JP2627445B2 - Cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to a non-woven fabric comprising a stable combination of a higher fatty acid ester of ascorbic acid, which is useful as a cosmetic, more specifically, a whitening cosmetic and a skin anti-aging cosmetic. It relates to water-based cosmetics.

[Conventional technology]

Higher fatty acid esters of ascorbic acid have been
It is often used in cosmetics because it has the effect of improving skin whitening, such as the improvement of spots and freckles, and the action of promoting the production of skin collagen, preventing fine lines, and maintaining elastic skin. .

[Problems to be solved by the invention]

However, higher fatty acid esters of ascorbic acid are light,
It has the disadvantage that it is oxidized by the action of heat, acid, base or oxygen, or is susceptible to hydrolysis in the presence of moisture. And once such a change occurs, the effective concentration of ascorbic acid higher fatty acid ester decreases, and not only the effect is reduced, but also coloring, off-flavor, etc. occur.
You lose product value.

In order to stably blend the higher fatty acid ester of ascorbic acid into cosmetics, various measures have been taken to prevent contact with moisture and air and to remove other decomposition promoting substances.

For example, a method of coating a higher fatty acid ester of ascorbic acid with an oily substance (JP-A-59-44327), a method of coexisting an antioxidant (JP-A-61-130206), protection as an inclusion compound of cyclodextrin (Japanese Patent Application Laid-Open No. Sho 55-64511). Also, a method of hermetically packaging for each use amount such as a medicine (Japanese Patent Application Laid-Open No.
No. 130206) has also been proposed.

However, there have been problems that the storage stability of higher fatty acid esters of ascorbic acid has not yet been sufficiently solved, or that the ease of use has been sacrificed.

[Means for solving the problem]

Under these circumstances, the present inventors have conducted intensive studies to solve the above problems, and as a result, blended fats and oils and specific powders with higher fatty acid esters of ascorbic acid, and converted them into aluminum single-layer tubes. By filling, it was found that a cosmetic having excellent storage stability and feeling of use of ascorbic acid higher fatty acid ester was obtained, and the present invention was completed.

That is, the present invention relates to the following components (A) to (C): (A) higher fatty acid ester of ascorbic acid, (B) solid fat or semi-solid fat or a mixture thereof, (C) zinc oxide, kaolin and talc. An object of the present invention is to provide a cosmetic comprising one or more selected powders and filled in an aluminum single-layer tube.

Ascorbic acid higher fatty acid ester (A) used in the present invention includes ascorbic acid and C8-C8.
Mono-, di- or triesters with 24 higher fatty acids or mixtures thereof. Particularly preferred specific examples include monopalmitate, dipalmitate, tripalmitate, monostearate, distearate, tristearate, diisopalmitate, diisostearate, and dioleate of ascorbic acid. The content of the ascorbic acid higher fatty acid ester is preferably 0.1 to 20% by weight (hereinafter simply referred to as%), particularly preferably 0.5 to 5%.

Next, as the solid fat or semi-solid fat (B), those used in the field of cosmetics or quasi-drugs,
There is no particular limitation as long as it can effectively dissolve and disperse the ascorbic acid fatty acid ester, but those having low water affinity are preferred. Specifically, solid paraffin, vaseline, azochelite, ceresin, icrocrystallin wax, mokurou, beeswax, carnauba wax, whale wax, candelilla wax, etc., or one or a combination of two or more thereof are particularly preferred. The use amount of the component (B) is preferably 50 to 98.9%, particularly preferably 75 to 98.%.

The powder (C) used in the present invention is one or more powders selected from zinc white, kaolin and talc.

Usually, the powder to be blended in the ointment is dispersed in the ointment to control the hardness of the ointment and act for the purpose of enhancing the feeling of use. However, most of the many powders used in the cosmetic or quasi-drug field promoted the decomposition of higher fatty acid esters of ascorbic acid and caused coloring. On the other hand, it has been found that only the component (C) of the present invention specifically enhances the feeling of use of the ointment and is excellent in stabilizing the higher fatty acid ester of ascorbic acid. The amount of component (C) used is 0.1-20%, especially 1-1.
0% is preferred.

The container for filling the cosmetic of the present invention is an aluminum single-layer tube. In the present invention, since the higher fatty acid ester of ascorbic acid is blended, it is necessary to shield the cosmetic composition of the present invention from air, moisture, light, and the like that cause the higher fatty acid ester of ascorbic acid to decompose and deactivate. Although it is necessary to minimize the contact with air and the like even in the case of repeated use, surprisingly, only a single-layer tube container was suitable for this purpose.

This means that even with the same tube-type container, the shape-return type has the advantage that the contact area with air at the time of opening the container is small, but after extruding the ointment, the air returns to the original shape when the tube returns to its original shape. Is inhaled, which is considered to adversely affect quality maintenance thereafter. Further, even if the tube material contains aluminum (for example, aluminum five-layer tube), the result is not always good, and the material that comes into contact with the composition according to the present invention inside the container affects quality maintenance. It is also suggested.

In addition, liquid oils and fats, preservatives, fragrances, pigments, and the like can be added to the cosmetic of the present invention as long as the effects of the present invention are not impaired.

〔Example〕

 Next, the present invention will be described with reference to examples.

Example 1 A composition having the following formulation was prepared and filled in an aluminum monolayer tube.

Ascorbic acid dipalmitate 2.0% Vaseline 92.5% Microcrystalline wax 1.0% Beeswax 1.0% Zinhua 3.0% Flavor 0.5% Total 100.0% Example 2 A composition having the following formulation was prepared and filled in an aluminum single-layer tube. .

Ascorbic acid monostearate 2.0% Vaseline 89.5% Microcrystalline wax 2.0% Whale wax 2.0% Talc 4.0% Flavor 0.5% Total 100.0% Example 3 A composition having the following formulation was prepared and filled in an aluminum single-layer tube. .

Ascorbic acid dipalmitate 1.0% Vaseline 65.5% Beeswax 8.0% Canterilla wax 5.0% Liquid paraffin 5.0% Jojoba oil 5.0% Zinc flower 10.0% Flavor 0.5% Total 100.0% Test example 1 As powder in the formulation of Example 1 Talc (Example 4), kaolin (Example 5), mica (Comparative Example 1), bentonite (Comparative Example 2), titanium oxide (Comparative Example 3), and nylon powder (Comparative Example 4) instead of zinc white. The formulated composition was prepared, filled in an aluminum single-layer tube, and subjected to a storage stability test.

That is, the properties of the product after storage at 40 ° C. for 4 months were observed, and the residual amount of ascorbic acid higher fatty acid ester after storage for 1 month, 2 months and 6 months was quantified. Table 1 shows the results.

Test Example 2 The composition of the formulation of Example 1 was filled into an aluminum single-layer tube or a tube of various materials, and a storage stability test was performed.

That is, the residual amount of ascorbic acid higher fatty acid ester in the composition when stored at 40 ° C. for 1 month, 2 months, and 6 months was quantified. Table 2 shows the results.

Test Example 3 A test of the whitening effect of the ointment containing ascorbic acid higher fatty acid ester produced in Example 1 (period 1 month to 10 months) for 10 patients and men and women with pigmentation spots on the cheeks Was done. The whitening effect can be measured using a color difference meter (Nippon Denshoku Industries Co., Ltd.) before and after using this ointment by measuring the brightness of the pigmented site (A) and the non-pigmented site (B) on the right and left cheeks of the patient
DP-1001D), and the average value of the difference (AB) between the left and right pigmented sites and the non-pigmented site was determined. Table 3 shows the results
Shown in The difference in brightness between the left and right pigmented sites and the non-pigmented sites was significantly reduced.

Test Example 4 The cosmetic preparation of the present invention prepared in Example 1 was applied to the back skin of a shaved guinea pig for 10 days, and tested for transdermal absorption and skin collagen synthesis.

In the percutaneous absorption test, the skin at the site of application 4 hours after the final application was collected, and stained with reduced ascorbic acid by the Sosa method. In the skin collagen synthesis test, the skin at the application site was collected and minced, eluted with 0.15 M and 0.5 M NaCl, dialyzed, and the soluble collagen fraction was separated. The residue was also dialyzed to obtain an insoluble collagen fraction. After freeze-drying both fractions, each fraction was hydrolyzed with HCl, and hydroxyproline was quantified by the kivirikko-Prockopf method.

As a result, it was found that ascorbic acid dipalmitate was present in the skin as reduced ascorbic acid in which the ester was released in the epidermis, and was absorbed percutaneously. Table 4 shows the results of the skin collagen synthesis test.
Shown in It was found that when the cosmetic of the present invention was applied, soluble collagen, ie, procollagen, increased, and collagen synthesis in the skin was promoted.

[Effects of the Invention] The cosmetic of the present invention has an excellent whitening effect, an effect of promoting the synthesis of collagen related to the prevention of skin aging, and an excellent feeling in use, and the long-term storage of ascorbic acid higher fatty acid esters. It is easy to use without losing its effect.

Claims (1)

(57) [Claims] 1. The following components (A) to (C): (A) higher fatty acid ester of ascorbic acid, (B) solid fat or semi-solid fat or a mixture thereof, (C) zinc white, kaolin and talc A cosmetic comprising one or more selected powders and filled in an aluminum single-layer tube.