[go: up one dir, main page]

JP4336074B2 - Hard sugar-coated tablets with good color and texture - Google Patents

Hard sugar-coated tablets with good color and texture Download PDF

Info

Publication number
JP4336074B2
JP4336074B2 JP2001388506A JP2001388506A JP4336074B2 JP 4336074 B2 JP4336074 B2 JP 4336074B2 JP 2001388506 A JP2001388506 A JP 2001388506A JP 2001388506 A JP2001388506 A JP 2001388506A JP 4336074 B2 JP4336074 B2 JP 4336074B2
Authority
JP
Japan
Prior art keywords
sugar
maltitol
tablet
core
texture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2001388506A
Other languages
Japanese (ja)
Other versions
JP2003155226A (en
Inventor
めぐみ 里見
晋也 小田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Shoji Foodtech Co Ltd
Original Assignee
Mitsubishi Shoji Foodtech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Shoji Foodtech Co Ltd filed Critical Mitsubishi Shoji Foodtech Co Ltd
Priority to JP2001388506A priority Critical patent/JP4336074B2/en
Publication of JP2003155226A publication Critical patent/JP2003155226A/en
Application granted granted Critical
Publication of JP4336074B2 publication Critical patent/JP4336074B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • General Preparation And Processing Of Foods (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)

Description

【0001】
【産業上の利用分野】
【0002】
本発明は、食品および医薬品として用いられる色調および食感が良好な硬質糖衣錠剤に関するものである。
【0003】
【従来の技術および発明が解決しようとする課題】
【0004】
糖衣とは、食品および医薬品を含有する芯剤の表面に糖質層の被膜を施すことであり、これにより芯剤の吸湿や酸化、光分解などの品質低下を軽減し、芯剤の苦味、臭い、刺激などを緩和する役目を果たしている。
【0005】
また、糖衣には「硬質糖衣」と「ソフト(軟質)糖衣」の2種類があり、前者は糖衣層の構成原料が結晶質であり、その原料中に含まれている水が蒸発し、糖衣層を形成する点で後者と区別されている。
【0006】
糖衣に用いられる糖質としては、例えば、特開昭49−108225号公報に紹介されているように、従来は砂糖を用いるのが主流であったが、糖尿病などのように糖の摂取が制限されている場合や虫歯予防の観点から、砂糖以外の糖質を用いた糖衣法が望まれていた。
【0007】
特公平7−55898号公報は、糖衣に用いられる糖質としてマルチトールを採用しているが、糖衣層の破損、ひび割れを軽減するために、マルチトール以外にプルランやガム類などの糖衣補強剤を併用する必要がある。また、糖衣層の色むらが少ない即ち良好な色調であること、糖衣層を噛んだときに砕けやすい食感であること、芯剤表面の糖衣層がパリパリとした食感であること、などの効果に関しては未だ十分なものではなく、特に、冷涼感が感じられ、且つ噛んだときに砕け易い糖アルコールを用いた芯剤に対して、マルチトール糖衣を施す場合の困難さは解決されていない。
【0008】
一般的に、芯剤にマルチトール糖衣を施す場合、マルチトールの結晶性の悪さから、出来上がった糖衣品は砂糖を用いたものに較べて、色むら即ち色調不良の糖衣層となること、糖衣層表面に凹凸が発生すること、芯剤が吸湿する場合があること、不良品の生成率が高いこと、保存性が劣ること、などの問題が生じる場合があった。
【0009】
色むらの少ない糖衣層の形成手段として、特公昭50−6533号公報にはケイ酸アルミン酸マグネシウムを糖衣液に懸濁させる方法が開示されている。しかし、ケイ酸アルミン酸マグネシウムは食品に使用できないだけでなく、糖衣液中に均一に分散しにくいため色むら防止効果が不十分な場合があった。
【0010】
特開2001−57848号公報には、キャンデーを芯剤とし、キャンデーと同じ糖質を糖衣層に使用する吸湿防止方法が開示されている。しかし、この方法は冷涼感を得るために必要な結晶性粉末の芯剤を用いるものではなく、ハードボイルドキャンデーを芯剤として用いるもので、且つキャンデー表面を一度溶かし、温風乾燥させる手法であるため、糖衣層の表面が凹凸になり易く、また糖衣層が薄すぎるため、糖衣が施されていない部分から吸湿が起きるという問題点が生じていた。
【0011】
以上のように、噛んだ時に爽快な冷涼感が得られるような特定の糖アルコールを原料とした芯剤に対して、マルチトールで糖衣を施そうとした場合、表面の色むらがなく、糖衣層のパリパリした食感と芯剤の冷涼感とが得られ、且つ噛み易い程度に硬度が低い硬質糖衣錠剤としては、十分な品質のものが得られていなかったのである。
【0012】
本発明の目的は、キシリトール、エリスリトール、マンニトール、ソルビトールなどの糖アルコールにより冷涼感が得られ、且つ適度な硬度を有した噛み砕き易い芯剤に対して、マルチトールの硬質糖衣を施した、色調および食感が良好な錠剤、つまり、表面の色むらや凹凸が少なく、吸湿性が少なく、尚且つ、表面がパリパリとした食感で、芯剤部分について爽快な冷涼感が感じられ、更に噛み易い錠剤を提供することにある。
【0013】
【課題を解決するための手段】
本発明者等は、上記課題を解決するため鋭意研究した結果、芯剤に糖質として結晶性マルチトールを10.0〜50.0重量%(以下、断りが無い限り%は重量%を表す)含有させ、且つ冷涼感を得られる糖アルコールとマルチトールの混合物を芯剤中に50.0%以上含有せしめ、これに着色料を含有したマルチトール液を用いて結晶質の糖衣層を形成させることにより、色調および食感が良好な、つまり、色むら、凹凸、吸湿性が少なく、尚且つ糖衣層がパリパリとした食感を持ちながら芯剤部分で冷涼感が感じられて噛み砕き易い錠剤を調製することに成功し、本発明を完成するに至った。
【0014】
即ち、第1の本発明は、成分(a)結晶性マルチトール10.0〜50.0%、および成分(b)キシリトール、エリスリトール、マンニトール、ソルビトールからなる群から選ばれる1種もしくは2種以上の混合物である結晶性粉末50.0〜90.0%、の混合物を50.0%以上含有する芯剤に、着色料を含有したマルチトール液で糖衣を施すことにより得られる、色調および食感が良好な硬質糖衣錠剤である。
【0015】
また、第2の本発明は、試験法Aによる芯剤の硬度が1.5〜20.0kgである前記第1の発明に記載の色調および食感が良好な硬質糖衣錠剤である。
【0016】
本発明における硬度とは、芯剤部分に力を加えて錠剤を崩壊させた場合の力をkgで表したもので、測定方法は試験法Aを採用する。試験法Aとは、富山産業株式会社製TH−203CP錠剤崩壊度試験機を用いて錠剤の横方向(一般的な円盤型の錠剤の場合は剤の帯の部分)に力を加え、割れた時の力を硬度とする方法である
【0017】
本発明でいう色調とは、着色料を含有したマルチトール液を用いて糖衣した後の錠剤表面を目視した場合の色調を意味し、均一に着色されているもの、即ち色むらの無いものを良好な色調と言う。
【0018】
また、本発明でいう食感とは、糖衣層を噛んだ際に心地よくパリパリと噛み砕くことができること、芯剤部分を噛んだ時に容易に砕けること、並びに咀嚼中に芯剤成分が爽快な冷涼感を与えることの、何れか又は全てを言う。
【0019】
本発明において用いる芯剤とは、例えば、粉末を打錠した品を意味し、芯剤の形状は、球形や角が丸く上下が凸球面の円盤状や円柱状の場合に、容易に糖衣できるので理想的であるが、枕型やサイコロ型など、従来の糖衣方法では均一で良好な糖衣が得られにくい形状であっても本発明の場合には有利に採用することができる。
【0020】
また、芯剤には、上記した成分(a)および成分(b)の混合物が50.0%以上含まれていればよく、残余は健康増進のための食品成分や薬効成分、呈味成分など、通常の錠剤や錠菓に用いられる成分、例えば、ビタミン類、各種ミネラル、高甘味度甘味料、酸味料、香料、各種塩類、食物繊維、各種果汁、などのほか、滑沢剤などが任意に使用できる。
【0021】
芯剤中の成分(a)および成分(b)が50.0%未満の場合、着色料を含有したマルチトール液が糖衣層を形成する際、結晶の生成速度が不足するなどの原因により、均一な糖衣層の形成が困難になるため、結果として糖衣層に色むらが生じ易くなる、パリパリとした良好な食感の糖衣層となりにくい、芯剤部分を咀嚼しても爽快な冷涼感を感じることができない、などの影響が現れるため好ましくない。
【0022】
本発明の糖衣錠剤には成分(a)として結晶性マルチトールが用いられるが、これは芯剤をマルチトール液で糖衣する際に結晶質の糖衣層を得るための種結晶の役割を果たすものである。よって、マルチトール結晶やマルチトール含蜜結晶の他にも、例えばマルチトール結晶を含んだ粉末状または水分の少ないスラリー状であっても使用可能である。
【0023】
結晶性マルチトールの品質については、食品や医薬品として採用可能な程度であればよいが、糖衣層の結晶形成を容易にすることからマルチトールの純度が90.0%以上のものが好ましい。また、そのような品質の結晶性マルチトール中でもマルトトリイトールとマルトテトライトールの含量の和が3.0%以下のものは糖衣層の結晶形成速度を速くするので、本発明を実施した際に種々の効果が得られ、更に有利に採用できる。
【0024】
また、本発明においては成分(a)と成分(b)との合計を100%とした場合に、結晶性マルチトールが10.0〜50.0%であることも要求され、その更に好ましい実施態様は結晶性マルチトールが20.0〜40.0%であるが、結晶性マルチトールが10.0%未満の場合は、糖衣層における結晶化が不充分になる場合が多く、また、50.0%を超えた場合は、芯剤中の冷涼感が損なわれるなどの影響が出る。
【0025】
成分(b)の量についても、成分(a)との合計を100%とした場合に成分(b)が50.0〜90.0%であることが要求され、成分(b)が50.0%未満の場合には芯剤中の冷涼感が損なわれるなどの影響があり、90.0%を超えた場合には糖衣層における結晶化が不充分になる場合が多くなる。
【0026】
本発明の成分(b)として用いられるキシリトール、エリスリトール、マンニトール、ソルビトールは、口中で溶解する際に熱を奪って冷涼感を与えるため、結晶を含有する粉末状であることが要求されるが、食品、食品添加物、局方品として用いられる程度の品質を備えていることが好ましい。なお、製法や由来、純度や粒径等に格別の制約はなく、また、これらキシリトール、エリスリトール、マンニトール、ソルビトールは、単独で用いることも、複数を組み合わせて用いることも自由である。
【0027】
本発明に用いる成分(b)として採用できる、キシリトール、エリスリトール、マンニトール、ソルビトールについて、これらの40℃における溶解時の吸熱量をkcal/kgで表すと、それぞれ−36.6、−42.9、−28.9、−26.5であり、この吸熱量の大きさにより、噛んだときに心地よい冷涼感を得ることができる。
【0028】
芯剤の硬度は、成分(a)と成分(b)とを本発明限定範囲のように含有することにより、適度に噛み砕きやすい硬度のものが得られるが、更に好ましくはその範囲内で、試験法Aによる硬度が1.5kg〜20.0kgとなるように調製することにより、一層良好な食感が得られる。この硬度が1.5kg未満の場合には、糖衣層を形成する工程や、その後の充填、包装、運搬等の際に剤が割れたり、傷がつくことがあり、また、硬度が20.0kgを超えた場合は、糖衣層がパリパリとした良好な食感であっても更に芯剤部分を噛んだときに硬さが感じられ、噛み心地のバランスに欠けたものとなる。
【0029】
芯剤の製造方法について特別な制約はないが、本発明の特徴のひとつである冷涼感を損なわないために、芯剤中に結晶が残る方法であることが要求され、それには、直接打錠や、湿式造粒または乾式造粒後の打錠による方法などがある。また、芯剤を調製する際に、プルランやカルボキシメチルセルロース、HPMC(ヒドロキシプロピルメチルセルロース)、還元水飴、還元デストリン等をバインダーとして任意に使用することもできる。
【0030】
次に、本発明に係る糖衣層の形成に用いられるマルチトール液は、食品用途や医薬品用途に用いられる品質を備え、且つ、糖衣層形成時に適度な結晶性を備えているものが要求されるが、それには市販の純度90.0%以上のマルチトール製品が有利に採用可能である。更に、糖衣層の結晶形成速度を早くし、本発明を実施した際に種々の効果が得られることから、マルチトール製品中のマルトトリイトールとマルトテトライトールの含量の和は3.0%以下であることが好ましい。糖衣に用いる際のマルチトール液の固形分濃度は、通常50.0〜80.0%程度が有利に採用できる。
【0031】
また、マルチトール液は着色料を含有していることが要求されるが、用いる着色料には格別の制約がなく、例えばタール系色素、ビタミンB2、二酸化チタン、カロテノイド系色素、キノン系色素、フラボノイド系色素、カルコン系色素、フラボン系色素、フラボノール系色素、スピルリナ青色素、クロロフィル、銅クロロフィル、銅クロロフィリンナトリウム、赤ビート色素、紅こうじ色素、紅こうじ黄色素、ウコン色素、クチナシ青色素、カラメル色素、クルクミン、酸化鉄、パプリカオレンジ、ターメリック、などの着色料の他にも、本発明においては、砂糖を用いた糖衣の際には糖の分解などの理由から不可能とされるアントシアニン系の色素をも酸性下での調製により有利に採用することができる。
【0032】
糖衣層の形成に用いるマルチトール液には、着色料の他に、香料、保存料、崩壊剤、被膜剤、艶出し剤、高甘味度甘味剤、アラビアガムなどの結合剤、澱粉、増粘剤、タルクやカオリンや各種カルシウム塩などの懸濁基剤、糖アルコールなどを、結晶質の糖衣層を形成する性質を失わない範囲で任意に添加することができる。
【0033】
本発明の糖衣は硬質糖衣、即ち糖衣層が結晶質であり、その形成方法は芯剤をマルチトール液で噴霧などの手段により被覆し、必要に応じて粉掛けした後送風乾燥して水分を蒸発させ、マルチトール結晶の析出を促す操作を数回から数十回、あるいは所望の厚さの糖衣層を形成するまで繰り返し行う。糖衣層の厚さは任意に選択できるが、芯剤の重量を100としたときに、糖衣層の重量が30〜80程度の場合に良好な食感が得られる場合が多い。
【0034】
本発明の実施により得られた硬質糖衣層は、その表面処理として艶出し操作を初めとする2次加工を任意に行うことも可能である。
【0035】
以上のように、本発明を実施することにより、色調および食感が良好な、つまり、表面の色むらがなく、噛んだときにパリパリとした食感が得られ、更に噛んだときに適度に砕け易く、冷涼感が感じられる錠剤を得ることができる。
【0036】
以下に、実施例に基づいて本発明の内容を更に具体的に説明するが、本発明の技術的範囲は以下の例に制限されるものではない。
【0037】
芯剤となる錠剤の作成は、回転式打錠機(菊水製作所製、8F−3型)を使用し、糖衣層の作成には、小型糖衣機(菊水製作所製、16DS型)を使用した。
【0038】
【実施例1】
【0039】
キシリトール[東和化成工業株式会社製、商品名:キシリット]を40メッシュパス80メッシュオンに粒度調整したものと、結晶性マルチトール[東和化成工業株式会社製、商品名:アマルティMR50(登録商標)、マルチトール純度=93.9%、マルトトリイトールとマルトテトライトールの含有量の和=2.7%]を粒度調整せずに用い、さらにショ糖脂肪酸エステル(第一工業製薬株式会社製、商品名:DKS F−20W)と、l−メントール、を表1に記載した配合比で混合した後、上杵目盛り位置1mm、下杵目盛り位置5mmとし、10φ×8.5Rの杵を装着した回転式打錠機で直接打錠して、直径10mm、厚さ4.7mm、平均重量320mg/錠の芯剤を得た。
【0040】
次に、得られた芯剤1000錠を小型糖衣機に入れ、マルチトール[東和化成工業株式会社製、商品名:レシス(登録商標)、マルチトール純度=99.0%、マルトトリイトールとマルトテトライトールの含有量の和=0.5%]を用いて表1に記載した配合比でマルチトール液を調製し、温度20〜40℃で一度に約4g程度の液掛けと送風乾燥を繰り返す常法により糖衣操作を行い、平均重量480mg/錠の糖衣錠剤A1を得た。
【0041】
【実施例2】
【0042】
キシリトールに代えてエリスリトール[三菱化学フーズ株式会社製]を粒度調整せずに用いた以外は、実施例1と同一の成分を表1に記載した配合比で混合し、回転式打錠機で直接打錠して、平均重量320mg/錠の芯剤を得た。
次に、表1に記載した配合比でマルチトール液を調製した以外は、実施例1と同様の方法で糖衣操作を行い、平均重量448mg/錠の糖衣錠剤A2を得た。
【0043】
【実施例3】
【0044】
キシリトールに代えてマンニトール[東和化成工業株式会社製、商品名:マンニットP]を粒度調整せずに用いた以外は、実施例1と同一の成分を表1に記載した配合比で混合し、回転式打錠機で直接打錠して、平均重量320mg/錠の芯剤を得た。
次に、表1に記載した配合比でマルチトール液を調製した以外は、実施例1と同様の方法で糖衣操作を行い、平均重量576mg/錠の糖衣錠剤A3を得た。
【0045】
【実施例4】
【0046】
キシリトールに代えてソルビトール[東和化成工業株式会社製、商品名:ソルビットDP−50]を粒度調整せずに用いた他は、実施例1と同一の成分を表1に記載した配合比で混合し、回転式打錠機で直接打錠して、平均重量320mg/錠の芯剤を得た。
次に、表1に記載した配合比でマルチトール液を調製した以外は、実施例1と同様の方法で糖衣操作を行い、平均重量512mg/錠の糖衣錠剤A4を得た。
【0047】
【実施例5】
【0048】
キシリトール[東和化成工業株式会社製、商品名:キシリット(微粉)]、マンニトール[商品名:マンニットP]、結晶性マルチトール[東和化成工業株式会社製、商品名:レシス(微粉)、マルチトール純度=99.0%、マルトトリイトールとマルトテトライトールの含有量の和=0.5%]をそれぞれ粒度調整せずに用い、更に1−メントール、ビタミンC、HPMCを、表2に記載した配合比で混合し、これに全重量の10%の純水を噴霧した後、押出し造粒機(菊水製作所製 RG−8M−2U)にて押出し、50℃で8時間乾燥した。次いで、ステアリン酸マグネシウム(試薬、関東化学株式会社製)を、表2に記載した配合比で添加、混合し、回転式打錠機で直接打錠して、平均重量320mg/錠の芯剤を得た。
【0049】
次に、得られた芯剤1000錠を小型糖衣機に入れ、マルチトール[商品名:レシス]を用いて、表2に記載した配合比でマルチトール液を調製し、得られた芯剤に対して実施例1と同様の方法で糖衣操作を行い、平均重量512mg/錠の糖衣錠剤A5を得た。
【0050】
【実施例6】
【0051】
キシリトールとマンニトールに代えて、エリスリトールの微粉品[三菱化学フーズ株式会社製]とソルビトール[商品名:ソルビットDP−50]をそれぞれ粒度調整せずに用いた以外は、実施例5と同一の成分を表2に記載した配合比で混合した後、実施例5と同様の方法により、平均重量320mg/錠の芯剤を得た。
次に、表2に記載した配合比でマルチトール液を調製した以外は、実施例5と同様の方法で糖衣操作を行い、平均重量448mg/錠の糖衣錠剤A6を得た。
【0052】
【実施例7】
【0053】
キシリトールに代えてエリスリトールの微粉品[三菱化学フーズ株式会社製]とパラチニット[三井製糖株式会社製、商品名:パラチニットPNP(登録商標)]をそれぞれ粒度調整せずに用いた以外は、実施例5と同一の成分を表2に記載した配合比で混合した後、実施例5と同様の方法により、平均重量320mg/錠の芯剤を得た。
次に、表2に記載した配合比でマルチトール液を調製した以外は、実施例5と同様の方法で糖衣操作を行い、平均重量544mg/錠の糖衣錠剤A7を得た。
【0054】
【比較例1】
【0055】
結晶性マルチトールを芯剤原料に用いなかった以外は、実施例1と同一の成分を表3に記載した配合比で混合した後、実施例1と同様の方法により、平均重量320mg/錠の芯剤を得た。
次に、結晶性マルチトール[商品名:レシス]を用いて、表3に記載した配合比でマルチトール液を調製し、実施例1と同様の方法で糖衣操作を行い糖衣錠剤を得ようとしたが、錠剤硬度が低すぎて糖衣作業中に錠剤が割れてしまい、糖衣錠剤を得ることが出来なかった。以下、この比較例1で得た錠剤を、便宜的にB1と称す。
【0056】
【比較例2】
【0057】
表3に記載した配合比で芯剤原料を混合した後、実施例1と同様の方法により、結晶性マルチトール含量4.7%、平均重量320mg/錠の芯剤を得た。
次に、表3に記載した配合比でマルチトール液を調製した以外は、実施例1と同様の方法で糖衣操作を行い、平均重量512mg/錠の糖衣錠剤B2を得た。
【0058】
【比較例3】
【0059】
表3に記載した配合比で芯剤原料を混合した後、実施例1と同様の方法により、結晶性マルチトール含量56.1%、平均重量320mg/錠の芯剤を得た。
次に、表3に記載した配合比でマルチトール液を調製した以外は、実施例1と同様の方法で糖衣操作を行い、平均重量512mg/錠の糖衣錠剤B3を得た。
【0060】
【比較例4】
【0061】
表3に記載した配合比で芯剤原料を混合した後、実施例1と同様の方法により、成分(a)と成分(b)の合計含量44.0%、平均重量320mg/錠の芯剤を得た。
次に、表3に記載した配合比でマルチトール液を調製し、実施例1と同様の方法で糖衣操作を行い糖衣錠剤を得ようとしたが、錠剤硬度が低すぎて糖衣作業中に錠剤が割れてしまい、糖衣錠剤を得ることが出来なかった。以下、この比較例4で得た錠剤を、便宜的にB4と称す。
【0062】
【比較例5】
【0063】
表4に記載した配合比で芯剤原料を混合した以外は、実施例1と同様の方法により、平均重量320mg/錠の芯剤を得た。
次に、表3に記載した成分および配合比で、マルチトールを含有しないコーティング液を調製した以外は、実施例1と同様の方法で糖衣操作を行い、平均重量326mg/錠のコーティング錠剤B5を得た。
【0064】
【比較試験1】
【0065】
[食感(錠剤硬度)]
各実施例及び比較例で得られた芯部の錠剤硬度を試験法Aで測定した。1種類の試料につき10回の測定を繰り返し、その平均値を表5〜7に示した。
【0066】
芯部の錠剤は硬すぎても、脆くても好まれないが、本発明の実施品A1〜A7及び比較例のB3及びB5の錠剤硬度は2.2〜18.5kgの好ましい硬度で、噛んだ時、噛み砕けるのに対し、比較例のB1とB4は非常に脆く、好ましい歯ごたえではなかった。またB2は硬すぎて容易に噛み砕けず、好ましい食感ではなかった。
【0067】
【比較試験2】
【0068】
[色調(色むら)評価]
色むらについては、訓練されたパネリスト10名が本発明の実施品A1〜A7及び比較例のB2、B3、B5について、糖衣錠剤表面の色の均一性を目視で評価することにより行った。
【0069】
色調評価は、3点:「色むらが全く無し」、2点:「色むらがほとんど無し」、1点:「色むらが少しあり」、0点「色むらがかなりあり」として集計し、結果は30点〜26点を色調「良好」として◎、25点〜16点を「やや良好」として○、15点〜6点を「やや不良」として△、5点未満を「不良」として×で表した。B1とB4は実施した条件では糖衣できず、評価不可能であった。
この色調評価の結果から、本発明を実施した場合、糖衣錠剤表面の色むらが少なく、外観が美しく仕上がることが示された。
【0070】
【比較試験3】
【0071】
[平滑性の評価]
平滑性については、訓練されたパネリスト10名が本発明の実施品A1〜A7及び比較例のB2、B3、B5の糖衣錠剤表面の凹凸を目視で評価することにより行った。
【0072】
平滑性の評価は、3点:「凹凸が全く無し」、2点:「凹凸がほとんど無し」、1点:「若干凹凸あり」、0点:「凹凸が多い」として集計し、結果は30点〜26点を「平滑」として◎、25点〜16点を「やや平滑」として○、15点〜6点を「少し凹凸あり」として△、5点未満を「凹凸あり」として×で表した。
この平滑性の評価の結果から本発明を実施した場合、糖衣錠剤表面の平滑性が高く、また外観が美しく仕上がることが示された。
【0073】
【比較試験4】
【0074】
[吸湿性の評価]
試料1種類につきそれぞれ秤量瓶2個を用意し、各実施例及び比較例で得られた糖衣錠剤を各5個づつ入れ、温度40℃、相対湿度81%で16時間保存し、糖衣錠剤の重量変化を測定した。増加した重量を吸湿分として、元の糖衣錠剤の重量を100として百分率で表し、吸湿性の評価を行った。
この測定結果から本発明を実施した場合、明らかに吸湿性が改善されていることが示された。
【0075】
【比較試験5】
【0076】
[食感(冷涼感)の評価]
冷涼感については、訓練されたパネリスト10名が本発明の実施品A1〜A7及び比較例のB2、B3、B5の糖衣錠剤を噛んだ時に感じる口の中での冷涼感ついて評価することにより行った。
【0077】
冷涼感の評価は、3点:「強い冷涼感がある」、2点:「冷涼感がある」、1点:「冷涼感が弱い」、0点:「冷涼感なし」として集計し、結果は30点〜26点を食感(冷涼感)「良好」として◎、25点〜16点を食感(冷涼感)「やや良好」として○、15点〜6点を食感(冷涼感)「やや不良」として△、5点未満を食感(冷涼感)「不良」として×で表した。
この測定結果から本発明を実施した場合、明らかに口の中での爽快で良好な冷涼感が得られることが示された。
【0078】
【比較試験6】
【0079】
[食感(クランチ性)の評価]
クランチ性については、訓練されたパネリスト10名が本発明の実施品A1〜A7及び比較例のB2、B3、B5の糖衣錠剤を口の中で噛み砕き、その時に感じることが出来るパリパリとした食感、つまりクランチ性について評価することにより行った。
【0080】
クランチ性の評価は、3点:「強いクランチ性がある」、2点:「クランチ性がある」、1点:「クランチ性が弱い」、0点:「クランチ性なし」によって集計し、結果は30点〜26点を食感(クランチ性)「良好」として◎、25点〜16点を食感(クランチ性)「やや良好」として○、15点〜6点を食感(クランチ性)「やや不良」として△、5点未満を食感(クランチ性)「不良」として×で表した。
この測定結果から本発明を実施した場合、明らかに良好なクランチ性が得られることが示された。
【0081】
【表1】

Figure 0004336074
【0082】
【表2】
Figure 0004336074
【0083】
【表3】
Figure 0004336074
【0084】
【表4】
Figure 0004336074
【0085】
【表5】
Figure 0004336074
【0086】
【表6】
Figure 0004336074
【0087】
【表7】
Figure 0004336074
[0001]
[Industrial application fields]
[0002]
The present invention relates to a hard sugar-coated tablet having a good color tone and texture that is used as food and pharmaceutical products.
[0003]
[Background Art and Problems to be Solved by the Invention]
[0004]
Sugar coating is a coating of a sugar layer on the surface of a core containing food and pharmaceuticals, thereby reducing quality deterioration such as moisture absorption, oxidation, and photolysis of the core, and the bitterness of the core. It plays a role in relieving odor and irritation.
[0005]
In addition, there are two types of sugar coatings, “hard sugar coating” and “soft (soft) sugar coating”. In the former, the constituent material of the sugar coating layer is crystalline, and the water contained in the raw material evaporates. It is distinguished from the latter in that it forms a layer.
[0006]
As sugars used in sugar coatings, for example, as previously introduced in JP-A-49-108225, sugar has been the mainstream, but sugar intake is limited as in diabetes. From the viewpoint of preventing dental caries, a sugar coating method using sugars other than sugar has been desired.
[0007]
Japanese Patent Publication No. 7-55898 employs maltitol as a sugar used in sugar coating, but in order to reduce damage and cracking of the sugar coating layer, in addition to maltitol, sugar coating reinforcing agents such as pullulan and gums Need to be used together. In addition, the sugar coating layer has less uneven color, that is, a good color tone, a texture that is easily crushed when the sugar coating layer is chewed, and the sugar coating layer on the core surface has a crispy texture. The effect is not yet sufficient, especially the difficulty in applying maltitol sugar coating to a core agent that uses sugar alcohol that feels cool and is easy to break when chewed. .
[0008]
In general, when maltitol sugar coating is applied to the core agent, due to the poor crystallinity of maltitol, the finished sugar coating product has a color unevenness, that is, a sugar coating layer with poor color tone, compared to those using sugar. Problems such as unevenness on the surface of the layer, the core agent may absorb moisture, the generation rate of defective products is high, and the storage stability is inferior may occur.
[0009]
Japanese Patent Publication No. 50-6533 discloses a method of suspending magnesium aluminate silicate in a sugar coating solution as a means for forming a sugar coating layer with little color unevenness. However, magnesium aluminate silicate cannot only be used in foods, but it is difficult to disperse uniformly in a sugar coating liquid, and thus there are cases where the effect of preventing color unevenness is insufficient.
[0010]
Japanese Patent Application Laid-Open No. 2001-57848 discloses a moisture absorption prevention method using candy as a core and using the same sugar as candy for a sugar coating layer. However, this method does not use a crystalline powder core necessary for obtaining a cool feeling, but uses a hard boiled candy as a core, and is a technique in which the candy surface is once melted and dried with hot air. For this reason, the surface of the sugar-coating layer tends to be uneven, and the sugar-coating layer is too thin, causing a problem that moisture absorption occurs from a portion where the sugar-coating is not applied.
[0011]
As described above, when a sugar coating is applied with maltitol for a core material made of a specific sugar alcohol that gives a refreshing cool feeling when chewed, there is no uneven color on the surface, and the sugar coating As a hard sugar-coated tablet having a crispy texture of the layer and a cool feeling of the core, and having a hardness low enough to be chewed, a tablet of sufficient quality has not been obtained.
[0012]
The object of the present invention is to obtain a cool feeling with sugar alcohols such as xylitol, erythritol, mannitol, sorbitol, etc., and to a chewable core agent having an appropriate hardness, with a color tone and a hard sugar coating of maltitol Tablets with good texture, that is, with less uneven color and unevenness on the surface, less hygroscopicity, and a texture that is crispy on the surface, a refreshing cool feeling is felt about the core part, and it is easier to chew To provide tablets.
[0013]
[Means for Solving the Problems]
As a result of intensive studies to solve the above problems, the present inventors have found that the core material contains 10.0 to 50.0% by weight of crystalline maltitol as a saccharide (hereinafter, unless otherwise indicated,% represents% by weight). ) Add 50.0% or more of a mixture of sugar alcohol and maltitol that can be contained and give a cool feeling to the core, and form a crystalline sugar coating layer using a maltitol solution containing a coloring agent. By making the tablet, the color tone and texture are good, i.e., the color unevenness, unevenness, moisture absorption is small, and the sugar coating layer has a crispy texture, and a cool feeling is felt in the core part and it is easy to chew Has been successfully completed, and the present invention has been completed.
[0014]
That is, 1st this invention is 1 type, or 2 or more types chosen from the group which consists of component (a) crystalline maltitol 10.0-50.0%, and component (b) xylitol, erythritol, mannitol, sorbitol The color tone and food obtained by applying sugar coating with a maltitol solution containing a coloring agent to a core containing 50.0% to 90.0% of a mixture of crystalline powder 50.0-90.0%. It is a hard sugar-coated tablet with a good feeling.
[0015]
Moreover, 2nd this invention is a hard sugar-coated tablet with favorable color tone and food texture as described in said 1st invention whose hardness of the core agent by the test method A is 1.5-20.0 kg.
[0016]
The hardness in the present invention is the force expressed in kg when the tablet is disintegrated by applying a force to the core part, and the test method A is adopted as the measuring method. The test method A, a force in the lateral direction of the tablet (general disk-shaped band portion of the case agent tablets) using Toyama Sangyo Co., Ltd. TH-203C P tablets agent disintegration tester, This is a method in which the force at the time of cracking is set to hardness.
[0017]
The color tone referred to in the present invention means the color tone when the tablet surface after sugar coating using a maltitol solution containing a colorant is visually observed, and is uniformly colored, i.e., no color unevenness. Say good color.
[0018]
In addition, the texture according to the present invention means that it can be comfortably crushed when chewing the sugar-coating layer, it can be easily crushed when the core part is chewed, and the refreshing cool feeling of the core component during chewing To give any or all of
[0019]
The core used in the present invention means, for example, a product obtained by tableting a powder, and the core can be easily sugar-coated when it has a spherical shape or a round or rounded disk shape or cylindrical shape with a convex spherical surface. Therefore, it is ideal, but even a shape such as a pillow type or a dice type in which a conventional sugar coating method is difficult to obtain a uniform and good sugar coating can be advantageously employed in the present invention.
[0020]
Moreover, the core agent should just contain 50.0% or more of the mixture of said component (a) and component (b), and the remainder is a food ingredient, a medicinal ingredient, a taste ingredient, etc. for health promotion. In addition to ingredients used in ordinary tablets and tablet confectionery, for example, vitamins, various minerals, high-intensity sweeteners, acidulants, fragrances, various salts, dietary fiber, various fruit juices, and lubricants are optional. Can be used for
[0021]
When the component (a) and the component (b) in the core agent is less than 50.0%, when the maltitol liquid containing the colorant forms a sugar coating layer, due to a cause such as insufficient crystal generation rate, Since it is difficult to form a uniform sugar-coated layer, color unevenness is likely to occur in the sugar-coated layer. As a result, it is difficult to form a sugar-coated layer with a good crispy texture. It is not preferable because the effect of not being able to feel it appears.
[0022]
In the sugar-coated tablet of the present invention, crystalline maltitol is used as the component (a), and this plays the role of a seed crystal for obtaining a crystalline sugar-coated layer when the core agent is sugar-coated with maltitol liquid. It is. Thus, in addition to maltitol crystals and maltitol-containing crystals, for example, powders containing maltitol crystals or slurries with little moisture can be used.
[0023]
The quality of the crystalline maltitol is not particularly limited as long as it can be used as a food or a pharmaceutical. However, it is preferable that the maltitol has a purity of 90.0% or more in order to facilitate crystal formation of the sugar coating layer. Further, among the crystalline maltitol of such quality, those having a sum of the contents of maltotriitol and maltotetriitol of 3.0% or less increase the rate of crystal formation of the sugar coating layer. Various effects can be obtained, and it can be used more advantageously.
[0024]
Further, in the present invention, when the total of the component (a) and the component (b) is 100%, the crystalline maltitol is also required to be 10.0 to 50.0%, and more preferable implementation thereof. In the embodiment, the crystalline maltitol is 20.0 to 40.0%. However, when the crystalline maltitol is less than 10.0%, crystallization in the sugar-coating layer is often insufficient, and 50 If it exceeds 0.0%, the cooling sensation in the core will be impaired.
[0025]
Also regarding the amount of component (b), component (b) is required to be 50.0-90.0% when the total with component (a) is 100%, and component (b) is 50. If it is less than 0%, the cooling sensation in the core agent is impaired, and if it exceeds 90.0%, crystallization in the sugar coating layer is often insufficient.
[0026]
Xylitol, erythritol, mannitol and sorbitol used as the component (b) of the present invention are required to be in a powder form containing crystals in order to take heat and give a cool feeling when dissolved in the mouth. It is preferable to have a quality that can be used as a food, food additive, or pharmacopoeia. The production method, origin, purity, particle size and the like are not particularly limited, and these xylitol, erythritol, mannitol, and sorbitol can be used alone or in combination.
[0027]
When xylitol, erythritol, mannitol, and sorbitol that can be employed as the component (b) used in the present invention are expressed in terms of kcal / kg as the endothermic amount when dissolved at 40 ° C., respectively, −36.6, −42.9, -28.9 and -26.5. Due to the magnitude of the endothermic amount, a pleasant cool feeling can be obtained when chewing.
[0028]
With regard to the hardness of the core agent, by containing the component (a) and the component (b) as in the limited range of the present invention, those having moderately easy to crush hardness can be obtained. By preparing so that the hardness according to Method A is 1.5 kg to 20.0 kg, a better texture can be obtained. If this hardness is less than 1.5 kg, the agent may be cracked or scratched during the process of forming a sugar coating layer and subsequent filling, packaging, transporting, etc., and the hardness is 20.0 kg. In the case of exceeding the above, even if the sugar-coating layer has a good crispy texture, hardness is felt when the core part is further chewed and the chewing feeling is lacking in balance.
[0029]
There are no particular restrictions on the manufacturing method of the core, but in order not to impair the cool feeling that is one of the features of the present invention, it is required that the crystal remains in the core, and it is directly compressed into tablets. There are also methods such as tableting after wet granulation or dry granulation. In preparing the core agent, pullulan, carboxymethylcellulose, HPMC (hydroxypropylmethylcellulose), reduced starch syrup, reduced destrin and the like can be arbitrarily used as a binder.
[0030]
Next, the maltitol liquid used for the formation of the sugar-coating layer according to the present invention is required to have a quality that is used for food applications and pharmaceutical applications and that has appropriate crystallinity when the sugar-coating layer is formed. However, a commercially available maltitol product having a purity of 90.0% or more can be advantageously used. Furthermore, since the rate of crystal formation of the sugar coating layer is increased and various effects are obtained when the present invention is carried out, the sum of the contents of maltotriitol and maltotetriitol in the maltitol product is 3.0%. The following is preferable. The solid content concentration of the maltitol liquid when used for sugar coating can normally be advantageously employed as about 50.0-80.0%.
[0031]
The maltitol liquid is required to contain a colorant, but the colorant to be used is not particularly limited. For example, tar dye, vitamin B2, titanium dioxide, carotenoid dye, quinone dye, Flavonoid dyes, chalcone dyes, flavone dyes, flavonol dyes, spirulina blue dyes, chlorophyll, copper chlorophyll, copper chlorophyllin sodium, red beet dyes, red koji dye, red koji yellow, turmeric dye, gardenia blue dye, caramel In addition to coloring agents such as pigments, curcumin, iron oxide, paprika orange, turmeric, etc., in the present invention, in the case of sugar coating using sugar, anthocyanin type which is impossible for reasons such as decomposition of sugar Dyes can also be advantageously employed by preparation under acidic conditions.
[0032]
In addition to coloring agents, maltitol liquids used for the formation of sugar coating layers include flavorings, preservatives, disintegrating agents, coating agents, polishes, high-intensity sweeteners, binders such as gum arabic, starch, thickening Agents, suspension bases such as talc, kaolin and various calcium salts, sugar alcohols and the like can be optionally added as long as the property of forming a crystalline sugar coating layer is not lost.
[0033]
The sugar coating of the present invention is a hard sugar coating, i.e., the sugar coating layer is crystalline, and the forming method is to coat the core with a maltitol solution by means of spraying, etc. The operation of evaporating and promoting the precipitation of maltitol crystals is repeated several to several tens of times or until a sugar coating layer having a desired thickness is formed. The thickness of the sugar-coating layer can be selected arbitrarily, but when the weight of the core agent is 100, a good texture is often obtained when the weight of the sugar-coating layer is about 30 to 80.
[0034]
The hard sugar coating layer obtained by carrying out the present invention can optionally be subjected to secondary processing including polishing operation as its surface treatment.
[0035]
As described above, by carrying out the present invention, the color tone and texture are good, that is, there is no uneven color on the surface, a crispy texture is obtained when chewed, and when chewing is moderately moderate Tablets that are easy to break and feel cool can be obtained.
[0036]
Hereinafter, the contents of the present invention will be described more specifically based on examples, but the technical scope of the present invention is not limited to the following examples.
[0037]
A tablet used as a core was prepared by using a rotary tableting machine (manufactured by Kikusui Seisakusho, 8F-3 type), and a sugar coating layer (manufactured by Kikusui Seisakusho, 16DS) was used for producing a sugar coating layer.
[0038]
[Example 1]
[0039]
Xylitol [manufactured by Towa Kasei Kogyo Co., Ltd., trade name: Xylit] having a particle size adjusted to 40 mesh pass 80 mesh on, crystalline maltitol [manufactured by Towa Kasei Kogyo Co., Ltd., trade name: Amarty MR50 (registered trademark), Maltitol purity = 93.9%, sum of contents of maltotriitol and maltotetriitol = 2.7%] without adjusting the particle size, and sucrose fatty acid ester (Daiichi Kogyo Seiyaku Co., Ltd., (Product name: DKS F-20W) and l-menthol were mixed at the blending ratio shown in Table 1, and then the upper heel scale position was 1 mm and the lower heel scale position was 5 mm, and a 10φ × 8.5R ridge was attached. Direct tableting was performed with a rotary tableting machine to obtain a core having a diameter of 10 mm, a thickness of 4.7 mm, and an average weight of 320 mg / tablet.
[0040]
Next, 1000 tablets of the obtained core agent were put into a small sugar coating machine, maltitol [manufactured by Towa Kasei Kogyo Co., Ltd., trade name: Resis (registered trademark), maltitol purity = 99.0%, maltotriitol and malt A maltitol solution is prepared at a blending ratio shown in Table 1 using the sum of the content of tetritols at 0.5%, and about 4 g at a time at a temperature of 20 to 40 ° C. Sugar coating operation was performed by a conventional method to obtain sugar coated tablets A1 having an average weight of 480 mg / tablet.
[0041]
[Example 2]
[0042]
Except for using erythritol [Mitsubishi Chemical Foods Co., Ltd.] without adjusting the particle size in place of xylitol, the same components as in Example 1 were mixed at the blending ratios shown in Table 1, and directly using a rotary tablet press. Tableting was performed to obtain a core agent having an average weight of 320 mg / tablet.
Next, a sugar coating operation was performed in the same manner as in Example 1 except that a maltitol solution was prepared at a blending ratio shown in Table 1, and sugar coated tablets A2 having an average weight of 448 mg / tablet were obtained.
[0043]
[Example 3]
[0044]
Except for using mannitol [manufactured by Towa Kasei Kogyo Co., Ltd., trade name: Mannit P] instead of xylitol without adjusting the particle size, the same components as in Example 1 were mixed in the mixing ratio described in Table 1, Direct tableting was performed with a rotary tableting machine to obtain a core agent having an average weight of 320 mg / tablet.
Next, a sugar coating operation was performed in the same manner as in Example 1 except that a maltitol solution was prepared at the blending ratio shown in Table 1, and sugar coated tablets A3 having an average weight of 576 mg / tablet were obtained.
[0045]
[Example 4]
[0046]
The same components as in Example 1 were mixed at the blending ratio described in Table 1 except that sorbitol [manufactured by Towa Kasei Kogyo Co., Ltd., trade name: Sorbit DP-50] was used without adjusting the particle size instead of xylitol. The tablet was directly compressed by a rotary tableting machine to obtain a core agent having an average weight of 320 mg / tablet.
Next, a sugar coating operation was performed in the same manner as in Example 1 except that a maltitol solution was prepared at a blending ratio shown in Table 1, and sugar coated tablets A4 having an average weight of 512 mg / tablet were obtained.
[0047]
[Example 5]
[0048]
Xylitol [manufactured by Towa Kasei Kogyo Co., Ltd., trade name: Xylit (fine powder)], mannitol [trade name: Mannit P], crystalline maltitol [manufactured by Towa Kasei Kogyo Co., Ltd., trade name: Resis (fine powder), maltitol Purity = 99.0%, sum of contents of maltotriitol and maltotetriitol = 0.5%] without adjusting the particle size, and 1-menthol, vitamin C and HPMC are listed in Table 2. After mixing with 10% of the total weight and pure water sprayed on this, the mixture was extruded with an extrusion granulator (RG-8M-2U manufactured by Kikusui Seisakusho) and dried at 50 ° C. for 8 hours. Next, magnesium stearate (reagent, manufactured by Kanto Chemical Co., Inc.) was added and mixed at the mixing ratio shown in Table 2, and directly tableted with a rotary tableting machine to obtain an average weight of 320 mg / tablet core. Obtained.
[0049]
Next, 1000 tablets of the obtained core agent are put into a small sugar coating machine, and maltitol liquid is prepared at a blending ratio shown in Table 2 using maltitol [trade name: Resis]. On the other hand, a sugar coating operation was performed in the same manner as in Example 1 to obtain sugar coated tablets A5 having an average weight of 512 mg / tablet.
[0050]
[Example 6]
[0051]
Instead of xylitol and mannitol, the same components as in Example 5 were used except that erythritol fine powder [Mitsubishi Chemical Foods Co., Ltd.] and sorbitol [trade name: Sorbit DP-50] were used without adjusting the particle size. After mixing at the compounding ratio described in Table 2, a core agent having an average weight of 320 mg / tablet was obtained in the same manner as in Example 5.
Next, a sugar coating operation was performed in the same manner as in Example 5 except that a maltitol solution was prepared at a blending ratio shown in Table 2, and sugar coated tablets A6 having an average weight of 448 mg / tablet were obtained.
[0052]
[Example 7]
[0053]
Example 5 except that erythritol fine powder [Mitsubishi Chemical Foods Co., Ltd.] and Paratinit [Mitsui Sugar Co., Ltd., trade name: Paratinit PNP (registered trademark)] were used without adjusting the particle size in place of xylitol. After mixing the same components at the blending ratios described in Table 2, a core agent having an average weight of 320 mg / tablet was obtained in the same manner as in Example 5.
Next, a sugar coating operation was performed in the same manner as in Example 5 except that a maltitol solution was prepared at a blending ratio shown in Table 2, and sugar coated tablets A7 having an average weight of 544 mg / tablet were obtained.
[0054]
[Comparative Example 1]
[0055]
Except that crystalline maltitol was not used as the core material, the same components as in Example 1 were mixed at the mixing ratio shown in Table 3, and then the average weight of 320 mg / tablet was obtained in the same manner as in Example 1. A core was obtained.
Next, using crystalline maltitol [trade name: Resis], a maltitol solution was prepared at a blending ratio shown in Table 3, and sugar coating was performed in the same manner as in Example 1 to obtain sugar-coated tablets. However, since the tablet hardness was too low, the tablet was broken during the sugar coating operation, and a sugar-coated tablet could not be obtained. Hereinafter, the tablet obtained in Comparative Example 1 is referred to as B1 for convenience.
[0056]
[Comparative Example 2]
[0057]
After mixing the core material with the compounding ratio shown in Table 3, a core material having a crystalline maltitol content of 4.7% and an average weight of 320 mg / tablet was obtained in the same manner as in Example 1.
Next, a sugar coating operation was performed in the same manner as in Example 1 except that a maltitol solution was prepared at a blending ratio shown in Table 3, and sugar coated tablets B2 having an average weight of 512 mg / tablet were obtained.
[0058]
[Comparative Example 3]
[0059]
After mixing the core material with the blending ratio shown in Table 3, a core material having a crystalline maltitol content of 56.1% and an average weight of 320 mg / tablet was obtained in the same manner as in Example 1.
Next, a sugar coating operation was carried out in the same manner as in Example 1 except that a maltitol solution was prepared at a blending ratio shown in Table 3, and sugar coated tablets B3 having an average weight of 512 mg / tablet were obtained.
[0060]
[Comparative Example 4]
[0061]
After mixing the core material with the blending ratio shown in Table 3, the core material having the total content of component (a) and component (b) of 44.0% and average weight of 320 mg / tablet was obtained in the same manner as in Example 1. Got.
Next, a maltitol solution was prepared with the compounding ratio shown in Table 3, and sugar coating was performed by the same method as in Example 1 to obtain a sugar-coated tablet. Was broken and sugar-coated tablets could not be obtained. Hereinafter, the tablet obtained in Comparative Example 4 is referred to as B4 for convenience.
[0062]
[Comparative Example 5]
[0063]
A core with an average weight of 320 mg / tablet was obtained in the same manner as in Example 1 except that the core material was mixed at the blending ratio shown in Table 4.
Next, a sugar coating operation was performed in the same manner as in Example 1 except that a coating liquid containing no maltitol was prepared with the components and mixing ratios shown in Table 3, and coated tablets B5 having an average weight of 326 mg / tablet were obtained. Obtained.
[0064]
[Comparison test 1]
[0065]
[Food texture (tablet hardness)]
The tablet hardness of the core obtained in each Example and Comparative Example was measured by Test Method A. The measurement was repeated 10 times for one type of sample, and the average values are shown in Tables 5-7.
[0066]
Although the core tablet is not preferred even if it is too hard or brittle, the tablet hardness of the products A1 to A7 of the present invention and the B3 and B5 of the comparative examples is a preferred hardness of 2.2 to 18.5 kg and chewed. At that time, while it was chewable, the comparative examples B1 and B4 were very brittle and were not preferable. Moreover, B2 was too hard to chew easily and was not a preferable texture.
[0067]
[Comparison test 2]
[0068]
[Evaluation of color tone (uneven color)]
Regarding the color unevenness, 10 trained panelists performed visual evaluation of the color uniformity of the sugar-coated tablets for the products A1 to A7 of the present invention and B2, B3, and B5 of the comparative examples.
[0069]
Color tone evaluation was calculated as 3 points: “no color unevenness”, 2 points: “almost no color unevenness”, 1 point: “a little color unevenness”, 0 points “a lot of color unevenness”, The results are as follows: 30 to 26 points as “good” ◎, 25 to 16 points as “slightly good” ○, 15 to 6 points as “slightly bad” Δ, less than 5 points as “bad” × Expressed in B1 and B4 could not be sugar-coated under the implemented conditions, and could not be evaluated.
From the results of this color tone evaluation, it was shown that when the present invention was carried out, the color of the sugar-coated tablet surface was small and the appearance was beautifully finished.
[0070]
[Comparison test 3]
[0071]
[Evaluation of smoothness]
About smoothness, 10 trained panelists performed visually evaluating the unevenness | corrugation on the sugar-coated tablet surface of Examples A1-A7 of this invention and B2, B3, and B5 of a comparative example.
[0072]
The smoothness was evaluated as 3 points: “no unevenness”, 2 points: “almost unevenness”, 1 point: “slightly uneven”, 0 point: “many unevenness”, and the result was 30 Points to 26 are expressed as 平滑 as “smooth”, 25 to 16 as “slightly smooth”, ○ as 15 to 6 as “slightly uneven”, Δ as less than 5 points as “uneven” did.
From the result of this smoothness evaluation, it was shown that when the present invention was carried out, the smoothness of the sugar-coated tablet surface was high and the appearance was beautifully finished.
[0073]
[Comparison test 4]
[0074]
[Evaluation of hygroscopicity]
Prepare two weighing bottles for each sample, put 5 sugar-coated tablets obtained in each Example and Comparative Example, and store for 16 hours at a temperature of 40 ° C. and a relative humidity of 81%. The weight of the sugar-coated tablets Changes were measured. The increased weight was taken as the moisture absorption, and the weight of the original sugar-coated tablet was expressed as a percentage, and the hygroscopicity was evaluated.
From this measurement result, it was shown that when the present invention was carried out, the hygroscopicity was clearly improved.
[0075]
[Comparative test 5]
[0076]
[Evaluation of texture (coolness)]
For the cool feeling, 10 trained panelists evaluated the cool feeling in the mouth felt when chewing the sugar-coated tablets of Examples A1 to A7 of the present invention and Comparative Examples B2, B3, and B5. It was.
[0077]
The evaluation of cool feeling is 3 points: “strong cool feeling”, 2 points: “cool feeling”, 1 point: “cool feeling is weak”, 0 point: “no cool feeling”, and the result 30 ~ 26 points as texture (cool feeling) "Good" ◎, 25 ~ 16 points as texture (cool feeling) "Slightly good" ○, 15 ~ 6 points as texture (cool feeling) “Slightly bad” was indicated by Δ, and “less than 5 points” was expressed as “bad” in texture (cool feeling).
From this measurement result, it was clearly shown that a refreshing and good cooling feeling in the mouth can be obtained when the present invention is carried out.
[0078]
[Comparative test 6]
[0079]
[Evaluation of texture (crunchiness)]
Regarding crunchiness, 10 trained panelists chewed the sugar-coated tablets of Examples A1 to A7 of the present invention and B2, B3, and B5 of Comparative Examples in the mouth, and a crispy texture that can be felt at that time That is, it was performed by evaluating the crunch property.
[0080]
The evaluation of crunch characteristics is 3 points: “Strong crunch property”, 2 points: “Crunch property”, 1 point: “Crunch property is weak”, 0 point: “No crunch property”, and the result 30 to 26 points are ◎ with a texture (crunchiness) of “good”, 25 to 16 points are mouthfeel (crunchiness) “slightly good”, and 15 to 6 points are texture (crunchiness) “Slightly bad” was indicated by Δ, and less than 5 points were expressed as “bad” in texture (crunchiness).
From this measurement result, it was shown that when the present invention was carried out, clearly good crunch properties were obtained.
[0081]
[Table 1]
Figure 0004336074
[0082]
[Table 2]
Figure 0004336074
[0083]
[Table 3]
Figure 0004336074
[0084]
[Table 4]
Figure 0004336074
[0085]
[Table 5]
Figure 0004336074
[0086]
[Table 6]
Figure 0004336074
[0087]
[Table 7]
Figure 0004336074

Claims (2)

成分(a)および成分(b)の混合物を50.0重量%以上含有する芯剤に、着色料を含有した固形分濃度50.0〜80.0重量%のマルチトール液で糖衣を施すことにより得られる、色調および食感が良好な硬質糖衣錠剤。
成分(a):結晶性マルチトール10.0〜50.0重量%
成分(b):キシリトール、エリスリトール、マンニトール、ソルビトールからなる群から選ばれる1種もしくは2種以上の混合物である結晶性粉末50.0〜90.0重量%
Applying sugar coating to a core containing 50.0% by weight or more of a mixture of component (a) and component (b) with a maltitol liquid containing a colorant and having a solid content concentration of 50.0 to 80.0% by weight Hard-coated tablet with good color and texture obtained by
Component (a): crystalline maltitol 10.0-50.0% by weight
Component (b): Crystalline powder 50.0-90.0% by weight which is one or a mixture of two or more selected from the group consisting of xylitol, erythritol, mannitol, sorbitol
試験法Aによる芯剤の硬度が1.5〜20.0kgである請求項1記載の色調および食感が良好な硬質糖衣錠剤。  The hard sugar-coated tablet with good color tone and texture according to claim 1, wherein the hardness of the core agent according to Test Method A is 1.5 to 20.0 kg.
JP2001388506A 2001-11-15 2001-11-15 Hard sugar-coated tablets with good color and texture Expired - Fee Related JP4336074B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2001388506A JP4336074B2 (en) 2001-11-15 2001-11-15 Hard sugar-coated tablets with good color and texture

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2001388506A JP4336074B2 (en) 2001-11-15 2001-11-15 Hard sugar-coated tablets with good color and texture

Publications (2)

Publication Number Publication Date
JP2003155226A JP2003155226A (en) 2003-05-27
JP4336074B2 true JP4336074B2 (en) 2009-09-30

Family

ID=19188186

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001388506A Expired - Fee Related JP4336074B2 (en) 2001-11-15 2001-11-15 Hard sugar-coated tablets with good color and texture

Country Status (1)

Country Link
JP (1) JP4336074B2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1615626T3 (en) * 2003-04-24 2010-02-08 Jagotec Ag Colored core tablet
JP2006050925A (en) * 2004-08-10 2006-02-23 Nikken Kasei Kk Tablet confectionery and tablet
ES2367076T3 (en) * 2004-09-30 2011-10-28 The Hershey Company SEALED COMPOSITE PACKS OF EDIBLE FILM STRIPS AND MANUFACTURING AND USING PROCEDURES OF THE SAME.
PE20070077A1 (en) * 2005-06-10 2007-02-07 Takeda Pharmaceutical COMPRESSED WITH SUGAR COATED
JP4775312B2 (en) * 2007-04-27 2011-09-21 三菱商事フードテック株式会社 Granules and tablets for direct compression
JP2012067241A (en) * 2010-09-27 2012-04-05 Riken Vitamin Co Ltd Method for producing gardenia blue pigment

Also Published As

Publication number Publication date
JP2003155226A (en) 2003-05-27

Similar Documents

Publication Publication Date Title
US6060078A (en) Chewable tablet and process for preparation thereof
JP3649990B2 (en) Sugar-free sugar coating products
EP0431376B1 (en) Hard confections containing hydrogenated isomaltulose and a medicinally active ingredient
KR101047248B1 (en) Hard sugar coated preparations sugar coating solutions and process for producing hard sugar coated preparation
KR101321452B1 (en) Resin encapsulated high intensity sweetener
RU2455974C2 (en) Product for oral cavity care and chewing gum (versions)
CN102958379B (en) Chewing gum with pretreated polyols
Pothu et al. Lozenges formulation and evaluation: A review
JPH0126661B2 (en)
HU210933B (en) Process for producing pharmaceutical compositions comprising l-carnitine
JPS6371151A (en) Chewing gum mineral auxiliary agent
AU728731B2 (en) Sugar-free dragee chewing sweets
AU2007233366A1 (en) Film-coated solid dosage forms
CN107708444A (en) Contain the edible composition for stabilizing natural colorant
JP4336074B2 (en) Hard sugar-coated tablets with good color and texture
RU2664300C2 (en) Coated chewing gum with hard caramel layer
US20080299250A1 (en) Chewing Gum Composition Containing Chokeberry
JP5195623B2 (en) Tablet confectionery
JP2012170328A (en) Sugar-coated confectionery
JP4379179B2 (en) Fast dissolving tablet confectionery with cooling sensation and method for producing the same
JP2004107282A (en) Method of inhibiting crystallization of erythritol
KR100254805B1 (en) Chewable tablet and method of preparation thereof
KR100384392B1 (en) Chewing gum with center-filling of agglomerated erythritol and the process thereof
JP4998301B2 (en) Sugar confectionery
JPH10130140A (en) Production of gummy pharmaceutical preparation

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20041105

RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20070403

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080708

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080826

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20081125

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20090623

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20090626

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120703

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Ref document number: 4336074

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120703

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20150703

Year of fee payment: 6

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees