JP2012097013A - Blood circulation promoting aerosol composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an aerosol composition which can easily be used, has a good state of foams formed and no irritation when applied to the skin, and exhibits an excellent blood circulation promoting effect on the applied site while the good foam condition is maintained.SOLUTION: The aerosol composition is obtained by enclosing a stock solution including water, a hydrophilic surface active agent, a thickening agent, and an oily component and carbon dioxide in a pressure container having an aerosol valve and a nozzle. The foams of the aerosol composition formed by the injection from the pressure container are in a good state of foams and have no irritation when applied to the skin, and although the foams in contact with the skin begin to disappear within 20 seconds after the application to the skin, the state of foams is maintained at least one minute to exhibit an excellent blood circulation promoting effect on the applied site while the state of foams is maintained.

Description

  The present invention relates to an aerosol composition containing carbon dioxide, and more particularly to an aerosol composition that exhibits a blood circulation promoting effect by adding carbon dioxide.

  Conventionally, many proposals using the blood circulation promoting action of carbon dioxide have been made. For example, in Patent Document 1, a sheet material for body patch, in which a sheet-like patch is sealed together with carbon dioxide in a carbon dioxide-poor packaging pillow, the liquid constituting the sheet-like patch or By adjusting the amount of dissolved carbon dioxide and pH of the gel, and the packing ratio to the packaging pillow, it prevents the volatilization of carbon dioxide during storage and gives blood circulation promoting effects to the skin while suppressing the volatilization of carbon dioxide during use. Body sheet materials have been proposed. However, it is quite difficult to actually manufacture this body-applied sheet material.

  Many aerosol compositions containing carbon dioxide have also been proposed. Patent Document 2 proposes an aerosol composition containing a blood circulation promoter containing a blood circulation promoter, Patent Document 3 an aqueous cosmetic, and Patent Document 4 a polyalcohol blended with carbon dioxide having vasodilatory action. However, skin flushing associated with vasodilation when applied to the skin has not been confirmed. Further, in Patent Document 4, there is also a proposal for increasing the viscosity of the cosmetic material to increase the carbon dioxide gas persistence, but when the cosmetic material has a high viscosity, a double-structure aerosol container is used. There is also a problem that it is necessary and the cost becomes high.

  In addition, Patent Document 5 proposes an aerosol composition in which carbon dioxide gas persistence is improved by setting a specific ratio of a specific nonionic surfactant, a low-viscosity oil, ethanol, and water, but is essential. In addition to containing 20% or more of ethanol as a component, strong irritation is felt when applied to the skin for a long time, and skin flushing associated with vasodilation has not been confirmed. Patent Document 6 proposes an aerosol composition composed of a lipophilic surfactant, an oil component, an emulsified stock solution composed of water and a compressed gas containing carbon dioxide gas, but the foam formed from this composition is hard, so that Even if foam is applied to the skin, the carbon dioxide gas hardly penetrates into the skin, and the blood circulation promotion effect by the carbon dioxide gas cannot be obtained. In Patent Documents 7 and 8, a foamy skin coating agent is proposed in which carbon dioxide gas is allowed to act on the skin for a long period of time to obtain skin flushing and blood circulation promoting effects, but the essential component is selected from 3 to 5 carbon atoms. Since hydrocarbons are included, the skin irritation when foam formed from this foamy skin coating agent is applied to the skin is strong, and the above hydrocarbons are not blended and only carbon dioxide is blended. In the comparative example (Comparative Example 2 in Patent Document 7 and Comparative Example 1 in Patent Document 8), foam was formed but was not stable on the skin.

JP 2005-170937 A Japanese Examined Patent Publication No. 63-47684 Japanese Patent Publication No. 3-14284 JP-A-11-171755 Japanese Patent No. 3944124 Japanese Patent No. 4384767 JP 2009-269914 A Japanese Patent No. 3929936

  In view of this, the present invention can be used easily, and the state of the foam formed is good, there is no irritation to the skin when applied to the skin, and while the good foam state is maintained, It is an object of the present invention to provide a blood circulation promoting aerosol composition that exhibits an excellent blood circulation promoting effect. More desirably, it is intended to provide a blood circulation promoting aerosol composition whose blood circulation promoting effect can be easily visually recognized such as skin flushing.

  In order to solve the above-mentioned problems, the invention according to claim 1 of the present application is provided with an aerosol valve and a nozzle for water, a hydrophilic surfactant, a thickener, a stock solution containing an oil component, and carbon dioxide. In the aerosol composition sealed in a pressure vessel, after the foam formed by spraying from the pressure vessel is applied to the skin, the bubbles coming into contact with the skin within 20 seconds start to disappear, and for at least 1 minute Is for maintaining a foam state, and provides a blood circulation promoting aerosol composition characterized by exerting a blood circulation promoting effect on an application site while the foam state is maintained.

  In the invention according to claim 2 of the present application, the hydrophilic surfactant has an HLB of 10 to 19, and the hydrophilic surfactant content in the stock solution is 0.1 to 15% by weight. 2. The blood circulation promotion according to claim 1, wherein the oil component content in the stock solution is 3 to 30 wt%, and the carbon dioxide gas content in the aerosol composition is 500 to 5000 ppm. An aerosol composition is provided.

  The invention according to claim 3 of the present application provides the blood circulation promoting aerosol composition according to claim 2, wherein the propellant of the aerosol composition is composed of only the carbon dioxide gas. .

  The invention according to claim 4 of the present application is characterized in that the viscosity of the stock solution is 50 to 500 mPa · s at 20 ° C., and the blood circulation promoting aerosol composition according to any one of claims 1 to 3 I will provide a.

  The invention of the present application includes a stock solution containing water, a hydrophilic surfactant, a thickener, an oil component, and carbon dioxide gas in a pressure-resistant container equipped with an aerosol valve and a nozzle. Forms good foam, there is no irritation to the skin when the foam is applied to the skin, and the foam containing carbon dioxide gas is maintained for at least 1 minute after application, while the foam state is maintained at the application site In contrast, the present invention has been able to provide a blood circulation promoting aerosol composition that exhibits an excellent blood circulation promoting effect of carbon dioxide.

  Hereinafter, the blood circulation promoting aerosol composition according to the present invention will be described.

  The blood circulation promoting aerosol composition according to the present invention is a composition in which water, a hydrophilic surfactant, a thickener, a stock solution containing an oil component, and carbon dioxide gas are enclosed in a pressure-resistant container having an aerosol valve and a nozzle. It is a thing. Hereinafter, a stock solution containing water, a hydrophilic surfactant, a thickener, and an oil component is referred to as an aqueous stock solution.

  The blood circulation promoting aerosol composition according to the present invention contains water. The water is not particularly limited as long as it is usually used in an aerosol composition, and examples thereof include purified water, ion exchange water, and distilled water.

A hydrophilic surfactant is blended in the blood circulation promoting aerosol composition according to the present invention. This hydrophilic surfactant emulsifies the oil component described later in the water.
Examples of the hydrophilic surfactant include polyglycerin fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene sorbite fatty acid ester, Examples thereof include oxyethylene glycerin fatty acid ester, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene lanolin alcohol, and the like. The hydrophilic / new oil balance (hereinafter referred to as HLB) is 10 to 19, preferably It is in the range of 12-19, more preferably 14-18. When the HLB is less than 10, a good foam state is not formed. These hydrophilic surfactants can be used alone or in combination of two or more. Further, a hydrophilic surfactant having a relatively high HLB and a hydrophilic surfactant having a relatively low HLB may be mixed and used.

  Moreover, in order to fully emulsify the oil component mentioned later, the content of these hydrophilic surfactants is preferably in the range of 0.1 to 15% by weight with respect to the aqueous stock solution, and 2 to 2 with respect to the aqueous stock solution. A range of 10% by weight is more preferred.

The blood circulation promoting aerosol composition according to the present invention is mixed with a thickener for adjusting the viscosity of the aqueous stock solution.
The thickener is not particularly limited, but for example, polyacrylic resin, polyvinyl resin, hydroxyethyl cellulose, hydroxypropyl cellulose, sodium alginate, propylene glycol alginate, carboxymethyl cellulose ester, sodium carboxymethyl cellulose, sodium starch phosphate , Starch glycolate, methylcellulose, sodium polyacrylate, cellulose ester, alginic acid, casein, guar gum, gluten, starch and the like. These thickeners can be used alone or in combination of two or more.

  The viscosity of the aqueous stock solution at 20 ° C. is preferably in the range of 50 to 500 mPa · s, more preferably in the range of 200 to 300 mPa · s. When the viscosity exceeds 500 mPa · s, the contents attached in the container are not discharged to the end, and the remaining amount increases. Moreover, when the viscosity is less than 50 mPa · s, the foam drips down when foam formed by spraying from a pressure-resistant container equipped with an aerosol valve and a nozzle enclosing an aqueous stock solution and carbon dioxide gas is applied to the skin. The foam does not retain carbon dioxide without maintaining a good foam state.

The blood circulation promoting aerosol composition according to the present invention contains an oil component. This oil component increases the emollient property of the skin, improves the feeling of use, and imparts gloss.
This oil component refers to a liquid component that does not dissolve in water, and is not particularly limited, but includes hydrocarbons such as normal paraffin, isoparaffin, liquid paraffin, squalane, petrolatum, isopropyl myristate, cetyl octanoate, isopropyl palmitate, Ester oils such as myristyl myristate, isocetyl stearate, cetyl lactate, silicone oils such as dimethyl silicone and cyclic silicone, oils such as olive oil, rapeseed oil, castor oil, camellia oil, linseed oil, jojoba oil, lauryl alcohol, cetyl alcohol , Stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol and other linear alcohols, monostearyl glycerin ether, lanolin alcohol, isostearyl alcohol, octyldede And higher alcohols such as branched chain alcohols such as Nord can be exemplified. Further, the content of these oil components is preferably in the range of 3 to 30% by weight, more preferably in the range of 5 to 15% by weight with respect to the aqueous stock solution.

  The aqueous stock solution constituting the aerosol composition according to the present invention comprises water, a hydrophilic surfactant, a thickener, and an oil component, but in the range not departing from the object of the present invention, in addition to the above components, for example, , Moisturizers such as glycerin and sorbit liquids, alcohols such as ethanol and isopropanol, fragrances, antioxidants such as dl-α-tocopherol, antiseptic disinfectants such as p-hydroxybenzoic acid esters, whitening agents and skin roughening agents It is possible to add other drugs.

  As described above, the blood circulation promoting aerosol composition according to the present invention is a composition in which an aqueous stock solution and carbon dioxide gas are sealed in a pressure-resistant container equipped with an aerosol valve and a nozzle. Carbon dioxide gas is contained in the present invention. It is an essential ingredient. Compressed air, such as compressed air, nitrogen, and oxygen, usually used as aerosols for propellants, have low solubility in aqueous concentrates, so foam formation is weak and good foam is not formed, and blood circulation promotion effects are not obtained. . Similarly, a liquefied gas such as LPG (liquefied petroleum gas), which is usually used for aerosol products as a propellant, not only provides a blood circulation promoting effect but also irritate the skin.

  Further, the carbon dioxide content in the aerosol composition is preferably in the range of 500 to 5000 ppm in order to function as a propellant and to exert an excellent blood circulation promoting effect. Regarding the aerosol product, in the aerosol product using only carbon dioxide, the content of the stock solution is 40 to 70% with respect to the full amount of the container. If the carbon dioxide dissolved in the aqueous stock solution used in the present invention is 500 ppm, the pressure in the container is 0.2 MPa at 35 ° C., and if it is 5000 ppm, the pressure in the container is 0.98 MPa. The Japan Aerosol Association voluntary standards stipulate that aerosol products that use only compressed gas are not subject to the High Pressure Gas Safety Law if the pressure at 35 ° C. is less than 1.0 MPa. If the carbon dioxide content is less than 500 ppm, the pressure in the container at 35 ° C. will be less than 0.2 MPa, and the aerosol product cannot be used to the end, and if it exceeds 5000 ppm, the pressure in the container will be 1.0 MPa or more. Under the application of the High Pressure Gas Safety Law, it will not be an aerosol product. Therefore, the pressure of the pressure vessel described later is preferably in the range of 0.2 to less than 1.0 MPa at 35 ° C., and more preferably in the range of 0.4 to 0.8 MPa. Moreover, in order to exhibit the blood circulation promotion effect by a carbon dioxide gas, pH of an aerosol composition should just be 7.0 or less in the state which a carbon dioxide gas dissolved, and since it is a product used for skin, it is pH3.0. It is preferably in the range of -7.0, more preferably in the range of pH 4.0-6.0. In order to adjust the pH within the above range, a pH adjusting agent such as sodium citrate may be blended. In addition to carbon dioxide, LPG (liquefied petroleum gas), which is usually used in aerosol products as a propellant, may be used as a propellant as long as it does not irritate the skin and does not cause harmful effects in the present invention. Compressed gas such as compressed air, nitrogen, and oxygen may also be used as a propellant in addition to carbon dioxide gas without departing from the object of the present invention.

  The aqueous stock solution and the carbon dioxide gas are enclosed in a pressure-resistant container equipped with an aerosol valve and a nozzle. There is no particular limitation on the sealing method, and for example, a method in which each component of the aqueous stock solution is stirred and mixed, emulsified and adjusted, then filled in a pressure resistant container, and further compressed carbon dioxide gas is sealed in the pressure resistant container is adopted. be able to. In addition, the pressure vessel to be used is not limited as long as it can withstand the internal pressure of the enclosed carbon dioxide gas and can discharge the enclosed contents in the form of foam. In addition to metal such as aluminum and tinplate, polyacetal, polycarbonate, etc. A container such as a synthetic resin can be used. Furthermore, there are no particular restrictions on the nozzle diameter and nozzle length that serve as the discharge port, and it is possible to use various sizes and lengths suitable for allowing the enclosed contents to be discharged in the form of bubbles. .

  The blood circulation-promoting aerosol composition according to the present invention forms a good foam, and the foam in the portion in contact with the skin starts to disappear within 20 seconds after being applied to the skin, but the good foam state formed is at least 1 minute. Maintain. Therefore, the carbon dioxide gas contained in the formed foam is also held for at least 1 minute, and exerts a blood circulation promoting effect on the skin applied during that time. Moreover, the blood flow improvement effect of skin can also be expected by continuously using the blood circulation promoting aerosol composition according to the present invention on the skin.

  The blood circulation promoting aerosol composition according to the present invention includes, for example, basic cosmetics such as lotion, milky lotion, cosmetic liquid and cleansing agent, shampoo and conditioner, cosmetics for hair and scalp such as hair restorer, and body care such as body soap. It can be used as cosmetics.

  Hereinafter, the present invention will be described in detail with reference to examples, but the present invention is not limited to these examples.

(Examples 1-3)
Each component shown in Table 1 is stirred and mixed, emulsified to prepare an aqueous stock solution, filled into a pressure-resistant container equipped with an aerosol valve and a nozzle, and then filled with carbon dioxide at the blending ratio shown in Table 1 for blood circulation. An accelerated aerosol composition was obtained. The obtained blood circulation promoting aerosol composition was evaluated for foam stability, skin irritation, and flushing by the following methods.

(Viscosity measurement)
A B-type viscometer (type BM) (manufactured by Tokyo Keiki Co., Ltd.) was used to measure the viscosity of the aqueous stock solution. The measurement temperature was 20 ° C. Using two rotors, the viscosity was measured 60 seconds after the start of measurement at a rotor rotation speed of 30 rpm.
(PH measurement)
PHMETER (M-13 type) (manufactured by HORIBA) was used for pH measurement of the blood circulation promoting aerosol composition according to the present invention. The measurement temperature was 20 ° C.

(Evaluation methods)
The following tests were conducted and evaluated by 20 men and women in their 20s and 50s.
(1) Foam stability The foam of each sample formed by spraying from a pressure-resistant container was applied to the skin so as to have a diameter of 3 cmφ, and allowed to stand at room temperature (23-27 ° C.) for 2 minutes to evaluate the state of the foam. .
A: Bubbles are formed, and the bubble state is maintained for 2 minutes. O: Bubbles are formed, but they are dripped for 1 minute or more and less than 2 minutes. Δ: Bubbles are formed, but they are dripped in less than 1 minute. No foam is formed (2) Skin irritation The foam of each sample formed by spraying from a pressure-resistant container is applied on the skin so as to have a diameter of 3 cmφ, and left for 2 minutes to wipe off. Thereafter, a monitor survey was conducted for skin irritation.
A: 18 or more responded that there was no irritation.
○: 14 to 17 people answered that there was no irritation.
Δ: 10 to 13 persons answered that there was no irritation.
×: Nine or less responded that there was no irritation.
(3) Skin flushing Apply the foam of each sample formed by spraying from the pressure-resistant container so that it becomes 3 cmφ on the skin, leave it for 2 minutes, and visually observe the skin condition (skin flushing) after wiping off did. Blood circulation promotion effect was evaluated by skin flushing.
◎: 18 or more people observed flushing ○: 14-17 people observed flushing △: 10-13 people observed flushing ×: 9 or less people observed flushing

(Comparative Examples 1-5)
For comparison between Example 1 and Example 3, in addition to carbon dioxide, LPG (liquefied petroleum gas) was added and blended, thickener was not blended, ethanol was blended, oil components and What increased / decreased the amount of hydrophilic surfactant was prepared by the method similar to the said Example 1- Example 3, and this was made into Comparative Example 1- Comparative Example 5. The components and test results of these Comparative Examples 1 to 5 are shown in Table 1.

As shown in Table 1, Examples 1 to 3 have good foam stability at room temperature (23 to 27 ° C.), and skin flushing was observed, confirming the blood circulation promoting effect by carbon dioxide. I was able to. Further, no skin irritation was observed. In Example 1 and Example 2, there is a difference in the blending ratio of the oil component to the aqueous stock solution, but good results were obtained by blending an appropriate amount of the hydrophilic surfactant with respect to the oil component.
In Comparative Example 1 in which LPG (liquefied petroleum gas) was added in addition to the carbon dioxide gas of Example 1, the foam stability at room temperature (23 to 27 ° C.) was good, but no skin flushing was observed, Skin irritation by LPG was observed in more than half of the subjects. Moreover, the comparative example 3 which mix | blended ethanol more than half in the aqueous | water-based stock solution, and did not mix | blend a thickener does not form a foam, the presence or absence of a thickener, an oil component, and the quantity of hydrophilic surfactant. In Comparative Example 2 and Comparative Examples 4 to 5 which were increased or decreased, although the skin irritation was not observed, the foam stability was poor and skin flushing was not observed.
Therefore, an aerosol composition in which water, a hydrophilic surfactant, a thickener, an aqueous stock solution containing an oil component, and carbon dioxide gas are sealed in a pressure-resistant container equipped with an aerosol valve and a nozzle have a good foam state. The foam containing carbon dioxide gas at the point of contact with the skin starts to disappear within 20 seconds after being applied to the skin without any irritation to the skin, but the foam state is maintained for at least 1 minute. It was confirmed that an excellent blood circulation promoting effect was obtained by the penetration of carbon dioxide into the skin.

Claims (4)

In an aerosol composition in which water, a hydrophilic surfactant, a thickener, a stock solution containing an oil component, and carbon dioxide gas are sealed in a pressure-resistant container equipped with an aerosol valve and a nozzle,
After the foam formed by spraying from the pressure vessel is applied to the skin, the foam at the point of contact with the skin within 20 seconds begins to disappear, and the foam state is maintained for at least 1 minute.
A blood circulation promoting aerosol composition characterized by exerting a blood circulation promoting effect on an application site while the foam state is maintained. The HLB of the hydrophilic surfactant is 10 to 19, and the hydrophilic surfactant content in the stock solution is 0.1 to 15% by weight;
The oil component content in the stock solution is 3 to 30% by weight,
The blood circulation promoting aerosol composition according to claim 1, wherein the carbon dioxide gas content in the aerosol composition is 500 to 5000 ppm.   The blood circulation promoting aerosol composition according to claim 2, wherein the propellant of the aerosol composition is composed only of the carbon dioxide gas.   The blood circulation promoting aerosol composition according to any one of claims 1 to 3, wherein the stock solution has a viscosity of 50 to 500 mPa · s at 20 ° C.