JP2019104924A - Anti-microbial cleaning composition - Google Patents

Abstract

To provide a cleaning composition that provides desired performance in both cleaning and anti-microbial aspects.SOLUTION: An anti-microbial cleaning composition comprises: a) by weight of a cleaning composition, from about 0.001% to about 3% of a nonionic anti-microbial agent; and b) by weight of a composition, from 0.1% to 3% of a soil dispersant comprising an alkylene amine backbone and a side chain bonded to the nitrogen atom of the alkylene amine backbone. The side chain is the following formula (I): -(EO)b(PO). In the formula (I), b ranges from 3 to 60, and c ranges from 0 to 60.SELECTED DRAWING: None

Description

  The present invention relates to antimicrobial cleaning compositions.

  Various techniques have been utilized to improve the cleaning performance of cleaning products such as laundry detergents or hair shampoos. For example, certain polymers (eg, polyethylene imine branched with ethyleneoxy side chains) can function as a soil dispersant when incorporated into a laundry detergent composition. These polymers facilitate soil removal during the wash cycle, stabilize the separated soil in the wash solution and prevent redeposition on the fabric. Thus, such soil dispersants significantly improve the cleaning performance of the product.

  Also, cleaning compositions have been developed to address the user's need for antimicrobial efficacy in addition to the original intended function (i.e., the cleaning function). For example, antimicrobial laundry detergent products are desired by users because they provide an antimicrobial effect on the fabric while cleaning the fabric. At present, the use of various antibacterial agents is known for the formulation of cleansing to provide antibacterial action. When attached to the site to be treated, such an antibacterial agent destroys the bacterial envelope and kills the bacteria, or denatures the bacterial envelope to prevent the growth or reproduction of the bacteria, whereby the antibacterial effect is achieved. Bring In order to provide the desired antimicrobial action on the treated area (e.g., the treated fabric), a sufficient amount of the antimicrobial agent needs to adhere to the area during the wash cycle. However, the adhesion of the antimicrobial agent on the treated area is negatively affected by the above-mentioned soil dispersants added to address soil redeposition. In other words, it is difficult in the art to achieve both the desired cleaning performance and the antimicrobial effect for the cleaning composition.

  Thus, there is a need for cleaning compositions that provide the desired performance in both cleaning and antimicrobial terms.

  It is a further advantage of the present invention to provide a stable liquid antimicrobial cleaning composition.

The present invention relates to an antimicrobial cleaning composition, which comprises:
a) 0.001% to 3% non-ionic antimicrobial agent with respect to the weight of the cleaning composition,
b) a soil dispersant comprising from 0.1% to 3% by weight of the composition of an alkyleneamine main chain and a side chain attached to a nitrogen atom of the alkyleneamine main chain, said side chain comprising , Formula (I).
-(EO) _b (PO) _c (I)
In the formula, b is in the range of 3 to 60, and c is in the range of 0 to 60.

  In the present invention, it has surprisingly been found that the use of certain antimicrobial agents and soil dispersants at certain concentrations minimizes the negative impact on the adherence of the antimicrobial agent caused by the soil dispersants. The At the same time, the incorporated soil dispersant also improves the cleaning performance. Thus, a cleaning composition having both good cleaning and antimicrobial performance is obtained. Without being bound by theory, it is believed that when the soil dispersant is present at a relatively low concentration, the antimicrobial agent is present in the wash solution without being trapped by the soil dispersant. As such, such free antimicrobial agents can be effectively deposited on the treated fabric, resulting in the desired antimicrobial action.

Definitions As used herein, the term "cleaning composition" refers to the cleaning or treating of fabrics, hard or soft surfaces, skin, hair or any other surface in the hair or fabric care, home care, skin care and hair care fields. Refers to the composition. Examples of cleaning compositions include laundry detergents, laundry detergent additives, softeners, carpet cleaners, floor cleaners, bathroom cleaners, toilet cleaners, sink cleaners, dishwashing cleaners, air care, car care, skin These include, but are not limited to moisturizers, skin cleansers, skin treatment emulsions, shaving creams, hair shampoos, hair conditioners. The cleaning composition is preferably a liquid cleaning composition, more preferably a liquid laundry detergent composition, a liquid softener composition, a liquid dishwashing detergent composition or a hair shampoo, still more preferably a liquid laundry detergent composition It is a thing. As used herein, the term "liquid cleaning composition" refers to a composition that is in a form selected from the group consisting of pourable liquids, gels, creams and combinations thereof. The liquid cleaning composition may be aqueous or non-aqueous, anisotropic, isotropic, or a combination thereof.

  As used herein, the term "antimicrobial agent" is a chemical compound whose main predetermined function is the killing of bacteria or the prevention of bacterial growth or reproduction. Conventional antimicrobial agents include cationic antimicrobial agents (eg, certain ammonium chlorides), nonionic antimicrobial agents, and the like. Preferred diphenyl ether compounds for use in the present invention are non-ionic antimicrobial agents.

  As used herein, the term "situs" includes fabrics, paper products, clothes, hard surfaces, hair and skin.

  As used herein, the term "washing solution" refers to the usual volume of aqueous solution used in one wash wash cycle, preferably 1 L to 50 L, or 1 L to 20 L by hand, 20 L by washing with a washing machine ~ 50L.

  As used herein, the term "alkyl" means a hydrocarbyl moiety that is branched or unbranched, substituted or unsubstituted. The term "alkyl" includes the alkyl portion of an acyl group.

  As used herein, when the composition is "substantially free" of a particular component, the composition is less than a trace amount, or less than 0.1% by weight of the composition, or 0. 0%. It is meant to contain less than 01% by weight, or alternatively 0.001% by weight of certain components.

  As used herein, articles including "a" and "an" are understood to mean one or more of the claims or set forth as used in the claims.

  As used herein, the terms "comprise, comprises, comprising", "includes, includes, including", "contains, contains, containing" are non-limiting. That is, other steps and other ingredients that do not affect the end result can be added. The above terms include the terms "consisting of and" consisting essentially of.

Antimicrobial Cleaning Composition The antimicrobial cleaning composition of the present invention comprises 0.001% to 3% of a nonionic antibacterial agent, 0.1% to 3% of an alkyleneamine main chain and 0.001% to 3% of the weight of the composition. Included are soil dispersants that include side chains attached to the nitrogen atom of the alkylene amine backbone. The side chain consists of formula (I).
-(EO) _b (PO) _c (I)
In the formula, b is in the range of 3 to 60, and c is in the range of 0 to 60.

  Preferably, the non-ionic antimicrobial agent is present in the cleaning detergent composition from 0.01% to 1%, more preferably 0.03% to 0.5%, by weight of the composition. The soil dispersant is preferably present at 0.2% to 2%, more preferably 0.3% to 1.5%, relative to the weight of the composition.

  The cleaning composition can deliver the antimicrobial agent in the cleaning solution preferably at a concentration of 0.01 ppm to 5 ppm, more preferably 0.05 ppm to 3 ppm, more preferably 0.1 ppm to 1 ppm.

  The laundry detergent compositions herein provide an antimicrobial effect against both gram positive bacteria (eg, Staphylococcus aureus) and gram negative bacteria (eg, Klebsiella pneumoniae). The composition preferably provides a residual antimicrobial effect to the fabric treated with the composition, ie, the non-ionic antimicrobial agent in the composition is deposited on the fabric during the wash cycle and then deposited (ie, remains) 2.) The antimicrobial agent prevents bacteria from growing on the fabric during drying, storage or wearing. In one embodiment, the laundry detergent composition has a log reduction of at least 2.2, preferably 2 as compared to treated and non-treated fabrics, for both gram positive and gram negative bacteria. It results in bacteriostatic activity values with a log reduction of .5. Preferably, the composition has a log reduction of at least 2.2, preferably against Staphylococcus aureus and / or Klebsiella pneumoniae, after a contact time of 10 minutes in a 2069 ppm aqueous solution as defined in JIS L 1902 method (described below). Results in a 2.5 log reduction. More preferably, the composition provides at least a 3.0 log reduction, preferably a 3.5 log reduction, for S. aureus. It should be noted that fabrics, particularly those worn, are required to have antimicrobial activity, particularly against S. aureus, as S. aureus is frequently found on human skin.

  The laundry detergent compositions herein may be acidic or alkaline or pH neutral, depending on the ingredients to be incorporated into the composition. The pH range of the laundry detergent composition is preferably 6 to 12, more preferably 7 to 11, and even more preferably 8 to 10.

  In the case of liquid cleaning composition practice, it may have any suitable viscosity, depending on factors such as the ingredients formulated and the purpose of the composition. In one embodiment, the composition has a high shear viscosity value of 200 to 3,000 cP, alternatively 300 to 2,000 cP, alternatively 500 to 1,000 cP, at a shear rate of 20 / sec and a temperature of 21 ° C. The low shear viscosity value at a shear rate of 1 / s and a temperature of 21 ° C. is 500 to 100,000 cP, alternatively 1000 to 10,000 cP, alternatively 1,500 to 5,000 cP.

Nonionic Antimicrobial Agent The antimicrobial agent of the present invention is nonionic. In the present invention, it has been found that the antimicrobial agent of the present invention, due to its non-ionic nature, results in a stable antimicrobial cleaning composition, in particular in a liquid composition. In contrast, conventional cationic antimicrobials are generally not compatible with the anionic surfactant present in the cleaning composition.

  The antimicrobial agent is preferably diphenyl ether, more preferably hydroxyl diphenyl ether. The nonionic antimicrobial agent herein may be either halogenated or non-halogenated, but is preferably a halogenated antimicrobial agent. Diphenyl ethers suitable for use herein are described in column 1, line 54 to column 5, line 12 of US Pat. No. 7,041,631 (B), which is incorporated by reference.

  In one embodiment, the non-ionic antimicrobial agent is a hydroxyl diphenyl ether of formula (II).

各Ｙは、独立して、塩素、臭素又はフッ素から選択され、好ましくは塩素又は臭素であり、より好ましくは塩素であり、
各Ｚは、独立して、ＳＯ_２Ｈ、ＮＯ_２又はＣ_１〜Ｃ_４アルキルから選択され、
ｒは、０、１、２又は３であり、好ましくは１又は２であり、
ｏは、０、１、２又は３であり、好ましくは０、１又は２であり、
ｐは、０、１又は２であり、好ましくは０であり、
ｍは、１又は２であり、好ましくは１であり、
ｎは、０又は１であり、好ましくは０である。

Each Y is independently selected from chlorine, bromine or fluorine, preferably chlorine or bromine, more preferably chlorine
Each Z is independently selected from SO ₂ H, NO ₂ or C ₁ -C ₄ alkyl,
r is 0, 1, 2 or 3, preferably 1 or 2;
o is 0, 1, 2 or 3, preferably 0, 1 or 2;
p is 0, 1 or 2, preferably 0,
m is 1 or 2, preferably 1.
n is 0 or 1, preferably 0.

  In the above definition of formula (II), 0 means absent. For example, when p is 0, Z in formula (II) is absent. Each Y or each Z may be the same or different. In one embodiment, o is 1, r is 2 and Y is chlorine or bromine. In this embodiment, one chlorine atom is bonded to one benzene ring, and a bromine atom and another chlorine atom are bonded to the other benzene ring, or a bromine atom is bonded to one benzene ring, One chlorine atom may be bonded to the other benzene ring.

  Preferably, the non-ionic antimicrobial agent herein is 4-4'-dichloro-2-hydroxydiphenyl ether ("Diclosan"), 2,4,4'-trichloro-2'-hydroxydiphenyl ether ("Triclosan") And combinations thereof. Most preferably, the antimicrobial agent is 4-4'-dichloro-2-hydroxydiphenylether, which is commercially available from BASF under the tradename Tinosan® HP 100.

  In addition to diphenyl ether, other anti-microbial agents may be present, provided they are present at concentrations which do not cause instability in the formulation. Such useful further antimicrobial agents include chelating agents, which are particularly useful in reducing the resistance of gram negative bacteria in hard water. An acid biocide may be present.

Soil Dispersant The soil dispersant of the present invention comprises an alkyleneamine backbone and a side chain attached to the nitrogen atom of the alkyleneamine backbone, the side chain comprising formula (I).
-(EO) _b (PO) _c (I)
Where b represents the number of ethyleneoxy ("EO") units linked to the nitrogen atom of the alkyleneamine backbone and is in the range of 3 to 60, c is propyleneoxy (" PO ") represents the number of units (if any) and is in the range of 0-60. Without being bound by theory, it is believed that the soil dispersant herein is intended to separate soil from the treated fabric by hydrophilic EO chains and to prevent reattachment of the soil on the fabric. Be

  The backbone used for the soil dispersants herein may be any suitable alkylene amine (e.g., ethylene amine, propylene amine), including quaternized amines and non-quaternized amines. The backbone may include a single alkylene amine or, in the case of a polymer, multiple alkylene amines (eg, polyalkylene imines). When a plurality of alkylene amines are contained in the main chain, the side chain of the formula (I) is bonded to at least one nitrogen atom of the main chain, preferably, the side chains of the formula (I) Each join. That is, there are a plurality of side chains of formula (I) in the soil dispersant molecule. When the side chain of formula (I) is attached to a nitrogen atom, one or two formulas (I will be used depending on whether the nitrogen atom is at an internal position or at an end position of the main chain. Side chains can be attached. The number of side chains in the soil dispersant molecule may be from one to several hundred depending on factors such as the size of the main chain, the number of available nitrogen atoms in the main chain, and the like. For example, in the case of the polyalkyleneimine implementation, the number of side chains may be from one to several hundred, preferably from 5 to 80, alternatively from 10 to 50.

Preferably, the soil dispersant herein is:
a) Side chains of the formula (I) bound to the nitrogen atoms of the polyethyleneimine (PEI) which is the main chain and the PEI main chain (preferably two linked respectively to two or more nitrogen atoms of the PEI main chain Or polyethyleneimine ethoxylate having a side chain of formula (I)
-(EO) _b (PO) _c (I)
(Wherein, b is in the range of 3 to 60 and c is in the range of 0 to 60)
b) Formula (III):

（式中、Ｒは、式（ＩＶ）：
−（ＥＯ）_ｎＲ^４ （ＩＶ）
のエチレンオキシ単位であり、式中、ｎは、３〜５０の範囲であり、Ｒ^４は、水素、アニオン性単位又はこれらの組み合わせであり、Ｑは、Ｃ_１〜Ｃ_８直鎖アルキル、Ｃ_３〜Ｃ_８分枝状アルキル、ベンジル及びこれらの混合物からなる群から独立して選択される四級化単位であり、Ｘは、水溶性アニオンである）の化合物、並びに
これらの組み合わせからなる群から選択される化合物を含む。

(Wherein R is a group of formula (IV):
-(EO) _n R ⁴ (IV)
Ethyleneoxy units, where n is in the range of 3 to 50, R ⁴ is hydrogen, an anionic unit or a combination thereof, Q is C ₁ -C ₈ straight chain alkyl, C _{3 to} C ₈ branched alkyl, benzyl and quaternized units independently selected from the group consisting of a mixture thereof, wherein X is a water-soluble anion), and a group consisting of a combination thereof And a compound selected from

Polyethyleneimine Ethoxylate In the case of polyethyleneimine ethoxylate, the PEI backbone may be either linear or cyclic or a combination thereof. The PEI backbone may also have more or less PEI branches. Generally, the PEI backbone described herein is modified as described below for units in which each nitrogen atom of the PEI chain is substituted, quaternized, oxidized or a combination thereof. The PEI backbone, except for the side chains prior to modification, has a number average molecular weight (Mw _n ) ranging from about 100 to about 100,000, preferably about 200 to about 10,000, more preferably 300 to about 3,000. Have.

  Without being bound by theory, it is believed that at representative wash conditions where the pH of the wash solution is around 8 the nitrogen atoms of the PEI backbone are partially protonated. Thus, during the wash cycle, the PEI backbone adheres to the soil (eg, clay) and penetrates imperfections such as crevices and crevices. Penetration of the PEI backbone, along with the hydrophilic ethyleneoxy chains extending outward from the soil surface, further enhances clay removal performance.

In formula (I),
-(EO) _b (PO) _c (I)
b represents the average number of EO units per nitrogen atom of the PEI backbone, and is in the range of 3 to 60, preferably 5 to 50, more preferably 15 to 35, and c is a nitrogen atom of the PEI backbone Represents the average number of PO units per and is in the range of 0-60.

  The polyethyleneimine ethoxylates herein can be divided into two sub-groups when c is 0 and when c is in the range 1 to 60, depending on the value of c in formula (I) .

  When c is taken to be 0, the compound has no PO unit. Compounds of this type and methods for their preparation are outlined in US Pat. No. 6,087,316. A preferred example of this type of soil dispersant is a polyethylene corresponding to formula (I) having a PEI backbone having a number average molecular weight of about 600 which has been ethoxylated to the extent of about 20 EO units per PEI nitrogen atom It is an imine.

  Alternatively, where c is from 1 to 60, the compound has one or more PO units. Because the PO units are hydrophobic, in combination with the hydrophilic EO chain, the soil dispersant becomes amphiphilic. The compounds herein can achieve balanced hydrophilic and hydrophobic properties by adjusting the number of EO units and PO units in the compound, thereby providing grease / oil, etc. The overall cleaning against surfactant sensitive stains is improved. In one embodiment, c is in the range of 5-40, preferably in the range of 10-25. Compounds of this type and methods for their preparation are outlined in US Pat. No. 8,097,579. A preferred example of this type of soil dispersant is a number of about 600 which has been ethoxylated to the extent of about 30 EO units per PEI nitrogen atom and propoxylated to the extent of about 5 PO units per PEI nitrogen atom It is a polyethyleneimine corresponding to formula (I) having a PEI main chain which is an average molecular weight.

  These PEI backbones can be prepared, for example, by polymerizing ethyleneimine in the presence of a catalyst such as carbon dioxide, sodium bisulfite, sulfuric acid, hydrogen peroxide, hydrochloric acid, acetic acid and the like. Specific methods for preparing these PEI backbones are described in U.S. Pat. Nos. 2,182,306 (Ulrich et al., Issued Dec. 5, 1939), 3,033,746 (Mayle et al., No. 2,208,095 (Esselmann et al., Issued on July 16, 1940), No. 2,806,839 (Crowther, issued on Sept. 17, 1957), and the same. No. 2,553,696 (Wilson, issued May 21, 1951). The PEI backbone is then modified by ethoxylation and optional propoxylation to obtain a polyethyleneimine ethoxylate.

Compounds of Formula (III) The compounds of formula (III) are zwitterionic hexamethylene diamines comprising a quaternized diamine backbone and a long EO chain. Such zwitterionic hexamethylene diamines and methods for their preparation are outlined in US Pat. No. 6,444,633. Without being bound by theory, the quaternized diamine backbone effectively adsorbs onto the clay platelets while the EO chains separate the clay and stabilize the separated clay from reattachment it is conceivable that.

  In formula (III),

Ｒは、式（ＩＶ）のエチレンオキシ単位であり、
−（ＥＯ）_ｎＲ^４ （ＩＶ）
式中、ｎは、ＥＯ単位の平均数を表し、３〜５０の範囲である。配合者が選択するＥＯ単位を形成するための方法に応じて、存在するＥＯ単位の範囲はより広くもなるし、より狭くもなる。好ましくは、ＥＯ単位の範囲は、プラス又はマイナス２単位、より好ましくはプラス又はマイナス１単位である。最も好ましくは、各Ｒ基は、同じ数のＥＯ単位を含む。添え字ｎは、好ましくは１０〜４０、より好ましくは１５〜３５である。ｎの好ましい値は、２４であり、
Ｒ^４は、水素、アニオン性単位又はこれらの組み合わせである。アニオン性単位の非限定的な例としては、−（ＣＨ_２）_ｐＣＯ_２Ｍ、−（ＣＨ_２）_ｑＳＯ_３Ｍ、−（ＣＨ_２）_ｑＣＨ（ＳＯ_２Ｍ）−ＣＨ_２ＳＯ_３Ｍ、−（ＣＨ_２）_ｑＣＨ（ＯＳＯ_２Ｍ）ＣＨ_２ＯＳＯ_３Ｍ、−（ＣＨ_２）_ｑＣＨ（ＳＯ_３Ｍ）ＣＨ_２ＳＯ_３Ｍ、−（ＣＨ_２）_ｐＰＯ_３Ｍ、−ＰＯ_３Ｍ及びこれらの混合物が挙げられ、式中、Ｍは、電荷平衡を満たすのに十分な量の水素又は水溶性カチオンである。好ましいアニオン性単位は、−（ＣＨ_２）_ｐＣＯ_２Ｍ又は−（ＣＨ_２）_ｑＳＯ_３Ｍ、より好ましくは−（ＣＨ_２）_ｑＳＯ_３Ｍである。添え字ｐ及びｑは、０〜６の整数である。双性イオン性ジアミンの凝集体サンプルを含む全てのＲ^４単位のうち、好ましくは、約８５％超、より好ましくは約９０％超、最も好ましくは約９５％超がアニオン性単位であるＲ^４単位を有する。配合者であれば、いくつかの分子がアニオン性単位で完全に末端保護されるのに対し、いくつかの分子は水素である２つのＲ^４単位を含み得ることを理解するであろう。しかしながら、最も好ましくは、存在する全てのＲ単位の約９５％超が、本明細書に記載した１つ以上のアニオン性単位で末端保護される。
Ｑは、Ｃ_１〜Ｃ_８直鎖アルキル、Ｃ_３〜Ｃ_８分枝状アルキル、ベンジル及びこれらの混合物からなる群から独立して選択される四級化単位であり、好ましくはメチル又はベンジルであり、最も好ましくはメチルであり、
Ｘは、電子的中性をもたらすのに十分な量の水溶性アニオンである。対イオンのＸは、かなりの程度で、四級化を行うために使用する単位に由来する。例えば、四級化剤に塩化メチルを用いる場合、塩素（塩化物イオン）が対イオンＸになる。臭化ベンジルが四級化剤である場合は、臭素（臭化物イオン）が主な対イオンになる。

R is an ethyleneoxy unit of formula (IV),
-(EO) _n R ⁴ (IV)
In formula, n represents the average number of EO units, and is the range of 3-50. Depending on the method for forming the EO units chosen by the formulator, the range of EO units present may be broader or narrower. Preferably, the range of EO units is plus or minus 2 units, more preferably plus or minus 1 unit. Most preferably, each R group contains the same number of EO units. The subscript n is preferably 10 to 40, more preferably 15 to 35. The preferred value of n is 24 and
R ⁴ is hydrogen, an anionic unit or a combination thereof. Nonlimiting examples of anionic _{units, - (CH 2) p CO} 2 M, - (CH 2) q SO 3 M, - (CH 2) q CH (SO 2 M) -CH 2 SO 3 M ,-(CH ₂ ) _q CH (OSO ₂ M) CH ₂ OSO ₃ M,-(CH ₂ ) _q CH (SO ₃ M) CH ₂ SO ₃ M,-(CH ₂ ) _p PO ₃ M, -PO ₃ And M and mixtures thereof, where M is a sufficient amount of hydrogen or water soluble cation to satisfy charge balance. Preferred anionic _{units, - (CH 2) p CO} 2 M or _{- (CH 2) q SO 3} M, more preferably - a _{(CH 2) q SO 3 M} . The subscripts p and q are integers of 0 to 6. Of all R ⁴ units comprising the zwitterionic diamine aggregate sample, preferably more than about 85%, more preferably more than about 90%, most preferably more than about 95% of the anionic units R ⁴ Have units. It will be understood by the formulator that some molecules may contain two R ⁴ units which are hydrogen, while some molecules are fully endblocked with anionic units. However, most preferably, more than about 95% of all R units present are endcapped with one or more anionic units as described herein.
Q is, C ₁ -C ₈ straight chain alkyl, C ₃ -C ₈ branched chain alkyl, benzyl, and quaternized units independently selected from the group consisting of mixtures, preferably methyl or benzyl And most preferably methyl,
X is a water-soluble anion in an amount sufficient to provide electronic neutrality. The counter ion, X, to a large extent, is derived from the unit used to perform the quaternization. For example, when methyl chloride is used as the quaternizing agent, chlorine (chloride ion) becomes counter ion X. When benzyl bromide is the quaternizing agent, bromine (bromide ion) is the main counter ion.

  Preferred zwitterionic hexamethylene diamines are of the formula (V)

式中、水溶性アニオンは、任意の好適な対イオンを含み得る。

Where the water soluble anion may comprise any suitable counter ion.

In a preferred embodiment, the antimicrobial cleaning composition is
a) 0.03% to 0.5%, based on the weight of the composition, of a nonionic antimicrobial agent which is 4-4'-dichloro-2-hydroxydiphenyl ether;
b) polyethylenimine ethoxylate having a side chain of formula (I) bound to the nitrogen atoms of the main chains PEI and PEI main chains which are 0.3% to 1.5% relative to the weight of the composition Some contain dirt dispersants,
-(EO) _b (PO) _c (I)
The polyethylenimine ethoxylate has a PEI backbone which is a Mw _n in the range of about 300 to about 3,000, b is in the range of 15 to 35, c is 0 or c is 10 to It is in the range of 25.

Auxiliary Components The antimicrobial cleaning compositions herein may include auxiliary components. Suitable auxiliary substances include anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, builders, chelating agents, rheology modifiers, dye transfer inhibitors, dispersants, enzymes and Enzyme Stabilizer, Catalyst Material, Bleach Activator, Hydrogen Peroxide, Hydrogen Peroxide Source, Preformed Peracid, Polymer Dispersant, Clay Soil Remover / Anti-redeposition Agent, Brightener, Foam Inhibitor, Dye, These include, but are not limited to, photobleaching agents, perfumes, perfume microcapsules, structural stretch agents, softeners, carriers, processing aids, hueing agents, structurants and / or pigments. In addition to the disclosure below, preferred examples and concentrations of such other adjuvants can be found in U.S. Patent Nos. 5,576,282, 6,306,812 (B1) and 6,326. , 348 (B1), which are incorporated by reference. The exact nature of these adjunct ingredients and their concentrations in the cleaning composition will depend on the physical form of the composition and the nature of the cleaning operation in which the composition is used.

  In one embodiment, the cleaning composition herein comprises an interface selected from the group consisting of anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants and combinations thereof. It further comprises an activator. Preferably, the composition is 3% to 50% anionic surfactant based on the weight of the composition and 0.1% to 10% nonionic surfactant based on the weight of the composition And.

In one embodiment, the composition comprises an anionic surfactant. Nonlimiting examples of anionic surfactants include linear alkyl benzene sulfonates (LAS) (preferably C ₁₀ -C ₁₆ LAS), C ₁₀ -C ₂₀ primary branched and random alkyl sulfates (AS) , C ₁₀ -C ₁₈ secondary (2, 3) alkyl sulfates, sulfated fatty alcohol ethoxylate (AES) (preferably C ₁₀ -C ₁₈ alkyl alkoxy sulfate (AE _x S), wherein in the formula, preferably x is 1 to 30, more preferably x is 1 to 3)), C ₁₀ -C ₁₈ alkyl alkoxy carboxylates (preferably containing 1 to 5 ethoxy units), US Pat. No. 6,020,303 and the like Medium chain branched alkyl sulfates as discussed in US Pat. No. 6,060,443, US Pat. No. 6,008,181 And medium-chain branched alkyl alkoxy sulfates as discussed in U.S. Pat. No. 6,020,303, discussed in WO 99/05243, WO 99/05242 and WO 99/05244. And modified alkyl benzene sulfonate (MLAS), methyl ester sulfonate (MES), as well as alpha-olefin sulfonate (AOS). Preferably, the composition is an anionic surfactant selected from the group consisting of LAS, AES, AS and combinations thereof, more preferably an anionic surfactant selected from the group consisting of LAS, AES and combinations thereof Containing agents. In a preferred embodiment, the composition comprises an anionic surfactant system comprising AES and LAS. The total concentration of anionic surfactant may be from 3% to 50% by weight of the liquid detergent composition, preferably 5% to 40% in the composition by weight of the composition More preferably 10% to 30%. For implementations where both AES and LAS are present in the composition, the weight ratio of AES to LAS is 0.1: 1 to 10: 1, preferably 0.5: 1 to 5: 1, more preferably 0. .7: 1 to 2: 1.

In one embodiment, the composition herein comprises a non-ionic surfactant, preferably an alkoxylated non-ionic surfactant. Non-limiting examples of alkoxylated nonionic surfactants suitable for use herein include C ₁₂ -C such as Neodol® nonionic surfactants available from Shell ₁₈ alkyl ethoxylates, C ₆ -C ₁₂ alkyl phenol alkoxylates (where the alkoxylate units are a mixture of ethyleneoxy and propyleneoxy units), ethylene oxide / propylene oxide such as Pluronic® available from BASF C ₁₂ -C ₁₈ alcohol condensates and C ₆ -C ₁₂ alkylphenol condensates with block alkylpolyamine ethoxylates, US Pat. Nos. 6,153,577, 6,020,303 and 6,093, As discussed in issue 856 ₁₄ -C ₂₂ chain branched alkyl alkoxylates, BAEx (wherein x is 1 to 30), U.S. Pat. No. 4,565,647 (Llenado) alkylpolysaccharides such as those discussed in, particularly, the United States Alkyl polyglycosides as discussed in patents 4,483,780 and 4,483,779, polyhydroxy fatty acid amides as discussed in US Patent 5,332,528, and US Ether-capped poly (oxyalkylated) alcohol surfactants such as those described in Patents 6,482,994 and WO 01/42408. Also useful as non-ionic surfactants herein are alkoxylated ester surfactants such as those having the formula R ¹ C (O) O (R ₂ O) n R ₃ (where , R ¹ is selected from linear and branched C ₆ -C ₂₂ alkyl or alkylene moieties, R ² is selected from C ₂ H ₄ and C ₃ H ₆ moieties, R ³ is H, CH ₃ , Selected from C ₂ H ₅ and C ₃ H ₇ moieties, n has a value between 1 and 20). Such alkoxylated ester surfactants include fatty acid methyl ester ethoxylates (MEE) and are known in the art. For example, U.S. Patent Nos. 6,071,873, 6,319,887, 6,384,009, and 5,753,606, WO 01/10391, and 96. See / 23049.

In one embodiment, the alkoxylated nonionic surfactants _herein, C 6 _{-C 22} alkoxylated alcohols, preferably _C 8 _{-C 18} alkoxylated alcohols, more preferably _C 12 _{-C 16} alkoxylated It is alcohol. Preferably, the C ₆ -C ₂₂ alkoxylated alcohol is an alkyl alkoxylated alcohol having an average degree of alkoxylation of 1 to 50, preferably 3 to 30, more preferably 5 to 20, even more preferably 5 to 9 . The alkoxylation in the present specification may be ethoxylation, propoxylation or a mixture thereof, but is preferably ethoxylation. In one embodiment, the alkoxylated nonionic surfactant is a C ₆ -C ₂₂ ethoxylated alcohol, preferably a C ₈ -C ₁₈ alcohol ethoxylated with an average of 5 to 20 moles of ethylene oxide, more preferably an average of 5 in to 9 moles of ethylene oxide are ethoxylated _C 12 _{-C 16} alcohol. The most preferred alkoxylated nonionic surfactant is a C ₁₂ -C ₁₅ alcohol ethoxylated with an average of 7 moles of ethylene oxide, such as Neodol® 25-7, which is commercially available from Shell.

  In a preferred embodiment, the antimicrobial cleaning composition herein is 3% to 50%, preferably 5% to 45%, more preferably 10% to 40% anionic, based on the weight of the composition. It further comprises a surfactant and 0.1% to 10%, preferably 0.3% to 7%, more preferably 0.5% to 5% of a nonionic surfactant.

  In one embodiment, the compositions herein comprise a cationic surfactant. Nonlimiting examples of cationic surfactants include quaternary ammonium surfactants which may have up to 26 carbon atoms and are alkoxylates as discussed in US Pat. No. 6,136,769. Quaternary ammonium (AQA) surfactants, including dimethylhydroxyethyl quaternary ammonium, dimethylhydroxyethyl lauryl ammonium chloride as discussed in US Pat. No. 6,004,922, WO 98/35002, Polyamine cationic surfactants as discussed in U.S. Pat. Nos. 98/35003, 98/35004, 98/35005 and 98/35006, U.S. Pat. No. 4,228,042 U.S. Pat. No. 4,239,660, U.S. Pat. Nos. 4,260,529 and 6,022,844. Cationic ester surfactants as discussed, and amino surfactants as discussed in US Pat. No. 6,221,825 and WO 00/47708, specifically amidopropyl dimethyl Amine (APA) is mentioned.

  In one embodiment, the composition herein comprises an amphoteric surfactant. Nonlimiting examples of amphoteric surfactants include derivatives of secondary and secondary amines, derivatives of heterocyclic secondary and tertiary amines, or quaternary ammonium, quaternary phosphonium or tertiary Derivatives of sulfonium compounds are mentioned. Preferred examples are alkyldimethyl betaines and cocodimethylamidopropyl betaines, C8 to C18 (or C12 to C18) amine oxides and sulfobetaines and hydroxybetaines, such as N-alkyl-N, N-dimethylamino-1-propanesulfonates. And betaines including (the alkyl group may be C8 to C18, or C10 to C14) and the like.

  Preferably, the amphoteric surfactant herein is selected from water soluble amine oxide surfactants. Useful amine oxide surfactants are

であり、式中、Ｒ^３は、Ｃ_８〜２２アルキル基、Ｃ_８〜２２ヒドロキシアルキル基又はＣ_８〜２２アルキルフェニル基であり、各Ｒ^４は、Ｃ_２〜３アルキレン基又はＣ_２〜３２ヒドロキシアルキレン基であり、ｘは、０〜約３であり、各Ｒ^５は、Ｃ_１〜３アルキル、Ｃ_１〜３ヒドロキシアルキル又は約１〜約３のＥＯを含むポリエチレンオキシドである。好ましくは、アミンオキシド界面活性剤は、Ｃ_{１０〜１８}アルキルジメチルアミンオキシド又はＣ_８〜１２アルコキシエチルジヒドロキシエチルアミンオキシドであってもよい。

In the formula, R ³ is a C _8-22 alkyl group, a C _8-22 hydroxyalkyl group or a C _8-22 alkylphenyl group, and each R ⁴ is a C _2-3 alkylene group or C _{2 32} hydroxyalkylene groups, x is 0 to about 3, and each R ⁵ is a polyethylene oxide containing C _1-3 alkyl, C _1-3 hydroxyalkyl or about 1 to about 3 EO. Preferably, the amine oxide surfactant may be a _C10-18 alkyl dimethyl amine oxide or a _C8-12 alkoxy ethyl dihydroxy ethyl amine oxide.

In one embodiment, the compositions herein comprise a rheology modifier (also referred to in certain circumstances as a "structurant"), the function of which is to suspend and stabilize the microcapsules, by packaging assembly It is to adjust the viscosity of the composition to be suitable. The rheology modifiers herein are those such as those disclosed in U.S. Patent Application Nos. 2006/0205631 A1, 2005/0203213 A1 and U.S. Patent Nos. 7294611 and 6855680. It may be any known ingredient capable of suspending particles and / or adjusting to a rheology suitable for liquid compositions. Preferably, the rheology modifiers are hydroxy-containing crystalline substances, polyacrylates, polysaccharides, polycarboxylates, alkali metal salts, alkaline earth metal salts, ammonium salts, alkanol ammonium salts, C ₁₂ -C ₂₀ aliphatic alcohols, di- A cationic polymer comprising a benzylidene polyol acetal derivative (DBPA), a diamide gelling agent, a first structural unit derived from methacrylamide and a second structural unit derived from diallyldimethyl ammonium chloride, and a combination thereof Be done. Preferably, the rheology modifier is a hydroxy-containing crystalline material generally having crystalline character, hydroxyl-containing fatty acids, fatty acid esters and fatty waxes such as castor oil and castor oil derivatives. More preferably, the rheology modifier is hydrogenated castor oil (HCO).

In a highly preferred embodiment, the antimicrobial cleaning composition of the present invention
a) 0.03% to 0.5% of the antibacterial agent which is 4-4'-dichloro-2-hydroxydiphenyl ether with respect to the weight of the composition,
b) 0.3% to 1% of the soil dispersant, based on the weight of the cleaning composition, of the formula (I) bound to the nitrogen atoms of the main chains PEI and PEI main chains:
-(EO) _b (PO) _c (I)
(Polyethyleneimine ethoxylate has a PEI backbone with a MW _n ranging from about 300 to about 3,000, b is ranging from 15 to 35, and c is A soil dispersant, which is 0 or c is in the range of 10 to 25 but is preferably 0)
c) 10% to 40% of an anionic surfactant system comprising AES and LAS, relative to the weight of the composition,
relative to the weight of d) a composition comprising a nonionic surfactant is 0.5% to 5% of an average 5 to 9 _C 12 _{-C 16} alcohols ethoxylated with moles of ethylene oxide.

Composition Preparation The cleaning compositions of the present invention are generally prepared by conventional methods known in the art for the preparation of cleaning compositions. Such methods typically include mixing the essential and optional components in any desired order to a relatively uniform state, with or without heating, cooling, application of vacuum, etc., and thereby Providing a cleaning composition containing the components in the required concentration.

Water-soluble pouches In one embodiment, the antimicrobial cleaning compositions herein are contained within a water-soluble film, thereby forming a water-soluble pouch. The pouch may be used by the user to change the amount used according to the required operation, eg a single dose of the composition herein suitable for a single wash, or for example the amount of laundry or the degree of soiling. It may be of convenient size to accommodate any of the partial amounts that can be made more flexible.

  The water-soluble film of the pouch is preferably made of a polymer. The film can be obtained by methods known in the art, for example, casting, blow molding, extrusion, injection molding of polymers. Nonlimiting examples of polymers for producing water-soluble films such as polyvinyl alcohol (PVA), polyvinyl pyrrolidone, polyalkylene oxide, (modified) cellulose, (modified) cellulose-ether or-ester or-amide, polyacrylate, etc. Copolymers of polycarboxylic acids and salts maleic acid / acrylic acid, polyamino acids or peptides, polyamides such as polyacrylamides, polysaccharides such as starch and gelatin, natural gums such as xanthan and carragum. Preferably, the water soluble film is a polyacrylate and a water soluble acrylate copolymer, methylcellulose, carboxymethylcellulose sodium, dextrin, ethylcellulose, hydroxyethylcellulose, hydroxypropyl methylcellulose, maltodextrin, polymethacrylate, polyvinyl alcohol, hydroxypropyl methylcellulose (HPMC), and It includes a polymer selected from the group consisting of these combinations. Most preferably, the water soluble film comprises polyvinyl alcohol, such as M8639 available from MonoSol. Suitable polymers for producing water-soluble films of pouches are described in US Pat. No. 6,995,126.

  The pouch herein may comprise a single compartment or a plurality of compartments, preferably comprising a plurality of compartments, for example two compartments or three compartments. When multiple compartments are applied, one or more of the multiple compartments contain the above-described antimicrobial cleaning composition. Preferably, the pouch comprises a plurality of films forming a plurality of compartments, ie the internal volume of the plurality of films is divided into a plurality of compartments. Examples of these multi-compartment pouches are described in U.S. Patent Nos. 4,973,416, 5,224,601, and 8,066,818.

  The pouch of the present invention can be made by any suitable process known in the art. Examples of the preparation process of the pouch are described in U.S. Patent Nos. 6,995,126, 7,127,874, 8,156,713, 7,386,971, and 7,439, No. 215, and U.S. Patent Application Publication No. 2009/199877.

Method of Use Another aspect of the invention relates to the use of the cleaning composition for treating areas, in particular fabrics, with an antimicrobial effect. The method comprises the steps of charging 5 g to 120 g of the above cleaning composition into a water containing scrubber to form a cleaning solution. The washing liquid in the washing and washing machine in the present specification preferably has a volume of 1 L to 50 L, or 1 L to 20 L by hand washing, and 20 L to 50 L of washing by a washing machine. Preferably, the antibacterial effect in the present specification is evaluated by the JISL 1902 method. The temperature of the cleaning solution is preferably in the range of 5 ° C to 60 ° C.

  The dosages in the methods herein may vary depending on the type of cleaning. In one embodiment, the method comprises the step of charging 5 g to 60 g of the cleaning composition into a hand-washer (e.g. 4 L). In an alternative embodiment, the method comprises the step of charging 60 g to 120 g of the cleaning composition into a washing machine (e.g. 30 L).

  Preferably, the method herein further comprises the step of contacting the fabric with a cleaning solution, the fabric requiring an antimicrobial treatment. For example, the presence of gram positive bacteria and / or gram negative bacteria is suspected on the fabric. The step of contacting the fabric with the cleaning solution is preferably after the step of charging the cleaning composition to the cleaner. The method comprises the steps of contacting the fabric with the cleaning composition prior to the step of loading the cleaning composition into the washer, ie, cleaning the fabric with the composition for a certain period of time (preferably 1 minute to 10 minutes). The method may further include a pretreatment step.

Test Method The antibacterial effect of the laundry detergent composition is evaluated according to the method defined in JIS L 1902 described below.

1. Preparation of microorganisms:
A. An aliquot of normal broth medium is aseptically added to the lyophilized S. aureus or K. pneumoniae culture. The culture is dissolved and suspended in a normal broth medium to obtain a suspension. The suspension of one platinum ear is streaked out on nutrient agar plates and incubated at 37 ° C. for 24 hours to obtain a first generation passage of bacterial suspension. Transfer the first generation of subculture of 1 platinum loop of bacterial suspension to 20 mL of ordinary broth medium with shaking, and incubate at 37 ° C. for 24 hours to obtain a second generation of bacterial suspension. A culture broth is obtained. Transfer the second generation subculture of 0.4 mL of the bacterial suspension to another 20 mL of normal broth medium with shaking, and incubate at 37 ° C. for 3 hours to produce the third generation of bacterial suspension Obtain a subculture fluid of
B. Working broth is obtained by diluting the third generation subculture of the bacterial suspension to 1 × 10 5 cells / mL using common broth medium diluted 1/20.
C. Store working medium at 4 ° C. Working cultures can not be stored overnight.

2. Fabric cleaning:
A. Two pieces of fabric, each 5 cm wide x 2.5 m long (32 yarns / cm x 32 yarns / cm, 100% plain weave cotton) are boiled in 3 L of solution for 1 hour. The solution is prepared with 1.5 g of nonionic immersion agent, 1.5 g of sodium carbonate and 3000 ml of distilled water. A non-ionic dip is prepared with 5.0 g of alkylphenol ethoxylate, 5 g of sodium carbonate and 1000 mL of distilled water. The piece of fabric is rinsed with boiling deionized water for 5 minutes. The piece of fabric is placed in cold deionized water for 5 minutes and allowed to dry in the room. One piece of fabric was taken as the test fabric piece of steps 2B-2I below, and the other piece of fabric was used as a control (no implementation of steps 2B-2I).
B. One end of the test fabric piece obtained from step 2A is fixed on the stainless steel spindle at an outer position along the horizontal extension of the stainless steel spindle. The stainless steel spindle has three horizontal stands connected to one another. A piece of test cloth is wound on three horizontal stands of a stainless steel spindle with sufficient tension to obtain a cloth-wound spindle having a 12-turn wound cloth. The other end of the test fabric piece is pinned to the outside of the 12-fold wound fabric. The fabric-wound spindle is sterilized at 121 ° C. for 15 minutes at steam pressure.
C. 5. 903 g of calcium chloride dihydrate and 2.721 g of magnesium chloride hexahydrate are dissolved in 100 mL of distilled water and then the mixture is sterilized at 121 ° C. for 20 minutes at steam pressure. Add 1 mL of the mixture to 1 L of distilled water to obtain a hard aqueous solution.
D. A sufficient amount of sample is added to 1 L of the hard aqueous solution obtained from step 2C to obtain a solution having a concentration of 2069 ppm. The solution is mixed with a magnetic stirrer for 4 minutes. 250 mL of mixed solution is supplied to the exposure chamber to obtain a wash. The exposure chamber is placed in a water bath to achieve a test temperature of (25 ± 1) ° C. The exposure chamber is then sterilized at 121 ° C. for 15 minutes at steam pressure.
E. The fabric wound spindle obtained from step 2B is aseptically immersed in the wash solution in the exposure chamber and the exposure chamber is closed with a lid.
F. The exposure chamber is fixed on the tumbler. Rotate the tumbler for 10 minutes. The fabric wound spindle is then removed from the exposure chamber. Place the fabric wound spindle into the Haier iwash-1p top-loading washer and rinse for 2 minutes.
G. Discard the wash solution from the exposure chamber and then add 250 mL of sterile distilled water to the exposure chamber. The rinsed fabric wrapped spindle is immersed in freshly added distilled water in the exposure chamber. Rotate the tumbler for 3 minutes.
H. Repeat step 2G.
I. The fabric wrapped spindle is aseptically removed from the exposure chamber and the test fabric strip is removed from the spindle. The test fabric pieces are allowed to air dry overnight.

3. Cloth culture:
A. Cut the cleaned test cloth pieces obtained from step 2I into square pieces with a side length of 2 cm. Three sets of 0.4 g sections are taken as samples for the following steps.
B. Each set of samples is placed in a vial and the samples are then sterilized by vapor pressure at 121 ° C. for 15 minutes. After sterilization, the samples are allowed to dry for 1 hour without lid in a clean bench.
C. Inoculate each dried sample with 0.2 mL of working culture fluid obtained from step 1C. The vial containing the inoculated sample is incubated at 37 ° C. for 18 hours.
D. The viable bacteria on the inoculated sample are harvested, seeded on nutrient agar plates and cultured for 24 to 48 hours at 37 ° C. Count all colony forming units (CFU) of each set of samples to obtain 3 sets of averaged results. Take the common logarithm of the CFU value as Mb.
E. In steps 3A-3D, the piece of fabric obtained from step 2A is used as a control (steps 2B-2I are not performed). Take the common logarithm of the CFU value as Ma.

4. Calculation of bacteriostatic activity value:
Bacteriostatic activity value = Mb-Ma
A bacteriostatic activity value of greater than 2.2 indicates an acceptable level of antibacterial effect, a value of greater than 2.5 indicates a good antibacterial effect, and a value of greater than 3.0 indicates an excellent antibacterial effect. Thus, bacteriostatic activity values below 2.2 show less than acceptable antimicrobial efficacy.

  The examples set forth herein are meant to illustrate the present invention, but are not used to limit or otherwise define the scope of the present invention. Examples 1A-1C and 2A-2B are examples according to the present invention, and examples 2C-2D are comparative examples.

Examples 1A-1C: Formulation of Liquid Laundry Detergent Compositions The following liquid laundry detergent compositions shown in Table 1 are made containing the listed components in the listed ratios (% by weight).

ａ Ｎｅｏｄｏｌ（登録商標）２５−７は、非イオン性界面活性剤としての、Ｓｈｅｌｌから入手可能な平均７モルのエチレンオキシドでエトキシ化されたＣ_１２〜Ｃ_１５アルコール
ｂ キレート剤としての、ジエチレントリアミン五酢酸五ナトリウム塩
ｃ ＭＷ_ｎ約６００のＰＥＩ主鎖及び（ＥＯ）_２０の側鎖を有するポリエチレンイミエトキシレート
ｄ ＭＷ_ｎ約６００のＰＥＩ主鎖及び（ＥＯ）_２０（ＰＯ）_５の側鎖を有するポリエチレンイミエトキシレート
ｅ 式（Ｖ）の双性イオン性ヘキサメチレンジアミン
ｆ Ｔｉｎｏｓａｎ（登録商標）ＨＰ１００は、ＢＡＳＦから入手可能な４−４’−ジクロロ−２−ヒドロキシジフェニルエーテル

a Neodol® 25-7 is a non-ionic surfactant, diethylenetriaminepentaacetic acid as an average of 7 moles of ethylene oxide ethoxylated C ₁₂ -C ₁₅ alcohol b chelating agent available from Shell polyethylene having a polyethyleneimine ethoxylate d MW _n from about 600 PEI backbone and _(EO) 20 _{(PO) 5} side chain of having a side chain of pentasodium salt c MW _n of about 600 PEI backbone and _{(EO) 20} Imiethoxylate e Zwitterionic hexamethylenediamine of the formula (V) f Tinosan® HP 100 is a 4-4′-dichloro-2-hydroxydiphenyl ether available from BASF

Examples 2A-2D: Formulation of Liquid Laundry Detergent Compositions The following liquid laundry detergent compositions shown in Table 2 are made containing the listed components in the listed ratios (% by weight).

ａ Ｎｅｏｄｏｌ（登録商標）２５−７は、非イオン性界面活性剤としての、Ｓｈｅｌｌから入手可能な平均７モルのエチレンオキシドでエトキシ化されたＣ１２〜Ｃ１１５アルコール
ｂ ＭＷ_ｎ約６００のＰＥＩ主鎖及び（ＥＯ）_２０の側鎖を有するポリエチレンイミエトキシレート
ｃ Ｔｉｎｏｓａｎ（登録商標）ＨＰ１００は、ＢＡＳＦから入手可能な４−４’−ジクロロ−２−ヒドロキシジフェニルエーテル

a Neodol® 25-7 is a non-ionic surfactant, C12-C115 alcohol ethoxylated with an average of 7 moles of ethylene oxide available from Shell b MW _n PEI backbone of about 600 _n EO) Polyethylene imidoethoxylate having ₂₀ side chains c Tinosan® HP 100 is a 4-4′-dichloro-2-hydroxydiphenyl ether available from BASF

Preparation of Liquid Laundry Detergent Compositions of Examples 1A-1C and 2A-2D The liquid laundry detergent compositions of Examples 1A-1C and 2A-2D are
a) mixing the combination of NaOH (if present) and water in a batch container by applying a shear force of 200 rpm;
b) the citric acid (some), and if there borate () and _C 11 was added to _~ 13 LAS batch vessel and continue to mix by adding shearing force 200rpm step,
c) cooling the temperature of the mixture obtained in step b) to 25 ° C .;
d) C _12-14 AE _1-3 S, Na-DTPA (if present), Neodol® 25-7, C ₁₂ -C ₁₈ fatty acid, 1,2 propanediol (if present), monoethanolamine Calcium chloride (if present), sodium cumene sulfonate (if present), silicone emulsion (if present), sodium polyacrylate (if present), polyethyleneimine ethoxylate (if present), zwitterionic hexameric Adding the methylene diamine (if any) and Tinosan® HP 100 into the batch container and mixing by applying a shear force of 250 rpm until the mixture is homogeneously mixed, adjusting the pH to 8;
e) Add brightener (if present), protease (if present), amylase (if present), dye (if present) and perfume oil (if present) into the batch container and mix by applying shear force of 250 rpm And thereby forming a liquid laundry detergent composition,
The components in the composition are present in the amounts shown for Examples 1A-1C and 2A-2D in Tables 1 and 2.

Comparative Data on Antibacterial Effects of Examples 2A-2D A comparative experiment to measure the antibacterial effects of the compositions of Examples 2A-2B and Comparative Examples 2C-2D is carried out according to the JIS L 1902 method described above. Specifically, the composition is added as a sample in step 2D of the method. Table 3 shows bacteriostatic activity values against Staphylococcus aureus (gram-positive bacteria), and Table 4 shows bacteriostatic activity values against Klebsiella pneumoniae (gram-negative bacteria).

  As shown in Tables 3 and 4, the laundry detergent compositions according to the present invention (Examples 2A and 2B) were compared to both the gram positive bacteria and the gram negative bacteria with the comparative compositions (Comparative Examples 2C and 2D). In comparison, it shows the improvement of the antibacterial action. In particular, the laundry detergent composition according to the present invention provides an excellent antibacterial effect against Staphylococcus aureus, which is frequently found on human skin.

  All percentages, ratios and proportions are calculated based on the weight of the total composition, unless otherwise indicated. All temperatures are degrees Celsius (° C.) unless otherwise stated. All measurements are performed at 25 ° C unless otherwise specified. All concentrations of components or compositions relate to the level of activity of the components or composition, excluding impurities such as residual solvents or byproducts that may be present in commercial sources.

  It is understood that all maximum numerical limitations given throughout the specification are to be construed as including all lower numerical limitations as if such lower numerical limitations were expressly written herein. Should. All minimum numerical limitations given throughout this specification are inclusive of all higher numerical limitations, as if higher numerical limitations were explicitly stated herein. Are all numerical ranges given throughout the present specification all narrow numerical ranges falling within such wider numerical ranges and are all such narrow numerical ranges explicitly described herein? As in

  The dimensions and values disclosed herein are not to be understood as being strictly limited to the precise numerical values set forth. Rather, unless otherwise specified, each such dimension is intended to mean both the recited value and a functionally equivalent range surrounding that value. For example, the dimension disclosed as "40 mm" means "about 40 mm".

  All documents cited herein, including all patents or patent applications that are cross-referenced or related, are hereby incorporated by reference in their entirety, unless expressly excluded or otherwise limited. Incorporated into the book. The citation of any document is not an admission that such document is prior art to any invention disclosed or claimed herein, and such document, alone or in any other reference, is not. Neither is it to be taught, suggested, or disclosed any of such inventions in any combination with. Furthermore, if any meaning or definition of a term in this document conflicts with any meaning or definition of the same term in the document incorporated by reference, then the meaning or definition given to that term in this document shall prevail. I assume.

  While particular embodiments of the present invention have been illustrated and described, it would be obvious to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the present invention. Accordingly, all such changes and modifications that are included within the scope of the present invention are intended to be covered by the appended claims.

Claims (14)

a) about 0.001% to about 3% of a non-ionic antimicrobial agent, based on the weight of the cleaning composition,
b) a soil dispersant comprising about 0.1% to about 3% by weight of the composition of an alkyleneamine main chain and a side chain bonded to a nitrogen atom of the alkyleneamine main chain, said side The chain is of formula (I):
-(EO) _b (PO) _c (I)
An antimicrobial cleaning composition comprising: wherein b is in the range of 3 to 60 and c is in the range of 0 to 60.   The composition according to claim 1, wherein the non-ionic antimicrobial agent is diphenyl ether. The non-ionic antimicrobial agent is of the formula (II):

(In the formula,
Each Y is independently selected from chlorine, bromine or fluorine
Each Z is independently selected from SO ₂ H, NO ₂ or C ₁ -C ₄ alkyl,
r is 0, 1, 2 or 3;
o is 0, 1, 2 or 3;
p is 0, 1 or 2;
m is 1 or 2;
n is 0 or 1)
The composition according to claim 2, which is a hydroxydiphenyl ether compound of   The non-ionic antimicrobial agent is selected from the group consisting of 4-4'-dichloro-2-hydroxydiphenyl ether, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, and combinations thereof. Composition as described.   The composition according to claim 4, wherein the non-ionic antibacterial agent is 4-4'-dichloro-2-hydroxydiphenyl ether. The hydrophobic soil dispersant is
Formula (I) bound to a nitrogen atom of the main chain polyethyleneimine (PEI) and PEI main chain:
-(EO) _b (PO) _c (I)
(Wherein b is in the range of 3 to 60, c is in the range of 0 to 60) polyethyleneimine ethoxylate having a side chain,
Formula (III):

(Wherein R is a group of formula (IV):
-(EO) _n R ⁴ (IV)
Ethyleneoxy units, where n is in the range of 10 to 40, R ⁴ is hydrogen, an anionic unit or a combination thereof, Q is C ₁ -C ₈ straight chain alkyl, C _{3 to} C ₈ branched alkyl, benzyl and quaternized units independently selected from the group consisting of a mixture thereof, wherein X is a water-soluble anion), and a group consisting of a combination thereof The composition according to claim 1, comprising a compound selected from The polyethyleneimine ethoxylate has a PEI backbone is the number average molecular weight ranging from about 300 to about 3,000 (Mw _n), b is in the range of 15 to 35, c is 0, wherein 7. The composition according to item 6. The polyethyleneimine ethoxylate has a PEI backbone with a MW _n ranging from about 300 to about 3,000, b is in the range of 15 to 35, and c is in the range of 10 to 25. The composition as described in 6. Compounds of formula (III) have the formula (V):

The composition according to claim 6, wherein the composition comprises   The non-ionic antimicrobial agent is present from about 0.01% to about 1%, more preferably from about 0.03% to about 0.5%, based on the weight of the cleaning composition, and the soil dispersant is present. The composition according to claim 1, wherein about 0.2% to about 2%, more preferably about 0.3% to about 1.5%, based on the weight of the cleaning composition is present.   About 3% to about 50% anionic surfactant based on the weight of the composition, and about 0.1% to about 10% nonionic surfactant based on the weight of the composition The composition of claim 1 further comprising.   2. A method according to claim 1, wherein after a contact time of 10 minutes in an aqueous solution of 2069 ppm according to the JIS L 1902 method, a log reduction of at least 2.2 is obtained with respect to Staphylococcus aureus and / or Klebsiella pneumoniae. Composition as described. a) about 0.03% to about 0.5% of the non-ionic antimicrobial agent that is 4-4'-dichloro-2-hydroxydiphenyl ether, based on the weight of the cleaning composition;
b) from about 0.3% to about 1.5%, by weight of the cleaning composition, of the soil dispersant PEI as main chain and a nitrogen atom of the PEI main chain (I):
-(EO) _b (PO) _c (I)
(Polyethyleneimine ethoxylate having a PEI backbone with a Mwn in the range of about 300 to about 3,000, b is in the range of 15 to 35, and c is a polyethyleneimine ethoxylate having a side chain of Dirt dispersant, which is 0)
c) An anionic surfactant system comprising about 10% to about 40% of alkyl ethoxy sulfate (AES) and linear alkyl benzene sulfonate (LAS) based on the weight of the composition,
relative to the weight of d) the composition, of from about 0.5% to about 5%, and _C 12 _{-C 16} alcohols ethoxylated with an average 5-9 moles of ethylene oxide, and a nonionic surfactant A composition according to claim 1, comprising   The composition according to claim 1, contained in a water-soluble film, preferably a water-soluble film comprising polyvinyl alcohol.