JP4329914B2 - Antiperspirant - Google Patents
Antiperspirant Download PDFInfo
- Publication number
- JP4329914B2 JP4329914B2 JP18060898A JP18060898A JP4329914B2 JP 4329914 B2 JP4329914 B2 JP 4329914B2 JP 18060898 A JP18060898 A JP 18060898A JP 18060898 A JP18060898 A JP 18060898A JP 4329914 B2 JP4329914 B2 JP 4329914B2
- Authority
- JP
- Japan
- Prior art keywords
- antiperspirant
- kojic acid
- present
- sweating
- stickiness
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000001166 anti-perspirative effect Effects 0.000 title claims description 27
- 239000003213 antiperspirant Substances 0.000 title claims description 27
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 claims description 25
- 229960004705 kojic acid Drugs 0.000 claims description 23
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 claims description 23
- 239000004480 active ingredient Substances 0.000 claims description 6
- 230000035900 sweating Effects 0.000 description 18
- 230000000694 effects Effects 0.000 description 12
- 238000001035 drying Methods 0.000 description 10
- 210000004243 sweat Anatomy 0.000 description 10
- 238000012360 testing method Methods 0.000 description 8
- 238000009472 formulation Methods 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 239000007921 spray Substances 0.000 description 6
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000006071 cream Substances 0.000 description 3
- 238000000855 fermentation Methods 0.000 description 3
- 230000004151 fermentation Effects 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 235000019645 odor Nutrition 0.000 description 3
- 229940060184 oil ingredients Drugs 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 208000035985 Body Odor Diseases 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- -1 chlorohydroxyaluminum Chemical compound 0.000 description 2
- 239000002781 deodorant agent Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 229940098458 powder spray Drugs 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 2
- 235000012239 silicon dioxide Nutrition 0.000 description 2
- 239000012798 spherical particle Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 239000011787 zinc oxide Substances 0.000 description 2
- OFSVOTZRHVSJHC-UHFFFAOYSA-N 1,1,2,2,3,3,4,4,5,5-decamethylcyclohexane Chemical compound CC1(C)CC(C)(C)C(C)(C)C(C)(C)C1(C)C OFSVOTZRHVSJHC-UHFFFAOYSA-N 0.000 description 1
- ZUGAOYSWHHGDJY-UHFFFAOYSA-K 5-hydroxy-2,8,9-trioxa-1-aluminabicyclo[3.3.2]decane-3,7,10-trione Chemical compound [Al+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O ZUGAOYSWHHGDJY-UHFFFAOYSA-K 0.000 description 1
- WJLVQTJZDCGNJN-UHFFFAOYSA-N Chlorhexidine hydrochloride Chemical compound Cl.Cl.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WJLVQTJZDCGNJN-UHFFFAOYSA-N 0.000 description 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 1
- DTPLOCBWAFWYND-UHFFFAOYSA-N Cl.C=1C=CC=CC=1C(=O)C(=O)C1=CC=CC=C1 Chemical compound Cl.C=1C=CC=CC=1C(=O)C(=O)C1=CC=CC=C1 DTPLOCBWAFWYND-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 240000006927 Foeniculum vulgare Species 0.000 description 1
- 235000004204 Foeniculum vulgare Nutrition 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 1
- 244000223014 Syzygium aromaticum Species 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- 244000273928 Zingiber officinale Species 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
- HDYRYUINDGQKMC-UHFFFAOYSA-M acetyloxyaluminum;dihydrate Chemical compound O.O.CC(=O)O[Al] HDYRYUINDGQKMC-UHFFFAOYSA-M 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 1
- 229940009827 aluminum acetate Drugs 0.000 description 1
- 229940103272 aluminum potassium sulfate Drugs 0.000 description 1
- GCVCIVDNHNBFMS-UHFFFAOYSA-K aluminum;benzenesulfonic acid;trihydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3].OS(=O)(=O)C1=CC=CC=C1.OS(=O)(=O)C1=CC=CC=C1.OS(=O)(=O)C1=CC=CC=C1 GCVCIVDNHNBFMS-UHFFFAOYSA-K 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- FYBYQXQHBHTWLP-UHFFFAOYSA-N bis(silyloxysilyloxy)silane Chemical compound [SiH3]O[SiH2]O[SiH2]O[SiH2]O[SiH3] FYBYQXQHBHTWLP-UHFFFAOYSA-N 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
- 229960004504 chlorhexidine hydrochloride Drugs 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 238000004332 deodorization Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- ZFSXZJXLKAJIGS-UHFFFAOYSA-N halocarban Chemical compound C1=C(Cl)C(C(F)(F)F)=CC(NC(=O)NC=2C=CC(Cl)=CC=2)=C1 ZFSXZJXLKAJIGS-UHFFFAOYSA-N 0.000 description 1
- 229950006625 halocarban Drugs 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229940046892 lead acetate Drugs 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- 229960000869 magnesium oxide Drugs 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- HMMGMWAXVFQUOA-UHFFFAOYSA-N octamethylcyclotetrasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 HMMGMWAXVFQUOA-UHFFFAOYSA-N 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- GRLPQNLYRHEGIJ-UHFFFAOYSA-J potassium aluminium sulfate Chemical compound [Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRLPQNLYRHEGIJ-UHFFFAOYSA-J 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 229960001922 sodium perborate Drugs 0.000 description 1
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
- 229960001296 zinc oxide Drugs 0.000 description 1
- 229940118827 zinc phenolsulfonate Drugs 0.000 description 1
Landscapes
- Pyrane Compounds (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
【０００１】
【発明の属する技術分野】
本発明は、制汗剤に関するものであり、より詳しくは、コウジ酸および／またはその誘導体を有効成分とし、皮膚に塗布または噴霧することによって、優れた制汗作用を有し、さらに、発汗時のべたつきおよび発汗乾燥後のべたつきのない使用感に優れた制汗剤に関する。
【０００２】
【従来の技術】
本出願人が長年研究を続けてきたコウジ酸およびその誘導体は、色白効果や消炎効果など、種々の優れた特徴をもち、かつ副作用のない有用性の高い薬物として知られており、その有用性は、例えば、特公昭５７−４６８２５号公報、特公昭６１−１０４４７号公報、特公昭５８−３４４４６号公報、特公昭６０−２７６４８号公報、特開昭５５−１５７５０９号公報、特公平６−１６６８５号公報、特公昭６３−２７３２２号公報、特公平６−１３４４８号公報、特開昭６１−１４３３１４号公報、特公平５−３０４２２号公報、特開平１−１３２５０２号公報、特許第２５４９１４８号、特許第２７１２１２６号、特許第２５０４８０５号、特開平３−８６８２１号公報、特開平１０−１７４６８号公報、特開平１０−５９８４７号公報等に開示されている。
【０００３】
ところで、皮脂や汗、角質の代謝などによってもたらされる皮膚上の有機物が細菌によって代謝・分解されることにより臭気物質が発生し、腋臭などの体臭を引き起こすことは知られている。これらの体臭を防止するには、▲１▼発汗の抑制、▲２▼殺菌による皮膚常在菌の抑制、▲３▼発生した臭いの消臭、▲４▼発生した臭いの香料によるマスキングなどの方法が試みられている。
【０００４】
従来より、パウダースプレー、ロールオン、スティック、ジェル、クリームなどの様々なタイプの制汗剤が使用されており、これらは、通常、制汗成分、殺菌成分、消臭成分などと粉体、油成分、界面活性剤やワックスなどからなっている。これらの制汗剤は、使用時、発汗時及び発汗乾燥後にべたつきを生じるという問題点が指摘されており、この問題点を解決するために、無水ケイ酸などの吸汗・吸皮脂効果を有する粉体、球状粒子粉体、シリコーン処理された粉体や、他の油成分より軽い使用感を有するシリコーンを配合したり、清涼感を目的としてエタノール等を中心とした揮発性を有する成分を配合するなどの様々な使用感の改良が試みられている。
【０００５】
【本発明が解決しようとする課題】
しかしながら、これらの方法では、使用直後のべたつきはある程度抑制できるものの、発汗時のべたつきや、発汗後乾燥した後のべたつきに対しては十分な効果が得られなかった。また、球状粒子粉体は使用感向上に効果があるものの、大量に配合すると白浮きしてしまうという問題点もある。このため、発汗時及び発汗後乾燥した後にべたつかない、使用感に優れた制汗剤の開発が望まれていた。
【０００６】
【課題を解決するための手段】
本発明は、上記要望に応えるために開発されたものであり、優れた制汗作用に加え、発汗時のべたつきおよび発汗乾燥後のべたつきを防止する効果を併せ持つ素材を求めて鋭意研究を重ねた結果、コウジ酸および／またはその誘導体が、皮膚に塗布または噴霧することによって上記目的を有効に達成きる新たな知見を得て、かかる知見を元に完成させたものである。
すなわち、本発明によれば、コウジ酸および／またはその誘導体を有効成分とする、優れた制汗作用を有し、さらに、発汗時のべたつきおよび発汗乾燥後のべたつきのない使用感に優れた塗布剤型または噴霧剤型制汗剤が提供される。
【０００７】
【発明の実施の形態】
本発明において使用されるコウジ酸（５−オキシ−２−オキシメチル−γ−ピロン）としては、５−オキシ−２−オキシメチル−γ−ピロンの純品、コウジ酸生産能を有する公知の菌株を培養して得られるコウジ酸を主成分とする発酵液、該発酵液の濃縮液、および該発酵液からコウジ酸を抽出して結晶化したものなどが使用される。
【０００８】
コウジ酸誘導体としては、例えば、特公昭６０−１０００５号公報、特公平１−４５４７２号公報、特公平３−７４２２９号公報、特公昭５８−２２１５１号公報、特公昭５８−２２１５２号公報に開示されているコウジ酸のエステル化物およびコウジ酸の２位の−ＣＨ2 ＯＨ基に糖類を結合させることによって、コウジ酸分子を安定化させたコウジ酸誘導体など公知のものを単独または２種以上を組み合わせて用いることができる。
【０００９】
本発明において、前記コウジ酸および／またはその誘導体を有効成分とする制汗剤は、化粧料、医薬部外品として許容し得る外用の形態で患部に直接噴霧あるいは塗布して使用される。
この場合のコウジ酸および／またはその誘導体の配合量は、製剤全体に対して、０．００１ないし１０重量％、好ましくは０．１ないし５重量％の範囲で配合される。
【００１０】
本発明の制汗剤の剤型は、クリーム、乳液、ローション、エッセンス、ゲル剤、ペースト剤、軟膏、スティック剤及びチンキ剤等の塗布剤型またはエアゾール剤、スプレー剤等の噴霧剤型の形態で幅広く使用に供されるものである。
【００１１】
さらに、本発明の制汗剤を調製する場合、通常に用いられる種々の公知の有効成分、例えば、クロルヒドロキシアルミニウム、酸化亜鉛、アラントインクロルヒドロキシアルミニウム、アラントインジヒドロキシアルミニウム、硫酸アルミニウムカリウム、塩化アルミニウム、Ｐ−フェノールスルホン酸亜鉛、硫酸アルミニウム、クエン酸アルミニウム、酢酸アルミニウム、フェノールスルホン酸アルミニウム、β−ナフトールジスルホン酸アルミニム、酢酸鉛、過ホウ酸ナトリウムなどの制汗成分、トリクロロヒドロキシジフェニルエーテル（トリクロサン）、塩化ベンザルコニウム、塩化ベンゼトニウム、塩酸クロルヘキシジン、グルコン酸クロルヘキシジン、ハロカルバンなどの殺菌成分、酸化亜鉛、酸化マグネシウム、ゼオライト、メタケイ酸アルミン酸、無水ケイ酸などの消臭成分などやケイヒ、チョウジ、ウイキョウ、ショウキョウ、ハッカなどの動物・植物・微生物由来の各種抽出物等を本発明の目的を損なわない範囲で、その時々の目的に応じて適宜添加して使用することができる。さらに、本発明の制汗剤にはこれら公知の有効成分に加え、タルク、無水ケイ酸などの粉体、ジメチルポリシロキサン、メチルフェニルポリシロキサンなどのシリコーンオイルやオクタメチルシクロテトラシロキサン、デカメチルシクロペンタシロキサンなどの環状シリコーンなどの基剤成分のほか、必要に応じて公知の保湿剤、防腐剤、酸化防止剤、キレート剤、ｐＨ調整剤、香料、着色剤等種々の添加剤を本発明の目的を損なわない範囲で併用することができる。
【００１２】
【実施例】
次に実験および処方例を開示して本発明を説明するが、これらの開示は本発明の好適な態様を示すものであって、本発明を何ら限定するものではない。
【００１３】
＜試験例１＞制汗効果
ａ）試験方法
男女１０名を対象に試験を実施した。本発明品であるコウジ酸を含有するエッセンス（処方例７）を右腋下に、そして、対照品としてコウジ酸無配合エッセンス（処方例７からコウジ酸を除いたもの）を左腋下に塗布し、軽い運動をしてもらい、その直後に、各人以下の基準に従って、発汗具合を評価してもらった。
１：汗をかいている
２：少し汗をかいている
３：汗ばんでいる
４：汗をかいていない
ｂ）試験結果
表１に制汗効果結果を示す。
ｃ）考察
コウジ酸無配合の対照品を使用した左腋下では、１０名中１０名が汗をかいたという結果であったのに対し、本発明品を使用した右腋では、１０人中５名が全く汗をかいておらず、残りの５名についても汗ばむ程度の発汗に抑えられていた。この結果からより明らかなように、本発明制汗剤は制汗効果を有することが立証された。
なお、試験期間を通じて副作用は全く認められず、安全性が高いことも認められた。
【００１４】
【表１】
＜試験例２＞発汗時及び発汗乾燥後の使用感評価
ａ）試験方法
男女１０名を対象に試験を実施した。本発明品であるコウジ酸を含有する制汗スプレー（処方例１）を右腋下に、そして、対照品としてコウジ酸無配合の制汗スプレー（処方例１からコウジ酸を除いたもの）を左腋下に塗布し、軽い運動をしてもらい、軽い運動直後（発汗時）と、運動終了から１０分の休憩後（発汗乾燥後）に、各人以下の基準に従って、使用感（べたつき）の評価を行ってもらった。
１：べたつきを感じる
２：多少べたつきを感じる
３：殆どべたつきを感じない
４：べたつきを感じない
ｂ）試験結果
表２に使用感評価結果を示す。
ｃ）考察
コウジ酸無配合の対照品を使用した左腋下では、１０名中１０名がべたつきを感じる若しくは多少べたつきを感じるという結果であったのに対し、本発明品を使用した右腋では、１０人中１０名がほとんどべたつきを感じない若しくはべたつきを感じないという結果であった。この結果からより明らかなように、本発明制汗剤は発汗時及び発汗乾燥後のべたつきがない優れた使用感を有することが立証された。
なお、試験期間を通じて副作用は全く認められず、安全性が高いことも認められた。
【００１６】
【表２】
【処方例】
以下に本発明の制汗剤の処方例を示す。処方例中、「適量」とは、全体で１００重量％になる割合を意味する。
【００１８】
＜処方例１＞スプレー
＜処方例２＞クリーム
＜処方例３＞乳液
＜処方例４＞ローション（ロールオンタイプ）
＜処方例５＞ローション（スプレータイプ）
＜処方例６＞軟膏剤
＜処方例７＞エッセンス
＜処方例８＞スティック
＜処方例９＞パウダースプレー
上記の処方１ないし９は、いずれも表１および２に示したものと同様の効果を発揮しており、いずれも、本発明の目的において満足する効果を有する製剤であることが確認された。
【００２８】
【発明の効果】
本発明によれば、コウジ酸および／またはその誘導体を含有した塗布剤型または噴霧剤型制汗剤が提供され、この制汗剤は、皮膚に塗布または噴霧することによって優れた制汗作用を有し、さらに、発汗時のべたつきおよび発汗乾燥後のべたつきがなく使用感に優れる。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to an antiperspirant, and more particularly, it has an excellent antiperspirant effect by applying or spraying to the skin with kojic acid and / or its derivatives as an active ingredient. The present invention relates to an antiperspirant excellent in feeling of stickiness after use and without stickiness after sweat drying.
[0002]
[Prior art]
Kojic acid and its derivatives, which the applicant has been studying for many years, are known as highly useful drugs with various excellent characteristics such as fair skin effect and anti-inflammatory effect, and without side effects. Are disclosed, for example, in Japanese Patent Publication No. 57-46825, Japanese Patent Publication No. 61-10447, Japanese Patent Publication No. 58-34446, Japanese Patent Publication No. 60-27648, Japanese Patent Publication No. 55-157509, Japanese Patent Publication No. 6-16685. No. 6, JP-B 63-27322, JP-B 6-13448, JP-A 61-143314, JP-B 5-30422, JP-A 1-1332502, Japanese Patent No. 2549148, Patents No. 2712126, Japanese Patent No. 2504805, Japanese Patent Laid-Open No. 3-86821, Japanese Patent Laid-Open No. 10-17468, Japanese Patent Laid-Open No. 10-59847 Which is incorporated herein by reference.
[0003]
By the way, it is known that organic substances on the skin caused by sebum, sweat, keratin metabolism, etc. are metabolized and decomposed by bacteria to generate odorous substances and cause body odors such as odor. In order to prevent these body odors, (1) suppression of sweating, (2) suppression of skin resident bacteria by sterilization, (3) deodorization of generated odor, and (4) masking of generated odor by fragrance, etc. A method is being tried.
[0004]
Conventionally, various types of antiperspirants such as powder spray, roll-on, stick, gel, cream, etc. have been used, and these are usually antiperspirant, bactericidal and deodorant ingredients and powder, oil ingredients It consists of a surfactant and wax. It has been pointed out that these antiperspirants cause stickiness during use, during sweating and after sweat drying, and in order to solve this problem, powders having sweat-absorbing and sebum-absorbing oil effects such as silicic anhydride. Body, spherical particle powder, silicone-treated powder, and silicone that has a lighter feeling than other oil components, or ingredients that have volatility centered on ethanol etc. Attempts have been made to improve various feelings of use.
[0005]
[Problems to be solved by the present invention]
However, with these methods, stickiness immediately after use can be suppressed to some extent, but sufficient effects cannot be obtained for stickiness during sweating and stickiness after drying after sweating. Moreover, although spherical particle powder is effective in improving the feeling of use, there is also a problem that whitening occurs when mixed in a large amount. For this reason, there has been a demand for the development of an antiperspirant with excellent usability that is not sticky during sweating and after drying after sweating.
[0006]
[Means for Solving the Problems]
The present invention was developed in response to the above-mentioned demands, and in addition to excellent antiperspirant action, earnest research was repeated in search of a material having an effect of preventing stickiness during sweating and stickiness after sweat drying. As a result, kojic acid and / or a derivative thereof have been obtained based on such knowledge by obtaining new knowledge that can effectively achieve the above-mentioned object by applying or spraying to the skin.
That is, according to the present invention, an application comprising kojic acid and / or a derivative thereof as an active ingredient, having an excellent antiperspirant action, and having excellent stickiness during sweating and no stickiness after sweat drying. A dosage form or spray-type antiperspirant is provided.
[0007]
DETAILED DESCRIPTION OF THE INVENTION
The kojic acid (5-oxy-2-oxymethyl-γ-pyrone) used in the present invention is a pure 5-oxy-2-oxymethyl-γ-pyrone, a known strain having kojic acid-producing ability. The fermentation liquid obtained by cultivating kojic acid, the concentrated liquid of the fermentation liquid, and the one obtained by extracting and crystallizing kojic acid from the fermentation liquid are used.
[0008]
Kojic acid derivatives are disclosed in, for example, JP-B-60-10005, JP-B-1-45472, JP-B-3-74229, JP-B58-22151, and JP-B58-22152. Known compounds such as kojic acid derivatives in which kojic acid molecules are stabilized by binding sugars to the esterified product of kojic acid and the -CH 2 OH group at the 2-position of kojic acid, alone or in combination of two or more Can be used.
[0009]
In the present invention, the antiperspirant containing kojic acid and / or a derivative thereof as an active ingredient is used by directly spraying or applying to the affected area in a form for external use acceptable as a cosmetic or quasi-drug.
In this case, the amount of kojic acid and / or its derivative is 0.001 to 10% by weight, preferably 0.1 to 5% by weight, based on the whole preparation.
[0010]
Dosage form of the antiperspirant of the present invention, a cream, a milk, a lotion, essence, gels, pastes, ointments, liniments type or aerosols, such as stick agents and tinctures, sprays type form such as sprays It is intended for wide use.
[0011]
Furthermore, when preparing the antiperspirant of the present invention, various known active ingredients that are commonly used, such as chlorohydroxyaluminum, zinc oxide, allantoinchlorohydroxyaluminum, allantoindihydroxyaluminum, aluminum potassium sulfate, aluminum chloride, P -Zinc phenol sulfonate, aluminum sulfate, aluminum citrate, aluminum acetate, aluminum phenol sulfonate, aluminum anti-naphthol disulfonate, lead acetate, sodium perborate, trichlorohydroxydiphenyl ether (triclosan), benzil chloride Bactericidal ingredients such as ruconium, benzethonium chloride, chlorhexidine hydrochloride, chlorhexidine gluconate, halocarban, zinc oxide, magnesium oxide, zeolite, To the extent that the object of the present invention is not impaired, various deodorant ingredients such as aluminum silicate, anhydrous silicic acid, etc. and various extracts derived from animals, plants, microorganisms such as cinnamon, clove, fennel, ginger, mint, etc. It can be used by appropriately adding depending on the purpose of the occasion. In addition to these known active ingredients, the antiperspirant of the present invention includes powders such as talc and silicic acid, silicone oils such as dimethylpolysiloxane and methylphenylpolysiloxane, octamethylcyclotetrasiloxane, and decamethylcyclohexane. In addition to base components such as cyclic silicones such as pentasiloxane, various additives such as known moisturizers, preservatives, antioxidants, chelating agents, pH adjusters, fragrances, and coloring agents are used as necessary. They can be used in combination as long as the purpose is not impaired.
[0012]
【Example】
Next, the present invention will be described by disclosing experiments and formulation examples, but these disclosures show preferred embodiments of the present invention and do not limit the present invention in any way.
[0013]
<Test Example 1> Antiperspirant Effect a) Test Method A test was conducted on 10 men and women. Apply the essence containing Kojic acid (Prescription Example 7), which is the product of the present invention, to the lower right arm, and apply the essence without Kojic Acid (Prescription Example 7 excluding kojic acid) as the control product to the lower left arm Then, they had a light exercise and immediately after that, they were evaluated on the degree of sweating according to the following criteria.
1: sweating 2: slightly sweating 3: sweating 4: not sweating b) Test results Table 1 shows the antiperspirant effect results.
c) Consideration In the left armpit using the control product containing no kojic acid, 10 out of 10 people sweated, whereas in the starboard arm using the product of the present invention, 10 out of 10 people Five people did not sweat at all, and the remaining five people were also suppressed to sweating to the extent that they sweated. As is clear from this result, it was demonstrated that the antiperspirant of the present invention has an antiperspirant effect.
In addition, no side effects were observed throughout the test period, and it was also confirmed that the safety was high.
[0014]
[Table 1]
<Test Example 2> Usability evaluation during sweating and after sweat drying a) Test method A test was conducted on 10 men and women. An antiperspirant spray containing kojic acid (Prescription Example 1), which is the product of the present invention, is placed under the right armpit, and an antiperspirant spray containing no kojic acid as a control product (excluding kojic acid from Prescription Example 1). Apply to the left armpit and have a light exercise. Immediately after light exercise (when sweating) and after a 10-minute break after exercise (after sweat drying), the feeling of use (stickiness) according to the criteria below each person We had you evaluate.
1: Feeling sticky 2: Feeling sticky to some extent 3: Feeling almost sticky 4: Not feeling sticky b) Test results Table 2 shows the evaluation results of feeling of use.
c) Consideration In the lower left arm using the control product containing no kojic acid, 10 out of 10 people felt sticky or somewhat sticky, whereas in the starboard using the product of the present invention, The result was that 10 out of 10 people did not feel stickiness or stickiness. As is clear from this result, it was demonstrated that the antiperspirant of the present invention has an excellent feeling of use with no stickiness during sweating and after sweat drying.
In addition, no side effects were observed throughout the test period, and it was also confirmed that the safety was high.
[0016]
[Table 2]
[Prescription example]
The prescription example of the antiperspirant of this invention is shown below. In the formulation examples, “appropriate amount” means a ratio of 100% by weight as a whole.
[0018]
<Prescription Example 1> Spray
<Prescription Example 2> Cream
<Prescription Example 3> Emulsion
<Formulation example 4> Lotion (roll-on type)
<Formulation example 5> Lotion (spray type)
<Prescription Example 6> Ointment
<Prescription Example 7> Essence
<Prescription Example 8> Stick
<Formulation example 9> Powder spray
Each of the above formulations 1 to 9 exhibited the same effects as those shown in Tables 1 and 2, and it was confirmed that all of them were preparations having an effect that was satisfactory for the purpose of the present invention.
[0028]
【The invention's effect】
According to the present invention, there is provided an application-type or spray-type antiperspirant containing kojic acid and / or a derivative thereof, and this antiperspirant exhibits an excellent antiperspirant effect when applied or sprayed onto the skin. Furthermore, there is no stickiness when sweating and no stickiness after sweat drying, and the feeling of use is excellent.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18060898A JP4329914B2 (en) | 1998-06-26 | 1998-06-26 | Antiperspirant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18060898A JP4329914B2 (en) | 1998-06-26 | 1998-06-26 | Antiperspirant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000016928A JP2000016928A (en) | 2000-01-18 |
| JP4329914B2 true JP4329914B2 (en) | 2009-09-09 |
Family
ID=16086229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP18060898A Expired - Lifetime JP4329914B2 (en) | 1998-06-26 | 1998-06-26 | Antiperspirant |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4329914B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10002643A1 (en) | 2000-01-21 | 2001-07-26 | Cognis Deutschland Gmbh | New deodorant preparations which have improved storage stability and may have improved skin feel, include a dialkyl carbonate to improve emulsification of the components |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3407935B2 (en) * | 1993-06-30 | 2003-05-19 | 三省製薬株式会社 | External preparation for skin |
| JP3563089B2 (en) * | 1993-07-14 | 2004-09-08 | 三省製薬株式会社 | External preparation for skin |
| JPH092941A (en) * | 1995-06-19 | 1997-01-07 | Tsumura & Co | Bath agent composition and method of using the same |
-
1998
- 1998-06-26 JP JP18060898A patent/JP4329914B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000016928A (en) | 2000-01-18 |
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