JP2006513670A - Data communication method through human body, data communication system through human body, and sensing device used therefor - Google Patents
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Abstract
【課題】本発明は、人体を通じたデータ通信方法及び人体を通じたデータ通信システム、並びにこれらに使用される感知装置を提供する。
【解決手段】本発明は、人体を導体とし、信号を電圧の極性とし、低周波、低電流及び電圧極性を使用して、人体を通じて、該人体の外部の受信器に情報を送信する。これにより、人体に無害で消費電力が少なく、受信感度に優れた人体を通じた通信方法及び人体を通じた通信システムを提供することができるようになる。また、本発明は、人体を通じた通信方法及び人体を通じた通信システムに使用される感知装置として、無線送信器及びアンテナを必要とせず、CMOSイメージセンサに全ての回路が集積されている、安価かつコンパクトなカプセル型内視鏡をも提供する。The present invention provides a data communication method through a human body, a data communication system through a human body, and a sensing device used therefor.
The present invention transmits information through a human body to a receiver external to the human body using a human body as a conductor, a signal as a voltage polarity, and using low frequency, low current and voltage polarity. As a result, it is possible to provide a communication method through the human body and a communication system through the human body that are harmless to the human body, consume less power, and have excellent reception sensitivity. In addition, the present invention is a low-cost, low-cost, all-circuit integrated circuit in a CMOS image sensor that does not require a wireless transmitter and antenna as a sensing device used in a communication method through a human body and a communication system through a human body. A compact capsule endoscope is also provided.
Description
本発明は、様々な医療情報の収集を目的として人体の内部に投入された感知装置が、人体の外部にデータを送信する方法及びシステムに関し、より詳細には、感知装置から発生した電流が人体を導体として流れることにより、人体の外部にデータを送信し得る人体を通じたデータ通信方法、人体を通じたデータ通信システム、及びこれらに使用される感知装置に関する。 The present invention relates to a method and system in which a sensing device inserted into a human body for the purpose of collecting various medical information transmits data to the outside of the human body, and more particularly, a current generated from the sensing device is a human body. The present invention relates to a data communication method through a human body capable of transmitting data to the outside of the human body by flowing as a conductor, a data communication system through the human body, and a sensing device used for these.
人体の内部の医療情報を収集する様々な感知装置が開発され、使用されているが、このような情報収集技術だけでなく、収集した情報を人体の外部に送信する技術も非常に重要である。 Various sensing devices that collect medical information inside the human body have been developed and used. In addition to such information collection technology, technology that transmits the collected information to the outside of the human body is also very important. .
一般的なデータ送信方法としては、胃腸の内部状態を観察するための目的で開発された内視鏡に適用される通信ケーブル方式がある。この通信ケーブル方式においては、導線又は光ファイバーからなるケーブルを、主に患者の喉を通して人体の内部に挿入する。このような通信ケーブル方式は、信頼性が高く、人体の内部で収集されたデータの品質に優れるという利点がある。しかし、内視鏡施術を受ける患者にひどい苦痛を与えるという問題があった。 As a general data transmission method, there is a communication cable method applied to an endoscope developed for the purpose of observing the internal state of the gastrointestinal tract. In this communication cable system, a cable made of a conducting wire or an optical fiber is inserted into the human body mainly through the patient's throat. Such a communication cable system has the advantages of high reliability and excellent quality of data collected inside the human body. However, there has been a problem of severe distress to patients undergoing endoscopic procedures.
このような問題を解決するために、近年、イスラエルのギブン・イメージング(Given Imaging)社が、カプセル型内視鏡「M2A」を開発した。前記カプセル型内視鏡は、患者が錠剤のように飲み込むと、カプセル型内視鏡が、内視鏡のカメラに捉えた人体の内部の映像(ビデオ)データを外部の受信器に送信して、モニタで再生することができる。 In order to solve such problems, Israel's Given Imaging has recently developed a capsule endoscope “M2A”. When the patient swallows the tablet like a tablet, the capsule endoscope sends video (video) data inside the human body captured by the camera of the endoscope to an external receiver. Can be played on the monitor.
しかしながら、前記カプセル型内視鏡は、信号送信方式として無線電波方式を採用するため、消費電力が大きくて動作時間が短い。また、人体の外部の各種電波干渉により受信感度が劣化する。さらに、映像信号を高周波信号に変調する変調回路や信号を送信するためのアンテナなどの無線送信器を備えなければならないので、サイズが大きくなり、かつ生産コストが上昇する。さらにまた、高周波の使用により、人体に有害な影響を及ぼす恐れがあるという問題があった。 However, since the capsule endoscope employs a radio wave system as a signal transmission system, the power consumption is large and the operation time is short. In addition, the reception sensitivity deteriorates due to various radio wave interference outside the human body. Furthermore, since a modulation circuit that modulates a video signal into a high-frequency signal and a wireless transmitter such as an antenna for transmitting the signal must be provided, the size increases and the production cost increases. Furthermore, there is a problem that the use of high frequency may cause harmful effects on the human body.
従って、本発明は、このような従来の課題に鑑みてなされたもので、人体の内部に投入された感知装置が発生する電流を、人体を導体として流し、人体の外部にデータを送信できるようにした人体を通じたデータ通信方法及び人体を通じたデータ通信システムを提供することを目的とする。 Accordingly, the present invention has been made in view of such a conventional problem, and allows a current generated by a sensing device inserted into the human body to flow using the human body as a conductor and transmit data to the outside of the human body. It is an object of the present invention to provide a data communication method through a human body and a data communication system through a human body.
また、本発明の他の目的は、人体の内部で電流を発生し、人体を通して電流を流すことにより人体の外部にデータを送信する送信電極を含む感知装置を提供することにある。 Another object of the present invention is to provide a sensing device including a transmission electrode that generates a current inside the human body and transmits data to the outside of the human body by flowing the current through the human body.
このような目的を達成するために、本発明に係る人体を通じたデータ通信方法は、人体の内部に投入された感知装置から、信号を、人体の外部へ送信する人体を通じたデータ通信方法において、前記感知装置の表面に設置された送信電極間に電位差を発生させる段階と、相対的に高い電位を有する送信電極から、電流を、人体の内部へ供給して、人体の表面に流した後、再び人体の内部に流れ込む電流を、相対的に低い電位を有する送信電極にシンク(sink)させる段階と、前記人体の表面を流れる電流により、人体の表面に装着された受信電極間に電圧を誘起する段階と、を含むことを特徴とする。 In order to achieve such an object, a data communication method through a human body according to the present invention is a data communication method through a human body that transmits a signal to the outside of the human body from a sensing device input into the human body. A step of generating a potential difference between the transmission electrodes installed on the surface of the sensing device, and a current is supplied to the inside of the human body from the transmission electrode having a relatively high potential, and after flowing through the surface of the human body, The step of sinking the current flowing into the human body again to the transmitting electrode having a relatively low potential, and the current flowing through the surface of the human body induces a voltage between the receiving electrodes attached to the surface of the human body. And a step of performing.
また、本発明に係る人体を通じたデータ通信システムは、人体の内部に投入されて電位差を発生する送信電極を備える感知装置と、人体の表面に装着されて前記電位差により発生した電流を人体を通して受信する受信器と、を含むことを特徴とする。 In addition, the data communication system through the human body according to the present invention includes a sensing device including a transmission electrode that is inserted into the human body to generate a potential difference, and receives current generated by the potential difference that is attached to the surface of the human body through the human body. And a receiver.
また、本発明に係る感知装置は、人体の内部を照射する照明素子と、人体の内部から入射した光を集束するレンズと、前記レンズにより集束された光から電気信号を生成するCMOSイメージセンサと、前記照明素子、前記レンズ及び前記CMOSイメージセンサを収容するハウジングと、前記ハウジングの表面に設置されて前記電気信号が印加される送信電極と、を含むことを特徴とする。 A sensing device according to the present invention includes an illumination element that irradiates the inside of a human body, a lens that focuses light incident from the inside of the human body, and a CMOS image sensor that generates an electrical signal from the light focused by the lens. And a housing for housing the illumination element, the lens and the CMOS image sensor, and a transmission electrode installed on a surface of the housing and applied with the electrical signal.
以下、添付の図面を参照して本発明の好ましい一実施形態を説明する。 Hereinafter, a preferred embodiment of the present invention will be described with reference to the accompanying drawings.
図1は、本発明に係る人体を通じたデータ通信方法及び人体を通じたデータ通信システムを説明するための一実施形態を示した図である。図1に示したように、人体の内部1(例えば、消化器官)に位置した感知装置10は、人体2を通して人体の表面に設置された受信器20に、人体の内部の情報を送信する。
FIG. 1 is a diagram illustrating an embodiment for explaining a data communication method through a human body and a data communication system through a human body according to the present invention. As shown in FIG. 1, the
本発明に係る人体を通じたデータ通信システムにおいて、人体の内部1の感知装置10から、信号を、人体の外部の受信器20へ送信する人体を通じたデータ通信方法を、図1を参照して具体的に説明する。感知装置10により収集された各種情報(例えば、人体の内部の画像、PH、温度又は電気的インピーダンスなど)は、感知装置内部の信号処理回路により電気信号に変換された後、前記信号処理回路の出力線を通して送信電極11に印加されて、2つの送信電極11間に電位差が発生する。これは、送信電極11が、人体の内部1と接触しているためであり(即ち、送信電極が消化器官内の体液により人体と電気的に接続されている)、2つの送信電極11間の電位差により、人体2に電流3が流れるからである。電流3は、相対的に高い電位を有する送信電極から流されて、人体2の表面を流れた後、再び人体の内部1へと戻り、相対的に低い電位を有する送信電極にシンクされる。このとき、人体の表面を流れる電流が2つの受信電極21間に電圧を誘起することにより、人体の内部1に位置した感知装置10から送信された信号が人体の外部の受信器20で感知できるようになる。受信器20は、受信信号を処理して映像信号に復元し、これをリアルタイムでモニタにディスプレイするか、又はメモリに保存する。
In the data communication system through the human body according to the present invention, a data communication method through the human body for transmitting a signal from the
図2は、本発明に係る人体を通じたデータ通信システムに使用される感知装置10の表面上に設置される送信電極11のいくつかの実施形態を示す。後述するように、感知装置10の表面には、感知装置の内部に設けられた信号処理回路の出力線にそれぞれ接続された2つの金属板、即ち、送信電極が形成されている。
FIG. 2 shows several embodiments of the transmitting
2つの送信電極が、電気的に絶縁されており、互いの距離が十分に離れていれば、送信電極を、感知装置の表面のあらゆる位置に形成することができる。また、常に人体と接触しやすくするために、感知装置を覆う形状、即ち、3次元の曲線形状に形成することが好ましい。 If the two transmission electrodes are electrically isolated and are sufficiently far apart from each other, the transmission electrodes can be formed at any location on the surface of the sensing device. Moreover, in order to always make it easy to contact a human body, it is preferable to form in the shape which covers a sensing device, ie, a three-dimensional curve shape.
図2において、(a)は、図1で使用した感知装置の送信電極の構造を示したもので、送信電極が感知装置の両端をそれぞれ囲む第1電極及び第2電極を含んで構成されている。(b)における送信電極は、感知装置の一端を囲む第1電極と、感知装置の他端を帯状に覆う第2電極と、を含んで構成されている。(c)における送信電極は、感知装置の両端をそれぞれ帯状に覆う第1電極及び第2電極を含んで構成されている。また、(d)における送信電極は、感知装置の長軸を中心に対称的に形成された第1電極及び第2電極を含んで構成されている。 In FIG. 2, (a) shows the structure of the transmission electrode of the sensing device used in FIG. 1, and the transmission electrode includes a first electrode and a second electrode that surround both ends of the sensing device, respectively. Yes. The transmission electrode in (b) includes a first electrode that surrounds one end of the sensing device and a second electrode that covers the other end of the sensing device in a strip shape. The transmission electrode in (c) includes a first electrode and a second electrode that respectively cover both ends of the sensing device in a band shape. In addition, the transmission electrode in (d) includes a first electrode and a second electrode that are formed symmetrically about the major axis of the sensing device.
送信電極は、人体の内部に露出しているため、消化液などの反応性物質に耐えることができるように、耐腐食性に優れ、かつ、人体に無害な金属でなければならない。本発明の一実施形態においては、耐腐食性に優れ人体に無害な金属として、SUS316L又は金を使用した。また、感知装置の表面に形成された送信電極を電気的に絶縁させるために、感知装置の表面を、人体に無害で、かつ、電気を通さない絶縁体で構成しなければならない。人体に無害な絶縁体としては、プラスチック系のピーク(peek)、ポリエチレン又はポリプロピレンを使用することができる。また、人体に対する無害性をさらに向上させるために、ピーク、ポリエチレン又はポリプロピレンで形成した感知装置の表面にパリレンをコーティングすることもできる。 Since the transmitting electrode is exposed to the inside of the human body, it must be a metal that has excellent corrosion resistance and is harmless to the human body so that it can withstand reactive substances such as digestive fluid. In one embodiment of the present invention, SUS316L or gold is used as a metal that is excellent in corrosion resistance and harmless to the human body. Further, in order to electrically insulate the transmission electrode formed on the surface of the sensing device, the surface of the sensing device must be made of an insulator that is harmless to the human body and does not conduct electricity. As an insulator that is harmless to the human body, a plastic-based peak, polyethylene, or polypropylene can be used. In order to further improve the harmlessness to the human body, parylene can be coated on the surface of the sensing device made of peak, polyethylene or polypropylene.
図3は、本発明に係る人体を通じたデータ通信システムに使用される、感知装置の一実施形態であるカプセル型内視鏡の内部構造を示した断面図である。図3に示したカプセル型内視鏡は、直径10mm、長さ20mm程度のサイズである。カプセル型内視鏡の外形を形成するハウジングの一端はドーム状の受光窓17で形成され、他端は矩形の収納体18で形成されている。従って、全体的に弾丸形状をなしている。
FIG. 3 is a cross-sectional view showing the internal structure of a capsule endoscope as an embodiment of a sensing device used in a data communication system through a human body according to the present invention. The capsule endoscope shown in FIG. 3 has a diameter of about 10 mm and a length of about 20 mm. One end of the housing forming the outer shape of the capsule endoscope is formed by a dome-shaped
カプセル型内視鏡の受光窓17は、光が通過する部分であり、人体に無害で光を通過させる材質で形成される。収納体18は、後述するいくつかの素子を含んで形成される部分であり、人体に無害な絶縁体で構成される。受光窓17と収納体18とは、シールされており、例えば、消化器官の粘液などがカプセル型内視鏡の内部に浸透したり、又はカプセル型内視鏡内の物質が人体の内部に漏れないようになっている。
The
図3に示したように、カプセル型内視鏡は、受光窓17と収納体18とを含で構成されるハウジングの外形を有している。収納体18の内部には、照明素子12、レンズ13、CMOSイメージセンサ14、バッテリー15、及び収納体18の表面に電気的に絶縁されて形成された送信電極11を含んでいる。
As shown in FIG. 3, the capsule endoscope has an outer shape of a housing including a
受光窓17の後方にレンズ13が配置され、レンズ13の後方に各種回路が集積されているCMOSイメージセンサ14が配置されている。レンズ13とCMOSイメージセンサ14間の距離は、受光窓17を通じて入射した光がCMOSイメージセンサ14の表面に集束されるように調整される。レンズ13とCMOSイメージセンサ14との間には、ドーナツ状の配列で複数の照明素子12が配置されている。本発明の一実施形態においては、照明素子12として4つのLEDを使用した。照明素子12から照射された光が受光窓17を円滑に通過して対象物を照らすことができるように、受光窓17の内面及び外面には、非反射コーティングが施されている。CMOSイメージセンサ14の後方には、電源を供給するバッテリー15が配置されている。本発明の一実施形態においては、バッテリー15として、放電電圧が平坦で人体に対する害の少ない酸化銀電池を使用した。
A
カプセル型内視鏡の内部動作を以下に簡単に説明する。照明素子12が光を照射している間、CMOSイメージセンサ14が、レンズ13を通して対象物の映像を捕捉(キャプチャ)し、該捕捉した映像信号を内部の各種回路により加工した後、該加工処理した信号を2つの出力線16にそれぞれ接続された送信電極に印加する。これによって、前述したように、人体を導体として人体の外部の受信電極が信号を感知できるようになる。
The internal operation of the capsule endoscope will be briefly described below. While the
図4は、カプセル型内視鏡の動作原理をより詳しく説明するための前記CMOSイメージセンサ14の回路構成図を示したものである。 FIG. 4 is a circuit configuration diagram of the CMOS image sensor 14 for explaining the operation principle of the capsule endoscope in more detail.
図4に示したように、CMOSイメージセンサ14は、映像信号を捕捉して保存するピクセルアレイ100と、各ピクセルの信号を順次引き出すリード回路110と、リード回路110の出力信号を符号化する符号化回路120と、符号化回路120で符号化された信号を2つの出力線に伝達するスイッチング回路130と、人体に有害な大きさの電流が流れないように電流値を調整する電流制限回路140と、信号処理及び照明素子12の動作を制御する制御回路150と、動作周波数を決定する発振回路160と、を含んで構成される。
As shown in FIG. 4, the CMOS image sensor 14 includes a
本発明の一実施形態において、ピクセルアレイ100は、ピクセルの数が320×240であり、高解像度の映像信号を捕捉及び保存することができる。この保存された映像信号は、リード回路110によって1秒当たり1フレームずつ順次処理される。従って、コスト及びサイズの面で不利なメモリを不要とすることができる。また、制御回路150は、ピクセルアレイ100に入射した光の明るさから人体の内部の明暗度を判定して、照明素子12を5〜200msecの間で可変させて、その動作を制御する。その間の映像信号はピクセルアレイ100で捕捉されている。これにより、それぞれの映像フレームが瞬間的に捕捉され、かつ、明るさが向上する。また、符号化方式としては、簡単でかつ耐ノイズ特性を有するPSK方式を採用した。
In one embodiment of the present invention, the
スイッチング回路130は、符号化回路120から送信された信号が「1」であると、第1出力線16aに「+」電圧を印加して第2出力線16bを接地し、符号化回路120から送信された信号が「0」であると、第1出力線16aを接地して第2出力線16bに「+」電圧を印加する。このように、信号を電圧の大きさではなく、電圧の極性で伝達するようにしたことにより、さらに耐ノイズ性を強化することができる。
When the signal transmitted from the
電流制限回路140は、人体に5mA以上の電流が流れないようにする役割を果たす。本発明の一実施形態においては、スイッチング回路130の2つの出力線16に、それぞれ直列に抵抗を接続して電流制限回路140を実現した。即ち、電源電圧が3Vの場合、2つの出力線にそれぞれ直列に300Ωの抵抗を接続して電流制限回路を構成すると、人体への抵抗が非常に小さいため、送信電極が短絡しても人体に流れる電流は5mAを超過しない。さらに、各抵抗にキャパシタを並列に接続して、人体に送信される信号の高周波成分を除去し、人体との電気的な整合を図ることにより、一層優れた信号送信が行われるようにした。
The current limiting
電流制限回路140を経た信号は、最終的に2つの送信電極11に印加され、人体を通して、その外部に送信される。既存の電波通信方式においては、数百MHzの高周波信号が必要であったが、本発明においては、10MHzの低周波信号によってもカプセル型内視鏡が捕捉した映像信号を人体の外部に送信することができる。
The signal that has passed through the current limiting
以上説明したように、本発明は、アンテナを通しての高周波の無線方式ではなく、人体を導体として低周波及び低電流で通信するため、人体に無害でかつ消費電力を小さくすることができ、人体における信号減衰を少なくし、人体の外部の電波干渉を受けないだけでなく、電圧の極性で信号を送信するため、一層ノイズに強く、受信感度が格段に優れるという効果がある。 As described above, the present invention is not a high-frequency radio system through an antenna, but communicates with a human body as a conductor at a low frequency and a low current, so that it is harmless to the human body and can reduce power consumption. In addition to reducing signal attenuation and not receiving radio wave interference outside the human body, the signal is transmitted with the polarity of the voltage, so that it is more resistant to noise and has an excellent reception sensitivity.
また、本発明に係る感知装置は、無線送信器及びアンテナを必要としないだけでなく、映像信号を時間経過によって順次処理するため、別途のメモリを必要とせず、サイズが小さくて安価なカプセル型内視鏡を提供し得るという効果がある。 In addition, the sensing device according to the present invention does not require a wireless transmitter and an antenna, but also sequentially processes video signals over time, so that a separate memory is not required, and the capsule type is small and inexpensive. There is an effect that an endoscope can be provided.
Claims (42)
前記感知装置の表面に設置された送信電極間に電位差を発生させる段階と、
相対的に高い電位を有する送信電極から、電流を、人体の内部に供給して、人体の表面通じて、人体の内部に戻る電流を流し、相対的に低い電位を有する送信電極にシンクさせる段階と、
前記人体の表面を流れる電流により、人体の表面に装着された受信電極間に電圧を誘起する段階と、
を含むことを特徴とする人体を通じたデータ通信方法。 In a data communication method through a human body for transmitting a signal to the outside of the human body from a sensing device thrown inside the human body,
Generating a potential difference between transmission electrodes installed on the surface of the sensing device;
Supplying a current from a transmitting electrode having a relatively high potential to the inside of the human body, passing a current returning to the inside of the human body through the surface of the human body, and sinking the transmitting electrode having a relatively low potential to the sinking electrode When,
Inducing a voltage between the receiving electrodes attached to the surface of the human body by a current flowing on the surface of the human body;
A data communication method through the human body, characterized by comprising:
人体の表面に装着されて前記電位差により発生した電流を人体を通して受信する受信器と、
を含むことを特徴とする人体を通じたデータ通信システム。 A sensing device including a transmission electrode that is inserted into a human body to generate a potential difference;
A receiver that is mounted on the surface of the human body and receives the current generated by the potential difference through the human body;
A data communication system through the human body, characterized by comprising:
人体の内部を照射する照明素子と、
人体の内部から入射した光を集束するレンズと、
前記レンズにより集束された光から電気信号を生成するCMOSイメージセンサと、
前記照明素子、前記レンズ及び前記CMOSイメージセンサを収容するハウジングと、
前記ハウジングの表面に設置されて前記電気信号が印加される送信電極と、
を含むことを特徴とするカプセル型内視鏡。 In a capsule endoscope thrown into the human body,
A lighting element that illuminates the interior of the human body;
A lens that focuses light incident from inside the human body;
A CMOS image sensor that generates an electrical signal from the light focused by the lens;
A housing for housing the illumination element, the lens and the CMOS image sensor;
A transmitting electrode installed on the surface of the housing and applied with the electrical signal;
A capsule endoscope comprising:
映像信号を電気信号に変換し、該電気信号を保存するピクセルアレイと、
前記ピクセルアレイの電気信号を順次引き出すリード回路と、
前記リード回路の出力信号を符号化する符号化回路と、
前記符号化された信号に従って出力線の極性を変更するスイッチング回路と、
所定値以上の電流の流れを制限する電流制限回路と、
前記照明素子の動作及び前記CMOSイメージセンサの動作を制御する制御回路と、
パルスを発生する発振回路と、
を含むことを特徴とする請求項15に記載のカプセル型内視鏡。 The CMOS image sensor is
A pixel array for converting a video signal into an electrical signal and storing the electrical signal;
A lead circuit for sequentially extracting electrical signals of the pixel array;
An encoding circuit for encoding the output signal of the read circuit;
A switching circuit that changes the polarity of the output line according to the encoded signal;
A current limiting circuit that limits the flow of current above a predetermined value;
A control circuit for controlling the operation of the illumination element and the operation of the CMOS image sensor;
An oscillation circuit for generating a pulse;
The capsule endoscope according to claim 15, comprising:
前記カプセル型内視鏡の表面に設置された送信電極間に電位差を発生する段階と、
相対的に高い電位を有する送信電極から、電流を、人体の内部へ供給して、人体の表面を流した後、再び人体の内部に流れ込む電流を、相対的に低い電位を有する送信電極にシンクする段階と、
前記人体の表面を流れる電流により、人体の表面に装着された受信電極間に電圧を誘起する段階と、
を含むことを特徴とする人体を通じたデータ通信方法。 In a data communication method through a human body for transmitting a signal from the capsule endoscope thrown into the human body to the outside of the human body,
Generating a potential difference between transmission electrodes installed on the surface of the capsule endoscope;
After a current is supplied from the transmitting electrode having a relatively high potential to the inside of the human body and flows through the surface of the human body, the current flowing into the human body again is sinked to the transmitting electrode having a relatively low potential. And the stage of
Inducing a voltage between the receiving electrodes attached to the surface of the human body by a current flowing on the surface of the human body;
A data communication method through the human body, characterized by comprising:
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| PCT/KR2003/002937 WO2004068748A1 (en) | 2003-01-25 | 2003-12-31 | Method and system for data communication in human body and sensor therefor |
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Also Published As
| Publication number | Publication date |
|---|---|
| CN1742448A (en) | 2006-03-01 |
| EP1593214B1 (en) | 2011-08-31 |
| AU2003288791A1 (en) | 2004-08-23 |
| JP4166220B2 (en) | 2008-10-15 |
| KR20040068425A (en) | 2004-07-31 |
| EP1593214A4 (en) | 2006-09-06 |
| US8160672B2 (en) | 2012-04-17 |
| ATE522988T1 (en) | 2011-09-15 |
| WO2004068748A1 (en) | 2004-08-12 |
| EP1593214A1 (en) | 2005-11-09 |
| US20060243288A1 (en) | 2006-11-02 |
| KR100873683B1 (en) | 2008-12-12 |
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