contains at least one kind of medicinal component selected from a cornea-protecting agent, vitamins and amino acids. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to an ophthalmic composition for removing contact lenses.

  To remove a contact lens from the eye, usually remove it by pinching it with a finger in the case of a soft contact lens, and in the case of a hard contact lens, pull the corner of the eye with a finger and pinch the contact lens with the upper and lower eyelids to blink The method of removing by is common. In addition, the contact lens can be adsorbed by using a tool such as a contact suction desorption device (see Patent Document 1) having a contact lens suction section at the tip of a dropper or a contact lens removing tool (see Patent Document 2) having a suction cup. A method of removing it is also proposed. However, there are cases where the contact lens adheres to the cornea due to prolonged wearing or insufficient secretion of tears, making it difficult to remove the contact lens. Under such circumstances, if the above normal removal method is used, the contact lens is likely to be removed by applying excessive force with a finger or an instrument, and the contact lens may be damaged. There is a risk of injury to the eyelids.

  Although contact lens mounting liquid (see Patent Document 3) and eye drops (see Patent Document 4) that improve the safety and wearing feeling of contact lens wearing eyes are known, ophthalmology for facilitating the removal of contact lenses The composition is not known.

JP 2003-255276 A JP-A-10-197832 JP 2003-66383 A Japanese Patent Laid-Open No. 61-246119

  In the above background, the present invention allows the contact lens to be easily removed without applying excessive force or using an instrument such as a suction cup or a spoid even when the contact lens is adhered to the eye. An object of the present invention is to provide an ophthalmic composition for the purpose.

  As a result of studies aimed at achieving the above object, the present inventor applies an aqueous composition (aqueous solution) having an ionic strength of 0.01 to 0.12 or 0.29 to 0.56 to the eye wearing a contact lens. As a result, it has been found that the contact lens can be easily removed, and further research has been made to complete the present invention.

That is, the present invention provides the following.
(1) An ophthalmic composition for removing a contact lens, which is an aqueous composition having an ionic strength of 0.01 to 0.12 or 0.29 to 0.56,
(2) The ophthalmic composition according to the above (1), further comprising at least one pharmaceutical ingredient selected from the group consisting of a corneal protective agent, vitamins and amino acids, and (3) the above-mentioned eye drop The ophthalmic composition according to (1) or (2).

  According to the present invention, the contact lens that adheres to the cornea on the surface and becomes difficult to remove by the conventional method can be easily removed, so there is substantially no risk of damaging the cornea, conjunctiva or eyelid, or damaging the contact lens. Can be eliminated.

  In the present invention, the “ophthalmic composition for removing a contact lens” refers to a composition applied to the eye for the purpose of facilitating the removal when the contact lens attached to the eye is removed.

  The ophthalmic composition of the present invention may be in any form as long as it can be easily applied to a contact lens wearing eye, and is preferably an eye drop. Examples of eye drops include eye drops, eye washes, and the like, and eye drops are particularly preferable.

  The ophthalmic composition of the present invention can be applied to any of soft contact lenses, hard contact lenses, and oxygen-permeable hard contact lenses without any particular limitation on the lens type. Soft contact lenses are group I of non-ionic materials with a moisture content of less than 50% (low moisture content) according to the FDA (Federal Food and Drug Administration) classification, nonionic materials with a moisture content of 50% or more (high moisture content) Ratio) group II, ionic material low water content group III, and ionic material high water content group IV soft contact lenses, among these, the ophthalmic composition of the present invention, It is preferably used for group IV soft contact lenses.

The ionic strength in this specification is defined by the following formula.
Ionic strength = 1 / 2ΣCiZi2 ²
(Where Ci is the molar concentration of the ionic species i dissociated in the solution, and Zi is the number of charges of the ionic species i.)

  The ionic strength range of the ophthalmic composition of the present invention is 0.01-0.12 or 0.29-0.56.

  In the ophthalmic composition of the present invention, examples of the compound preferably used for adjusting the ionic strength to the above range include water-soluble inorganic salts, specifically, for example, sodium chloride, potassium chloride, calcium chloride. , Magnesium chloride and the like, but are not limited thereto.

  The ophthalmic composition of the present invention is adjusted to have a pH of 4 to 9, preferably 5 to 8, with a buffer and a pH adjuster. Examples of the buffer used include, but are not limited to, those composed of sodium citrate, sodium acetate, boric acid, ε-aminocaproic acid and the like and salts thereof. Examples of the pH adjuster include hydrochloric acid, acetic acid, citric acid, sodium hydroxide, potassium hydroxide and the like, but are not limited thereto.

  In the ophthalmic composition of the present invention, the water-soluble inorganic salts, the buffering agent and the pH adjuster may be used in such an amount that the ionic strength is within the above range, and as long as the combination and ratio thereof are not particularly limited. Not.

  In addition, the ophthalmic composition of the present invention contains a preservative (eg, paraoxybenzoates, chlorobutanol, benzyl alcohol, sodium dehydroacetate, sodium edetate, benzalkonium chloride, Benzethonium, sorbic acid or its salt, etc.), stabilizers (eg sodium bisulfite, sodium thiosulfate, sodium edetate, ascorbic acid, dibutylhydroxytoluene, etc.), water-soluble polymers (hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropyl) Methylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, etc.), cooling agents (eg, menthol, camphor, borneol, etc.), surfactants (eg, polysorbate 80, polyoxyethylene hydrogenated castor oil 60, Additives, etc.) and the like Rokisaporu may appropriately be contained.

  Further, in the ophthalmic composition of the present invention, pharmaceutical ingredients that can be blended in the conventional ophthalmic composition, for example, anti-inflammatory drugs such as dipotassium glycyrrhizinate and allantoin, diphenhydramine hydrochloride, maleic acid, etc. Antihistamines such as chlorpheniramine, corneal protective agents such as sodium chondroitin sulfate and sodium hyaluronate, vitamins such as α-tocopherol and pyridoxine, amino acids such as aminoethylsulfonic acid, aspartic acid or its salts, epinephrine hydrochloride, hydrochloric acid A decongestant such as naphazoline and tetrahydrozoline hydrochloride and a parasympathomimetic agent such as neostigmine methyl sulfate may be included. Among these, particularly preferred pharmaceutical ingredients to be included are corneal protective agents, vitamins and amino acids.

  These pharmaceutical ingredients may be contained at concentrations conventionally used in conventional ophthalmic compositions, and such concentrations are well known to those skilled in the art. Specifically, it varies depending on the kind of the pharmaceutical ingredient, but it may be contained at a concentration that can achieve the pharmacological effect of each pharmaceutical ingredient. In general, for example, the corneal protective agent is about 0.01 to about 1 w / v. %, Vitamins about 0.001 to about 0.5 w / v%, amino acids about 0.01 to about 1 w / v%.

  The ophthalmic composition of the present invention may be produced according to a conventional production method for ordinary eye drops, and can be produced, for example, by the method described in the eye drops of the 14th revised Japanese Pharmacopoeia, General Rules for Preparations.

  When the ophthalmic composition of the present invention is used as an ophthalmic solution for a contact lens adhered to the corneal surface, for example, if 2 to 3 drops are instilled into the contact lens wearing eye, then a normal method without using an instrument or the like In addition, the contact lens can be easily removed without applying excessive force.

  The present invention will be described in more detail below with reference to examples and test examples, but these are merely examples and are not intended to limit the present invention.

[Test Example 1] Influence on diameter of soft contact lens (test method)
One-Day Accuview (manufactured by Johnson & Johnson, base curve: 9.0 mm, power: −3.00, lens diameter 14.2 mm), which is a group IV soft contact lens according to FDA classification, was used. The contact lens was immersed in phosphate buffered saline (PBS) at pH 7.4 for 5 minutes at room temperature, and then the diameter was measured. Next, the contact lens was immersed in a petri dish containing any one of the test solutions shown in Tables 1 and 2 at room temperature for 5 minutes, and then the diameter was measured again. This operation was sequentially repeated, and the change amount and change rate of the contact lens diameter were calculated according to the following formula.

Contact lens diameter change (mm) = [Contact lens diameter after immersion in each test solution] − [Contact lens diameter after PBS immersion]
Contact lens diameter change rate (%) = [contact lens diameter after immersion in each test solution] / [contact lens diameter after PBS immersion] × 100

(Test results)
The test results are shown in Tables 3 and 4.

  As shown in Tables 3 and 4, the contact lenses soaked in the test solutions of Examples 1 to 5 increased in diameter and swollen. This suggests that the value of the base curve of the contact lens has increased (that is, the curve has become loose). In addition, the contact lenses immersed in the test solutions of Examples 6 to 12 were reduced in diameter and contracted. This indicates that the value of the base curve of the contact lens has become smaller (that is, the curve has become sharper). From these results, the base curve of the contact lens reversibly changes remarkably by contact with the ophthalmic composition for removing a contact lens of the present invention, which is a low ionic strength or high ionic strength solution, and matches the curve of the corneal surface. It is considered that the contact lens is lifted partially from the corneal surface, and the contact area between the corneal surface and the contact lens is reduced, so that the contact lens can be easily removed.

[Test Example 2] Weight change of cornea (test method)
Rabbits (Dutch species) were used. After euthanasia, the eyeball was removed and the cornea was immediately removed. The water on the surface of the cornea taken out was wiped off, and the weight was measured to obtain an initial value. The cornea was immersed in a beaker containing 10 mL of each of the following test solutions, and after 5 minutes, the cornea was taken out and the surface moisture was wiped off. Then, the cornea weight was measured (n = 3). The initial value was set to 100, and the weight ratio of the cornea after being immersed in each test solution was determined.
(Test solution)
Control solution: Purified water Test solution A: 0.9% sodium chloride aqueous solution (ionic strength: 0.154)
Test solution B: 3.0% sodium chloride aqueous solution (ionic strength: 0.513)

(Test results)
The test results are shown in FIG.

  As shown in FIG. 1, the corneal weight was significantly reduced in the test solution B having a high ionic strength. This indicates that water has decreased from within the cornea. From this result, it is considered that water is exuded from the cornea between the contact lens and the cornea due to the solution having a high ionic strength, which also facilitates the removal of the contact lens.

[Formulation Example 1] Ophthalmic Solution for Removing Contact Lenses An ophthalmic solution was prepared by a conventional method according to the following prescription.
Sodium chloride ... 0.1g
Hydrochloric acid or sodium hydroxide ... appropriate amount of purified water ... 100mL in total
pH ... 7.4

[Formulation Example 2] Ophthalmic solution for removing contact lens An ophthalmic solution was prepared by a conventional method according to the following prescription.
Sodium chloride ... 3g
Hydrochloric acid or sodium hydroxide ... appropriate amount of purified water ... 100mL in total
pH ............ 7.2

[Formulation Example 3] Ophthalmic Solution for Removing Contact Lenses An ophthalmic solution was prepared by a conventional method according to the following prescription.
Sodium chloride ... 0.1g
Sodium citrate ... 0.2g
Hydrochloric acid or sodium hydroxide ... appropriate amount of purified water ... 100mL in total
pH: 7.0

[Formulation Example 4] Ophthalmic solution for removing contact lens An ophthalmic solution was prepared by a conventional method according to the following prescription.
Sodium chloride ... 3g
Sodium citrate ... 0.2g
Hydrochloric acid or sodium hydroxide ... appropriate amount of purified water ... 100mL in total
pH: 7.0

[Formulation Example 5] An ophthalmic solution for removing a contact lens An ophthalmic solution was prepared by a conventional method according to the following prescription.
Sodium chloride ... 0.1g
Sodium citrate ... 0.2g
Hydrochloric acid or sodium hydroxide ... appropriate amount of purified water ... 100mL in total
pH ... 5.0

[Formulation Example 6] Ophthalmic Solution for Removing Contact Lenses An ophthalmic solution was prepared by a conventional method according to the following prescription.
Sodium chloride ... 3g
Sodium citrate ... 0.2g
Hydrochloric acid or sodium hydroxide ... appropriate amount of purified water ... 100mL in total
pH ... 5.0

[Preparation Example 7] Ophthalmic solution for removing contact lens An ophthalmic solution is prepared by a conventional method according to the following prescription.
Sodium chloride ... 0.1g
Sodium citrate ... 0.2g
Chondroitin sulfate sodium salt 0.1g
Acetic acid d-α-tocopherol: 0.025 g
Pyridoxine hydrochloride: 0.05g
L-aspartate potassium 0.5g
Edetate sodium ... 0.01g
Hydrochloric acid or sodium hydroxide ... appropriate amount of purified water ... 100mL in total
pH: 7.0

[Formulation Example 8] Ophthalmic solution for removing contact lens An ophthalmic solution is prepared by a conventional method according to the following prescription.
Sodium chloride ... 0.1g
Sodium citrate ... 0.2g
Sodium hyaluronate 0.1g
Acetic acid d-α-tocopherol: 0.025 g
Pyridoxine hydrochloride: 0.05g
Aminoethylsulfonic acid 0.5g
Chlorobutanol ... 0.2g
Sorbic acid ... 0.1g
Hydrochloric acid or sodium hydroxide ... appropriate amount of purified water ... 100mL in total
pH ... 5.5

  ADVANTAGE OF THE INVENTION According to this invention, the ophthalmic composition which makes easy removal of the contact lens which adhered to the cornea surface and became difficult to remove can be provided.

6 is a graph showing changes in rabbit cornea weight in Test Example 2. Each value represents mean + standard deviation (n = 3). * Represents a significant difference p <0.0005 with respect to test solution A by Student's T test.

Claims (3)

  An ophthalmic composition for removing a contact lens, which is an aqueous composition having an ionic strength of 0.01 to 0.12 or 0.29 to 0.56.   The composition according to claim 1, further comprising at least one pharmaceutical ingredient selected from the group consisting of a corneal protective agent, vitamins, and amino acids. The composition according to claim 1 or 2, which is an eye drop.

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