JP2010025880A - Evaluation method of function of biological cell - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an evaluation method for evaluating the function of biological cells from a non-disease stage to a disease stage when the concentration of K, Na, CRP, and LDH in blood is out of a normal range or fluctuates in the normal range. <P>SOLUTION: The first concentration of at least one or more elements from K, Na, CRP, and LDH in the blood of biological cells is detected. After detecting the first concentration, the second concentration of at least the same one or more elements from K, Na, CRP, and LDH in the blood is detected. The fluctuation from the first concentration to the second concentration is calculated, and the state of the blood from non-disease stage of being earlier than disease stage to disease stage is evaluated from the fluctuation. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a method for evaluating the function of a living cell, which grasps the stage from a disease-free stage to a pathological stage of blood in the living cell.

Conventionally, the evaluation of K and Na concentrations in serum is called hypokemia, hyperkemia, hyponatremia and hypernatremia when it is far from the normal range. The treatment for was instructed. CRP and LDH values were similarly evaluated and treatment was indicated.
In addition, for example, Patent Document 1 proposes a “measurement method based on impedance for hemodynamic parameters”, and the sodium concentration in serum is mathematically estimated and obtained as a result. Is sent to the central station, preferably by telephone or email, where the results are further processed and evaluated, after which all necessary measurement and treatment changes are communicated to the patient from a remote location. ing.
JP-T-2006-501892

However, even if the serum concentration of K, Na, CRP, LDH, etc., fluctuates within the normal range, at the actual cell level, there are changes based on biochemical reactions due to some external and internal factors. This change may occur, and this change is a sign of a significant departure from the normal range and is an “undisease” condition in oriental medicine.
Therefore, even if changes in the concentration of K, Na, CRP, LDH, etc. in the serum are fluctuations within the normal range, they are very important indicators for grasping the “non-disease” state.
Therefore, the present invention provides functions of living cells from the non-disease stage to the pathological stage even when the concentration of K, Na, CRP, and LDH in the blood is out of the normal range or even when the normal range changes. It aims at providing the evaluation method of the function of the biological cell to evaluate.

The method for evaluating the function of a biological cell of the present invention for solving the above-described problem is to detect a first concentration of any one or more elements of K, Na, CRP, and LDH in the blood of the biological cell,
After detecting the first concentration, detecting a second concentration in the same element of any one or more of the K, Na, CRP, LDH in the blood;
Calculating the increase or decrease from the first concentration to the second concentration;
The state from the disease-free stage before the pathological stage of the blood to the pathological stage is evaluated from the increase / decrease.

Furthermore, the biological cell function evaluation method of the present invention is the biological cell function evaluation method, wherein the second concentration is less than the first concentration of K, and the first concentration of Na. When the second concentration is further decreased, it is evaluated that the state of the blood has deteriorated.
Furthermore, the biological cell function evaluation method of the present invention is the biological cell function evaluation method, wherein the second concentration increases from the first concentration of K, and the first concentration of Na. When the second concentration is further increased, it is evaluated that the state of the blood is improved.
Furthermore, the biological cell function evaluation method of the present invention is the biological cell function evaluation method, wherein the second concentration increases from the first concentration of K, and the first concentration of Na. When the second concentration is further decreased, it is evaluated that the state of the blood has deteriorated.
Furthermore, the biological cell function evaluation method of the present invention is the biological cell function evaluation method, wherein the second concentration is less than the first concentration of K, and the first concentration of Na. When the second concentration is further increased, it is evaluated that the state of the blood is improved.

When living organisms perform life activities, the mineral balance inside and outside the cells is adjusted at the living cell level in order to maintain the functions of living cells. In particular, the concentration adjustment of K and Na is strictly performed, and the adjustment by an Na-K pump that performs active transport using ATP as energy is important. When an inflammatory reaction occurs due to an infection or the like, glucose is used as a raw material, and the ATP production from the glycolysis system to the citric acid circuit and further the electron transfer system does not proceed normally, and the function of the Na-K cell membrane pump becomes insufficient due to ATP deficiency. descend. When the function of the Na-K cell membrane pump decreases, changes occur in the concentration of K and Na inside and outside the cell.

Therefore, blood tests are performed twice during the clinical course, and changes in the function of the Na-K cell membrane pump can be confirmed by the increase and decrease in K and Na for the current time and the previous time.
Furthermore, after the disorder of energy metabolism for producing ATP in cells, the endothelial cells of peripheral blood vessels are stimulated by cytokines and the like that increase with inflammation, blood vessel permeability is increased, and the circulating blood volume is once reduced. From this point, peripheral circulatory failure occurs.
In the kidney that catches this change, the renin-angiotensin-aldosterone system operates to reabsorb Na and water in the urine while excreting K. As a result, the K and Na concentrations in the blood are reduced. When this process is evaluated by two blood tests, in the case of the right shoulder type in which the second concentration is decreased from the first concentration of K and the second concentration is decreased from the first concentration of Na, Assess that blood condition has deteriorated.

  When the blood condition is improved by treatment, the function of the renin-angiotensin-aldosterone system decreases, the reabsorption of Na and water in urine decreases, and the excretion of K also decreases. As a result, the concentration of K and Na increased, and the concentration of the blood test for two times increased from the first concentration of K to the second concentration, and increased from the first concentration of Na to the second concentration. In the case of the shoulder-up type, it is evaluated that the blood condition has improved.

When a problem occurs in a glycolysis system that generates energy necessary for life support, a citric acid circuit, or an electron transfer system, the amount of ATP changes rapidly, which affects the cell membrane pump function of Na-K using ATP.
This change is a change in the concentration of K and Na. The concentration change twice before and after increases the second concentration from the first concentration of K and decreases the second concentration from the first concentration of Na. In the case of the spread type, the blood condition is evaluated as worsened.
Furthermore, in the case of the end atrophy type in which the second concentration is decreased from the first concentration of K and the second concentration is increased from the first concentration of Na, it is evaluated that the blood state has been improved.

At that time, the reaction change of the glycolysis is related to the activity change of the enzyme LDH which converts pyruvate to lactic acid. The LDH activity change may be shifted from the change in the concentration of K and Na due to the change in the Na-K cell membrane pump, and the change in the concentration of K and Na and the change in the LDH activity value should be evaluated in combination. Can detect and evaluate the deviation of the blood condition from worsening or improving time.
That is, LDH activity may change before the Na-K cell membrane pump is affected, and the combination of K and Na concentrations and changes in LDH activity can detect changes in the state of blood more precisely. Can be evaluated.
Changes such as infectious diseases that place a heavy burden on the living body not only affect the energy metabolism system but also affect the circulatory dynamics. Cytokines generated with inflammation such as infections stimulate vascular endothelial cells to increase vascular permeability. The change affects the concentration of K and Na through the renin-angiotensin-aldosterone system, and the two concentration changes before and after the second concentration decrease from the first concentration of K. When the second concentration is lower than the concentration of the blood, it is evaluated that the blood state has deteriorated.
Furthermore, when the second concentration is higher than the first concentration of K and the second concentration is higher than the first concentration of Na, it is evaluated that the blood state has improved.

  CRP, which is an index of inflammation such as infectious diseases, is useful for confirming the effects of antibiotics in infectious diseases. When the antibiotic is successful, CRP decreases, resulting in a decrease in inflammatory cytokines, improvement of peripheral circulatory failure, recovery of cellular metabolic functions, and improvement of the Na-K plasma membrane pump. CRP changes are important as an indicator of direct inflammation, and are related to improvement in inflammation, K and Na concentrations, and changes in LDH activity.

  According to the present invention, when the concentrations of K, Na, CRP, and LDH in the blood are out of the normal range, or even when the normal range changes, the function of living cells from the non-disease stage to the pathological stage is improved. evaluate.

Embodiments of the present invention will be described below with reference to the accompanying drawings.
In the method for evaluating the function of a living cell according to the first type of the present invention, the second concentration is decreased from the first concentration of K, and the second concentration is decreased from the first concentration of Na. If the concentration of is decreased, it is evaluated that the state of the blood has deteriorated.
Further, in the method for evaluating the function of a living cell according to the second type of the present invention, the second concentration is increased from the first concentration of K, and the Na concentration is higher than the first concentration of Na. If the second concentration increases, it is assessed that the condition of the blood has improved.
Furthermore, in the method for evaluating the function of a living cell according to the third type of the present invention, the second concentration is increased from the first concentration of K, and the Na concentration is higher than the first concentration of Na. If the second concentration decreases, it is evaluated that the state of the blood has deteriorated.
Furthermore, in the method for evaluating the function of a living cell according to the fourth type of the present invention, the second concentration is decreased from the first concentration of K, and the Na concentration is more than the first concentration. If the second concentration increases, it is assessed that the condition of the blood has improved.
In the embodiment of the present invention, as shown in FIG. 1, the values of K, Na, CRP, and LDH are classified into 16 patterns in combination, and the severity of severity is further evaluated in 6 stages.
Here, XX is a markedly improved evaluation, ◯ is an improved evaluation, △ is a slightly improved evaluation, X is a slightly deteriorated evaluation, XX is a deteriorated evaluation, and XXX is Shows a markedly worsened evaluation.
In addition, it is not limited to 16 patterns and 6 steps of the present Example of FIG.

Case 1 Evaluation of pneumonia treatment according to an embodiment of the present invention
85-year-old woman (1) On February 25, 2008, she had a fever, so a blood test was performed. When this example is evaluated from a blood test from February 18 to February 25, potassium K is decreased by -0.15, sodium Na is also decreased by -1.8, and the shoulder-down type is obtained. (First type embodiment).
This is thought to be because the amount of water in the blood was increased because the renin-angiotensin-aldosterone system was activated after vascular endothelial cells were damaged and edema, resulting in a decrease in K and Na concentrations. In addition, CRP is increased by +5.97 and infection is getting stronger. It is considered that LDH decreases by -37, the glycolysis system of energy metabolism operates, and the reaction to the citric acid cycle is progressing. The overall evaluation according to this example is XX, and treatment is performed with attention to appropriate antibiotic administration. The overall evaluation according to this example is xx, and the degree of deterioration is high. Therefore, an antibiotic and globulin were used in combination, and a short-term effect was expected.
(2) When the evaluation according to the present example is performed from the result of the blood test on February 27, K decreases by −0.23, while Na increases by +6.5 to become the end-wilt type. (Fourth type embodiment).
This change restores the Na-K cell membrane pump function. As a result, K is actively transported from the outside of the cell to the inside of the cell, Na is actively transported from the inside of the cell to the outside of the cell, the extracellular K concentration is decreased, and the extracellular Na concentration is increased. . Furthermore, CRP is reduced by -2.93 and the inflammatory response is improved. LDH is similar, the glycolysis system of energy metabolism is activated, and the reaction to the citric acid cycle is progressing. The overall evaluation according to the present example is ◯◯, the cell function is recovered in two days, and the general condition is improved. It can be evaluated that drugs such as antibiotics were effective.
(3) From the results of the blood test on March 3, when the evaluation according to the present example is performed, K increases by +0.45 and Na also increases by +1.1 to become a right-handed type. (Example of the second type)
In this change, peripheral circulation is improved, the amount of water in the blood vessel is moderately adjusted, and the concentrations of K and Na are increased. Furthermore, CRP is reduced by -3.03 and the inflammatory response is improved. LDH is similar, the glycolysis system of energy metabolism is activated, and the reaction to the citric acid cycle is progressing. The overall evaluation according to the present example is ○, and the inflammatory reaction is improving and improving systemically. Antibiotics are administered from February 25 to February 29, and thereafter, the antibiotics are stable even if the antibiotics are discontinued.
(4) From the result of the blood test on March 7, when the evaluation according to this example is performed, K decreases by −0.82 and Na also decreases by −1.4, which is a right-down shoulder type. (First type embodiment)
This change is starting to lead to peripheral circulatory failure. CRP increases by +0.05 and LDH decreases by -33. Some inflammatory substance stimulates vascular endothelial cells due to changes in K and Na to increase vascular permeability, and then the renin-angiotensin-aldosterone system is activated in response to a decrease in the amount of water in the blood. As a result of reabsorption of Na and moisture, while excretion of K, there is a sign that the concentration of K and Na will decrease. The overall evaluation according to this example is XX, and it is expected that the inflammatory reaction will be worsened.
Here, in the renin-angiotensin-aldosterone system, renin from the kidney regulates blood pressure. Renal paraglomerular cells sense changes in renal blood flow, promote renin secretion if decreased, and suppress it if increased. Angiotensin I activated by renin changes to angiotensin II, which has a strong action. Angiotensin II itself has a blood pressure-increasing effect, promotes aldosterone secretion, and increases reabsorption in the kidney, thus suppressing a decrease in blood volume. This is called the renin-angiotensin-aldosterone (RAA) system.
(5) When the evaluation according to the present example is performed from the result of the blood test on March 10, K increases by +0.32, Na decreases by −3.5, and is in a divergent form. (Third type embodiment)
With this change, the cell pump function is reduced. CRP increases by +2.02 and inflammation spreads, and LDH also increases by +61, causing a decrease in energy metabolism. The overall evaluation according to this example is xxx, and the state is in the direction of deterioration. In addition to the administration of appropriate antibiotics, it may be necessary to administer immunoglobulins.
(6) When antibiotics and immunoglobulins were administered from March 10 and the evaluation according to this example was performed based on the blood test results on March 12, K increased by +0.13 and Na also increased by +0.9. Thus, it is an upright shoulder type (second type embodiment).
This change improves peripheral circulation. CRP decreases by -1.29 and inflammation tends to improve, and LDH also decreases by -31, improving energy metabolism. The overall evaluation according to this example is ○, and the state has improved in a short time. Antibiotics and immunoglobulin administration may have led to rapid recovery.
(7) The administration of immunoglobulins was completed for 2 days and antibiotics were administered for 5 days. At the same time, the infusion line considered to be the cause of infection was removed. When the evaluation according to the present example is performed based on the blood test result on March 14, K is increased by +0.63 and Na is decreased by -2.2 to be a divergent type (third type example) ).
With this change, the cell pump function is reduced. CRP increases by +0.22, inflammation tends to relapse, LDH increases by +15, and energy metabolism decreases. The overall evaluation according to this example is xxx, and the state is in the direction of deterioration. In addition, antibiotics were administered, but the infusion line that was the source of infection was removed, so I looked at the situation as it was.
(8) When the evaluation according to the present example is performed from the result of the blood test on March 24, K increases by +0.13 and Na also increases by +4.2, which is a right-handed type. (Example of the second type)
This change improves peripheral circulation. CRP decreases by -0.83 and inflammation tends to improve, and LDH also decreases by -11 and energy metabolism improves. The overall evaluation according to this example is “◯”, and it can be seen that there is an improvement without administration of antibiotics. From around this time, oral dietary intake has started.
(9) When an evaluation according to this example is performed based on the blood test result on April 9, K decreases by −0.35, Na increases by +2.6, and is in the end atrophy type. (Example of the fourth type)
This change improves cell pump function. CRP decreases by -0.3 and inflammation tends to improve, but LDH increases by +66 and energy metabolism decreases. The overall evaluation is Δ, and care must be taken so that the cell pump function does not deteriorate. The number of meals has increased from two to three, and the nutritional balance is expected to improve.

Case 2: Evaluation of Pneumonia in this Example Case 83-year-old Male (1) A fever occurred on February 22, 2008, and blood tests were conducted using antibiotics until 27th. When the evaluation according to this example was performed from the result of the blood test on February 29, two days later, K increased by +0.56, Na decreased by -3.1, and the end spread type (from 27th to 29th) It has become. (Third type embodiment)
This change reduces the cell pump function. Furthermore, CRP decreases by -0.37 and the inflammatory response tends to improve, but LDH increases by +139 and energy metabolism decreases. The overall evaluation according to this example is x, the condition has not improved completely, and some kind of treatment is necessary.
(2) Antibiotic treatment was started again on February 29, and when the evaluation according to this example was performed based on the blood test results on March 5, K decreased by −0.75 and Na increased by +6.2. And it has become the endless type. (Example of the fourth type)
This change improves cell pump function. Furthermore, CRP is reduced by -0.77, improving the inflammatory response. LDH is also decreased by -186 and energy metabolism is improved. The overall evaluation according to this example is ○○, and the effect of antibiotic administration is evaluated.
(3) When the evaluation according to this example is performed from the result of the blood test on March 12, K decreases by −0.29, and Na also decreases by −0.1, which is a right-down shoulder type. (First type embodiment)
This change results in peripheral circulatory failure. CRP increases by +0.23, spreading the inflammatory response. LDH is decreased by -16 and energy metabolism is improved. The overall evaluation according to this example is xx, and the state is in the direction of deterioration again. It is necessary to select an antibiotic and start treatment, but since the CRP is low, the course is observed without drug administration.
(4) When the evaluation according to the present example is performed from the result of the blood test on March 19, K is decreased by −0.56, and Na is increased by +0.4 to be in the end wilt type. (Example of the fourth type)
This change improves cell pump function. CRP increases by +1.2 and the inflammatory response is still ongoing. LDH increases by +45 and energy metabolism worsens. The overall evaluation according to this example is xx, and the state is still bad. Antibiotics are not administered.
(5) When the evaluation according to this example is performed from the result of the blood test on March 26, K increases by +0.27 and Na also increases by +1.0 to become a right-handed type. (Example of the second type)
This change improves peripheral circulation. CRP decreases by -0.91 and the inflammatory response is improving, while LDH decreases by -70 and energy metabolism is restored. The overall evaluation according to this example is ○, and an improvement due to self-healing power is recognized.
(6) When the evaluation according to the present example is performed based on the blood test result on April 2, K increases by +0.18, and Na increases by +0.2 and rises to the right. (Example of the second type)
This change seems to improve the peripheral circulation, but it may be gradually worsening. CRP increases by +3.38 and the inflammatory response spreads. LDH increases +102 and energy metabolism decreases. The overall evaluation according to this example is xx, and infusion of ATP (adenosine triphosphate) and alpha lipoic acid has been started from the day for improvement of antibiotics and energy metabolism.
(7) When antibiotics were administered for 1 week and the evaluation according to this example was performed based on the blood test results on April 9, K increased by +0.03, Na decreased by -2.1, and became a divergent type. It has become. (Third type embodiment)
This change reduces the cell pump function. On the other hand, CRP decreases by −3.46 and the inflammatory response is improving. LDH is also reduced by -75, improving energy metabolism. The overall evaluation by this example is Δ, and it can be evaluated that administration of an antibiotic or the like is effective.
(8) Although antibiotics were discontinued on April 8, K was increased by +0.27 and Na was decreased by -3.7 when evaluated according to the present example from the results of blood tests on April 14 And it has become a divergent type. (Third type embodiment)
This change reduces the cell pump function. In addition, CRP increases by +0.86, spreading the inflammatory response. LDH also increases by +27 and energy metabolism decreases. The overall evaluation by this example is xxx, and the inflammatory reaction tends to relapse. This is a stage that requires prompt and appropriate treatment.
(9) When an antibiotic was administered from April 15 to April 18 and the evaluation according to this example was performed from the blood test results on April 16, K decreased by −0.5 and Na increased by +0. .2 increased and became endless. (Example of the fourth type)
This change improves cell pump function. On the other hand, CRP increases by +6.02 and the inflammatory response spreads. LDH also increases by +39 and energy metabolism decreases. The overall evaluation according to this example is XX, and the inflammatory reaction continues but tends to improve gradually.

Case 3: Evaluation of pneumonia treatment by this example
84-year-old woman (1) A regular blood test was performed on January 31, 2008. When an evaluation according to this example is performed from a blood test from December 26th to January 31st, K + 0.38 is increased, Na is decreased by −2.0, and a divergent type is obtained. (Third type embodiment)
This change reduces the cell pump function. Furthermore, CRP decreases by −0.18, LDH also decreases by −8, the glycolysis is activated by energy metabolism, and the reaction to the citric acid cycle is considered to be progressing. The overall evaluation according to this example is Δ, and the cell function tends to decrease, but there is no clear infectious disease symptom, and the follow-up is observed.
(2) When the evaluation according to this example is performed based on the blood test results from January 31 to February 28, K increases by +0.16, Na also increases by +0.4, and becomes a right-handed type. Yes. (Example of the second type)
In this change, peripheral circulation is improved, the amount of water in the blood vessel is moderately adjusted, and the concentrations of K and Na are increased. Furthermore, CRP increases by +0.21 and LDH also increases by +126. Although the +0.21 increase in CRP is small, the increase in LDH is large, and a decrease in the energy metabolic system is suspected. The overall evaluation according to this example is xx, and cell function deterioration is suspected. Efforts to improve cell function are necessary.
(3) When an evaluation according to this example is performed from a blood test from February 28 to March 13, K decreases by −0.62 and Na also decreases by −0.1 to become a right shoulder type. Yes. (First type embodiment)
This change is starting to lead to peripheral circulatory failure. Furthermore, CRP is increased by -0.03 and LDH is decreased by -127. The overall evaluation in this example is Δ.
(4) When an evaluation according to this example is performed from a blood test from March 13 to March 17, K is decreased by -0.05, Na is increased by +2.3, and is endemic. . (Example of the fourth type)
With this change, the pump function is beginning to recover. CRP increases by +0.4 and LDH decreases by -2. Some inflammatory condition has occurred and is getting worse. The overall evaluation by this example is x, and treatment for improving inflammation is necessary.
(5) When an evaluation according to the present example is performed from a blood test from March 17 to March 20, K decreases by −0.09 and Na also decreases by −4.5 to become a right shoulder type. Yes. (First type embodiment)
This change results in peripheral circulatory failure. Although CRP is decreased by −0.46, LDH is increased by +16 and energy metabolism is also decreased. The overall evaluation by this example is x, and the state is in the direction of deterioration. Treatment that improves peripheral circulatory conditions is needed.
(6) When an evaluation according to the present example is performed from a blood test from March 20 to March 24, K increases by +0.82 and Na also increases by +0.8 to become a right-handed type ( Second type of embodiment).
This change improves peripheral circulation. However, CRP increases by +2.88, LDH also increases by +59, inflammation occurs, and energy metabolism deteriorates. The overall evaluation according to this example is xx, and the state is getting worse. Antibiotic administration is considered to bring about an early recovery as a countermeasure against infectious diseases.
(7) When an evaluation according to the present example is performed from a blood test from March 24 to March 27, K increases by +0.02 and Na decreases by −0.8 to become a divergent type (No. 1). 3 types of embodiments).
With this change, the cell pump function is reduced. CRP decreased by −2.11 and LDH also decreased by −82, and the inflammatory symptoms due to infection were recovered. The overall evaluation by this example is Δ, and the state is in the direction of improvement.
(8) When an evaluation according to the present example is performed from a blood test from March 27 to April 7, K decreases by −0.36 and Na also decreases by −0.8 to become a right shoulder type. Yes. (First type embodiment)
This change results in peripheral circulatory failure. On the other hand, CRP is reduced by -0.57 and inflammation is improved, and LDH is also reduced by -2 and energy metabolism is improved. The overall evaluation in this example is Δ.
(9) When an evaluation according to the present example is performed from a blood test from April 7 to April 18, K decreases by −0.08, Na increases by +4.2, and is in the end atrophy type. . (Example of the fourth type)
This change improves cell pump function. CRP decreases by -0.25 and inflammation tends to improve, but LDH increases by +1 and energy metabolism decreases. The overall evaluation in this example is Δ. Care must be taken not to degrade the cell pump function.

Case 4 Evaluation of Pneumonia Treatment According to this Example Case 71-year-old Male (1) When the evaluation according to this example is performed from a blood test from February 5 to February 18, 2008, K increases by +0.11; Na has also increased by +1.9, and has become a shoulder-up type. (Example of the second type)
This change improves peripheral circulation. On the other hand, CRP increases by +0.09, LDH also increases by +87, and energy metabolism decreases. The overall evaluation according to this example is XX, the condition is unstable, and some treatment is needed to further improve cell function.
(2) When an evaluation according to the present example is performed from a blood test from February 18 to February 27, K increases by +0.1 and Na also increases by +2.3, which is a right-handed type. (Example of the second type)
This change improves cell pump function. Furthermore, CRP is reduced by -0.18 and the inflammatory response is improved, LDH is also reduced by -99 and energy metabolism is improved. The overall evaluation according to this example is ○, and the symptoms are stable.
(3) When an evaluation according to this example is performed from a blood test from February 27 to March 11, K increases by +0.14 and Na also increases by +8.8, which is a right-handed type. (Example of the second type)
This change improves peripheral circulation. Furthermore, CRP decreased by -0.02, LDH also decreased by -55, and energy metabolism was improved. The overall evaluation according to this example is ○, and the symptoms are in a stable direction.
(4) When an evaluation according to the present example is performed from a blood test from March 11 to March 25, K decreases by −0.95, Na increases by +4.7, and is in the end atrophy type. . (Example of the fourth type)
This change improves cell pump function. On the other hand, CRP increases by +1.12 and an inflammatory reaction occurs. LDH is also increased by +40 and energy metabolism is getting worse. The overall evaluation according to this example is xx, and the symptoms are getting worse.
(5) When an evaluation according to this example is performed from a blood test from March 25 to April 1, K is decreased by −0.44, and Na is decreased by −15 to be a right shoulder type. (First type embodiment)
This change results in peripheral circulatory failure. In addition, CRP increases by +3.81, causing an inflammatory response. LDH is reduced by -32 and energy metabolism is improved. The overall evaluation according to this example is xx, and the symptoms are further worsened. Active treatment with drugs such as antibiotics is necessary.
(6) When the evaluation according to the present example is performed from the blood test from April 1 to April 4, K increases by +0.04, and Na decreases by −1.4 to become a divergent type. (Third type embodiment)
This change reduces the cell pump function. On the other hand, CRP is reduced by −3.74 and the inflammatory response is improved. LDH increases by +9 and energy metabolism decreases. The overall evaluation according to this example is x, which is mild and improves symptoms. It is necessary to continue improving the cell pump function.
(7) When an evaluation according to the present example is performed from a blood test from April 4 to April 8, K increases by +0.58 and Na also increases by +1.3, which is a right-handed type. (Example of the second type)
This change improves peripheral circulation. Furthermore, CRP is reduced by -0.64, improving the inflammatory response. LDH is also reduced by -49, improving energy metabolism. The overall evaluation in this example is ○. It can be evaluated that administration of antibiotics and the like was effective.
(8) When an evaluation according to the present example is performed from a blood test from April 8 to April 16, K decreases by −0.09 and Na also decreases by −5.1 to become a right shoulder type. Yes. (First type embodiment)
This change results in peripheral circulatory failure. Furthermore, CRP increases by +7.67 and the inflammatory response spreads. LDH is reduced by -43 and energy metabolism is improved. The overall evaluation according to this example is xx, and the inflammatory reaction tends to relapse. Immediate treatment with appropriate antibiotics is required.
(9) When an evaluation according to the present example is performed from a blood test from April 16 to April 18, K decreases by −0.07, Na increases by +3.2, and is in the end atrophy type. . (Example of the fourth type)
This change improves cell pump function. Furthermore, CRP is reduced by -3.07, improving the inflammatory response. LDH increases by +57 and energy metabolism decreases. The overall evaluation in this example is Δ, and the inflammatory reaction continues but tends to improve gradually.

Case 5: Evaluation of pneumonia treatment according to this example 83-year-old female (1) When the blood test from February 23 to February 25, 2008 was used to evaluate this example, K decreased by −0.29. , Na is increased by +0.5 and is in the end withering type. (Example of the fourth type)
This change improves cell pump function. Furthermore, CRP is reduced by -0.06, LDH is also reduced by -14, and energy metabolism is improved. The overall evaluation according to this example is ○○, and the inflammatory reaction due to the infection is improved. Treatment is needed to maintain this condition.
(2) When an evaluation according to the present example is performed from a blood test from February 25 to February 28, K decreases by −0.41 and Na also increases by +1 to become the end-wilt type. (Example of the fourth type)
This change improves cell pump function. On the other hand, CRP decreases by −0.11, but LDH increases by +13 and energy metabolism tends to decrease. The overall evaluation according to the present example is Δ, and attention is required because cell function deterioration is beginning to occur.
(3) When an evaluation according to this example is performed from a blood test from February 28 to March 8, K is decreased by −0.51 and Na is increased by +3 to become a end-wither type. (Example of the fourth type)
This change improves cell pump function. Furthermore, although CRP is increased by +2.63, LDH is decreased by -40, and energy metabolism tends to be improved. The overall evaluation according to this example is “x”, and the symptoms are worsening, so active treatment using an antibiotic or the like is necessary.
(4) When an evaluation according to this example is performed from a blood test from March 8 to March 10, K decreases by -0.01, Na increases by +2.7, and is in the end atrophy type. . (Example of the fourth type)
This change improves cell pump function. On the other hand, CRP increases by +3.49, causing an inflammatory reaction. LDH decreases by -51, and energy metabolism tends to improve. The overall evaluation in this example is x. Although the inflammatory response continues, cell function tends to recover, so if you choose an appropriate antibiotic, the symptoms will improve.
(5) When an evaluation according to the present example is performed from a blood test from March 10 to March 12, K increases by +0.01 and Na also increases by +0.8, which is a right-handed type. (Example of the second type)
This change improves peripheral circulation. Furthermore, CRP is reduced by −3.37 and the inflammatory response is improved, while LDH is increased by +39 and energy metabolism is reduced. The overall evaluation according to this example is Δ, and the symptoms are improving. Active treatment with drugs such as antibiotics is necessary in the future.
(6) When an evaluation according to the present example is performed from a blood test from March 12 to March 14, K is increased by +0.26, Na is decreased by -1.2, and is endemic. (Fourth type embodiment).
This change reduces the cell pump function. On the other hand, CRP is reduced by -1.9 and the inflammatory response is improved. LDH is decreased by -9 and energy metabolism is lowered. The overall evaluation by this example is Δ, and the inflammatory symptoms are improved, but it is necessary to continue improving the cell pump function.
(7) When an evaluation according to the present example is performed from a blood test from March 14 to March 24, K is increased by +0.23, Na is decreased by −1.8, and becomes a divergent type (No. 1). 3 types of embodiments).
This change reduces the cell pump function. On the other hand, CRP is decreased by −0.73 and the inflammatory response is improved, while LDH is increased by +51 and energy metabolism is decreased. The overall evaluation in this example is x. Treatment that improves cell pump function is needed.
(8) When an evaluation according to the present example is performed from a blood test from March 24 to April 9, K decreases by −1.13, Na increases by +2, and is in the end atrophy type (No. 1). 4 types of embodiments).
This change improves cell pump function. Furthermore, although CRP is decreased by -0.01, LDH is increased by +5 and energy metabolism is decreased. The overall evaluation in this example is Δ, and the symptoms tend to improve, but it is necessary to continue improving cell function.
(9) When an evaluation according to this example is performed from a blood test from April 9 to April 15, K increases by +1.05, and Na also increases by +2.5, which is a right-handed type. (Example of the second type)
This change improves peripheral circulation. Furthermore, CRP is almost unchanged, LDH is decreased by -15, and energy metabolism is improved. The overall evaluation according to this example is ○, and the symptoms tend to improve.

It is explanatory drawing of the evaluation method of the function of the biological cell of the Example of this invention.

Claims (5)

Detecting a first concentration of one or more elements of K, Na, CRP, and LDH in the blood of a living cell;
After detecting the first concentration, detecting a second concentration in the same element of any one or more of the K, Na, CRP, LDH in the blood;
Calculating the increase or decrease from the first concentration to the second concentration;
A method for evaluating a function of a living cell, characterized by evaluating a state from an increase / decrease to an unaffected stage before the pathological stage of the blood to the pathological stage.   When the second concentration decreases from the first concentration of K and the second concentration decreases from the first concentration of Na, the state of the blood is evaluated as deteriorated. The method for evaluating a function of a living cell according to claim 1.   When the second concentration increases from the first concentration of K and the second concentration increases from the first concentration of Na, it is evaluated that the state of the blood has improved. The method for evaluating a function of a living cell according to claim 1.   When the second concentration is increased from the first concentration of K and the second concentration is decreased from the first concentration of Na, the state of the blood is evaluated as deteriorated. The method for evaluating a function of a living cell according to claim 1. When the second concentration decreases from the first concentration of K and the second concentration increases from the first concentration of Na, the state of the blood is evaluated as improved. The method for evaluating a function of a living cell according to claim 1.

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