JP2006242772A - Reaction container - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a reaction container constituted so as to certainly prevent the evaporation of a content by a simple constitution and suitable from an aspect of miniaturization. <P>SOLUTION: The reaction container is constituted so as to be adapted to an analyzer for analyzing a liquid-containing sample to react the sample with a predetermined reagent and equipped with a container part for holding the sample introduced from the outside through a predetermined opening and the reagent and the lid part, which is combined with the container part, includes at least the opening surface due to the opening with respect to the container part and can slide in a predetermined direction. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a reaction container that is applied to an analyzer that analyzes a sample containing a liquid and holds the sample or the like.

  In an analyzer that analyzes a sample by reacting the sample with a reagent, a technique that can reduce the amount of expensive reagent used by reducing the amount of the sample used for analysis is required in order to reduce running costs. It has been. However, when the liquid component contained in the sample held in the reaction vessel evaporates, the concentration value of the component contained in the sample changes greatly, which hinders accurate analysis.

  In view of the situation described above, conventionally, a technique for preventing evaporation of a liquid component by providing a lid on a reaction vessel has been disclosed (for example, see Patent Document 1). In this technique, a lid having an overhanging portion is coupled to a container body at a pivotal fulcrum such as a hinge, thereby integrating the lid with the container. The lid is opened and closed by hooking or removing a hook-like hook provided in a predetermined lid opening / closing mechanism on the protruding portion of the lid.

  A hangar having a mechanism for holding and sealing the reaction vessel is also known (see, for example, Patent Document 2). In this hangar, an inner lid is provided on the inner side of the front lid, and the inner lid is moved up and down by a spring to seal or open the opening of the reaction container accommodated in the hangar.

JP-A-8-94624 JP 2003-215134 A

  By the way, when the sample is made in a very small amount, it is more preferable that the reaction vessel is also downsized. However, since the reaction vessel described in Patent Document 1 includes members such as an overhang portion and a rotation fulcrum as a part of the lid structure, the configuration is complicated and it is difficult to reduce the size. It was.

  Moreover, in the technique described in Patent Document 2, it is necessary to provide a complicated function for opening and closing the lid on the side where the reaction vessel is stored, and it is difficult to apply to a small reaction vessel. .

  The present invention has been made in view of the above, and an object of the present invention is to provide a reaction container that can reliably prevent evaporation of contents with a simple structure and is suitable for miniaturization.

  In order to solve the above-described problems and achieve the object, the invention described in claim 1 is a reaction container that is applied to an analyzer that analyzes a sample containing a liquid and that reacts the sample with a predetermined reagent. A container portion for holding a sample and a reagent introduced from the outside through a predetermined opening; and a predetermined direction including at least an opening surface of the container relative to the container portion. And a slidable lid.

  According to a second aspect of the present invention, in the first aspect of the invention, the container portion emits light to analyze a sample, a reagent, or a reaction solution of the sample and the reagent held in the container portion. It has the light irradiation area | region to irradiate, It is characterized by the above-mentioned.

  According to a third aspect of the present invention, in the first aspect of the present invention, the state where the lid portion is reached by sliding with respect to the container portion includes a state where the lid portion shields the opening from the outside. It is characterized by that.

  According to a fourth aspect of the present invention, in the first aspect of the invention, the state where the lid portion is reached by sliding with respect to the container portion includes a state where the opening is exposed to the outside. And

  The invention according to claim 5 is the invention according to claim 1, further comprising guiding means for guiding a slide of the lid portion with respect to the container portion.

  The invention according to claim 6 is the invention according to claim 1, further comprising a restricting means for restricting a sliding amount of the lid part with respect to the container part.

  The invention according to claim 7 is the invention according to claim 1, further comprising a dispensing unit that measures the sample to a predetermined volume and introduces the measured sample into the container. .

  The invention according to claim 8 is the invention according to claim 7, wherein the dispensing unit introduces the sample and measures the sample to a predetermined volume, and discharges the sample measured by the metering unit to the outside. A discharge portion that discharges the sample to the container portion by applying a predetermined pressure to the sample introduced into the measuring portion.

  A ninth aspect of the invention is characterized in that, in the seventh aspect of the invention, the dispensing part is provided on the lid part.

  The invention according to claim 10 is the invention according to claim 7, wherein the dispensing part is provided in the container part.

  According to the present invention, a container part that holds a sample and a reagent introduced from the outside through a predetermined opening and the container part are combined, and the container part is placed on an opening surface by the opening. By providing at least a lid portion that can be slid in a predetermined direction, it is possible to reliably prevent evaporation of the contents with a simple configuration and to provide a reaction container that is suitable for miniaturization.

  The best mode for carrying out the present invention (hereinafter referred to as an embodiment) will be described below with reference to the accompanying drawings.

(Embodiment 1)
FIG. 1 is a perspective view showing a configuration of a reaction vessel according to Embodiment 1 of the present invention. The reaction container 1 shown in the figure includes a container part 11 for holding a sample and a reagent introduced from the outside, and a lid part 12 disposed above the container part 11 and slidable in a predetermined one-dimensional direction. .

  The container part 11 is provided with the flat base part 11a and the protrusion part 11b which protrudes in the direction orthogonal to the bottom face of this base part 11a. One side surface (side surface parallel to the xz plane in FIG. 1) of the container portion 11 has a convex shape, and is along a direction (y-axis direction in FIG. 1) perpendicular to the side surface forming the convex shape. Has a uniform outer shape. The protruding portion 11b is provided with a holding portion 13 that holds a sample and a reagent and reacts the sample and the reagent. The holding portion 13 has a square opening parallel to the upper end surface of the protruding portion 11b, and the inside of the holding portion 13 forms a rectangular parallelepiped space. The reaction result between the sample and the reagent in the holding unit 13 is optically measured by transmitting predetermined light through the holding unit 13. For this reason, the container part 11 and the cover part 12 are implement | achieved using transparent resin or glass which permeate | transmits light.

  The lid portion 12 includes a flat main plate portion 12a, and side plate portions 12b and 12c extending from the opposing ends of the main plate portion 12a in a direction perpendicular to the main plate portion 12a. One side surface (side surface parallel to the xz plane in FIG. 1) of the lid portion 12 has a concave shape that can be fitted to the side surface forming the convex shape of the container portion 11. Moreover, the cover part 12 has a uniform external shape along the direction (y-axis direction of FIG. 1) orthogonal to the side surface which makes the concave shape.

  The lid portion 12 is provided with a dispensing portion 14 for introducing a sample into a holding portion 13 provided in the container portion 11. FIG. 2 is a diagram showing a detailed configuration of the dispensing unit 14, and is a partial longitudinal sectional view taken along line AA when the vicinity of the dispensing unit 14 in FIG. 1 is cut in the vertical direction (z-axis direction in FIG. 1). It is. The dispensing unit 14 includes a liquid holding unit 141 that holds a small amount of a sample containing a liquid, a weighing unit 142 that performs sample weighing, and a bottom surface of the weighing unit 142 to a side surface opposite to a side surface on which the weighing unit 142 is provided. A discharge portion 143 that is penetrated, and a flow path 144 that connects the liquid holding portion 141 and the measuring portion 142 are provided.

  The measuring unit 142 measures the sample introduced from the liquid holding unit 141 via the flow path 144 to a predetermined volume. In addition, since the discharge unit 143 has a smaller diameter than that of the measuring unit 142, the flow path resistance is large, and the discharge unit 143 can be used even when a pressure of about normal atmospheric pressure is applied to the liquid level of the sample introduced into the measuring unit 142. The sample is not discharged from 143. In addition, you may give hydrophobicity by apply | coating hydrophobic resin (for example, polyfluorinated ethylene, polytetrafluoroethylene) etc. to the inner wall face of the discharge part 143. FIG.

  In the dispensing unit 14 having the above configuration, the sample introduced into the liquid holding unit 141 is introduced into the measuring unit 142 from the flow path 144 by capillary force. Thereafter, by applying a pressure significantly larger than the atmospheric pressure from the outside to the liquid level of the sample introduced into the measuring unit 142, the sample accurately measured by the measuring unit 142 is discharged from the discharge unit 143. . When applying pressure for discharging the sample to the measuring unit 142, for example, a space above the measuring unit 142 is covered, and a pulsed air pressure significantly larger than atmospheric pressure is generated in the covered space. Just do it.

  After that, when the pressure applied from above the measuring unit 142 is released and returned to the atmospheric pressure state, a part of the sample in the liquid holding unit 141 is introduced again into the measuring unit 142 that has been emptied through the channel 144. The Thereafter, by repeating the series of operations described above while additionally introducing the sample into the liquid holding unit 141, the sample of the volume of an arbitrary integral multiple of the basic unit is discharged with the volume of the measuring unit 142 as the basic unit. It can be discharged from the portion 143 to the holding portion 13. In such a dispensing unit 14, since the discharge amount is strictly measured when the sample is introduced into the measuring unit 142, when the sample is introduced into the liquid holding unit 141, it overflows from the liquid holding unit 141. A rough amount should be introduced.

  The volume of the measuring unit 142 is at most about several ml (milliliter), more preferably several hundred μl (about microliter), and further preferably about several tens to several hundred nl (nanoliter). As described above, the reaction container 1 is assumed to be applied to an analyzer for analyzing a small amount of specimen sample. The size of the reaction vessel 1 in this case is such that the length of one side is about several millimeters (millimeters) to several centimeters (centimeters).

  The configuration of the dispensing unit 14 described above is merely an example. For example, the dispensing unit can be configured by the measuring unit 142 and the discharge unit 143 without providing the liquid holding unit 141 and the channel 144. It is. Further, the shape of each part of the dispensing unit is not limited to that shown in FIG. 2, but is arbitrary.

FIG. 3 is a perspective view showing a state in which the reaction vessel 1 is assembled by fitting the vessel portion 11 and the lid portion 12. More specifically, the lid portion 12 is placed in a container so that the upper end surface of the protruding portion 11b and the side surface (inner side surface) of the side surface of the main plate portion 12a of the lid portion 12 on which the side plate portions 12b and 12c extend are in contact. FIG. 6 is a perspective view showing a state in which it is placed on a protruding part 11b of a part 11. FIG. 4 is a side view in the direction of arrow B in FIG. As is clear from FIGS. 3 and 4, the lid 12 is in relation to the container 11 in a state in which the container 11 and the lid 12 are fitted to assemble the reaction container 1 (fitted state). The length L ₁₁ of the container part 11 in the direction parallel to the sliding direction (y-axis direction in FIG. 4) is longer than the length L ₁₂ of the lid part 12 in the same direction (L ₁₁ > L ₁₂ ).

  Incidentally, in the state shown in FIGS. 3 and 4, the lid 12 is not located on the opening surface of the holding unit 13. Therefore, in this state, the reagent can be introduced into the holding unit 13 from above the holding unit 13 through the opening. Thus, the formation position of the holding part 13 is determined depending on the size of the container part 11 (particularly the protruding part 11b) and the lid part 12.

  FIG. 5 is a diagram illustrating another state that can be reached by sliding the lid 12 in the positive y-axis direction from the state illustrated in FIGS. 3 and 4. More specifically, FIG. 5 is a diagram showing a case where alignment is performed by sliding the lid portion 12 so that the side surfaces opposite to those in FIG. 4 are on the same plane. In the case shown in FIG. 5, the lower end of the discharge part 143 is located immediately above the opening surface of the holding part 13. Therefore, in this state, by applying a pressure significantly higher than the atmospheric pressure to the liquid level of the sample introduced into the measuring unit 142, the sample accurately measured by the measuring unit 142 is discharged to the holding unit 13.

  When the sample is discharged in the state shown in FIG. 5, a reaction occurs with the reagent that has already been introduced into the holding unit 13. When analyzing the sample using the result of this reaction, the light irradiation region T provided below the holding unit 13 is irradiated with predetermined light by a laser diode or the like, and the irradiated light is held by the holding unit 13. The light transmitted through the reaction solution is received by a photodiode or the like, thereby measuring the absorbance of the reaction solution obtained by the reaction between the sample and the reagent. Thereafter, the analyzer performs an analysis operation of the sample components based on the measurement result.

  In order to accurately measure the absorbance of the reaction solution, the side surface including the light irradiation region T of the projecting portion 11 b must be parallel to the inner side surface of the holding portion 13. Moreover, it is preferable that the side plate portions 12 b and 12 c have such a length that does not extend to the light irradiation region T of the container portion 11 when the container portion 11 and the lid portion 12 are assembled and assembled. In addition, you may implement | achieve only this light irradiation area | region T among the container parts 11 by materials, such as quartz with high transmittance | permeability.

  Although the opening surface of the holding portion 13 after the sample is discharged is connected to the outside air via the tip of the discharge portion 143, since the diameter of the discharge portion 143 is very small, there is little influence from the outside. In particular, if the sample flowing out to the measuring unit 142 via the flow path 144 remains in the liquid holding unit 141, the sample is again introduced into the measuring unit 142 by releasing the pressure after discharging the sample. The 13 openings are completely shielded from the outside. As a result, the evaporation of the liquid component held by the holding unit 13 can be prevented, and the sample can be analyzed with higher accuracy.

  According to the first embodiment of the present invention described above, a container part that holds a sample and a reagent introduced from the outside through a predetermined opening, and the container part are combined, and the container part And a lid that is slidable in a predetermined direction including at least the opening surface of the opening, thereby reliably preventing evaporation of the contents with a simple configuration and suitable for miniaturization. Can be provided.

  Further, according to the first embodiment, by providing the dispensing part on the lid part, it is possible to accurately perform relative positioning with the dispensing part at the time of sample dispensing with a simple configuration. It becomes.

  Conventionally, when realizing miniaturization of a reaction vessel with a small amount of a sample, a problem of how to clean the reaction vessel after use has always occurred. As a measure to solve this problem, it is conceived that the reaction vessel is made disposable. However, the more complicated the shape of the reaction vessel, the more expensive it is to create, so a new problem arises of being uneconomical. It was a result. The reaction container according to the first embodiment has a simple configuration that can be assembled by fitting concave and convex shapes, so that the manufacturing cost can be kept low, and it is also suitable for use in a disposable form. Therefore, it is possible to provide a reaction container that can perform a highly accurate analysis while reducing the amount of the sample at a low cost.

(Modification of Embodiment 1)
FIG. 6 is a diagram showing an outline of a modification of the reaction container according to Embodiment 1, and is a side view (in the xz plane) in the direction of arrow C in FIG. 2 when the reaction container is assembled. It is a figure equivalent to a parallel side surface. The reaction container 110 shown in FIG. 6 includes a container part 111 and a lid part 112. Among these, the container part 111 is provided with the flat base part 111a and the protrusion part 111b which protrudes in the direction substantially orthogonal to the bottom face of this base part 111a. The side surface of the protruding portion 111b that fits with the lid portion 112 has an inversely tapered shape that becomes wider as it goes upward (in the + z direction in FIG. 6).

  On the other hand, the lid portion 112 includes a flat main plate portion 112a, and side plate portions 112b and 112c extending from each of opposing ends of the main plate portion 112a in a direction orthogonal to the main plate portion 112a. The inner side surfaces of the main plate portion 112a and the side plate portions 112b and 112c have a dovetail shape that can be fitted to the reverse tapered shape of the protrusion 111b described above.

  When the reaction vessel 110 is assembled by combining the vessel portion 111 and the lid portion 112, the dovetail portion of the lid portion 112 is aligned with the reverse tapered portion of the protruding portion 111 b of the vessel portion 111, and the lid portion 112. Is fitted into the container 111 while sliding in the y-axis direction.

  In addition, the structure of the holding | maintenance part 113 which the container part 111 has, and the dispensing part 114 provided in the cover part 112 are the same as the holding | maintenance part 13 of the reaction container 1 mentioned above, and the dispensing part 14, respectively. Therefore, sample dispensing and reagent introduction into the holding unit 113 may be performed in the same manner as in the reaction vessel 1.

  According to the reaction vessel 110 having the above configuration, the fitting portion between the vessel portion 111 and the lid portion 112 serves as a guiding means that guides the sliding direction of the lid portion 112 with respect to the vessel portion 111 in a predetermined one-dimensional direction. Therefore, the container part 111 and the cover part 112 can be connected more reliably. As a result, for example, even when a force upward in the vertical direction (+ z direction) in FIG. 6 acts on the lid portion 112, the lid portion 112 does not move away from the container portion 111. Will also increase. In particular, when the lid part 112 has the dispensing part 114, it is possible to prevent the introduced sample from leaking to the outside, which is more preferable.

  FIG. 7 is a diagram showing an outline of another modification of the reaction vessel according to the first embodiment, and is a side view seen from the same direction as FIG. 6 (corresponding to the direction of arrow C in FIG. 2). is there. A reaction vessel 120 shown in FIG. 7 includes a vessel portion 121 and a lid portion 122 that are substantially the same as the reaction vessel 1. Among these, the side surface of the protruding portion 121b of the container portion 121 protrudes minutely in parallel and uniformly along the direction in which the lid portion 122 slides in the assembled state of the reaction vessel 120 (y-axis direction in FIG. 7). A guide portion 125 is provided. On the other hand, a groove portion 126 into which the guide portion 125 can be fitted is provided on the inner surface of the lid portion 122 in parallel and uniformly along the sliding direction. Therefore, in this reaction container 120, the guide part 125 and the groove part 126 are combined to form at least a part of the guiding means.

  According to the reaction vessel 120 having the above configuration, the same effects as those of the reaction vessel 110 according to the modified example of the first embodiment described above can be obtained. Also in the case of this reaction vessel 120, the configurations of the holding unit 123 and the dispensing unit 124 are the same as the configurations of the holding unit 13 and the dispensing unit 14 in the reaction vessel 1, respectively.

(Embodiment 2)
FIG. 8 is a perspective view showing the configuration of the reaction vessel according to Embodiment 2 of the present invention. The reaction container 2 shown in the figure includes a container part 21 that holds a sample and a reagent introduced from the outside, and a lid part 22 that is arranged above the container part 21 and that can slide in a predetermined one-dimensional direction. .

  The container portion 21 includes a flat pedestal portion 21a and a protruding portion 21b that protrudes in a direction orthogonal to the bottom surface of the pedestal portion 21a. One side surface (side surface parallel to the xz plane in FIG. 8) of the container portion 21 has a convex shape, and along a direction (y-axis direction in FIG. 8) perpendicular to the side surface forming the convex shape. Make a uniform outer shape. A holding part 23 that holds a sample and a reagent and reacts the sample and the reagent is provided at a substantially central part of the protruding part 21b. The holding portion 23 has a square opening parallel to the upper end surface of the protruding portion 21b, and the inside of the holding portion 23 forms a rectangular parallelepiped space. Also in the second embodiment, in order to optically measure the reaction result between the sample and the reagent in the holding unit 23, the container unit 21 and the lid unit 22 are realized using a transparent resin or glass.

  The lid portion 22 includes a flat main plate portion 22a, and side plate portions 22b and 22c extending from the opposing ends of the main plate portion 22a in a direction orthogonal to the main plate portion 22a. One side surface (side surface parallel to the xz plane in FIG. 8) of the lid portion 22 has a concave shape that can be fitted to the side surface forming the convex shape of the container portion 21. Moreover, the cover part 22 has a uniform external shape along the direction (y-axis direction of FIG. 8) orthogonal to the side surface which makes the concave shape.

  The lid portion 22 is provided with a dispensing portion 24 for introducing a sample into the holding portion 23 and an opening portion 25 having a cross section substantially the same shape as the opening surface of the holding portion 23 and penetrating the main plate portion 22a. Yes. Among these, the dispensing unit 24 includes a liquid holding unit 241, a measuring unit 242, a discharge unit 243, and a flow path 244, similarly to the dispensing unit 14 described in the first embodiment. The operation of the dispensing unit 24 during dispensing is the same as the operation of the dispensing unit 14 during dispensing.

  FIG. 9 is a view showing a state in which the reaction vessel 2 is assembled by fitting the container portion 21 and the lid portion 22 having the above-described configuration, and is a longitudinal sectional view taken along the line DD in FIG. As is clear from FIG. 9, the direction in which the lid 22 slides relative to the container 21 in a state where the container 21 and the lid 22 are fitted to assemble the reaction container 2 (fitted state). The length of the container portion 21 and the length of the lid portion 22 in the direction parallel to (the y-axis direction in FIG. 9) are equal.

  In the state shown in FIG. 9, that is, the side surface forming the convex shape of the container portion 21 and the side surface forming the concave shape of the lid portion 22 are aligned on the same plane, the opening of the holding portion 23 is the main plate of the lid portion 22. The part 22a is completely shielded from the outside. Therefore, if the reagent is stored in the state shown in FIG. 9 after being introduced into the holding unit 23, evaporation of the liquid component of the reagent can be prevented. Furthermore, if the container portion 21 and the lid portion 22 are bonded and fixed in the state shown in FIG. 9, in addition to evaporation of the liquid component held in the holding portion 23 when the reaction vessel 2 is transported or stored, the container portion 21 and the lid portion 22 are exposed to the outside. Liquid leakage can also be prevented.

  FIG. 10 is a view showing the positional relationship between the container part 21 and the lid part 22 when the reagent is introduced from above the opening part 25 provided in the lid part 22 into the holding part 23, and has the same cut surface as FIG. FIG. FIG. 10 shows a state where positioning is performed by sliding the lid portion 22 in the negative y-axis direction (leftward in FIG. 10) from the state shown in FIG. In this state, since the opening 25 is located above the opening surface of the holding unit 23, the reagent can be introduced into the holding unit 23 from above the opening 25 without removing the lid 22.

  FIG. 11 is a diagram showing a positional relationship between the container part 21 and the lid part 22 when the sample is discharged to the holding part 23 by the dispensing part 24, and is a cross-sectional view seen from the same cut surface as FIG. FIG. 11 shows a state when positioning is performed by sliding the lid portion 22 in the positive y-axis direction (rightward in FIG. 11) from the state shown in FIG. In this state, when a predetermined sample is introduced into the liquid holding unit 241 of the dispensing unit 24, the sample flows into the measuring unit 242 by the capillary force acting in the flow path 344, and a predetermined volume of the sample is measured. Thereafter, by applying a pressure significantly larger than the sample atmospheric pressure introduced into the measuring unit 242, the sample accurately measured by the measuring unit 242 is discharged from the discharge unit 243 to the holding unit 23.

  According to the second embodiment of the present invention described above, it is possible to provide a reaction container suitable for the purpose of reliably preventing evaporation of the contents with a simple configuration and reducing the size. Further, by providing the dispensing part on the lid part, it is possible to accurately perform the relative positioning with the dispensing part at the time of sample dispensing with a simple configuration. As a result, it is possible to provide a reaction container that can perform highly accurate analysis while reducing the amount of the sample in a low cost.

  Further, according to the second embodiment, the introduction of the reagent is further facilitated by providing the lid with the opening having the same shape as the opening of the holding part.

  Furthermore, according to the second embodiment, the length of the lid portion in the direction parallel to the sliding direction is the same between the container portion and the lid portion in the assembled state of the reaction vessel, so that the opening of the holding portion is blocked. In this state, the side surfaces of the container portion and the lid portion can be matched, and handling becomes easier. In addition, since the opening of the holding part can be completely shielded from the outside according to the position of the lid part, it prevents evaporation of the liquid component of the reagent after introduction of the reagent and prevents liquid leakage after the reaction. It becomes possible to do.

(Modification of Embodiment 2)
FIG. 12 is a diagram showing a modification of the second embodiment, and is a longitudinal sectional view corresponding to FIG. 9 which is a longitudinal sectional view of the reaction vessel 2 described above. A reaction vessel 201 shown in FIG. 12 includes the above-described vessel portion 21 and a lid portion 221 that is disposed above the vessel portion 21 and is slidable along the horizontal longitudinal direction (y-axis direction in the drawing) of the protruding portion 21b. With. The lid part 221 has a dispensing part 24 and an opening part 25 in the same manner as the lid part 22 described above.

  As is clear from FIG. 12, in the state where the reaction vessel 201 is assembled by fitting the container portion 21 and the lid portion 221, the length of the protruding portion 21 b in the horizontal longitudinal direction is the length of the lid portion 221 in the same direction. Although longer than this, the opening of the holding portion 23 can be shielded from the outside by sliding the lid portion 221 to an appropriate position (the state shown in FIG. 12). Therefore, similarly to the lid part 22 described above, drying in the holding part 23 can be suppressed to prevent evaporation of the liquid component of the reagent and to prevent leakage of the reaction liquid after the reaction.

  FIG. 13 is a view showing another modification of the second embodiment, and is a longitudinal sectional view having the same cut surface as FIG. A reaction vessel 202 shown in FIG. 13 includes a vessel portion 21 and a lid portion 222 in which the length in the horizontal longitudinal direction of the protruding portion 21b is shorter than the lid portion 221 described above in the fitted state. The opening part is not formed in the cover part 222. For this reason, when introducing the reagent into the holding part 23, the cover part 222 is slid to expose the holding part 23, but the opening of the holding part 23 after the reaction can be shielded from the outside ( State of FIG. 13). Therefore, in this case, the same effect as that of the reaction vessel 201 can be obtained.

  FIG. 14 is a longitudinal sectional view showing an outline of still another modified example of the second embodiment, and is a longitudinal sectional view having the same cut surface as FIG. The reaction vessel 203 shown in FIG. 14 includes a vessel portion 213 and a lid portion 223 as with the above-described reaction vessels. In the case of this reaction vessel 203, the length of one side of the square that forms the opening surface of the holding portion 233 provided in the vessel portion 213 is relatively large with respect to the horizontal width of the vessel portion 213. Even if it is slid and aligned, the opening cannot be completely shielded from the outside.

  In such a case, as shown in FIG. 15, the opening of the holding part 233 is shielded from the outside by covering the upper part of the dispensing part 24 including the measuring part 242 with the liquid L having an appropriate viscosity. Also good. Further, as shown in FIG. 16, the opening of the holding portion 233 may be shielded from the outside by sticking a shielding sheet S on the upper surface of the lid portion 223.

(Embodiment 3)
FIG. 17 is a perspective view showing a configuration of a reaction vessel according to Embodiment 3 of the present invention. The reaction container 3 shown in the figure includes a container part 31 that holds a sample and a reagent introduced from the outside, and a lid part 22 that is arranged above the container part 31 and that can slide in a predetermined one-dimensional direction. . Among these, the lid part 22 is the same as that described in the second embodiment, and the dispensing part 24 (having the liquid holding part 241, the measuring part 242, the discharge part 243, and the flow path 244) and the opening part 25. And have.

  The container part 31 has the same outer shape as the container part 21 described above, and includes a flat pedestal part 31a and a protruding part 31b that protrudes in a direction perpendicular to the bottom surface of the pedestal part 31a. The protruding portion 31b is provided with a holding portion 33 having a square opening. In addition, a groove portion 36 having a diameter that is significantly smaller than the length of one side of the square that forms the opening surface of the holding portion 33 is formed in the upper end surface of the protruding portion 31b. The groove portion 36 extends from the opening surface of the holding portion 33 to one of the two side surfaces having a convex shape, and in the state where the reaction vessel 3 is assembled by fitting the lid portion 22, A hole for connecting the holding portion 33 and the outside is formed. This hole is used for venting to release a part of the air inside the holding unit 33 to the outside of the reaction vessel 3 when the sample introduced into the dispensing unit 24 is discharged to the holding unit 33 via the discharge unit 243. It functions as a flow path.

  In the state where the reaction vessel 3 is assembled, the length in the horizontal longitudinal direction (y-axis direction in FIG. 17) of the protruding portion 31b of the vessel portion 31 and the length in the same direction of the lid portion 22 may be the same. The length of the lid portion 22 may be shorter. Among these, as shown in FIG. 17, when the container part 31 and the cover part 22 have the same length in the y-axis direction, the side surface forming the convex shape of the container part 31 and the side surface forming the concave shape of the cover part 22 Are aligned on the same plane (the initial state), the opening of the holding portion 33 is shielded from the outside by the main plate portion 22a.

  Moreover, the groove part 36 does not necessarily need to be a straight line, and may be a curved line. Further, instead of providing the groove portion 36, a hole portion having a diameter similar to the depth of the groove portion 36 is formed from the side wall of the holding portion 33 on the side surface of the convex shape parallel to the xz plane in FIG. The portion may be a flow path for air bleeding. When forming such a hole, it is more preferable to form the hole at a position as close to the upper end surface of the protruding portion 31b as possible so that a sample and a reagent are not mixed.

  According to the third embodiment of the present invention described above, evaporation of contents can be reliably prevented with a simple configuration, and a reaction container suitable for miniaturization can be provided. By providing the lid, relative positioning with the dispensing unit during sample dispensing can be performed accurately with a simple configuration. As a result, it is possible to provide a reaction container that can perform highly accurate analysis while reducing the amount of the sample in a low cost.

  Further, according to the third embodiment, by providing a hole portion that spatially connects the holding portion and the outside of the reaction vessel, a part of the air in the holding portion is moved to the outside of the reaction vessel when dispensing the sample. The sample can be discharged and the sample can be dispensed more reliably and smoothly.

(Modification of Embodiment 3)
FIG. 18 is a top view showing the configuration of the lid of the reaction vessel according to a modification of the third embodiment, and FIG. 19 is a side view in the direction of arrow E in FIG. The lid part 32 shown in these drawings has a dispensing part 34 (having a liquid holding part 341, a measuring part 342, a discharge part 343, and a flow path 344) having the same configuration as the dispensing part 24 and the opening part 25, respectively. In addition to the opening 35, a groove 361 is provided. The groove portion 361 faces the groove portion 36 provided in the container portion 31 when the lid portion 32 is slid and positioned with respect to the container portion 31 in discharging the sample from the discharge portion 343 of the dispensing portion 34. It forms so that it may become a position, and it makes | forms the hole which connects the holding | maintenance part 33 and the exterior together with the groove part 36. FIG. In addition, when using this cover part 32, it is not necessary to provide the groove part 36 in the container part side. That is, you may apply the container part 21 of the reaction container 2 which concerns on the said Embodiment 2. FIG.

  FIG. 20 is a top view showing the configuration of the lid of the reaction container according to another modification of the third embodiment. In the lid portion 37 shown in the figure, a groove portion 362 is provided between the measuring portion 342 of the dispensing portion 34 and the opening portion 35, and one end portion of the groove portion 362 reaches the opening portion 35. When the lid portion 37 having such a configuration is used, when the sample is ejected from the ejection portion 343, the air in the holding portion 33 passes through the groove portion 362 that forms a hole with the lid portion 37, thereby opening the opening portion. 35 is released to the outside. Therefore, as in the case of the lid part 32, it is not necessary to provide a groove part on the container part side. In this sense, the container part 21 or the container part 31 may be used as the container part.

  Needless to say, the reaction container according to the modification of the third embodiment described above has the same effects as those of the third embodiment.

(Embodiment 4)
FIG. 21 is a perspective view showing the configuration of the reaction vessel according to Embodiment 4 of the present invention. The reaction container 4 shown in the figure includes a container part 41 that holds a sample and a reagent introduced from the outside, and a lid part 42 that is disposed above the container part 41 and that can slide in a predetermined one-dimensional direction. .

  The container part 41 has the same outer shape as the container part 21 described above, and includes a flat pedestal part 41a and a protruding part 41b that protrudes in a direction perpendicular to the bottom surface of the pedestal part 41a. The protruding portion 41b is provided with a holding portion 43 having a square opening. Further, the container portion 41 is provided with a hole portion 461 penetrating from the side surface of the holding portion 43 to one side surface of the protruding portion 41b. In the case shown in FIG. 21, the penetration direction of the hole 461 is a direction (x-axis direction in FIG. 21) orthogonal to the direction in which the lid part 42 slides with respect to the container part 41 in a state where the reaction container 4 is assembled. .

  The lid portion 42 includes a flat main plate portion 42a, and side plate portions 42b and 42c extending from the opposing end portions of the main plate portion 42a in a direction orthogonal to the main plate portion 42a. The outer shape is the same as that of the portion 22. A sample is introduced into the lid 42, a dispensing part 44 for discharging the introduced sample to the holding part 43, and a cross-section substantially the same shape as the opening surface of the holding part 43, and penetrates the main plate part 42 a. An opening 45 is provided. Among these, the dispensing unit 44 includes a liquid holding unit 441, a metering unit 442, a discharge unit 443, and a flow path 444, similar to the dispensing unit 14 described in the first embodiment.

  Further, in one side plate portion (side plate portion 42b in the case of FIG. 21) of the lid portion 42, a direction orthogonal to the direction in which the lid portion 42 slides with respect to the vessel portion 41 in a state where the reaction vessel 4 is assembled. A hole portion 462 that is penetrated in the x-axis direction of FIG. 21 is provided. The diameter of the hole 462 is the same as the diameter of the hole 461 of the container 41.

  FIG. 22 is a side view in the direction of arrow F in FIG. 21 in a state where the reaction container 4 is assembled by fitting the container 41 and the lid 42 having the above configuration. As shown in FIG. 22, in a state in which the reaction container 4 is assembled by fitting the container portion 41 and the lid portion 42 (fitted state), the lid portion 42 is parallel to the direction in which the lid portion 42 slides with respect to the container portion 41. The length of the container portion 41 and the length of the lid portion 42 in the same direction (y-axis direction in FIG. 22) are equal. Further, in the state shown in FIG. 22, that is, in a state where the side surface forming the convex shape of the container part 41 and the side surface forming the concave shape of the lid part 42 are aligned on the same plane (initial state), The opening is shielded from the outside by the main plate portion 42a. Further, the hole 461 that opens from the side surface of the holding portion 43 to the side surface of the protruding portion 41b is also closed by the side plate portion 42b. Therefore, in the state shown in FIG. 22, the opening of the holding portion 43 is completely shielded from the outside.

  In the reaction container 4 having the above-described configuration, if the reaction container 4 is stored in the state shown in FIG. 22 after the reagent is introduced into the holding unit 43, evaporation of the liquid component of the reagent can be prevented. Moreover, if the container part 41 and the cover part 42 are bonded and fixed in the state shown in FIG. 22, leakage of the reaction liquid held by the holding part 43 during subsequent storage or transportation can be prevented. .

  FIG. 23 is a view showing the positional relationship between the container part 41 and the lid part 42 when the sample is discharged to the holding part 43 by the dispensing part 44, and is a side view in the same direction F as in FIG. FIG. 24 is a cross-sectional view taken along the line GG of FIG. These states shown in FIGS. 23 and 24 show a state in which positioning is performed by sliding the lid portion 42 in the positive y-axis direction (rightward in FIG. 23) from the state shown in FIG. In this state, the position of the end portion of the hole portion 461 on the protruding portion 41b side and the position of the end portion of the hole portion 462 on the inner side of the side plate portion 42b overlap, so that the side surface of the holding portion 43 and the outer surface of the side plate portion 42b. The straight air bleed flow channel that reaches is opened.

  For this reason, in the state shown in FIGS. 23 and 24, the sample accurately measured by the measuring unit 442 is held from the discharge unit 443 by applying a pressure significantly higher than the atmospheric pressure to the sample introduced into the measuring unit 442. When discharged to the portion 43, a part of the air inside the holding portion 43 is discharged to the outside through the hole portions 461 and 462.

  When introducing the reagent into the holding portion 43, as shown in the side view of FIG. 25, the lid portion 42 is slid so that the opening portion 45 is positioned above the opening surface of the holding portion 43. Just do it.

  According to the fourth embodiment of the present invention described above, it is possible to provide a reaction vessel suitable for reliably preventing evaporation of the contents with a simple configuration and reducing the size. Further, by providing the dispensing part on the lid part, it is possible to accurately perform the relative positioning with the dispensing part at the time of sample dispensing with a simple configuration. As a result, it is possible to provide a reaction container that can perform highly accurate analysis while reducing the amount of the sample in a low cost.

  Further, according to the fourth embodiment, the hole forming the air vent channel is provided so as to penetrate in the direction perpendicular to the sliding direction of the lid, and the holding part and the outside are provided only during sample dispensing. Since the connection is made, it is possible to further enhance the sealing performance of the holding portion at times other than during dispensing, and reliably prevent leakage of the reaction solution.

(Embodiment 5)
FIG. 26 is a perspective view showing the configuration of the reaction vessel according to Embodiment 5 of the present invention. The reaction container 5 shown in the figure includes a container part 51 that holds a sample and a reagent introduced from the outside, and a lid part 52 that is arranged above the container part 21 and can slide in a predetermined one-dimensional direction. .

  FIG. 27 is a view showing a state in which the reaction vessel 5 is assembled by fitting the container portion 51 and the lid portion 52 in the same manner as in the above-described embodiments, and is a side view in the direction of arrow H in FIG. is there. Hereinafter, the configuration of the container 51 and the lid 52 will be described with reference to FIGS. 26 and 27.

  First, the container part 51 is provided with the flat base part 51a and the protrusion part 51b which protrudes in the direction orthogonal to the bottom face of this base part 51a. The protruding portion 51b is provided with a holding portion 53 having a square opening. The pedestal 51a includes four protrusions 511, 512, 513, and 514 that protrude in the same direction as the protrusion 51b protrudes. The four protruding portions 511 to 514 have the same shape, and the height at which each protruding portion protrudes from the pedestal portion 51a is lower than the height at which the protruding portion 51b protrudes from the pedestal portion 51a. The upper end surface of each projection has an inclined shape that forms an acute angle with the bottom surface of the pedestal 51a.

  Next, the lid portion 52 includes a flat main plate portion 52a and side plate portions 52b and 52c extending in a direction orthogonal to the main plate portion 52a from each of the opposing end portions of the main plate portion 52a. A sample is introduced into the lid 52, and a dispensing part 54 that discharges the introduced sample to the holding part 53 and a cross section that is substantially the same as the opening surface of the holding part 53 and penetrates the main plate part 52 a. An opening 55 is provided. Among these, the dispensing unit 54 includes a liquid holding unit 541, a measuring unit 542, a discharge unit 543, and a flow path 544, similar to the dispensing unit 14 described in the first embodiment.

  The side plate portion 52b has protrusions 521 and 522 that further protrude from an end near the substantially central portion (downward in FIGS. 26 and 27). When the lid 52 slides with respect to the container 51 and reaches a predetermined position in a state where the reaction vessel 5 is assembled, the protrusions 521 and 522 correspond to the protrusions 511 and 512 provided on the container 51 side. A shape (slope shape) that can contact the upper end surface. Similar protrusions 523 and 524 (not shown) are also provided on the side plate portion 52c. The shapes of the protrusions 523 and 524 are the same as the shapes of the protrusions 522 and 521, respectively, due to the symmetry of the lid 52.

  As is clear from FIG. 27, in a state where the reaction vessel 5 is assembled by fitting the container portion 51 and the lid portion 52 (fitted state), the lid portion 52 slides with respect to the container portion 51. The length of the container 51 and the length of the lid 52 in the parallel direction (y-axis direction in FIG. 27) are equal. In the state shown in FIG. 27, that is, in a state where the side surface forming the convex shape of the container portion 51 and the side surface forming the concave shape of the lid portion 52 are aligned on the same plane (initial state), The opening is shielded from the outside by the main plate portion 52a.

  FIG. 28 is a diagram showing the positional relationship between the container 51 and the lid 52 when the reagent is introduced, and is a side view in the direction of arrow H in FIG. In FIG. 28, by sliding the lid 52 in the y-axis negative direction (leftward in FIG. 28) from the state shown in FIG. 27, the inclined surfaces of the protruding portion 512 and the protruding portion 522 facing each other and the protruding portion 513. Further, the opposed slopes (not shown) of the projection 523 come into contact with each other to prevent further sliding of the lid 52. Further, in this case, since the opening 55 comes directly above the holding part 53 with the lid 52 stationary, the reagent can be introduced into the holding part 53 from above the opening 55 without removing the lid 52. .

  FIG. 29 is a diagram showing the positional relationship between the container 51 and the lid 52 when the sample is dispensed by the dispensing unit 54, and is a side view in the direction of arrow H in FIG. 29, by sliding the lid 52 in the positive y-axis direction (rightward in FIG. 29) from the state shown in FIG. 27, the inclined surfaces of the protruding portion 511 and the protruding portion 521 facing each other, and the protruding portion 514 Further, the opposed slopes (not shown) of the protrusion 524 come into contact with each other to prevent the lid 52 from sliding further. In this state, the position of the discharge unit 543 is directly above the opening surface of the holding unit 53.

  As is clear from the above description, the protrusions provided on the container portion 51 and the lid portion 52 respectively constitute at least a part of limiting means for limiting the sliding amount of the lid portion 52 with respect to the container portion 51, and It forms at least a part of positioning means for performing relative positioning between the injection portion 54 and the opening of the holding portion 53.

  According to the fifth embodiment of the present invention described above, evaporation of contents can be reliably prevented with a simple configuration, and a reaction container suitable for miniaturization can be provided. By providing the lid, relative positioning with the dispensing unit during sample dispensing can be performed accurately with a simple configuration. As a result, it is possible to provide a reaction container that can perform highly accurate analysis while reducing the amount of the sample in a low cost.

  Further, according to the fifth embodiment, by providing protrusions on the container part and the lid part, excessive sliding on the container part of the lid part can be prevented, and the state at the time of sample dispensing or reagent introduction can be prevented. Since alignment can be performed easily, it becomes possible to introduce a sample and a reagent more accurately and rapidly.

(Modification of Embodiment 5)
FIG. 30 is a side view showing a configuration of a reaction vessel according to a modification of the fifth embodiment. In the case of the reaction container 5 described above, in the lid portion 52, a protrusion is provided near the center of the side plate portion 52b (and 52c; corresponding to the parentheses in this paragraph) in order to secure the space of the light irradiation region T. It was not possible, and the two protrusions 521 and 522 (and 523 and 524) had to be provided across the central portion. In contrast, in the case of the reaction vessel 501 shown in FIG. 30, the height of the vessel portion 551 is formed higher than the height of the vessel portion 51, and the depth of the holding portion 553 is also formed deeper than the depth of the holding portion 53. In addition, one protrusion 554 having an isosceles trapezoidal side surface shape may be provided near the center of the side surface of the lid portion 552. Therefore, processing of the lid portion 552 is facilitated, and the cost can be further reduced.

  FIG. 31 is a side view showing a configuration of a reaction vessel according to another modification of the fifth embodiment. A reaction vessel 502 shown in the figure has a triangular column shape that protrudes in a direction perpendicular to the sliding direction (left-right direction in the drawing) of the lid portion 562 at the time of assembly in the vicinity of the substantially central portion of the side surface of the protruding portion 561b of the container portion 561. The protrusion 565 is provided. Further, on the side surface of the side plate portion 562b of the lid portion 562, protruding portions 566 and 567 having inclined surfaces that come into contact with the protruding portion 565 are further projected from the side plate portion 562b (downward in FIG. 31). The lid 562 includes a dispensing unit 564 (having a liquid holding unit, a metering unit, a discharge unit, and a flow channel) having the same configuration as the lid unit 52 described above, but has no opening.

  By the way, although not shown, a projection similar to the above-described projection 565 is also provided on the container 561 on the side surface opposite to the projection 561b, while the projection similar to the projections 566 and 567 is provided on the side plate portion. 562c. In the following description, only the protrusions 565, 566, and 567 will be described, but it goes without saying that the same state occurs in the corresponding protrusions on the opposite side (if left and right are reversed).

  FIG. 32 is a diagram showing a positional relationship between the container portion 561 and the lid portion 562 when the reagent is introduced into the reaction container 502. FIG. 32 shows a state in which the slopes of the protrusion 565 and the protrusion 567 are brought into contact with each other by sliding the lid 562 relative to the container 561 in the horizontal right direction in the figure from the state shown in FIG. ing. In this state, the projecting portion 565 and the projecting portion 567 prevent the lid portion 562 from further sliding in the same direction (horizontal right direction) and expose the opening of the holding portion 563.

  FIG. 33 is a diagram showing the positional relationship between the container part 561 and the lid part 562 when a sample is dispensed in the reaction container 502. FIG. 33 shows a state in which the slopes of the protrusion 565 and the protrusion 566 are in contact with each other by sliding the lid 562 relative to the container 561 in the horizontal left direction from the state shown in FIG. ing. In this state, the protruding portion 565 and the protruding portion 566 prevent the lid portion 562 from sliding further in the same direction (horizontal left direction), and the dispensing portion 564 has the measuring portion and the discharging portion of the holding portion 563. It is arranged just above the opening surface.

  Also in the reaction vessel 502 described above, the same effect as the reaction vessel according to the fifth embodiment described above can be obtained. In particular, in the case of this reaction vessel 502, the lid portion 562 does not have an opening, which is suitable for downsizing.

  Note that the shape of the protrusion is not limited to the one described so far. For example, like the reaction vessel 503 shown in FIG. 34, the protrusion 573 that protrudes in a rod shape from the pedestal 571a with respect to the container 571 and In addition to providing 574, protrusions 575 and 576 that protrude in a bar shape with respect to the lid 572 may also be provided (it goes without saying that the same protrusion is also provided on the side plate on the back side of FIG. 34). . In this case, since the contact surfaces of the protrusions are orthogonal to the sliding direction of the lid portion 572 (horizontal direction in FIG. 34), excessive sliding of the lid portion 572 relative to the container portion 571 can be prevented more reliably. It becomes possible.

(Embodiment 6)
FIG. 35 is a perspective view showing a configuration of a reaction vessel according to Embodiment 6 of the present invention. The reaction container 6 shown in the figure includes a container part 61 that holds a sample and a reagent introduced from the outside, and a lid part that is disposed above the container part 61 and is slidable in a predetermined direction with respect to the container part 61. 62.

  The container 61 includes a flat pedestal 61a and a protrusion 61b that protrudes in a column shape from the center of the bottom of the pedestal 61a in a direction perpendicular to the bottom. The protruding portion 61b is formed with a holding portion 63 that holds a sample and a reagent introduced from the outside and reacts the sample and the reagent. The holding portion 63 has a square opening parallel to the upper end surface of the protruding portion 61b, and the inside of the holding portion 63 forms a rectangular parallelepiped space.

  The lid portion 62 has a flat plate-like main plate portion 62a having a square surface, and four side plate portions 62c, 62d, 62e extending from each end of the main plate portion 62a in a direction orthogonal to the main plate portion 62a. , And 62f. Of these, a dispensing portion 64 is provided in the main plate portion 62a. The dispensing unit 64 is formed by connecting four measuring units to the liquid holding unit 641 that holds a sample introduced from the upper surface through different flow paths. More specifically, each of the four measuring units 642a, 642b, 642c, and 642d is connected to the liquid holding unit 641 via the flow paths 644a, 644b, 644c, and 644d. The four measuring units 642a to 642d may include measuring units having different internal volumes, and in the case shown in FIG. 35, the internal volumes of the four measuring units 642a to 642d are all different.

  FIG. 36 is a perspective view when the lid 62 shown in FIG. 35 is viewed upside down (from the −z direction to the + z direction). As shown in FIG. 36, the measuring portions 642a, 642b, 642c, and 642d have discharge portions 643a, 643b, 643c, and 643d that penetrate the surface opposite to where the liquid holding portion 641 is formed, respectively. Is provided.

  In the state where the main plate portion 62a of the lid portion 62 is placed on the container portion 61 and the reaction vessel 6 is assembled, each of the four side surfaces of the pedestal portion 61a in the vertical direction (z-axis direction in FIG. 35) is the lid portion 62. In a state (initial state) aligned with one of the four side surfaces, the opening of the holding portion 63 is shielded from the outside by the main plate portion 62a.

  In the reaction vessel 6 having the above configuration, the lid 62 can be slid in a predetermined two-dimensional direction (on a two-dimensional plane parallel to the xy plane of FIG. 35) with respect to the vessel 61. Since the lid portion 62 has four side plate portions 62b to 62e extending from the respective end portions of the main plate portion 62a, the longitudinal sectional view of an arbitrary cut surface orthogonal to the main plate portion 62a of the lid portion 62 is a concave shape. Make. For this reason, among the surfaces of the main plate portion 62, the surface on which the side plate portions 62b to 62e extend is placed on the upper end surface of the projecting portion 61b, and the main plate portion 62a and the projecting portion 61 of the placed lid portion 62 are placed. If the lid 62 is slid two-dimensionally in contact with the upper end surface, the side plates 62b to 62e function as a stopper that prevents excessive sliding, and the lid 62 is separated from the container 61. There is no. In this sense, the side plate portions 62b to 62e constitute at least a part of a limiting means for limiting the sliding amount of the lid portion 62.

  FIG. 37 is an explanatory diagram showing an outline of positioning of the lid 62 with respect to the container 61 when dispensing a sample. In this figure, the initial state in which the central axes in the vertical direction of the container part 61 and the lid part 62 are aligned is the state (I), and the state in which the sample in the measuring part 642a is discharged to the holding part 63 is the state (II). The outline of the sliding operation with respect to the container portion 61 of the lid portion 62 when transitioning from the state (I) to the state (II) is shown.

  In the case shown in FIG. 37, the lid 62 is moved relative to the container 61 in the two-dimensional horizontal direction, but the final positioning is performed by the apex 62A on the inner surface of the lid 62 (the main plate 62a and the side plate). The boundary point between the portion 62c and the side plate portion 62d) is aligned with one vertex 61A of the upper end surface of the protruding portion 61b. In this sense, the shape of the lid portion 62 may be set so that the discharge portion 643a is directly above the opening surface of the holding portion 63 when the state (II) in which the two vertices 61A and 62A are in contact with each other is reached. Of course, the positions of the other ejection portions 643b, 643c, and 643d are determined in the same manner.

  According to the sixth embodiment of the present invention described above, it is possible to reliably prevent evaporation of the contents with a simple configuration and to provide a reaction vessel suitable for miniaturization. Further, by providing the dispensing part on the lid part, it is possible to accurately perform the relative positioning with the dispensing part at the time of sample dispensing with a simple configuration. As a result, it is possible to provide a reaction container that can perform highly accurate analysis while reducing the amount of the sample in a low cost.

  According to the sixth embodiment, the lid can be slid two-dimensionally with respect to the container, and the positioning of the lid with respect to the container when dispensing the sample is easy. In particular, the opening of the holding part can be closed by the lid part, which is preferable in terms of preventing evaporation of the liquid components of the reagent and the reaction liquid.

  Furthermore, according to the sixth embodiment, it is possible to realize dispensing of various samples by providing the dispensing unit including a plurality of measuring units having different volumes on the lid.

(Modification of Embodiment 6)
FIG. 38 is a perspective view showing the configuration of the lid of the reaction container according to a modification of the sixth embodiment. The lid portion 65 shown in the figure is provided with four dispensing portions 66a, 66b, 66c, and 66d. Each dispensing unit is composed of a set of a liquid holding unit, a metering unit, a discharge unit, and a flow channel, similar to the dispensing unit 14 described in the first embodiment. The volumes of the liquid holding unit and the measuring unit may all be the same, or may be different for each dispensing unit. Note that the perspective view of the lid 65 when viewed upside down is the same as FIG. When the lid portion 65 having the above configuration is used, it is possible to introduce different samples to the four dispensing portions 66a to 66d. Therefore, when the sample is discharged to the holding part 63, the lid 65 may be positioned with respect to the container part 61 as in the above-described sixth embodiment (see FIG. 37).

  FIG. 39 is an explanatory view showing the structure of a reaction vessel according to another modification of the sixth embodiment. A reaction vessel 601 shown in the figure is different from the reaction vessel 6 described above in the shapes of the vessel portion 611 and the lid portion 612. Hereinafter, more specific shapes will be described. As for the container part 611, the base part 611a and the protrusion part 611b make a hexagonal column. The protruding portion 611b is formed with a holding portion 613 that forms a hexagonal columnar space and holds a sample and a reagent, and one of the opposing side surfaces of the holding portion 613 is a side surface of the protruding portion 611b. It is parallel to one of the following. Thereby, any side surface of the holding part 613 can be used as the light irradiation region T.

  The lid portion 612 includes a main plate portion 612a having a regular hexagonal surface, and six side plate portions 612b and 612c extending from each regular hexagonal side of the surface of the main plate portion 612a in a direction orthogonal to the main plate portion 612a. , 612d, 612e, 612f, and 612g. Six dispensing portions 614a, 614b, 614c, 614d, 614e, and 614f are formed on the main plate portion 612a. The configuration of these dispensing units is the same as the configuration of the dispensing unit 14 described in the first embodiment.

  In the reaction vessel 601 having the above-described configuration, the lid 612 is slid two-dimensionally with respect to the vessel 611 so that the apex of the regular hexagon on the upper end surface of the protruding portion 611b and the regular hexagon on the back side of the lid 612 are obtained. By transitioning to a state in which any one of the vertices is in contact with each other, the ejection unit provided in any one dispensing unit is positioned immediately above the opening surface of the holding unit 613. Therefore, after positioning as described above, the sample can be introduced into the holding unit 613 by applying a pressure significantly higher than the atmospheric pressure to the sample introduced into the corresponding dispensing unit. In this sense, if different types of samples are introduced into the six dispensing units 614 a to 614 f, various samples can be introduced into the holding unit 613.

  FIG. 40 is an explanatory diagram showing a configuration of a reaction vessel according to still another modification of the sixth embodiment. A reaction container 602 shown in the figure includes a container part 621 and a lid part 622. The container portion 621 includes a triangular column-shaped pedestal portion 621a and a protruding portion 621b that protrudes upward from the pedestal portion 621a in a columnar shape. The protruding portion 621b is formed with a rectangular parallelepiped holding portion 623 having an upper end surface as an opening. The outer shape of the protruding portion 621b has a shape in which a part of a triangular prism whose bottom surface is a regular triangle is cut out. The cutout portion is parallel to one side surface of the protruding portion 621b and parallel to one set of opposing side surfaces of the holding portion 623. As a result, the side surface of the cutout portion can be used as the light irradiation region T.

  The lid portion 622 includes a main plate portion 622a having a regular triangular surface, and three side plate portions 622b and 622c extending from each regular triangle side of the surface of the main plate portion 622a in a direction perpendicular to the main plate portion 622a. , And 622d. Three dispensing portions 624a, 624b, and 624c are formed on the main plate portion 622a. The configuration of these dispensing units is the same as the configuration of the dispensing unit 14 described in the first embodiment.

  Even in the reaction container 602 having the above-described configuration, when dispensing a sample, the lid 622 is slid in a predetermined two-dimensional direction, so that any one of the apexes of the regular triangle on the upper end surface of the protruding portion 621b. The lid 622 is positioned with respect to the container 621 by aligning it with one of the apexes of the regular triangle on the back side of the lid 612. And as a result of this positioning, since the discharge part provided in any of the dispensing parts is located immediately above the opening surface of the holding part 623, by applying a pressure significantly larger than the atmospheric pressure to the corresponding dispensing part, The sample introduced into the dispensing unit can be discharged to the holding unit 623. Accordingly, in this case as well, the same effect as in the case of the reaction vessel 601 described above can be obtained.

  By the way, more generally, a container portion provided with a protruding portion that protrudes in an n-gonal prism shape (n is an integer of 3 or more) in a direction orthogonal to the pedestal portion, and a lid portion having an n-shaped main plate portion (n sets of dispensing) A reaction vessel can be formed by combining the above. In this sense, the reaction vessel can also be formed by a combination of a protruding portion that protrudes in a columnar shape where n is an infinite limit and a lid portion having a circular main plate portion. However, depending on the shape of the protruding portion, it is necessary to cut out a part of the container portion in order to provide the light irradiation region T as in the case of the protruding portion 621b of the reaction vessel 602 described above. Note that the surface of the lid portion may be m-gonal (an integer of 3 or more such that m ≠ n). The shape of the pedestal portion is arbitrary regardless of the shape of the protruding portion.

(Embodiment 7)
FIG. 41 is a perspective view showing the configuration of the reaction container according to Embodiment 7 of the present invention. The reaction container 7 shown in the figure includes a container part 71 that holds a sample and a reagent introduced from the outside, and a lid part 72 that is disposed above the container part 71 and can slide in a predetermined one-dimensional direction. .

  The container portion 71 includes a flat pedestal portion 71a and a protruding portion 71b that protrudes in a direction orthogonal to the bottom surface of the pedestal portion 71a. In this protrusion 71b, three holding parts 73a, 73b, and 73c for holding a sample or reagent containing a liquid and reacting the sample and the reagent are arranged in the longitudinal direction of the protrusion 71b (the y-axis direction in FIG. 41). ) At regular intervals. Each holding part has a square-shaped opening parallel to the upper end surface of the protruding part 71b, and the inside forms a rectangular parallelepiped space. For convenience of the following description, it is assumed that the holding portions 73a to 73c have the same shape. In this case, the container part 71 is essentially the same as what connected the three container parts 21 of the reaction container 2 which concerns on the said Embodiment 2. FIG.

  The lid portion 72 includes a flat main plate portion 72a and side plate portions 72b and 72c extending from the opposing ends of the main plate portion 72a in a direction orthogonal to the main plate portion 72a. One side surface (side surface parallel to the xz plane in FIG. 41) of the lid portion 72 has a concave shape that can be fitted to the side surface forming the convex shape of the container portion 21. Moreover, the cover part 72 has a uniform external shape along the direction (y-axis direction of FIG. 41) orthogonal to the side surface which makes the concave shape.

  The lid 72 has a cross section of the same shape as the three dispensing portions 74a, 74b, and 74c for introducing the sample and discharging the introduced sample, and the opening surfaces of the holding portions 73a to 73c. The three openings 75a, 75b, and 75c that pass through are alternately provided along the longitudinal direction of the main plate portion 72a (y-axis direction in FIG. 41). Among these, the dispensing parts 74a to 74c each have a liquid holding part, a metering part, a discharge part, and a flow path, similarly to the dispensing part 14 described in the first embodiment. The lid portion 72 having such a configuration is essentially the same as that obtained by connecting three lid portions 22 of the reaction container 2 according to the second embodiment.

  42 is a view showing a state in which the reaction vessel 7 is assembled by fitting the container portion 71 and the lid portion 72 having the above configuration, and is a vertical cross-sectional view taken along the line II of FIG. As is clear from FIG. 42, the direction in which the lid 72 slides with respect to the container 71 in a state in which the container 71 and the lid 72 are fitted and the reaction vessel 7 is assembled (fitted state). The length of the container portion 71 and the length of the lid portion 72 in the direction parallel to (the y-axis direction in FIG. 42) are equal. In the state shown in FIG. 42, that is, the side surface forming the convex shape of the container portion 71 and the side surface forming the concave shape of the lid portion 72 are aligned on the same plane (set as the initial state). The openings 73c are shielded from the outside by the main plate portion 72a.

  FIG. 43 is a diagram showing the positional relationship between the container part 71 and the lid part 72 when the reagent is introduced into each holding part, and the lid in the y-axis negative direction (left side in FIG. 43) from the state shown in FIG. It is sectional drawing which shows the state which performed the positioning by sliding the part 72. FIG. Further, FIG. 44 is a diagram showing the positional relationship between the container part 71 and the lid part 72 when dispensing a sample to each holding part. From the state shown in FIG. 42, the y-axis positive direction (rightward in FIG. 43) is shown. FIG. 6 is a cross-sectional view showing a state where the lid portion 72 is slid and positioned.

  The reaction container 7 according to the seventh embodiment corresponds to the connection of three reaction containers 2 according to the second embodiment, and therefore the state shown in FIG. 42 is essentially the same as the state shown in FIG. It is. 43 and 44 are essentially the same as the states shown in FIGS. 10 and 11, respectively. Therefore, the introduction of the reagent in the state shown in FIG. 43 can be performed in the same manner as the introduction of the reagent in the state shown in FIG. 10, and the dispensing of the sample in the state shown in FIG. The sample can be carried out in the same manner as the sample dispensing.

  In the above description, the number of holding parts formed in the container part 71 and the number of dispensing parts and openings provided in the lid part 72 are all three, but this is only an example, The number is arbitrary and may be different from each other. For example, the dispensing part provided in the lid part may be one. In this way, when there is one dispensing unit, liquid is introduced into the liquid holding unit in the dispensing unit once in advance, and thereafter each holding is performed by sliding the lid and applying pressure to the top of the lid. It is only necessary to dispense the sample to the part, and it is possible to realize efficient dispensing of the sample.

  In addition, the volumes of the plurality of holding units formed in the container unit 71 may be different, or the volumes of the liquid holding unit and the measuring unit among the plurality of dispensing units formed in the lid unit may be different. Good. For example, by changing the volume of each measuring unit, it is possible to discharge samples having different volumes to each holding unit or to discharge different types of samples to each holding unit.

  According to the seventh embodiment of the present invention described above, it is possible to reliably prevent evaporation of the contents with a simple configuration and to provide a reaction vessel suitable for miniaturization. Further, by providing the dispensing part on the lid part, it is possible to accurately perform the relative positioning with the dispensing part at the time of sample dispensing with a simple configuration. As a result, it is possible to provide a reaction container that can perform highly accurate analysis while reducing the amount of the sample in a low cost.

  Further, according to the seventh embodiment, since the container portion or the plurality of holding portions are provided, and the lid portion is provided with a plurality of dispensing portions, it is possible to efficiently dispense various samples and introduce reagents. It becomes possible to carry out.

(Embodiment 8)
FIG. 45 is a perspective view showing a configuration of a reaction vessel according to Embodiment 8 of the present invention. A reaction container 8 shown in the figure includes a container part 81 for holding a sample and a reagent introduced from the outside, and a lid part 82 disposed above the container part 81 and slidable in a predetermined one-dimensional direction. The container portion 81 and the lid portion 82 are connected by four connecting members 86.

  The container part 81 includes a flat pedestal part 81a and a protruding part 81b protruding in a direction orthogonal to the pedestal part 81a. Four insertion holes 811a, 811b, 811c, and 811d through which the connecting member 86 is inserted are formed in the four rectangular corners forming the bottom surface of the pedestal portion 81a in a direction perpendicular to the bottom surface. One side surface (side surface parallel to the xz plane in FIG. 45) of the container portion 81 has a convex shape, and is one along the direction (y-axis direction in FIG. 45) perpendicular to the side surface forming the convex shape. It has various external shapes. A holding portion 83 that holds a sample and a reagent and reacts the sample and the reagent is formed at a substantially central portion of the protruding portion 81b. The holding portion 83 has a square opening parallel to the upper end surface of the protruding portion 81b, and the inside of the holding portion 83 forms a rectangular parallelepiped space.

  The lid portion 82 includes a flat main plate portion 82a and side plate portions 82b and 82c extending from the opposing ends of the main plate portion 82a in a direction perpendicular to the main plate portion 82a. Four insertion holes 821a, 821b, 821c, and 821d are formed in the four corners of the main plate portion 82a in a direction orthogonal to the main plate portion 82a in order to insert the connecting member 86. One side surface (side surface parallel to the xz plane in FIG. 45) of the lid portion 82 has a concave shape that can be fitted to the side surface forming the convex shape of the container portion 81. Moreover, the cover part 82 has a uniform external shape along the direction (y-axis direction of FIG. 45) orthogonal to the side surface which makes the concave shape.

  When assembling the reaction vessel 8 by fitting the container portion 81 and the lid portion 82 described above, the corresponding insertion holes 811a to 811d of the container portion 81 and the insertion hole portions 821a to 821d of the lid portion 82 are inserted. The positions of the through holes (here, the through holes having the same alphabet at the end of the code correspond to each other) are aligned in the vertical direction, and they are connected and fixed by one connecting member 86. Thereby, the reaction vessel 8 in which the vessel portion 81 and the lid portion 82 are firmly connected is formed. The number of connecting members 86 may be other than four. For example, as long as it is fixed on both sides of the protruding portion 81b, at least two connecting members 86 may be provided. Thus, the number of the connecting members 86 is appropriately determined according to the size of the reaction vessel 8 and the application.

  In the reaction vessel 8 having the above configuration, a predetermined amount of reagent can be introduced into the holding portion 83 before the container portion 81 and the lid portion 82 are connected and fixed via the connecting member 86. In this case, the container 81 and the lid 82 are connected and fixed after the introduction of the reagent, so that the reaction container 8 can be stored or transported while the state in which the opening of the holder 83 is shielded from the outside is reliably maintained. it can. Therefore, it is possible to reliably prevent the liquid component of the introduced reagent from evaporating or leaking out.

  When the sample is dispensed by the dispensing unit 84 after the reagent has been introduced, the connecting member 86 is first cut, and the lid 82 is predetermined with respect to the container unit 81 as in the above-described embodiments. It is necessary to be able to slide in a one-dimensional direction (y-axis direction in FIG. 45). FIG. 46 is an explanatory diagram showing an outline when the connecting member 86 is cut by a predetermined cutting device. The cutting device 801 shown in FIG. 46 includes a guide passage 802 that guides the reaction vessel 8 automatically or manually, and a cutting portion 803 that is provided in the middle of the guide passage 802 and cuts the connecting member 86.

  The connection member 86 is cut using the cutting device 801 as follows. When the reaction vessel 8 introduced into the guide passage 802 advances in the guide passage 802 in a predetermined direction (horizontal right in FIG. 46), it proceeds first when the cutting portion 803 passes through the connecting member 86. The connecting member 86 located on the front side (right side in FIG. 46) with respect to the direction is cut first. Thereafter, when the reaction vessel 8 further advances through the guide passage 802, the connecting member 86 located on the rear side (left side in FIG. 46) with respect to the traveling direction is cut. Therefore, FIG. 46 shows a state after the cutting of all the connecting members 86 is completed. The connecting member 86 can be formed using a resin, for example. In this case, what can melt | dissolve or cut | disconnect resin, such as a soldering iron and a cutter, should just be applied as the cutting part 803. FIG.

  Since the reaction vessel 8 from which all the connecting members 86 have been cut allows the lid portion 82 to slide in a predetermined one-dimensional direction with respect to the vessel portion 81, the sample is then transferred to the dispensing portion 84 (the liquid holding portion thereof). By introducing and sliding the lid part 82 as appropriate, positioning is performed so that the discharge part of the dispensing part 84 comes directly above the holding part 83. Thereafter, a predetermined amount of the sample is discharged to the holding unit 83 by applying a pressure significantly higher than the atmospheric pressure to the sample introduced into the dispensing unit 84.

  According to the eighth embodiment of the present invention described above, it is possible to reliably prevent evaporation of the contents with a simple configuration and to provide a reaction vessel suitable for miniaturization. Further, by providing the dispensing part on the lid part, it is possible to accurately perform the relative positioning with the dispensing part at the time of sample dispensing with a simple configuration. As a result, it is possible to provide a reaction container that can perform highly accurate analysis while reducing the amount of the sample in a low cost.

  Further, according to the eighth embodiment, the container part and the lid part can be connected and fixed until the reaction container is used, and the reagent in the holding part can be sealed, so that the reagent is stored or transported while being held. It becomes possible.

  Note that the connecting member is not necessarily made of resin. For example, the container portion and the lid portion may be connected using a piano wire, a thread, or the like, or both may be connected using an appropriate adhesive tape. In these cases, the cutting unit 803 may be realized by a cutter such as a cutter.

  By the way, the function of the above-described cutting device 801 may be provided in an analyzer for analyzing a sample sample using a reaction container. Thereby, a series of processes from the cutting of the connecting member to the analysis of the specimen sample can be performed smoothly and quickly.

(Embodiment 9)
FIG. 47 is a perspective view showing the configuration of the reaction container according to Embodiment 9 of the present invention. The reaction container 9 shown in the figure includes a container part 91 that holds a sample and a reagent introduced from the outside, a lid part 92 that is arranged above the container part 91 and that can slide in a predetermined one-dimensional direction, and a container. And a hollow cartridge 93 that can store four sets of the portion 91 and the lid portion 92.

  FIG. 48 is a diagram illustrating the configuration of the container portion 91 and the lid portion 92. The container 91 shown in the figure includes a flat pedestal 91a and a protrusion 91b that protrudes in a direction perpendicular to the bottom surface of the pedestal 91a. The protruding portion 91b is provided with three holding portions 94 having the same shape. On the other hand, the lid portion 92 includes a flat plate-like main plate portion 92a and side plate portions 92b and 92c extending from the opposing ends of the main plate portion 92a in a direction orthogonal to the main plate portion 92a. The main plate portion 92a is provided with three measuring portions 95 having the same shape, and a discharge portion 96 penetrating the surface of the opposite main plate portion 92a is formed in the bottom surface of each measuring portion 95.

  In a state where the container portion 91 and the lid portion 92 are fitted (fitted state), the length of the container portion 91 and the length of the lid portion 92 in a direction parallel to the direction in which the lid portion 92 slides with respect to the container portion 91. Are equal. Further, in the state in which the convex side surface of the container portion 91 and the concave side surface of the lid portion 92 are aligned on the same plane (a state in which the container portion 91 is accommodated in the cartridge 93), the opening of each holding portion 94 is the main plate. The portion 92a is shielded from the outside.

  49 is a cross-sectional view taken along the line JJ of FIG. 47 and is a vertical cross-sectional view of the reaction vessel 9. As shown in FIG. 49, the cartridge 93 is provided with a hollow cylindrical liquid holding portion 97 for holding a liquid. The liquid holding portions 97 are provided in the same number as the total number of the measuring portions 95 on each lid portion 92 when the cartridge 93 includes a set of the container portion 91 and the lid portion 92 as much as possible (see FIG. 47). 12 when shown). Each liquid holding portion 97 is formed so as to be positioned directly above one of the measuring portions 95 formed on the lid portion 92 when the container portion 91 and the lid portion 92 are fitted and stored in the cartridge 93. The diameter of each liquid holding part 97 is larger than the diameter of the measuring part 95 located immediately below. A channel having a diameter smaller than the diameter of the measuring unit 95 is formed below the liquid holding unit 97, and the sample may be introduced from the liquid holding unit 97 to the measuring unit 95 via the channel. Good.

  By the way, it is preferable that the holding part 94 formed in the container part 91 is not located under the discharge part 96 in the state accommodated in the cartridge 93 (refer FIG. 49). This is to prevent evaporation and denaturation of the reagent in the holding portion 94 in a state where the reagent is introduced into the container portion 91 before the container portion 91 and the lid portion 92 are accommodated in the cartridge 93. Because it can.

  In the reaction container 9 having the above-described configuration, when the sample introduced into the measuring unit 95 is discharged and dispensed, the container 91 and the lid 92 are taken out from the cartridge 93, and the discharge unit 96 is connected to the holding unit 94. By positioning the lid portion 92 with respect to the container portion 91 so as to be positioned immediately above the opening surface, the lid portion 92 is positioned with respect to the container portion 91. Thereafter, as described in each of the above-described embodiments, the sample measured accurately by the measuring unit 95 is discharged from the discharge unit 96 by applying a pressure significantly larger than the atmospheric pressure.

  Note that the surfaces of the container 91 and the lid 92 may be made hydrophobic. By doing so, even if a sample that is not introduced into the weighing unit 95 leaks out when they are taken out from the cartridge 93, the sample does not penetrate into the container 91 or the lid 92 due to hydrophobicity. More preferred.

  According to the ninth embodiment of the present invention described above, it is possible to reliably prevent evaporation of the contents with a simple configuration, and to provide a reaction vessel suitable for miniaturization. Further, by providing the dispensing part on the lid part, it is possible to accurately perform the relative positioning with the dispensing part at the time of sample dispensing with a simple configuration. As a result, it is possible to provide a reaction container that can perform highly accurate analysis while reducing the amount of the sample in a low cost.

  Further, according to the ninth embodiment, by storing a plurality of sets of container portions and lid portions in one cartridge, it becomes possible to introduce samples into the weighing unit provided on the lid portion all at once. . For this reason, the labor for introducing the sample can be reduced, and the sample can be introduced more quickly.

  Furthermore, according to the ninth embodiment, when the container and the lid are stored in the cartridge after the reagent is introduced in advance into the holder provided in the container, the opening surface of the holder is closed with the lid. Furthermore, since the container portion and the lid portion are held by the cartridge, the holding portion can be shielded from the outside, and the evaporation and leakage of the reagent in the holding portion can be reliably prevented.

  Further, according to the ninth embodiment, particularly when the container portion and the lid portion are miniaturized, handling them at the time of dispensing is further facilitated by storing them together in a cartridge.

  Note that the number of containers and lids that can be stored in one cartridge is not limited to that described above. In addition, a container having a size other than the set of the container 91 and the lid 92 described above can be applied to the container and the lid stored in the cartridge. For example, the reaction container 2 according to the second embodiment (see FIG. 8) and the reaction container 7 according to the seventh embodiment (see FIG. 41) may be appropriately combined and stored in the cartridge 93 without excess or deficiency. The effect obtained is the same.

(Modification of Embodiment 9)
FIG. 50 is a perspective view showing a configuration of a reaction vessel according to a modification of the ninth embodiment. A reaction vessel 901 shown in the figure includes a cartridge 98 different from the reaction vessel 9 described above. The cartridge 98 is provided with a square-shaped opening 99 on the upper surface portion, and this functions as a liquid holding portion. Therefore, when the sample is introduced, the sample can be collectively introduced into each measuring portion 95 formed on the upper surface of the lid portion 92 by introducing the sample into the opening 99.

  When dispensing the sample introduced into the measuring unit 95 to each holding unit 94, the container unit 91 and the lid unit 92 are taken out from the cartridge 98, and the discharge unit 96 is positioned immediately above the opening surface of the holding unit 94. After positioning the lid 92 by sliding the lid 92 with respect to the container 91, the sample is discharged by applying a pressure significantly higher than the atmospheric pressure to the sample accurately weighed by the measuring unit 95.

  According to a modification of the ninth embodiment, since the introduction of the sample into each measuring unit is much easier, it is suitable for the case where the same sample is introduced all at once into all the holding units in the cartridge. is there.

(Embodiment 10)
FIG. 51 is a perspective view showing the configuration of the reaction container according to Embodiment 10 of the present invention. A reaction container 10 shown in the figure includes a container part 101 that holds a sample and a reagent introduced from the outside, and a lid part 102 that is arranged above the container part 101 and can slide in a predetermined one-dimensional direction. .

  The container part 101 is provided with the flat base part 101a and the protrusion part 101b which protrudes in the direction orthogonal to the bottom face of this base part 101a. One side surface (side surface parallel to the xz plane in FIG. 51) of the container portion 101 has a convex shape, and is along a direction (y-axis direction in FIG. 51) orthogonal to the side surface forming the convex shape. Has a uniform outer shape. The protruding portion 101b is formed with a holding portion 103 that holds a sample or reagent containing a liquid and reacts the sample and the reagent, and a dispensing portion 104 that introduces the sample into the holding portion 103. Yes. Among these, the holding | maintenance part 103 has a square-shaped opening parallel to the upper end surface of the protrusion part 101b, and the inside of the holding | maintenance part 103 makes a rectangular parallelepiped space.

  52 is a diagram showing an internal configuration of the container portion 21, and is a vertical sectional view taken along the line KK of FIG. As shown in FIG. 51, the dispensing unit 104 is formed by cutting or the like from the upper end surface of the protruding portion 101b, and includes a liquid holding unit 1041 that holds a small amount of sample containing liquid, a weighing unit 1042 that measures the sample, A discharge portion 1043 that penetrates from the lower side of the measuring unit 1042 to the side surface of the holding unit 103, and a flow path 1044 that connects the liquid holding unit 1041 and the measuring unit 1042. Since the discharge unit 1043 is smaller in diameter than the measuring unit 1042, the flow path resistance is large, and the sample is not discharged from the discharge unit 1043 even when a pressure of about normal atmospheric pressure is applied to the sample.

  When dispensing the reagent into the reaction container 10 having the above-described configuration, the opening of the holding part 103 is exposed to the outside by sliding the lid part 102 with respect to the container part 101, and the reagent is released from the exposed opening surface. Is introduced. In this case, for example, the lid 102 may be stopped at a position indicated by reference numeral 102-1 in FIG. Thereafter, for example, the lid 22 is slid to a position indicated by reference numeral 102-2 in FIG. This makes it possible to prevent evaporation of the liquid component of the reagent.

  Thereafter, the lid portion 102 is further slid as necessary (not necessary when the lid portion 102 is stationary at the position indicated by reference numeral 102-2 in FIG. 52), thereby exposing the dispensing portion 104 to hold the liquid. A sample is introduced into the unit 1041. The sample introduced into the liquid holding unit 1041 is introduced from the channel 1044 to the measuring unit 1042 by capillary force. Thereafter, by applying a pressure significantly higher than the atmospheric pressure to the sample introduced into the measuring unit 1042, the sample accurately measured by the measuring unit 1042 is discharged from the discharge unit 1043 to the holding unit 103.

  According to the tenth embodiment of the present invention described above, it is possible to provide a reaction vessel suitable for reliably preventing evaporation of the contents with a simple configuration and reducing the size. As a result, it is possible to provide a reaction container that can perform highly accurate analysis while reducing the amount of the sample in a low cost.

  Further, according to the tenth embodiment, since the dispensing part is provided on the container part side, the sample can be introduced without positioning the lid part. Further, the opening of the holding portion can be completely shielded from the outside by the lid portion, and it is possible to reliably prevent evaporation of the liquid component due to drying.

  51 and 52, the length of the lid 102 in the direction parallel to the sliding direction with respect to the container 101 (the y direction in FIG. 51) in the assembled state of the reaction container 10 is the same in the container 101 in the same state. Although the case where it is shorter than the length of the same direction is shown, both lengths may be the same.

(Modification of Embodiment 10)
FIG. 53 is a view showing the structure of the container portion of the reaction container according to a modification of the tenth embodiment, and is a longitudinal sectional view when seen on the same cut surface as FIG. The container unit 151 shown in FIG. 53 includes a liquid holding unit 152, a measuring unit 153, an introduction unit 154, a discharge unit 155, a holding unit 156, and an excess flow channel 157, and has substantially the same outer shape as the container unit 101. Note that the lid 102 is applied as the lid.

  The liquid holding portion 152 is formed as a bottomed recess having an opening upward with respect to the main body portion of the container portion 151, and the horizontal cross-sectional area decreases as it goes downward in the vertical direction. A partition wall 158 is provided between the liquid holding unit 152 and the holding unit 156. The introduction unit 154 connects the liquid holding unit 152 and the measuring unit 153 to form a flow path for introducing the sample held in the liquid holding unit 152 into the measuring unit 153. The discharge unit 155 connects the measuring unit 153 and the holding unit 156, and discharges the liquid measured by the measuring unit 153 to the holding unit 156.

  The surplus channel 157 is a channel through which surplus liquid that has not been introduced into the measuring unit 153 flows, and one end thereof is connected to the liquid holding unit 152 and the introduction unit 154. The other end portion of the surplus channel 157 is formed to be connected to the upper end surface of the container portion 151 and open to the outside.

  In the container unit 151 having the above configuration, when a sample is introduced into the liquid holding unit 152, the introduced sample is introduced from the introduction unit 154 to the measuring unit 153 by capillary force. Thereafter, by applying a predetermined pressure P1 to the sample from above the liquid holding unit 152, the liquid not introduced into the measuring unit 153 is caused to flow into the surplus flow path 157 and separated from the liquid introduced into the measuring unit 153. . The pressure P1 at this time is higher than the pressure at which the liquid not introduced into the measuring unit 153 starts to flow, and is lower than the pressure at which the liquid introduced into the measuring unit 153 starts to flow. .

  Thereafter, the metering unit 153 is filled by applying from the top of the liquid holding unit 152 a pressure P2 higher than the pressure P1 described above and higher than the pressure at which the liquid introduced into the metering unit 153 starts to flow. The amount of the sample is discharged from the discharge unit 155 to the holding unit 156. Note that the sliding operation and the stationary position of the lid 22 at the time of reagent introduction and sample dispensing are the same as those in the tenth embodiment.

  Needless to say, according to the reaction container according to the modified example of the tenth embodiment described above, the same effects as those of the tenth embodiment can be obtained.

(Other embodiments)
So far, the first to tenth embodiments have been described in detail as the best mode for carrying out the present invention, but the present invention should not be limited only by those embodiments. For example, it is needless to say that embodiments realized by appropriately combining the above-described embodiments are also included. Thus, the present invention can include various embodiments and the like not described herein, and various design changes and the like can be made without departing from the technical idea specified by the claims. It is possible to apply.

It is a perspective view which shows the structure of the reaction container which concerns on Embodiment 1 of this invention. It is the sectional view on the AA line of FIG. It is a perspective view which shows the state which assembled the reaction container which concerns on Embodiment 1 of this invention. It is a side view of the arrow B direction of FIG. It is explanatory drawing which shows the state which slid the cover part from the state of FIG. 4, and shielded the opening of the holding | maintenance part from the outside. It is a figure which shows the structure of the reaction container which concerns on the modification of Embodiment 1 of this invention. It is a figure which shows the structure of the reaction container which concerns on another modification of Embodiment 1 of this invention. It is a perspective view which shows the structure of the reaction container which concerns on Embodiment 2 of this invention. It is the DD sectional view taken on the line of FIG. 8 (at the time of an assembly). It is explanatory drawing which shows the positional relationship of the container part at the time of reagent introduction | transduction in the reaction container which concerns on Embodiment 2 of this invention, and a cover part. It is a figure which shows the positional relationship of the container part at the time of sample dispensing in the reaction container which concerns on Embodiment 2 of this invention, and a cover part. It is sectional drawing which shows the structure of the reaction container which concerns on the modification of Embodiment 2 of this invention. It is sectional drawing which shows the structure of the reaction container which concerns on another modification of Embodiment 2 of this invention. It is sectional drawing which shows the structure of the reaction container which concerns on another modification of Embodiment 2 of this invention. In the reaction container of FIG. 14, it is a figure which shows the state which seals a holding | maintenance part using a liquid. In the reaction container of FIG. 14, it is a figure which shows the state which affixes a sheet | seat and seals a holding | maintenance part. It is a perspective view which shows the structure of the reaction container which concerns on Embodiment 3 of this invention. It is a top view which shows the structure of the cover part of the reaction container which concerns on the modification of Embodiment 3 of this invention. It is a side view of the arrow E direction of FIG. It is a top view which shows the structure of the cover part of the reaction container which concerns on another modification of Embodiment 3 of this invention. It is a perspective view which shows the structure of the reaction container which concerns on Embodiment 4 of this invention. It is a side view (at the time of an assembly) of the arrow F direction of FIG. It is a figure which shows the positional relationship of the container part at the time of sample dispensing in the reaction container which concerns on Embodiment 4 of this invention, and a cover part. It is the GG sectional view taken on the line of FIG. It is a figure which shows the positional relationship of the container part at the time of reagent introduction | transduction in the reaction container which concerns on Embodiment 4 of this invention, and a cover part. It is a perspective view which shows the structure of the reaction container which concerns on Embodiment 5 of this invention. It is a side view (at the time of an assembly) of the arrow H direction of FIG. It is explanatory drawing which shows the positional relationship of the container part at the time of reagent introduction | transduction in the reaction container which concerns on Embodiment 5 of this invention, and a cover part. It is a figure which shows the positional relationship of the container part at the time of sample dispensing in the reaction container which concerns on Embodiment 5 of this invention, and a cover part. It is a side view which shows the structure of the reaction container which concerns on the modification of Embodiment 5 of this invention. It is a side view which shows the structure of the reaction container which concerns on another modification of Embodiment 5 of this invention. It is a figure which shows the positional relationship of the container part at the time of reagent introduction | transduction in the reaction container which concerns on another modification of Embodiment 5 of this invention, and a cover part. It is a figure which shows the positional relationship of the container part at the time of sample dispensing in the reaction container which concerns on another modification of Embodiment 5 of this invention, and a cover part. It is a side view which shows the structure of the reaction container which concerns on another modification of Embodiment 5 of this invention. It is a perspective view which shows the structure of the reaction container which concerns on Embodiment 6 of this invention. FIG. 36 is a perspective view when the lid shown in FIG. 35 is viewed upside down. In the reaction container which concerns on Embodiment 6 of this invention, it is explanatory drawing which shows the outline | summary of positioning of the cover part at the time of dispensing of a sample. It is a perspective view which shows the structure of the cover part of the reaction container which concerns on the modification of Embodiment 6 of this invention. It is explanatory drawing which shows the structure of the reaction container which concerns on another modification of Embodiment 6 of this invention. It is explanatory drawing which shows the structure of the reaction container which concerns on another modification of Embodiment 6 of this invention. It is a perspective view which shows the structure of the reaction container which concerns on Embodiment 7 of this invention. It is the II sectional view taken on the line of FIG. 41 (at the time of an assembly). It is a figure which shows the positional relationship of the container part at the time of reagent introduction | transduction in the reaction container which concerns on Embodiment 7 of this invention, and a cover part. It is a figure which shows the positional relationship of the container part at the time of sample dispensing in the reaction container which concerns on Embodiment 7 of this invention, and a cover part. It is a perspective view which shows the structure of the reaction container which concerns on Embodiment 8 of this invention. It is explanatory drawing which shows the example of 1 cutting of the connection member using a cutting device. It is a perspective view which shows the structure of the reaction container which concerns on Embodiment 9 of this invention. It is a perspective view which shows the structure of the container part and cover part of the reaction container which concern on Embodiment 9 of this invention. It is the JJ sectional view taken on the line of FIG. It is a perspective view which shows the structure of the reaction container which concerns on the modification of Embodiment 9 of this invention. It is a perspective view which shows the structure of the reaction container which concerns on Embodiment 10 of this invention. It is the KK sectional view taken on the line of FIG. It is sectional drawing which shows the structure of the container part of the reaction container which concerns on the modification of Embodiment 10 of this invention.

Explanation of symbols

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 110, 120, 201, 202, 203, 501, 502, 503, 601, 602, 901 Reaction vessel 11, 21, 31, 41 51, 61, 71, 81, 91, 101, 111, 121, 151, 213, 551, 561, 571, 611, 621 Container part 12, 22, 32, 42, 47, 52, 62, 65, 72, 82, 92, 102, 112, 122, 221, 222, 223, 552, 562, 572, 612, 622 Lid 13, 23, 33, 43, 53, 63, 73a-73c, 83, 94, 103, 113 123, 156, 233, 553, 563, 613, 623 Holding part 14, 24, 34, 44, 54, 64, 66a to 66d, 74a to 74c, 84, 104, 114, 24, 564, 614a to 614f, 624a to 624c Dispensing part 35, 45, 55, 65, 75a to 75c, 85, 97, 99 Opening part 36, 126, 361, 362 Groove part 86 Connecting member 93, 98 Cartridge 95, 142, 153, 242, 342, 442, 542, 642a to 642d, 1042 Weighing part 96, 143, 155, 243, 343, 443, 543, 643a to 643d, 1043 Discharge part 125 Guide part 141, 152, 241, 341 , 441, 541, 641, 1041 Liquid holding part 144, 244, 344, 444, 544, 644 a to 644 d, 1044 Flow path 154 Introduction part 157 Surplus flow path 461, 462 Hole part 511 to 514, 521 to 524, 554, 565-567, 573-576 Protrusion 80 Cutting device 802 the guiding passage 803 cuts 811A～811d, holes L for liquids 821a~821d through S sheet T light irradiation area

Claims (10)

A reaction vessel that is applied to an analyzer that analyzes a sample containing a liquid and that reacts the sample with a predetermined reagent,
A container for holding a sample and a reagent introduced from the outside through a predetermined opening;
A lid portion that is combined with the container portion and is slidable in a predetermined direction including at least an opening surface of the opening relative to the container portion;
A reaction vessel comprising: The container part is
The reaction container according to claim 1, further comprising a light irradiation region for irradiating light in order to analyze a sample, a reagent, or a reaction solution of the sample and the reagent held in the container part.   The reaction container according to claim 1, wherein the state reached by sliding the lid with respect to the container includes a state in which the lid shields the opening from the outside.   The reaction container according to claim 1, wherein the state reached by sliding the lid with respect to the container includes a state in which the opening is exposed to the outside.   The reaction container according to claim 1, further comprising guiding means for guiding a slide of the lid part with respect to the container part.   The reaction container according to claim 1, further comprising limiting means for limiting a sliding amount of the lid part with respect to the container part.   The reaction container according to claim 1, further comprising a dispensing unit that measures the sample to a predetermined volume and introduces the measured sample into the container unit. The dispensing part is
A weighing unit for introducing the sample and weighing it to a predetermined volume;
A discharge unit for discharging the sample measured by the measurement unit to the outside;
Have
The reaction container according to claim 7, wherein a predetermined pressure is applied to the sample introduced into the measuring unit to discharge the sample into the container unit.   The reaction container according to claim 7, wherein the dispensing unit is provided on the lid.   The reaction container according to claim 7, wherein the dispensing unit is provided in the container unit.

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