JP2011012004A - External preparation composition for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an external preparation composition for the skin, forming a film on the skin by being coated, capable of preventing the contact of bacteria or the like with the skin, also capable of preventing rough skin, and having improved sense of use by reducing the sticky feeling and smell of the external preparation composition for the skin itself.SOLUTION: The external preparation composition for the skin, forming the film on the skin contains an aminoethylaminopropylsiloxane-dimethylsiloxane copolymer, a perfluoro polyether and a polyvinylpyrrolidone. As a result, the contact of the bacteria or the like with the skin, and the rough skin can be prevented by forming the film comprising a first layer of the aminoethylaminopropylsiloxane-dimethylsiloxane copolymer, a second layer of the perfluoro polyether and a third layer of the polyvinyl pyrrolidone, and the sense of use can be improved by suppressing the sticky feeling and the smell to low levels.

Description

  The present invention relates to a skin external preparation composition that forms a film on the skin.

  In the medical field, thorough hand washing and disinfection are promoted to strengthen hospital infection prevention measures. However, moisturizing components of the skin are lost due to the effects of surfactants and alcohol contained in detergents and disinfectants. Then, rough skin such as rough hands is increasing. When rough skin occurs, bacteria and the like are likely to propagate on the skin, which is not preferable, and it may be painful due to itching or inflammation.

  In order to prevent this rough skin, skin care products such as hand cream (lotion) intended to supplement lost moisturizing ingredients are widely used. However, frequent hand washing and the like are required particularly in the medical field, but the moisturizing component is washed away each time, and skin care with hand cream is not sufficient to prevent rough skin.

  Therefore, an external preparation for skin that forms a film on the skin by applying before work to prevent rough skin has been proposed, and an external preparation for skin containing dimethicone and polyvinylpyrrolidone, or an external preparation for skin containing an acrylic polymer (For example, Patent Document 1) is known. However, the coating film formed by these known external preparations for skin is also easily peeled off by hand washing or the like as in the case of hand cream, and rough skin cannot be sufficiently prevented.

  In addition, these conventional external preparations for skin contain a large amount of an oil component so as to increase the viscosity so that peeling of the film by hand washing as described above can be prevented as much as possible. Therefore, the conventional skin external preparation has a lot of stickiness, and the workability may be lowered by application of the skin external preparation. In addition, it has a strong odor due to the effect of oil content. That is, the conventional external preparation for skin has a problem that the feeling of use is poor because of stickiness and odor, and there is a fact that its use is hesitant in the medical field.

JP 2008-1000096 A

  As described above, conventional skin external preparations that form a coating have a weak effect of preventing rough skin, and also have a poor feeling of use due to stickiness and smell. Furthermore, since it is used also in the field of medical treatment, it is desirable that the coating formed on the skin can suppress contact of microorganisms, bacteria, and the like with the skin as compared with the conventional case.

  The present invention has been made based on such circumstances, and is an external preparation composition for skin that forms a film on the skin, which can suppress contact of microorganisms and bacteria with the skin, and prevent rough skin. An object of the present invention is to provide a skin external preparation composition that is capable of improving the usability compared to the prior art.

  As one aspect of the present invention, the present invention provides a skin external preparation composition capable of forming a film on the skin by application, and comprises an aminoethylaminopropylsiloxane / dimethylsiloxane copolymer, perfluoropolyether, and polyvinylpyrrolidone. It is characterized by containing.

  ADVANTAGE OF THE INVENTION According to this invention, the contact with skin of microorganisms, bacteria, etc. can be suppressed with the film formed on skin with the component to contain rather than the case where the conventional skin external preparation is used. Moreover, compared with the conventional skin external preparation, since it is hard to peel, for example by hand washing etc., rough skin can be prevented. Furthermore, since the stickiness and odor of the external preparation for skin itself can be suppressed as compared with the conventional case, the feeling of use can be improved.

  Hereinafter, preferred embodiments of the present invention will be described in detail.

  This embodiment is a skin external preparation composition that forms a film that can be applied to the skin to penetrate and cover the stratum corneum of the skin and prevent the outflow of moisturizing components when hand washing or disinfecting. is there. The skin external preparation composition is characterized by containing an aminoethylaminopropylsiloxane / dimethylsiloxane copolymer, perfluoropolyether, and polyvinylpyrrolidone.

  The aminoethylaminopropylsiloxane / dimethylsiloxane copolymer is one of amino-modified silicones, and in the preparation of the skin external preparation composition of the present embodiment, the molecular weight and the like are not particularly limited. Those of ordinary skill in the art can appropriately select those according to the dosage form. Similarly, the viscosity and amino equivalent amount can be appropriately set by those skilled in the art according to the dosage form. A publicly known thing can be used in this embodiment, and, specifically, Toray Dow Corning, Silicone SF8452C, Momentive Performance Materials Japan, XF42-B1989, etc. can be illustrated. The aminoethylaminopropylsiloxane / dimethylsiloxane copolymer has an amino acid skeleton and is highly adsorbable to the stratum corneum. When the skin external preparation of this embodiment is applied, it penetrates into the stratum corneum of the skin to form the first coating layer, and the formed coating has high adhesion to the skin and high persistence on the skin. Give. Here, in this embodiment, it is preferable to contain 0.01-20.0 mass% of aminoethylaminopropylsiloxane dimethylsiloxane copolymer with respect to the said skin external preparation, 0.10-5.00. It is still more preferable to contain by mass%. When the ratio is smaller than 0.01% by mass, the film forming ability is worse than when the ratio is within the range. On the other hand, when the ratio is larger than 20.0% by mass, it becomes stickier than when it is within the range, and the feeling of use becomes worse.

  The perfluoropolyether used in the present embodiment is not particularly limited with respect to the average molecular weight and the like, and can be appropriately set by those skilled in the art according to the dosage form. Specifically, known products (for example, FOMBLIN HC / 25 from Nikko Chemicals Co., Ltd., demnum S from Daikin Industries, Ltd.) can be appropriately selected and used. When the skin external preparation of this embodiment is applied, the perfluoropolyether forms a second coating layer on the first coating layer by the aminoethylaminopropylsiloxane / dimethylsiloxane copolymer described above, and the skin The film formed on the surface is imparted with a property that is not easily adapted to water or oil. Here, in this embodiment, it is preferable to contain perfluoropolyether 0.01-10.00 mass% with respect to the said skin external preparation, and 0.1-5.00 mass% is contained further. preferable. When the ratio is smaller than 0.01% by mass, the film formation is insufficient as compared with the case where the ratio is within the range. On the other hand, when the ratio is greater than 10.00% by mass, the feeling in use is worse than when the ratio is within the range.

  Furthermore, the skin external preparation of this embodiment contains polyvinylpyrrolidone (PVP). In the present embodiment, for example, PVP having a K value of 27.0 to 33.0 (for example, PVP-K30W of Nippon Shokubai Co., Ltd., Rubiscor K30 of BASF, Krigers K, etc.) can be used. It does not specifically limit and it can set suitably by those skilled in the art according to a dosage form. The K value is a viscosity characteristic value that correlates with the molecular weight. For example, as described in JP-A-2007-277378, a 1 wt% aqueous solution of PVP is measured with a capillary viscometer at 25 ° C., It can be determined by the following viscosity equation of the fixture.

In the formula, η _rel is the relative viscosity, c is the concentration (g / mL) of the PVP aqueous solution, and k ₀ is a variable related to the K value. The higher the K value, the higher the molecular weight of PVP.

  When the skin external preparation of this embodiment is applied, polyvinylpyrrolidone forms a third coating layer on the second coating layer made of the above-mentioned perfluoropolyether. Polyvinylpyrrolidone forms a hydrogel containing a large amount of water around the molecule, thus further improving the adhesion and persistence of the coating. Here, in this embodiment, it is preferable to contain 0.01-10.00 mass% of polyvinylpyrrolidone with respect to the said skin external preparation, and it is still more preferable to contain 0.10-5.00 mass%. When the ratio is smaller than 0.01% by mass, the film is insufficient as compared with the case where the ratio is within the range. On the other hand, when the ratio is larger than 10.00% by mass, the creaming is worse than in the range, and the feeling of use is not good.

  That is, the skin external preparation composition of the present embodiment, when applied, covers the stratum corneum layer of the skin, the first coating layer of aminoethylaminopropylsiloxane / dimethylsiloxane copolymer, and the first coating layer of perfluoropolyether. A coating composed of two coating layers and a third coating layer made of polyvinylpyrrolidone is formed. The film formed in this way does not allow microorganisms and bacteria to permeate more than the film formed by the conventional external preparation for skin because the respective components interact with each other. That is, according to the skin external preparation composition of the present embodiment, it is possible to suppress the contact with the skin surface such as microorganisms and bacteria and permeation into the stratum corneum than before.

  Moreover, the skin external preparation composition of this embodiment can counter many external stimuli, such as hand-washing and disinfection, and has a higher rough skin prevention effect compared with the conventional skin external preparation. Specifically, the coating formed by the external preparation composition for skin according to the present embodiment is formed because it is difficult to adapt to water and oil, and the coating has high adsorptivity and persistence to the skin. Even when the film is washed by hand as compared with the conventional skin external preparation composition, it is difficult to peel off. In other words, the coating of the external preparation for skin according to the present embodiment greatly suppresses peeling from the skin due to the interaction between the property that it is difficult to adapt to water and oil and the high adsorbability and persistence to the skin. Is done. Therefore, since the film is maintained on the skin for a long time even by hand washing or the like, it is possible to suppress rough skin as compared with the conventional case.

  Furthermore, according to the skin external preparation composition of the present embodiment, since the formed film is more firmly maintained on the skin, in order to suppress peeling of the film by hand washing or the like in the conventional skin external preparation composition It is possible to reduce the amount of the oil component contained in a large amount. Therefore, it is possible to improve the feeling of use by suppressing stickiness and smell. Furthermore, since the viscosity can be suppressed, the container to be filled can be easily transferred, so that convenience in use can be improved and the environment is preferable.

  In addition, since the film of the external preparation composition for skin according to the present embodiment is difficult to adapt to water and oil as described above, it is necessary to penetrate into the stratum corneum also about components that are a source of dirt and odor and irritants. Can be suppressed. In other words, it is possible to easily remove dirt, odors, and irritants on the skin by hand washing.

  In addition to the above-described components, the skin external preparation composition of the present embodiment can be optionally used in various cosmetics, quasi-drugs, pharmaceuticals and the like as long as the effects of the present invention are not impaired. A component can be added and it can be set as various forms, such as liquid form, solid form, paste form, gel form, and an emulsion.

  Specifically, as various optional components, base materials such as water, emulsifiers and emulsion stabilizers, oil components, emollients (softening agents), moisturizers, pH adjusters, antioxidants, plant extracts, UV protection agents , Anti-inflammatory components, preservatives, fragrances and the like.

  Among these, as this component moisturizer, for example, pyroglutamate isostearate polyoxyethylene glyceryl and glycerin which are derivatives of pyrrolidone carboxylic acid (PCA) which is one of natural moisturizing components (NMF). it can. However, the present invention is not limited to this, and various humectants can be used. Specifically, polyhydric alcohols such as polyethylene glycols, propylene glycol and dipropylene glycol, sorbitol, mannitol, xylitol, Examples include saccharides such as tall, amino acids, urea, hyaluronic acid, and water-soluble polymers.

  Examples of the oil component include oil agents such as animal and vegetable oils, ester oils, and mineral oils.

  The emulsifier can be of nonionic type, cationic type, anionic type, and examples of the emulsion stabilizer include cetyl alcohol, stearyl alcohol, alcohols of behenyl alcohol, etc. Absent.

  Examples of emollients include esters such as isopropyl myristate.

  Examples of the pH adjuster include basic amino acids such as triethanolamine, isopropanolamine, diisopropanolamine, L-arginine and L-lysine, metal oxides such as sodium hydroxide, potassium hydroxide and lithium hydroxide, urea, ε-aminocaproic acid, sodium pyrrolidonecarboxylate, sodium hydrogen phosphate, sodium citrate, citric acid, lactic acid, succinic acid, tartaric acid and the like can be mentioned. In addition, it is preferable to make the skin external preparation composition of this embodiment into the area | region of pH 5.0-9.0 by these pH adjusters.

  Examples of the preservative include triclosan, phenoxyethanol, and parabens.

  Further, stearyl glycyrrhizinate and tocopherols known as vitamin E may be included. All of these have been reported to have anti-inflammatory, antioxidant and blood flow promoting effects.

  The skin external preparation composition of the present embodiment can be produced according to a usual method, and may be any form such as a lotion, emulsion, gel, cream, ointment, etc., skin cosmetics, quasi drugs for external use, Applicable to external medicines. Moreover, the usage-amount of the skin external preparation composition of this embodiment can be suitably set according to the dosage form.

  The skin external preparation composition of the present invention will be described more specifically with reference to the following examples. Note that the present invention is not limited to this.

Example 1
With the composition shown in Table 1, a skin external preparation composition was produced by a conventional method.

  Of these, Toray Dow Corning silicone SF8452C was used as the aminoethylaminopropylsiloxane / dimethylsiloxane copolymer. Further, FMBBLIN HC / 25 manufactured by Nikko Chemicals Co., Ltd. was used for perfluoropolyether, and PVP-K30W manufactured by Nippon Shokubai Co., Ltd. was used as polyvinylpyrrolidone.

  First, about an Example, the rough hand prevention effect, stickiness, and smell were examined about rough hand prevention, stickiness, and smell by use of about 1000 people for 2 to 3 weeks, respectively. The results are shown in Tables 2-4.

  As described above, the example has the effect of preventing rough hand, and the result is that there are very many cases where the feeling of use (stickiness, smell) does not matter.

  Next, the skin external preparation composition of the example was compared with a conventional skin external preparation (comparative example) by six panelists regarding the feeling of use (stickiness, smell) when applied to the skin.

  As a comparative example, a skin external preparation (boulder skin care (registered trademark), distributor Cosmo Project Co., Ltd.) that forms a commercially available film containing PVP was used. Containing components of the comparative example are water, dimethicone, stearic acid, glycerin, PVP, tri (capryl / capric acid), glyceryl, TEA, aloe vera extract 1, cetanol, cetearyl alcohol, ceteares 20, EDTA 4 Na, tocopherol acetate , Methyl paraben, propyl paraben, LGP (isobutane, propane). The results are shown in Table 5.

  From the results shown in Table 5, it is understood that both the stickiness and smell are weaker in the examples than in the comparative examples, and the usability is superior to the conventional skin external preparation.

  Then, about the film formed by an Example, permeation | transmission of bacteria and fungi was examined in Kyoto microbe research laboratory.

  1 g (ml) of an example was applied so as to cover a sterilized filter paper that was left on the medium, and a film was formed on the filter paper. Subsequently, a bacterial solution prepared with 1/500 ordinary bouillon was dropped on the coating, and the number of bacteria passing through the filter paper was measured. In addition, as a control, a bacterial solution was dripped onto untreated sterile filter paper, and a commercially available hand cream (Nivea (registered trademark) Nivea Kao Co., Ltd.) was applied to the filter paper in the same amount as in the examples, and the bacterial solution was applied to this. What was dripped and what apply | coated the above-mentioned comparative example to the filter paper by the same quantity as an Example and dripped the fungus | bacterial solution to this were used. Among these, the components of hand cream are as follows: water, mineral oil, petrolatum, glycerin, hydrogenated polyisoptene, cyclomethicone, microcrystalline wax, lanolin alcohol, paraffin, squalane, jojoba oil, decyl oleate, octyldodeca Nord, Al distearate, Mg stearate, Mg sulfate, citric acid, benzoic acid Na, fragrance.

  The bacteria are E. coli, St. aureus, Ps. Aeruginosa, Methicillin resistant Staphylococcus aureus (MRSA), and dermatophytes. Trichophyton mentagrophytes were used.

  Table 6 shows the results regarding bacteria and fungi permeation of filter paper.

  As shown in Table 6, when the skin external preparation composition of the example was applied, bacteria and fungi did not permeate the filter paper even after 1 hour and 4 hours after the bacteria were dropped, and were detected. There wasn't. That is, it was confirmed that these films can be largely suppressed by the film formed by the application of the example. On the other hand, in the comparative example, although relatively large ringworm bacteria were not permeated, permeation was confirmed for all other bacteria. In addition, when nothing was applied and when hand cream was applied, it was confirmed that bacteria and fungi were permeated through the filter paper.

Claims (4)

A skin external preparation composition capable of forming a film on the skin,
A skin external preparation composition comprising an aminoethylaminopropylsiloxane / dimethylsiloxane copolymer, perfluoropolyether, and polyvinylpyrrolidone.   The skin external preparation composition according to claim 1, wherein the aminoethylaminopropylsiloxane / dimethylsiloxane copolymer is 0.01 to 20.0% by mass.   The skin external preparation composition according to claim 1 or 2, wherein the perfluoropolyether is 0.01 to 10.0% by mass.   The external preparation composition for skin according to any one of claims 1 to 3, wherein the polyvinyl pyrrolidone is 0.01 to 10.0% by mass.