JP2998236B2 - How to control fragrance and fragrance - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a fragrance and a method for controlling a fragrance which can be effectively used for aromatherapy (aroma therapy).

[0002]

2. Description of the Related Art In recent years,
In the overcrowded and complicated modern society, the adverse effects on the human body due to the addition of stress are being addressed. Under such circumstances, various researches have been conducted, including research on amenity measures to make a living space comfortable, development of related substances, and further, odor control measures. In particular, aroma greatly affects human physiology and psychology. Aromatherapy (aroma therapy) using the effects of herbs, potpourri, phytoncide (forest bathing), etc. Research in various fields, such as chemistry, has become active.

Therefore, development of perfume products that can be used for aromatherapy and the like is progressing, but it is difficult to control the emission of fragrance, and therefore, there has been a problem of fine adjustment of fragrance emission.

[0004]

The present inventors have made intensive studies to solve the above-mentioned problems, and as a result, coated a fragrance with a material whose solubility can be changed depending on pH in a solution state. When the pH of the solution is changed, the solubility of the coating material changes, the release amount of the fragrance is easily adjusted, and the fragrance can be finely adjusted, and in this case, the fragrance, the type of the coating material, By changing the amount used and the rate of addition of the pH controlling substance, it is possible to change the degree of release of the scent in various ways and to give different scents over time, and such a method for adjusting the scent can be effectively used for aromatherapy and the like. And found the present invention.

[0005] Accordingly, the present invention provides a method for preparing a solution,
Perfume coated with a material whose solubility changes depending on
a fragrance characterized by comprising a pH adjuster,
And changing the liquidity of a solution containing a fragrance coated with a material whose solubility changes depending on the pH in a solution state with a pH adjuster, thereby adjusting the release amount of the fragrance. Provides an adjustment method.

Hereinafter, the present invention will be described in more detail. As the fragrance used in the fragrance of the present invention, any fragrance that emits fragrance can be used. For example, natural animals and plants are used as a source and are included in them. Oxidation and reduction of fragrant components to natural fragrances extracted by physicochemical treatment such as steam distillation and extraction, chemical substances derived from resources such as coal, petroleum, natural gas, oils and fats, natural fragrances and isolated fragrances Perfume produced by giving an arbitrary chemical reaction such as condensation, hydrolysis, substitution, addition, rearrangement and the like. Specific examples of such fragrances include animal fragrances such as scented incense, spirit cat incense, sea cat incense, dragon scent, sandalwood oil, neroli oil, bengamot oil, lemon oil, lavender oil, hilip oil, sage oil, Rosemary oil, peppermint oil, eucalyptus oil, verbena oil,
Citronella oil, Kayabute oil, Salvia oil, Clove oil,
Vegetable flavors such as basil oil, camomill oil, sandalwood oil, Costas oil, labdanum oil, brome extract, carrot seed extract, jasmine extract, mimosa extract, narcissus extract, olibanium extract, rose extract, etc. , Acetophenone, dimethylindan derivative, naphthalene derivative, allyl caprate, α-amylcinamic aldehyde, anesole, anisaldehyde, benzyl acetate, benzyl alcohol, benzyl propionate, borneol, butyl acetate, butyl butyrate, camphor, carbone, Cinnamyl acetate, cinnamyl alcohol, citral citronellol,
Cuminaldehyde, cyclamelaldehyde, cyclopentane decanolide, decanol, ethyl butyrate, ethyl caprate, ethyl cinnamate, ethyl vanillin, ethyl brassylate, eugenol, geraniol, hexenol, α-hexylcinnamic aldehyde, hydroxycitrone Lal, indole, isoamyl acetate, isoamyl isovalerate, isoeugenol, linalool, linalyl acetate, p-methylacetophenone, methylanthranilate, methyldihydrojasmonate, methyleugenol, methyl-β
Naphthol ketone, methylphenylcarbinyl acetate, musketol, muskoxylol, 2,6-nonadinol, γ-nonalactone, phenylacetaldehyde dimethyl acetate, β-phenylethyl alcohol, 3,3,5-trimethylcyclohexanol, γ
-Chemical substances such as undecalactone, undecenal, and vanillin are exemplified. These flavors may be used alone or as a mixture of two or more.

Further, the amount of the fragrance is 0.0% of the whole fragrance.
1 to 50% (% by weight, hereinafter the same), particularly 0.1 to 30%
It is preferable that

[0008] Next, the material coated with the fragrance changes in solubility depending on pH in a solution state.
For example, a material that does not dissolve at or near neutrality but dissolves when the liquidity is made acidic or alkaline. Specific examples of such a coating material include aminoalkyl methacrylate copolymer, methacrylic acid copolymer, hydroxypropylmethylcellulose phthalate, hydroxypropylmethylcellulose acetate succinate,
Examples include enteric coating agents such as carboxymethylethylcellulose and cellulose acetate phthalate (dissolved in alkaline), and gastric coating materials such as polyvinyl acetal diethylaminoacetate (dissolved in acidic). In addition, the coating of the fragrance with the coating material can be performed by a usual method.

The amount of the coating material used is 0.5 to 30.
%, Particularly preferably 3 to 15%. If it is less than 0.5%, it may not be possible to form a sufficient film thickness, and it may disintegrate immediately after being put in water, and if it exceeds 30%, it has a fragrance. Release may be significantly delayed.

The pH-adjusted material used in the present invention is for changing the solubility of the coating material. As the pH adjuster, any acid adjuster or alkali adjuster or a mixture thereof can be used. Examples of the acid adjuster include mineral acids such as hydrochloric acid, sulfuric acid, boric acid, and silicic acid, formic acid, and citric acid. Organic carboxylic acids such as acid, trichloroacetic acid, trifluoroacetic acid, benzoic acid, fumaric acid, and tartaric acid; and sulfonic acids such as methanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, mesitylenesulfonic acid, and naphthalenesulfonic acid. Can be Also,
Examples of the alkalinity adjusting substance include alkali metal salts such as sodium and potassium, alkaline earth metal salts such as calcium and magnesium, and ammonium salts, such as sodium chloride, sodium hydrogen carbonate, sodium carbonate, borax, sodium sulfate, and potassium sulfide. , Sodium sulfide,
Sodium sesquicarbonate, calcium oxide, potassium nitrate, sodium nitrate, calcium nitrate, aluminum sulfate, magnesium carbonate, sodium thiosulfate, sodium polyphosphate, calcium carbonate, calcium hydrogen phosphate, potassium bromide, calcium chloride, ammonium chloride, iron sulfate, Heavy magnesium carbonate, sodium phosphate, sodium thiosulfate, etc., trimethylamine, triethylamine, tributylamine, pyridine, N, N-
Dimethylaniline, N-methylpiperidine, N-methylmorpholine, diethylamine, cyclohexylamine,
Examples include nitrogen-containing organic compounds such as procaine, dibenzylamine, N-benzyl-β-phenethylamine, 1-ephenamine, and N, N′-dibenzylethylenediamine. When a carbonate is used together with the above-mentioned organic acid as an alkalinity adjusting substance, it is possible to prepare the fragrance in a foamed form.

The amount of the pH-adjusted substance can be appropriately increased or decreased according to the scent release speed, time and the like.

The fragrance of the present invention may contain optional components other than the above essential components as long as the effects of the present invention are not impaired. Examples of the optional component include sugars, surfactants, fats and oils, and high molecular compounds. When a solvent is used, water, alcohols such as ethanol and the like are preferably used.

The fragrance of the present invention comprises a fragrance coated with the above-mentioned coating material, a pH-adjusted substance, and the like.
When each component can be mixed in a solution at the time of use, it can be prepared and stored in various forms when not in use. For example, all the components are mixed to prepare a solid single form, or the fragrance coated with the coating material and the pH regulator are separately solidified or the former is solid, and the latter is a solution. Both can be prepared in two separate forms. Specifically, when the fragrance of the present invention is prepared in a single form, pills, tablets (including foams),
It can be formulated into an arbitrary solid preparation such as a capsule to prepare a dissolving fragrance at the time of use. When prepared in two forms, the fragrance coated with the coating material according to a conventional method is used as an arbitrary solid preparation such as pills, tablets, capsules, and the like.
The preparation can be prepared as a liquid preparation, and a solvent can be added as needed at the time of use, and the mixture can be used in a solution.

In the above-mentioned fragrance, the fragrance is coated with a material whose solubility can be changed depending on the pH in a solution state, and the liquid property of the fragrance-containing solution coated with this coating material is adjusted with a pH regulator. By changing, the release of the fragrance of the coated fragrance can be controlled.

In this case, if the pH of the solution is gradually added to the above solution to gradually change the liquidity, the release of the scent can be finely adjusted. Or a means for controlling the pH with a controlled-release material, or coating the pH-adjusted substance with a sustained-release material, specifically, ethylcellulose or the like.

Further, when a plurality of fragrances are used as the fragrance, different fragrances can be enjoyed over time. Specifically, the fragrance is quickly released from the fragrance coated with the coating material at a desired pH, and a fragrance that exhibits normal immediate effect is used in combination with a fragrance in which fragrance release is controlled, and the pH of the solution is adjusted. Is changed over time.

Further, by using a fragrance which affects physiological functions as the fragrance and controlling the release of the fragrance as described above, the fragrance having an opposing or synergistic action over time is released. It can be applied to treatment of psychosomatic disorders, aromatherapy therapy and the like. For example, there are fragrances containing a fragrance for awakening-a fragrance for sleep, a fragrance for promoting appetite-a fragrance for controlling appetite, and these fragrances can also control physiological functions by fragrance.

[0018]

According to the present invention, the release of the fragrance of the fragrance can be adjusted only by changing the liquid property without using a machine or the like, and it is inexpensive in cost and can be used anywhere. Therefore, there is an advantage that the range of application is wide. Furthermore, when a pH adjuster is gradually added or a plurality of fragrances having different scent releasing properties at a desired pH are used, the scent can be finely adjusted with time, and different scents can be enjoyed. Therefore, the method for controlling the fragrance and fragrance of the present invention greatly contributes to aromatherapy, improvement of living environment, and the like.

[0019]

EXAMPLES The present invention will be specifically described below with reference to examples and comparative examples, but the present invention is not limited to the following examples. In the following examples, all parts are parts by weight.

Example 1 <Foamed tablet composition> Sodium bicarbonate 48 parts Citric acid 40 Sodium sulfate 5 Polyethylene glycol 6000 1 d-limonene 6 Lactose 5 Total 105 parts <Enteric coating liquid composition> Eudragit S100 (Remfarm Co., Ltd.) 100 parts polyethylene glycol 6000 10 talc 30 ethanol 1500 total 1640 parts <pH adjusted tablet composition> Borax 20 parts methyl cellulose 10 total 30 parts According to the above effervescent tablet formulation, 6 parts of d-limonene was adsorbed on 48 parts of sodium bicarbonate. Thereafter, 40 parts of citric acid, 5 parts of sodium sulfate, and polyethylene glycol 6000 were added in 1 part.
And 5 parts of anhydrous lactose were added and mixed. This mixture was tableted with a tableting machine at a tableting pressure of 2.5 t / cm ² and a diameter of 10 m
m, 500 mg / tablet were obtained. After leaving one side of the obtained tablet and coating the other side with silicone rubber, the other side is coated with Eudragit using the enteric coating liquid of the above-mentioned formulation to obtain a delayed-release effervescent tablet shown in FIG. Was. In the figures, 1 is a tablet, 2 is a silicone rubber layer,
3 is an Eudragit layer.

Further, according to the above formula, 20 parts of borax and 10 parts of methylcellulose were mixed and tableted to form
A pH-adjusted tablet of 0 mg / tablet was obtained.

Next, the obtained delayed-release effervescent tablet and pH
The adjusted tablet was split using the release test device shown in FIG.
It was evaluated by the trap method. In this case, the release evaluation is 2
Carried out at 5 ° C. conditions, release the experimental apparatus of FIG. 2, 10 cm by the flow meter 5 air flow from the air pump 4 ³ / m
The air was adjusted to "in", and the air was allowed to flow into a 25 ml sample solution 8 placed in a test container 7 (63.6 cm ^{2 in} surface area) through an air inlet tube 6. Further, benzyl acetate released from the sample solution was removed. Air outflow pipe 9
Through the extraction vessel and into an extraction vessel 10 containing acetone as an extraction liquid, and released into the gas phase. As a result of this evaluation, a delayed release pattern of d-limonene was obtained from the delayed-release effervescent tablet as shown in FIG. The amount of d-limonene released into the gas phase was determined by gas chromatography (GC) under the following conditions. <GC analysis conditions> Column: HiCap CBP1-S25-050 (manufactured by Shimadzu Corporation) Detector: Flame ionization detector (manufactured by Shimadzu Corporation) Heating rate: 4 ° C / min Column temperature: 70 to 220 ° C Flow rate: N ₂ , a2kg / cm ² Direct Injection

[Embodiment 2] According to the formulation of the effervescent tablet A, 6 parts of d-limonene was adsorbed on 48 parts of sodium bicarbonate, and then 40 parts of citric acid, 5 parts of sodium sulfate, 1 part of propylene glycol, and 15 parts of anhydrous lactose were added and mixed. Mix the mixture with a tableting machine for 2.5
Tableting with a tableting pressure of t / cm ² , diameter 10 mm, 500 m
g / tablet were obtained. Further, it was coated with an enteric coating solution and silicone rubber in the same manner as in Example 1 to obtain a delayed-release effervescent tablet A.

Further, according to the formulation of the effervescent tablet B, tableting was performed in the same manner as in the case of the effervescent tablet A to obtain an effervescent tablet B at 500 mg / tablet. In addition, the enteric coating was not applied to the effervescent tablet B.

According to the above formula, 10 parts of borax and 10 parts of methylcellulose were mixed and tableted to form
A pH-adjusted tablet of 0 mg / tablet was obtained.

The obtained delayed-release effervescent tablet A, effervescent tablet B and pH-adjusted tablet were put into a release test apparatus shown in FIG. 2 and evaluated. As a result, a pattern of immediate release of benzyl acetate and delayed release of d-limonene as shown in FIG. 4 was obtained.

Example 3 The same effervescent tablet as in Example 1 was tableted, and the same enteric coating solution as in Example 1 was spray-coated using a high coater (manufactured by Freund) to give 582 mg / mg. Enteric-coated tablets were obtained.

From the results of the above Examples and Comparative Examples, it is possible to delay the release of the fragrance component from the effervescent tablet containing the fragrance component according to the present invention. It was found that the lag time and the release rate could be controlled by changing the formulation, the coating amount, and the formulation and composition of the pH-adjusted tablet.

[Brief description of the drawings]

FIG. 1 is a cross-sectional view of a delayed-release effervescent tablet.

FIG. 2 is an explanatory view of a fragrance release experiment apparatus.

FIG. 3 is a graph showing the release behavior of d-limonene from a delayed-release effervescent tablet of Example 1 with a change in pH.

FIG. 4 is a graph showing the release behavior of d-limonene from delayed-release effervescent tablet A and benzyl acetate from effervescent tablet B according to pH change in Example 2.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Effervescent tablet 2 Silicone rubber layer 3 Enteric coating layer (Eudragid layer) 4 Air pump 5 Flow meter 6 Air inflow tube 7 Test container 8 Sample solution 9 Air outflow tube 10 Extraction container

──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-59-20219 (JP, A) JP-A-59-139266 (JP, A) JP-A-62-120315 (JP, A) JP-A-2- 29259 (JP, A) Special Table 2-500598 (JP, A) (58) Fields surveyed (Int. Cl. ⁷ , DB name) A61L 9/01 A61K 7/46

Claims (2)

(57) [Claims] 1. A fragrance comprising a fragrance coated with a material whose solubility changes depending on the pH in a solution state, and a pH regulator. 2. The release amount of a fragrance is controlled by changing the liquidity of a solution containing a fragrance coated with a material whose solubility changes depending on the pH in a dissolved state by using a pH adjuster. How to adjust the scent.