JP4520912B2 - Diamine derivatives, process for producing the same, and fungicides containing them as active ingredients - Google Patents

Description

  The present invention relates to a novel diamine derivative, a method for producing the same, and a fungicide containing these as active ingredients.

  Disease control plays a major role in crop cultivation, and various fungicides have been developed and used. However, there is not always enough in the bactericidal activity and the harm to useful crops. Also, in recent years, resistant bacteria to drugs have emerged due to heavy use of agricultural and horticultural fungicides, and existing drugs may not exhibit sufficient activity. Furthermore, there is a need for new fungicides that are safe and can control harmful bacteria at low concentrations due to environmental problems. It has been disclosed in WO03008372 that diamine derivatives are useful as pest control agents so far. However, while WO03008372 shows a control activity only for rice blast, the diamine derivative of the compound of the present invention has a broad spectrum of disease control, and the structure is also different from the compounds described in the gazette.

International Publication No. 00/3008372 Pamphlet (2000)

  An object of the present invention is to provide a new agricultural and horticultural fungicide that exhibits a broad disease control spectrum against pathogenic bacteria of various crops and solves the problem of resistant bacteria that is currently becoming more serious.

  The inventors of the present invention synthesized various diamine derivatives and examined their physiological activities. As a result, the compounds of the present invention have a broad spectrum of disease control, have extremely excellent bactericidal activity, and do no harm to useful crops. As a result, the present invention was completed.

That is, the present invention is as follows.
[1]. Formula (1) (Formula 1)

[In the formula, R1 is an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, a cycloalkenyl group having 3 to 6 carbon atoms, or a group having 2 to 6 carbon atoms. An alkynyl group, an aryl group, a heterocyclic ring, an arylalkyl group having 1 to 6 carbon atoms in the alkyl group, or a heterocyclic alkyl group having 1 to 6 carbon atoms in the alkyl group; R2 and R5 are each independently hydrogen; Atom, alkyl group having 1 to 6 carbon atoms, cycloalkyl group having 3 to 6 carbon atoms, alkenyl group having 2 to 6 carbon atoms, cycloalkenyl group having 3 to 6 carbon atoms, alkynyl group having 2 to 6 carbon atoms, acyl A group, an aryl group, a heterocycle, an arylalkyl group having 1 to 6 carbon atoms in the alkyl group, or a heterocyclic alkyl group having 1 to 6 carbon atoms in the alkyl group, and R3 and R4 are each independently a hydrogen atom. , Carbon number 1 Alkyl group, cycloalkyl group having 3 to 6 carbon atoms, alkenyl group having 2 to 6 carbon atoms, cycloalkenyl group having 3 to 6 carbon atoms, alkynyl group having 2 to 6 carbon atoms, aryl group, heterocycle, alkyl group Represents an arylalkyl group having 1 to 6 carbon atoms, or a heterocyclic alkyl group having 1 to 6 carbon atoms, or R3 and R4 are bonded to each other to form a hydrocarbon ring having 3 to 6 carbon atoms. R6, R7, R8 and R9 may each independently form a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, A C3-C6 cycloalkenyl group, a C2-C6 alkynyl group, an aryl group, a heterocycle, an alkyl group having 1-6 carbon atoms, or an alkyl group having 1-6 carbon atoms Heterocycle A Represents a kill group, provided that at least one of R6, R7, R8 and R9 is an aryl group, a heterocycle, an arylalkyl group having 1 to 6 carbon atoms in an alkyl group, or an alkyl group having 1 to 6 carbon atoms. Represents a heterocyclic alkyl group, or a pair of R6 and R7 or R8 and R9 may be bonded to each other to form a hydrocarbon ring having 3 to 6 carbon atoms, and R10 represents a hydrogen atom, 6 represents an alkyl group, a cycloalkyl group having 3 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, a cycloalkenyl group having 3 to 6 carbon atoms, an alkynyl group having 2 to 6 carbon atoms, an acyl group, Represents an oxygen atom or a sulfur atom, and Q represents an aryl group or a heterocyclic ring. ] The diamine derivative represented by this.

[2]. A fungicide containing the diamine derivative according to the above [1] as an active ingredient.

[3]. Formula (2) (Formula 2)

[Wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and A represent the same meaning as [1]. The compound represented by formula (3)

[Wherein Q represents the same meaning as [1], and X represents a leaving group. ] The manufacturing method of the diamine derivative as described in [1] characterized by reacting with the compound represented by this.

[4]. The compound represented by the formula (2) (Chemical formula 2) is converted into the formula (4) (Chemical formula 4).

[Wherein Q represents the same meaning as [1]. ] The manufacturing method of the diamine derivative as described in [1] characterized by reacting with the compound represented by this.

[5]. Formula (5) (Formula 5)

[Wherein R5, R6, R7, R8, R9, R10 and Q represent the same meaning as [1]. The compound represented by formula (6)

[Wherein, R1, R2, R3, R4 and A represent the same meaning as [1], and X represents a leaving group. ] The manufacturing method of the diamine derivative as described in [1] characterized by reacting with the compound represented by this.

[6]. The compound represented by the formula (5) (Chemical formula 5) is converted to the formula (7) (Chemical formula 16).

[Wherein R1, R2, R3, R4 and A represent the same meaning as [1]. ] The manufacturing method of the diamine derivative as described in [1] characterized by reacting with the compound represented by this.

[7]. Formula (8) (Formula 8)

[Wherein R 2, R 3, R 4, R 5, R 6, R 7, R 8, R 9, R 10 and Q represent the same meaning as [1]. The compound represented by formula (9)

[Wherein, R1 and A represent the same meaning as [1], and X represents a leaving group. ] The manufacturing method of the diamine derivative as described in [1] characterized by reacting with the compound represented by this.

[8]. [1] A composition for controlling pests comprising the diamine derivative according to [1] and at least one other fungicide and / or insecticide.

  The diamine derivative according to the present invention is useful as an agricultural fungicide because it has a broad bactericidal spectrum, has extremely excellent bactericidal activity, and has no harmful effect on useful crops. The diamine derivative according to the present invention has a high control effect against tomato blight, potato blight, cucumber downy mildew, grape downy mildew, and rice blast. Moreover, in addition to the above-mentioned diseases, it is effective against Pythium spp. In addition, it has the characteristics of excellent penetration, residual effect, and rain resistance without causing phytotoxicity to crops.

The present invention is described in detail below.
In the diamine derivative represented by the formula (1) and the method for producing the same, examples of typical substituents include, but are not limited to, the following. Examples of the alkyl group having 1 to 6 carbon atoms include a methyl group, an ethyl group, a propyl group, a butyl group, a pentyl group, and a hexyl group. These may be substituted with a substituent, and have 3 to 6 carbon atoms. Examples of the cycloalkyl group include a cyclopropyl group, a cyclobutyl group, a cyclopentyl group, a cyclohexyl group, and the like. These may be substituted with a substituent. Examples of the alkenyl group having 2 to 6 carbon atoms include a vinyl group and a propenyl group. Group, butenyl group, pentenyl group, hexenyl group and the like, which may be substituted by a substituent, and examples of the cycloalkenyl group having 3 to 6 carbon atoms include a cyclopropenyl group, a cyclobutenyl group, a cyclopentenyl group, A cyclohexenyl group and the like, which may be substituted by a substituent, and an alkynyl having 2 to 6 carbon atoms. Examples of the group include an ethynyl group, a propynyl group, a butynyl group, a pentynyl group, a hexynyl group, and the like. These may be substituted with a substituent, and examples of the aryl group include a phenyl group and a naphthyl group. These may be substituted with a substituent, and the heterocycle represents a C1-C15 heterocycle containing at least one of at least one of a nitrogen atom, an oxygen atom and a sulfur atom. , Thiophene, oxazole, pyrrole, 1H-pyrazole, 3H-pyrazole, imidazole, thiazole, oxazole, isoxazole, isothiazole, [1,2,3] oxadiazole, [1,2,4] oxadiazole, [1 , 3,4] oxadiazole, furazane, [1,2,3] thiadiazole, [1,2,4] thiadia [1,2,5] thiadiazole, [1,3,4] thiadiazole, 1H- [1,2,3] triazole, 2H- [1,2,3] triazole, 1H- [1,2, 4] triazole, 2H- [1,2,4] triazole, 1H-tetrazole, 5H-tetrazole, 2,3-dihydro-1H-pyrrole, 2,5-dihydro-1H-pyrrole, 3,4-dihydro-2H -Pyrrole, pyrrolidine, 2,3-dihydrofuran, 2,5-dihydrofuran, tetrahydrofuran, 2,3-dihydrothiophene, 2,5-dihydrothiophene, tetrahydrothiophene, pyrazolidine, pyridine, pyran, thiopyran, pyridazine, pyrimidine, Pyrazine, [1,2,3] triazine, [1,2,4] triazine, [1,3,5] triazine, 2H— [1,2,3] oxadiazine, 2H- [1,2,4] oxadiazine, 2H- [1,2,5] oxadiazine, 2H- [1,2,6] oxadiazine, 4H- [1,2,3 ] Oxadiazine, 4H- [1,2,4] oxadiazine, 4H- [1,2,5] oxadiazine, 4H- [1,2,6] oxadiazine, 4H- [1,3,4] oxadiazine, 4H- [ 1,3,5] oxadiazine, 2H- [1,2,3] thiadiazine, 2H- [1,2,4] thiadiazine, 2H- [1,2,5] thiadiazine, 2H- [1,2,6] Thiadiazine, 4H- [1,2,3] thiadiazine, 4H- [1,2,4] thiadiazine, 4H- [1,2,5] thiadiazine, 4H- [1,2,6] thiadiazine, 4H- [1 , 3,4] thiadiazine, 4H- 1,3,5] thiadiazine, 2,3-dihydropyridine, 3,4-dihydropyridine, 1,3-dioxane, 1,4-dioxane, piperidine, 3,4-dihydro-2H-pyran, 3,6-dihydro- 2H-pyran, tetrahydropyran, 3,4-dihydro-2H-thiopyran, 3,6-dihydro-2H-thiopyran, tetrahydrothiopyran, morpholine, piperazine, chroman, chromene, isobenzofuran, indolizine, indole, 3H-indole , Dihydroindole, isoindole, 1H-indazole, 2H-indazole, purine, quinoline, isoquinoline, 4H-quinolidine, phthalazine, naphthyridine, quinoxaline, quinazoline, cinnoline, carbazole, acridine, phenazine, phenanthroline, fur Nothiazine, phenoxazine, indoline, isoindoline, benzofuran, dihydrobenzofuran, benzothiophene, benzo [c] thiophene, benzo [c] isothiazole, benzo [c] isoxazole, dihydrobenzothiophene, benzoxazole, benzisoxazole, Benzimidazole, benzothiazole, benzoisothiazole, 1H-benzotriazole, 2H-benzotriazole, benzo [1,4] dioxane, 2,3-dihydrobenzo [1,4] dioxane, benzo [1,3] dioxole, β -Carboline, benzo [1,2,5] oxadiazole, benzo [1,2,5] thiadiazole, pteridine, imidazo [1,2-a] pyridine, imidazo [1,2-a] pyrimidine, pyrazolo [1 , 5-a] Midine, [1,2,4] triazolo [1,5-a] pyrimidine and the like, which may be substituted by a substituent, and the acyl group includes an alkylcarbonyl group such as an acetyl group or a benzoyl group And the like, and these may be substituted with a substituent. Examples of the substituent for the alkyl group having 1 to 6 carbon atoms include an alkyl group such as a methyl group, an ethyl group, a propyl group or a butyl group, a cycloalkyl group such as a cyclopropyl group, a cyclobutyl group, a cyclopentyl group or a cyclohexyl group, and trifluoro Halogen-substituted alkyl groups such as methyl group, difluoromethyl group, bromodifluoromethyl group or trifluoroethyl group, alkoxy groups such as methoxy group, ethoxy group, propoxy group or butoxy group, trifluoromethoxy group, difluoromethoxy group or trifluoro Halogen-substituted alkoxy groups such as ethoxy groups, halogen-substituted alkoxy groups such as methylthio groups, ethylthio groups, propylthio groups or butylthio groups, alkylthio groups such as trifluoromethylthio groups, difluoromethylthio groups or trifluoroethylthio groups Alkylsulfinyl groups such as ruthio group, methanesulfinyl group, ethanesulfinyl group, propanesulfinyl group or butanesulfinyl group, halogen-substituted alkylsulfinyl groups such as trifluoromethanesulfinyl group, difluoromethanesulfinyl group or trifluoroethanesulfinyl group, methanesulfonyl group , Sulfonylsulfonyl group, alkylsulfonyl group such as propanesulfonyl group or butanesulfonyl group, halogen-substituted alkylsulfonyl group such as trifluoromethanesulfonyl group, difluoromethanesulfonyl group or trifluoroethanesulfonyl group, methanesulfonamide group, ethanesulfonamide group , Alkylsulfonamide groups such as propanesulfonamide group or butanesulfonamide group, trifluoromethane A halogen-substituted alkylsulfonamide group such as a sulfonamide group, a difluoromethanesulfonamide group or a trifluoroethanesulfonamide group, an aminomethyl group such as a methylamino group, a phenylaminomethyl group, or an aminomethyl group, an acetylamino group, or a benzoyl group; Examples of the amide group such as an amino group include a fluorine atom, a chlorine atom, a halogen atom such as a bromine atom or an iodine atom, an acyl group such as an acetyl group or a benzoyl group, and an alkyl group having 1 to 6 carbon atoms is an aryl group Or the case where it is substituted by a heterocycle is not included. The number of carbon atoms in the cycloalkyl group having 3 to 6 carbon atoms, the alkenyl group having 2 to 6 carbon atoms, the cycloalkenyl group having 3 to 6 carbon atoms, the alkynyl group having 2 to 6 carbon atoms, the aryl group, the heterocycle, and the alkyl group. Examples of the substituent of the arylalkyl group having 1 to 6 or the heterocyclic alkyl group having 1 to 6 carbon atoms of the alkyl group include alkyl groups such as methyl group, ethyl group, propyl group, and butyl group, cyclopropyl group, and cyclobutyl. Group, cycloalkyl group such as cyclopentyl group or cyclohexyl group, halogen-substituted alkyl group such as trifluoromethyl group, difluoromethyl group, bromodifluoromethyl group or trifluoroethyl group, methoxy group, ethoxy group, propoxy group or butoxy group Alkoxy group, trifluoromethoxy group, difluoromethoxy group or trifluoro Halogen-substituted alkoxy groups such as ethoxy groups, alkylthio groups such as methylthio groups, ethylthio groups, propylthio groups or butylthio groups, halogen-substituted alkylthio groups such as trifluoromethylthio groups, difluoromethylthio groups or trifluoroethylthio groups, methanesulfinyl groups, Alkylsulfinyl groups such as ethanesulfinyl group, propanesulfinyl group or butanesulfinyl group, halogen-substituted alkylsulfinyl groups such as trifluoromethanesulfinyl group, difluoromethanesulfinyl group or trifluoroethanesulfinyl group, methanesulfonyl group, ethanesulfonyl group, propanesulfonyl Group or alkylsulfonyl group such as butanesulfonyl group, trifluoromethanesulfonyl group, difluoromethanesulfonyl group Is a halogen-substituted alkylsulfonyl group such as trifluoroethanesulfonyl group, alkylsulfonamide group such as methanesulfonamide group, ethanesulfonamide group, propanesulfonamide group or butanesulfonamide group, trifluoromethanesulfonamide group, difluoromethanesulfonamide Group or halogen-substituted alkylsulfonamide group such as trifluoroethanesulfonamide group, aryl group such as phenyl group or naphthyl group, furan, thiophene, oxazole, pyrrole, 1H-pyrazole, 3H-pyrazole, imidazole, thiazole, oxazole, isoxazole Heterocycles such as isothiazole, tetrahydrofuran, pyrazolidine, pyridine, pyran, pyrimidine, pyrazine, etc. Group, aminomethyl group such as aminomethyl group, amide group such as acetylamino group or benzoylamino group, halogen atom of fluorine atom, chlorine atom, bromine atom or iodine atom, acetyl group or benzoyl group Each acyl group can be exemplified.

  In the compounds represented by formula (3), formula (6) and formula (9), the leaving group represented by X is represented by a halogen atom represented by a chlorine atom, a methoxy group and an ethoxy group. Aryloxy groups typified by alkoxy groups, phenoxy groups, acyloxy groups typified by acetyloxy groups and benzoyloxy groups, alkoxycarbonyloxy groups typified by methoxycarbonyloxy groups, arylcarbonyl typified by phenylcarbonyloxy groups Examples thereof include an oxy group, N-hydroxysuccinimide, 1-hydroxybenzotriazole, and an imidazole group.

  The compound of the present invention represented by the formula (1) is a novel compound, and the compound represented by the formula (1) can be produced by the method described in the reaction formula (1) (chemical formula 10).

[Wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and A represent the same meaning as in Formula (2) (Chemical Formula 2), and Q and X represent Formula (3) (Chemical Formula (3) It represents the same meaning as 3). ]

  In the reaction formula (1), the amine derivative represented by the formula (2) and the salt thereof are mixed with the known carbonyl compound represented by the formula (3) in a solvent-free or solvent-free, base-free or base, trialkylaluminum, etc. By reacting in the presence of a metal reagent, a diamine derivative represented by the formula (1) can be produced.

  Bases used in the reaction represented by the reaction formula (1) include alkali metal hydroxides such as sodium hydroxide and potassium hydroxide, alkaline earth metal hydroxides such as magnesium hydroxide and calcium hydroxide, hydrogen Alkali metal hydrides such as sodium hydride and potassium hydride; alkali metal alcoholates such as sodium methoxide and sodium ethoxide; alkali metal oxides such as sodium oxide; carbonates such as potassium carbonate and sodium carbonate; Phosphate salts such as potassium, trisodium phosphate, dipotassium monohydrogen phosphate, disodium monohydrogen phosphate, acetates such as sodium acetate and potassium acetate, pyridine, 4- (dimethylamino) pyridine, triethylamine, imidazole, diazabicyclone Examples include organic bases such as decene.

  The amount of these bases to be used is not particularly limited, and can be used as a solvent when the above organic bases are used.

  When these bases are used, the solvent used in the reaction includes water, alcohols such as methanol, ethanol, propanol and butanol, halogenated hydrocarbons such as dichloromethane and chloroform, and aromatics such as benzene, toluene and xylene. Hydrocarbons, aliphatic hydrocarbons such as hexane and heptane, dimethylformamide (DMF), dimethylacetamide (DMA), dimethylsulfoxide (DMSO), 1,3-dimethyl-2-imidazolidinone (DMI), 1- Aprotic polar solvents such as methyl-2-pyrrolidone (NMP), ethers such as ethyl ether, isopropyl ether, 1,2-dimethoxyethane (DME), tetrahydrofuran (THF), dioxane, acetonitrile, propionitrile, etc. List nitriles Door can be.

  Examples of the metal reagent used in the reaction represented by the reaction formula (1) include alkylaminomagnesium halide (Bodrux reaction) made from Grignard reagent and alkylamine, lithium aluminum hydride, trimethylaluminum, triethylaluminum, and the like. be able to. The amount of these metal reagents used is not particularly limited.

  When using these metal reagents, the solvents used for the reaction include halogenated hydrocarbons such as dichloromethane and chloroform, aromatic hydrocarbons such as benzene, toluene and xylene, and aliphatic hydrocarbons such as hexane and heptane. And ethers such as ethyl ether, isopropyl ether, 1,2-dimethoxyethane (DME), tetrahydrofuran (THF) and dioxane.

  The reaction temperature and reaction time for the above reaction can be varied over a wide range. In general, the reaction temperature is preferably -78 to 200 ° C, more preferably -78 to 100 ° C, and the reaction time is preferably 0.01 to 50 hours, more preferably 0.1 to 15 hours.

  The equivalent of the carbonyl compound represented by the formula (3) is preferably 1 to 2 equivalents, more preferably 1 to 1.2 equivalents with respect to the amine derivative represented by the formula (2).

  The amine derivative represented by the formula (2) of the reaction formula (1) and a salt thereof can be produced by the method described in the reaction formula (2) (Chemical Formula 11).

[Wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and A represent the same meaning as in formula (2) (Chemical Formula 2), and R11 represents a t-butyl group or substituted Represents a good benzyl group. ]

  In the reaction formula (2), the diamine derivative represented by the formula (2) can be produced by reacting the diamine derivative represented by the formula (10) with an acid or by hydrogenation reaction.

  As the acid in this case, hydrogen chloride, hydrogen bromide, sulfuric acid, nitric acid, acetic acid, trifluoroacetic acid and the like can be used. The amount of these acids used is not particularly limited, and can be used as a solvent.

  The hydrogenation reaction can be carried out in a suitable solvent, in the presence of a catalyst, at normal pressure or under pressure, in a hydrogen atmosphere. Examples of the catalyst include a palladium catalyst such as palladium-carbon, a nickel catalyst such as Raney nickel, a cobalt catalyst, a ruthenium catalyst, a rhodium catalyst, a platinum catalyst, and the like. Examples of the solvent include water, alcohols such as methanol and ethanol, benzene, Aromatic hydrocarbons such as toluene, chain or cyclic ethers such as ether, dioxane and tetrahydrofuran, and esters such as ethyl acetate can be used. The reaction temperature and reaction time for the above reaction can be varied over a wide range. In general, the reaction temperature may be appropriately selected from −20 ° C. to the reflux temperature of the solvent to be used, and the reaction time in the range of several minutes to 96 hours.

  The diamine derivative represented by the formula (10) of the reaction formula (2) and the salt thereof can be produced by the method described in the reaction formula (3) (Chemical Formula 12).

[Wherein R1, R2, R3, R4, A and X represent the same meaning as in formula (6) (Chemical formula 6), and R5, R6, R7, R8, R9, R10 and R11 are the same as in formula (10). Represents meaning. ]

  In the reaction formula (3), the amine derivative represented by the formula (11) and a salt thereof are mixed with a known amino acid derivative represented by the formula (6) in a solvent-free or solvent-free, abasic or base, trialkylaluminum, etc. By reacting in the presence of a metal reagent, a diamine derivative represented by the formula (10) can be produced.

  Moreover, as a base in this case, the thing similar to what is used by the method shown by Reaction formula (1) can be used. The amount of these bases to be used is not particularly limited, and can be used as a solvent when the above organic bases are used.

  Moreover, as a metal reagent in this case, the thing similar to what is used by the method shown by Reaction formula (1) can be used. The amount of these metal reagents used is not particularly limited.

  Moreover, as an organic solvent in this case, the thing similar to what is used by the method shown by Reaction formula (1) can be used.

  The usage-amount of the compound represented by Formula (6) is 1-4 equivalent with respect to the amine derivative represented by Formula (11), Preferably it is 1-2 equivalent.

  The reaction temperature and reaction time for the above reaction can be varied over a wide range. Generally, the reaction temperature is -20 to 200 ° C, preferably 0 to 100 ° C. The reaction time is 0.01 to 50 hours, preferably 0.1 to 15 hours.

  The compound represented by the formula (6) in the reaction formula (3) is obtained by converting the amino acid derivative represented by the formula (7) into thionyl chloride, oxalyl chloride, phosgene, phosphorus oxychloride, phosphorus trichloride, phosphorus pentachloride, odor It can be produced by a conventional method of reacting with thionyl bromide, phosphorus tribromide, diethylaminosulfur trifluoride, 1,1′-carbonylbis-1H-imidazole and the like.

  The compound represented by the formula (6) in the reaction formula (3) is to react the amino acid derivative represented by the formula (7) with alcohols such as methyl alcohol and ethyl alcohol, and phenols such as phenol and nitrophenol. It can also be produced by a conventional method.

  The compound represented by the formula (6) in the reaction formula (3) can be produced by a conventional method in which the amino acid derivative represented by the formula (7) is reacted with chloroformate esters such as methyl chloroformate and phenyl chloroformate. it can.

  The compound represented by the formula (6) in the reaction formula (3) can also be produced by a conventional method in which the amino acid derivative represented by the formula (7) is reacted with N-hydroxysuccinimide, 1-hydroxybenzotriazole and the like. it can.

  The amine derivative represented by the formula (11) of the reaction formula (3) and its salt are those other than those commercially available, such as Gabriel method, delpin method, reduction of cyano group, amide, imine, oxime, etc. It can be easily produced by a known amine synthesis method or a method described in Tetrahedron Asymmetry, Vol. 11, page 1907 (2000).

  The diamine derivative represented by Formula (10) can also be produced by the method described in Reaction Formula (4) (Chemical Formula 13).

[Wherein R1, R2, R3, R4 and A have the same meaning as in formula (7) (Chemical Formula 7), and R5, R6, R7, R8, R9, R10 and R11 have the same meaning as in formula (10). To express. ]

  In the reaction formula (4), the amine derivative represented by the formula (11) and a salt thereof are reacted with the known amino acid derivative represented by the formula (7) in the absence of a solvent or in a solvent to obtain a formula (10) The diamine derivative represented can be produced.

  As the condensing agent in this case, N, N′-dicyclohexylcarbodiimide, 1,1′-carbonylbis-1H-imidazole, 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide / hydrochloride, 2-chloro-1 , 3-dimethylimidazolium chloride and the like can be used.

  The usage-amount of a condensing agent is 1-3 equivalent with respect to the compound represented by Formula (7), Preferably it is 1-1.5 equivalent.

  Moreover, as an organic solvent in this case, the thing similar to what is used by the method shown by Reaction formula (1) can be used.

  The usage-amount of the carboxylic acid derivative represented by Formula (7) is 1-2 equivalent with respect to the amine derivative represented by Formula (11), Preferably it is 1-1.2 equivalent.

  The reaction temperature and reaction time for the above reaction can be varied over a wide range. Generally, the reaction temperature is -20 to 200 ° C, preferably 0 to 100 ° C. The reaction time is 0.01 to 50 hours, preferably 0.1 to 15 hours.

  The compound represented by the formula (7) of the reaction formula (4) is a conventional method in which a corresponding amino acid is reacted with a chloroformate such as a chloroformate or a carbonate such as O-methyl-O- (p-nitrophenyl) carbonate. Can be manufactured.

  The compound represented by the formula (3) in the reaction formula (1) is obtained by converting a known carboxylic acid derivative represented by the formula (4) into thionyl chloride, oxalyl chloride, phosgene, phosphorus oxychloride, phosphorus trichloride, pentachloride. It can be produced by a conventional method of reacting with phosphorus, thionyl bromide, phosphorus tribromide, diethylaminosulfur trifluoride, 1,1′-carbonylbis-1H-imidazole or the like.

  The compound represented by the formula (3) of the reaction formula (1) is obtained by combining a known carboxylic acid derivative represented by the formula (4) with alcohols such as methyl alcohol and ethyl alcohol, phenols such as phenol and nitrophenol. It can also be produced by a conventional method of reacting.

  The compound represented by Formula (3) of Reaction Formula (1) is a conventional method in which a known carboxylic acid derivative represented by Formula (4) is reacted with chloroformate esters such as methyl chloroformate and phenyl chloroformate. Can also be manufactured.

  The compound represented by the formula (3) in the reaction formula (1) is prepared by reacting a known carboxylic acid derivative represented by the formula (4) with N-hydroxysuccinimide, 1-hydroxybenzotriazole, or the like. Can also be manufactured.

  The compound of the present invention represented by Formula (1) can also be produced by the method described in Reaction Formula (5) (Chemical Formula 14).

[Wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and A represent the same meaning as in formula (2) (Chemical Formula 2), and Q represents the formula (3) (Chemical Formula 3). Means the same. In the reaction formula (5), the amine derivative represented by the formula (2) and a salt thereof are reacted with the known carboxylic acid derivative represented by the formula (4) in the absence of a solvent or in a solvent to obtain the formula (1). The diamine derivative represented by this can be manufactured.

  As the condensing agent in this case, N, N′-dicyclohexylcarbodiimide, 1,1′-carbonylbis-1H-imidazole, 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide / hydrochloride, 2-chloro-1 , 3-dimethylimidazolium chloride and the like can be used.

  The usage-amount of a condensing agent is 1-3 equivalent with respect to the compound represented by Formula (4), Preferably it is 1-1.5 equivalent.

  Moreover, as an organic solvent in this case, the thing similar to what is used by the method shown by Reaction formula (1) can be used.

  The usage-amount of the carboxylic acid derivative represented by Formula (4) is 1-2 equivalent with respect to the amine derivative represented by Formula (2), Preferably it is 1-1.2 equivalent.

  The reaction temperature and reaction time for the above reaction can be varied over a wide range. Generally, the reaction temperature is -20 to 200 ° C, preferably 0 to 100 ° C. The reaction time is 0.01 to 50 hours, preferably 0.1 to 15 hours.

  The compound of this invention represented by Formula (1) can also be manufactured by the method as described in Reaction Formula (6) (Chemical Formula 15).

[Wherein R5, R6, R7, R8, R9, R10 and Q represent the same meaning as in formula (5) (Chemical Formula 5), and R1, R2, R3, R4, A and X represent formula (6) (Chemical Formula (6) It represents the same meaning as 15). ]

  In the reaction formula (6), the amine derivative represented by the formula (5) and a salt thereof are converted to a known compound represented by the formula (6) and a metal such as a base or a base and a trialkylaluminum in a solvent or solvent. By reacting in the presence of a reagent, a diamine derivative represented by the formula (1) can be produced.

  Moreover, as a base in this case, the thing similar to what is used by the method shown by Reaction formula (1) can be used. The amount of these bases to be used is not particularly limited, and can be used as a solvent when the above organic bases are used.

  Moreover, as a metal reagent in this case, the thing similar to what is used by the method shown by Reaction formula (1) can be used. The amount of these metal reagents used is not particularly limited.

  Moreover, as an organic solvent in this case, the thing similar to what is used by the method shown by Reaction formula (1) can be used.

  The usage-amount of the compound represented by Formula (6) is 1-4 equivalent with respect to the amine derivative represented by Formula (5), Preferably it is 1-2 equivalent.

  The reaction temperature and reaction time for the above reaction can be varied over a wide range. Generally, the reaction temperature is -20 to 200 ° C, preferably 0 to 100 ° C. The reaction time is 0.01 to 50 hours, preferably 0.1 to 15 hours.

  The compound of this invention represented by Formula (1) can also be manufactured by the method as described in Reaction Formula (7) (Chemical Formula 16).

[Wherein R5, R6, R7, R8, R9, R10 and Q represent the same meaning as in formula (5) (Chemical formula 5), and R1, R2, R3, R4 and A represent formula (7) (Chemical formula 7) Means the same. ]

  In the reaction formula (7), the amine derivative represented by the formula (5) and a salt thereof are reacted with the known carboxylic acid derivative represented by the formula (7) in the absence of a solvent or in a solvent to obtain the formula (1). The diamine derivative represented by these can be manufactured.

  As the condensing agent in this case, N, N′-dicyclohexylcarbodiimide, 1,1′-carbonylbis-1H-imidazole, 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide / hydrochloride, 2-chloro-1 , 3-dimethylimidazolium chloride and the like can be used.

  The usage-amount of a condensing agent is 1-3 equivalent with respect to the compound represented by Formula (7), Preferably it is 1-1.5 equivalent.

  Moreover, as an organic solvent in this case, the thing similar to what is used by the method shown by Reaction formula (1) can be used.

  The usage-amount of the carboxylic acid derivative represented by Formula (7) is 1-2 equivalent with respect to the amine derivative represented by Formula (5), Preferably it is 1-1.2 equivalent.

  The reaction temperature and reaction time for the above reaction can be varied over a wide range. Generally, the reaction temperature is -20 to 200 ° C, preferably 0 to 100 ° C. The reaction time is 0.01 to 50 hours, preferably 0.1 to 15 hours.

  The compound of the present invention represented by the formula (1) can also be produced by the method described in the reaction formula (8) (chemical formula 17).

[Wherein R 2, R 3, R 4, R 5, R 6, R 7, R 8, R 9, R 10 and Q represent the same meaning as in formula (8) (Chemical Formula 8); Means the same. ]

  In reaction formula (8), the amine derivative represented by formula (8) and a salt thereof are reacted with a known compound represented by formula (9) in the absence of a base or a base in the absence of a solvent or solvent. Thus, a diamine derivative represented by the formula (1) can be produced.

  As the base in this case, the same base as that used in the method represented by the reaction formula (1) can be used. The amount of these bases to be used is not particularly limited, and can be used as a solvent when the above organic bases are used.

  Moreover, as an organic solvent in this case, the thing similar to what is used by the method shown by Reaction formula (1) can be used.

  The usage-amount of the compound represented by Formula (9) is 1-4 equivalent with respect to the diamine derivative represented by Formula (8), Preferably it is 1-2 equivalent.

The reaction temperature and reaction time for the above reaction can be varied over a wide range. Generally, the reaction temperature is -20 to 200 ° C, preferably 0 to 100 ° C. The reaction time is 0.01 to 50 hours, preferably 0.1 to 15 hours.
The amine derivative represented by the formula (8) of the reaction formula (8) and a salt thereof can be produced by the method described in the reaction formula (9) (chemical formula 18).

[Wherein R2, R3, R4, R5, R6, R7, R8, R9, R10 and Q have the same meaning as in formula (8) (Chemical Formula 8), and A is the same as in Formula (9) (Chemical Formula 9). R1 represents a t-butyl group or an optionally substituted benzyl group. ]

  In the reaction formula (9), the diamine derivative represented by the formula (8) can be produced by reacting the diamine derivative represented by the formula (1) with an acid or hydrogenation reaction.

  As the acid in this case, hydrogen chloride, hydrogen bromide, sulfuric acid, nitric acid, acetic acid, trifluoroacetic acid and the like can be used. The amount of these acids used is not particularly limited, and can be used as a solvent.

  As the catalyst for the hydrogenation reaction, the same catalyst as that used in the method represented by the reaction formula (2) can be used.

  As the solvent used in the reaction represented by the reaction formula (9), the same solvents as those used in the method represented by the reaction formula (1) can be used.

  The reaction temperature and reaction time for the above reaction can be varied over a wide range. In general, the reaction temperature may be appropriately selected from −20 ° C. to the reflux temperature of the solvent used and the reaction time in the range of several minutes to 96 hours.

  The compound represented by the formula (9) in the reaction formula (8) can be produced by a conventional method in which the corresponding alcohol is reacted with phosgene such as phosgene and triphosgene, chloroformate such as phenyl chloroformate and the like. .

  The diamine derivative represented by the formula (1) has an asymmetric carbon depending on the type of the substituent, and may exist as an optical isomer, a diastereoisomer, a racemate, and a mixture in any ratio. All isomers of this type as well as mixtures thereof are encompassed by the present invention.

In the present invention, the bactericidal agent is a drug that kills microorganisms (pathogens) that cause pathogens such as bacteria, fungi, and viruses. Examples of such a bactericidal agent include industrial bactericides such as antiseptic and fungicidal agents, agricultural Examples include horticultural fungicides and medical / disinfecting fungicides, and the diamine derivative of the present invention exhibits a very excellent control effect particularly as an agricultural and horticultural fungicide.
The agricultural and horticultural fungicide containing the diamine derivative represented by the formula (1) which is the compound of the present invention as an active ingredient is a drug used to protect crops from attack by phytopathogenic fungi. ), Ascomycetes, Deuteromycetes, Basidiomycetes, Plasmodiophoromycetes, and other pathogens, including vegetables, fruit trees, rice, cereals, flowers, turfgrass It can be used against a wide variety of plant diseases. Next, specific disease names (bacteria names) are given as non-limiting examples. For example, rice blast (Pyricularia oryzae), sesame leaf blight (Cochliobolus miyabeanus), blight (Rhizoctonia solani), idiot seedling (Gibberella fujikuroi), seedling blight (Pythium graminicola, etc.), wheat Powdery mildew (Erysiphe graminis f.sp.hordei; f.sp.tritici), leafy leaf disease (Pyrenophora graminea), net leaf disease (Pyrenophora teres), leaf blight (Gibberella zeae), rust disease (Puccinia striiformis) ; P. graminis; P. recondita; P. hordei), snow rot (Typhula sp .; Micronectriella nivalis), naked smut (Ustilago tritici; U. nuda), eye disease (Pseudocercosporella herpotrichoides), cloud disease (Rhynchosporium) secalis), leaf blight (Septoria tritici), blight (Leptosphaeria nodorum), brown snow rot (Pythium iwayamai etc.) caused by Pythium spp.Plasmopara viticola, powdery mildew (Uncinula necator), Black mildew (Elsinoe ampelina), late rot (Glomerella cingulata), rust (Phakopsora ampelopsidis), apple powdery mildew (Podosphaera leucotricha), black spot disease (Venturia inaequalis), spotted leaf disease (Alternaria mali), red star disease (Gymnosporangium yamadae), moniliosis (Sclerotinia mali), rot (Valsa mali), pear black spot disease (Alternaria kikuchiana) , Black star disease (Venturia nashicola), red star disease (Gymnosporangium haraeanum), pear plague (Phytophthora cactorum), peach blight (Sclerotinia cinerea), black star disease (Cladosporium carpophilum), fomopsis spoilage disease (Phomopsis sp. Plague (Phytophthora sp.), Oyster anthracnose (Gloeosporium kaki), deciduous leaf (Cercospora kaki; Mycosphaerella nawae), downy mildew (Pseudoperonospora cubensis), plague (Phytophthora melonis, Phytophthorahythiathophiachthae Powdery mildew (Sphaerotheca fuliginea), Anthracnose (Colletotrichum lagenarium), Vine blight (Mycosphaerella melonis), Tomato plague (Phytophthora infestans), Seedling blight (Pythium vezans, Rhizoctonia solani), Ring crest disease (Alternaria) solani), leaf mold (Cladosporium fulvam), root rot (Pythium myriotylum, Pythium dissotocum), eggplant powdery mildew (Erysiphe cichoracoarum), plague (Phytophthora infestans), brown rot (Phytophthora capsici), cruciferous vegetables Black spot disease (Alternaria japonica), white spot disease (Cerocosporella barassicae), root-knot disease (Plasmodiophora brassicae), downy mildew (Peronospora brassicae), leek white plague (Phytophthora porri), rust disease (Puccinia allii), soybean stem Phytophthora megasperma, downy mildew (Peronospora manshurica), purpura (Cercospora kikuchii), black scab (Elsinoe glycines), black spot (Diaporthe phaseololum), common bean anthracnose (Colletotrichum lindemuthianum), peanut black astringent Diseases (Mycosphaerella personatum), brown spot (Cercospora arachidicola), pea powdery mildew (Erysiphe pisi), downy mildew (Peronospora pisi), potato plague (Phytophthora infestans), summer plague (Alternaria solan) i), Chamochi rice rot (Exobasidium reticulatum), white scab (Elsinoe leucospila), tobacco scab (Alternaria longipes), powdery mildew (Erysiphe cichoracearum), anthracnose (Colletotrichum tabacum), sugar beet brown spot (Cercospora beticola), downy mildew (Peronospora schachtii), black spot of rose (Diplocarpon rosae), downy mildew (Peronospora sparsa), plague (Phytophthora megasperma), powdery mildew (Sphaerotheca pannosa), chrysanthemum leaf spot ( Septoria chrysanthemi-indici), white rust (Puccinia horiana), plague (Phytophthora cactorum), strawberry powdery mildew (Sphaerotheca humuli), plague (Phytophthora nicotianae), fruit rot (Pythium ultimum), cucumber, tomato, strawberry, Gray mold disease (Botrytis cinerea), sclerotia disease (Sclerotinia sclerotiorum), brown patch disease (Rhizoctonia solani), dollar spot disease (Sclerotinia homoeocarpa), curbularia leaf blight (Curvularia geniculata), rust disease (Pu) ccinia zoysiae), Hermintosporium leaf blight (Cochiliobolus sp.), Cloud shape disease (Rhynchosporium secalis), Blast disease (Pyricularia oryzae), Blight (Gaeumannomyces graminis), Anthracnose (Colletotrichum graminicola), Snow rot brown Typhula incarnata, Typhula ishikariensis, Snow rot (Sclerotinia borealis), Fairy rings (Marasmius oreades, etc.), Pythium aphanidermatum, etc. Is mentioned.

  The diamine derivatives represented by the formula (1) are, in particular, grape downy mildew (Plasmopara viticola), cucurbits downy mildew (Pseudoperonospora cubensis), potato and tomato infestation fungus (Phytophthora infestans), turf pisium fungus ( Pythium aphanidermatum, etc.) and many other oomycetes have a strong bactericidal action. Plasmopara genus, Pseudoperonospora genus, Peronospora genus, Pythium genus causing various plant diseases, downy mildew, seedling Exhibits very good control effect against leaf blight and pisium disease. In addition, it has a strong bactericidal activity against rice blast fungus (Pyricularia oryzae) and exhibits an excellent control effect against rice blast.

  The active compound represented by the formula (1) has a good compatibility with the plant body at the concentration of the active compound necessary for controlling the phytopathogenic fungi, so All chemical treatments, chemical treatments for rootstocks and seeds, soil treatment, etc. are possible.

  The diamine derivative represented by the formula (1), which is the compound of the present invention, can be used in combination with other fungicides, insecticides, herbicides, plant growth regulators, and other agricultural chemicals, soil improvers or fertilizers. In addition, mixed preparations with these are also possible.

  The compounds of the present invention may be used as is, but are preferably applied in the form of a composition mixed with a carrier that includes a solid or liquid diluent. The carrier as used herein means a synthetic or natural inorganic or organic substance formulated to help the active ingredient reach the site to be treated and to facilitate the storage, transport and handling of the active ingredient compound.

  Suitable solid carriers include clays such as montmorillonite, kaolinite and bentonite, diatomaceous earth, white clay, talc, vermiculite, gypsum, calcium carbonate, silica gel, ammonium sulfate and other inorganic substances, soy flour, sawdust, wheat flour, etc. Examples include plant organic substances and urea.

  Suitable liquid carriers include aromatic hydrocarbons such as toluene, xylene and cumene, paraffinic hydrocarbons such as kerosene and mineral oil, halogenated hydrocarbons such as carbon tetrachloride, chloroform and dichloroethane, acetone and methyl ethyl ketone. Ketones, ethers such as dioxane, tetrahydrofuran and diethylene glycol dimethyl ether, alcohols such as methanol, ethanol, propanol and ethylene glycol, dimethylformamide, dimethyl sulfoxide and water.

  Furthermore, in order to enhance the efficacy of the compound of the present invention, the following adjuvants may be used alone or in combination depending on the purpose in consideration of the dosage form of the preparation, application scene, and the like.

  Adjuvants include lignin sulfonates, alkylbenzene sulfonates, alkyl sulfate esters, polyoxyalkylene alkyl sulfates and polyoxyalkylene alkyl phosphates for purposes such as emulsification, dispersion, spreading, wetting, binding and stabilization. Anionic surfactants such as ester salts, polyoxyalkylene alkyl ethers, polyoxyalkylene alkyl aryl ethers, polyoxyalkylene alkyl amines, polyoxyalkylene alkyl amides, polyoxyalkylene alkyl thioethers, polyoxyalkylene fatty acid esters, glycerin fatty acid esters, Nonionic surfactants such as sorbitan fatty acid esters, polyoxyalkylene sorbitan fatty acid esters and polyoxypropylene polyoxyethylene block polymers Calcium stearate, lubricants such as wax, stabilizers such as isopropyl hydroperoxide diene phosphate, other cellulose, carboxymethyl cellulose, casein, gum arabic, and the like. However, these components are not limited to the above.

  The amount of the active ingredient of the compound of the present invention is usually 0.5 to 20% by weight for powders, 5 to 50% by weight for emulsions, 10 to 90% by weight for wettable powders, 0.1 to 20% by weight for granules, and flowable. In the preparation, it is 10 to 90% by weight. On the other hand, the amount of carrier in each dosage form is usually 60 to 99% by weight for powders, 40 to 95% by weight for emulsions, 10 to 90% by weight for wettable powders, 80 to 99% by weight for granules, and for flowable formulations. 10 to 90% by weight. The amount of the adjuvant is usually 0.1 to 20% by weight for powders, 1 to 20% by weight for emulsions, 0.1 to 20% by weight for wettable powders, 0.1 to 20% by weight for granules, and flowable. In the preparation, it is 0.1 to 20% by weight.

  In order to obtain an additive or synergistic effect on the control of a wide variety of pests occurring in the fields of vegetables, fruit trees, rice, cereals, flowers, turfgrass, the compounds of the present invention and other fungicides and / or insecticides One or more of these may be used in combination.

  Fungicides that can be used in combination with the compounds of the present invention include triazimephone, hexaconazole, propiconazole, ipconazole, prochloraz, triflumizole, tebuconazole, epoxiconazole, difenoconazole, flusilazole, triadimenol, cyproconazole, metconazole , Fluquinconazole, viteltanol, tetraconazole, triticonazole, flutriafor, penconazole, diniconazole, fenbuconazole, bromconazole, imibenconazole, cimeconazole, microconazole, microbutanyl, himexazole, imazalyl, framtopir, tifluzamide , Etridiazole, oxyspoconazole, oxyspoconazole fumarate, pefazoate, prothioconazo Azole fungicides such as rupi, pyrimidine fungicides such as pyriphenox, phenarimol, nuarimol, buprimate, anilinopyrimidine fungicides such as mepanipyrim, cyprodinyl, pyrimethanil, acylalanine fungicides such as metalaxyl, oxadixil, benalaxyl Benzimidazole fungicides such as thiophanate methyl, thiophanate methyl, benomyl, carbendazim, fuberidazole, thiabendazole, dithiocarbamate fungicides such as manzeb, propineb, dinebu, methylam, manneb, dilam, thiuram, and organics such as tetrachloroisophthalonitrile Chlorine fungicides, ethaboxam, oxycarboxin, carboxin, flutolanil, silthiophane, carboxamide fungicides such as mepronil, dimethomorph, fe Morpholine fungicides such as propidin, phenpropimorph, spiroxamine, tridemorph, dodemorph, and furmorph, azoxystrobin, cresoxime methyl, methinostrobin, orisatrobin, fluoxastrobin, trifloxystrobin, dimoxystrobin, pyraclosto Stobilurin fungicides such as robin and picoxystrobin, dicarboximide fungicides such as iprodione, procymidone, vinclozolin and crozolinate, fursulfamide, dazomet, methylisothiocyanate, chloropicrin, metasulfocarb, hydroxyisoxazole, hydroxyiso Soil fungicides such as potassium xoxazole, echromesole, DD, carb, basic copper chloride, basic copper sulfate, copper nonylphenol sulfonate, o Copper fungicides such as xin copper, DBEDC, anhydrous copper sulfate, copper sulfate pentahydrate, cupric hydroxide, inorganic sulfur, hydrated sulfur agent, lime sulfur mixture, zinc sulfate, fentine, sodium hydrogen carbonate, hydrogen carbonate Inorganic fungicides such as potassium, hypochlorite and metallic silver, organophosphorus fungicides such as edifenphos, tolcrofosmethyl, fosetyl, iprobenphos, dinocap, pyrazophos, carpropamide, fusalide, tricyclazole, pyroxylone, diclocimet, phenoxanil, etc. Melanin biosynthesis inhibitor fungicides, kasugamycin, validamycin, polyoxins, blasticidin S, teclophthalam, oxytetracycline, mildiomycin, streptomycin and other antibiotic fungicides, rapeseed oil and other natural products fungicides, Bench Abari Carb isopropyl, ipro Carbamate fungicides such as recarb, propamocarb, and dietofencarb, pyrrole fungicides such as fluorimide, fludioxanyl, and fenpiclonil, plant activators that induce plant disease resistance such as probenazole, acibenzoral S methyl, and thiazinyl, ciflufenamide, phenhexamide , Quinoxyphene, Diflumetrim, Metraphenone, Picobenzamide, Proquinazide, Famoxadone, Ciazofamide, Phenamidone, Zoxamide, Boscalid, Chlorothalonyl, Simoxanyl, Captan, Dithianon, Fluazinam, Forpet, Diclofluanid, Triphorine, Oxolinicimine, Isoprothiolane , Quinomethionate, iminotadine acetate, imi Kutadine albesylate, ambam, polycarbamate, thiadiazine, chloroneb, organonickel, guazatine, dodine, quintozene, tolylfluanid, anilazine, nitrotalisopropyl, fenitropan, dichlorane, DPC, dimethylirimol, benzazole, flumethover, mandy Examples include fungicides such as propamide.

  (RS) -N- [2- (1,3-dimethylbutyl) thiophen-3-yl] -1-methyl-3-trifluoromethyl-1H-pyrazole-4 as a compound that can be used in combination with the compound of the present invention -Carboxamide (generic name pending: penthiopyrad). This compound is described in Japanese Patent No. 3164762, which describes the bactericidal activity as well as the production method.

  As a compound that can be used in combination with the compound of the present invention, the compound of formula (10)

The compound represented by these is mentioned. This compound is described in WO 01/10825 pamphlet (2001), and the bactericidal activity and production method are described.

  As a compound that can be used in combination with the compound of the present invention, the compound of formula (11)

The compound represented by these is mentioned. This compound is described in US Pat. No. 6,620,812, which describes the bactericidal activity as well as the production process.

  Insecticides that can be used in combination with the compounds of the present invention include allethrin, tetramethrin, resmethrin, phenothrin, furamethrin, permethrin, cypermethrin, deltamethrin, cyhalothrin, cyfluthrin, phenpropatoline, tralomethrin, cycloprotorin, flucitrinate, fluvinate , Synthetic pyrethroid insecticides such as, acrinatrin, tefluthrin, bifenthrin, enpentrin, beta cyfluthrin, cypermethrin, fenvalerate, esfenvalerate, flubrocitrinate, metflufluthrin, profluthrin, dimethylfluthrin, and various isomers or pesticide extracts DDVP, cyanophos, phenthion, fenitrothion, tetrachlorbinphos, dimethylvinphos, propa , Methyl parathion, temefos, phoxime, acephate, isofenphos, salicione, DEP, EPN, ethion, mecarbam, pyridafenthion, diazinon, pyrimiphosmethyl, etrimphos, isoxathione, quinalphos, chlorpyrifosmethyl, chlorpyrifos, hosalon, phosmet, methidathion thiode, , Phentoate, dimethoate, formotethione, thiomethone, ethylthiomethone, folate, terbufos, profenofos, prothiophos, sulfrophos, pyracrofos, monocrotophos, naredo, phostiazete, trichlorfone, etoprofos, kazusafos, chlorfenvinphos, diclofenthion, methophoste tebrothone Muphos, ometoate, triazophos, oxydemeton-methyl, azinephos-methyl, chloroethoxyphos, dicrotophos, disulfotone, fanamiphos, phosphamidone, trichlorphone, chlormefos, demeton-S-methyl, mebinphos, parathion, tebuprimfos and other organic phosphorus insecticides, NAC , MTMC, MIPC, BPMC, XMC, PHC, MPMC, etiophen carb, bendiocarb, pirimicarb, carbosulfan, benfracarb, mesomil, oxamyl, aldicarb, thiodicarb, alanib, carbofuran, methiocarb, phenothiocarb, formethanate, xylyl methyl carbamate Carbamate insecticides such as propoxal and isoprocarb, etofenprox, halfenpro Arylpropyl ether insecticides such as ox, silyl ether compounds such as silafluophene, nicotine sulfate, polynactin complex, abamectin, milbemectin, lepimectin, BT agent and other insecticidal natural products, cartap, thiocyclam, benzl-tap, diflubenzuron, chlorflu Azuron, teflubenzuron, triflumuron, flufenoxuron, flucycloxuron, hexaflumuuron, fluazuron, imidacloprid, nitenpyram, acetamiprid, dinotefuran, thiamethoxam, thiacloprid, clothianidin, pymetrozine, fipronil, buprofezin, phenoxycarburine, phenoxycarb , Hydroprene, quinoprene, endosulfan, diafenthiuron, triazuron, tebufu Nozide, benzoepin, nobarulone, nobiflumuron, emamectin, emamectin benzoate, clothianidin, thiacloprid, thiamethoxam, flupirazophos, acequinosyl, bifenazate, chromafenozide, etoxazole, fluacrylpyrim, flufenzine, halofenodiphen, cloxanododo , Ethiprole, acetoprole, amidoflumet, bistrifluron, flonicamid, fulbrocis linate, flufenerim, pyridalyl, spinosad, spiromesifen, silafluophene, cyromazine, lufenuron, esfenvalerate, sodium oleate, potassium oleate, chlorfenapyr, Kelsen, Aza Ilactin, carbam, carbam sodium, propargite, fenbutatin oxide, bromopropyrate, azocyclotin, benzoxymate, chinomethionate, chlorophenapyl, metaldehyde, triazamate, endosulfan, lindane, prototriphen boot, aminoflumate , Insecticides such as Benclothiaz, difluvidazine, fulvendiamide, and metaflumizole.

  Acaricides such as dicophore, chlorbenzilate, phenisobromolate, tetradiphone, CPCBS, BPPS, quinomethionate, amitraz, benzomate, hexithazox, fenbutazin oxide, cyhexatin, dienochlor, clofentedine, pyridaben, fenpyroximate, phenazaquin, tebufenpyrad, pyrimidifen Is mentioned.

  As a compound that can be used in combination with the compound of the present invention, the compound of formula (12)

 [Wherein R8 represents a methyl group or a chloro group, R9 represents a methyl group, a chloro group, a bromo group or a cyano group, R10 represents a chloro group, a bromo group, a trifluoromethyl group or a cyanomethoxy group; Represents a methyl group or an isopropyl group. The compound represented by this is mentioned. This compound is described in International Publication No. 03/315519 pamphlet (2003), and describes the insecticidal activity and the production method.

  As a compound that can be used in combination with the compound of the present invention, the compound of formula (13)

 [Wherein R12 represents a 1,1,1,2,3,3,3-heptafluoro-2-propyl group or a 1,1,2,2,3,3,3-heptafluoro-1-propyl group. To express. The compound represented by this is mentioned. This compound is described in JP-A-2001-342186, and describes insecticidal activity and production method.

  When the compound of the present invention is used in combination with one or more other fungicides and / or insecticides, it may be used as a mixed composition of the compound of the present invention and other fungicides and / or insecticides, Alternatively, the compound of the present invention and other fungicides and / or insecticides may be mixed and used at the time of agrochemical treatment.

  In the following, this description will be described in more detail with reference to examples and test examples.

N- [2-phenyl-1- (S)-[(benzofuran-2-carbonyl) aminomethyl] ethyl] [3-methyl-2- (S)-(1-methylethyloxycarbonyl) amino] butyric acid amide ( Compound No. 44)
To a THF solution (3 ml) of 2- (S)-[(1-methylethyloxycarbonyl) amino] acetic acid (0.24 g, 1.49 mmol), 1,1′-carbonylbis-1H-imidazole (0.25 g, 1.54 mmol) was added at room temperature and stirred for 1 hour. N- (2- (S) -amino-3-phenylpropyl) benzofuran-2-carboxylic acid amide hydrochloride (0.40 g, 1.21 mmol) and imidazole (0.25 g, 3.67 mmol) were added to the reaction solution at room temperature. And stirred at room temperature for 12 hours. The reaction mixture was washed successively with 5% aqueous citric acid solution, saturated brine, saturated aqueous sodium hydrogen carbonate solution and saturated brine, and dried over anhydrous magnesium sulfate. After filtering the inorganic salt, the residue obtained by concentration under reduced pressure was purified by silica gel column chromatography (n-hexane: ethyl acetate = 1: 1) to obtain 0.49 g of the desired product as a white solid ( Yield 85%).

N- [2-Cyclopropyl-1- (S)-[(4-methylbenzoyl) aminomethyl] ethyl] [3-methyl-2- (S)-[(2-methylpropyloxycarbonyl) amino] butyric acid amide (Compound No. 4)
3-Methyl-2- (S)-[(2-methylpropyloxycarbonyl) amino] butyric acid (1.19 g, 5.87 mmol), N- [2- (S) -amino-3- (cyclopropyl) propyl ] A solution of 4-methylbenzoic acid amide hydrochloride (1.31 g, 4.89 mmol), N-hydroxysuccinimide (0.64 g, 6.36 mmol), dicyclohexylcarbodiimide (1.30 g, 6.36 mmol) in dichloromethane ( 50 ml), triethylamine (0.59 g, 5.87 mmol) was added at room temperature, and the mixture was stirred at room temperature for 5 hours. The formed dicyclohexylurea crystals were removed by filtration, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (n-hexane: ethyl acetate = 1: 1) to obtain 1.37 g of the desired product as a white solid (yield 65%).

N-[[2-([(Benzofuran-2-carbonyl) amino] -1-S) -phenylethyl] [2- (S)-[(1-ethoxycarbonyl) amino] -3-methyl] butyric acid amide ( Compound No. 37)
To a solution of 3-methyl-2- (S)-[(2-ethoxycarbonyl) amino] butyric acid (0.46 g, 2.42 mmol) in dichloromethane (10 ml) at −15 ° C. was added N-methylmorpholine (0.27 ml, 2.42 mmol) was added. 2-Methylpropyloxycarbonyl chloride (0.33 ml, 2.58 mmol) was added dropwise, and the mixture was stirred at −15 ° C. for 5 minutes. A dichloromethane solution (5 ml) of N- [2- (S) -amino-2-phenylethyl] benzofuran-2-carboxamide (0.47 g, 1.61 mmol) was added to the reaction solution at −15 ° C., and the mixture was stirred for 20 minutes. . The reaction mixture was concentrated under reduced pressure, the residue was dissolved in ethyl acetate (20 ml), washed successively with water, 5% aqueous citric acid solution, saturated aqueous sodium hydrogen carbonate solution and saturated brine, and dried over anhydrous sodium sulfate. After filtering the inorganic salt, the crude product obtained by concentration under reduced pressure was washed with diisopropyl ether to obtain 0.90 g of the desired product as a white solid (yield 82%).

N- [2-phenyl-1- (S)-[(4-methylbenzoyl) aminomethyl] ethyl] [3-methyl-2- (S)-[(1-methylethyloxycarbonyl) amino] butyric acid amide ( Compound No. 13)
N- [2-Phenyl-1- (S)-[(4-methylbenzoyl) aminomethyl] ethyl] [2- (S) -amino-3-methyl] butyric acid amide (0.85 g, 2.32 mmol), 1-Methylethyloxycarbonyl chloride (0.31 g, 2.55 mmol) was added to a dichloromethane solution (50 ml) of triethylamine (0.26 g, 2.55 mmol) under ice cooling, and the mixture was stirred at room temperature for 2 hours. The reaction mixture was washed successively with 5% aqueous citric acid solution, saturated brine, 2N aqueous sodium hydroxide solution and saturated brine, and dried over anhydrous magnesium sulfate. After filtering the inorganic salt, the crude product obtained by concentration under reduced pressure was washed with diisopropyl ether to obtain 0.94 g of the desired product as white crystals (yield 89%).

N- [2-Phenyl-1- (S)-[(5-bromofuran-2-yl) aminomethyl] ethyl] [3-methyl-2- (S)-(1-methylethyloxycarbonyl) amino] butyric acid Amide (Compound No. 83)
To a THF solution (3 ml) of 5-bromofuran-2-carboxylic acid (0.28 g, 1.49 mmol) was added 1,1′-carbonylbis-1H-imidazole (0.25 g, 1.54 mmol) at room temperature. Stir for hours. N- [2-Phenyl-1- (S)-(aminomethyl) ethyl] [3-methyl-2- (S)-(1-methylethyloxycarbonyl) amino] butyric acid amide (0.41 g , 1.21 mmol) at room temperature and stirred for 12 hours at room temperature. The reaction mixture was washed successively with 5% aqueous citric acid solution, saturated brine, saturated aqueous sodium hydrogen carbonate solution and saturated brine, and dried over anhydrous magnesium sulfate. After filtering the inorganic salt, the residue obtained by concentration under reduced pressure was purified by silica gel column chromatography (n-hexane: ethyl acetate = 1: 1) to obtain 0.52 g of the desired product as a white solid ( Yield 85%).

  The production method of the intermediate is shown below as a reference example.

[Reference Example 1]
N- [1- (S)-(Aminomethyl) -2-phenylethyl] carbamic acid 1,1-dimethylethyl ester N- [1- (S)-(hydroxymethyl) -2-phenylethyl] carbamic acid 1 , 1-dimethylethyl ester (30.91 g, 122.98 mmol) in tetrahydrofuran (250 ml) was added phthalimide (18.10 g, 123.02 mmol) and triphenylphosphine (35.50 g, 135.35 mmol), and ice-cooled. Under stirring, a tetrahydrofuran solution (10 ml) of azodicarboxylic acid diethyl ester (23.60 g, 135.51 mmol) was added dropwise, and the mixture was stirred for 1 hour under ice-cooling and further for 4 hours at room temperature. The solvent was concentrated under reduced pressure and dried. The white solid of the obtained N- [2- (S)-[(1,1-dimethylethyloxycarbonyl) amino] -3-phenylpropyl] phthalimide was added to ethanol (500 ml) and hydrazine monohydrate (13.1 g). , 261.69 mmol) and refluxed at 100 ° C. for 2 hours. The precipitated white crystals of phthaloyl hydrazide were removed by filtration, and the reaction solution was allowed to stand overnight. Further, the precipitated phthaloyl hydrazide was removed by filtration. The solvent was concentrated under reduced pressure and then dried. Dichloromethane (500 ml) was added to the residue and washed with 2N aqueous sodium hydroxide solution (500 ml). The organic layer was extracted with 5% aqueous citric acid solution (500 ml), and the aqueous layer was washed with dichloromethane (500 ml). The aqueous layer was adjusted to pH 12 with sodium hydroxide (10.40 g), extracted with dichloromethane (500 ml), washed with 2N aqueous sodium hydroxide solution (500 ml), and dried over anhydrous sodium sulfate. The inorganic salt was filtered and concentrated under reduced pressure to obtain 27.09 g of the desired product as a white solid (yield 88%).

[Reference Example 2]
N- [3-Phenyl-2- (S)-[(1,1-dimethylethyloxycarbonyl) amino] propyl] Benzofuran-2-carboxylic acid amide Benzofuran-2-carboxylic acid (15.0 g, 92.5 mmol) 1,1′-carbonylbis-1H-imidazole (15.8 g, 97.6 mmol) was added to a dichloromethane solution (300 ml) at room temperature and stirred for 2 hours. N- [1- (S)-(aminomethyl) -2-phenylethyl] carbamic acid 1,1-dimethylethyl ester (23.16 g, 92.5 mmol) was added to the above reaction solution, and the mixture was stirred overnight for 5 hours. I left it alone. The reaction mixture was washed successively with 5% aqueous citric acid solution, water, saturated aqueous sodium hydrogen carbonate solution and water, and the organic layer was dried over anhydrous sodium sulfate. After the inorganic salt was filtered off, the crude product obtained by concentration under reduced pressure was recrystallized using diisopropyl ether to obtain 31.02 g of the desired product as a white solid (yield 85%).

[Reference Example 3]
N- [3-Phenyl-2- (S) -aminopropyl] Benzofuran-2-carboxylic acid amide hydrochloride N- [3-Phenyl-2- (S)-[(1,1-dimethylethyloxycarbonyl) amino ] Propyl] Benzofuran-2-carboxylic acid amide (30.57 g, 77.5 mmol) was dissolved in ethyl acetate (50 ml), 4N hydrogen chloride / ethyl acetate solution (200 ml) was added, and the mixture was stirred at room temperature for 6 hours. The precipitated salt was washed with ethyl acetate, collected by filtration and dried to obtain 24.61 g of the desired product as a white solid (yield 96%).

The compounds represented by formula (1) that can be produced in the same manner as in Examples 1 to 5 are shown in Table 1. In addition, some of the physical property values are shown in Table 2. In Table 1, Me is a methyl group, Et is an ethyl group, iPr is an isopropyl group, iBu is an isobutyl group, sBu is a secondary butyl group, tBu is a tertiary butyl group, and cPr- CH2 is a cyclopropylmethyl group, a cHex-CH ₂ cyclohexyl methyl group, a Ph is phenyl, Bn is a benzyl group, cHex is cyclohexyl, vinyl is an ethenyl group, propargyl is a 2-propynyl group, 3-THF represents a tetrahydrofuran-3-yl group.

  The diamine derivative represented by the formula (1) has an asymmetric carbon depending on the type of the substituent, and may exist as an optical isomer, a diastereoisomer, a racemate, and a mixture in any ratio.

[Formulation examples and test examples]
Next, formulation examples and bactericidal activity test examples of the bactericide according to the present invention are shown. In the following description, “parts” means “parts by weight” or “% by weight”.

Formulation example 1 (powder)
2 parts of Compound No. 3 and 98 parts of clay were mixed and ground uniformly to obtain a powder containing 2% of active ingredient.

Formulation Example 2 (wettable powder)
10 parts of the compound of Compound No. 4, 70 parts of kaolin, 18 parts of white carbon and 2 parts of calcium alkylbenzenesulfonate are uniformly mixed and pulverized to obtain a wettable powder containing 10% of active ingredient in the form of fine powder of uniform composition. It was.

Formulation Example 3 (wettable powder)
Compound No. 8 (20 parts), alkylbenzenesulfonate calcium (3 parts), polyoxyethylene nonylphenyl ether (5 parts) and clay (72 parts) were uniformly mixed and pulverized to contain 20% of active ingredient in the form of fine powder of uniform composition. A wettable powder was obtained.

Formulation Example 4 (wettable powder)
50 parts of the compound of Compound No. 9, 1 part of sodium lignin sulfonate, 5 parts of white carbon and 44 parts of diatomaceous earth were mixed and ground to obtain a wettable powder containing 50% of the active ingredient.

Formulation Example 5 (Flowable)
A flowable agent containing 5% of an active ingredient by wet-grinding 5 parts of Compound No. 10, 7 parts of propylene glycol, 4 parts of sodium lignin sulfonate, 2 parts of dioctyl sulfosuccinate sodium salt, and 82 parts of water with a sand grinder Obtained.

Formulation Example 6 (Flowable)
A flowable agent containing 10 parts of the active ingredient, 10 parts of the compound No. 13, 7 parts of propylene glycol, 2 parts of sodium lignin sulfonate, 2 parts of dioctyl sulfosuccinate sodium salt, and 79 parts of water wet-ground with a sand grinder. Got.

Formulation Example 7 (Flowable)
Sand of 25 parts of Compound No. 19, 5 parts of propylene glycol, 5 parts of polyoxyethylene oleate, 5 parts of polyoxyethylene diallyl ether sulfate, 0.2 part of silicone antifoaming agent, and 59.8 parts of water The powder was wet pulverized with a grinder to obtain a flowable agent having an active ingredient of 25%.

Formulation Example 8 (powder)
Compound 3 of Compound No. 20, 2 parts of fusalide, 20 parts of diatomaceous earth, 30 parts of white clay and 45 parts of talc were uniformly ground and mixed to obtain 100 parts of a powder.

Formulation Example 9 (wettable powder)
10 parts of the compound of Compound No. 21, 20 parts of ferrimzone, 1 part of sodium lignin sulfonate, 2 parts of sodium alkylbenzene sulfonate and 67 parts of diatomaceous earth were uniformly ground and mixed to obtain 100 parts of a wettable powder.

Formulation Example 10 (wettable powder)
Compound 10 of Compound No. 24, 50 parts of Manzeb, 5 parts of sodium lignin sulfonate, 5 parts of sodium alkylnaphthalene sulfonate, 5 parts of white carbon and 25 parts of diatomaceous earth are uniformly ground and mixed to obtain 100 parts of wettable powder. It was.

Formulation Example 11 (wettable powder)
Compound 10 of Compound No. 25, 50 parts of chlorothalonil, 5 parts of sodium lignin sulfonate, 5 parts of sodium alkylnaphthalene sulfonate, 5 parts of white carbon and 25 parts of diatomaceous earth are uniformly ground and mixed to obtain 100 parts of wettable powder. It was.

Formulation Example 12 (wettable powder)
Compound 10 of Compound No. 26, 40 parts of phorpet, 5 parts of sodium lignin sulfonate, 5 parts of sodium alkylnaphthalene sulfonate, 5 parts of white carbon and 35 parts of diatomaceous earth are uniformly ground and mixed, and 100 parts of wettable powder are added. Obtained.

Formulation Example 13 (Flowable)
10 parts of Compound No. 42, 10 parts of Simoxanyl, 3 parts of carboxymethyl cellulose, 2 parts of sodium lignin sulfonate, 1 part of dioctyl sulfosuccinate sodium salt and 74 parts of water were wet-ground with a sand grinder to obtain 100 parts of a flowable agent. It was.

Formulation Example 14 (Flowable)
Compound No. 43 (10 parts), metalaxyl (10 parts), carboxymethyl cellulose (3 parts), lignin sodium sulfonate (2 parts), dioctyl sulfosuccinate sodium salt (1 part) and water (74 parts) were wet crushed with a sand grinder to obtain 100 parts of a flowable agent. It was.

Formulation Example 15 (Flowable)
Compound No. 44 compound 10 parts, dimethomorph 10 parts, carboxymethyl cellulose 3 parts, lignin sulfonate 2 parts, dioctyl sulfosuccinate sodium salt 1 part and water 74 parts wet milled with a sand grinder to obtain 100 parts flowable agent It was.

Formulation Example 16 (Emulsion)
10 parts of Compound No. 46, 10 parts of imidacloprid, 10 parts of cyclohexane, 50 parts of xylene and 20 parts of Solpol (Toho Chemicals Surfactant) were uniformly dissolved and mixed to obtain 100 parts of an emulsion.

Formulation Example 17 (powder)
2 parts of compound No. 82 and 98 parts of clay were uniformly mixed and ground to obtain a powder containing 2% of active ingredient.

Formulation Example 18 (wettable powder)
Compound No. 83 (10 parts), kaolin (70 parts), white carbon (18 parts) and alkylbenzenesulfonate calcium (2 parts) were uniformly mixed and pulverized to obtain a wettable powder containing 10% active ingredient in the form of fine powder of uniform composition. It was.

Formulation Example 19 (wettable powder)
Compound No. 3 (20 parts), alkylbenzenesulfonate calcium (3 parts), polyoxyethylene nonylphenyl ether (5 parts) and clay (72 parts) were uniformly mixed and pulverized, and contained 20% active ingredient in the form of fine powder of uniform composition. A wettable powder was obtained.

Formulation Example 20 (wettable powder)
50 parts of the compound of Compound No. 4, 1 part of sodium lignin sulfonate, 5 parts of white carbon and 44 parts of diatomaceous earth were mixed and ground to obtain a wettable powder containing 50% of the active ingredient.

Formulation Example 21 (Flowable)
A flowable agent containing 5% of an active ingredient by wet-grinding 5 parts of a compound of Compound No. 8, 7 parts of propylene glycol, 4 parts of sodium lignin sulfonate, 2 parts of dioctyl sulfosuccinate sodium salt, and 82 parts of water with a sand grinder. Obtained.

Formulation Example 22 (Flowable)
A flowable agent containing 10 parts of an active ingredient by wet-grinding 10 parts of the compound No. 9 compound, 7 parts of propylene glycol, 2 parts of sodium lignin sulfonate, 2 parts of dioctyl sulfosuccinate sodium salt and 79 parts of water with a sand grinder Got.

Formulation Example 23 (Flowable)
Sand for 25 parts of Compound No. 10, 5 parts of propylene glycol, 5 parts of polyoxyethylene oleate, 5 parts of polyoxyethylene diallyl ether sulfate, 0.2 part of silicon-based antifoaming agent, and 59.8 parts of water The powder was wet pulverized with a grinder to obtain a flowable agent having an active ingredient of 25%.

Formulation Example 24 (powder)
3 parts of the compound of Compound No. 13, 2 parts of fusalide, 20 parts of diatomaceous earth, 30 parts of white clay and 45 parts of talc were uniformly ground and mixed to obtain 100 parts of a powder.

Formulation Example 25 (wettable powder)
10 parts of the compound of Compound No. 19, 20 parts of ferrimzone, 1 part of sodium lignin sulfonate, 2 parts of sodium alkylbenzene sulfonate and 67 parts of diatomaceous earth were uniformly ground and mixed to obtain 100 parts of a wettable powder.

Formulation Example 26 (wettable powder)
Compound No. 20 (10 parts), Manzeb (50 parts), lignin sulfonate (5 parts), alkyl naphthalene sulfonate (5 parts), white carbon (5 parts) and diatomaceous earth (25 parts) were uniformly ground and mixed to obtain 100 parts of wettable powder. It was.

Formulation Example 27 (wettable powder)
Compound 10 of Compound No. 21, 50 parts of chlorothalonil, 5 parts of sodium lignin sulfonate, 5 parts of sodium alkylnaphthalene sulfonate, 5 parts of white carbon and 25 parts of diatomaceous earth are uniformly ground and mixed to obtain 100 parts of wettable powder. It was.

Formulation Example 28 (wettable powder)
Compound 10 of Compound No. 24, 40 parts of phorpet, 5 parts of sodium lignin sulfonate, 5 parts of sodium alkylnaphthalene sulfonate, 5 parts of white carbon and 35 parts of diatomaceous earth are uniformly ground and mixed, and 100 parts of wettable powder are added. Obtained.

Formulation Example 29 (Flowable)
10 parts of Compound No. 25, 10 parts of Simoxanyl, 3 parts of carboxymethyl cellulose, 2 parts of sodium lignin sulfonate, 1 part of dioctyl sulfosuccinate sodium salt and 74 parts of water were wet-ground with a sand grinder to obtain 100 parts of a flowable agent. It was.

Formulation Example 30 (Flowable)
10 parts of Compound No. 26, 10 parts of metalaxyl, 3 parts of carboxymethyl cellulose, 2 parts of sodium lignin sulfonate, 1 part of dioctyl sulfosuccinate sodium salt and 74 parts of water are wet-ground with a sand grinder to obtain 100 parts of a flowable agent. It was.

Formulation Example 31 (Flowable)
10 parts of Compound No. 37, 10 parts dimethomorph, 3 parts carboxymethylcellulose, 2 parts sodium lignin sulfonate, 1 part dioctylsulfosuccinate sodium salt and 74 parts water are wet-ground with a sand grinder to obtain 100 parts of a flowable agent. It was.

Formulation Example 32 (Emulsion)
10 parts of Compound No. 38, 10 parts of imidacloprid, 10 parts of cyclohexane, 50 parts of xylene and 20 parts of Solpol (Toho Chemicals Surfactant) were uniformly dissolved and mixed to obtain 100 parts of an emulsion.

Next, the effect of the fungicide of the present invention will be specifically described with reference to test examples. The comparative drug used was a compound described as an agricultural and horticultural fungicide in the specification of WO 03008372, and was prepared in the same manner as the test compound.
Comparative compound

Test Example 1 Control effect against tomato plague 1 Tomato seedlings (variety: the world's best, one in a 7.5 cm diameter plastic pot) in which the compound dissolved in acetone is diluted with water to 250 ppm and four leaves are developed 10 mL was sprayed per pot. After air drying, it was transferred to a wet chamber (12 hours light-dark cycle) at 18 ° C. and sprayed with a zoospore suspension of Phytophthora infestans. Four days after the inoculation, the diseased area ratio of four leaflets was investigated and evaluated according to the following criteria.
The disease area ratio in the untreated area at the time of the survey was 60% or more.

A: Disease area rate less than 5% B: Disease area rate 5% to less than 50% C: Disease area rate 50% or more

Test Example 2 Control effect against cucumber downy mildew A compound dissolved in acetone was diluted with water to 250 ppm, and the first leaf of the cucumber was developed (variety: Sagami Hanjiro, 7.5 cm in diameter in a vinyl pot) 10 mL per one pot was sprayed on 2 stands). After air-drying, it was transferred to a moist chamber installed in a greenhouse, and sprayed with a zoosporangium suspension of Pseudoperonospora cubensis. Seven days after the inoculation, the disease area ratio of the true leaves was investigated and evaluated according to the following criteria. The disease area ratio in the untreated area at the time of the survey was 60 to 80%.

A: Disease area rate less than 5% B: Disease area rate 5% to less than 50% C: Disease area rate 50% or more

Test Example 3 Control Effect on Grape Mildew A developed leaf of a grape seedling (variety: Cabernet Sauvignon) grown in a 1 / 2000a pot was cut out to produce a leaf disk having a diameter of 32 mm. The compound dissolved in acetone was diluted with water to 250 ppm, and the leaf disk was immersed for 3 hours. After taking out from the drug solution and air-drying, spray inoculated with a zoosporangium suspension of Plasmopara viticola. The cells were cultured at 18 ° C. for 12 hours in a light / dark light cycle, and the diseased area ratio of leaf discs was examined 10 days after inoculation and evaluated according to the following criteria. The disease area ratio in the untreated area at the time of the survey was 60 to 70%.

A: Disease area rate less than 5% B: Disease area rate 5% to less than 50% C: Disease area rate 50% or more

Test Example 4 Control Effect on Rice Blast Disease 1 A compound dissolved in acetone was diluted with water to a concentration of 250 ppm, and the 4th leaf was developed (variety: Tsukimi Mochi, 50 plants in a 6 cm diameter vinyl pot). 10 mL was sprayed per pot. After air drying, the cells were transferred to a moist chamber (25 hours light / dark light cycle) at 25 ° C. and sprayed with a rice blast fungus (Pyricularia oryzae) conidial spore suspension. Seven to ten days after the inoculation, the number of lesions in the entire pot was examined and evaluated according to the following criteria. The number of lesions per pot in the untreated section at the time of the survey was 60 or more.

A: Less than 5 lesions
B: Number of lesions 6 to less than 50
C: More than 50 lesions

Test Example 5 Inhibition of Mycelial Elongation against Psium Species After a potato dextrose agar medium (hereinafter referred to as PDA) was cooled to 40 ° C., a compound dissolved in acetone was added to 100 ppm, and 15 mL was poured into a 9 cm diameter petri dish to cool. . The hyphal tip of Pythium aphanidermatum previously grown on PDA was punched out with a 6 mm diameter cork borer and transplanted to a drug-containing PDA with the flora facing down. After culturing in a dark place at 25 ° C. for 24 hours, the hyphal elongation diameter was measured and evaluated according to the following criteria.

A: Inhibition rate for the no-drug group 95% or more B: Inhibition rate for the no-drug group 50 to less than 95% C: Inhibition rate for the no-drug group less than 50%

Claims (13)

Formula (1 )

[In the formula, R1 is an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, a cycloalkenyl group having 3 to 6 carbon atoms, or a group having 2 to 6 carbon atoms. An alkynyl group, an aryl group, a heterocyclic ring, an arylalkyl group having 1 to 6 carbon atoms in the alkyl group, or a heterocyclic alkyl group having 1 to 6 carbon atoms in the alkyl group; R2 and R5 are each independently hydrogen; Atom, alkyl group having 1 to 6 carbon atoms, cycloalkyl group having 3 to 6 carbon atoms, alkenyl group having 2 to 6 carbon atoms, cycloalkenyl group having 3 to 6 carbon atoms, alkynyl group having 2 to 6 carbon atoms, acyl A group, an aryl group, a heterocycle, an arylalkyl group having 1 to 6 carbon atoms in the alkyl group, or a heterocyclic alkyl group having 1 to 6 carbon atoms in the alkyl group, and R3 and R4 are each independently a hydrogen atom. , Carbon number 1 Alkyl group, cycloalkyl group having 3 to 6 carbon atoms, alkenyl group having 2 to 6 carbon atoms, cycloalkenyl group having 3 to 6 carbon atoms, alkynyl group having 2 to 6 carbon atoms, aryl group, heterocycle, alkyl group Represents an arylalkyl group having 1 to 6 carbon atoms, or a heterocyclic alkyl group having 1 to 6 carbon atoms, or R3 and R4 are bonded to each other to form a hydrocarbon ring having 3 to 6 carbon atoms. R6, R7, R8 and R9 may each independently form a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, A C3-C6 cycloalkenyl group, a C2-C6 alkynyl group, an aryl group, a heterocycle, an alkyl group having 1-6 carbon atoms, or an alkyl group having 1-6 carbon atoms Heterocycle A Represents a kill group, provided that at least one of R6, R7, R8 and R9 is an aryl group, a heterocycle, an arylalkyl group having 1 to 6 carbon atoms in an alkyl group, or an alkyl group having 1 to 6 carbon atoms. Represents a heterocyclic alkyl group, or a pair of R6 and R7 or R8 and R9 may be bonded to each other to form a hydrocarbon ring having 3 to 6 carbon atoms, and R10 represents a hydrogen atom, 6 represents an alkyl group, a cycloalkyl group having 3 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, a cycloalkenyl group having 3 to 6 carbon atoms, an alkynyl group having 2 to 6 carbon atoms, an acyl group, Represents an oxygen atom or a sulfur atom, and Q represents an aryl group or a heterocyclic ring. ] The diamine derivative represented by this. At least one of R3 and R4 is an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, a cycloalkenyl group having 3 to 6 carbon atoms, or 2 to 2 carbon atoms. 6 alkynyl group, aryl group or heterocycle, arylalkyl group having 1 to 6 carbon atoms in the alkyl group, or heterocyclic alkyl group having 1 to 6 carbon atoms in the alkyl group, or R3 and R4 are The diamine derivative according to claim 1, which may be bonded to form a hydrocarbon ring having 3 to 6 carbon atoms. The diamine derivative according to claim 2, wherein R10 is a hydrogen atom. The diamine derivative according to claim 3, wherein R2 and R5 are hydrogen atoms. A fungicide containing the diamine derivative according to any one of claims 1 to 4 as an active ingredient. An agricultural and horticultural fungicide containing the diamine derivative according to any one of claims 1 to 4 as an active ingredient. Formula (2 )

[Wherein, R 1, R 2, R 3, R 4, R 5, R 6, R 7, R 8, R 9, R 10 and A represent the same meaning as in claim 1. The compound represented by the formula (3 )

[Wherein Q represents the same meaning as in claim 1, and X represents a leaving group. The method for producing a diamine derivative according to any one of claims 1 to 4, wherein the compound is reacted with a compound represented by the formula: Formula (2)

[Wherein, R 1, R 2, R 3, R 4, R 5, R 6, R 7, R 8, R 9, R 10 and A represent the same meaning as in claim 1. The compound represented by formula (4 )

[Wherein Q represents the same meaning as in claim 1. The method for producing a diamine derivative according to any one of claims 1 to 4, wherein the compound is reacted with a compound represented by the formula: Formula (5 )

[Wherein, R5, R6, R7, R8, R9, R10 and Q represent the same meaning as in claim 1.] ] A compound represented by the formula (6 )

[Wherein, R1, R2, R3, R4 and A represent the same meaning as in claim 1, and X represents a leaving group. The method for producing a diamine derivative according to any one of claims 1 to 4, wherein the compound is reacted with a compound represented by the formula: Formula (5)

[Wherein, R5, R6, R7, R8, R9, R10 and Q represent the same meaning as in claim 1.] ] A compound represented by the formula (7 )

[Wherein R 1, R 2, R 3, R 4 and A represent the same meaning as in claim 1. The method for producing a diamine derivative according to any one of claims 1 to 4, wherein the compound is reacted with a compound represented by the formula: Formula (8 )

[Wherein R 2, R 3, R 4, R 5, R 6, R 7, R 8, R 9, R 10 and Q represent the same meaning as in claim 1. ] A compound represented by the formula (9 )

[Wherein, R1 and A represent the same meaning as in claim 1, and X represents a leaving group. The method for producing a diamine derivative according to any one of claims 1 to 4, wherein the compound is reacted with a compound represented by the formula: A pest control composition containing the diamine derivative according to any one of claims 1 to 4 and at least one other fungicide and / or insecticide. Other fungicides and / or insecticides are triadimethone, hexaconazole, propiconazole, ipconazole, prochloraz, triflumizole, tebuconazole, epoxiconazole, difenoconazole, flusilazole, triadimenol, cyproconazole, metconazole, fluconazole Quinconazole, Vitertanol, Tetraconazole, Triticonazole, Frutriafor, Penconazole, Diniconazole, Fenbuconazole, Bromuconazole, Imibenconazole, Cimeconazole, Microconazole, Microbutanyl, Himexazole, Imazaryl, Framethopil, Tifluzamide, Etridiazole , Oxyspoconazole, oxyspoconazole fumarate, pefazoate, prothioconazole, pyrifenoc , Fenarimol, nuarimol, bupirimate, mepanipyrim, cyprodinil, pyrimethanil, metalaxyl, oxadixyl, benalaxyl, thiophanate-methyl, benomyl, carbendazim, fuberidazole, thiabendazole, mancozeb, propineb, zineb, metiram, maneb, ziram, thiram, tetrachloroisophthalonitrile, Ethaboxam, oxycarboxin, carboxin, flutolanil, silthiophane, mepronil, dimethomorph, fenpropidin, fenpropimorph, spiroxamine, tridemorph, dodemorph, flumorph, azoxystrobin, cresoxime methyl, metminostrobin, orisatrobin, fluoxastrobin , Trifloxystrobin, dimoxystrobin, pyraclostro Emissions, picoxystrobin, iprodione, procymidone, vinclozolin, chlozolinate, flusulfamide, dazomet, methyl isothiocyanate, chloropicrin, methasulfocarb, hydroxy isoxazole, hydroxy isoxazole potassium, Ekuromezoru, D-D, Kabamu, basic Copper chloride, basic copper sulfate, copper nonylphenol sulfonate, oxine copper, DBEDC, anhydrous copper sulfate, copper sulfate pentahydrate, cupric hydroxide, inorganic sulfur, hydrated sulfur agent, lime sulfur mixture, zinc sulfate, Fentine, sodium bicarbonate, potassium bicarbonate, hypochlorite, metallic silver, edifenphos, tolcrofosmethyl, fosetyl, iprobenphos, dinocap, pyrazophos, carpropamide, fusalide, tricyclazole, pyroxylone, diclosime Phenoxanyl, kasugamycin, validamycin, polyoxins, blasticidin S, teclophthalam, oxytetracycline, mildiomycin, streptomycin, rapeseed oil, benavacarbib isopropyl, iprovaricarb, propamocarb, dietofencarb, fluorimide, fludioxanil, fenpiclonil, probenazole, Acibenzoral S methyl, thiazinyl, cyflufenamide, phenhexamide, quinoxyphene, diflumetrim, metolaphenone, picobenzamide, proquinazide, famoxadone, cyazofamide, phenamidone, zoxamide, boscalid, chlorothalonil, simoxanyl, captan, dithianone, fluazinam, fuldodi The Solonic acid, isoprothiolane, ferrimzone, dichromedin, penciclone, quinomethionate, iminotazine acetate, iminoctadine albesylate, ambam, polycarbamate, thiadiazine, chloroneb, organonickel, guazatine, dozin, quintozene, tolylfluanid, anilazine, nitrotalisopropyl , Fenitropan, dichlorane, DPC, dimethymol, benazole, flumetobar, mandipropamide, (RS) -N- [2- (1,3-dimethylbutyl) thiophen-3-yl] -1-methyl-3-tri Fluoromethyl-1H-pyrazole-4-carboxamide (generic name pending: penthiopyrad), formula (10 )

A compound represented by formula (11 ):

A compound represented by the formula: lamethrin, resmethrin, phenothrin, framethrin, permethrin, cypermethrin, deltamethrin, cyhalothrin, cyfluthrin, fenpropatoline, tralomethrin, cycloprotorin, flucitrinate, fulvalinate, acrinathrin, tephritrine, enpentrin, Beta-cyfluthrin, cypermethrin, fenvalerate, esfenvalerate, flubrocitrinate, methotfluthrin, profluthrin, dimeflusulin, or insecticidal chrysanthemum extract, DDVP, cyanophos, fenthion, fenitrothion, tetrachlorvinphos, dimethylbinphos, propofos, methylparathion , Temefos, Hoxime, Acephate, Isofenphos, Salicione, DEP, EPN Ethion, mecarbam, pyridafenthion, diazinon, pyrimifosmethyl, etrimphos, isoxathion, quinalphos, chlorpyrifosmethyl, chlorpyrifos, hosalon, phosmet, methidathion, oxydebrophos, bamidthione, malathion, phentoate, dimethoate, formothione, thiometholine, prothioterone, prothioterone , Sulprophos, Pyracrofos, Monocrotophos, Naredo, Phostiazete, Trichlorfone, Etoprophos, Kazusafos, Chlorfenvinphos, Diclofenthion, Ethylthiomethone, Metamidophos, Dichlorvos, Tebupyrimphos, Omethoate, Triazophos, Oxydemeton-methyl, Azinephos-methyl, Chlorethoxyphos Dicrotofos, Disulfoton, Fanamifos, Phosamidon, Trichlorfone, Chlormefos, Demeton-S-methyl, Mevinfos, Parathion, Tebuprimfos, NAC, MTMC, MIPC, BPMC, XMC, PHC, MPMC, Ethiophene Carb, Bendiocarb, Pirimicarb, Carbosulfurfan Benfuracarb, mesomil, oxamyl, aldicarb, thiodicarb, aranicarb, carbofuran, methiocarb, phenothiocarb, formethanate, xylylmethyl carbamate, propoxal, isoprocarb, etofenprox, halfenprox, silafluophene, nicotine sulfate, polynactin complex, abamectin, milbectin Repimectin, BT agent, cartap, thiocyclam, benz L-tap, diflubenzuron, chlorfluazuron, teflubenzuron, triflumuron, flufenoxuron, flucycloxuron, hexaflumuron, fluazuron, imidacloprid, nitenpyram, acetamiprid, dinotefuran, thiamethoxam, thiacloprid, clothianidin, pymetozine, fiprozin, proprobinobu , Pyriproxyfen, metoprene, hydroprene, quinoprene, endosulfan, diafenthiuron, triazuron, tebufenozide, benzoepin, nobarulone, nobiflumuron, emamectin, emamectin benzoate, clothianidin, thiacloprid, thiamethoxam, flupirazofos, acexinozole, phenoxazole Ruacripyrim, flufenzine, halofenozide, indoxacarb, methoxyphenozide, spirodiclofen, tolfenpyrad, gamma cyhalothrin, ethiprole, acetoprole, amidoflumet, bistrifluron, flonicamid, flubrocis linate, flufenerim, pyridalyl, spinosad, spiromesifen , Silafluophene, cyromazine, lufenuron, esfenvalerate, sodium oleate, potassium oleate, chlorfenapyr, kelsen, azadirachtin, carbam, carbam sodium, propargite, fenbutatin oxide, bromopropyrate, azocyclotine, benzoximate, Tinomethionate, chlorophenapyl, metaldehyde, triazamate, endosulfan Lindane, Protrifen boot, Aminoflumate, Benclothiaz, Diflovidazine, Flubendiamide, Metaflumizole, Dicophor, Chlorbenzilate, Phenisobromolate, Tetradiphone, CPCBS, BPPS, Quinomethionate, Amitraz, Benzomate, Hexithiazox, Fenbutazin oxide, Cihexatin, Dienochlor, clofentezin, pyridaben, fenpyroximate, phenazaquin, tebufenpyrad, pyrimidifen, formula (12 )

[Wherein R8 represents a methyl group or a chloro group, R9 represents a methyl group, a chloro group, a bromo group or a cyano group, R10 represents a chloro group, a bromo group, a trifluoromethyl group or a cyanomethoxy group, Represents a methyl group or an isopropyl group. A compound represented by the formula (13 )

[Wherein R12 represents a 1,1,1,2,3,3,3-heptafluoro-2-propyl group or a 1,1,2,2,3,3,3-heptafluoro-1-propyl group. To express. The composition for controlling pests according to claim 12, which is selected from compounds represented by the formula: