JP2007308379A - Emulsion type external preparation for skin - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a means which contains a sphingoglycolipid and/or a phytosterolglycoside, strengthens the interfaces of microemulsion particles, and prevents the uniting of the microemulsion under high temperature storage conditions. <P>SOLUTION: This external preparation for the skins is characterized by comprising (1) a sphingoglycolipid and/or a phytosterolglycoside, and (2) L-carnitine and/or its salt. The dosage form of the external preparation for the skins is preferably a water-in-oil type emulsion form. It is preferable to contain the sphingoglycolipid and/or the phytosterolglycoside in the form of the microemulsion. The microemulsion is preferable to be a microemulsion formed from a phospholipid. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to an external preparation for skin, and more particularly to an external preparation for skin suitable for cosmetics.

  Sphingosine is one of the components of the skin and is said to play an important role in the physiological functions of the skin, and the glycolipid that is a glycoside also has physiological activity. Glycosphingolipids are also contained in plants such as rice and wheat germ. In such plants, phytosterol glycosides coexist, and the phytosterol glycosides are also present in the skin. On the other hand, it has important effects such as improvement of the barrier function and adjustment of the cell cycle (cell cycle) of stratum corneum cells. (For example, see Patent Document 1 and Patent Document 2) These sphingosine glycosides or phytosterol glycosides are preferable components for the skin, but on the other hand, they have the property of being hardly soluble in water and oily components. Therefore, the preparation of the preparation is accompanied with great difficulty. (For example, refer to Patent Document 3) As a method of covering this defect, after blending these components that are hardly soluble in water and oil into microemulsions using phospholipids and polyhydric alcohols, they are blended into an emulsifying system. Technology has been developed to increase the effectiveness. (For example, refer to Patent Document 4) In this technique, in the formulation such as solubilizing lotion, the microemulsion particles are extreme such as storage under freezing conditions or high temperature conditions of 60 ° C. or higher. However, in the emulsification system, particularly, the water-in-oil emulsification system, the microemulsion particles coalesce under the above extreme conditions, particularly at high temperatures of 50 to 70 ° C. There was a case where the stability was impaired. Such coalescence may induce crystallization of the sparingly soluble components, glycosphingolipids and phytosterol glycosides, and may affect stability. That is, it has been desired to develop a means for strengthening the interface of microemulsion particles and preventing coalescence of the microemulsion under high temperature storage conditions.

  On the other hand, L-carnitine and / or a salt thereof is known as an active ingredient for cosmetics having an anti-inflammatory action and the like, and a technique for inclusion in cosmetics is already known (for example, Patent Document 5, It is not known to contain 1) glycosphingolipid and / or phytosterol glycoside, and 2) L-carnitine and / or a salt thereof. It is also not known at all that coalescence of emulsion particles containing glycosphingolipids is suppressed under high temperature storage conditions.

JP-A-5-85924 JP 2004-256471 A JP 2002-114631 A JP-A-9-301820 JP 2005-53835 A JP 2004-339144 A JP 2004-242509 A

  The present invention has been made under such circumstances, and enhances the interface of microemulsion particles containing glycosphingolipids and / or phytosterol glycosides, and unites the microemulsions under high temperature storage conditions. It is an object to provide means for preventing the problem.

In view of such circumstances, the present inventors strengthen the interface of microemulsion particles containing glycosphingolipids and / or phytosterol glycosides, and prevent coalescence of microemulsions under high temperature storage conditions. As a result of diligent research efforts to find a means, such a combination of 1) glycosphingolipid and / or phytosterol glycoside and 2) L-carnitine and / or a salt thereof can be achieved. I found out that I could suppress it and completed the invention. That is, the present invention is as follows.
(1) An external preparation for skin, comprising 1) glycosphingolipid and / or phytosterol glycoside, and 2) L-carnitine and / or a salt thereof.
(2) The skin external preparation is in a water-in-oil emulsifier form, and the sphingoglycolipid and / or phytosterol glycoside is contained in the form of a microemulsion. The skin external preparation as described.
(3) The external preparation for skin according to (2), wherein the microemulsion is a microemulsion formed of phospholipid.
(4) The external preparation for skin according to any one of (1) to (3), wherein the L-carnitine and / or a salt thereof is L-carnitine chloride.
(5) The external preparation for skin according to any one of (1) to (4), which is in the form of a water-in-oil emulsifier.

  ADVANTAGE OF THE INVENTION According to this invention, the means of strengthening the interface of microemulsion particle | grains containing a sphingoglycolipid and / or a phytosterol glycoside, and preventing the coalescence of the microemulsion under high temperature storage conditions can be provided.

(1) Glycosphingolipid and / or phytosterol glycoside which is an essential component of the external preparation for skin of the present invention The skin external preparation of the present invention contains sphingoglycolipid and / or phytosterol glycoside as an essential component And The glycosphingolipid has a structure represented by the following general formulas (1) to (2), and the sugar residue in the formula is preferably a glucose residue, such as plants such as rice bran, bran (wheat germ), It is present in cocoons, straw, soybeans, cocoons, corn, etc., and these plant materials are extracted with an organic solvent such as hexane, petroleum ether, chloroform after removing fats and sugars by pretreatment according to known methods. Further, it can be obtained by purification by a purification means such as column chromatography. Phytosterol is a general term for plant sterols, and plant sterols include stigmasterol, campesterol, sitosterol, and the like, and these are collectively called phytosterols. As phytosterol, a sterol fraction containing a plurality of phytosterols can be taken out from a plant such as wheat germ and used. Such glucosides of phytosterols, specifically phytosterol glucosides, are also present in plants and are often present in fractions similar to glycosphingolipids. It is similar. In many cases, the glycosphingolipid is mixed during fractionation and purification, and such a mixture extract of glycosphingolipid and phytosterol glycoside can be used in the external preparation for skin of the present invention. In the external preparation for skin of the present invention, such a glycosphingolipid and / or phytosterol glycoside has low solubility in both an oily component and an aqueous component. It is preferable to form and contain an emulsion. Phospholipids such as phosphatidylinositol, phosphatidylglycerol, phosphatidylethanolamine, lecithin, or their lyso form are 0.3 to 3 times the weight of plant-derived glycosphingolipid and phytosterol glycoside, and monohydric alcohol such as ethanol is 5 -20 times weight, 1,3-butanediol, dipropylene glycol, isoprene glycol, 1,2-pentanediol, 1,2-hexanediol and other dihydric alcohols are used 5-30 times weight, sphingoglycolipid and phytosterol It is preferable to dissolve the glycoside in an aqueous system to form a microemulsion and to contain it. For such microemulsions, there are cosmetic raw materials processed in such a form, and such cosmetic raw materials can be purchased and used. As such a commercially available raw material for cosmetics, “FR-1” sold by Okayasu Shoten Co., Ltd. exists. This comprises 1% by weight of a mixture of glycosphingolipid and phytosterol glycoside in a weight ratio of 80:20 to 90:10, 0.5% by weight soybean lecithin, 10% by weight 1,3-butanediol, , 8% by mass ethanol dispersed in the remaining water as a microemulsion. Okayasu Shoten Co., Ltd. also sells “Phytosteside” which is a mixture of phytosterol glycoside and glycosphingolipid at a mass ratio of 80:20 to 90:10. These components may be used to form a microemulsion with phospholipid, 1,3-butanediol, ethanol and water. In the external preparation for skin of the present invention, such a component has an action of reinforcing the structure of the emulsified particles that are the discontinuous phase of the water-in-oil emulsification system and preventing the aqueous phase from protruding from the water-in-oil emulsified structure. In order to exert such an effect, the total amount of the glycosphingolipid and / or phytosterol glycoside is preferably 0.0005 to 0.1% by mass, and 0.0001 to 0.01% by mass is contained. It is more preferable. This is because if the amount is too small, the above-mentioned effect may not be achieved, and if it is too large, the crystal may be precipitated without being included in the system.

一般式（１）
（但し式中Ｒ１は糖残基を表し、Ｒ２破綻素数１２〜２４のアルキル基を表す。）

General formula (1)
(In the formula, R1 represents a sugar residue, and R2 represents an alkyl group having 12 to 24 disruptive elements.)

一般式（２）
（但し式中Ｒ１は糖残基を表し、Ｒ２破綻素数１２〜２４のアルキル基を表す。）

General formula (2)
(In the formula, R1 represents a sugar residue, and R2 represents an alkyl group having 12 to 24 disruptive elements.)

(2) L-carnitine which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing L-carnitine and / or a salt thereof as an essential component. L-carnitine has the structure shown below and has already been used as a raw material for cosmetics. Such a commercial product can be purchased and used. Moreover, since it is marketed also as a reagent, the acquisition is easy. In the present invention, such L-carnitine can be used as it is, or it can be contained in the form of a salt without any acid or the like. In storage, the salt state is more stable, so it is preferable to use a salt. As the salt, any salt that is usually used in an external preparation for skin can be used without particular limitation. For example, salts such as sulfates, hydrochlorides, nitrates, phosphates, carbonates, etc. Preferred examples include organic acid salts such as acid salts, tartrate salts, oxalate salts, lactate salts and acetate salts, and acidic amino acid salts such as glutamate salts and aspartates. Such components have the effect of stabilizing the structure of the organically modified clay mineral and improving the ability to include oil-soluble active ingredients. In order to exert such an action, L-carnitine and / or a salt thereof may be contained in an amount of 0.1 to 10% by mass with respect to the total amount of the external preparation for skin, in terms of L-carnitine equivalent. Preferably, the content is 0.5 to 5% by mass. This is because if the amount is too small, the above effect may not be achieved, and if the amount is too large, the emulsification system may be damaged.

Ｌ−カルニチン

L-carnitine

(3) The skin external preparation of this invention The skin external preparation of this invention contains the said essential component, It is characterized by the above-mentioned. In the external preparation for skin of the present invention, a water-in-oil emulsifier form is preferred. This is because the organically modified clay mineral sphingoglycolipid and / or phytosterol glycoside, which are essential components, improve the transferability to the skin in the composition of the water-in-oil emulsifier form. In particular, the water-in-oil emulsifier form having a high internal phase is preferable because it does not impair this effect and has good usability such as a feeling of use. Here, the high internal phase water-in-oil emulsifier form means that the sum of the mass of water, the mass of ethanol, and the mass of polyhydric alcohol exceeds 50 mass%. In order to take such a high internal phase water-in-oil emulsifier form, it is preferable to emulsify using an organically modified clay mineral.

  Here, organic modification means that a part or all of the properties of an organic compound is made into a clay mineral by causing a part of the organic compound to form a strong or loose bond via a covalent bond or an ionic bond. This means that it is imparted to minerals. Examples of such modifications include a method of binding a quaternary amine group and an anion portion of a clay mineral, and a method of binding a carboxyl group and a cation portion of a clay mineral. A method of bonding the group and the anion portion of the clay mineral is particularly preferable.

  Although it does not necessarily limit as a compound which has a quaternary amino group which modifies a clay mineral, The compound called quaternium is illustrated. Quotanium is a low molecular weight substituted quaternary ammonium salt, and is preferably a cosmetic raw material registered in International Standard Cosmetic Ingredients (INCI). Furthermore, the compound having a quaternary amino group that modifies the clay mineral is preferably a quaternium compound contained in a conventional external skin preparation among quaternium compounds. Preferred examples of the quaternium compound used in conventional external preparations for skin include stearyl trimethyl ammonium chloride and dimethyl distearyl ammonium chloride. Stearyl trimethyl ammonium chloride, dimethyl distearyl ammonium chloride and the like are preferable because they can form a stable water-in-oil emulsion structure together with clay minerals.

  On the other hand, as a clay mineral (unmodified clay mineral) modified with a compound having a quaternary amino group, any clay mineral contained in a conventional skin external preparation can be used without any particular limitation. Preferred clay minerals contained in conventional skin external preparations include smectite-type hectorite, bentonite and montmorillonite; kaolinite; illite; marine clay mineral (sea mud); desert rose clay mineral; Among these, bentonite, hectorite, montmorillonite or kaolinite which can stabilize the water-in-oil emulsion structure is preferably exemplified.

An example of a method for producing a clay mineral modified with a compound having a quaternary amino group contained in the external preparation for skin of the present invention will be described below.
The unmodified clay mineral is dispersed in a dispersion medium. The dispersant is preferably an aqueous solvent, and may be water. A compound having a quaternary amino group is further added to the dispersion containing the dispersed unmodified clay mineral and stirred well. The compound having a quaternary amino group may be added after being dissolved in water. The amount of the compound having a quaternary amino group to be added is preferably 0.1 to 20% by mass, and more preferably 0.5 to 15% by mass with respect to the amount of the dispersed unmodified clay mineral. This is because by taking such a configuration, a preferable feeling of use is exhibited in the emulsification system. After stirring, the dispersoid is filtered, dehydrated and dried to obtain the modified clay mineral in the present invention. Or the modified clay mineral in this invention can also be obtained by removing a dispersing agent by concentrating under reduced pressure without filtering a dispersoid, and making it dry. The obtained modified clay mineral is preferably pulverized to a desired size (preferably having a particle size of 1 to 1000 μm) and contained in the skin external preparation of the present invention.

  The modified clay mineral in the present invention can be prepared and used as described above, but a commercially available one can also be used. Some modified clay minerals on the market are used as external preparations for skin such as cosmetics. Preferable examples of commercially available modified clay minerals include dimethyl distearyl ammonium modified hectorite sold under the name “Benton 38V” by Elementis.

  In the skin external preparation of this invention, this component is contained preferably 0.5-10 mass%, More preferably, 1-5 mass% is contained. Such an ingredient acts as an emulsifier in the above-mentioned content range to form a high internal phase water-in-oil emulsifier form.

  Further, as described above, when taking the water-in-oil emulsifier form, it is preferable to contain silicone in order to compensate for the drawbacks of the feeling of use and finish of the water-in-oil emulsifier form. Is preferably contained in an amount of 10 to 35% by mass, more preferably 20 to 30% by mass. Among these, dimethicone or cyclomethicone is preferably 10 to 30% by mass, and more preferably 15 to 25% by mass. In particular, the mass of cyclomethicone is preferably 50% or more with respect to the sum of the masses of dimethicone and cyclomethicone. Examples of silicones other than dimethicone and cyclomethicone are polyether-modified methyl polysiloxanes such as POE-modified methyl polysiloxane, POP-modified methyl polysiloxane, and POP / POE-modified methyl polysiloxane, which may contain such components. This is preferable because the water-in-oil emulsion system can be stabilized. The preferable content of such polyether-modified methylpolysiloxane is more preferably 0.5 to 5% by mass and 1 to 3% by mass.

  The skin external preparation of the present invention can contain a stable oil-soluble active ingredient, particularly, a solid oil-soluble active ingredient in the system by taking the above-described configuration. Preferred examples of such active ingredients include triterpenic acids such as ursolic acid, oleanolic acid, and betulinic acid, derivatives of alkyl esters, alkenyl esters, aromatic esters, and the like of the above-mentioned triterpenic acids, and ceramides. Preferable content of these components is 0.01-1 mass%, respectively, More preferably, it is 0.02-0.2 mass%.

  Of course, the external preparation for skin of the present invention can be applied to dosage forms other than the above-mentioned water-in-oil emulsifier form, while the effects on skin such as phytosterol glycosides and sphingonsin glycolipids do not reach water in oil. Even fully demonstrate.

  In addition to the above-mentioned components, the external preparation for skin of the present invention can contain optional components that are usually used in external preparations for skin. The external preparation for skin of the present invention can contain, in addition to such components, optional components that are usually used in external preparations for skin. Such optional ingredients include, for example, macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hydrogenated coconut oil Oil, wax, oil such as beeswax, canola wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax, liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum , Hydrocarbons such as microcrystalline wax; higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid; cetyl alcohol, stearyl alcohol, isostearyl Higher alcohols such as alcohol, behenyl alcohol, octyldodecanol, myristyl alcohol, cetostearyl alcohol; cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate; dimethylpolysiloxane, methylphenylpoly Linear polysiloxanes such as oxane and diphenylpolysiloxane; cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexanesiloxane; amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, Oil agents such as silicone oils such as modified polysiloxanes such as fluorine-modified polysiloxanes; Anionic surfactants such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, triethanolamine ether of alkyl sulfates; Cationic surfactants such as stearyltrimethylammonium, benzalkonium chloride, laurylamine oxide; imidazoline-based amphoteric surfactants (2-cocoyl-2-imida Zolinium hydroxide-1-carboxyethyloxy disodium salt, etc.), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), and amphoteric surfactants such as acylmethyltaurine; sorbitan fatty acid esters (sorbitan) Monostearate, sorbitan sesquioleate, etc.), glycerin fatty acids (glyceryl monostearate, etc.), propylene glycol fatty acid esters (propylene glycol monostearate, etc.), hardened castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbitol monolaurate, etc.), POE glycerin fatty acid ester Tells (POE-glycerol monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkyl phenyl ethers (POE nonylphenyl) Ethers, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), Nonionic surfactants such as sucrose fatty acid ester and alkyl glucoside; polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, propylene Polyhydric alcohols such as recall, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexanediol, 1,2-hexanediol, 1,2-octanediol; sodium pyrrolidonecarboxylate Moisturizing ingredients such as lactic acid and sodium lactate; powders such as mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, anhydrous silicic acid (silica), aluminum oxide, barium sulfate, etc. whose surface may be treated Body, the surface may be treated, inorganic pigments such as bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide; surface may be treated, mica Pearl agents such as titanium, fish phosphorus foil, bismuth oxychloride; red 202 which may be raked, red Color 228, Red 226, Yellow 4, Blue 404, Yellow 5, Red 505, Red 230, Red 223, Orange 201, Red 213, Yellow 204, Yellow 203, Blue 1 No., green 201, purple 201, red 204, etc .; organic powders such as polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer; para-aminobenzoic acid UV absorbers; anthranils Acid UV absorbers; salicylic acid UV absorbers; cinnamic acid UV absorbers; benzophenone UV absorbers; sugar UV absorbers; 2- (2′-hydroxy-5′-t-octylphenyl) benzo Ultraviolet absorbers such as triazole and 4-methoxy-4′-t-butyldibenzoylmethane; lower grades such as ethanol and isopropanol Alcohols; vitamin A or derivatives thereof, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 or derivatives thereof, vitamin B such as vitamin B12, vitamin B15 or derivatives thereof; α-tocopherol, β- Preferred examples include vitamins such as tocopherol, γ-tocopherol, vitamin E acetate and the like, vitamins D, vitamin H, pantothenic acid, panthetin, pyrroloquinoline quinone, and the like; and antibacterial agents such as phenoxyethanol.

  Among such optional components, particularly preferred are polyhydric alcohols that can stabilize the emulsified state. Particularly preferred are glycerin, diglycerin, 1,3-butanediol, 1,2-pentanediol, 1,2-hexanediol, and isoprene glycol. Such a component may contain only one species or may contain two or more species in combination. The preferred content is 10 to 30% by mass, more preferably 15 to 25% by mass, based on the total amount of the external preparation for skin, as a total amount.

  The external preparation for skin of the present invention can be produced by treating these components according to a conventional method. The external preparation for skin of the present invention is not particularly limited as long as it is externally applied to the skin. For example, basic cosmetics such as lotions, essences, emulsions, creams, packs, foundations, under-makeups, Makeup cosmetics such as control colors, highlights, UV protective cosmetics such as sun care milk and sun care cream, cleaning products such as rinses, shampoos, body shampoos, cosmetics for hair such as hair creams and hair packs, antifungals Skin external medicines, anti-inflammatory skin external medicines, steroid skin external medicines, external skin disinfectants, skin external goods, and the like can be suitably exemplified, among which cosmetics are preferable, and basic cosmetics are particularly preferable. In basic cosmetics, active ingredients can be efficiently transdermally absorbed, and there is a protective effect of the skin barrier function due to occlusive properties, and it is possible to suppress the enhancement of TEWL (transcutaneous water dispersion loss). .

  Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to such examples.

  In accordance with the formulation shown below, a cosmetic preparation in the form of a water-in-oil emulsifier (a form in which a microemulsion exists in water droplets), which is an external preparation for skin of the present invention, was produced. That is, the components of a and b are heated to 80 ° C., and k is kneaded to form a gel. C is added and dissolved therein, and the mixture is gradually added with emulsification and stirring. Upon cooling, a cosmetic 1 in the form of a water-in-oil emulsifier was obtained. In the same manner, Comparative Example 1 in which L-carnitine chloride was replaced with water and Comparative Example 2 in which “FR-1” was replaced with water were also prepared.

<Test Example 1>
Cosmetic 1, Comparative Example 1 and Comparative Example 2 were stored at 20 ° C. for 12 hours after production, and after obtaining the average particle size of the microemulsion in the emulsified particles with an optical microscope at 20 ° C., 50 ° C. The sample was stored for 1 month under the above conditions, stored at 20 ° C. for 12 hours and returned to 20 ° C., and then observed with an optical microscope to determine the average particle size of the microemulsion in the emulsified particles. The results are shown in Table 2. From this, it can be seen that the cosmetic 1 which is an external preparation for skin of the present invention suppresses the coalescence of the emulsified particles at a high temperature and maintains the average particle size of the microemulsion in the emulsified particles. In addition, the average particle diameter of the microemulsion in the emulsified particles was obtained by measuring the diameter of the microemulsion contained in the particles of 10 particles and calculating the average.

  By operating in the same manner as in Example 1, a cosmetic 2 in the form of a water-in-oil emulsifier (a form in which a microemulsion exists in water droplets), which is an external preparation for skin of the present invention, was produced. The average particle size of the microemulsion in water droplets was 0.27 ± 0.10 μm immediately after production, and 0.54 ± 0.26 μm after storage at 50 ° C. for 1 month. A similar effect was confirmed. In addition, as a surfactant for forming a microemulsion, it has become clear from comparison with the cosmetic 1 that phospholipid is preferable.

  The present invention can be applied to an external preparation for skin such as cosmetics.

Claims (5)

A skin external preparation comprising 1) glycosphingolipid and / or phytosterol glycoside, and 2) L-carnitine and / or a salt thereof. The skin according to claim 1, wherein the external preparation for skin is a water-in-oil emulsifier, and the glycosphingolipid and / or phytosterol glycoside is contained in the form of a microemulsion. Topical agent. The skin external preparation according to claim 2, wherein the microemulsion is a microemulsion formed of phospholipid. The external preparation for skin according to any one of claims 1 to 3, wherein the L-carnitine and / or a salt thereof is L-carnitine chloride. The skin external preparation according to any one of claims 1 to 4, which is in the form of a water-in-oil emulsifier.