JP2011083315A - Local cooling system - Google Patents

Abstract

[PROBLEMS] To perform temperature control accurately so as to keep a local temperature within a predetermined temperature range without restricting the patient's self-sustaining behavior when performing treatment by local cooling for the treatment of epileptic seizures or central nervous system diseases.
A cooling part A installed in a local part includes a Peltier element 1 and a temperature detection sensor 3 provided with a cooling water circulation part 2. The cooling water circulation part 2 is connected to the reservoir 12 of the heat radiating part B by the catheter D, and the cooling water circulates between the cooling water circulation part 2 and the reservoir 12 by the pump 11. The control unit 14 controls the operation of the Peltier element 1 and the pump 11 so that the local part is within a predetermined temperature range based on the local temperature detected by the temperature detection sensor 3. In the case of suppressing epileptic seizures, the cooling part A is provided with an electroencephalogram detection electrode 4 to perform temperature control based on the temperature and the electroencephalogram detection signal. The entire local cooling device, or at least the reservoir 12 and the like, is made into an implantable type.
[Selection] Figure 2

Description

  The present invention relates to a local cooling device, and more particularly to cooling or localizing the brain to prevent or suppress epileptic seizures and to treat central nervous diseases such as cerebrovascular disorders, head trauma, and pain. The present invention also relates to a local cooling device used for cooling a local body part as a treatment.

  Epilepsy patients account for nearly 1% of the total population, and among all epilepsy patients, 30% have refractory epilepsy patients that cannot be treated with medication. Focused resection of epilepsy is an effective treatment for patients with refractory epilepsy or severe epilepsy. However, if severe dysfunction occurs due to resection, use other treatment methods without applying surgery. Should. As alternative treatments, a vagus nerve stimulation device, a skin stimulation device, and the like have been developed, but their effect on suppressing epileptic seizures is not so high. In addition, treatment with whole body hypothermia has been studied, but there are drawbacks such as arrhythmia, coagulation abnormalities, infection, acidosis, and the like, and cooling takes time.

  On the other hand, it has been recognized for some time that the effect of suppressing strong seizures and epileptic seizures can be obtained by cooling the brain local area, and it has been applied to patients with intractable epilepsy (Non-patent Document 1). However, it is not specifically shown about the apparatus which cools a local part efficiently.

  A local cooling device using a Peltier element as a cooling means has also been proposed, and the organ cooling apparatus shown in Patent Document 1 has a Peltier element arranged near the lesioned part of the brain that develops epileptic seizures arranged outside the skull. The transcutaneous energy transmission system is connected to a receiving unit electromechanically, and energy is supplied to the transcutaneous energy transmission system through the scalp, and the Peltier element is driven to cool the lesioned part. In an electroencephalogram control system using an in-brain embedded cerebral cooling device including a Peltier element disclosed in Patent Document 2, a pipe-shaped cooling water passage is brought into contact with and adhered to the heat generating part of the Peltier element, The heat of the heat generating surface of the Peltier element is radiated outside the body.

  Moreover, in patent document 3, the cooling part, the heat pipe, and the heat radiating part which were formed with the metal etc. were connected, and the intracranial embedded cerebrum which transmitted heat to the heat radiating part from the cooling part via the heat pipe. A cooling device is described.

  In the thing of patent document 1, the effective means for efficiently radiating the heat_generation | fever accompanying the cooling effect | action by the Peltier element which is arrange | positioned in the brain vicinity is not provided. In the thing of patent document 2, although the heat of the heat generating surface of a Peltier element is thermally radiated outside by the flowing water of cooling water, no specific countermeasure is taken with respect to the extracorporeal heat radiating part. It is installed at the bedside and the patient's free behavior is restricted.

  The thing of patent document 3 does not use a cooling means like a Peltier element as a local cooling part, but is not an active cooling mode, and the heat conduction performance of the material constituting the cooling part and the heat pipe. This is also disadvantageous from the viewpoint of cooling efficiency.

JP 2006-141993 A Japanese Patent No. 3843054 JP 2007-209523 A

Ommaya, AK, et al, Journalof Neurosurgery, 20, p.8-20, 1963

  It has been known so far that cooling the brain region has a great effect as a treatment for suppressing seizures of refractory epilepsy. It is necessary to provide effective cooling means for effectively cooling the local area so as to suppress the epileptic seizure without affecting it, and to appropriately adjust and control the local cooling.

  In conventional local cooling devices, effective measures are not taken for heat dissipation treatment, the local temperature is not accurately controlled, and even if epileptic seizures are suppressed, cerebral ischemia, metabolic abnormalities, neuronal disorders The risk of side effects such as was not considered. For this reason, a good effect on the prevention of epileptic seizures was not obtained, and there were many problems in clinical applicability for the prevention of epileptic seizures. Furthermore, in the case where the extracorporeal heat radiating portion is installed on the bedside, the patient's free behavior is restricted.

  Under these circumstances, when performing epileptic seizure suppression by local cooling, heat dissipation treatment is performed accurately, temperature control is performed accurately, and the local cooling device is implanted in the body to limit the free behavior of the patient. There has been a need to provide a local cooling device that has been eliminated. In addition, it is effective to cool the local area in the treatment of central nervous disease such as cerebrovascular disorder, head trauma, and pain. In such a case, it is required to apply the local cooling apparatus in the same way. It was.

  The present invention has been made to solve the above-described problems, and a local cooling device according to the present invention includes a Peltier element provided with a cooling water circulation part in a casing and provided with a temperature detection sensor. Integrated connection of a cooling unit embedded in a cooling location, a catheter connected to the cooling unit and circulatingly circulating the cooling water to the cooling water circulation unit, and wiring to each of the Peltier element and the temperature detection sensor A cooling water circulating operation connected to the catheter of the connecting and connecting portion, a heat radiating portion including a reservoir in which cooling water stays, a Peltier element and a temperature detection sensor in the cooling portion, and a pump in the heat radiating portion A control unit for controlling the Peltier element and the pump so as to cool the cooling point to a predetermined temperature based on the detected temperature connected to the wiring, and a power supply unit It includes a, in which the at least the cooling portion and the connecting connecting unit control unit is embedded in the body.

  The cooling unit further includes an electroencephalogram detection electrode, and the connection portion further includes wiring for connecting the electroencephalogram detection electrode and the control unit, and the control unit uses the temperature detection sensor and the electroencephalogram detection electrode, respectively. The Peltier element and the pump may be controlled so as to cool the cooling point to a predetermined temperature based on the detected temperature and the electroencephalogram detection signal.

  All the parts including the heat radiating part and the power source part may be embedded in the body, and the control part may be provided with a transmission / reception means so that operations relating to setting / operation can be performed by a remote controller outside the body.

  A local cooling device according to the present invention includes a Peltier element, a Peltier element operating unit, a temperature detection sensor, a first transmission / reception unit, and a first power supply unit provided with a cooling water circulation unit. A cooling unit embedded in the cooling part, a catheter connected to the cooling unit for circulating and transferring the cooling water to the cooling water circulation unit, a pump connected to the catheter for circulating the cooling water, and a reservoir in which the cooling water stays And a second power supply unit, and a temperature detection signal from a temperature detection sensor in the cooling unit passes through the first transmission / reception unit. Is transmitted to the second transmission / reception unit of the control unit, and the control unit receives the temperature detection signal received by the second transmission / reception unit and controls the operation of the pump that performs the cooling water circulation operation in the heat dissipation unit. The operation command signal of the Peltier element in the cooling unit is generated, transmitted to the first transmitting / receiving unit of the cooling unit via the second transmitting / receiving unit, and received by the first transmitting / receiving unit of the cooling unit Based on the command signal, the Peltier element is operated to control the required cooling point to a predetermined temperature, and at least the cooling part, the catheter, and the control part are embedded in the body.

  In the cooling unit, an electroencephalogram detection electrode is further provided, and the first transmitting / receiving unit transmits an electroencephalogram detection signal in addition to the temperature detection signal, and the control unit requires a cooling point based on the temperature detection signal and the electroencephalogram detection signal. The Peltier element and the pump may be controlled so as to cool to a predetermined temperature.

  All the parts including the heat radiating part and the power supply part for the operation of the pump in the control part and the heat radiating part are embedded in the body, the control part is provided with transmission / reception means, and is related to setting / operation by a remote controller outside the body. Operation may be performed.

  It may be used as an epileptic seizure suppression device, and the cooling unit may be installed in the cranium in contact with the brain surface to control the brain surface temperature in a temperature range of 15 to 25 ° C.

  A local cooling device according to the present invention includes a cooling unit having a Peltier element, a connecting / connecting unit that circulates cooling water, a heat radiating unit having a reservoir, and a control unit. The main part is embedded in the body or entirely in the body. It can be used as an embedding form so as not to restrict the self-sustaining behavior of the patient who performs the local cooling treatment, and the cooling can be accurately controlled so that the required cooling point is within a predetermined temperature range. When applied for the prevention of epileptic seizures, seizures can be suppressed while maintaining normal brain function. In addition, cooling can be effectively performed when the brain local area is cooled for the treatment of central nervous diseases such as cerebrovascular disorder, head injury, and pain. As a result, even if an epileptic focus exists in a motor area or a language area, which could not be excised due to the possibility of dysfunction in the past, it can be treated.

It is a figure which shows roughly the form which installs the local cooling device by this invention. It is a figure which shows the structural example of the local cooling device by this invention. It is a figure which shows the other structural example of the local cooling device by this invention. It is a figure which shows the structural example of the control system in the local cooling device by this invention.

  The local cooling device according to the present invention is configured in a form that can be used as a main part or entirely as an implantable type so as not to restrain the patient's daily independence life in use. FIG. 1 shows the situation when using this local cooling device for the control of epileptic seizures. The local cooling device is a cooling unit A disposed close to the brain surface inside the skull, and a heat radiating unit B. And a control part C, a connection part D including a catheter for connection between the cooling part A, the heat radiation part B and the control part C, and a power supply part E.

  In the case of a completely embedded type, the parts A to E are embedded in the body as a whole, but for the heat radiating part B, the heat radiating effect is improved, and for the power source part E, the rechargeable battery is replaced. For convenience, it may be exposed outside the body and the other part may be embedded in the body.

  FIG. 2 shows the configuration of each part A to E in FIG. The cooling part A is a part arranged close to the brain surface part in the skull. Reference numeral 1 denotes a Peltier element for cooling the brain surface part. A cooling water circulation part 2 is disposed on the heat radiation surface side of the Peltier element 1 so that heat is transferred from the heat radiation surface by the cooling water. 3 is a thermocouple as a temperature detection sensor, and 4 is an electroencephalogram detection electrode (ECoG electrode). The cooling part A is configured by housing these elements integrally in a casing so that the outer shape is as thin and smooth as possible and easy to install on the brain surface. As the covering material to be the casing 10, the brain surface contact portion (the cooling surface side of the Peltier element) is made of a material such as silver having a high biological safety and a high thermal conductivity, and the other portion is a titanium having a low thermal conductivity, A material such as platinum is used. The thermocouple 3 is provided so as to be embedded in the wall of the casing 10. The electroencephalogram detection electrode 4 is preferably installed in such a manner that a silver-silver chloride electrode of about φ100 to 500 μm coated with a thin insulator at the four corners of the cooling part A penetrates the casing 10 wall.

  The cooling water circulation part 2 is connected to a catheter composed of a cooling water inflow path and a cooling water outflow path, and the cooling water inflow path and the cooling water outflow path are connected to the heat radiating part B through the connection connecting part D. A wiring 5 for transmitting a detection signal by the thermocouple 3, a wiring 6 for transmitting a detection signal by the electroencephalogram detection electrode 4, and a wiring 7 for receiving the operating current of the Peltier element 1 are connected to the control unit via the connection part D, respectively. The connection D is shown as an overview of the catheter and wirings 5, 6 and 7 consisting of the cooling water inflow and outflow paths. In the connection D, the catheter is integrated and covered with the wiring. It is good to do. In this case, a material such as polypropylene having good biocompatibility is preferably used as the covering material.

  The sheathing material for the catheter or the catheter and the wiring disposed along the catheter is formed of a flexible resin material, but the catheter is rigid in order to prevent deformation when it is bent or crushed by external pressure when implanted in the body. It is preferable to use one reinforced with a large helical wire.

  The heat radiating section B includes a cooling water circulation small pump 11, a cooling water reservoir 12, and a cooling section 13. The reservoir 12 is a flexible bag-like container such as a pouch. The cooling water circulation small pump 11 circulates and transfers the cooling water from the reservoir 12 to the cooling water circulation portion 2 through the inflow conduit of the connecting connection portion D, and removes heat from the heat radiation surface of the Peltier element 1. The cooling water whose temperature has risen after passing through the cooling water circulation part 2 is transferred to the reservoir 12 through the outlet pipe of the connection part D.

  The cooling unit 13 reduces the temperature of the cooling water whose temperature has increased in the reservoir 12. The cooling unit 13 is a part that acts to lower the temperature of the cooling water stored in the reservoir 12 in this way. If the part of the reservoir 12 is exposed outside the body, the heat radiation area on the outer surface of the reservoir 12 is increased. However, when the reservoir 12 is embedded in the body, no specific means is provided, and the reservoir 12 is embedded in the portion where the reservoir 12 is embedded. Heat is released from the skin surface. In order to enhance heat dissipation, auxiliary means such as a capsule with a cold-reserving agent in the form of use as described later gives an action as a cooling section.

  The control unit C receives the temperature detection signal from the thermocouple 3 and the signal of the electroencephalogram detection electrode, performs signal processing, and performs cooling operation by the Peltier element 1 and cooling water circulation by the cooling water circulation pump so that the temperature of the brain local part becomes appropriate. Control the behavior. In the control unit C, the electroencephalogram analysis is performed on the electroencephalogram detection signal by a method such as independent principal component analysis or short-term FFT analysis, the necessity of cooling the epileptic seizure focus is determined, and the necessity of the cooling operation is determined. Control is performed to start the cooling operation occasionally and stop the cooling operation when the necessity for the cooling operation is no longer needed, and according to the set target temperature value and the detected temperature value during the cooling operation To perform PID control. The control unit C has a program for the control.

  The control target temperature varies depending on the symptoms and degree of epileptic seizures, but is preferably 15 to 25 ° C. In order to suppress epileptic seizures, it is generally better to cool the local area to 25 ° C. or lower, and cooling to 15 ° C. or lower may lower the physiological function.

  The control unit C is configured using an IC, and includes a setting unit for variable adjustment of temperature and the like. This setting unit is provided at a position where it can be operated outside the body, or when the control unit C is embedded, the control unit C includes a transmission / reception unit, and a signal is transmitted / received by a remote operation device outside the body. A configuration operation is performed. The power supply unit E supplies power to the control unit C, the cooling water circulation pump 11, the Peltier element 1, the thermocouple 3, and the electroencephalogram detection electrode 4, and is composed of a rechargeable battery or the like. Of the heat dissipating part B, the control part C, and the power supply part E, the parts embedded in the body are covered with a covering material made of a material such as polypropylene having good biocompatibility.

  As the cooling water, physiological saline, Ringer's solution, pure water or the like, which has a relatively large specific heat and whose biological safety is guaranteed, is used. As a usage form of the local cooling device of the present invention, there are a case where it is used as an in-vivo implant type as a whole, and a case where a part such as a reservoir and a power supply part is fixed to be exposed outside the body and the other part is set in an in-vivo form. is there. As a local cooling device for the control of epileptic seizures, the cooling part A is embedded in the brain surface of the focal point of epileptic seizures in the cranium, and the connecting connection part D is embedded under the neck skin. The heat radiating part B, the control part C, and the power supply part E are embedded or partially exposed and fixed.

  When the part of the heat radiation part B including the reservoir 12 is embedded in the body, heat is radiated from the body or the skin surface. If such heat release is within a certain range, homeotasis is maintained and the influence on the living body can be ignored. Alternatively, in order to further enhance the heat dissipation, a capsule containing a cryogen may be disposed in contact with the skin surface, or may be used at any time. In this case, the capsule containing the cryogen is used by replacing it with a precooled one when the temperature rises with time. In the form in which the heat radiating part C is exposed to the outside of the body, the part of the reservoir 12 containing the cooling water is naturally radiated in the environment outside the body, or the form in which the heat radiation is enhanced by contacting the capsule with the cryogen. it can.

  When the reservoir is embedded in the body, it is gradually cooled in the body, so the size of the reservoir is increased to some extent (about 500 mL to 1 L), and smaller when performing auxiliary cooling with a cryogen or the like. (50-100 mL).

  FIG. 3 shows a configuration of a local cooling device configured to transmit and receive signals between the cooling unit and the control unit without using a wiring. Basically, cooling is performed in the same manner as in FIG. A part A, a heat radiating part B, a control part C, a connection connecting part D consisting of only a catheter, and a power supply part E are provided.

  The cooling unit A includes a Peltier element 1, a cooling water circulation part 2 on the heat dissipation surface side of the Peltier element, a thermocouple 3 as a temperature detection sensor, and an electroencephalogram detection electrode (ECoG electrode) 4 as an electroencephalogram detection sensor. It is disposed so as to be embedded in the wall portion of the casing 10 on the contact surface side, and further includes a transmission / reception unit 8 and a power supply unit 9. The thermocouple 3 and the electroencephalogram detection electrode 4 are connected to the transmission / reception unit 8, and the transmission / reception unit 8 transmits detection signals from the thermocouple 3 and the electroencephalogram detection electrode 4, and receives an operation command for the Peltier element from the control unit. Receive a signal. The power supply unit 9 is a power supply for the operation of the Peltier element 1 and the transmission / reception unit 8.

  As in the case of FIG. 2, the heat dissipating part B includes a cooling water circulation small pump 11, a cooling water reservoir 12, and a cooling unit 13. A transmission / reception unit 14 is attached to the control unit C and performs transmission / reception with the transmission / reception unit 8 in the cooling unit A. The catheter D forms a cooling water circulation path connected between the cooling water circulation section 2 of the cooling section A and the reservoir 12, and the cooling water is circulated by the operation of the pump 11.

  FIG. 4 is a diagram showing a control system in the local cooling device of the present invention, including a fail-safe system. The control unit C in FIGS. 2 and 3 is divided into a control circuit 21, an operation circuit 22, and a fail-safe circuit 23 here. The control circuit 21 receives signals from the thermocouple 3 and the electroencephalogram detection electrode 4 and sends a command signal for the cooling operation by the Peltier element 1 and the operation of the cooling water circulation pump 11 in the heat radiating section B to the operation circuit 22. The operation circuit 22 performs a cooling water circulation pump 11 (shown in FIG. 4) of the Peltier element 1 and the heat radiating section B through operations such as switching of the power supplied from the power supply section E and current control in response to a command signal from the control circuit 21. Is not controlled). A fail-safe circuit 23 receives signals sent from the thermocouple 3 and the heat radiating part B, and sends an operation stop command signal to the operation circuit 22 when it is determined that the local cooling device cannot be controlled. Reference numeral 24 denotes an operation unit for stopping the operation of the local cooling device as a manual operation.

  In the local cooling device shown in FIG. 2 and FIG. 3, in order to control the cooling of the body-required cooling point by the control unit C so as to be within a predetermined temperature range, a target temperature value is set for cooling, etc. It is desirable to be able to vary as needed. An operation unit for setting the target temperature value and starting / stopping the operation of the local cooling device is provided in a form in which the control unit C is connected to the control unit C when the control unit C is exposed outside the body. In the form in which the part C is embedded in the body, the control part C is provided with a transmission / reception part so as to perform an operation for setting a target temperature value and starting / stopping the operation of the local cooling device by an operation command from the remote controller. To do.

  In FIG. 4, the thermocouple 3, the electroencephalogram detection electrode 4 and the control circuit 21, and the thermocouple 3 and the fail safe circuit 23 are connected by wiring, and correspond to the configuration shown in FIG. As a configuration corresponding to the configuration shown in FIG. 3, signals from the thermocouple 3 and the electroencephalogram detection electrode 4 are transmitted through the transmission / reception unit, and the functions of the operation circuit 22 and the power supply unit E include the Peltier element 1. The control form based on the detection signal is basically the same. The manual operation unit 24 can be operated wirelessly via the transmission / reception unit when the control unit C is embedded in the body.

  In order to confirm the effect of the local cooling device according to the present invention, animal experiments are conducted. When an epileptic seizure is induced by administration of penicillin G or cobalt powder to a male rat, a cooling part containing a Peltier element is embedded in the SI-MI cortex, the target temperature is set to 15 ° C., and local cooling is performed. The brain surface was kept at 15 ° C. without a shoot, and seizures were suppressed while maintaining normal function. The cerebral circulation during cooling decreased but was not significant, and recovered rapidly upon rewarming, and glutamate and lactic acid decreased in terms of metabolism. For this reason, the brain protective action by extracellular glutamate suppression is suggested, the lactic acid which raises by ischemia is suppressed, and the possibility of ischemia is denied. Neurologically, there was no effect other than a slight decrease in sensory / motor function at 15 ° C cooling. Moreover, as a result of embedding a cooling part and cooling to 20 ° C. continuously for one month, no histological effects were observed other than mild gliosis.

  Based on the above results, clinical experiments were conducted. As a result of cooling the epileptic focal site of refractory epilepsy patients (6 patients) to 15-25 ° C during the operation, suppression of abnormal electroencephalogram was confirmed, ischemia due to cooling was not observed, and glutamic acid and lactic acid decreased in terms of metabolism Brain protection was observed, and no abnormalities were observed in ECG and blood pressure.

  The above-described local cooling device according to the present invention is configured so that the main part or the whole is implanted in the body, does not restrict the patient's self-sustaining behavior, and can accurately control the cooling point to be cooled within a predetermined temperature range. it can. Moreover, although the local cooling device by this invention was demonstrated as the thing of the form applied for the epileptic seizure suppression, it can apply also in the other case where the treatment by local cooling is effective.

  Specifically, it is also applied to cases of other central nervous diseases such as cerebrovascular disorders, head trauma, and pain. In cerebrovascular disorders and head injuries, the fact that local cooling of the brain produces a remarkable protective action on the brain has been clarified, and applying the local cooling device according to the present invention is an effective therapeutic means. In these diseases, an increase in excitability of neurons mainly composed of glutamate occurs, and therefore, the increase in excitability can be monitored with an electroencephalogram electrode and controlled by temperature. As for pain, it is clear that neurons that process pain exist in the cortex, and neurotransmission of these neurons can be suppressed by local brain cooling.

  2 to 4 show a configuration form of a local cooling device that cools the brain locally to suppress epileptic seizures, and an electroencephalogram detection signal obtained by an electroencephalogram detection electrode and a temperature detection obtained by a temperature detection sensor. Based on the signal, the brain part is controlled so as to reach a predetermined temperature. Generally, when the brain wave detection is not particularly required when cooling a portion requiring cooling, the brain wave detection electrode is used as a local cooling device. It is not necessary to prepare. As described above, in the local cooling device not particularly provided with the electroencephalogram detection electrode, the local part is controlled to have a predetermined temperature according to the PID control function provided as a control circuit based on the temperature detection signal obtained by the temperature detection sensor. It is.

  Moreover, in the form of the local cooling device shown in FIGS. 2 to 3, the heat radiating part B, the control part C, and the power supply part E are shown as integral parts, and these correspond to the case where they are entirely embedded in the body. However, for example, when the part of the heat radiating part B is exposed outside the body, the heat radiating part B, the control part C, and the power supply part E are configured separately.

A cooling part B heat radiation part C control part D connection connection part E power supply part 1 Peltier element 2 cooling water circulation part 3 thermocouple 4 EEG detection electrode 5 wiring 6 wiring 7 wiring 8 transmission / reception part 9 power supply part 10 casing 11 small pump 12 reservoir 13 Cooling unit 14 Transmission / reception unit 21 Control circuit 22 Operation circuit 23 Fail-safe circuit 24 Operation unit

Claims (7)

  A cooling part embedded in a body-required cooling point, in which a Peltier element provided with a cooling water circulation part is accommodated in a casing and a temperature detection sensor is attached, and connected to the cooling part and connected to the cooling water circulation part. A connecting connection part in which a catheter that circulates and transports and wiring to each of the Peltier element and the temperature detection sensor are integrated, a pump that performs a circulating operation of cooling water connected to the catheter of the connecting connection part, and cooling water stay The Peltier is cooled to a predetermined temperature on the basis of the temperature detected by connecting to the heat radiating part having a reservoir, the Peltier element and temperature detection sensor in the cooling part, and the pump in the heat radiating part via wiring. A control unit that controls the element and the pump, and a power supply unit, and at least the cooling unit, the connecting and connecting unit, and the control unit are embedded in the body Local cooling device, characterized in that there.   The cooling unit further includes an electroencephalogram detection electrode, and the connection portion further includes wiring for connecting the electroencephalogram detection electrode and the control unit, and the control unit uses the temperature detection sensor and the electroencephalogram detection electrode, respectively. 2. The local cooling device according to claim 1, wherein the Peltier element and the pump are controlled so as to cool the cooling point to a predetermined temperature based on the detected temperature and the electroencephalogram detection signal.   2. All the parts including the heat radiating part and the power source part are embedded in the body, and the control part is provided with a transmission / reception means, and an operation related to setting / operation can be performed by a remote controller outside the body. 2. The local cooling device according to any one of 2 above.   A Peltier element provided with a cooling water circulation part, a Peltier element operating part, a temperature detection sensor, a first transmission / reception part, a cooling part embedded in a body-required cooling part that houses a first power supply part in a casing, A catheter connected to the cooling section for circulating and transferring cooling water to the cooling water circulation section; a heat radiation section including a pump connected to the catheter for circulating the cooling water and a reservoir for storing the cooling water; A control unit including a transmission / reception unit and a control circuit, and a second power supply unit, and a temperature detection signal from a temperature detection sensor in the cooling unit is transmitted and received by the control unit via the first transmission / reception unit. The control unit receives the temperature detection signal received by the second transmission / reception unit, controls the operation of the pump that performs the cooling water circulation operation in the heat radiating unit, and An operation command signal for the element is generated and transmitted to the first transmission / reception unit of the cooling unit via the second transmission / reception unit, and based on the operation command signal received by the first transmission / reception unit of the cooling unit. A local cooling device characterized in that a Peltier element is operated to perform control so that a portion requiring cooling reaches a predetermined temperature, and at least the cooling unit, the catheter, and the control unit are embedded in the body.   In the cooling unit, an electroencephalogram detection electrode is further provided, and the first transmitting / receiving unit transmits an electroencephalogram detection signal in addition to the temperature detection signal, and the control unit requires a cooling point based on the temperature detection signal and the electroencephalogram detection signal. The local cooling device according to claim 4, wherein the Peltier element and the pump are controlled so as to cool the air to a predetermined temperature.   All the parts including the heat radiating part and the power supply part for the operation of the pump in the control part and the heat radiating part are embedded in the body, the control part is provided with transmission / reception means, and is related to setting / operation by a remote controller outside the body. 6. The local cooling device according to claim 4, wherein the local cooling device can be operated. 2. The epileptic seizure suppression device is used, wherein the cooling unit is installed in the skull in contact with the surface of the brain, and the temperature of the surface of the brain is controlled in a temperature range of 15 to 25 ° C. The local cooling device in any one of -6.

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