JP5770684B2 - Optical simulation apparatus and method, and program - Google Patents

Description

  The present invention relates to an optical simulation apparatus, method, and program for performing optical simulation using a simulation model having a multilayer structure including a scattering medium such as skin.

  Conventionally, when designing and developing skin care products such as cosmetics and sunscreens, it is important to know in advance the skin shine and sunscreen suppression effects when these are applied to the skin.

  And as one of the methods for grasping in advance such as skin shine and sunburn suppression effect as described above, what kind of optical properties such as stratum corneum, epidermis and dermis that make up the skin against the light reflection of the skin There is a way to analyze how it affects.

  Here, for example, in Patent Document 1, a reflection spectrum obtained by irradiating light to the skin and a virtual spectrum created by a Monte Carlo simulation using a multilayer structure model of the skin, A method has been proposed in which fitting is performed while changing the scattering coefficient and the like, thereby estimating the optical characteristics of each layer of the skin.

JP 2011-87907 A JP 2012-85878 A

  However, in the simulation by the Monte Carlo method as described in Patent Document 1, it is possible to estimate the optical characteristics of each layer of the skin, but it is not possible to visually and intuitively understand how light propagates in the skin. Have difficulty.

  Patent Document 2 discloses that the skin is modeled by a multilayer structure and simulation is performed when light is incident on the model. However, in Patent Document 2, light propagates through the skin. There is no disclosure of a method that allows the user to visually and intuitively understand how to do.

  In view of the above problems, the present invention can visually and intuitively understand how light propagates in the skin, thereby easily obtaining information necessary for the design and development of cosmetics and skin care products. An object of the present invention is to provide an optical simulation apparatus, method, and program that can be used.

  The optical simulation apparatus of the present invention has a multilayer structure in which a plurality of layers having different optical characteristics are stacked, and a simulation model in which a multilayer structure simulation model in which at least one of the plurality of layers is a scatterer is set Within the multilayer structure simulated by the setting section, the optical simulation section that simulates the temporal change of the spatial distribution of the light intensity in the multilayer structure when light is incident on the simulation model of the multilayer structure, and And a display control unit that displays an image generated based on a temporal change in the spatial distribution of the light intensity on the display unit.

  In the optical simulation apparatus of the present invention, the display control unit can display a plurality of spatial distributions of light intensities acquired at predetermined time intervals in time series.

  In addition, the display control unit can display a moving image by sequentially switching a plurality of spatial distributions of light intensity acquired at predetermined time intervals in time series.

  In addition, the display control unit can display the information of the simulation model having a multilayer structure superimposed on the spatial distribution of the light intensity.

  In addition, the display control unit can display information on the simulation model having a multilayer structure at a position received by a predetermined input unit.

  In addition, the display control unit can display the layer boundary lines of the simulation model having a multilayer structure on the spatial distribution of the light intensity.

  In addition, the display control unit can display an image representing the intensity change portion of the reflected light corresponding to the layer boundary of the simulation model having a multilayer structure over the spatial distribution of the light intensity.

  Further, the display control unit can display information on light intensity at a position received by a predetermined input unit.

  Further, the display control unit can display an image based on an interference signal intensity between the reflected light of the light and the light represented by a spatial distribution of light intensity.

  In addition, at least a part of the multilayer structure can be a part of a living body.

  Further, at least a part of the multilayer structure can be skin or mucous membrane.

  Further, at least a part of the multilayer structure can be a layer composed of a skin and a coating agent applied to the skin.

  Moreover, the boundary of each layer of a multilayer structure can be made into an uneven surface or a curved surface.

  In addition, a region having optical characteristics different from each layer can be locally provided in each layer of the multilayer structure or in a boundary portion.

  The scatterer layer may be modeled by setting the scattering coefficient based on the refractive index, size, and concentration of the fine particles, in which the fine particles are randomly dispersed.

  Further, pulsed light can be used as the light.

  The optical simulation method of the present invention sets a simulation model of a multilayer structure in which a plurality of layers having different optical characteristics are stacked, and at least one of the plurality of layers is a scatterer. Simulate the temporal change of the spatial distribution of light intensity in the multilayer structure when light is incident on the structural simulation model, and generate it based on the temporal change of the spatial distribution of light intensity in the simulated multilayer structure The displayed image is displayed.

  In the optical simulation program of the present invention, a simulation model of a multilayer structure in which a computer has a multilayer structure in which a plurality of layers having different optical characteristics are stacked and at least one of the layers is a scatterer is set. A simulation model setting unit, an optical simulation unit that simulates temporal changes in the spatial distribution of light intensity in the multilayer structure when light is incident on the simulation model of the multilayer structure, and a multilayer that is simulated in the optical simulation unit It is characterized by functioning as a display control unit for displaying an image generated on the basis of a temporal change in the spatial distribution of light intensity in the structure.

  According to the optical simulation apparatus, method, and program of the present invention, a simulation model of a multilayer structure in which a plurality of layers having different optical characteristics are laminated, and at least one of the plurality of layers is a scatterer. Is set, and the time variation of the spatial distribution of light intensity in the multilayer structure when light is incident on the simulation model of the multilayer structure is simulated, and the spatial distribution of light intensity in the simulated multilayer structure Since the image generated based on the time change of the image is displayed on the display unit, for example, if a skin simulation model is set as a simulation model having a multilayer structure, the state of light propagating in the skin can be visually observed. Design and development of cosmetics and skin care products. It can easily obtain the information necessary.

  In the optical simulation apparatus of the present invention, a plurality of light intensity spatial distributions acquired at predetermined time intervals are displayed side by side in time series, or a plurality of light intensity spatial distributions are sequentially switched in time series to display a moving image. For example, a change in reflected light intensity corresponding to a layer boundary in a multilayer structure can be easily grasped visually.

  In addition, when the layer boundary line of the multilayered simulation model is displayed over the spatial distribution of the light intensity, the change in light intensity at the layer boundary of the multilayer structure can be easily grasped. it can.

  In addition, when the image representing the intensity change portion of the reflected light corresponding to the layer boundary of the simulation model having the multilayer structure is displayed with being superimposed on the spatial distribution of the light intensity, for example, the epidermis constituting the skin It is possible to easily grasp the state of the intensity change of the reflected light reflected from the boundary between the skin and the dermis.

  When an image based on the interference signal intensity between the reflected light represented by the spatial distribution of the light intensity and the incident light is displayed, the signal intensity acquired by so-called optical tomography is acquired by simulation. By comparing this with the signal intensity obtained by actually performing optical tomography, it is possible to analyze the influence of each layer of the skin on the signal intensity of optical tomography.

  In addition, when at least a part of the multilayer structure is a layer made of the skin and an application agent applied to the skin, for example, if the layer made of the application agent is a layer of cosmetics or skin care products, the cosmetics or skin care products It is possible to easily grasp the influence of the light on the reflected light from the skin.

  Further, when the boundary of each layer of the multilayer structure is an uneven surface or a curved surface, for example, the state of the tissue in the skin can be modeled more faithfully.

  In addition, when a region having optical characteristics different from each layer is locally provided in each layer or boundary portion of the multilayer structure, for example, a blood vessel region or a pore region may be provided as the above region. The configuration can be modeled more faithfully.

The block diagram which shows schematic structure of one Embodiment of the optical simulation apparatus of this invention The figure which shows an example of the skin simulation model The figure which shows the information of each layer in the skin simulation model shown in FIG. Diagram for explaining FDTD (Finite Difference Time Domain) method The flowchart for demonstrating the effect | action of one Embodiment of the optical simulation apparatus of this invention. The figure which shows the example which arranged and displayed the spatial distribution of the light intensity for every predetermined time interval in time series The figure which shows the example which displayed the boundary line of each layer of the skin simulation model superimposed on the spatial distribution of light intensity The figure which shows the example which overlapped and displayed the boundary line showing the intensity change part of the reflected light corresponding to the layer boundary in the skin simulation model to the spatial distribution of the light intensity The figure which shows an example of the skin simulation model which made the boundary of each layer the uneven surface The figure which shows an example of the skin simulation model which made the boundary of each layer the uneven surface The figure which shows the example which provided the blood vessel region and the pore region in the skin simulation model The figure which shows the example which provided the application layer in the skin simulation model The figure which shows the other example of a skin simulation model The figure which shows the image (graph) which plotted the result of having simulated the OCT signal intensity corresponding to each depth position in a skin simulation model The figure which shows the image (graph) which plotted the result of having simulated the OCT signal strength corresponding to each depth position in other skin simulation models The figure which shows the image (graph) which plotted the result of having simulated the OCT signal strength corresponding to each depth position in other skin simulation models The figure which shows the image (graph) which plotted the result of having simulated the OCT signal strength corresponding to each depth position in other skin simulation models The figure which shows the image (graph) which plotted the result of having simulated the OCT signal strength corresponding to each depth position in other skin simulation models

  Hereinafter, an optical simulation apparatus, method, and program according to an embodiment of the present invention will be described in detail with reference to the drawings. FIG. 1 is a block diagram showing a schematic configuration of the optical simulation apparatus of the present embodiment. The configuration of the optical simulation apparatus shown in FIG. 1 is realized by installing the optical simulation program of the present invention in a computer and executing the program by the computer. The optical simulation program installed in the computer may be stored in a recording medium such as a CD-ROM, or may be distributed via a network such as the Internet.

  As shown in FIG. 1, the optical simulation apparatus 10 of the present embodiment includes a simulation model setting unit 11, an optical simulation unit 12, and a display control unit 13. The optical simulation apparatus 10 uses a monitor 20 for displaying a simulation result in the optical simulation unit 12, a setting input screen for various information used when setting a simulation model, and the like when setting a simulation model. An input unit 30 that receives input of various information is connected.

  The simulation model setting unit 11 is for setting a simulation model to be subjected to optical simulation in the optical simulation unit 12. The simulation model setting unit 11 of this embodiment has a multilayer structure in which a plurality of layers having different optical characteristics are stacked, and a simulation model having a multilayer structure in which at least one of the plurality of layers is a scatterer is set. It is what is done.

  In the present embodiment, a simulation model obtained by modeling the skin of a living body (particularly a human body) is set as the simulation model as described above. Specifically, as shown in FIG. 2, a skin simulation model 40 in which an air layer 41, a horny layer 42, an epidermis layer 43, and a dermis layer 44 are laminated in this order is set. FIG. 3 shows the refractive index, thickness, presence / absence and characteristics of scatterers, and absorption coefficient of each layer in the skin simulation model 40 shown in FIG. The information of each layer shown in FIG. 3 is input by the user using the input unit 30, the input information is acquired by the simulation model setting unit 11, and the simulation model setting unit 11 is based on the input information. A skin simulation model as shown in FIG. 2 is set. As for the information on each layer shown in FIG. 3, a setting input screen may be displayed on the monitor 20 and the user may input using the input unit 30 on the setting input screen. A text file that has been described may be input.

  In the present embodiment, as shown in FIG. 3, the skin layer 43 and the dermis layer 44 among the layers of the skin simulation model 40 are set as layers of the scatterer. The scatterer layer in this embodiment is a dispersion of fine particles randomly, and is modeled by setting the scattering coefficient based on the refractive index, size, and concentration of the fine particles as shown in FIG.

  The refractive index of the scatterer in FIG. 3 is the refractive index of the fine particles, the size of the scatterer is the diameter of the circular fine particles, and the concentration of the scatterer is the area ratio of the fine particles in the scatterer. . In addition to the above information, the refractive index around the fine particles may be set, and the fine particles are not limited to a circle but may have a shape such as a rectangular parallelepiped, a cylinder, or a cone. As a detailed setting method of the simulation model of the scatterer, for example, a method described in Japanese Patent Application Laid-Open No. 2008-190979 can be used.

  In the simulation model setting unit 11, an analysis range to be subjected to optical simulation is also set. In the present embodiment, a square area of 1 mm × 1 mm is set as the analysis range.

  The optical simulation unit 12 simulates temporal changes in the spatial distribution of light intensity in the multilayer structure when pulse light is incident on the simulation model having the multilayer structure set in the simulation model setting unit 11. Then, the optical simulation unit 12 of the present embodiment treats the pulsed light as an electromagnetic wave, and calculates the temporal and spatial changes of the electromagnetic field when the pulsed light is incident on the skin simulation model 40, whereby the skin simulation is performed. The temporal change of the spatial distribution of the light intensity representing the reflection and scattering states of the pulsed light in the model 40 is calculated. In this embodiment, pulsed light is used as incident light, but continuous light may be used.

  Specifically, a FDTD (Finite Difference Time Domain) method calculation program that numerically solves temporal and spatial changes of the electromagnetic field based on the Maxwell equation can be used. In the FDTD method, as shown in FIG. 4, an analysis space that surrounds the distribution of material properties in a continuous space is defined, and the space is divided by a mesh-like minute rectangular parallelepiped. The components of the electromagnetic field vector are arranged as shown in FIG. This arrangement is called a Yee cell. And the time change of the electromagnetic field on this lattice is calculated based on the Maxwell equation. The simulation by the FDTD method using a predetermined refractive index distribution as an analysis space is a known technique, and the simulation by the FDTD method of a scatterer model in which fine particles are dispersed is also known in, for example, Japanese Patent Application Laid-Open No. 2008-190979. Therefore, detailed description is omitted.

  In the present embodiment, as an optical simulation, a simulation using the FDTD method is performed. However, the optical simulation is not limited to the FDTD method. For example, the finite element method, the boundary element method, and other generally known electromagnetic fields are used. Calculation techniques can be used.

  The display control unit 13 displays the spatial distribution of light intensity in the multilayer structure on the monitor 20 based on the simulation result in the optical simulation unit 12. Specifically, the display control unit 13 in the present embodiment reflects and reflects the pulsed light in the skin simulation model 40 when the pulsed light is incident on the skin simulation model 40 based on the simulation result in the optical simulation unit 12. The spatial distribution of the light intensity representing the scattering state is displayed on the monitor 20. A specific display method will be described later in detail. Further, the display control unit 13 displays the setting input screen described above on the monitor 20.

  Next, the operation of the optical simulation apparatus 10 of the present embodiment will be described with reference to the flowchart shown in FIG.

  First, on the monitor 20, a setting input screen for receiving information on each layer of the skin simulation model 40 described above is displayed by the display control unit 13, and information such as the refractive index of each layer of the skin simulation model 40 using the input unit 30 by the user. Is input (S10).

  Next, the information of each layer received by the input unit 30 is input to the simulation model setting unit 11, and the skin simulation model 40 is set based on the input information of each layer in the simulation model setting unit 11 (S12). ).

  The skin simulation model 40 set in the simulation model setting unit 11 is input to the optical simulation unit 12, and the optical simulation as described above is performed in the optical simulation unit 12, whereby pulse light is applied to the skin simulation model 40. The temporal change of the spatial distribution of the light intensity in the skin simulation model 40 at the time of incidence is calculated, and the spatial distribution of the light intensity for each predetermined time interval is acquired (S14).

  Then, the spatial distribution of the light intensity for each predetermined time interval acquired in the optical simulation unit 12 is input to the display control unit 13, and the display control unit 13 causes the monitor 20 to display the input spatial distribution of the light intensity. (S16).

  Here, an example of the spatial distribution of the light intensity displayed on the monitor 20 by the display control unit 13 is shown in FIG. As shown in FIG. 6, the display control unit 13 according to the present embodiment displays the spatial distribution of light intensity acquired at predetermined time intervals in time series. FIG. 6 shows the light intensity space when the wavelength of the pulsed light is 1300 nm, the pulse width is 140 fs, the beam diameter is 17 μm, and this pulsed light is incident on the skin simulation model 40 shown in FIGS. The distribution is displayed, and the spatial distribution of the light intensity for each time interval 217 fs is displayed in time series. The numbers shown in FIG. 6 are in chronological order.

  According to the optical simulation apparatus 10 of the above-described embodiment, the skin simulation model 40 is set, and the temporal change in the spatial distribution of light intensity in the skin simulation model 40 when light is incident on the skin simulation model 40. Since the simulation is performed and an image generated based on the temporal change of the spatial distribution of the simulated light intensity is displayed on the monitor 20, it is possible to visually and intuitively understand how light propagates in the skin. The information necessary for the design and development of cosmetics and skin care products can be easily obtained.

  In the description of the above embodiment, the spatial distribution of the light intensity acquired at predetermined time intervals is displayed side by side in time series. However, the present invention is not limited to this, and a plurality of lights as shown in FIG. Of the spatial distribution of intensities, the spatial distribution of one light intensity arbitrarily selected by the user or the spatial distribution of one light intensity automatically extracted may be displayed on the monitor 20.

  Further, as shown in FIG. 7, layer boundary lines B1 to B3 may be superimposed and displayed as information of the skin simulation model 40 with respect to a spatial distribution of a predetermined light intensity. A boundary line B1 shown in FIG. 7 is a boundary line between the air layer 41 and the stratum corneum 42 in the skin simulation model 40, and a boundary line B2 is a boundary line between the epidermis layer 43 and the stratum corneum 42, and the boundary line B3 Is a boundary line between the dermis layer 44 and the epidermis layer 43. Further, the information of the skin simulation model 40 superimposed on the light intensity spatial distribution is not limited to the layer boundary line, and for example, each layer of the skin simulation 40 may be superimposed on the light intensity spatial distribution as a transmission image of a different color. .

  Further, in accordance with the operation of the input unit 30 such as the user's mouse, the cursor may be moved on the screen of the monitor 20 to display information on the skin simulation model 40 corresponding to the cursor position on the screen. Specifically, for example, as the information of the skin simulation model 40, the thickness and refractive index of each layer as shown in FIG. 3, information on the scatterer (refractive index, size and concentration of fine particles), absorption coefficient, and the like are displayed. May be.

  In addition, as shown in FIG. 8, a boundary line B4 representing the intensity change portion of the reflected light corresponding to the layer boundary in the skin simulation model 40 may be superimposed and displayed on the spatial distribution of the predetermined light intensity. Good. A boundary line B4 shown in FIG. 8 represents the intensity change portion of the reflected light corresponding to the layer boundary between the skin layer 43 and the dermis layer 44. The boundary line B4 may be set based on a simulation result in the optical simulation unit 12, or may be set by image analysis of a spatial distribution of light intensity.

  Further, in accordance with the operation of the input unit 30 such as the user's mouse, the cursor may be moved on the screen of the monitor 20 to display the light intensity information of the reflected light corresponding to the cursor position on the screen.

  Further, in the description of the above embodiment, the spatial distribution of the light intensity acquired at every predetermined time interval is displayed in time series. However, the present invention is not limited to this, and the light intensity is acquired at every predetermined time interval. The spatial distribution of the light intensity may be sequentially switched and displayed on the monitor 20 to be displayed as a moving image.

  In addition, as described above, instead of displaying a moving image by automatically sequentially switching the spatial distribution of light intensity acquired at predetermined time intervals, for example, when the user clicks the mouse as the input unit 30 The spatial distribution of the light intensity acquired at predetermined time intervals may be manually switched sequentially in accordance with the timing at which the keyboard as the input unit 30 is pressed. Specifically, the spatial distribution of the light intensity is switched frame by frame in the order of passage of time according to the click of the user's mouse, or the spatial distribution of the light intensity is frame by frame in the reverse order of the passage of time. It may be switched and displayed.

  Further, the configuration of the skin simulation model 40 is not limited to the configuration shown in FIG. 2, and for example, as shown in FIG. 9, the boundary between the dermis layer 44 and the epidermis layer 43 may be an uneven surface 45. . Moreover, it is good also as a curved surface instead of an uneven surface. Thus, by making the boundary into an uneven surface or a curved surface, it is possible to make it closer to the actual skin state, and it is possible to model various skin states and perform optical simulation.

  In addition to the boundary between the dermis layer 44 and the skin layer 43, a horny layer 46 having an uneven surface may be provided on the skin layer 43 as shown in FIG. As a result, the actual texture of the skin can be expressed.

  Furthermore, a region having optical characteristics different from that of each layer may be locally provided in each layer or boundary portion of the skin simulation model 40. Specifically, as shown in FIG. 11, a region 48 representing blood vessels is provided in the dermis layer 44, or a region 47 representing pores is provided at the boundary between the horny layer 42 and the epidermis layer 43. Also good. In addition, the absorption coefficient and refractive index different from the absorption coefficient and refractive index of each layer shall be assigned to the area | region showing the blood vessel mentioned above and the area | region showing a pore, for example.

  Also, as shown in FIG. 12, on the horny layer 42 of the skin simulation model 40, for example, an application layer 49 in which an application agent such as cosmetics such as a foundation applied on the skin or skin care products such as sunscreen is modeled. May be provided. Thus, by providing the coating layer 49 and performing the above-described optical simulation and displaying the result on the monitor 20, it is possible to visually confirm the effect of suppressing skin shine and the effect of sunscreen by cosmetics. . Further, since various information can be set as the refractive index and scatterer information of the coating layer 49, the effects of a wide variety of cosmetics and skin care products can be confirmed on the monitor 20.

  In the description of the above embodiment, the simulation result by the optical simulation device 10 is displayed on the monitor 20 so that the reflection or scattering state of light on the actual skin can be visually confirmed. The contents that can be confirmed by the simulation result of 10 are not limited to this. For example, the simulation result by the optical simulation apparatus 10 is used to calculate the signal intensity (hereinafter referred to as OCT signal intensity) of so-called optical tomography (OCT). By calculating and displaying the result on the monitor 20, it is possible to visually confirm the OCT signal intensity when optical tomography is performed by irradiating light to the skin or mucous membrane, for example. Used to analyze OCT signal intensity acquired by Can. Hereinafter, the case where the OCT signal intensity is calculated and displayed as described above will be described.

  First, a skin simulation model 50 set in the simulation model setting unit 11 is shown in FIG. A skin simulation model 50 shown in FIG. 13 is formed by laminating a first scatterer layer 51 and a second scatterer layer 52. The thickness of the first scatterer layer 51 is set to 150 μm, and the thickness of the second scatterer layer 52 is set to 500 μm. Here, the concentration of the fine particles in the first scatterer layer 51 is 3%, and the concentration of the fine particles in the second scatterer layer 52 is 10%. It is assumed that the same predetermined value is set in the first scatterer layer 51 and the second scatterer layer 52 for the refractive index and size of the fine particles.

  The skin simulation model 50 as described above is input to the optical simulation unit 12, and the optical simulation unit 12 performs an optical simulation similar to that of the above embodiment using the input skin simulation model 50. In other words, the optical simulation unit 12 simulates temporal changes in the spatial distribution of light intensity in the skin simulation model 50 when pulse light is incident on the skin simulation model 50.

  Then, the optical simulation unit 12 acquires the spatial distribution of the light intensity for each predetermined time interval, and outputs this to the display control unit 13 as in the above embodiment.

  The display control unit 13 calculates the OCT signal intensity based on the spatial distribution of the light intensity at every input predetermined time interval. Specifically, the display control unit 13 calculates the OCT signal intensity by calculating the interference signal intensity between the reflected light of the pulsed light represented by the spatial distribution of each light intensity and the pulsed light that is the incident light. . As a method for calculating the optical interference signal intensity, a known method can be used.

  Based on the OCT signal intensity calculated as described above, an image (graph) in which the OCT signal intensity corresponding to each depth position in the skin simulation model 50 is plotted as shown in FIG. To display. In addition, below the graph of FIG. 14, the spatial distribution of each light intensity used when calculating the OCT signal intensity | strength of each depth position shown with a dotted line is shown. The spatial distribution of light intensity shown in FIG. 14 is arranged in time series from left to right. Note that the horizontal axis of the OCT signal intensity graph shown in FIG. 14 can be read as the time axis.

  From the OCT signal intensity graph shown in FIG. 14, it can be seen that the boundary portion between the first scatterer layer 51 and the second scatterer layer 52 in the skin simulation model 50 appears as a step. For comparison, FIGS. 15 to 18 show graphs of the OCT signal intensity when the concentration of the fine particles in the first scatterer layer 51 and the second scatterer layer 52 is changed.

  FIG. 15 shows a graph of the OCT signal intensity when the concentration of the fine particles in the first scatterer layer 51 and the second scatterer layer 52 is both 3%. In this case, the step as shown in the graph of FIG. 14 does not occur.

  FIG. 16 is a graph showing the OCT signal intensity when the concentration of the fine particles in the first scatterer layer 51 is 3% and the concentration of the fine particles in the second scatterer layer 52 is 30%. In this case, there is a larger step than the graph of FIG.

  FIG. 17 is a graph showing the OCT signal intensity when the concentration of the fine particles in the first scatterer layer 51 is 1% and the concentration of the fine particles in the second scatterer layer 52 is 10%. In this case as well, a larger step is generated than in the graph of FIG.

  Further, the graph shows the OCT signal intensity when the concentration of fine particles in both the first scatterer layer 51 and the second scatterer layer 52 is 10%. In this case, the step as shown in the graph of FIG. 14 does not occur, and the degree of decrease in the OCT signal strength is larger than that of the OCT signal strength graph shown in FIG.

  By comparing and analyzing the calculation results of the OCT signal intensity as shown in FIG. 14 to FIG. 18 and the OCT signal intensity actually obtained by optical tomography, the skin or the like actually subjected to optical tomography is analyzed. The state can be grasped.

  In the description of the above embodiment, the simulation model of the living body skin is set as the simulation model of the multilayer structure. However, the simulation model applicable to the present invention is not limited to these, for example, a mucous membrane simulation model, A simulation model of a printed material in which paper and an ink layer are laminated, or a simulation model of a laminated structure including a scatterer layer such as a paint film may be applied. Then, optical simulation similar to the above is performed using these simulation models, and an image based on the result is displayed on the monitor 20, which can be useful for paper and ink development and coating film design.

DESCRIPTION OF SYMBOLS 10 Optical simulation apparatus 11 Simulation model setting part 12 Optical simulation part 13 Display control part 20 Monitor 30 Input part 40,50 Skin simulation model 41 Air layer 42 Corneal layer 43 Epidermis layer 44 Dermal layer 45 Uneven surface 47 The area | region 48 which represents a pore 48 Blood vessel The area 49 representing the coating layer 51 The first scatterer layer 52 The second scatterer layer

Claims (18)

A simulation model setting unit configured to set a simulation model of a multilayer structure in which a plurality of layers having different optical characteristics are stacked, wherein at least one of the plurality of layers is a scatterer;
An optical simulation unit that simulates temporal changes in the spatial distribution of light intensity in the multilayer structure when light is incident on the simulation model of the multilayer structure;
An optical simulation apparatus comprising: a display control unit configured to display an image generated based on a temporal change in a spatial distribution of light intensity in the multilayer structure simulated in the optical simulation unit. .   The optical simulation apparatus according to claim 1, wherein the display control unit displays a plurality of spatial distributions of the light intensities acquired at predetermined time intervals in time series.   The optical simulation apparatus according to claim 1, wherein the display control unit is configured to sequentially switch a plurality of spatial distributions of the light intensities acquired at predetermined time intervals in time series and display them as moving images.   4. The optical simulation according to claim 1, wherein the display control unit displays information of the simulation model of the multilayer structure on the spatial distribution of the light intensity in an overlapping manner. 5. apparatus.   5. The optical simulation apparatus according to claim 4, wherein the display control unit displays information on the simulation model of the multilayer structure at a position received by a predetermined input unit.   The optical simulation apparatus according to claim 4, wherein the display control unit displays a layer boundary line of the simulation model having the multilayer structure on the spatial distribution of the light intensity.   The display control unit is configured to display an image representing an intensity change portion of reflected light corresponding to a layer boundary of the multilayered simulation model over the spatial distribution of the light intensity. The optical simulation apparatus according to claim 1.   8. The optical simulation apparatus according to claim 1, wherein the display control unit displays information on light intensity at a position received by a predetermined input unit.   The optical simulation according to claim 1, wherein the display control unit displays an image based on an interference signal intensity between the reflected light of the light and the light represented by a spatial distribution of the light intensity. apparatus.   The optical simulation apparatus according to claim 1, wherein at least a part of the multilayer structure is a part of a living body.   The optical simulation apparatus according to claim 10, wherein at least a part of the multilayer structure is skin or mucous membrane.   12. The optical simulation apparatus according to claim 11, wherein at least a part of the multilayer structure is a layer made of the skin and a coating agent applied to the skin.   The optical simulation apparatus according to claim 1, wherein a boundary between the layers of the multilayer structure is an uneven surface or a curved surface.   14. The optical simulation apparatus according to claim 1, wherein a region having optical characteristics different from that of each of the layers is locally provided in each layer or in a boundary portion of the multilayer structure.   The scatterer layer is formed by randomly dispersing fine particles, and is modeled by setting a scattering coefficient based on a refractive index, a size, and a concentration of the fine particles. The optical simulation apparatus according to any one of 1 to 14.   The optical simulation apparatus according to claim 1, wherein the light is pulsed light. A multilayer structure in which a plurality of layers having different optical properties are stacked, and a simulation model of a multilayer structure in which at least one of the plurality of layers is a scatterer is set,
Simulating the temporal change of the spatial distribution of light intensity in the multilayer structure when light is incident on the simulation model of the multilayer structure;
An optical simulation method, comprising: displaying an image generated based on a temporal change of a spatial distribution of light intensity in the simulated multilayer structure. A simulation model setting unit configured to set a simulation model of a multilayer structure in which a plurality of layers having different optical characteristics are stacked, wherein at least one of the plurality of layers is a scatterer;
An optical simulation unit that simulates temporal changes in the spatial distribution of light intensity in the multilayer structure when light is incident on the simulation model of the multilayer structure;
An optical simulation program that functions as a display control unit that causes a display unit to display an image generated based on a temporal change of a spatial distribution of light intensity in the multilayer structure simulated in the optical simulation unit.