JP2006263375A - Container with double chambers for medical use - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medical container with double chambers with which the administration of a medical agent without being mixed is prevented. <P>SOLUTION: The medical container 1 with double chambers comprises: a soft bag 2 divided into a first medical agent chamber 3 and a second medical agent chamber 4 with the use of a weak sealing part 13 for partitioning; a discharge port 7 attached to the first medical agent chamber 3: the first and second medical agents 5, 6; a medical agent container 10 attached to the first medical agent chamber 3; a third medical agent 12; and a weak sealing part 18 for disturbing communication. The medical agent container 10 includes: a cylindrical part 31; a breakable part 32; a first stress giving part 34; and a second stress giving part 36. The breakable part 32 is broken by extension between the fist and second stress giving parts 34, 36 to thereby open the cylindrical part 31. The second medical agent chamber 3 is pressurized, so that the weak sealing part 13 for partitioning, the breakable part 32, and the weak sealing part 18 for disturbing communication are ripped and broken in this order in the medical container 1 with double chambers. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a medical multi-chamber container capable of adjusting and blending a drug in a drug solution such as an infusion solution.

The medical container is provided with a cylindrical body that has a closed tip and can be opened. Examples of the cylindrical body include a discharge port used at the time of administration of a drug solution and a drug container storing a drug added to the drug solution in a medical container.
Prior to infusion of the patient, mix and dissolve drugs that are difficult to pre-mix into the infusion, such as vitamins and antibiotics, in a vial or soft bag containing the infusion. Preparation of a chemical solution has been carried out. In order to prepare such a chemical solution aseptically and with a simple operation, a drug container containing a drug mixed with the chemical solution is attached to a soft bag containing the chemical solution, and the drug container is infused during infusion. There has been proposed a medical container in which a drug container and a soft bag are communicated to mix a drug and a drug solution by bending and breaking the provided weak part through a soft bag.

As such a medical container, Japanese Patent Application Laid-Open No. 2003-62038 (Patent Document 1) discloses a chemical solution container.
As shown in FIG. 1 of Japanese Patent Application Laid-Open No. 2003-62038, this chemical solution container 1 includes storage chambers 13a and 13b separated by a partition wall 12 that can be communicated, and a chemical solution storage sachet suspended in one storage chamber 13a. In the chemical solution container 10 with a chemical solution containing sachet 20 provided with 20, an easily peelable seal portion is provided on at least a part of the peripheral portion 31 of the chemical solution containing sachet 20, and the surface of at least a part of the easily peelable seal portion (cleavage portion 23) A strong seal portion 26 is formed between the wall surfaces 11 and 11b of the storage chamber 13a. Further, the weak seal portion 25 formed by adhering both wall surfaces of the storage chamber 13a is formed in connection with the strong seal portion 26. The peel strength of the partition wall 12 is set so as to be stronger than the peel strength of the cleavage portion 23 and the weak seal portion 25 and weaker than the peel strength of the strong seal portion 26.

With such a configuration, the chemical solution container 1 can reliably open the chemical solution storage pouch 10 in conjunction with the pressing of the storage chamber 13a, and the opening operation of the chemical solution storage pouch 10 is easy. Moreover, according to this chemical | medical agent container 1, when the storage chamber 13a is pressed and a partition is cleaved, not only the chemical | medical solution (other storage liquid) in each storage chamber 13a, 13b is mixed, but also in such cleavage. Interlocking with the weak seal part and the easily peelable seal part can be realized, so that the opening of the chemical solution containing sachet can be easily and reliably realized. Therefore, it is possible to avoid a situation in which the drug solution is administered without forgetting to open the drug solution containing pouch.
However, there is a risk that the drug solution container 1 can perform drug administration before the partition wall 12 is opened to mix the drug solutions in the storage chambers 13a and 13b.
JP 2003-62038 A

  Accordingly, the present invention solves the above-described problems and provides a medical multi-chamber container that prevents a drug from being administered without mixing the drugs.

The following objects are achieved.
(1) A soft bag made of a flexible material and partitioned into a first drug chamber and a second drug chamber by a partition weak seal portion from which an internal space can be peeled, and a lower end of the first drug chamber A discharge port communicating with the first portion, a first medicine stored in the first medicine chamber, a second medicine housed in the second medicine chamber, and a lower end portion of the first medicine chamber. A medical device comprising: an attached medicine container; a third medicine housed in the medicine container; and a peelable communication-inhibiting weak seal portion that inhibits communication between the first medicine chamber and the discharge port. A multi-chamber container, wherein the drug container is formed of a hard or semi-rigid material, and has a cylindrical portion whose tip is closed, and a breakable portion provided at least at the tip of the cylindrical portion. And one of the first drug chambers provided so as to sandwich the breakable portion of the cylindrical portion. And a second stress applying portion fixed to the other inner surface of the first drug chamber, and the breakable portion includes the first stress applying portion. The cylindrical portion is opened by opening the cylindrical portion, and the medical multi-chamber container pressurizes the second drug chamber to thereby form the partition. A medical multi-chamber container that peels or breaks in the order of a weak seal part for use, the breakable part, and the weak seal part for communication inhibition.
(2) In the medical multi-chamber container, the partitioning weak seal portion, the breakable portion, and the communication inhibiting weak seal portion are peeled or broken in one action by pressurizing the second drug chamber. The medical multi-chamber container according to (1).
(3) In the medical multi-chamber container, the strength for peeling or breaking increases in the order of the partition weak seal portion, the breakable portion, and the communication blocking weak seal portion. Or the medical multi-chamber container according to (2).
(4) The medical multi-chamber container has a peel strength of 2 to 6 N / 10 mm of the weak seal portion for partitioning, a peel strength of 7 to 10 N / 10 mm of the weak seal portion for communication inhibition, The medical multi-chamber container according to any one of (1) to (3), wherein the breakable portion has a breaking strength of 8 to 12N.

(5) The medical multi-chamber container is provided on both sides or both side portions of the partition weak seal portion, and includes a side weak seal portion that has higher peel strength than the partition weak seal portion and can be peeled off. When the second drug chamber is pressurized, the medical multi-chamber container includes the partition weak seal portion, the breakable portion, the communication weak seal portion, and the side weak seal portion in this order. The medical multi-chamber container according to any one of the above (1) to (4), which peels or breaks.
(6) The medical multi-chamber container is peeled or broken in order of the partition weak seal portion, the breakable portion, and the communication blocking weak seal portion in one action by pressurizing the second drug chamber. The medical multi-chamber container according to (5) above.
(7) The medical device according to any one of (1) to (6), wherein the second drug chamber of the medical multi-chamber container is filled with a larger amount of drug solution than the first drug chamber. Multi-chamber container.
(8) Any one of the above (1) to (6), wherein the second drug chamber of the medical multi-chamber container has a larger volume than the first drug chamber and is filled with a large amount of drug. A multi-chamber container for medical use according to 1.
(9) The medical multi-chamber container includes a peelable volume regulating weak seal portion provided to reduce the volume of the first drug chamber, and the medical multi-chamber container includes: By pressurizing the second drug chamber, the partition weak seal portion, the breakable portion, the communication inhibiting weak seal portion, and the volume regulating weak seal portion are peeled or broken in this order (1) to ( The medical multi-chamber container according to any one of 8).
(10) When the first drug chamber is pressurized, the medical multi-chamber container peels or breaks in the order of the partition weak seal portion, the breakable portion, and the communication blocking weak seal portion. The medical multi-chamber container according to any one of (1) to (9) above.

The medical multi-chamber container of the present invention is made of a flexible material, and has a soft bag divided into a first drug chamber and a second drug chamber by a partition weak seal part from which an internal space can be peeled, A discharge port communicating with the lower end of the first drug chamber, a first drug stored in the first drug chamber, a second drug stored in the second drug chamber, and the first A medicine container attached to the lower end of the medicine chamber, a third medicine housed in the medicine container, and a peelable communication inhibiting agent that inhibits communication between the first medicine chamber and the discharge port A medical multi-chamber container provided with a weak seal portion, wherein the drug container is formed of a hard or semi-rigid material, and has a cylindrical portion whose tip is closed, and at least the tip of the cylindrical portion. Provided to sandwich the breakable part provided and the breakable part of the tubular part, and the front A first stress applying portion fixed to one inner surface of the first drug chamber and a second stress applying portion fixed to the other inner surface of the first drug chamber; Ruptured by the spread between the first stress applying part and the second stress applying part and opening the cylindrical part, and the medical multi-chamber container further comprises the second drug chamber. By applying pressure, the partition weak seal portion, the breakable portion, and the communication inhibiting weak seal portion are peeled or broken in this order.
In this medical multi-chamber container, it is impossible to administer the drug unless the weak block part for blocking passage is peeled off, and further, the weak seal part for blocking through pressurization of the second drug chamber, The weak seal part for partitioning and the breakable part are peeled or peeled after the breakage, and the medicine is not administered without mixing the medicine.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. 1 is a front view of a medical multi-chamber container according to an embodiment of the present invention, FIG. 2 is a cross-sectional view taken along line AA of the medical multi-chamber container shown in FIG. 1, and FIGS. FIG. 6 is a front view of a drug container used in the medical multi-chamber container shown in FIG. 1, and FIG. 8 is a cross-sectional view of the drug container shown in FIG. 6 taken along the line BB, FIG. 9 is a cross-sectional view of the drug container shown in FIG. 7 taken along the line CC, and FIG. FIG. 11 is an explanatory view for explaining a method of using the medical multi-chamber container shown in FIG. In the figure, dotted lines (including lead-in lines) indicate things that are not directly visible (visible through the sheet).

  The medical multi-chamber container 1 according to the present invention is made of a flexible material, and is divided into a first drug chamber 3 and a second drug chamber 4 by a partition weak seal portion 13 whose internal space can be peeled off. The bag 2, the discharge port 7 communicating with the lower end of the first drug chamber 3, the first drug 5 stored in the first drug chamber 3, and the second stored in the second drug chamber 4. A medicine container 10 attached to the lower end of the first medicine chamber 3, a third medicine 12 housed in the medicine container 10, the first medicine chamber 3 and the discharge port 7. A weak seal portion 18 for preventing communication is provided. The drug container 10 is made of a hard or semi-rigid material, and has a cylindrical portion 31 with a closed end portion, a breakable portion 32 provided at least at the distal end portion of the cylindrical portion 31, and a cylindrical portion. The first stress applying portion 34 fixed to one inner surface 2c of the first drug chamber 3 and the other inner surface 2d of the first drug chamber 3 are provided so as to sandwich the breakable portion 32 of the first drug chamber 3, respectively. And the breakable portion 32 breaks due to the spread between the first stress applying portion 34 and the second stress applying portion 36 and opens the cylindrical portion 31. Furthermore, the medical multi-chamber container 1 is peeled or broken in the order of the partition weak seal portion 13, the breakable portion 32, and the communication blocking weak seal portion 18 by pressurizing the second drug chamber 4. It is supposed to be.

As shown in FIG. 1, the medical multi-chamber container 1 of the present invention includes a soft bag 2, a first medicine 5, a second medicine 6, a discharge port 7, a medicine container 10, and a mixed injection port 11. And.
In addition, as shown in FIG. 1, the soft bag 2 of the present invention includes a first drug chamber 3, a first drug 5 housed in the first drug chamber 3, a second drug chamber 4, The second medicine 6 accommodated in the second medicine chamber 4, the partition weak seal part 13, the side weak seal part 14, the volume regulating weak seal part 16, and the communication inhibiting weak seal part 18 The chemical solution injection unit 20 is provided.
First, the soft bag 2, the partition weak seal portion 13, the side weak seal portion 14, the volume regulating weak seal portion 16, the communication inhibiting weak seal portion 18, the drug container 10, the discharge port 7, and the mixed injection port 11 will be described. .

  An upper end side seal portion 22 and a lower end side seal portion 24 are provided at the upper end portion and the lower end portion of the flexible bag 2. The upper end side seal portion 22 and the lower end side seal portion 24 are wide and strong seal portions. Further, strong side seal portions 26 and 28 are provided on the side portions of the soft bag 2. Further, as shown in FIG. 1, a drug solution injection part 20 for injecting a drug solution into the first drug chamber 3 and a drug container attachment for attaching the drug container 10 are attached to the lower end side seal part 24 of the soft bag 2. A discharge port mounting portion 25 for mounting the portion 21 and the discharge port 7 is provided. The medicinal solution injection part 20, the medicine container attachment part 21, and the discharge port attachment part 25 are formed by not sealing a part of the lower end side seal part 24 so that the inside and outside of the soft bag penetrate (communicate). The upper end side seal portion 22 is provided with a mixed injection port mounting portion 19 for mounting the mixed injection port 11. The mixed injection port mounting portion 19 is formed by not sealing a part of the upper end side seal portion 22 so that the inside and the outside of the soft bag penetrate (communicate).

  As shown in FIG. 1, the soft bag 2 is partitioned by a partition weak seal portion 13 and side portions of the partition weak seal portion 13 or side weak seal portions 14 formed on both sides. In the embodiment of the present invention, as shown in FIG. 1, the partition weak seal portion 13 is provided so as to cross the entire lateral direction of the drug chamber of the soft bag 2, and is formed on both side portions of the partition weak seal portion 13. The side weak seal portion 14 is provided up to the side seal portions 26 and 28 of the soft bag 2. The partition weak seal portion 13 and the side weak seal portion 14 are formed by fusing the sheet material of the flexible bag 2 in a band shape. With such a configuration, only the partition weak seal portion 13 is formed near the center of the medicine chamber, and overlaps the partition weak seal portion 13 on both sides of the portion where only the partition weak seal portion 13 is formed. A side weak seal portion 14 is formed. Moreover, in the Example of this invention, the side part weak seal part 14 is a seal part whose width | variety is narrower than the weak seal part 13 for a partition. Further, as shown in FIG. 3, the medical multi-chamber container 1 may be formed such that the side weak seal portion 14 has the same width as the partition weak seal portion 13 or wider. . The medical multi-chamber container 1 may be formed by forming the partition weak seal portion 13 only near the center and forming the side weak seal portions 14 on both sides thereof.

The partition weak seal portion 13 of the embodiment peels off when the second drug chamber 4 is strongly pressurized with fingers or the like (for example, when pressed or squeezed), and is separated from the first drug chamber 3 and the second drug chamber 3. It is possible to communicate with the drug room 4. Further, the partition weak seal portion 13 is configured such that when the second drug chamber 4 is pressurized, the breakable portion 32 of the drug container 10, the weak seal portion 18 for blocking communication, the weak side seal portion 14, and the weak volume restricting portion. It is easier to peel off than the seal part 16.
Moreover, the side weak seal part 14 of an Example peels from the weak seal part 13 for a partition, the fracture | ruptureable part 32 of the chemical | medical agent container 10, and the weak seal part 18 for communication inhibition, when the 2nd chemical | medical agent chamber 4 is pressurized. Or it is hard to break.
The peeling strength of the partition weak seal portion 13 is not peeled off by the pressure applied to the soft bag 2 in the form of two-fold packaging during transportation, but when the soft bag 2 is strongly pressed (squeezed) with fingers or the like. It is preferable that it is a grade which peels. The partition weak seal portion 13 is preferably formed by fusing the soft bag 2. The fusion is preferably heat fusion, high frequency fusion, ultrasonic fusion or the like. Since the soft bag 2 has the two drug chambers 3 and 4 divided into the partition weak seal portion 13 in this way, drugs of different components can be mixed aseptically in the soft bag 2. it can. Further, in the embodiment shown in FIG. 1, the partition weak seal portion 13 is provided in a straight line horizontally with respect to the soft bag 2, but is not limited thereto. In the embodiment of the present invention, the soft bag 2 is partitioned by the partition weak seal portion 13 and the side weak seal portion 14, but is not limited thereto, and only the partition weak seal portion 13 is provided. It may be partitioned by.

The peel strength (initial peel strength) of the partition weak seal portion 13 is preferably 0.1 to 5 N / 10 mm, and more preferably 0.3 to 3 N / 10 mm. If the peel strength is within this range, the weak seal part of the partition weak seal part 13 is not accidentally peeled off during transportation or storage, and the work of peeling the partition weak seal part 13 is easy. . Further, if the peel strength is within this range, the partition weak seal portion 13 is always ahead of the breakable portion 32, the communication inhibiting weak seal portion 18, the volume regulating weak seal portion 16, and the side weak seal portion 14. Peel off.
The peel strength of the side weak seal portion 14 according to the embodiment of the present invention is larger than the peel strength or break strength of the communication inhibiting weak seal portion 18 and the breakable portion 32. Moreover, it is preferable that the side weak seal part 14 does not peel in a normal usage method. The side weak seal portion 14 is preferably formed by fusing the soft bag 2 by heat fusion, high frequency fusion, ultrasonic fusion, or the like.

The peel strength (initial peel strength) of the side weak seal portion 14 is preferably 10 N / 10 mm or more and 20 N / 10 mm or less, and particularly preferably 14 to 18 N / 10 mm. Further, the peel strength difference (initial peel strength difference) between the partition weak seal portion and the side weak seal portion is about 10 N / 10 mm or more, particularly from the peel strength (initial peel strength) of the partition weak seal portion. 16N / 10 mm larger. By doing so, when any one of the drug chambers is pressurized, it is possible to suppress the entire partition weak seal portion from being peeled at a stretch, and to ensure at least the separation from the partition weak seal portion.
A specific method for measuring the peel strength can be performed as follows. Measured value when a medical multi-chamber container is cut into 10 mm length in the width direction of the container, and each seal piece is peeled off at a pulling speed of 300 mm / min. Is the average value.

In the embodiment of the present invention, the side weak seal portions 14 are formed on both sides of the partition weak seal portion 13, but the side weak seal portions may not be formed. The soft bag 2 may be partitioned only by.
The length L of the partition weak seal portion 13 (the length excluding the side weak seal portion 14) is 47% to 60%, particularly 52% to 58%, with respect to the lateral width W of the drug chamber. preferable. Specifically, the length of the partition weak seal portion 13 is preferably 100 to 125 mm, particularly 110 to 120 mm when the width is 190 mm, although it depends on the width of the medicine chamber. Moreover, it is preferable that the length of the side weak seal part 14 is 40-55 mm, especially 45-50 mm. The width of the partition weak seal portion 13 is preferably 8 to 20 mm, particularly preferably 10 to 15 mm. Moreover, it is preferable that the width | variety of the side weak seal part 14 is 6-25 mm, especially 8-19 mm.

Since the length of the partition weak seal portion 13 is as described above, the breakable portion 32 of the drug container 10 can be easily broken in one action, and the weak seal portion 18 for inhibiting communication can be peeled off. it can.
Further, as shown in FIG. 1, the partition weak seal portion 13 is preferably provided at a position above the drug container 10 and the communication blocking weak seal portion 18. Moreover, it is preferable that the side part weak seal part 14 is provided in the both sides of the position which becomes above the chemical | medical agent container 10 and the weak seal part 18 for communication inhibition, as shown in the figure. By providing the partition weak seal portion 13 at such a position, when the partition weak seal portion 13 is peeled off, the first break stress applying portion 34 and the second break stress applying portion of the drug container 10 are provided. Since the inner surface portions 46 and 48 of the soft bag 2 to which the 36 is fixed are greatly inflated, the drug container 10 is easily broken. Similarly, when the partition weak seal portion 13 is peeled off, the portion of the soft bag 2 where the communication inhibiting weak seal portion 18 is formed swells greatly, so that the communication inhibiting weak seal portion 18 is easily peeled off.

  Note that the side weak seal portion 14 may be a seal portion that cannot be substantially peeled off (not shown). The part corresponding to the side weak seal part 14 does not necessarily have to be peeled off, and the part may be a strong seal part. The partition weak seal 13 or the side weak seal 14 may not be formed in a band shape. For example, the partition weak seal portion 13 may be formed in a V shape as shown in FIG. Moreover, the partition weak seal part may be formed in a semicircular shape or a semi-elliptical shape. Further, as shown in FIG. 5, the partition weak seal portion 13 may be easily made to peel by being made thin. Further, in this embodiment, the discharge port 7 and the communication inhibiting weak seal portion 18 are provided in the vicinity of the center of the lower portion of the soft bag, and accordingly, the partition weak seal portion 13 (the portion formed only) is also provided. It is provided near the center of the soft bag 2. When the discharge port 7 and the communication blocking weak seal portion 18 are provided at positions close to the side of the soft bag 2, the partition weak seal portion 13 (only the formed portion) is also soft. It is preferable that the bag 2 is provided at a position close to the side from the center in the lateral direction.

The volume ratio between the first drug chamber 3 and the second drug chamber 4 divided by the partition weak seal portion 13 and the side weak seal portion 14 is preferably 1: 1 to 1: 5 (first). When one drug chamber 3 is regulated by the volume regulating weak seal portion 16, the regulated volume is used).
The volume of the first drug chamber 3 of the medical multi-chamber container 1 should be as small as possible. With such a configuration, when the second drug chamber 4 is pressurized (for example, when pressed or squeezed), the breakable part 32 and the communication blocking weak seal part 18 of the drug container 10 can be performed with one action. Is easily broken or peeled off.

  The second drug chamber 4 of the medical multi-chamber container 1 preferably has a larger volume and liquid volume than the first drug chamber 3. By doing so, the stress on the breakable portion 32 of the drug container 10 and the weak seal portion 18 for inhibiting communication when the second drug chamber 4 is pressurized increases, and the breakable portion 32 of the drug container 10. Further, peeling of the weak seal portion 18 for communication inhibition becomes more reliable. Further, the amount of fluid to be filled (including the medicine and the head space (gas)) peels off the total capacity of the multi-chamber container (the partition weak seal portion 13, the side weak seal portion 14, and the volume regulating weak seal portion 16). The effect of the present invention becomes more conspicuous when it is 20 to 50% by volume of the capacity of a single room. In medical containers such as infusion bags, other drugs are co-injected. For this reason, the medical multi-chamber container is made into a bag with a reserve capacity of the same amount to several times as much as the amount of fluid to be filled. The amount of fluid in the medical container multi-chamber container having the weak seal portion for partitioning is 20 to 50% by volume. However, even with such a small fluid filling amount, according to the present invention, the medicine container 10 and communication inhibition are performed. The weak seal portion 18 is easily stressed, and both the seal portions can be opened more reliably by a single opening operation.

The soft bag 2 preferably has a water vapor barrier property. As the degree of water vapor barrier property, the water vapor permeability is preferably 50 g / m ² · 24 hrs · 40 ° C. · 90% RH or less, more preferably 10 g / m ² · 24 hrs · 40 ° C. · 90% RH or less. More preferably, it is 1 g / m ² · 24 hrs · 40 ° C. · 90% RH or less. This water vapor permeability is measured by the method described in JISK7129 (Method A).
Thus, since the soft bag 2 has a water vapor barrier property, the evaporation of moisture from the inside of the medical multi-chamber container 1 can be prevented. As a result, it is possible to prevent reduction and concentration of the medicine (specifically, chemical solution) to be filled. Moreover, the invasion of water vapor from the outside of the medical multi-chamber container 1 can be prevented.

  When polyolefin is contained as a material for forming such a flexible bag 2, the usefulness of the present invention is great. Therefore, in the present invention, it is preferable that the material for forming the flexible bag 2 contains polyolefins. Particularly preferable materials for forming the flexible bag 2 include polyolefins such as polyethylene (PE), polypropylene (PP), polybutadiene, and ethylene-vinyl acetate copolymer (EVA), styrene-butadiene copolymer and styrene. -Flexible by blending styrene thermoplastic elastomers such as ethylene-butylene-styrene block copolymers or olefinic thermoplastic elastomers such as ethylene-propylene copolymers, ethylene-butene copolymers, propylene-α olefin copolymers A softened resin may be used. This material is preferable in that it has high strength and flexibility, heat resistance (particularly heat resistance during sterilization) and water resistance, and is particularly excellent in workability and can reduce manufacturing costs.

Furthermore, when using the above blend resin, two or more kinds of materials having different melting points are used, and the upper end side seal portion 22 and the lower end side seal portion 24 of the soft bag 2, the side seal portions 26, 28, Easy setting of each seal condition of the side weak seal portion 14 of the first drug chamber 3 to be described later, the weak seal portion 13 for partition and the weak seal portion 18 for blocking communication to be described later, and stabilization of the peel strength of each seal portion And it can be achieved well.
The soft bag may have a single-layer structure (single-layer body) made of the materials described above, or a multilayer in which a plurality of layers (particularly layers of different materials) are stacked for various purposes. A laminated body may be sufficient. In the case of a multilayer laminate, a plurality of resin layers may be stacked, or a metal layer may be stacked on at least one resin layer. In the case where a plurality of resin layers are stacked, the advantages of the respective resins can be provided together. For example, the impact resistance of the soft bag 2 can be improved, or anti-blocking properties can be imparted. Moreover, in the case of a thing with a metal layer, the gas barrier property etc. of the soft bag 2 can be improved. For example, when a film such as an aluminum foil is laminated, the light barrier property can be imparted with the improvement of the gas barrier property. In addition, when a layer made of an oxide such as titanium oxide, aluminum oxide, or silicon oxide is formed, the transparency of the flexible bag 2 can be maintained while improving the gas barrier property, and the internal visibility can be secured. Can do. In addition, when the soft bag 2 is a multilayer laminated body, it is preferable that the material which forms the inner surface part is the material mentioned above.

The thickness of the sheet material constituting the flexible bag 2 is appropriately determined according to the layer configuration and the characteristics of the material used (flexibility, strength, water vapor permeability, heat resistance, etc.), and is not particularly limited. However, it is usually preferably about 100 to 550 μm, and more preferably about 200 to 400 μm. As the soft bag 2, it is desirable to use an extruded film or a blown tube having a tensile elastic modulus of 500 MPa or less, preferably 50 to 300 MPa.
The soft bag 2 is produced by blow molding using the above resin, formed by fusing the peripheral edges of two sheets formed by the resin, and one sheet formed by the resin. Any of the one formed by folding the sheet and fusing the peripheral edge, or the one formed by extrusion molding using the above resin and fusing the peripheral edge of the opening may be used. The one sheet 2a or the other sheet 2b constituting the soft bag 2 in the present invention is either a front side sheet or a back side sheet constituting the soft bag 2.

  In the drug chambers 3 and 4 of the soft bag 2, infusion agents (chemical solutions) 5 and 6 are stored. The drug chambers 3 and 4 preferably contain different components. As such an infusion, for example, two or more liquids such as peritoneal dialysis solution, transcentral vein infusion, transperipheral vein infusion, transperipheral vein injection, liquid nutrient, etc. Those that need to be mixed are preferred. Examples of the infusion include physiological saline, electrolyte solution, Ringer's solution, high calorie infusion, glucose solution, water for injection, amino acid electrolyte solution, and the like, but are not limited thereto. For example, a glucose electrolyte solution is stored in one of the drug rooms, and an amino acid solution is stored in the other, and water-soluble vitamins such as vitamin B1, vitamin B2, vitamin B6, vitamin C, panthenol, and nicotinamide are stabilized in both chambers. Can be appropriately sorted and stored. In this case, a vitamin-containing high-calorie total infusion solution can be obtained by storing a liquid preparation mainly composed of fat-soluble vitamins such as vitamin A, vitamin D, vitamin E, and vitamin K in a drug container attached to a drug room described later. .

  Further, the upper end side seal portion 22 of the soft bag 2 is provided with a hole (hanging portion) 23 for hanging on a hanger or the like. Furthermore, in order to maintain the quality of the chemical solution, a film such as an aluminum foil may be laminated on the soft bag 2 in order to impart oxygen barrier properties, light shielding properties, and the like. Further, a thin film such as a vapor deposition film made of an oxide such as titanium oxide, aluminum oxide, or silicon oxide may be formed on the surface of the soft bag 2 in order to impart oxygen barrier properties. Or you may provide the resin film which has these thin films as an intermediate | middle layer. Further, in the embodiment of the present invention, the medical multi-chamber container 1 is provided with a volume regulating weak seal portion 16 which can be peeled off by reducing the volume of the first drug chamber 3. In the embodiment shown in FIG. 1, the volume regulating weak seal portion 16 is obliquely downward from the position away from the side seal portions 26 and 28 to the side seal portions 26 and 28 on the lower side of the side weak seal portion 14. It is the strip | belt-shaped seal part formed in. As shown in FIG. 1, the volume regulation weak seal portion 16 is provided, so that the volume of the first drug chamber 3 is smaller than the state where the volume regulation weak seal portion 16 is not formed.

When the second drug chamber 4 is pressurized, the volume restricting weak seal part 16 is less likely to be peeled off than the drug container 10 and the communication blocking weak seal part 18 and is peeled to the same extent as the side weak seal part 14. It is preferable that it is easy to be peeled off or is slightly difficult to peel off. Specifically, the peel strength of the volume restricting weak seal portion 16 is preferably substantially the same as, slightly larger or slightly smaller than that of the side weak seal portion 14. The peel strength (initial peel strength) of the volume regulating weak seal portion 16 is preferably 10 to 20 N / mm, and particularly preferably 14 to 18 N / 10 mm.
Since the inner volume of the first drug chamber 3 is reduced when the partition weak seal part 13 is peeled off by having the volume restricting weak seal part 16, the second drug chamber 4 is pressurized. When this occurs, the first drug chamber 3 is reliably expanded by the inflow of the drug solution, so that the breakable portion 32 of the drug container 10 is broken and the weak seal portion 18 for blocking communication is reliably peeled off. Further, by providing the volume regulating weak seal portion 16, the breakable portion 32 and the communication inhibiting weak seal portion 18 can be easily broken or peeled off with one action. Further, since the volume restricting weak seal portion 16 can be peeled after the drug container 10 and the communication inhibiting weak seal portion 18 are broken or peeled off, the chemical solution in the multi-chamber container 1 can be reliably mixed.

The volume regulating weak seal portion 16 may have any shape as long as it regulates so as to reduce the volume of the first drug chamber 3. For example, a triangular seal portion formed below the side weak seal portion may be used. Further, the volume regulating weak seal portion 16 may be formed integrally with the side weak seal portion 14. The volume regulating weak seal portion 16 may not be formed.
The communication-inhibiting weak seal portion 18 is formed so as to surround the upper portion of the discharge port 7. A fourth chamber isolated from the first drug chamber 3 is formed by the weak seal portion 18 for inhibiting communication. This fourth room is an empty room. However, a predetermined liquid (for example, water for injection or physiological saline) may be placed in the fourth chamber. The fourth chamber may be in a dry state, but may be filled with a small amount of liquid for sterilization. Further, a passage through which some water vapor or medicine passes through the weak seal portion 18 for inhibiting communication may be formed so as to communicate with the second medicine chamber 4 at the above level. The weak seal portion 18 for inhibiting communication can be formed by heat sealing the sheet material (thermal fusion, high frequency fusion, ultrasonic fusion, etc.).

It is preferable that the communication inhibiting weak seal portion 18 is formed at a position on the lower side of the partition weak seal portion 13 (part formed only). By being formed in such a position, when the first drug chamber 3 or the second drug chamber 4 is pressurized (for example, when pressed or squeezed), as described above, the weakness for communication inhibition is set. The seal portion 18 is easily peeled off.
In the embodiment shown in FIG. 1, the weak seal portion 18 for inhibiting communication is formed in an inverted U shape. Further, the weak seal portion 18 for preventing communication has a trapezoidal shape with the short side on the upper side, a triangular shape with the discharge port at the top, a triangular shape with the discharge port at the bottom, a polygonal shape such as a quadrangle, a substantially semicircular shape, A substantially semi-elliptical shape may be used.
In the embodiment of the present invention, the weak seal portion 18 for inhibiting communication is more difficult to peel off than the breakable portion 32 of the drug container 10 and more easily peeled from the side weak seal portion 14. Moreover, the weak seal part 18 for communication inhibition may have the same breakability as the breakable part 32. Specifically, it is preferable that the peel strength of the weak seal portion 18 for inhibiting communication is substantially equal to or greater than the break strength of the breakable portion 32 of the drug container 10. Further, it is more preferable that the peeling strength of the weak seal portion 18 for inhibiting communication is slightly larger than the breaking strength of the breakable portion 32 of the drug container 10. With the configuration as described above, there is no possibility that the drug is administered in a state where the drug solution in the soft bag and the third drug 12 in the drug container 10 are not mixed.

Further, the medical container 1 may be configured such that the communication inhibiting weak seal portion 18 is peeled off after the partition weak seal portion 13 is peeled off by pressurizing the first drug chamber 3. If it is such, it can press the 1st chemical | medical agent chamber 3 of the soft bag 2, and can peel the weak seal part 18 for communication inhibition with the force of the fluid at the time of peeling of the weak seal part 13 for a partition. .
As peeling strength of the weak seal part 18 for communication inhibition, it is preferable that it is 6-10N / 10mm, especially 7-9N / 10mm.
As shown in FIG. 1, the drug container 10 is attached to a drug container attachment part 21 formed in the lower end side seal part 24 of the soft bag 2. In particular, in this embodiment, the medicine container mounting portion 21 is provided at a position closer to the left side than the vicinity of the center of the lower end side seal portion 24. The medicine container 10 may be attached to the soft bag 2 via a medicine container attachment member. Moreover, the discharge port 7 is attached to the discharge port attaching part 25 formed in the lower end side seal part 24 of the soft bag 2, as shown in FIG. The discharge port mounting portion 25 is provided at a position closer to the right side than the center of the lower end side seal portion 24. The medicine container 10 and the discharge port 7 are attached to the soft bag 2 by high-frequency fusion, thermal fusion, ultrasonic welding, or the like.

The medical multi-chamber container 1 is provided with a mixed injection port 11 for mixing chemical solutions. The mixed injection port 11 is attached to a mixed injection port attachment portion 27 formed in the upper end side seal portion 22 of the soft bag 2. In the embodiment, the mixed injection port mounting portion 27 is provided at a position close to the left side of the upper end side seal portion 22.
As shown in FIGS. 6 to 10, the drug container 10 includes a cylindrical body 30 for a medical container and a lid portion 40 that seals the rear end portion of the cylindrical body 30. Hereinafter, the drug container 10 will be described with the “upper side” in FIGS. 6 to 10 as the “front end side” and the “lower side” in FIGS. 6 to 10 as the “base end side”. As shown in FIGS. 6 to 10, the medical container tubular body 30 includes a tubular portion 31, a breakable portion 32 provided in the tubular portion 31, a first stress applying portion 34, 2 stress applying portions 36. The inside of the cylindrical portion 31 is hollow so that the third medicine 12 can be stored. As shown in FIGS. 8 and 9, the medicine storage portion 33 is formed by the inside of the cylindrical portion 31 and the tip portion of the lid portion 40.

The cylindrical part 31 has the soft bag attaching part 41 for attaching to the soft bag 2 in a base end part, as shown in FIG. 6, FIG.
As shown in FIGS. 8 and 9, the cylindrical portion 31 is a cylindrical portion whose front end portion is closed and whose proximal end portion is opened. In this embodiment, the flange portion 31 a and the first portion are sequentially formed from the proximal end side. One cylindrical portion (soft bag attaching portion) 31b, a tapered portion 31c that is continuous with the first cylindrical portion 31b and decreases in a tapered shape toward the distal end side, and a second cylindrical portion 31d that is continuous with the tapered portion 31c. And a closed portion (tip portion) 31e continuous with the second cylindrical portion 31d. The shape of the tip 31e is a truncated cone shape in the embodiment of the present invention. The shape of the tip may be a dome shape, a cone shape, or the like.
The volume of the medicine container 33 is preferably 1 to 30 mL. The length of the medicine container 33 is preferably 20 to 70 mm. Moreover, the cover part attaching part 31f which attaches the cover part 40 is formed in the base end side of the flange part 31a.

  As shown in FIGS. 8 and 9, the lid part 40 includes a disk part 40 a and a sealing part 40 b that seals an opening provided on the bottom surface side of the disk part 40 a. The blocking portion 40b is a cylindrical portion (cylindrical portion) whose proximal end is provided on the disc portion 40a and whose distal end is closed. When the lid portion 40 is attached to the proximal end portion of the tubular portion 31, the blocking portion 40 b is formed in a shape that is in close contact with the inner surface of the proximal end portion of the tubular portion 31. With such a configuration, after the medicine is stored in the cylindrical portion 31, the lid portion 40 is fitted into the lid portion attaching portion 31 f and fixed by ultrasonic fusion, high-frequency fusion, heat fusion, or the like. The part 31 can be reliably sealed.

  Examples of the medicine stored in the cylindrical portion 31 include those that are mixed and dissolved in an infusion solution. For example, antibiotics, vitamins (general vitamins), various amino acids, antithrombotic agents such as heparin, insulin, Antitumor agents, analgesics, cardiotonic agents, intravenous anesthetics, antiparkinson agents, ulcer treatment agents, corticosteroid agents, arrhythmia agents, correction electrolytes, antiviral agents, immunostimulants, and the like. Further, the inside of the cylindrical portion 31 of the medical container cylindrical body 30 may be normal pressure, but may be in a reduced pressure or vacuum state. Thus, when the inside of the cylindrical portion 31 is in a reduced pressure or vacuum state, the effect of preventing degradation, degradation, degradation, etc. of the drug is improved, and when the breakable portion 32 is broken, an infusion solution (chemical solution) is sucked, It can introduce into the cylindrical part 31 more rapidly.

  Further, when the cylindrical portion 31 is directly attached to the soft bag 2, the portion of the cylindrical portion 31 joined to the soft bag 2 (the soft bag attaching portion 41 in the embodiment of the present invention) is compatible with the soft bag 2. It is preferable to be formed of a certain resin. Thereby, the cylindrical body 30 for medical containers and the soft bag 2 become easy to adhere. In the embodiment of the present invention, a resin layer compatible with the forming material of the soft bag 2 (particularly, the forming material forming the inner surface side of the soft bag 2) is provided on the outer surface of the cylindrical portion 31 (see FIG. Not shown). Specifically, the resin layer is formed on the circumference of the outer surface of the cylindrical portion 31. Examples of compatible resins include polyolefins (eg, polyethylene, polypropylene, polybutadiene, ethylene-propylene copolymer, a mixture containing polyolefin such as a mixture of polypropylene and polyethylene or polybutene), and partially crosslinked products thereof, ethylene-vinyl acetate. A copolymer (EVA), polyester (polyethylene terephthalate, polybutylene terephthalate, etc.), soft vinyl chloride resin, polyvinyl acetate, polyvinylidene chloride, silicone, polyurethane, polyamide elastomer, polyester elastomer and the like are preferable. In addition, the compatible resin is preferably a material that is the same as or similar to the sheet material constituting the soft bag 2. The compatible resin may be coated on the cylindrical portion 31 by two-color molding. In addition, you may produce the whole chemical | medical agent storage part with resin compatible with a soft bag. You may attach to the soft bag 2 via the member for chemical | medical agent attachment. In this case, it is not necessary to provide a compatible resin layer on the outer surface of the cylindrical portion 31.

  The breakable portion 32 can vertically divide the portion of the cylindrical portion 31 constituting the medicine storage portion 33 when stress is applied by the first stress applying portion 34 and the second stress applying portion 36. It is preferable that it is the structure. The breakable portion 32 is preferably provided from the distal end portion to the vicinity of the proximal end portion of the medicine storage portion 33 (tubular portion 31). By providing the breakable portion 32 to the vicinity of the proximal end portion of the medicine storage portion 33 (tubular portion 31), when the breakable portion 32 breaks, the medicine in the medicine storage portion 33 is surely discharged. Can do. Specifically, as shown in FIG. 7, the breakable portion 32 is provided from the distal end of the medicine storage portion 33 to the vicinity of the distal end portion of the first cylindrical portion 31b. The breakable portion 32 may be formed only at the tip side portion of the cylindrical portion 31.

  The breakable portion 32 is provided so as to pass between the first stress applying portion 34 and the second stress applying portion 36 in the vicinity of the distal end portion of the cylindrical portion 31 as shown in FIGS. A distal end side portion 32a extending to the end side, a first stress applying portion side portion 32b and a second stress applying portion extending from the vicinity of the proximal end portion of the distal end side portion 32a and extending in the lateral direction of the cylindrical portion 31 It has a side portion 32c. And the 1st stress application part side part 32b and the 2nd stress application part side part 32c are provided so that the base end parts of the front end side part 32a may be connected. By comprising in this way, when the 1st stress provision part 34 and the 2nd stress provision part 36 are expanded, the fracture | ruptureable part 32 fractures | ruptures and the cylindrical part 31 is opened.

  Further, the first stress applying part 34 extends from the one sheet 2 a side part in the vicinity of the tip part of the cylindrical part 31, and the second stress applying part 36 is the other sheet in the vicinity of the tip part of the cylindrical part 31. It extends from the 2b side portion. When the second drug chamber 4 is pressurized (for example, when pressed or squeezed), the breakable portion 32 is fixed to the soft bag 2 of the first stress applying portion 34 and the second stress applying portion. When the vicinity of the fixing portion 48 of the portion 36 with respect to the soft bag 2 swells, the portion 36 breaks toward the one sheet 2a side and the other sheet 2b side. Moreover, as shown in FIG. 7, it is preferable that the front end part 32a extends between the first stress applying part 34 and the second stress applying part 36 and extends toward the base end side. The leading end portion 32a passes through the vicinity of the middle between the first stress applying portion 34 and the second stress applying portion 36 of the cylindrical portion 31, and passes through the vicinity of the middle between one sheet side and the other sheet side. It extends to the vicinity of the proximal end portion of the medicine container. The distal end side portion 32 a is formed in the vertical direction along the outer surface of the tubular portion 31 from the distal end portion to the proximal end side of the tubular portion 31. The distal end side portion 32a is formed continuously from the distal end portion to the proximal end side. With such a configuration, as shown in FIG. 11, when the second drug chamber 4 is pressurized to inflate the first drug chamber 3, the drug container 10 (cylindrical portion 31) is placed on one sheet 2 a side and It can be torn to the other sheet 2b side.

  As shown in FIG. 7, the first stress applying portion side portion 32 b and the second stress applying portion side portion 32 c of the breakable portion 32 are provided to be orthogonal to the distal end side portion 32 a of the breakable portion 32. Yes. Moreover, the opening holding member side portions 32b and 32c of the breakable portion are formed in a substantially arc shape. Since the breakable portion 32 is configured as in the embodiment shown in FIGS. 6 and 7, the tip side portion of the tubular portion 31 from the first cylindrical portion 31 b is tubular as shown in FIG. The base portion 31 is separated from the proximal end portion. The breakable portion 32 is a fragile portion that can be broken as described above. Specifically, the breakable part is a thin part. The breakable portion 32 is preferably produced by forming a groove on the outer surface of the tubular portion 31. Further, the first stress applying portion side portion 32b and the second stress applying portion side portion 32c may be formed in a substantially arc shape, a substantially elliptic arc shape, or a U-shape.

Specifically, the breakable part of the embodiment of the present invention is produced by forming a groove part having a V-shaped cross section. Specifically, the angle of the groove is preferably 30 to 120 °, particularly 40 to 60 °, and the minimum thickness is preferably 0.05 to 0.3 mm, particularly 0.08 to 0.2 mm. By producing the groove forming portion at such an angle, when the soft bag 2 is inflated, stress is concentrated at the center of the breakable portion, and the groove is reliably broken. Further, the groove portion may have any shape as long as it is easily broken, and is not limited to the V shape as in the embodiment, and may be a semicircular shape, a semielliptical shape, or the like. Moreover, although the breakable part of the present invention can be broken by forming a thin part by forming a groove part, it is not limited to this. The breakable portion may be produced by, for example, forming a portion forming the breakable portion of the medicine storage portion with a material more fragile than the other portions. Specifically, it is preferable that a part forming the breakable part is made of an easily breakable material by multicolor molding and the other parts are made of a material that is not easily broken.
Further, the breakable portion 32 may be anything as long as it can break the medicine storage portion 33 by the stress applied by the first stress applying portion 34 and the second stress applying portion 36.

  In this embodiment, the first stress applying portion 34 and the second stress applying portion 36 extend with the vicinity of the distal end portion of the cylindrical portion 31 as the base end, as shown in FIGS. Is the free end. With such a configuration, when the first stress applying unit 34 and the second stress applying unit 36 are given a force to open them, the force is converted into stress for breaking the breakable portion 32. It has a function to do. The first stress applying part 34 and the second stress applying part 36 are preferably formed to face each other. Further, the main body portions of the first stress applying portion 34 and the second stress applying portion 36 are preferably formed in a vertically long rectangular shape. With such a configuration, when the soft bag 2 is pressurized and inflated, the first stress applying portion 34 and the second stress applying portion 36 reliably apply the breaking stress to the breakable portion 32.

Specifically, as shown in FIGS. 6 to 10, the first stress applying part 34 and the second stress applying part 36 are provided on each of the vertically long flat plate parts 34a and 36a and on both sides of the flat plate parts 34a and 36a. The formed side wall portions 34b and 36b, the bonding portions 34d and 36d for bonding to the sheet constituting the flexible bag 2, the ribs 34e and 36e formed on the side wall portions, and the inner surfaces of the flat plate portions 34a and 36a. Ribs 34c and 36c and reinforcing ribs 34f and 36f are provided.
It is preferable that the first stress applying part 34 and the second stress applying part 36 are provided so as to face each other and be slightly separated from each other. Since it has such a structure, even if it presses between the 1st stress provision part 34 and the 2nd stress provision part 36 at the time of fixation to the soft bag 2, the 1st stress provision part 34 and the 1st The deformation amount allowed for the second stress applying portion 36 is small, and the breakable portion 32 is not likely to break. In the embodiment of the present invention, the flat plate portions 34a and 36a are preferably arranged so as to face each other. The side wall portions 34b and 36b of the embodiment of the present invention are formed such that the tip end portion is high and the base end portion is low. As shown in FIGS. 7 and 10, ribs 34 e and 36 e are formed on the tip side portions of the side walls 34 b and 36 b. The rib 34e and the rib 36e are provided at positions facing each other. With such a configuration, the first stress applying part 34 and the second stress applying part 36 are slightly separated from each other. The ribs are preferably separated from each other by 0.1 to 3.0 mm, particularly 0.3 to 1.5 mm.

  The ribs 34 c and 36 c are provided on the respective surfaces of the first stress applying part 34 and the second stress applying part 36 that face each other. In the embodiment of the present invention, the ribs 34c and 36c are provided from the tip of the cylindrical portion 31 of the flat plate portions 34a and 36a to the tip of the flat plate portions 34a and 36a near the center of the inner surface of the flat plate portions 34a and 36a. Yes. Further, the ribs may be arranged at positions where they do not contact each other (not shown). Specifically, the first stress applying unit 34 and the second stress applying unit 36 are staggered from the axial center of the first stress applying unit 34 or the second stress applying unit 36 to the side surface side. It may be provided at a position. For this reason, the ribs 34c and 36c do not contact each other. With such a configuration, since the tensile stress or tear stress applied to the first stress applying part 34 and the second stress applying part 36 is reliably transmitted to the breakable part 32, the breakable part 32 is broken. It becomes easy. The heights of the ribs 34c and 36c are increased from the distal end toward the proximal end side.

As shown in FIGS. 6 and 7, the reinforcing ribs 34f and 36f are provided on the outer surface of the flat plate portions 34a and 36a from the tip end portion of the cylindrical portion 31 to the vicinity of the middle portion of the flat plate portions 34a and 36a. The reinforcing ribs 34f and 36f are reduced in diameter from the distal end portion of the cylindrical portion 31 toward the distal end side. By having the reinforcing ribs 34 f and 36 f, the first stress applying portion 34 and the second stress applying portion 36 can reliably apply stress to the vicinity of the tip portion of the cylindrical portion 31.
The joining portions 34d and 36d are flat portions on the inner surface of the flexible bag 2 on the outer surfaces of the flat plate portions 34a and 36a. The joint portions 34d and 36d are formed in a rectangular shape and are flat. The joint portions 34 d and 36 d are formed at the tip side portions of the first stress applying portion 34 and the second stress applying portion 36.

  In the embodiment of the present invention, it is preferable that at least a part of the outer surface of the first stress applying part 34 and the second stress applying part 36 is formed of a material that can be fixed to the inner surface of the soft bag 2. Specifically, at least a part of the joint portions 34 d and 36 d is formed of a material that can be fixed to the inner surface of the soft bag 2. Specifically, the joint portions 34d and 36d to be joined to the inner surface of the soft bag 2 are partly or wholly formed of a material for forming the soft bag 2 (particularly, a material for forming the inner surface side of the soft bag 2). It is preferably formed of a compatible resin. With such a configuration, the first stress applying part 34 and the second stress applying part 36 can be reliably bonded to the inner surface of the flexible bag 2. The resin compatible with the soft bag 2 is preferably the resin described above. The compatible resin is preferably a material that is the same as or similar to the constituent material of the soft bag. In the embodiment of the present invention, the compatible resin layer is preferably produced by two-color molding. In addition, you may produce all the 1st stress provision parts or the 2nd stress provision part with resin compatible with the soft bag of a chemical | medical agent container. The compatible resin layer is preferably made flat so as to be easily joined to the inner surface of the soft bag.

In the medical multi-chamber container 1, as shown in FIGS. 2 and 11, the whole or part of the joining portion 34 d of the first stress applying portion 34 is joined to the sheet inner surface 2 c of the flexible bag 2. Thus, the first fixing portion 46 is formed. Similarly, the whole or a part of the joining portion 36d of the second stress applying portion 36 is joined to the sheet inner surface 2d of the flexible bag 2 to thereby form the second fixing portion 46. The fixed portion 48 is formed. For this reason, the first stress applying part 34 and the second stress applying part 36 are fixed to the first stress applying part 34 and the second stress applying part 36 of the soft bag 2 when the drug chamber is pressurized. , 48, and the breakable portion described later is opened to the one sheet 2a side and the other sheet 2b side to break.
The joining of the joining portion 34d of the first stress applying portion 34 and the joining portion 36d of the second stress applying portion 36 to one sheet inner surface 2c and the other sheet inner surface 2d of the soft bag 2 is performed by ultrasonic fusion or high frequency. It is preferably performed by fusing, heat fusing or the like. Specifically, after the drug container 10 is arranged at a position as shown in FIG. 1, it is sandwiched between both sides of one sheet 2a and the other sheet 2b of the soft bag 2 by a sealing mold and heat sealed. Are preferred.

Moreover, it is preferable that the 1st stress provision part 34 or the 2nd stress provision part 36 is the structure which can carry | support and spread from the exterior of the soft bag 2. FIG.
The first stress applying portion and the second stress applying portion of the present invention are not limited to those having the above-described configuration, and can be joined to one sheet inner surface 2c and the other sheet inner surface 2d constituting the soft bag 2. Any configuration may be used as long as it is configured to apply stress to the breakable portion in conjunction with the swelling of the soft bag. For example, it may not be formed to extend in the axial direction of the medicine container, but may be formed obliquely with respect to the medicine container.

  A hard resin or a semi-rigid resin is used as a constituent material of the cylindrical body for a medical container of the present invention. Specifically, rigid polyvinyl chloride, polyethylene, polypropylene, polybutadiene, cyclic polyolefin [specifically, ZEONEX (manufactured by ZEON Corporation), APEL (manufactured by Mitsui Chemicals, Inc.)], polypropylene homopolymer, high density polyethylene Such as polyolefin, polystyrene, poly- (4-methylpentene-1), polycarbonate, ABS resin, acrylic resin, polymethyl methacrylate (PMMA), polyacetal, polyarylate, polyacrylonitrile, polyvinylidene fluoride, ionomer, acrylonitrile-butadiene -Styrene copolymers, polyesters such as polyethylene terephthalate (PET), polybutylene terephthalate (PBT), butadiene-styrene copolymers, aromatic or aliphatic polymers. Amides of various resins, or those in which any combination of these and the like. Among these, hard polyvinyl chloride, polyethylene, polypropylene, and polyester are preferable because they are highly safe and have excellent adhesion to the soft bag 2. Moreover, the above-mentioned hard or semi-hard resin is preferable as a constituent material of the lid member and the drug container mounting member.

As shown in FIG. 1, the drug container 10 is preferably arranged at a position below the partition weak seal portion 13. By being arranged at such a position, as described above, when the first drug chamber 3 or the second drug chamber 4 is pressurized (for example, when pressed or squeezed), the drug container is broken. The possible portion 32 is easily broken.
When the second drug chamber 4 is pressurized (for example, when pressed or squeezed), the breakable portion 32 is less likely to break than the partition weak seal portion 13 and breaks from the communication inhibiting weak seal portion 18. It is easy to do. In addition, the breakable portion 32 may be as easily broken as the communication blocking weak seal portion 18. Specifically, the breaking strength of the breakable portion 32 is preferably larger than the peeling strength of the partition weak seal portion 13 and equal to or smaller than the peeling strength of the communication inhibiting weak seal portion 18. The breaking strength of the breakable portion 32 (initial breaking strength of the tip side portion 32a) is preferably 5 to 15N, and particularly preferably 8 to 12N.

  As shown in FIG. 1, it is preferable to use a known port as the discharge port 7. For example, it is preferable that the discharge port 7 includes a cylindrical port member and a seal member that seals the opening and can be inserted through the needle tube. Specifically, the port is preferably composed of a cylindrical member 7a having both ends opened and a lid portion 7b having a seal member that seals an opening on one end of the cylindrical member 7a. With such a configuration, first, the chemical solution can be injected through the cylindrical member 7 a attached to the soft bag 2.

  Moreover, it is preferable that the sealing member has a self-occlusion property, and after the needle tube is extracted from the elastic body, the puncture hole is closed to prevent the leakage of the chemical solution. Examples of the constituent material of the sealing material include polyolefins such as polyethylene, polypropylene, ethylene-propylene copolymer, ethylene-vinyl acetate copolymer, and cross-linked ethylene-vinyl acetate copolymer, polyester, polyvinyl chloride, polyurethane, Flexible polymer materials such as polyamide, thermoplastic resins such as polyamide elastomer and polyester elastomer (thermoplastic elastomer), natural rubber, isoprene rubber, silicone rubber, butadiene rubber, various rubber materials such as styrene-butadiene rubber, etc. An elastic material or a combination of any two or more of these materials can be used, and those containing an elastic material are preferable from the viewpoint of sealing performance and resealability. Moreover, as a port, it is preferable that it is a cylindrical and elliptical cylinder-shaped molded article. The constituent material of the discharge port 7 is preferably the same as that of the drug container.

  As shown in FIG. 1, it is preferable to use a well-known port for the mixed injection port 11. For example, it is preferable to include a cylindrical port member and a seal member that seals the opening and can be inserted through the needle tube. Specifically, the port preferably has the same configuration as that of the discharge port 7, and has a cylindrical member 11a that is open at both ends, and a lid that has a seal member that seals the opening at one end of the cylindrical member 11a. It is preferable that it consists of the part 11b. With such a configuration, first, the chemical solution can be injected through the cylindrical member 11 a attached to the soft bag 2.

Next, the medical multi-chamber container 1 is peeled or broken in the order of the partition weak seal portion 13, the breakable portion 32, and the communication blocking weak seal portion 18 by pressurizing the second drug chamber 4. Will be described. The medical multi-chamber container 1 of the present invention has such a configuration, so that the first medicine 5 in the first medicine chamber 3 and the second medicine 6 in the second medicine chamber 4 are provided. It is possible to prevent the drug from being administered before the drug is mixed and before the drug in the drug chamber and the drug in the drug container 10 are mixed.
As such a medical multi-chamber container 1, specifically, the peeling strength or breaking strength may increase in the order of the partition weak seal portion 13, the breakable portion 32, and the communication blocking weak seal portion 18. preferable.

  Moreover, it is preferable that the weak seal part 18 for communication inhibition begins to peel after the breakable part 32 is broken, and peels completely after the breakable part 32 is completely broken. The weak seal portion 18 for inhibiting communication begins to peel after the breakable portion 32 is broken, and when the breakable portion 32 is completely broken, the weak seal portion 18 for preventing communication is peeled by about 70 to 90%. It is preferable. With such a configuration, in particular, the drug is not administered in a state where the drug solution in the soft bag and the third drug 12 in the drug container 10 are not mixed.

Further, the medical multi-chamber container 1 includes a detachable side weak seal portion 14 provided on both sides or both side portions of the partition weak seal portion 13 and pressurizes the second drug chamber 4 (for example, , It is preferable that the partition weak seal portion 13, the breakable portion 32, the communication blocking weak seal portion 18, and the side weak seal portion 14 are peeled or broken in this order.
In such a medical multi-chamber container 1, the peeling strength or breaking strength increases in the order of the partition weak seal portion 13, the breakable portion 32, the communication blocking weak seal portion 18, and the side weak seal portion 14. It is preferable to go. As described above, the side weak seal portion 14 is more difficult to peel off than the partition weak seal portion 13, the breakable portion 32, and the communication blocking weak seal portion 18, thereby pressurizing the second drug chamber 4. When it is pressed (for example, when pressed or squeezed), the partition weak seal portion 13 becomes a peeling portion, and the side weak seal portion 14 does not peel off. Therefore, the capacity of the first drug chamber 3 does not increase so much. In the state, it receives an inflow of fluid such as liquid. Therefore, the first medicine chamber 3 is reliably expanded, and the medicine container 10 and the communication blocking weak seal portion 18 are surely broken or peeled accordingly.

Further, as described above, the medical multi-chamber container 1 includes the peelable volume regulating weak seal portion 16 provided so as to reduce the volume of the first drug chamber 3, and the second drug chamber 4. Can be peeled or broken in the order of the partition weak seal portion 13, the breakable portion 32, the communication blocking weak seal portion 18, and the volume regulating weak seal portion 16. preferable.
As such a medical multi-chamber container 1, the partition weak seal portion 13, the breakable portion 32, the communication blocking weak seal portion 18, the side weak seal portion 14, and the volume regulating weak seal portion 16 are peeled in this order. The strength or breaking strength is preferably increased.

In addition, the medical multi-chamber container 1 of the embodiment of the present invention includes the side weak seal portion 14 and the volume regulating weak seal portion 16 as described above, and pressurizes the second drug chamber 4 (for example, , Pressing or squeezing), the partition weak seal portion 13, the breakable portion 32, the communication blocking weak seal portion 18, the side weak seal portion 14, and the volume regulating weak seal portion 16 are peeled or broken in this order. ing.
As such a medical multi-chamber container 1, the partition weak seal portion 13, the breakable portion 32, the communication blocking weak seal portion 18, the side weak seal portion 14, and the volume regulating weak seal portion 16 are peeled in this order. The strength or breaking strength is preferably increased.

In addition, the medical multi-chamber container 1 of the embodiment of the present invention includes the side weak seal portion 14 and the volume regulating weak seal portion 16 as described above, and pressurizes the second drug chamber 4 (for example, , Pressing or squeezing), the partition weak seal portion 13, the breakable portion 32, the communication inhibiting weak seal portion 18, the volume regulating weak seal portion 16, and the side weak seal portion 14 are peeled or broken in this order. It may be a thing.
As such a medical multi-chamber container 1, the partition weak seal portion 13, the breakable portion 32, the communication inhibiting weak seal portion 18, the volume regulating weak seal portion 16, and the side weak seal portion 14 are peeled in this order. The strength or breaking strength is preferably increased.
Further, the side weak seal portion 14 and the volume regulating weak seal portion 16 may be peeled off almost simultaneously by pressurizing the second drug chamber 4.

In such a case, it is preferable that the peel strength of the side weak seal portion 14 and the peel strength of the volume restricting weak seal portion 16 are substantially equal.
Further, the medical multi-chamber container 1 is peeled or broken in the order of the weak seal portion 13 for partitioning, the breakable portion 32, and the weak seal portion 18 for blocking communication in one action by pressurizing the second drug chamber 4. It is preferable that By having such a configuration, before the first medicine 5 in the first medicine chamber 3 and the second medicine 6 in the second medicine chamber 4 are mixed, and in the medicine chamber The medicine can be prevented from being administered before the medicine in the medicine container 10 is mixed, and preparation for medicine administration can be easily performed.

Specifically, the medical multi-chamber container 1 has a peel strength of the partition weak seal portion 13 of 2 to 3 N / 10 mm, a peel strength of the weak seal portion 18 for communication inhibition of 7 to 9 N / 10 mm, and the drug container 10 is broken. The breaking strength of the possible portion 32 is preferably 8 to 12N. With such peel strength or breaking strength, the drug before the first drug 5 in the first drug chamber 3 and the second drug 6 in the second drug chamber 4 are mixed and the drug in the drug chamber. When the drug is prevented from being administered before the drug in the drug container 10 is mixed, the second drug chamber 4 is pressurized (for example, when pressed or squeezed). In addition, the partition weak seal portion 13, the breakable portion 32, and the communication blocking weak seal portion 18 can be easily peeled off or broken in one action.
Moreover, the medical multi-chamber container 1 pressurizes (for example, presses or squeezes) the second drug chamber 4 with a single action, so that the partition weak seal portion 13, the breakable portion 32, and the communication inhibiting weak seal. The part 18 and the side weak seal part 14 are preferably peeled or broken in this order.

  Specifically, the medical multi-chamber container 1 has a peel strength of the partition weak seal portion 13 of 2 to 3 N / 10 mm, a peel strength of the weak seal portion 18 for communication inhibition of 7 to 9 N / 10 mm, and the drug container 10 is broken. The breaking strength of the possible portion 32 is preferably 8 to 12 N, and the peel strength of the side weak seal portion 14 is preferably 14 to 18 N / 10 mm. With such peel strength or breaking strength, the drug before the first drug 5 in the first drug chamber 3 and the second drug 6 in the second drug chamber 4 are mixed and the drug in the drug chamber. And the medicine in the medicine container can be prevented from being administered before being mixed, and when the second medicine chamber 4 is pressurized (for example, when pressed or squeezed). The partition weak seal portion 13, the breakable portion 32, and the communication blocking weak seal portion 18 can be easily peeled off or broken with one action.

Moreover, the medical multi-chamber container 1 pressurizes (for example, presses or squeezes) the second drug chamber 4 with a single action, so that the partition weak seal portion 13, the breakable portion 32, and the communication inhibiting weak seal. The part 18, the side weak seal part 14, and the volume regulating weak seal part 16 are preferably peeled or broken in this order.
Specifically, the medical multi-chamber container 1 has a peel strength of the partition weak seal portion 13 of 2 to 3 N / 10 mm, a peel strength of the weak seal portion 18 for communication inhibition of 7 to 9 N / 10 mm, and the drug container 10 is broken. The breaking strength of the possible portion 32 is preferably 8 to 12 N, the peel strength of the side weak seal portion 14 is 14 to 18 N / 10 mm, and the peel strength of the volume restricting weak seal portion 16 is preferably 14 to 18 N / 10 mm. With such peel strength or breaking strength, the drug before the first drug 5 in the first drug chamber 3 and the second drug 6 in the second drug chamber 4 are mixed and the drug in the drug chamber. When the drug is prevented from being administered before the drug in the drug container 10 is mixed, the second drug chamber 4 is pressurized (for example, when pressed or squeezed). In addition, the partition weak seal portion 13, the breakable portion 32, and the communication blocking weak seal portion 18 can be easily peeled off or broken in one action.

  Further, the medical multi-chamber container 1 has a partition weak seal portion even when the first drug chamber 3 is pressurized rather than the second drug chamber 4 (for example, when pressed or squeezed). It is preferable that 13 is peeled off and the breakable portion 32 of the medicine container 10 and the weak seal portion 18 for communication inhibition are not peeled off. As such a medical multi-chamber container 1, when the first drug chamber 3 is pressurized, the partition weak seal portion 13 is peeled off, and the breakable portion 32 of the drug container 10 and the weak seal for preventing communication are provided. It is preferable that the peeling or breaking strength of the weak seal portion 18 for blocking communication and the breakable portion 32 is larger than the peeling strength of the weak seal portion 13 for partitioning to the extent that the portion 18 does not break or peel.

In addition, as a specific method for measuring the peel strength described above, a portion including each measurement target seal portion of the medical multi-chamber container is cut into a length of 10 mm in the width direction of the container, and the respective pieces are sealed. This is done by calculating the average value of the measured values when the part is peeled off at a tensile speed of 300 mm / min.
Moreover, the measuring method of the breaking strength of the breakable portion 32 of the drug container 10 described above fixes the main body portion of the drug container 10 and the tips of the first break stress applying portion 34 and the second break stress applying portion 36. The stress is applied to the surface in the tearing direction, and the stress is measured when the tip end portion 32a of the breakable portion 32 is broken.
In all the above-described embodiments, when the first drug chamber is pressurized, the medical multi-chamber container is a partition weak seal portion, a breakable portion, a communication blocking weak seal portion in order or a breakable portion. It is preferable that the weak seal part for partitioning and the weak seal part for communication inhibition are peeled or broken in this order.

Next, the manufacturing method of the medical multi-chamber container 1 of this invention is demonstrated using FIG. The method is not limited to this method.
First, a tube body formed of a soft synthetic resin is prepared. And the upper end side seal part 22 which has one part unsealed part (mixed injection port attachment part 19) in this tube body, three part unsealed parts (discharge port attachment part 25, chemical | medical agent container attachment part 21, chemical | medical solution) A lower end side seal portion 24 having an injection portion 20), side seal portions 26 and 28, a partition weak seal portion 13, a side weak seal portion 14, a communication inhibiting weak seal portion 18, and a volume regulating weak seal. The soft bag 2 is formed by forming the portion 16. Subsequently, the discharge port 7 is inserted and fixed to the discharge port mounting portion 25 which is a partially unsealed portion of the lower end side seal portion 24, and the drug container 10 containing the third drug 12 is inserted into the drug container mounting portion 21. And stick.

Then, the cylindrical member 11a of the co-injection port 11 is fixed to the partially unsealed portion of the upper end side seal portion 22, and the second medicine 6 is injected through the cylindrical member 11a. In a state where the container is fixed, the cap member 11b with the elastic member attached to the cylindrical member 11a is fixed and sealed. And after inject | pouring the 1st chemical | medical agent 5 from the chemical | medical solution injection | pouring part 20 which is a partially unsealed part of the lower end side seal part 24, it seals.
In this way, a medical multi-chamber container filled with a medicine as shown in FIG. 1 is produced. The injection of the first drug 5 and the sealing operation of the first drug chamber 3 may be performed before the injection of the second drug 6 and the sealing operation of the second drug chamber. As a method of forming the partition weak seal portion 13 and the side weak seal portion 14, the heat seal condition of the partition weak seal portion 13 is set to be strong only in the portion that becomes the side weak seal portion 14 or the side portion. Only the portion that becomes the weak seal portion 14 can be performed by performing the heat treatment again. Specifically, heat sealing is performed once using a heating mold under the sealing conditions (temperature, pressure, and time are adjusted) so that the entire width direction becomes the peel strength of the weak sealing portion for partitioning, and then the side portion is weak. Forming a portion having a high peel strength by performing heat treatment again using a heating mold under seal conditions (temperature, pressure, and time are adjusted) so that the region to be the seal portion 14 has a desired peel strength. Can do.

  Next, the usage method of the medical multi-chamber container 1 of this invention is demonstrated using FIG. 1, FIG. First, when the second drug chamber 4 of the medical multi-chamber container 1 is pressurized (gripped from both sides in the embodiment), the partition weak seal portion 13 is first peeled off. As a result, the first medicine 5 in the first medicine chamber 3 and the second medicine 6 in the second medicine chamber 4 are mixed. Next, the medicine in the second medicine chamber 4 flows into the first medicine chamber 3 and the first medicine chamber 3 swells, and in conjunction therewith, the first stress applying section 34 and the second stress applying The portion 36 opens in the direction of one sheet 2a and the other sheet 2b constituting the soft bag 2, and first the distal end portion 32a of the breakable portion 32 is broken, and then the first stress applying portion side portion 32b and the second portion The second stress applying portion side portion 32c is broken. Thereby, the medicine container 33 of the medicine container 10 is opened, and the third medicine 12 in the medicine container 10 and the medicine solution in the soft bag 2 are mixed. After that, the communication inhibiting weak seal portion 18 is peeled off in conjunction with the swelling of the first drug chamber 3 after the break of the drug container 10. Thereafter, when the internal pressure in the soft bag 2 is further increased by pressurizing (for example, pressing or squeezing) the second drug chamber 4, the side weak seal portion 14 is peeled off, and then the volume regulating seal portion. 16 peels off. Thus, according to the medical multi-chamber container 1 of the present invention, the first medicine 5 in the first medicine chamber 3, the second medicine 6 in the second medicine chamber 5, and the medicine in the medicine chamber It is possible to prevent the medicine from being administered in a state where the third medicine 12 in the medicine container 10 is not mixed.

In the medical multi-chamber container 1 of the present invention, the first drug chamber 3 is first pressurized (for example, pressed or squeezed), and then the second drug chamber 4 is pressurized (for example, pressed). Alternatively, the partition weak seal 13, the breakable portion 32 of the drug container 10, and the communication blocking weak seal 18 can be broken or peeled in this order.
Specifically, first, when the first drug chamber 3 is pressurized (for example, pressed or squeezed), the breakable portion 32 of the drug container 10 and the weak seal portion 18 for communication inhibition are not broken or peeled off. The weak seal portion 13 for partitioning peels off. As a result, the first medicine 5 in the first medicine chamber 3 and the second medicine 6 in the second medicine chamber 4 are mixed. Next, by increasing the internal pressure in the first drug chamber 3 by applying pressure from the second drug chamber 4 side, the breakable portion 32 of the drug container 10 is broken as described above. The weak seal 18 is peeled off.

When the breakable portion 32 is broken, the drug solution in the third drug 12 in the drug container 10 and the soft bag 2 are mixed. Further, when the internal pressure in the soft bag 2 is increased by pressurizing (for example, pressing or squeezing) the second drug chamber 4, the side weak seal portion 14 is peeled off, and then the volume regulating seal. The part 16 peels off. Thus, according to the medical multi-chamber container 1 of the present invention, even if the first medicine chamber 3 is initially pressurized (for example, even if it is pressed or squeezed), the first medicine chamber The first medicine 5 in 3, the second medicine 6 in the second medicine chamber 5, the medicine in the medicine chamber and the third medicine 12 in the medicine container 10 are unmixed. This can be prevented.
The medical multi-chamber container of the present invention has been described above, but is not limited to the above.

FIG. 1 is a front view of a medical multi-chamber container according to an embodiment of the present invention. FIG. 2 is a cross-sectional view of the medical multi-chamber container shown in FIG. FIG. 3 is an explanatory diagram for explaining an example of another partition weak seal portion for a medical multi-chamber container. FIG. 4 is an explanatory diagram for explaining an example of another partition weak seal portion for a medical multi-chamber container. FIG. 5 is an explanatory diagram for explaining an example of another partition weak seal portion for a medical multi-chamber container. FIG. 6 is a front view of a medicine container used for the medical multi-chamber container shown in FIG. FIG. 7 is a side view of the medicine container shown in FIG. FIG. 8 is a cross-sectional view of the drug container shown in FIG. FIG. 9 is a cross-sectional view of the drug container shown in FIG. FIG. 10 is a top view of the drug container of FIG. FIG. 11 is an explanatory diagram for explaining a method of using the multi-chamber container shown in FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Medical container 2 Soft bag 2c One inner surface 2d of a 1st chemical | medical agent chamber The other inner surface 3 of a 2nd chemical | medical agent chamber 4 The 1st chemical | medical agent chamber 4 The 2nd chemical | medical agent chamber 5 The 1st chemical | medical agent 6 The 2nd chemical | medical agent 7 Discharge port 10 Drug container 12 Third drug 13 Weak seal part 18 for partitioning Weak seal part 31 for blocking communication Cylindrical part 32 Breakable part 34 First stress applying part 36 Second stress applying part 46 Fixing part 48 Fixing Part

Claims (10)

A soft bag made of a flexible material and separated into a first drug chamber and a second drug chamber by a partition weak seal part that can be separated from the internal space, and communicated with the lower end of the first drug chamber Attached to the lower end of the first medicine chamber, the first medicine housed in the first medicine chamber, the second medicine housed in the second medicine chamber A medical multi-chamber comprising a medicine container, a third medicine accommodated in the medicine container, and a peelable communication-inhibiting weak seal portion that inhibits communication between the first medicine chamber and the discharge port The drug container is made of a hard or semi-rigid material, and has a cylindrical part with a closed tip, a breakable part provided at least at the tip of the cylindrical part, and the cylinder One inner surface of the first drug chamber is provided so as to sandwich the breakable portion of the shape portion A first stress applying portion fixed and a second stress applying portion fixed to the other inner surface of the first drug chamber, and the breakable portion includes the first stress applying portion and the first stress applying portion. 2 is opened by opening the cylindrical portion, and the medical multi-chamber container pressurizes the second drug chamber to form the partition weak seal. The medical multi-chamber container is characterized in that it peels or breaks in the order of the part, the breakable part, and the weak seal part for communication inhibition. 2. The medical multi-chamber container according to claim 1, wherein the partitioning weak seal part, the breakable part, and the communication-inhibiting weak seal part are peeled off or broken in one action by pressurizing the second drug chamber. The medical multi-chamber container as described. 3. The medical multi-chamber container according to claim 1 or 2, wherein the strength for peeling or breaking increases in the order of the partition weak seal portion, the breakable portion, and the communication blocking weak seal portion. The medical multi-chamber container as described. The medical multi-chamber container has a peel strength of 2 to 6 N / 10 mm of the weak seal portion for partitioning, a peel strength of 7 to 10 N / 10 mm of the weak seal portion for communication inhibition, and the breakable portion of the drug container. The medical multi-chamber container according to any one of claims 1 to 3, wherein the breaking strength is 8 to 12N. The medical multi-chamber container is provided on both sides or both side portions of the partition weak seal portion, and includes a side weak seal portion having a peel strength higher than the partition weak seal portion and capable of being peeled off. When the second drug chamber is pressurized, the multi-chamber container is peeled or broken in the order of the partition weak seal portion, the breakable portion, the communication blocking weak seal portion, and the side weak seal portion. The medical multi-chamber container according to any one of claims 1 to 4. 6. The medical multi-chamber container is peeled or broken in order of the partition weak seal part, the breakable part, and the communication-inhibiting weak seal part in one action by pressurizing the second drug chamber. A multi-chamber container for medical use according to 1. The medical multi-chamber container according to any one of claims 1 to 6, wherein the second drug chamber of the medical multi-chamber container is filled with a larger amount of drug solution than the first drug chamber. 7. The medical compound chamber according to claim 1, wherein the second drug chamber of the medical multi-chamber container has a larger volume than that of the first drug chamber and is filled with a large amount of drug. Chamber container. The medical multi-chamber container includes a peelable volume regulating weak seal portion provided to reduce the volume of the first drug chamber, and the medical multi-chamber container includes the second medical chamber The pressurization of the medicine chamber causes the partition weak seal portion, the breakable portion, the communication inhibiting weak seal portion, and the volume regulating weak seal portion to peel or break in this order. The medical multi-chamber container as described. The medical multi-chamber container peels or breaks in order of the partition weak seal portion, the breakable portion, and the communication blocking weak seal portion when the first drug chamber is pressurized. Item 10. A medical multi-chamber container according to any one of Items 1 to 9.

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