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JP2006181088A - Medical wire - Google Patents

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JP2006181088A
JP2006181088A JP2004377574A JP2004377574A JP2006181088A JP 2006181088 A JP2006181088 A JP 2006181088A JP 2004377574 A JP2004377574 A JP 2004377574A JP 2004377574 A JP2004377574 A JP 2004377574A JP 2006181088 A JP2006181088 A JP 2006181088A
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indwelling device
connecting member
medical wire
shape memory
conductive linear
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Hiroo Iwata
博夫 岩田
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Kyoto University NUC
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Kyoto University NUC
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Priority to JP2004377574A priority Critical patent/JP2006181088A/en
Priority to PCT/JP2005/023351 priority patent/WO2006070641A1/en
Publication of JP2006181088A publication Critical patent/JP2006181088A/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B21—MECHANICAL METAL-WORKING WITHOUT ESSENTIALLY REMOVING MATERIAL; PUNCHING METAL
    • B21F—WORKING OR PROCESSING OF METAL WIRE
    • B21F35/00—Making springs from wire
    • B21F35/006—Double twist coil springs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12009—Implements for ligaturing other than by clamps or clips, e.g. using a loop with a slip knot
    • A61B17/12013—Implements for ligaturing other than by clamps or clips, e.g. using a loop with a slip knot for use in minimally invasive surgery, e.g. endoscopic surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/1214—Coils or wires
    • A61B17/12145—Coils or wires having a pre-set deployed three-dimensional shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205—Introduction devices
    • A61B2017/12054—Details concerning the detachment of the occluding device from the introduction device
    • A61B2017/12068—Details concerning the detachment of the occluding device from the introduction device detachable by heat
    • A61B2017/12077—Joint changing shape upon application of heat, e.g. bi-metal or reversible thermal memory
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09—Guide wires

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Surgical Instruments (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

【課題】体内留置具の直接加熱による生体組織への侵襲がなく、容易に体内留置具とガイドワイヤーとを分離することができる医療用ガイドワイヤーの提供。
【解決手段】導電性の線状部材１の先端部に電気絶縁部材４および接続部材３を介して体内留置具２が接続されてなり、接続部材が形状記憶合金からなり、線状部材に高周波電流が供給されると接続部材が熱されて変形し、該変形によって体内留置具が切り離されるように構成された医療用ワイヤー。
【選択図】図１Provided is a medical guide wire that can easily separate an indwelling device from a guide wire without invading a living tissue by direct heating of the indwelling device.
An indwelling device 2 is connected to a distal end portion of a conductive linear member 1 via an electrical insulating member 4 and a connecting member 3, the connecting member is made of a shape memory alloy, and a high frequency is applied to the linear member. A medical wire configured such that when a current is supplied, a connecting member is heated and deformed, and the indwelling device is separated by the deformation.
[Selection] Figure 1

Description

本発明は、生体内の所定の個所に体内留置具を留置させるための医療用ワイヤーに関する。   The present invention relates to a medical wire for indwelling an indwelling device at a predetermined location in a living body.

医療用ワイヤーは、通常、血管内治療（例えば動脈瘤、動静脈奇形、動静脈瘻または腫瘍の治療）に用いられている。このような血管内治療は、医療用ワイヤーを用いて、生体内の所定の箇所に体内留置具を設置することにより実施される。
例えば医療用ワイヤーが動脈瘤の治療に適用される場合には、体内留置具として白金からなる二次コイルが用いられ、医療用ワイヤー先端の二次コイルを動脈瘤の瘤内に設置することにより動脈瘤の治療が行われる。設置作業は、通常、二次コイルと医療用ワイヤーの線状部材（ガイドワイヤー）とを分離することにより行われ、分離手段としては、電気分解法を利用する方法、接続部材としてポリビニルアルコール（ＰＶＡ樹脂）などを用い、該ＰＶＡ樹脂を溶断して分離する方法、二次コイルとガイドワイヤーとをネジ構造にて接合し、ネジを取り外して分離する方法が従来から用いられてきた。
しかしながら、これら従来の分離手段を用いた場合、二次コイルの設置が何度も繰り返し行われるため、二次コイルとガイドワイヤーとの分離作業に膨大な時間や手間を必要とし、また、ポリビニルアルコール樹脂を前もって生理食塩水になじませる手間を必要とし、手術時間の長期化、医者や患者への負担の増大といった問題が生じる。 Medical wires are commonly used for endovascular treatment (eg, treatment of aneurysms, arteriovenous malformations, arteriovenous fistulas or tumors). Such intravascular treatment is performed by installing an indwelling device at a predetermined location in a living body using a medical wire.
For example, when a medical wire is applied to the treatment of an aneurysm, a secondary coil made of platinum is used as an indwelling device, and the secondary coil at the distal end of the medical wire is placed in the aneurysm An aneurysm is treated. The installation work is usually performed by separating the secondary coil and the linear member (guide wire) of the medical wire. As a separating means, a method using an electrolysis method, polyvinyl alcohol (PVA) as a connecting member. For example, a method of fusing and separating the PVA resin using a resin), a method of joining a secondary coil and a guide wire in a screw structure, and removing and separating the screw have been conventionally used.
However, when these conventional separation means are used, the installation of the secondary coil is repeated many times, and therefore, the separation work between the secondary coil and the guide wire requires a great amount of time and labor. This requires time and effort to allow the resin to become familiar with physiological saline in advance, resulting in problems such as prolonged operation time and increased burden on doctors and patients.

また、特許文献１には、上記した従来の分離手段の他に、医療用ワイヤーの接続部材に形状記憶合金を用いて、形状記憶合金を形状変化させて、体内留置具とガイドワイヤーとを分離する方法が記載されており、形状記憶合金を変化させる手段として、熱水を用いる方法および高周波電流を用いる方法が記載されている。
熱水を用いる方法は、例えば脳動脈瘤の治療に医療用ワイヤーが適用される場合、上記した問題に加えて、熱水の注入地点から接続部材に至るまでの距離が長くなり、接続部材に熱水が到達するまでに、熱水の熱が血液に吸収されたりして、熱が冷めるなどの問題があり、また、熱水の温度を上げると生体に影響を及ぼす恐れがあった。
高周波電流を用いる方法は、接続部分だけでなく、体内留置具まで熱されてしまうため、体内留置具周辺の生体組織への侵襲が生じるという問題があった。
また、特許文献１には、接続部材に形状記憶樹脂を用いてもよい旨記載されているが、形状記憶樹脂の形状記憶特性や変形精度が良好でなく、医療用として形状記憶樹脂を用いるにはまだまだ満足のいくものではなかった。
特開平７−２６５４３１号公報 In addition to the conventional separation means described above, Patent Document 1 uses a shape memory alloy as a medical wire connecting member to change the shape of the shape memory alloy to separate the indwelling device from the guide wire. As a means for changing the shape memory alloy, a method using hot water and a method using high-frequency current are described.
In the method using hot water, for example, when a medical wire is applied to the treatment of cerebral aneurysm, in addition to the above problems, the distance from the hot water injection point to the connecting member becomes long, and the connecting member There is a problem that the heat of the hot water is absorbed by the blood before the hot water arrives, and the heat is cooled, and there is a possibility that the living body is affected if the temperature of the hot water is raised.
The method using a high-frequency current has a problem that invasion of living tissue around the indwelling device occurs because not only the connection portion but also the indwelling device is heated.
Further, Patent Document 1 describes that a shape memory resin may be used for the connecting member, but the shape memory characteristics and deformation accuracy of the shape memory resin are not good, and the shape memory resin is used for medical purposes. Was still not satisfactory.
JP-A-7-265431

本発明は、体内留置具の直接加熱による生体組織への侵襲がなく、容易に体内留置具とガイドワイヤーとを分離することができる医療用ガイドワイヤーを提供することを主たる目的とする。   The main object of the present invention is to provide a medical guide wire that can easily separate the indwelling device from the guide wire without invading the living tissue by direct heating of the indwelling device.

本発明者らは、上記目的を達成すべく鋭意検討した結果、体内留置具とガイドワイヤーとの接続部材を形状記憶合金とし、該接続部材の片端に電気絶縁部材を設けて高周波電流による加熱部位を局在化させることにより、体内留置具とガイドワイヤーとを分離する際、体内留置具の加熱による生体組織への侵襲を起こすことなく、容易に体内留置具とガイドワイヤーとを分離することができ、上記した従来の問題を一挙に解決できることを見出し、さらに検討を重ねて本発明を完成させた。   As a result of intensive studies to achieve the above object, the present inventors have made a connection member between the indwelling device and the guide wire a shape memory alloy, and provided an electrical insulating member at one end of the connection member, thereby heating the part by high-frequency current. When the indwelling device and the guide wire are separated, the indwelling device and the guide wire can be easily separated without causing invasion to the living tissue by heating the indwelling device. It was possible to solve the above-mentioned conventional problems all at once, and the present invention was completed through further studies.

すなわち、本発明は、
〔１〕 導電性の線状部材の先端部に電気絶縁部材および接続部材を介して体内留置具が接続されてなり、接続部材が形状記憶合金からなり、線状部材に高周波電流が供給されると接続部材が熱されて変形し、該変形によって体内留置具が切り離されるように構成されたことを特徴とする医療用ワイヤー、
〔２〕 導電性の線状部材の先端部に、順に接続部材、電気絶縁部材および体内留置具が接続されてなることを特徴とする前記〔１〕記載の医療用ワイヤー、
〔３〕 導電性の線状部材の先端部に、順に電気絶縁部材、接続部材および体内留置具が接続されてなることを特徴とする前記〔１〕記載の医療用ワイヤー、
〔４〕 電気絶縁部材が有機高分子樹脂またはセラミックスからなることを特徴とする前記〔１〕〜〔３〕のいずれかに記載の医療用ワイヤー、
〔５〕 体内留置具が血管内留置具である前記〔１〕〜〔４〕のいずれかに記載の医療用ワイヤー、
〔６〕 血管内留置具が二次コイルである前記〔５〕記載の医療用ワイヤー、
〔７〕 動脈瘤、動静脈奇形、動静脈瘻または腫瘍の治療用である前記〔１〕〜〔６〕のいずれかに記載の医療用ワイヤー、
〔８〕 前記〔１〕〜〔７〕のいずれかに記載の医療用ワイヤーとカテーテルとのセット、および
〔９〕 前記〔１〕〜〔７〕のいずれかに記載の医療用ワイヤーを生体内に導入し、ついで高周波電流を医療用ワイヤーの導電性の線状部材に供給することにより、医療用ワイヤーの接続部材が熱されて変形し、該変形によって体内留置具を切り離すことを特徴とする体内留置具の切り離し方法、
に関する。 That is, the present invention
[1] An indwelling device is connected to the distal end portion of a conductive linear member via an electrical insulating member and a connecting member, the connecting member is made of a shape memory alloy, and a high frequency current is supplied to the linear member. And the connecting member is heated and deformed, and the indwelling device is separated by the deformation, the medical wire,
[2] The medical wire according to [1], wherein a connecting member, an electrical insulating member, and an indwelling device are sequentially connected to a distal end portion of the conductive linear member,
[3] The medical wire according to [1], wherein an electrical insulating member, a connecting member, and an indwelling device are connected in order to a distal end portion of the conductive linear member,
[4] The medical wire according to any one of [1] to [3], wherein the electrical insulating member is made of an organic polymer resin or ceramics,
[5] The medical wire according to any one of [1] to [4], wherein the indwelling device is an intravascular indwelling device,
[6] The medical wire according to [5], wherein the intravascular indwelling device is a secondary coil,
[7] The medical wire according to any one of [1] to [6], which is used for treating an aneurysm, arteriovenous malformation, arteriovenous fistula, or tumor,
[8] A set of the medical wire and catheter according to any one of [1] to [7], and [9] The medical wire according to any one of [1] to [7] And then supplying a high-frequency current to the conductive linear member of the medical wire, the connecting member of the medical wire is heated and deformed, and the indwelling device is separated by the deformation. How to remove the indwelling device,
About.

本発明の医療用ガイドワイヤーは、体内留置具の直接加熱による生体組織への侵襲がなく、極めて容易にかつ短時間で体内留置具とガイドワイヤーとを分離することができるため、医者や患者に精神的、肉体的負担を少なくすることができる。   The medical guide wire of the present invention does not invade living tissue due to direct heating of the indwelling device and can separate the indwelling device and the guide wire extremely easily and in a short time. Mental and physical burden can be reduced.

本発明の医療用ワイヤーは、導電性の線状部材の先端部に電気絶縁部材および接続部材を介して体内留置具が接続されてなり、接続部材が形状記憶合金からなり、線状部材に高周波電流が供給されると接続部材が熱されて変形し、該変形によって体内留置具が切り離されるように構成されたことを特徴とする。   In the medical wire of the present invention, an indwelling device is connected to the distal end portion of a conductive linear member via an electrically insulating member and a connecting member, the connecting member is made of a shape memory alloy, and a high frequency is applied to the linear member. When the electric current is supplied, the connecting member is heated and deformed, and the indwelling device is separated by the deformation.

（線状部材）
本発明で使用される線状部材は、導電性の線状部材であれば特に限定されず、公知のものであってよい。このような線状部材の例としては、例えば金属ワイヤー、金属で被覆された線状物などが挙げられ、これらのワイヤーや線状物を絶縁性の樹脂で被覆したものも線状部材として用いてよい。また、これらの線状部材に含まれる金属としては、例えばステンレス鋼、白金、銀、銅、金、マグネシウム、チタン、アルミニウム、ニッケル、これらの合金などが挙げられる。線状部材の外径は、本発明の目的を阻害しない限り特に限定されないが、例えば０．０１〜２．０ｍｍである。線状部材の長さは、目的に応じて種々の長さに設定されるので特に限定されないが、例えば０．１〜１．８ｍである。 (Linear member)
The linear member used in the present invention is not particularly limited as long as it is a conductive linear member, and may be a known member. Examples of such a linear member include, for example, a metal wire, a linear object coated with a metal, and the wire or linear object covered with an insulating resin is also used as the linear member. It's okay. Moreover, as a metal contained in these linear members, stainless steel, platinum, silver, copper, gold | metal | money, magnesium, titanium, aluminum, nickel, these alloys etc. are mentioned, for example. Although the outer diameter of a linear member is not specifically limited unless the objective of this invention is inhibited, For example, it is 0.01-2.0 mm. The length of the linear member is not particularly limited because it is set to various lengths depending on the purpose, but is, for example, 0.1 to 1.8 m.

（電気絶縁部材）
本発明で使用される電気絶縁部材は、電気絶縁性を有していれば特に限定されず、生体に悪影響を与えないものが好ましい。電気絶縁部材の形状や寸法等は本発明の目的を阻害しない限り特に限定されず、接続部材やワイヤーの構成などによって適宜に選択される。電気絶縁部材としては、例えば有機材料、無機材料などが挙げられる。有機材料の種類としては、例えば有機高分子樹脂などが挙げられ、有機高分子樹脂としては、例えば熱可塑性樹脂や熱硬化性樹脂などが挙げられる。無機材料の種類としては、ガラスやセラミックスなどが挙げられる。 (Electrical insulation member)
The electrical insulating member used in the present invention is not particularly limited as long as it has electrical insulating properties, and preferably does not adversely affect the living body. The shape, dimensions, and the like of the electrical insulating member are not particularly limited as long as the object of the present invention is not impaired, and are appropriately selected depending on the configuration of the connecting member and the wire. Examples of the electrical insulating member include organic materials and inorganic materials. Examples of the organic material include organic polymer resins, and examples of the organic polymer resin include thermoplastic resins and thermosetting resins. Examples of the inorganic material include glass and ceramics.

熱可塑性樹脂としては、例えば、ポリエチレンテレフタレート（ＰＥＴ）樹脂等のポリエステル系樹脂や、ポリエチレン（ＰＥ）樹脂、ポリプロピレン（ＰＰ）樹脂等のポリオレフィン系樹脂、スチレン系樹脂、ポリアミド（ＰＡ）系樹脂、ポリカーボネート（ＰＣ）樹脂、ポリメチルメタクリレート（ＰＭＭＡ）樹脂、ポリ塩化ビニル（ＰＶＣ）樹脂、熱可塑性エラストマーなどが挙げられる。
熱硬化性樹脂としては、例えば、フェノール樹脂、エポキシ樹脂、メラミン樹脂、ポリイミド樹脂、不飽和ポリエステル樹脂などが挙げられる。 Examples of the thermoplastic resin include polyester resins such as polyethylene terephthalate (PET) resin, polyolefin resins such as polyethylene (PE) resin and polypropylene (PP) resin, styrene resins, polyamide (PA) resins, and polycarbonates. (PC) resin, polymethyl methacrylate (PMMA) resin, polyvinyl chloride (PVC) resin, thermoplastic elastomer, etc. are mentioned.
Examples of the thermosetting resin include phenol resin, epoxy resin, melamine resin, polyimide resin, unsaturated polyester resin, and the like.

セラミックスとしては、例えば、酸化アルミニウム、窒化アルミニウム、酸化ケイ素 、窒化ケイ素、酸化ジルコン、窒化ボロンなどが挙げられる。ガラスとしては、石英ガラス、ソーダガラス、ホウケイ酸ガラス、鉛ガラスなどが挙げられる。
電気絶縁部材の形状の具体例としては、例えば図１〜５に示す電気絶縁部材４などが挙げられる。 Examples of the ceramic include aluminum oxide, aluminum nitride, silicon oxide, silicon nitride, zircon oxide, and boron nitride. Examples of the glass include quartz glass, soda glass, borosilicate glass, and lead glass.
Specific examples of the shape of the electrical insulating member include, for example, the electrical insulating member 4 shown in FIGS.

（接続部材）
本発明で使用される接続部材は、形状記憶合金からなり、導電性の線状部材に高周波電流が供給されると接続部材が熱されて変形し、該変形によって体内留置具が切り離されるように構成されていれば特に限定されない。また、接続部は、体内留置具とともに電気絶縁部材が切り離されるように構成されていてもよい。形状記憶合金としては、例えばＮｉ−Ｔｉ系合金、Ａｕ−Ｃｄ系合金、Ｃｕ−Ａｌ−Ｎｉ系合金、Ｃｕ−Ａｕ−Ｚｎ系合金、Ｃｕ−Ｚｎ−Ｘ（ＸはＳｉ、Ｓｎ、ＡｌまたはＧａ）系合金、Ｎｉ−Ａｌ系合金、およびＦｅ−Ｐｔ系合金などが挙げられる。これら形状記憶合金の変態点は特に限定されないが、生体内で用いることを考慮して４０〜５０℃程度が好ましい。接続部材の形状の具体例としては、例えば図１〜５に示す接続部材３などが挙げられる。 (Connecting member)
The connection member used in the present invention is made of a shape memory alloy. When a high frequency current is supplied to the conductive linear member, the connection member is heated and deformed, and the indwelling device is separated by the deformation. If it is comprised, it will not specifically limit. Moreover, the connection part may be comprised so that an electrically insulating member may be cut | disconnected with an indwelling device. Examples of the shape memory alloy include a Ni—Ti alloy, an Au—Cd alloy, a Cu—Al—Ni alloy, a Cu—Au—Zn alloy, Cu—Zn—X (where X is Si, Sn, Al, or Ga). ) Based alloys, Ni—Al based alloys, Fe—Pt based alloys and the like. The transformation point of these shape memory alloys is not particularly limited, but is preferably about 40 to 50 ° C. in consideration of use in vivo. Specific examples of the shape of the connecting member include the connecting member 3 shown in FIGS.

（体内留置具）
体内留置具は、本発明の目的を阻害しない限り特に限定されず、公知のものであってよく、これらは用途等によって適宜に選択される。体内留置具としては、例えば血管内留置具などが挙げられ、より具体的には例えば血栓形成部材などが挙げられる。このような体内留置具の好ましい例としては、例えばコイル状物などが挙げられ、より好ましい例としては、二次コイルが挙げられる。金属細線を螺旋状に巻き回してなるのが一次コイルであり、これをさらに、所定の形に巻いたものが二次コイルである。体内留置具の材質としては、生体に害を与えることなく、また、Ｘ線不透過性を有することが好ましく、好適な例としては、金、白金、それらの合金等が挙げられる。 (Indwelling device)
The indwelling device is not particularly limited as long as it does not impair the object of the present invention, and may be a known one, and these are appropriately selected depending on the use and the like. Examples of the indwelling device include an intravascular indwelling device, and more specifically, for example, a thrombus forming member. As a preferable example of such an indwelling device, for example, a coil-like material is exemplified, and a more preferable example is a secondary coil. A primary coil is formed by winding a thin metal wire in a spiral shape, and a secondary coil is obtained by winding the metal wire in a predetermined shape. As a material of the indwelling device, it is preferable that the indwelling device does not harm the living body and has radiopacity, and preferable examples include gold, platinum, and alloys thereof.

（製造方法）
本発明の医療用ワイヤーは、導電性の線状部材の先端部に、電気絶縁部材、接続部材および体内留置具を、常法に従い接続することにより製造される。接続手段は、本発明の目的を阻害しない限り特に限定されず、公知の手段であってよい。接続手段の例としては、例えば、接着剤による接着方法、溶接による方法、物理的連結による方法などの公知の接続手段などが挙げられる。
また、本発明の医療用ワイヤーは、前記の導電性の線状部材の先端部に、前記電気絶縁部材および前記接続部材を介して前記体内留置具が接続されてなるものであるが、前記電気絶縁部材および前記接続部材の接続順序は本発明の目的を阻害しない限り特に限定されず、導電性の線状部材の先端部に、順に電気絶縁部材、接続部材および体内留置具が接続されていてもよいし、順に接続部材、電気絶縁部材および体内留置具が接続されていてもよい。前者の場合には、電気絶縁部材の存在によって、体内留置具ではなく、導電性の線状部材の先端部周囲の体液または組織にて高周波電流による熱が生じ、その熱が接続部材の形状記憶合金へと伝わり、形状記憶合金の変態点以上の温度になると、形状記憶合金の形状変化が起こり、体内留置具が切り離される。後者の場合には、電気絶縁部材の存在によって、体内留置具ではなく、接続部材周囲の体液または組織にて高周波電流による熱が生じ、その熱が接続部材の形状記憶合金の変態点以上になると形状記憶合金が変形し、体内留置具が切り離される。 (Production method)
The medical wire of the present invention is manufactured by connecting an electrically insulating member, a connecting member, and an indwelling device to a distal end portion of a conductive linear member according to a conventional method. The connection means is not particularly limited as long as the object of the present invention is not impaired, and may be a known means. Examples of the connection means include known connection means such as an adhesion method using an adhesive, a welding method, and a physical connection method.
The medical wire of the present invention is formed by connecting the indwelling device to the distal end portion of the conductive linear member via the electrical insulating member and the connecting member. The connection order of the insulating member and the connecting member is not particularly limited as long as the object of the present invention is not hindered, and the electrically insulating member, the connecting member, and the indwelling device are sequentially connected to the distal end portion of the conductive linear member. Alternatively, the connecting member, the electrical insulating member, and the indwelling device may be connected in order. In the former case, due to the presence of the electrical insulation member, heat is generated by high-frequency current in the body fluid or tissue around the tip of the conductive linear member, not in the indwelling device, and this heat is stored in the shape memory of the connection member. When the temperature reaches a temperature equal to or higher than the transformation point of the shape memory alloy, the shape memory alloy changes in shape and the indwelling device is cut off. In the latter case, heat due to high-frequency current is generated in the body fluid or tissue around the connecting member, not the indwelling device, due to the presence of the electrical insulating member, and the heat exceeds the transformation point of the shape memory alloy of the connecting member. The shape memory alloy is deformed and the indwelling device is cut off.

（用途）
本発明の医療用ワイヤーは、血管内治療に用いられ、特に動脈瘤、動静脈奇形、動静脈瘻または腫瘍の治療に用いられる。例えば、本発明の医療用ワイヤーを生体内に導入し、ついで高周波電流を医療用ワイヤーの導電性の線状部材に供給することにより、医療用ワイヤーの接続部材を熱して変形させ、該変形によって体内留置具を切り離すことにより、前記治療が行われ得る。 (Use)
The medical wire of the present invention is used for endovascular treatment, particularly for the treatment of aneurysms, arteriovenous malformations, arteriovenous fistulas or tumors. For example, by introducing the medical wire of the present invention into a living body and then supplying a high frequency current to the conductive linear member of the medical wire, the connecting member of the medical wire is heated and deformed, and the deformation The treatment can be performed by detaching the indwelling device.

より具体的に説明すると、本発明の医療用ワイヤーは、通常、カテーテルとともに用いられ、カテーテルを介して生体内に導入される。例えば、図６に示すように、カテーテル２０を常法に従い生体内に挿入し、体内留置具２を留置すべき個所、この例では脳動脈瘤の個所Ｐに到達させる。図６中の符号２１は、カテーテル２０の手元操作部である。カテーテル２０としては、例えばマイクロカテーテルなどの公知のカテーテルが挙げられる。   More specifically, the medical wire of the present invention is usually used with a catheter and introduced into the living body via the catheter. For example, as shown in FIG. 6, the catheter 20 is inserted into the living body according to a conventional method, and the indwelling device 2 is to be placed, in this example, the place P of the cerebral aneurysm. Reference numeral 21 in FIG. 6 is a hand operating part of the catheter 20. Examples of the catheter 20 include known catheters such as a microcatheter.

本発明の医療用ワイヤーを、体内留置具２を先頭として、手元操作部２１からカテーテル２０内に挿入するとき、体内留置具２が二次コイルである場合、該二次コイルは、カテーテル２０に沿って略直線状に伸びた状態でカテーテル２０内を移動する。そしてカテーテル２０の先端開口から、医療用ワイヤーの体内留置具２を外部に突出させ、接続部材３がカテーテル２０の先端開口部に位置された状態とする。これにより、体内留置具２は、その弾性による復元力で、元の二次コイル体となり、血栓形成部材として作用することができる。   When the medical indwelling device 2 is a secondary coil when the medical wire of the present invention is inserted into the catheter 20 from the hand operating portion 21 with the indwelling device 2 as the head, the secondary coil is connected to the catheter 20. Along the catheter 20, the catheter 20 moves in a substantially straight line. Then, the indwelling device 2 of the medical wire is protruded outside from the distal end opening of the catheter 20, and the connection member 3 is positioned at the distal end opening of the catheter 20. Thereby, the indwelling device 2 becomes an original secondary coil body by the restoring force due to its elasticity, and can act as a thrombus forming member.

そして、図６に示すように、生体２２の適宜の皮膚面にアース電極（対極板）２３を装着した上、導電性の線状部材１の末端部とアース電極２３に高周波電源装置２４を接続し、高周波電流を導電性の線状部材１に供給する。その結果、接続部材３の周囲が熱されるとともに、電気絶縁部材４によって体内留置具２への高周波電流の伝達が遮断されて体内留置具２からの熱発生が起きない。このことにより、体内留置具周辺の血液や生体組織に熱的侵襲を起こすことなく、接続部材３が変形し、体内留置具２が導電性の線状部材１から切り離され、体内留置具２の留置が達成される。
高周波電流は、本発明の目的を阻害しない限り特に限定されず、常法により導電性の線状部材に供給される。このような高周波電流としては、例えば、３５００Ｈｚ以上の高周波電流が挙げられ、とりわけ１００ｋＨｚ〜１ＭＨｚの高周波電流が好ましい。また、高周波電流の供給量は、形状記憶合金の変態点以上の温度を生ぜしめるに充分な量であれば特に限定されない。例えば、高周波電源装置から線状部材に供給される電力は、本発明の目的を阻害しない限り特に限定されないが、好ましくは、０．１〜２０Ｗである。 Then, as shown in FIG. 6, a ground electrode (counter electrode plate) 23 is attached to an appropriate skin surface of the living body 22, and a high frequency power supply device 24 is connected to the terminal portion of the conductive linear member 1 and the ground electrode 23. Then, a high frequency current is supplied to the conductive linear member 1. As a result, the periphery of the connection member 3 is heated, and transmission of high-frequency current to the indwelling device 2 is blocked by the electrical insulating member 4, so that no heat is generated from the indwelling device 2. As a result, the connection member 3 is deformed without causing thermal invasion to blood or living tissue around the indwelling device, and the indwelling device 2 is separated from the conductive linear member 1. Detention is achieved.
The high-frequency current is not particularly limited as long as the object of the present invention is not impaired, and is supplied to the conductive linear member by a conventional method. As such a high-frequency current, for example, a high-frequency current of 3500 Hz or more can be mentioned, and a high-frequency current of 100 kHz to 1 MHz is particularly preferable. Further, the supply amount of the high-frequency current is not particularly limited as long as it is an amount sufficient to generate a temperature equal to or higher than the transformation point of the shape memory alloy. For example, the power supplied from the high frequency power supply device to the linear member is not particularly limited as long as the object of the present invention is not impaired, but is preferably 0.1 to 20 W.

以下、図面を用いて本発明の実施例を説明するが、本発明はこれら実施例に限定されるものではない。   Examples of the present invention will be described below with reference to the drawings, but the present invention is not limited to these examples.

図１を用いて実施例１を説明する。図１（ａ）に示される本発明の医療用ワイヤーは、常法に従い、導電性の線状部材１、接続部材３、電気絶縁部材４および体内留置具２を接続することにより製造される。体内留置具２は二次コイルであり、接続部材３は形状記憶合金からなる押しバネである。また、電気絶縁部材４は接続部材３の金属製筐体に嵌合されていて、この嵌合によって接続部材３と電気絶縁部材４とが接続されている。   Example 1 will be described with reference to FIG. The medical wire of the present invention shown in FIG. 1 (a) is manufactured by connecting a conductive linear member 1, a connecting member 3, an electrical insulating member 4 and an indwelling device 2 according to a conventional method. The indwelling device 2 is a secondary coil, and the connecting member 3 is a push spring made of a shape memory alloy. Further, the electrical insulating member 4 is fitted into the metal casing of the connecting member 3, and the connecting member 3 and the electrical insulating member 4 are connected by this fitting.

導電性の線状部材１に高周波電流を供給することにより、導電性の線状部材１と接続している筐体周囲の体液または組織が熱される。接続部材３は形状記憶合金からなるので、高周波電流によって熱せられた周囲からの熱により接続部材３の形状記憶合金は形状変化を引き起こす。この形状変化によって、図１（ｂ）に示されるように、接続部材３の押しバネが伸び、接続部材３の筐体に嵌合されている電気絶縁部材４が、接続部材の筐体外部へ完全に押し出され、電気絶縁部材４および体内留置具２は、導電性の線状部材１および接続部材３と切り離される。このようにすることにより、体内留置具２へ高周波電流が流れないため、体内留置具周囲の組織は加熱されず、体内留置具周辺の生体組織に熱的侵襲を与えることなく、切り離し作業は容易に行われ、短時間で作業を終了させることができる。   By supplying a high-frequency current to the conductive linear member 1, the body fluid or tissue around the casing connected to the conductive linear member 1 is heated. Since the connecting member 3 is made of a shape memory alloy, the shape memory alloy of the connecting member 3 causes a shape change due to heat from the surroundings heated by the high frequency current. Due to this shape change, as shown in FIG. 1B, the push spring of the connection member 3 is extended, and the electrically insulating member 4 fitted in the housing of the connection member 3 moves to the outside of the housing of the connection member. The electric insulation member 4 and the indwelling device 2 are separated from the conductive linear member 1 and the connection member 3 by being completely pushed out. By doing in this way, since the high frequency current does not flow to the indwelling device 2, the tissue around the indwelling device is not heated, and the separation work is easy without causing thermal invasion to the living tissue around the indwelling device. The operation can be completed in a short time.

図２を用いて実施例２を説明する。図２（ａ）に示される本発明の医療用ワイヤーは、常法に従い、導電性の線状部材１、接続部材３、電気絶縁部材４および体内留置具２を接続することにより製造される。体内留置具２は二次コイルであり、接続部材３は形状記憶合金からなる引きバネである。また、接続部材３の先端部は、電気絶縁部材４に嵌合されていて、この嵌合によって接続部材３と電気絶縁部材４とが接続されている。   A second embodiment will be described with reference to FIG. The medical wire of the present invention shown in FIG. 2 (a) is manufactured by connecting the conductive linear member 1, the connecting member 3, the electrical insulating member 4 and the indwelling device 2 according to a conventional method. The indwelling device 2 is a secondary coil, and the connecting member 3 is a tension spring made of a shape memory alloy. Moreover, the front-end | tip part of the connection member 3 is fitted by the electrical insulation member 4, and the connection member 3 and the electrical insulation member 4 are connected by this fitting.

導電性の線状部材１に高周波電流を供給することにより、導電性の線状部材１に接続している接続部材３の周囲の体液または組織が熱される。接続部材３は形状記憶合金からなるので、高周波電流によって熱せられた周囲からの熱による接続部材３の形状記憶合金は形状変化を引き起こす。この形状変化によって、図２（ｂ）に示されるように、接続部材３の引きバネが縮み、電気絶縁部材４に嵌合されている接続部材３が、接続部材の筐体内部へ完全に収納され、電気絶縁部材４および体内留置具２は、導電性の線状部材１および接続部材３と切り離される。このようにすることにより、体内留置具２へ高周波電流が流れないため体内留置具周囲の組織は加熱されず、体内留置具周辺の生体組織に熱的侵襲を与えることなく、切り離し作業は容易に行われ、短時間で作業を終了させることができる。   By supplying a high-frequency current to the conductive linear member 1, the body fluid or tissue around the connection member 3 connected to the conductive linear member 1 is heated. Since the connection member 3 is made of a shape memory alloy, the shape memory alloy of the connection member 3 caused by heat from the surroundings heated by the high frequency current causes a shape change. Due to this shape change, as shown in FIG. 2B, the pulling spring of the connecting member 3 is contracted, and the connecting member 3 fitted to the electrical insulating member 4 is completely stored inside the housing of the connecting member. Then, the electrical insulating member 4 and the indwelling device 2 are separated from the conductive linear member 1 and the connecting member 3. By doing in this way, since the high frequency current does not flow into the indwelling device 2, the tissue around the indwelling device is not heated, and the separation work can be easily performed without causing thermal invasion to the living tissue around the indwelling device. The work can be completed in a short time.

図３を用いて実施例３を説明する。図３（ａ）に示される本発明の医療用ワイヤーは、常法に従い、導電性の線状部材１、接続部材３、電気絶縁部材４および体内留置具２を接続することにより製造される。体内留置具２は二次コイルであり、接続部材３は形状記憶合金からなり、電気絶縁部材４の球状の先端部が接続部材３に抱持されている。   Example 3 will be described with reference to FIG. The medical wire of the present invention shown in FIG. 3 (a) is manufactured by connecting the conductive linear member 1, the connecting member 3, the electrical insulating member 4 and the indwelling device 2 according to a conventional method. The indwelling device 2 is a secondary coil, the connection member 3 is made of a shape memory alloy, and the spherical tip portion of the electrical insulating member 4 is held by the connection member 3.

導電性の線状部材１に高周波電流を供給することにより、導電性の線状部材１と接続している接続部材３の周囲の体液または組織が熱される。接続部材３は形状記憶合金からなるので、高周波電流によって熱せられた周囲からの熱により接続部材３の形状記憶合金は形状変化を引き起こす。この形状変化によって、図３（ｂ）に示されるように、接続部材３が電気絶縁部材４を抱持できなくなり、電気絶縁部材４および体内留置具２は、導電性の線状部材１および接続部材３と切り離される。このようにすることにより、体内留置具２へ高周波電流が流れないため体内留置具周囲の組織は加熱されず、体内留置具周辺の生体組織に熱的侵襲を与えることなく、切り離し作業は容易に行われ、短時間で作業を終了させることができる。   By supplying a high-frequency current to the conductive linear member 1, the body fluid or tissue around the connection member 3 connected to the conductive linear member 1 is heated. Since the connecting member 3 is made of a shape memory alloy, the shape memory alloy of the connecting member 3 causes a shape change due to heat from the surroundings heated by the high frequency current. Due to this shape change, as shown in FIG. 3B, the connecting member 3 cannot hold the electric insulating member 4, and the electric insulating member 4 and the indwelling device 2 are connected to the conductive linear member 1 and the connecting member. Separated from the member 3. By doing in this way, since the high frequency current does not flow into the indwelling device 2, the tissue around the indwelling device is not heated, and the separation work can be easily performed without causing thermal invasion to the living tissue around the indwelling device. The work can be completed in a short time.

図４を用いて実施例４を説明する。図４（ａ）に示される本発明の医療用ワイヤーは、常法に従い、導電性の線状部材１、接続部材３、電気絶縁部材４および体内留置具２を接続することにより製造される。体内留置具２は二次コイルであり、接続部材３は形状記憶合金からなり、電気絶縁部材４はネジ構造体である。また、接続部材３は、電気絶縁部材４に巻回されていて、係止されている。なお、このときの接続部材３の形状は螺旋状である。   Example 4 will be described with reference to FIG. The medical wire of the present invention shown in FIG. 4 (a) is manufactured by connecting the conductive linear member 1, the connecting member 3, the electrical insulating member 4 and the indwelling device 2 according to a conventional method. The indwelling device 2 is a secondary coil, the connecting member 3 is made of a shape memory alloy, and the electrical insulating member 4 is a screw structure. Further, the connecting member 3 is wound around the electric insulating member 4 and is locked. In addition, the shape of the connection member 3 at this time is a spiral.

導電性の線状部材１に高周波電流を供給することにより、導電性の線状部材１と接続している接続部材３の周囲の体液または組織が熱される。接続部材３は形状記憶合金からなるので、高周波電流によって熱せられた周囲からの熱により接続部材３の形状記憶合金は形状変化を引き起こす。この形状変化によって、接続部材３の形状が螺旋状から直線状または略直線状となり、図４（ｂ）に示されるように、接続部材３は電気絶縁部材４を巻回できなくなり、電気絶縁部材４および体内留置具２は、導電性の線状部材１および接続部材３と切り離される。このようにすることにより、体内留置具２へ高周波電流が流れないため体内留置具周囲の組織は加熱されず、体内留置具周辺の生体組織に熱的侵襲を与えることなく、切り離し作業は容易に行われ、短時間で作業を終了させることができる。   By supplying a high-frequency current to the conductive linear member 1, the body fluid or tissue around the connection member 3 connected to the conductive linear member 1 is heated. Since the connecting member 3 is made of a shape memory alloy, the shape memory alloy of the connecting member 3 causes a shape change due to heat from the surroundings heated by the high frequency current. Due to this shape change, the shape of the connecting member 3 is changed from a spiral to a straight line or a substantially straight line, and as shown in FIG. 4B, the connecting member 3 cannot wind the electric insulating member 4, and the electric insulating member 4 and the indwelling device 2 are separated from the conductive linear member 1 and the connecting member 3. By doing in this way, since the high frequency current does not flow into the indwelling device 2, the tissue around the indwelling device is not heated, and the separation work can be easily performed without causing thermal invasion to the living tissue around the indwelling device. The work can be completed in a short time.

図５を用いて実施例５を説明する。図５（ａ）に示される本発明の医療用ワイヤーは、常法に従い、導電性の線状部材１、電気絶縁部材４、接続部材３および体内留置具２を接続することにより製造される。体内留置具２は二次コイルであり、接続部材３は形状記憶合金からなり、体内留置具２の端部が、接続部材３によって挟持されている。   Example 5 will be described with reference to FIG. The medical wire of the present invention shown in FIG. 5 (a) is manufactured by connecting the conductive linear member 1, the electrical insulating member 4, the connecting member 3 and the indwelling device 2 according to a conventional method. The indwelling device 2 is a secondary coil, the connecting member 3 is made of a shape memory alloy, and the end of the indwelling device 2 is sandwiched by the connecting member 3.

導電性の線状部材１に高周波電流を供給することにより、導電性の線状部材１と接続している接続部材３の周囲の体液または組織が熱される。接続部材３は形状記憶合金からなるので、高周波電流によって熱せられた周囲からの熱により接続部材３の形状記憶合金は形状変化を引き起こす。この形状変化によって、図５（ｂ）に示されるように、接続部材３は電気絶縁部材４を挟持できなくなり、体内留置具２は、導電性の線状部材１、電気絶縁部材４および接続部材３と切り離される。このようにすることにより、体内留置具２へ高周波電流が流れないため体内留置具周囲の組織は加熱されず、体内留置具周辺の生体組織に熱的侵襲を与えることなく、切り離し作業は容易に行われ、短時間で作業を終了させることができる。   By supplying a high-frequency current to the conductive linear member 1, the body fluid or tissue around the connection member 3 connected to the conductive linear member 1 is heated. Since the connecting member 3 is made of a shape memory alloy, the shape memory alloy of the connecting member 3 causes a shape change due to heat from the surroundings heated by the high frequency current. Due to this shape change, as shown in FIG. 5 (b), the connecting member 3 can no longer hold the electric insulating member 4, and the indwelling device 2 includes the conductive linear member 1, the electric insulating member 4, and the connecting member. 3 and separated. By doing in this way, since the high frequency current does not flow into the indwelling device 2, the tissue around the indwelling device is not heated, and the separation work can be easily performed without causing thermal invasion to the living tissue around the indwelling device. The work can be completed in a short time.

本発明の医療用ワイヤーは、血管内治療に有用であり、特に動脈瘤、動静脈奇形、動静脈瘻または腫瘍の治療に有用である。   The medical wire of the present invention is useful for endovascular treatment, and particularly useful for the treatment of aneurysms, arteriovenous malformations, arteriovenous fistulas or tumors.

本発明の実施例１を説明する模式図であって、（ａ）は、体内留置具が二次コイルであり、接続部材が形状記憶合金からなる押しバネであり、電気絶縁部材が接続部材の筐体に嵌合されている場合の医療用ワイヤーを表し、（ｂ）は、高周波電流によって熱せられた接続部材の形状記憶合金の形状変化によって、体内留置具および電気絶縁部材と導電性の線状部材および接続部材とが分離された状態を表す。BRIEF DESCRIPTION OF THE DRAWINGS It is a schematic diagram explaining Example 1 of this invention, Comprising: (a) is an indwelling device is a secondary coil, a connection member is a pushing spring which consists of shape memory alloys, and an electrical insulation member is a connection member. The medical wire in the case of being fitted to the housing is represented, and (b) shows the indwelling device and the electrically insulating member and the conductive wire by the shape change of the shape memory alloy of the connecting member heated by the high frequency current. The state where the shape member and the connection member are separated is shown. 本発明の実施例２を説明する模式図であって、（ａ）は、体内留置具が二次コイルであり、接続部材が引きバネであり、引きバネの先端部が電気絶縁部材に嵌合されている場合の医療用ワイヤーを表し、（ｂ）は、高周波電流によって熱せられた接続部材の形状記憶合金の形状変化によって、体内留置具および電気絶縁部材と導電性の線状部材および接続部材とが分離された状態を表す。It is a schematic diagram explaining Example 2 of this invention, Comprising: (a) is an indwelling device is a secondary coil, a connection member is a tension spring, and the front-end | tip part of a tension spring is fitted to an electrical insulation member (B) shows the indwelling device, the electrical insulating member, the conductive linear member, and the connecting member by the shape change of the shape memory alloy of the connecting member heated by the high-frequency current. Represents a state where and are separated. 本発明の実施例３を説明する模式図であって、（ａ）は、体内留置具が二次コイルであり、接続部材が形状記憶合金からなり、電気絶縁部材の球状の先端部が接続部材に抱持されている場合の医療用ワイヤーを表し、（ｂ）は、高周波電流によって熱せられた接続部材の形状記憶合金の形状変化によって、体内留置具および電気絶縁部材と導電性の線状部材および接続部材とが分離された状態を表す。It is a schematic diagram explaining Example 3 of this invention, Comprising: (a) is an indwelling device is a secondary coil, a connection member consists of shape memory alloys, and the spherical front-end | tip part of an electrically insulating member is a connection member. (B) shows the indwelling device, the electrical insulating member and the conductive linear member due to the shape change of the shape memory alloy of the connecting member heated by the high-frequency current. And a state where the connecting member is separated. 本発明の実施例４を説明する模式図であって、（ａ）は、体内留置具が二次コイルであり、電気絶縁部材がネジであり、接続部材が形状記憶合金からなり、電気絶縁部材のネジ方向に接続部材が巻回されて接続部材と電気絶縁部材とが係止されている場合の医療用ワイヤーを表し、（ｂ）は、高周波電流によって熱せられた接続部材の形状記憶合金の形状変化によって、体内留置具および電気絶縁部材と導電性の線状部材および接続部材とが分離された状態を表す。It is a schematic diagram explaining Example 4 of this invention, Comprising: (a) is an indwelling device is a secondary coil, an electrical insulation member is a screw, a connection member consists of shape memory alloys, and an electrical insulation member Represents a medical wire in the case where the connecting member is wound in the screw direction and the connecting member and the electric insulating member are locked, and (b) shows the shape memory alloy of the connecting member heated by the high-frequency current. This represents a state where the indwelling device and the electrical insulating member are separated from the conductive linear member and the connecting member due to the shape change. 本発明の実施例５を説明する模式図であって、（ａ）は、体内留置具が二次コイルであり、電気絶縁部材が挟持具であり、接続部材が形状記憶合金からなり、接続部材が体内留置具を挟持している場合の医療用ワイヤーを表し、（ｂ）は、高周波電流によって熱せられた接続部材の形状記憶合金の形状変化によって、体内留置具と、導電性の線状部材、電気絶縁部材および接続部材とが分離された状態を表す。It is a schematic diagram explaining Example 5 of this invention, Comprising: (a) is an indwelling device is a secondary coil, an electrical insulation member is a clamping device, a connection member consists of shape memory alloys, and a connection member Represents a medical wire in a case where the indwelling device is sandwiched, and (b) shows the indwelling device and the conductive linear member by the shape change of the shape memory alloy of the connecting member heated by the high-frequency current. This represents a state where the electrical insulating member and the connecting member are separated. 本発明の医療用ワイヤーを生体の脳動脈瘤に適用する場合を説明する模式図である。It is a schematic diagram explaining the case where the medical wire of this invention is applied to a biological cerebral aneurysm.

符号の説明Explanation of symbols

１ 導電性の線状部材
２ 体内留置具（二次コイル）
２ａ 一次コイル
３ 接続部材
４ 電気絶縁部材
２０ カテーテル
２１ 手元操作部
２２ 生体
２３ アース電極
２４ 高周波電源装置
1 Conductive linear member 2 Indwelling device (secondary coil)
2a Primary coil 3 Connection member 4 Electrical insulation member 20 Catheter 21 Hand operation part 22 Living body 23 Ground electrode 24 High frequency power supply device

Claims (9)

導電性の線状部材の先端部に電気絶縁部材および接続部材を介して体内留置具が接続されてなり、接続部材が形状記憶合金からなり、線状部材に高周波電流が供給されると接続部材が熱されて変形し、該変形によって体内留置具が切り離されるように構成されたことを特徴とする医療用ワイヤー。   The indwelling device is connected to the distal end portion of the conductive linear member via an electrical insulating member and a connecting member, the connecting member is made of a shape memory alloy, and when the high frequency current is supplied to the linear member, the connecting member A medical wire, wherein the medical indwelling device is deformed by being heated, and the indwelling device is separated by the deformation. 導電性の線状部材の先端部に、順に接続部材、電気絶縁部材および体内留置具が接続されてなることを特徴とする請求項１記載の医療用ワイヤー。   The medical wire according to claim 1, wherein a connecting member, an electrical insulating member, and an indwelling device are sequentially connected to a distal end portion of the conductive linear member. 導電性の線状部材の先端部に、順に電気絶縁部材、接続部材および体内留置具が接続されてなることを特徴とする請求項１記載の医療用ワイヤー。   The medical wire according to claim 1, wherein an electrically insulating member, a connecting member, and an indwelling device are sequentially connected to a distal end portion of the conductive linear member. 電気絶縁部材が有機高分子樹脂またはセラミックスからなることを特徴とする請求項１〜３のいずれかに記載の医療用ワイヤー。   The medical wire according to any one of claims 1 to 3, wherein the electrical insulating member is made of an organic polymer resin or ceramics. 体内留置具が血管内留置具である請求項１〜４のいずれかに記載の医療用ワイヤー。   The medical wire according to any one of claims 1 to 4, wherein the indwelling device is an intravascular indwelling device. 血管内留置具が二次コイルである請求項５記載の医療用ワイヤー。   The medical wire according to claim 5, wherein the intravascular indwelling device is a secondary coil. 動脈瘤、動静脈奇形、動静脈瘻または腫瘍の治療用である請求項１〜６のいずれかに記載の医療用ワイヤー。   The medical wire according to any one of claims 1 to 6, which is used for treating an aneurysm, arteriovenous malformation, arteriovenous fistula or tumor. 請求項１〜７のいずれかに記載の医療用ワイヤーとカテーテルとのセット。   The set of the medical wire and catheter in any one of Claims 1-7. 請求項１〜７のいずれかに記載の医療用ワイヤーを生体内に導入し、ついで高周波電流を医療用ワイヤーの導電性の線状部材に供給することにより、医療用ワイヤーの接続部材を熱して変形させ、該変形によって体内留置具を切り離すことを特徴とする体内留置具の切り離し方法。
The medical wire according to any one of claims 1 to 7 is introduced into a living body, and then a high frequency current is supplied to the conductive linear member of the medical wire, thereby heating the connecting member of the medical wire. A method for detaching an indwelling device, wherein the indwelling device is deformed and the indwelling device is separated by the deformation.
JP2004377574A 2004-12-27 2004-12-27 Medical wire Pending JP2006181088A (en)

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PCT/JP2005/023351 WO2006070641A1 (en) 2004-12-27 2005-12-20 Wire for medical use

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