JP2023533273A - Oral composition for improving bad breath - Google Patents

Abstract

The present invention is an oral cavity composition for improving bad breath, and is used to remove volatile sulfides such as hydrogen sulfide, methyl mercaptan, and dimethyl mercaptan that cause bad breath. The present invention relates to an oral composition capable of effectively removing decomposed components. Specifically, the present invention is an oral composition for improving halitosis containing chitosan and a green tea extract as active ingredients, and the oral composition for improving halitosis comprises a polyol, a polymer, a bactericide, a caries inhibitor, and an effective oral malodor remover. It can further comprise one or more additional ingredients selected from the group consisting of ingredients, pH adjusting agents, preservatives, preservatives, flavoring agents, sweetening agents, fragrances, dyes and solvents. The oral composition for improving halitosis of the present invention improves halitosis by effectively removing halitosis, has excellent palatability, and feels very good when used.

Description

TECHNICAL FIELD The present invention relates to an oral composition, specifically an oral composition for improving halitosis that can remove halitosis components to improve halitosis.

In modern society, along with industrialization and westernization, the causes and symptoms of oral-related diseases are diversifying due to changes in lifestyle and dietary habits, and oral-related diseases and related problems have been reported as serious social problems. there is

The oral cavity is a very important organ for respiration and food intake, but it is also an organ that is constantly exposed to the external environment through air and food. Therefore, if you do not keep your oral cavity clean by brushing your teeth, plaque and tartar will form around your teeth and gums, which can lead to various diseases.

The World Health Organization (WHO) recognizes oral diseases such as dental caries, periodontal disease, bad breath and oral pain as one of the major health problems to be solved in the future. Globally, 60-90% of adolescents and 60% of adults have caries and periodontal disease, and 15-20% of middle-aged adults aged 35-44 years have severe periodontal disease. have a disease. Such oral diseases are not only the leading cause of tooth loss, but also a potential risk factor for diseases such as cardiovascular disease, bacterial pneumonia, low birth weight, diabetes complications and osteoporosis. It is reported that

As mentioned above, the human oral cavity, which is an organ that is constantly exposed to the external environment through air and food, is highly humid and maintains a stable body temperature, making it an ideal environment for food to spoil and for bacteria to proliferate. be. More than 700 species of various bacteria are resident in the human oral cavity, and the bacteria in the oral cavity are composed of resident bacteria and pathogenic bacteria. Indigenous bacteria prevent the growth of pathogenic bacteria and maintain oral health, whereas most of the bacteria that cause oral diseases are present in dental plaque, which is a bacterial film formed between teeth and gums. known to do. Pathogenic bacteria produce toxins and acids from dental plaque (plaque), the toxins produced by pathogenic bacteria enter the periodontal tissue and cause inflammation of the gums, destruction and infection of the alveolar bone, and the acid produced by the pathogenic bacteria causes tooth decay. It dissolves the surface of the tooth and causes dental caries, and may also act as a cause of bad breath.

In relation to halitosis induction, with the increase in the range of interpersonal relationships and activities accompanying social development and the development of hygiene concepts, awareness of halitosis is gradually increasing, and consumers actively try to care for halitosis. tend to increase more and more. In response to these changes, various studies have been conducted both in Japan and overseas, such as performing effective treatments to remove bad breath and adding drugs to toothpaste, mouthwash, capsules, adhesives, etc.

Causes of halitosis can be broadly classified into two: intraoral causes and extraoral causes. Diseases can be mentioned, and extraoral causes include respiratory diseases, gastrointestinal diseases, etc., and various causes such as hunger, menstruation, smoking and drinking.

Halitosis caused by oral causation, which is the main cause among the above-mentioned causes, is caused by enzymes in the oral cavity that use food debris present in saliva, microorganisms, oral epithelium, desorbed oral mucosa and connective tissue as protein sources, and decompose these. It is known that volatile sulfides are generated by Volatile sulfides, which are the main components causing bad breath, include hydrogen sulfide, methyl mercaptan and dimethyl mercaptan. and so on.

Looking at conventional technologies related to halitosis removal, research has mainly been conducted on toothpastes and mouthwashes containing antibacterial agents against halitosis-causing bacteria and masking ingredients against halitosis-causing substances. However, these preparations have some restrictions in use in order to develop and maintain the breath-removing effect. For example, toothpaste has the disadvantage that it cannot maintain the effective ingredients after brushing the teeth. Attempts have been made to increase the drug delivery effect by applying polymers to compensate for these shortcomings. The disadvantage of limited space still remains because one must brush one's teeth and rinse one's mouth with water. In addition, research was conducted on formulations such as mouth sprays and breath films. However, in the case of mouth sprays and breath films, there is a problem that the duration of effect is short and the experience of efficacy is limited. Phenomena such as agglomeration occur, and problems in distribution are further added.

In addition, in order to suppress bad breath that occurs in the oral cavity, substances that cause mouth teeth, such as volatile sulfides such as hydrogen sulfide, methyl mercaptan, and dimethyl mercaptan, which are decomposition components of protein wastes, are removed. Research is underway to This has been evaluated as being more effective than the control of microbes involved in halitosis, which has limited efficacy. Research needs are increasing.

An object of the present invention is to provide an oral composition capable of improving bad breath through effective removal of bad breath, unlike conventional toothpastes.

As described above, in order to remove volatile sulfides such as hydrogen sulfide, methyl mercaptan and dimethyl mercaptan that cause bad breath, the present invention is effective in decomposing protein waste products that generate volatile sulfides. To provide an oral composition for improving halitosis, which is an oral composition that can be effectively removed.

Specifically, the oral cavity composition for improving halitosis of the present invention may be an oral composition for improving halitosis containing chitosan and a green tea extract as active ingredients.

The chitosan may have a weight average molecular weight (Mw) of 10,000 Da to 57,000 Da.

In this respect, the oral composition for improving bad breath is an oral composition for improving bad breath containing chitosan and a green tea extract as active ingredients, and the chitosan has a weight average molecular weight (Mw) of 10,000 Da to 57,000 Da. It may be characterized by being

The chitosan content may preferably be 0.01 to 0.05% (w/w) based on the weight of the oral cavity composition for improving halitosis. From this aspect, the oral cavity composition for improving halitosis has a chitosan content of 0.01 to 0.05 parts by weight based on 100 parts by weight of the oral composition for improving halitosis. good.

Due to the content of catechins contained in the green tea extract, the green tea extract may impart an astringent taste to the oral composition as a whole and reduce the palatability of the oral composition as a whole. The content is affected by the content of catechins contained in the green tea extract.

From this aspect, the content of the green tea extract can be adjusted based on the content of catechins contained in the green tea extract. The content of the extract is adjusted so that the content of catechins contained in the green tea extract is 0.1 to 0.2% (w/w) based on the weight of the oral composition for improving bad breath. can do.

Therefore, the content of the green tea extract is preferably based on the content of catechins contained in the green tea extract, and based on 100 parts by weight of the oral cavity composition for improving bad breath, the content of the catechins is The content may be 0.1 to 0.2 parts by weight.

In addition, the oral cavity composition for improving halitosis contains polyol, polymer, bactericide, solubilizer, antibacterial component, halitosis removing active component, gum disease preventive component, pH adjuster, preservative, antiseptic, flavoring agent, and sweetener. It may further comprise one or more additional ingredients selected from the group consisting of agents, fragrances, dyes and solvents.

The oral cavity composition for improving halitosis of the present invention uses chitosan and green tea extract, which are natural products, as the main ingredients, so it is safe because the use of synthetic compounds harmful to the human body can be minimized. In addition, it has an excellent effect of removing bad breath, but also has an excellent degree of palatability without causing discomfort such as astringency in use, and has the effect of improving the feeling of use and satisfaction of consumers.

1 shows the results of measuring halitosis of a subject before and after using the present invention using a halitosis measuring instrument according to an example of the present invention. 4 is a photograph showing the result of measuring the effect of removing halitosis-inducing substances for reducing halitosis of the oral cavity composition of the present invention, according to an example of the present invention.

The present invention is an oral composition for improving bad breath containing chitosan and green tea extract as active ingredients,
The chitosan has a weight average molecular weight (Mw) of 10,000 Da to 57,000 Da,
The green tea extract contains catechins,
The content of the chitosan is 0.01 to 0.05 parts by weight based on 100 parts by weight of the oral composition for improving bad breath,
The content of the green tea extract is based on the content of catechins contained in the green tea extract, and based on 100 parts by weight of the oral cavity composition for improving bad breath, the content of the catechins is 0.5 parts by weight. 1 to 0.2
It relates to an oral cavity composition for improving bad breath characterized by

Preferred embodiments of the present invention are described below in order to explain the present invention in detail. The following examples are for the purpose of illustrating the present invention, and the scope of the present invention is not limited in any way by the following examples. included within the scope of

TECHNICAL FIELD The present invention relates to an oral composition for improving halitosis containing chitosan and green tea extract as active ingredients.

The oral composition for improving bad breath is an oral composition for improving bad breath containing chitosan and a green tea extract as active ingredients, and the chitosan has a weight average molecular weight (Mw) of 10,000 Da to 57,000 Da. There may be.

The oral cavity composition for improving halitosis may contain 0.01 to 0.05 parts by weight of chitosan based on 100 parts by weight of the oral composition for improving halitosis.

The chitosan content may preferably be 0.01 to 0.05% (w/w) based on the weight of the oral cavity composition for improving halitosis.

The green tea extract may contain catechins, and the content of the green tea extract is based on the content of catechins contained in the green tea extract. The catechin content may be 0.1 to 0.2 parts by weight based on parts by weight.

The green tea extract may contain catechins, and the content of catechins contained in the green tea extract is preferably from 0.1 to 0.1, based on the weight of the oral composition for improving bad breath. It may be 0.2% (w/w).

The oral cavity composition for improving bad breath comprises a polyol, a polymer, a bactericide, a caries inhibitor, an active ingredient for removing bad breath, a pH adjuster, a preservative, an antiseptic, a flavoring agent, a sweetening agent, a fragrance, a pigment, and a solvent. It may further comprise one or more additional ingredients selected from the group.

Unless otherwise specified herein, the average molecular weight is the molecular weight of a polymer compound that is a mixture of multiple molecular species with different molecular weights, i.e. the average value of the molecular weights of multiple molecular species with different molecular weights. means The average molecular weight explicitly indicates the method of averaging, such as number average molecular weight and weight average molecular weight.

Unless otherwise specified herein, a composition includes products containing the specified ingredients in the specified amounts, as well as products containing the specified ingredients in the specified amounts, either directly or indirectly from a blend of the specified ingredients in the specified amounts. It is meant to include the resulting products.

Unless otherwise specified herein, effective amount means an amount of the extract or composition of the present invention effective to bring about the desired therapeutic, alleviating, suppressing or prophylactic effect.

Unless otherwise specified herein, solubilizing agent means a surfactant used to solubilize substances that are insoluble in water. The surfactant may be an anionic surfactant, an amphoteric surfactant or a nonionic surfactant, examples of which include amide-based nonionic surfactants, sodium lauryl sulfate, polyoxyethylene-polyoxypropylene (poloxamer), polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, anionic surfactants such as taurate-based or betaine-based amphoteric surfactants.

The inventors of the present invention have found that existing oral compositions for improving bad breath mainly remove volatile sulfides such as hydrogen sulfide, methyl mercaptan and dimethyl mercaptan, which are causative substances of bad breath, in order to remove bad breath. In spite of the fact that the control of microorganisms that generate decomposition components of protein wastes is concentrated on the control of microorganisms that generate components that decompose protein wastes, and for that purpose, antibacterial substances derived from natural products and antibacterial substances derived from compounds are added to existing oral compositions for improving halitosis, bad breath can be removed. Focusing on the limited efficacy, research was conducted on oral compositions capable of effectively removing protein wastes, focusing on the protein wastes themselves rather than the control of microorganisms.

As a result of conducting these studies based on natural products whose safety has been verified, rather than artificial compounds with safety issues, it was found that when chitosan and green tea extract are used in combination, even a simple gargling can eliminate protein waste. It was only confirmed that the removal was easy, the effect of removing protein wastes was affected by the molecular weight of chitosan, and the amount of green tea extract added also affected the effect of removing wastes. However, it was confirmed that the amount of chitosan added and the green tea extract, specifically the content of catechins contained in the green tea extract, affect the palatability of the oral composition as a whole. has a weight average molecular weight (Mw) of 11,170 Da, a chitosan content of 0.05% (w/w), and a green tea extract content of catechins contained in the green tea extract We have found that 0.1 to 0.2% (w/w), based on the amount, is most suitable. The oral cavity composition for improving bad breath produced based on the above results uses chitosan and green tea extract, which are natural products, as main ingredients, so that the use of synthetic compounds harmful to the human body is minimized. Not only is it safe because it can remove bad breath, but it is also highly palatable without causing inconvenience such as astringency when used, improving the feeling of use and satisfaction of consumers. The present invention was completed based on the fact that the problems of the existing oral compositions for improving bad breath can be solved.

The present invention will be described in more detail below.

In order to solve the problems of existing paste-type toothpastes that use synthetic surfactants, the present invention maintains a certain level of viscosity without using synthetic surfactants and provides a smooth feeling of use. The present invention relates to a paste-type oral composition for improving halitosis that can ensure an excellent feeling of use.

The oral cavity composition for improving halitosis of the present invention relates to an oral composition for improving halitosis containing chitosan and a green tea extract as active ingredients.

The chitosan has a weight-average molecular weight (Mw) of 10,000 Da to 57 in terms of the effect of removing protein wastes and the effect of suppressing the production of volatile sulfides such as hydrogen sulfide, methyl mercaptan and dimethyl mercaptan that cause bad breath. ,000 Da, preferably 10,000 Da to 13,000 Da, more preferably 11,150 to 11,200 Da, even more preferably 11,170 Da.

In this respect, the oral composition for improving bad breath is an oral composition for improving bad breath containing chitosan and a green tea extract as active ingredients, and the chitosan has a weight average molecular weight (Mw) of 10,000 Da to 57,000 Da. It may be characterized by being

The chitosan is a natural polymer obtained by deacetylating chitin present in the shells of crustaceans such as crabs and shrimps with high temperature and strong alkali. The chitosan is a substance having various physiological functions such as antibacterial activity, antifungal activity, and immune activity enhancing effect.

The chitosan inhibits the growth of oral bacteria to prevent gum disease, and at the same time, it can keep the oral cavity clean due to its adsorption and cohesive action. Since the chitosan has an acetylamino group with a very strong hydrogen bond in its molecule, it has a characteristic of not being dissolved in water. It has water solubility when it is made into a low molecular weight compound. The chitosan is preferably a high-molecular-weight chitosan that is highly effective while being water-soluble chitosan, such as ordinary chitosan obtained by deacetylating chitin (water-insoluble chitosan). It may be carboxyethyl chitosan (N-Carboxyethyl Chitosan) in which a carboxyethyl group is bound to .

The chitosan content is preferably 0.01 to 0.05% (w /w).

From this aspect, the oral cavity composition for improving halitosis has a chitosan content of 0.01 to 0.05 parts by weight based on 100 parts by weight of the oral composition for improving halitosis. good.

Due to the content of catechins contained in the green tea extract, the green tea extract may impart an astringent taste to the oral composition as a whole and reduce the palatability of the oral composition as a whole. The content is affected by the content of catechins contained in the green tea extract.

From this aspect, the content of the green tea extract can be adjusted based on the content of catechins contained in the green tea extract. The content of the extract is adjusted so that the content of catechins contained in the green tea extract is 0.1 to 0.2% (w/w) based on the weight of the oral composition for improving bad breath. can do.

Therefore, the content of the green tea extract is preferably based on the content of catechins contained in the green tea extract, and based on 100 parts by weight of the oral cavity composition for improving bad breath, the content of the catechins is The content may be 0.1 to 0.2 parts by weight.

In the present invention, green tea extract means tea leaf extract.

The tea plant is an evergreen tea tree or evergreen broad-leaved shrub belonging to the Tea plant family, and its scientific name is Camellia sinensis. Known as the place of origin, the mountainous region on the border of Tibet and Sichuan Province in China grows naturally in tropical, subtropical and temperate regions, and is now mainly distributed in Korea, Japan, China, India and Southeast Asia. . There are many varieties of the tea tree, and these varieties differ greatly in shape. The small-leaved species mainly cultivated in China and Japan are shrubs that grow to a height of about 2 to 3 m even under natural conditions. It is Takagi who reaches .

The leaves of the tea tree vary greatly depending on the variety and position, but are mainly long oval with a length of 6 cm to 20 cm and a width of 3 cm to 4 cm. is. The leaves are hard and somewhat thick with a glossy surface. There are differences in leaf color intensity and wrinkles depending on the variety. The undersides of young leaves and seedlings are covered with soft hairs. In South Korea, the wild variety grown in Mt. Jiri (Chile) is the Chinese small-leaved variety, and the cultivated tea is mainly the Japanese Yabukita variety, which is an improved version of the Chinese small-leaved variety.

The green tea extract, ie, tea leaf extract, may be prepared according to a general method for preparing plant extracts. More specifically, a solvent extraction method, a supercritical extraction method, or an ultrasonic extraction method is performed on tea tree leaves from which impurities have been removed, the tea tree leaf pulverized material, or the dry material of the tea tree leaf pulverized material. It may be extracted by In this sense, the extract may be a solvent extract extracted with an extraction solvent, a supercritical extract, ie an extract through supercritical extraction with a supercritical fluid, or an ultrasonic extract.

The solvent extract may be prepared using a common solvent, specifically an extraction solvent, under common temperature and pressure conditions according to common methods known in the art.

The extraction solvent is any one selected from the group consisting of water, an organic solvent, or a mixed solvent thereof, preferably water, an alcohol having 1 to 5 carbon atoms, and a mixture thereof, which can be used for extracting natural products, more preferably. can be water. The organic solvent includes linear or branched alcohols having 1 to 5 carbon atoms such as methanol and ethanol, polar solvents such as ethyl acetate or acetone, nonpolar solvents such as hexane or dichloromethane, and ketones having 3 to 5 carbon atoms. A neutral solvent or a mixed solvent thereof may be used, preferably a straight or branched chain alcohol solution having 1 to 5 carbon atoms such as 30 to 90% ethanol, or 30 to 90% carbon atoms 3 to 5 ketone, more preferably 50-80% ethanol aqueous solution or 50-80% acetone aqueous solution, more preferably 60-75% ethanol aqueous solution.

The extraction solvent can be replaced by other common solvents known to those skilled in the art that can exhibit substantially the same effect.

The supercritical extract may be obtained by supercritical extraction or supercritical fluid extraction using carbon dioxide as a fluid under supercritical conditions of reduced pressure and high temperature. In general, supercritical fluids have the properties of liquids and gases when gases reach a critical point under high temperature and pressure conditions. Effective for extracting soluble substances. Specifically, the carbon dioxide becomes a supercritical fluid having properties of liquid and gas at the same time through a process in which the pressure and temperature reach a critical point due to the operation of the supercritical fluid device, and as a result, solubility in fat-soluble solutes increases. Therefore, when the supercritical carbon dioxide passes through the extraction container containing a certain amount of the sample, the fat-soluble substances contained in the sample are extracted by the supercritical carbon dioxide, and after the fat-soluble substances are extracted, they remain in the extraction container. By passing supercritical carbon dioxide containing a small amount of co-solvent again through the sample, it is possible to extract the components that were not extracted with pure supercritical carbon dioxide.

From this aspect, the supercritical fluid used in the supercritical extraction method may be supercritical carbon dioxide or a mixed fluid obtained by mixing carbon dioxide with a co-solvent. The co-solvent may be any one selected from the group consisting of chloroform, ethanol, methanol, water, ethyl acetate, hexane, diethyl ether and mixtures thereof.

Since the carbon dioxide used in the extraction process volatilizes into the air at room temperature, the extract obtained by the above method can be used as a cosmetic composition. can be done.

The ultrasonic extract means extracted by an ultrasonic extraction method. The ultrasonic extraction method is an extraction method that utilizes energy generated by ultrasonic vibrations. When the ultrasonic waves are transmitted to the sample in the extraction solvent, the temperature rises due to the ultrasonic waves. The local temperature increases the kinetic energy of the surrounding reactant particles, so that sufficient energy is available for the reaction, and the impact effect of the ultrasonic energy induces a high pressure to be contained in the sample. It enhances the mixing effect of the substance and the extraction solvent, thus increasing the extraction efficiency.

The extraction solvent that can be used in the ultrasonic extraction method may be any one selected from the group consisting of chloroform, ethanol, methanol, water, ethyl acetate, hexane, diethyl ether, and mixtures thereof.

The solvent extraction method may be cold extraction, digestion extraction, pressure extraction or reflux extraction.

In addition, after performing the extraction process, the extract may be subjected to vacuum filtration, or may be additionally concentrated and/or freeze-dried to concentrate, or the solvent may be removed. Therefore, the tea tree leaf extract in the present invention consists of a dried extract dried by a conventional method, a concentrate of an extract concentrated by a conventional method, and a diluted extract, dried extract or concentrate. Used in the sense of including liquid. The obtained tea leaf extract can be stored in a deep freezer until use.

In addition, the oral cavity composition for improving halitosis includes polyol, polymer, solubilizer, antibacterial component, halitosis removing active component, gum disease preventive component, pH adjuster, preservative, antiseptic, flavoring agent, sweetener, flavoring agent. , a pigment, and a solvent.

A person skilled in the art can easily select and add to the oral cavity composition for improving bad breath of the present invention, in addition to the above active ingredients, auxiliary components contained in oral compositions commonly used in the art.

The solubilizer means a surfactant used to solubilize a substance that is insoluble in water, and examples thereof include anionic surfactants, amphoteric surfactants and nonionic surfactants. Examples include amide nonionic surfactant, sodium lauryl sulfate, polyoxyethylene-polyoxypropylene copolymer (poloxamer), polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, taurate It may also be an anionic surfactant such as a betaine-based amphoteric surfactant.

The antibacterial component is a substance having antibacterial activity, and means a component having antibacterial activity against caries, periodontitis-causing bacteria, gingivitis-causing bacteria, and the like. Examples include sodium chloride, which can exert a strong osmotic effect, and natural extracts with antibacterial activity against the above-mentioned caries-causing bacteria, periodontitis-causing bacteria, and gingivitis-causing bacteria. extracts, bellflower concentrated extracts, yellow oak concentrated extracts, peppermint extracts, pine needle extracts, willow extracts, seaweed extracts or ingredients derived from natural extracts, examples include triclosan, curcumazan triza oil, cetyl chloride It may be, but not limited to, pyridinium chloride, benzothonium chloride, benzalconium chloride or cetylpyridinium chloride or chlorohexidine gluconate. . The antibacterial component may be contained in an amount of 0.01 to 10 parts by weight or 0.05 to 5 parts by weight based on 100 parts by weight of the oral composition for improving bad breath, but is not limited thereto.

The halitosis-removing active ingredients may be non-fermented sugar alcohols, natural extracts, inorganic compounds, enzymes, enzyme inhibitors, and the like. .

The non-fermentable sugar alcohols include xylitol, sorbitol, erythritol, mannitol, maltitol, lactitol, palatinitol, palatinose, oligo sugar (oligosaccharide), etc., the natural extract may be persimmon leaf extract, Sanguinaria extract, peony bark extract, etc.; compounds include zinc chloride, copper gluconate, tetrasodium pyrophosphate (TSPP), sodium acid pyrophosphate (SAPP), sodium hexametaphosphate (SAPP) hexametaphosphate, SHMP) , sodium tripolyphosphate (STP), sodium potassium tripolyphosphate (SKTP), tetrapotassium pyrophosphate (TKPP), sodium metapolyphosphate (acidics odium meta-polyphosphate), sodium acid polyphosphate ( The enzyme may be dextranase, glucose oxidase, glucose peroxidase, lactoperoxidase, glucanase. canase), It may be a protease or lysozyme, and the enzyme inhibitor may be an inhibitor of enzymes involved in oral halitosis generation, such as peptides inhibitors and collagenase inhibitors. .

The above-mentioned active ingredients for removing bad breath can be used alone or in combination of two or more.

The active ingredient for removing bad breath can be added at a concentration of 0.001 to 30% by weight or 0.01 to 10% by weight based on the weight of the oral composition for improving bad breath.

The gum disease preventive ingredient may be sodium chloride, tocopherol acetate, pyridoxine hydrochloride, allantoin, allantoin chlorhydroxyaluminum, tranexamic acid or aminocaproic acid.

The gum disease-preventing component can be used alone or in combination of two or more.

The component for preventing gum disease may be added at a concentration of 0.001 to 30% by weight or 0.01 to 10% by weight based on the weight of the oral cavity composition for improving halitosis.

The pH adjuster means a substance for adjusting pH or buffering changes in pH for pH-sensitive active ingredients, such as antibacterial ingredients and medicinal substances. The pH adjuster includes sodium phosphate, disodium phosphate, trisodium phosphate, sodium citrate, sodium bicarbonate, sodium pyrophosphate, citric acid, malic acid, succinic acid, acid), tartar acid, formic acid or lactic acid.

The pH adjusters may be used alone or in combination of two or more.

The pH adjuster may be added in a concentration of 0.001 to 30% by weight or 0.01 to 10% by weight based on the weight of the oral composition for improving bad breath.

The flavoring agent is a component that is added for the purpose of imparting freshness to the oral cavity composition for improving bad breath, suppressing unclean odors, and improving usability and palatability. Examples include ginseng extract, Propolis extract, mandarin orange oil, L-menthol, cool mint scent (HF-61399), mint scent flavoring agent or mixed flavoring (apple scent, HF-30630) may be used.

The sweetening agent is a component that is added for the purpose of imparting a certain degree of sweetness to the oral cavity composition for improving bad breath and imparting a refreshing feeling. Glycosides, xylitol, D-Xylose, glycyrrhizic acid, chamomile extract, sage extract or propolis extract.

Edible flavors are used as the flavor, and examples thereof include Mentol, Anetol, Eugenol, Limonene, Ocimene, and n-Dodecyl Alcohol. , Citronellol, α-Terpineol, Methyl salicylate, Methyl Acetate, Citronellyl Acetate, Cineol, Linalool, Ethyllina Roll ( Ethyl Linalool), Vanillin, Thymol, Spearmint Oil, Sage Oil, Rosemary Oil, Cinnamon Oil, Peppermint Oil, Eucalyptol Oil or Fruit Extracts may be

Food coloring is mainly used as the coloring matter.

The solvent may be, for example, water or an organic solvent, preferably water or an aqueous ethanol solution, and more preferably water.

In addition, the oral composition for improving halitosis according to an embodiment of the present invention may also include other additives that can be added to the oral composition for improving halitosis.

The oral composition may be, but is not limited to, a mouthwash or mouthwash, and may be manufactured in liquid form to facilitate gargling.

[Production Example: Production of Active Ingredient of Oral Composition for Improving Bad Breath]

Chitosan and green tea extract, which are active ingredients, were prepared in order to prepare an oral cavity composition for improving bad breath.

First, chitosan is prepared by adding high-molecular-weight chitosan to 0.5% acetic acid and dissolving it, and then reacting the chitosan acetate solution with a chitosan-degrading enzyme to adjust the decomposition time so that the molecular weight is moderate. The average molecular weight of the chitosan solution treated with the degrading enzyme for each time was measured using GPC, and the weight average molecular weight (MW) was 108,210 Da, 55,130 Da, 11,170 Da, 5,208 Da and 815 Da, respectively. Chitosan was obtained.

In addition, since the degree of palatability due to the addition of the green tea extract is affected by the astringency of the catechins, green tea extract powder containing 20% catechins was purchased and used.

The purchased green tea extract was added to the mouthwash, and the concentration of green tea extract was 0.1% (w/w, catechin content 0.02% w/w), 0.3% (w/w). , catechin content 0.06% w/w), 0.5% (w/w, catechin content 0.1% w/w), 1% (w/w, catechin content 0.2% w/w) w) was used by adjusting the amount of green tea extract added.

Hereinafter, embodiments of the present invention will be described in detail so that a person having ordinary knowledge in the technical field to which the present invention belongs can easily implement them. This invention may, however, be embodied in many different forms and the examples set forth herein are intended to be illustrative of the invention and should not be construed as limiting the invention. .

In this experiment, the same experiment was repeated three or more times, and the data obtained from each experimental result was averaged using SPSS/WIN 12.0 version statistical program (Statistical Package for social Science, IBM, USA) and mean deviation (Mean±SEM). To test for inter-group significance, analyzes were performed through one-way ANOVA, and Post-Hoc test was P by Duncan's multiple range test. Significance between each experimental group was verified at the <0.05 level.

[Experimental example: Confirmation of bad breath improvement effect by active ingredients]

Experimental example 1-1. Confirmation of the amount of active ingredient to be added according to taste

In the case of oral compositions, the effect of removing bad breath is important, but since various products can be selected according to the taste and preference of the user, the content of the active ingredient is adjusted by adding the degree of preference according to the amount of the active ingredient added. confirmed.

The oral composition used in the experiment used purified water as a solvent in addition to the active ingredient, and menthol (0.05% (w / w)) in addition to green tea extract (Table 1) and chitosan (Table 2). , xylitol (3% (w/w)) and polyoxyethylene hydrogenated castor oil (0.05% (w/w)) were further added. Chitosan having an average molecular weight of 11,170 Da was used as the chitosan.

The preference survey based on the amount of active ingredient added to the manufactured oral composition selects 10 adult males and females who have undergone training based on sensory experiments without oral diseases and other diseases that may affect the experiment, Using each oral composition, overall palatability was measured using a 5-point scale. A score of 5 means the best, and a score of 1 means that the astringent taste is very strong and not very good. The measurement results are shown in Table 3 below.

As shown in Table 3, when the content of green tea extract and chitosan increases, the astringent taste becomes stronger and the overall palatability decreases, especially when the content exceeds a certain level. confirmed that strong astringency significantly reduces palatability. Based on the above results, in the case of green tea extract, when it is added at 1.5% or more (0.3% (w/w) based on catechin content), it is judged that it is difficult to use due to its very strong astringency. When 1.0% or less of green tea extract is added (0.2% (w/w) based on catechin content), a certain level or more of palatability can be secured, and green tea extract is 1.0%. The use of the following was assessed as required.

In the case of chitosan, if it is added in an amount of 0.15% or more, it is judged to be difficult to use due to its very strong astringency. It was judged to be restrictive, and when chitosan was added in an amount of 0.05% or less, a certain level or more of palatability could be ensured, and chitosan was evaluated to be required to be used in an amount of 0.05% or less.

Experimental example 1-2. Confirmation of halitosis control effect by chitosan molecular weight

Based on the addition amount confirmed in Experimental Example 1-1, the bad breath control effect of each active ingredient was confirmed. First, the oral cavity composition shown in Table 4 below was used to confirm the halitosis control effect of chitosan molecular weight.

In order to confirm the halitosis control effect of the prepared oral composition, 10 adult males and females without oral diseases and other diseases that could affect the experiment were selected to check for changes in halitosis. Specifically, every 2 hours, the experimental group used a halitosis meter (Oral Chroma CHM-2, South Korea) was used to measure halitosis values using the halitosis-causing substances (hydrogen sulfide (H ₂ S), methyl mercaptan (CH ₃ SH), dimethyl sulfide ((CH ₃ ) ₂ S)) in the same manner as in FIG. The results are shown in Tables 5 to 7. The reduction rate in Tables 5 to 7 below indicates the extent to which the content of halitosis components after use compared to before use decreased.

As shown in Tables 5 to 7, when chitosan was used, the effect of removing bad breath was confirmed compared to the control group, but it was confirmed that the effect of removing bad breath was different depending on the average molecular weight of chitosan. In particular, in the case of 11,170 Da, which was confirmed to be the most effective, the suppression effect was improved by about 175% or more compared to 815 Da, and it was confirmed that it was improved by about 46% or more compared to 108,210 Da. , was confirmed to be improved nearly 9 times compared to the control group. Therefore, it was confirmed that chitosan with an average molecular weight of 11,170 Da is most preferable for using chitosan for mouthwash.

Experimental example 1-3. Confirmation of halitosis control effect by chitosan molecular weight

In the same manner as in Experimental Example 1-2, the oral cavity composition shown in Table 8 below was used to confirm the effect of controlling bad breath depending on the amount of green tea extract.

In order to confirm the halitosis control effect of the prepared oral composition, 10 adult males and females without oral diseases and other diseases that may affect the experiment were selected and treated as in Experimental Example 1-2. The presence or absence of change was confirmed, and the results are shown in Tables 9 to 11 below. The reduction rate in Tables 9 to 11 below indicates the degree of reduction in the content of halitosis components after use compared to before use.

As shown in Tables 9 to 11, when the green tea extract was used, the effect of removing halitosis was improved compared to the control group. The difference between the addition and the addition of 1.0% is limited, and it was confirmed that the addition of 0.5% is more effective in removing bad breath. In particular, unlike 0.5%, which was confirmed to be the most effective, it was confirmed that the degree of preference decreased sharply at 1.0%, as described in Experimental Example 1-1 and Table 3. It was confirmed that the content of green tea extract contained in the oral cavity composition is most preferably 0.5% (w/w).

Experimental example 1-4. Confirmation of halitosis control effect by green tea extract and chitosan molecular weight

Based on the results obtained in Experimental Examples 1-2 and 1-3, the combined use of green tea extract and chitosan was confirmed to be effective in controlling halitosis. Halitosis control effects were confirmed using the oral compositions shown in Table 12 below.

In order to confirm the halitosis control effect of the oral cavity composition prepared above, 10 adult males and females without oral diseases and other diseases that could affect the experiment were selected, and Experimental Examples 1-2 and 1-3 were selected. The presence or absence of change in bad breath was confirmed as described above, and the results are shown in Tables 13 to 15 below. The reduction rate in Tables 13 to 15 below indicates the degree of reduction in the content of halitosis components after use compared to before use.

As shown in Tables 13 to 15 above, when green tea extract and chitosan were used in combination, the effect of removing bad breath was significantly improved in general, but the tendency according to the molecular weight of chitosan was not observed in experiments without green tea extract. It was confirmed that the green tea extract showed the same tendency as in Example 1-2 and did not affect the effect of removing halitosis due to chitosan molecular weight. Specifically, in the case of 11,170 Da, which was confirmed to be the most effective, the suppression effect was improved by about 58 or more compared to 815 Da, and it was confirmed that it was improved by about 21% or more compared to 108,210 Da. It was confirmed that it was improved by about 8 times compared to the control group. Therefore, it was confirmed that chitosan with an average molecular weight of 11,170 Da is most preferable for using chitosan for mouthwash, even when used in combination with green tea extract.

Experimental example 1-5. Confirmation of protein waste removal effect by green tea extract and chitosan

Based on the results confirmed in Experimental Examples 1-2 to 1-4, an oral composition containing 0.5% green tea extract and 0.05% chitosan having an average molecular weight of 11,170 Da was used. After gargling for 30 seconds, the effect of removing proteolytic by-products in the oral cavity, ie protein waste products, was confirmed. In order to confirm the adsorption and discharge of the proteolytic by-products in the oral cavity, the caramel pigment was dissolved in a mouthwash. Protein degradation by-products were identified. The experimental results are shown in FIG.

As shown in FIG. 2, when an oral composition containing 0.5% of green tea extract and 0.05% of chitosan having an average molecular weight of 11,170 Da was used, gargling for 30 seconds and then spitting out It was confirmed that significantly more proteolytic by-products in the oral cavity were removed compared to

From the above results, it was confirmed that the oral composition of the present invention can effectively control halitosis by removing proteolysis by-products in the oral cavity.

Although the present invention has been described with reference to one embodiment, this is merely an example and a person of ordinary skill in the art will appreciate various modifications and equivalent implementations thereof. It will be appreciated that examples are possible.

Since the present invention uses chitosan and green tea extract, which are natural products, as main ingredients, the use of synthetic compounds that are harmful to the human body can be minimized. Although it is highly effective, it does not cause inconvenience such as astringent taste when used, and has an excellent degree of palatability, and has the effect of improving the feeling of use and satisfaction of consumers. can be used as an object.

Claims (4)

An oral composition for improving bad breath containing chitosan and green tea extract as active ingredients,
An oral cavity composition for improving bad breath, wherein the chitosan has a weight average molecular weight (Mw) of 10,000 Da to 57,000 Da. Claim 1, wherein the oral composition for improving halitosis contains 0.01 to 0.05 parts by weight of chitosan based on 100 parts by weight of the oral composition for improving halitosis. The oral cavity composition for improving bad breath according to . The green tea extract may contain catechins,
The content of the green tea extract is based on the content of catechins contained in the green tea extract, and based on 100 parts by weight of the oral cavity composition for improving bad breath, the content of the catechins is 0.5 parts by weight. The composition for improving bad breath according to claim 1, wherein the ratio is 1 to 0.2. The oral cavity composition for improving halitosis includes polyol, polymer, bactericide, solubilizer, antibacterial ingredient, halitosis-removing active ingredient, gum disease-preventing ingredient, pH adjuster, preservative, antiseptic, flavorant, sweetener, 2. The composition for improving bad breath according to claim 1, further comprising at least one additional ingredient selected from the group consisting of perfumes, pigments and solvents.