JP6254644B2 - Syringe - Google Patents

Description

  The present invention relates to a syringe for injecting a substance to be injected into an injection target region of a living body.

  In a needleless syringe that performs injection without going through an injection needle, a configuration is generally adopted in which injection components are injected by applying pressure to an injection solution containing a drug or the like with explosives, pressurized gas, a spring, or the like. The Then, the pressure applied to the injection solution is adjusted so that the injection solution can be sent to a desired region in the living body. Here, the technique disclosed in Patent Document 1 discloses a configuration in which a gas generating agent for performing pressurization and an injection solution are formed in one unit, and the unit is loaded into a syringe body for use. In this configuration, the unit inserted into the syringe body is ready for use with the lid covering it closed. And after use, the next injection becomes possible by loading a new unit.

  Patent Document 2 discloses a configuration in which a portion that holds an injection solution and a pressurization portion that applies pressure to the injection solution are made independent. In the said structure, after injection | pouring of injection solution, the next injection is attained by exchanging the part which hold | maintains injection solution, and the power source of a pressurization part, respectively.

US Pat. No. 6,258,063 Special table 2003-535654 gazette US Patent Application Publication No. 2003/0114789

  When injecting an injection solution into an injection subject regardless of the presence or absence of an injection needle, in order to deliver the type and amount of the injection solution and the injection solution to the target site, depending on the person to be injected and the purpose of the injection Conditions relating to injection, such as the magnitude of the load to be applied to the injection solution, vary. Therefore, in order to realize injection under the target condition, the configuration of the syringe needs to be in accordance with the condition, and the convenience for the user is not always good.

  In view of the above problems, an object of the present invention is to provide a syringe that easily realizes injection of an injection solution according to various purposes and has improved user convenience.

  In order to solve the above-mentioned problems, the present invention is provided with a configuration for defining an arrangement of components of the syringe, which is loaded into the housing of the syringe, in the syringe. By adopting such a configuration, when each component is loaded into the syringe for injection, even if the loading order of the components is wrong, the user can quickly correct the error by the configuration for the regulation. Therefore, the convenience of the syringe can be improved.

Specifically, the present invention is a syringe for injecting an injection target substance into an injection target region of a living body, and includes a housing, a holding part for storing the injection target substance, and the injection purpose stored in the holding part. A drive unit that applies energy to the substance for injection from the holding unit; and a channel through which the injection target substance injected from the holding unit flows, and an injection target region from an open end of the channel A nozzle portion for injecting the injection target substance. And the state which can inject | emit the said injection target substance is formed by the said holding | maintenance part, the said drive part, and the said nozzle part being independently loaded with respect to the said housing. Furthermore, the syringe has the holding unit with respect to the housing such that a loading state in which the holding unit and the driving unit are always loaded in the same row in the housing for injection of the injection target substance is formed. And a defining means for defining the loading position of the drive unit and the drive unit.

  In the syringe according to the present invention, the holding part, the drive part, and the nozzle part, which are constituent parts, are independently loaded in the housing, whereby preparation for injection of the injection target substance is performed. In the syringe, the injection energy is applied to the injection target substance stored in the holding unit by the drive unit, so that the injection target substance flows through the flow path of the nozzle portion, and the injection is performed from the open end of the flow path. Injected to the target area. This injection target substance contains a component expected to have an effect inside the injection target region, and the injection energy applied by the drive unit as described above is a drive source at the time of injection. Therefore, if injection by the drive unit is possible, the specific physical form of the injection target substance such as the accommodation state of the injection target substance in the syringe, the fluid such as liquid or gel, the powder, the granular solid, etc. It doesn't matter.

  For example, the injection target substance is a liquid, and even if it is a solid, it may be a gel-like solid as long as fluidity enabling injection is ensured. Furthermore, the injection target substance may be in a powder state. The injection target substance includes a component to be sent to the injection target region of the living body, and the component may exist in a state dissolved in the injection target substance, or the component is simply mixed without being dissolved. It may be in the state where it was done. For example, as ingredients to be delivered, there are vaccines for antibody enhancement, proteins for cosmetics, cultured cells for hair regeneration, etc., so that these can be injected into fluids such as liquids and gels. By inclusion, a substance for injection is formed.

  In addition, as the application mode of the injection energy to the injection target substance by the drive unit, various energy sources can be used as long as the injection target substance can be injected. For example, those using the pressure of gas generated by the combustion of explosives and those using an electric actuator (motor, piezo element, etc.) for pressurization are examples of energy sources for injection.

  Here, when the injection target substance is supplied to the living body using the syringe according to the present invention, there are individual differences such as the size, age, and sex of the living body, and the injection target substance used depending on the difference in the effect to be expressed. Different types. In addition, the thickness of each layer in living tissue such as epidermis, intradermal, subcutaneous, and muscle layers varies depending on the injection target region, and in order to reach the injection target substance at each depth, the load to be applied to the injection target substance is also different. Need to adjust. Therefore, in the syringe, a holding unit that stores the injection target substance, a drive unit that applies injection energy to the injection target substance stored therein, and a flow path for performing injection of the injection target substance The nozzle parts having the above are configured independently of each other, and each is independently loaded into the housing.

  That is, in the holding unit for storing the injection target substance, a plurality of types and amounts of the injection target substance are prepared, and in the driving unit, as an energy source for supplying the injection energy to the injection target substance. A plurality of forms are prepared, and are combined and used in a syringe housing according to the purpose of injection. Further, by preparing a plurality of modes for the nozzle portion and including them in the above combination, a mode of injection of the injection target substance (for example, injection of a plurality of injection target substances into the injection target region, It is easy to adjust the flow diameter). Thus, by making it possible to appropriately combine the components of the syringe according to the purpose of injection, the usefulness and convenience of the syringe according to the present invention are improved.

  Here, the plurality of types of drive units means that, for example, when the energy source is an explosive or a gas generating agent, there are a plurality of different amounts, shapes, dimensions, etc., and when a pressurized gas is used as the energy source Is to vary the filling amount of the gas. Furthermore, when the energy source is a spring, there are a plurality of those having different spring constants. In addition, the plurality of holding parts means that there are a plurality of different types or amounts of the injection target substances to be filled.

  Then, by appropriately combining the holding portion, the drive portion, and further the nozzle portion and loading the housing, various injections of the injection target substance according to the injection purpose as described above can be easily realized. On the other hand, if the loading order of the components in the housing is incorrect, the syringe may not function normally. In such a case, it is preferable that the user can immediately recognize an error in the loading order, thereby increasing the convenience of the syringe. In addition, it can be said that it is preferable to perform the loading order of each component correctly because it leads to stable performance of the syringe and can achieve injection with good reproducibility.

  Therefore, the syringe according to the present invention is provided with a defining means for defining at least the loading position of the holding portion and the drive portion with respect to the housing. When the holding unit and the driving unit are loaded in the housing, the injection energy supplied from the driving unit is applied to the injection target substance accommodated in the holding unit, so that the injection is realized, The loading position of the holding unit and the driving unit with respect to the housing is set to a predetermined position. Therefore, if a holding part or the like is loaded at a position different from the predetermined position, the injection target substance cannot be suitably ejected by the syringe. However, in the syringe according to the present invention, since the loading position of the holding portion or the like with respect to the housing is uniquely defined by the above-described defining means, in other words, the loading portion in which the holding portion and the driving portion are defined. Since it is not in a state of being loaded in the housing at a position other than the position, if the loading order of the holding portion or the like is wrong, the user can immediately recognize the error. This makes it possible to realize various injection modes by appropriately combining the components without impairing the convenience for the user.

  The holding unit may be discarded after being used once, and injection may be performed by incorporating a new holding unit. At this time, the drive unit and the nozzle unit may be used only once, and a new drive unit or the like may be used after use. Alternatively, the driving unit and the nozzle unit may be used repeatedly or continuously several times as long as they can be used repeatedly. In addition, the housing of the syringe can basically be used repeatedly. Therefore, it is not necessary to own a plurality of housings for the purpose of injection, and management of the components of the syringe is easy.

  In addition, with respect to the holding unit and the driving unit whose loading positions are defined by the defining means, before the holding unit and the driving unit are loaded into the housing, for example, they are temporarily fixed to each other with adhesive tape or glue. May be loaded. Or you may load a holding | maintenance part and a drive part inside a housing separately. Further, the nozzle portion may be included as the loading position is defined by the defining means. In the case of the nozzle part, since a flow path for injecting the injection target substance is included, it is considered that the loading order is relatively easy for the user, but in the present invention, as described above, the loading position of the nozzle part is also specified. It does not exclude what is prescribed by means.

Here, in the syringe, the drive unit includes an explosive or a gas generating agent that burns by an applied voltage from a power supply unit, and via a pressure of combustion gas generated by the combustion of the explosive or the gas generating agent, You may comprise so that injection energy may be provided to the said injection target substance. In that case, the defining means is formed so that a loading state is formed in which the power supply unit, the holding unit, and the driving unit are always loaded in the same arrangement in the housing for injection of the injection target substance. You may prescribe | regulate the loading position of this power supply part with respect to this housing, this holding | maintenance part, and this drive part. That is, by defining the loading position of each component with respect to the housing by the defining means, including the power supply unit, various injection modes can be realized by appropriately combining the components without impairing the convenience for the user. It can be realized.

  In the above aspect, the loading position of the power supply unit is defined by the defining unit, but instead, the loading position of the power supply unit may not be defined by the defining unit. That is, in the case where the power supply unit is provided in a syringe, the defining means is a loading state in which the holding unit and the driving unit are always loaded in the same arrangement in the housing for injection of the injection target substance. The mounting position of the holding unit and the driving unit with respect to the housing is defined such that the power supply unit defines the loading position by the defining means when loading the housing. You may make it not break. Depending on the storage capacity of the power supply unit, it may be possible to apply a voltage required for combustion of explosives or the like to the drive unit multiple times. In such a case, since it is not necessary to remove the power supply unit from the housing for every injection of the injection target substance, it is not necessary to include it in the target for defining the loading position by the defining means. In addition, depending on the storage capacity, convenience in replacement and the like is improved when the power supply unit can be removed from the housing independently of the drive unit and the holding unit.

  Here, in the loading of the housing with the syringe up to the above, the drive portion, the holding portion, and the nozzle portion are formed so as to overlap each other in the axial direction of the housing, and the opening is formed in the housing. The drive unit, the holding unit, and the nozzle unit may be sequentially loaded from one direction through the unit. In this case, the defining means is a continuous outer peripheral surface formed from the driving unit to the holding unit when the driving unit, the holding unit, and the nozzle unit are overlapped with each other. A first tapered surface formed so that the radius of the continuous outer peripheral surface increases as it goes to the holding portion, and a continuous inner peripheral surface on the housing side, corresponding to the first tapered surface, A second tapered surface.

  That is, the first tapered surface provided on the component side formed by overlapping the drive unit, the holding unit, and the nozzle unit, and the second tapered surface provided on the housing side loaded with the corresponding component. Thus, the defining means is formed. The radii of these tapered surfaces are formed so as to increase toward the opening into which the component is loaded inside the housing. For this reason, since the radius increases in the order of the drive unit, the holding unit, and the nozzle unit, if it is attempted to load the holding unit or nozzle unit into the housing before the drive unit, the nozzle unit is loaded. Since the nozzle part cannot enter deeper than the position, the drive part cannot be loaded as a result, and the user immediately recognizes that the loading order of the constituent parts of the syringe is wrong. Can do.

  Further, instead of using the tapered surface as described above, the defining means includes an outer peripheral surface of the driving unit and an outer peripheral surface of the holding unit having a radius larger than the radius of the outer peripheral surface of the driving unit. A first outer peripheral surface including a first outer peripheral surface, and an inner peripheral surface formed stepwise on the housing side, the second inner peripheral surface corresponding to the first outer peripheral surface. May be configured. As described above, by using the stepped outer peripheral surface and inner peripheral surface with different radii, in other words, the outer peripheral surface that is not continuous between the drive unit and the holding unit and the corresponding inner peripheral surface of the housing, the drive unit and the holding unit are used. It is possible to define the loading position of the part. In the above invention, the drive unit and the holding unit can be arranged coaxially with respect to the housing, and the power supply unit and the nozzle unit can also be arranged coaxially.

  In addition, when loading the housing, if the loading order of a certain component is wrong, the loading of another component is inhibited by reaching the loading position where the component is originally loaded. As long as it is possible to make the user recognize an error in the loading order, another specific embodiment of the defining means may be employed in the syringe according to the present invention.

  Here, in the syringe up to the above, the driving unit has a driving unit side opening which is an opening for applying the ejection energy to the holding unit, and the holding unit is configured to transfer the injection target substance. You may comprise so that it may have an accommodation hole side to receive, and this accommodation hole has an accommodation hole side edge part which receives the said injection | emission energy provided from the said drive part side opening part. In this case, an annular projection that surrounds the drive portion side opening or the accommodation hole side end, and the annular projection deforms in the loaded state, so that the drive portion side opening and the accommodation An annular projection that seals the space between the hole side end is provided on either the drive unit side or the holding unit side. Alternatively, it is an annular groove surrounding the drive part side opening or the receiving hole side end, and the annular protrusion fits in the loaded state, so that the drive part side opening An annular groove that seals the space between the housing and the receiving hole side end is provided on the other side of the drive unit side or the holding unit side.

  The injection energy emitted from the drive unit side opening of the drive unit is transmitted to the accommodation hole side end of the holding unit, so that the injection energy is applied to the injection target substance contained in the accommodation hole. become. Here, as described above, in the syringe according to the present invention, the drive unit and the holding unit are independently configured and loaded into the housing. For this reason, if the injection energy is not suitably applied between the drive unit and the holding unit, the injection target substance is not injected well into the injection target region. Therefore, as described above, by providing a deformable annular protrusion on the drive part side or the holding part side, or on the drive part side and the holding part side, an annular protrusion part and an annular groove part that are fitted to each other are provided. By providing each, the sealing performance in the space between the drive unit side opening and the receiving hole side end is improved, and the emission energy transmitted from the drive unit side is suppressed as much as possible from leaking to the outside. Is possible. Thereby, the injection | pouring of the injection target substance to the injection | pouring object area | region can be performed favorably.

  It is possible to provide an injection device that easily realizes injection of an injection solution according to various purposes and has improved user convenience.

It is sectional drawing which shows schematic structure in the assembly completion state of the syringe which concerns on the 1st Example of this invention. In the syringe shown in FIG. 1, it is a figure which shows the relative relationship of each structure part with the order which loads the structure part of this syringe. FIG. 2 is a diagram for explaining a mode in which the power supply unit is loaded in a different order from the loading order shown in FIG. 1 in the syringe shown in FIG. 1. In the syringe shown in FIG. 1, it is a 1st figure which shows the detailed relative relationship of a drive part and a holding | maintenance part. FIG. 4 is a second view showing a detailed relative relationship between the drive unit and the holding unit in the syringe shown in FIG. 1. In the syringe which concerns on the 2nd Example of this invention, it is a figure which shows the relative relationship of each structure part with the order which loads the structure part of this syringe.

  Hereinafter, a syringe 70 according to an embodiment of the present invention will be described with reference to the drawings. The syringe 70 according to the embodiment of the present invention is a needleless syringe that does not have a so-called injection needle, but the present invention is applied regardless of the presence or absence of the injection needle as long as the gist of the present invention does not change. Is possible. The configuration of the following embodiment is an exemplification, and the present invention is not limited to the configuration of this embodiment.

  FIG. 1 is a cross-sectional view showing a schematic configuration of the syringe 70 in a state where the assembly is almost completed in the syringe 70 according to the present invention. Moreover, FIG. 2 is a figure which shows the loading order of the component part for assembling the syringe 70. As shown in FIG. As shown in FIG. 2, in the syringe 70, the power supply unit 1, the drive unit 2, the holding unit 3, and the nozzle unit 4, which are components of the syringe 70, are sequentially loaded in the housing 5 serving as a main body. These components are fixed to the housing 5 by the fixing ring 6 and assembled.

  Specifically, the housing 5 is formed in a hollow shape so that the power supply unit 1, the drive unit 2, the holding unit 3, and the nozzle unit 4 can be loaded into the housing at one end side in the axial direction. Opening 52 is formed. On the other hand, on the other end side in the axial direction of the housing 5, an opening provided so that the top of the pushbutton switch 11 provided in the power supply unit 1 that is initially loaded in the housing 5 is exposed as will be described later. 53 is formed. The hollow portion in the housing 5 is formed as a tapered surface 50 having a continuous inner peripheral surface, and the radius of the tapered surface 50 (inner diameter of the housing 5) advances from the opening 53 to the loading opening 52. In other words, it is formed so as to increase along the axis of the housing 5. In the present embodiment, in the syringe 70, the opening 53 side of the housing 5 is referred to as an upstream side, and the loading opening 52 side is referred to as a downstream side. This is based on the direction of flow when the injection liquid 34 is ejected in a state where each component is loaded in the housing 5 and the syringe 70 is assembled.

  Here, in the syringe 70, the power supply unit 1, the driving unit 2, the holding unit 3, and the nozzle unit 4 are provided as individually configured components that are independently formed. 1 are sequentially loaded into the interior of the device to form the loaded state shown in FIG. The power source unit 1 is a power source for supplying power to an igniter 22 provided in the driving unit 2 described later. When the user presses the push button switch 11, the power of the battery held therein is used. An applied voltage is generated between the power supply side electrodes 12. The power supply side electrode 12 is formed as a pair of electrodes of a protruding first electrode located on the central axis of the syringe 70 (housing 5) and a protruding second electrode separated from the electrode by a predetermined distance. Is done.

  Next, the drive part 2 has the gas generating agent 25 in the inside, and the pressure of the combustion gas generated when the gas generating agent 25 burns is used as the injection energy of the injection solution stored in the holding part 3 to be described later. Give. Specifically, a drive unit side electrode 21 corresponding to the power supply side electrode 12 of the power supply unit 1 is formed on the end face of the drive unit 2. The drive unit side electrode 21 is formed in a circular shape having a minute circular first electrode located on the central axis of the syringe 70 (housing 5) and a radius equal to the predetermined distance with the first electrode as a center. The second electrode is formed as a pair of electrodes. By forming the drive unit side electrode 21 in this way, the drive unit side electrode 21 regardless of the relative position of the power supply unit 1 with respect to the drive unit 2 (relative position in the rotation direction around the central axis of the syringe 70). And the power supply unit side electrode 12 can be favorably maintained.

  The drive unit side electrode 21 is connected to an igniter 22 provided in the drive unit 2. The igniter 22 is a known electric ignition device. When a voltage is applied between the drive unit side electrodes 21 from the power supply unit 1, a current flows, whereby the igniter provided in the igniter 22 is burned. At this time, a combustion product resulting from the combustion of the igniting agent flows toward the gas generating agent 25 arranged in the combustion chamber 24 adjacent to the igniter 22, and as a result, the combustion of the gas generating agent 25 in the combustion chamber 24. Is started. The combustion gas is rapidly generated by the combustion of the gas generating agent 25, whereby pressure is applied to the metal piston 23 provided adjacent to the combustion chamber 24, and the piston 23 is disposed downstream of the syringe 70. It will be promoted toward the side. In FIG. 1, the end of the combustion chamber 24 closed by the piston 23 on the side of the holding unit 3 serves as a driving unit side opening.

The igniter used in the igniter 22 is preferably an explosive containing zirconium and potassium perchlorate (ZPP), an explosive containing titanium hydride and potassium perchlorate (THPP), titanium and potassium perchlorate. Gunpowder containing (TiPP), Gunpowder containing aluminum and potassium perchlorate (APP), Gunpowder containing aluminum and bismuth oxide (ABO), Gunpowder containing aluminum and molybdenum oxide (AMO), Gunpowder containing aluminum and copper oxide (ACO) ), Explosives containing aluminum and iron oxide (AFO), or explosives composed of a combination of these explosives. These explosives generate high-temperature and high-pressure plasma at the time of combustion immediately after ignition, but exhibit a characteristic that the generated pressure rapidly decreases because the combustible organisms do not contain gas components when they become room temperature.

  Moreover, as the gas generating agent 25 arrange | positioned in the combustion chamber 24, Preferably, the single base smokeless explosive which consists of nitrocellulose 98 mass%, diphenylamine 0.8 mass%, and potassium sulfate 1.2 mass% is mentioned. It is also possible to use various gas generating agents that are used in gas generators for airbags and gas generators for seat belt pretensioners. In the gas generating agent 25, unlike the ignition powder, the predetermined gas generated during combustion contains a gas component even at room temperature. The gas generating agent 25 is not necessarily used, and the drive unit 2 may be configured by the igniter 22 and the piston 23.

  Next, the holding | maintenance part 3 accommodates the injection liquid 34 which is the injection target substance inject | poured with the syringe 70 in the inside. Specifically, a through hole (accommodating hole) is provided at the center of the holding portion 3 so as to be along the central axis of the housing 5 in a state where the holding portion 3 is loaded in the housing 5 as shown in FIG. ) 33 is formed. And in this through-hole 33, the injection liquid 34 is accommodated in the space between the upstream stopper 31 and the downstream stopper 32. FIG. The upstream stopper 31 and the downstream stopper 32 allow the injection liquid 34 to smoothly flow into the through-hole 33 as the piston 23 slides, as will be described later, so that the injection liquid does not leak when the injection liquid 34 is accommodated. It is made of rubber with a thin coating of silicone oil on its surface so that it can move. And the drive part 2 side edge part of the through-hole (accommodation hole) 33 obstruct | occluded with the upstream line 31 turns into an accommodation hole side edge part.

  Next, the nozzle part 4 has a flow path for injecting the injection liquid 34 accommodated in the holding part 3 to an injection target (injection target region) outside the syringe 70. Specifically, the nozzle portion 4 is formed with a nozzle 43 for injecting the injection solution 34, and the downstream stopper 32 in a state where the nozzle portion 4 is loaded in the housing 5 as shown in FIG. 1. A recessed portion 41 that can accommodate the downstream plug 32 is formed at a location facing the. The recess 41 has substantially the same diameter as the downstream plug 32 and has a depth slightly longer than the length of the downstream plug 32. As a result, the downstream stopper 32 can be accommodated in the recess 41 when pressure is applied to the injection solution 34 by the injection energy from the drive unit 2. When the downstream stopper 32 is accommodated in the recess 41, the pressurized injection solution 34 is released from the space in the through hole 33 of the holding unit 3. A flow path 42 for guiding the opened injection solution 34 to the nozzle 43 is provided so as to extend in a direction perpendicular to the central axis of the syringe 70. Thereby, the released injection solution 34 is ejected from the nozzle 43 to the injection target through the flow path 42. Moreover, it can avoid that the injection | pouring of the injection liquid 34 is inhibited by the downstream stopper 32 because the recessed part 41 has the depth which accommodates the downstream stopper 32. FIG.

  A plurality of nozzles 43 may be formed in the nozzle portion 4 or one nozzle 43 may be formed. When a plurality of nozzles 43 are formed, the flow paths 42 corresponding to the nozzles 43 are formed so that the injection solution released to the nozzles 43 is fed. Further, when a plurality of nozzles 43 are formed, it is preferable that the nozzles 43 are arranged at equal intervals around the central axis of the syringe 70. The diameter of the nozzle 43 is appropriately set in consideration of the injection target, the injection pressure applied to the injection liquid 34, the physical properties (viscosity) of the injection liquid, and the like.

As described above, in the syringe 70, the power supply unit 1, the drive unit 2, the holding unit 3, and the nozzle unit 4 are independently configured, and each component unit is mounted on the housing 5 as shown in FIG. By sequentially loading, the loading state shown in FIG. 1 is formed.

  In this way, by configuring the components of the syringe 70 independently of each other, the user can select the components according to the purpose of injection and combine them to assemble the final syringe 70. For example, a plurality of types of drive units 2 with different types and amounts of the gas generating agent 25 can be prepared so that the pressure profile applied to the injection solution 34 can be changed to adjust the injection depth of the injection target. . In addition, the type and amount of the injection liquid 34 to be injected onto the injection target can be adjusted according to the state of the injection target (for example, the case where the injection target is an adult skin structure and the skin of a child Preparation of multiple types of holding portions 3 with different types and amounts of injection solutions, so that the dose can be adjusted considering that the amount of injection solution to be administered is different from that of a structure. can do. In addition, a plurality of types of nozzle portions 4 having different numbers of nozzles 43, nozzle diameters, and the like can be prepared so that a suitable injection form of the injection solution 34 can be selected according to the injection target. Then, the user selects one drive unit 2, one holding unit 3, and one nozzle unit 4 in order to achieve a predetermined injection purpose performed by the user, and each configuration as shown in FIG. The part is loaded into the housing 5 through the loading opening 52 and the syringe 70 can be used. Thereby, injection | pouring of the injection solution according to various objectives is easily implement | achieved.

  In order to make it easy for the user to select one drive unit 2, one holding unit 3, and one nozzle unit 4 in order to prepare for injection with respect to the housing, each component unit has its outer shape. It is preferable to attach a predetermined unified paint or design. For example, the drive unit 2 is unified with blue paint, the holding unit 3 is unified with yellow paint, the nozzle unit 4 is unified with red paint, and the like. Thereby, user's mistakes, such as selecting the some drive part 2, can be suppressed.

  Incidentally, as shown in FIGS. 1 and 2, the power supply unit 1 is first loaded in the housing 5. When the power supply unit 1 is loaded into the housing 5 from the surface of the pushbutton switch 11, the stepped portion 13 provided around the pushbutton switch 11 is replaced with the stepped portion provided around the opening 53 of the housing 5. 54, the loading position of the power supply unit 1 is determined. In this loading position, the top surface of the pushbutton switch 11 and the end surface of the housing 5 on the opening 53 side are flush with each other.

  Here, in the syringe 70, the drive unit 2 receives the applied voltage from the power supply unit 1, burns the gas generating agent 25, pressurizes the injection solution 34 with the generated combustion gas, and pressurizes the injection. Since the liquid 34 is ejected from the nozzle 43 to the outside, the order of loading the components into the housing 5 is as shown in FIG. 2, after the power supply unit 1, the drive unit 2, the holding unit 3, and the nozzle unit. Must be 4. If it is loaded in the wrong order, the injection solution 34 cannot be ejected by the syringe 70.

  Therefore, in the syringe 70, in order for the loading order of the components to the housing 5 to be appropriate, in other words, if the user mistakes the loading order of the components, the user immediately A configuration for defining the loading position of each component in the housing 5 is adopted so that an error can be recognized. Specifically, the outer peripheral surface of each component is formed as a tapered surface (first tapered surface) so as to correspond to the tapered surface 50 (second tapered surface) which is the inner peripheral surface of the housing 5. As described above, with respect to the tapered surface 50, the radius (outer diameter) forming the tapered surface 50 increases from the upstream side toward the downstream side. Then, according to the order to be loaded into the housing 50 so as to correspond to the taper surface 50, in other words, in a state where the respective components are overlapped in the axial direction in the housing 5 as shown in FIG. Each component is formed so as to form a tapered surface (first tapered surface) in which the outer peripheral surfaces of the power source unit 1, the driving unit 2, the holding unit 3, and the nozzle unit 4 are continuous so as to correspond to the tapered surface 50 on the housing 5 side. The outer peripheral surfaces 10, 20, 30, 40 are formed.

  As described above, the outer peripheral surfaces 10, 20, 30, 40 of the respective components are formed so as to have a continuous tapered surface when they are overlapped, so that the syringe 70 can be used. 1, the loading position of each component is uniquely determined as shown in FIG. If the holding unit 3 is loaded into the housing 5 before the drive unit 2, the holding unit 3 is in a position where the outer peripheral surface 30 of the holding unit 3 and a part of the corresponding tapered surface 50 are in contact with each other, that is, holding. It is not possible to proceed deeper (upstream side) than the loading position where the unit 30 is to be loaded. Therefore, when the user tries to load the drive unit 2 thereafter, the drive unit 2 cannot be loaded, so that the user can quickly notice that the loading order is incorrect. Therefore, the taper surface 50 (second taper surface) of the housing 5 and the continuous taper surface (first taper surface) formed by overlapping the outer peripheral surfaces 10, 20, 30, and 40 of the respective components are provided in the present invention. Corresponds to the defining means.

  Then, as shown in FIG. 1, when each component is loaded into the housing 5, the fixing ring 6 is inserted into the housing 5 so as to come into contact with the end face of the nozzle portion 4 located on the most downstream side. The fixing ring 6 has a male screw cut on the outer periphery thereof, and is screwed with a female screw portion 51 provided in the vicinity of the end portion (loading opening 52) of the inner peripheral surface of the housing 5. Thereby, each component loaded in the housing 5 can be pressed and fixed via the nozzle portion 4.

<Modification 1>
In the above-described embodiment, the power supply unit 1 is also loaded into the housing 5 through the loading opening 52 together with the other components. However, instead of the form, as shown in FIG. Alternatively, the power supply unit 1 may be loaded from the upstream side with respect to the housing 5. At this time, the stepped portion 14 is provided around the end surface opposite to the end surface where the push button switch 11 of the power supply unit 1 is provided. A recess 55 for accommodating the power supply unit 1 is provided on the opening 53 side of the housing 5, and protrudes into a space connecting the recess 55 and the space in the housing 5 defined by the tapered surface 50. A portion 56 is provided. When the power supply unit 1 is loaded in the recess 55, the stepped portion 14 on the power supply unit 1 side is abutted against the protrusion 56 on the housing 5 side, so that the loading position of the power supply unit 1 is determined. The loaded power supply unit 1 is fixed to the housing 5 by a known fixing means or the like (for example, in a state where the power supply unit 1 has a snap fit or the like and is detachable from the housing). When the power supply unit 1 is loaded in the housing 5 as described above, the power supply unit side electrode 12 is exposed toward the space in the housing 5 defined by the tapered surface 50, as in FIG. Then, the drive unit 2 can be brought into contact with the drive unit side electrode 21 of the drive unit 2 loaded through the loading opening 52.

  The power supply unit 1 can execute power supply to the drive unit 2 several times depending on the storage capacity. In such a case, as shown in FIG. 1, as with other components such as the drive unit 2, it may be troublesome to load the power supply unit 1 into the housing 5 each time the injection solution 34 is injected. is there. Therefore, as shown in FIG. 3, only the power supply unit 1 is loaded separately from the other components, in other words, the power supply unit 1 is not subject to the regulation of the loading position by the tapered surfaces described above. Thereby, the troublesomeness regarding the loading of the power supply unit 1 can be reduced. It should be noted that after supplying power a predetermined number of times according to the storage capacity of the power supply unit 1, the power supply unit 1 may be removed from the housing and a new power supply unit 1 may be loaded.

<Modification 2>
FIG. 4 shows a relative relationship between the drive unit 2 and the holding unit 3 according to this modification. A gas generating agent 25 is disposed in the combustion chamber 24. The gas generating agent 25 is combusted by ignition of the igniter 22, and the piston 23 is pressed by the combustion gas. At this time, the piston 23 moves from the opening part (driving part side opening part) 24a on the driving part 3 side of the combustion chamber 24 to the holding part 3 side. On the other hand, on the holding portion 3 side, the piston 23 enters through the end portion (receiving hole side end portion) 33a of the through hole 33 in which the upstream plug 31, the injection solution 34, and the downstream plug 32 are arranged. The injection energy of the gas generating agent 25 from the combustion gas is transmitted to the injection solution 34 via the upstream plug 31.

  Here, an annular protrusion 26 is provided on the end surface of the drive unit 2 on the holding unit 3 side so as to surround the opening 24a. The annular protrusion 26 is formed of a relatively soft metal such as aluminum. When each component is loaded into the housing 5 and fixed by the fixing ring 6 as shown in FIG. With such a pressing force, the drive unit 2 and the holding unit 3 are crushed and deformed. Note that this deformation does not hinder the transmission of injection energy from the piston 23 to the upstream plug 31. As a result, the deformed annular projecting portion 26 is sealed so as to surround the space between the driving portion 2 and the holding portion 3 with the combustion chamber 24 and the through hole 33 as the center. Can be prevented from leaking out from between the drive unit 2 and the holding unit 3, so that effective injection energy can be transmitted to the injection solution 34.

<Modification 3>
FIG. 5 shows a relative relationship between the drive unit 2 and the holding unit 3 according to this modification. In FIG. 5, instead of the annular protrusion 26 shown in FIG. 4, an annular protrusion 27 and an annular groove 28 are provided so that effective injection energy can be transmitted to the injection solution 34 in the same manner. The structure to perform is disclosed. Specifically, an annular protrusion 27 is provided on the end surface of the driving unit 2 on the holding unit 3 side so as to surround the opening 24a. Unlike the annular protrusion 26, the annular protrusion 27 is not deformed when fixed on the housing 5, and is provided so as to surround the end 33a on the end face of the holding part 3 on the drive part 2 side. The annular groove 28 is fitted. The depth of the annular groove 28 is set slightly deeper than the height of the annular protrusion 27.

  As a result, the fitting between the annular protrusion 27 and the annular groove 28 seals the space between the drive unit 2 and the holding unit 3 around the combustion chamber 24 and the through hole 33. Become. Therefore, it is possible to suppress the combustion gas of the gas generating agent 25 from leaking out from between the drive unit 2 and the holding unit 3, thereby effectively transmitting the injection energy to the injection solution 34. be able to.

  Based on FIG. 6, the second embodiment of the syringe 70 will be described, in particular, the defining means for defining the loading position of each component loaded in the housing 5. In addition, in the syringe 70 according to the second embodiment, the configuration other than the defining means is the same as that of the syringe 70 according to the first embodiment. Therefore, the same reference numerals are assigned to the same configuration. Thus, detailed description thereof is omitted.

  In this embodiment, the power supply unit 1, the drive unit 2, the holding unit 3, and the nozzle unit 4 loaded in the housing 5 are formed in a substantially cylindrical shape, and the radii (outer diameters) of the outer peripheral surfaces of the respective components are set. The outer peripheral surface 100 of the power supply unit 1, the outer peripheral surface 200 of the driving unit 2, the outer peripheral surface 300 of the holding unit 3, and the outer peripheral surface 400 of the nozzle unit 4 are designed to increase in this order. Therefore, in the case of the present embodiment, when the respective constituent portions are overlapped in the housing 5, the outer peripheral surface of each constituent portion does not form a continuous tapered surface as in the first embodiment, but is stepped. A discontinuous outer peripheral surface is formed. The inner peripheral surface on the housing 5 side is formed corresponding to the outer peripheral surface of each component. Specifically, an inner peripheral surface 501 is provided corresponding to the outer peripheral surface 100 of the power supply unit 1, an inner peripheral surface 502 is provided corresponding to the outer peripheral surface 200 of the drive unit 2, and the outer peripheral surface 300 of the holding unit 3. Corresponding to the inner peripheral surface 503, and the inner peripheral surface 504 is provided corresponding to the outer peripheral surface 400 of the nozzle portion 4. Then, the respective radii (inner diameters) are set larger in the order of the inner peripheral surfaces 501, 502, 503, and 504. Therefore, the inner peripheral surface of the housing 5 is also formed as a stepped discontinuous surface.

  As described above, the outer peripheral surfaces 100, 200, 300, and 400 of the respective components are formed so as to be stepped discontinuous outer peripheral surfaces when they are overlapped, and the inner peripheral surface of the housing 5 is the outer peripheral surface. In order to make the syringe 70 ready for use by being formed to correspond, the loading position of each component in the housing 5 is uniquely determined as shown in FIG. . For this reason, if the user makes a mistake in the loading order, the user can quickly notice it. Therefore, the stepped inner peripheral surfaces 501, 502, 503, and 504 on the housing 5 side and the stepped outer peripheral surfaces formed by overlapping the outer peripheral surfaces 100, 200, 300, and 400 of the respective components are provided in the present invention. Corresponds to the defining means.

  Further, the outer shape of each component may be a truncated cone shape so that the outer peripheral surface becomes a tapered surface instead of the above-described columnar shape.

<Other examples>
According to the syringe 70 according to the present invention, in addition to the case where the above-mentioned injection solution is injected into the skin structure, for example, in the field of regenerative medicine for humans, the cells to be injected and the cultured cells in the scaffold tissue / scaffold It is possible to seed stem cells and the like. For example, as disclosed in JP-A-2008-206477, cells that can be appropriately determined by those skilled in the art depending on the site to be transplanted and the purpose of recellularization, such as endothelial cells, endothelial precursor cells, bone marrow cells, and prebones Blast cells, chondrocytes, fibroblasts, skin cells, muscle cells, liver cells, kidney cells, intestinal cells, stem cells, and any other cells considered in the field of regenerative medicine can be injected by the syringe 70. . More specifically, the liquid (cell suspension) containing the cells to be seeded is accommodated in the holding unit 3 and pressurized by the combustion of the gas generating agent 25 to thereby give a predetermined site to the transplanted site. Cells are injected and transplanted.

  Furthermore, the syringe 70 according to the present invention can also be used for delivery of DNA or the like to cells, scaffold tissue, scaffolds, etc. as described in JP-T-2007-525192. In this case, it can be said that the use of the syringe 70 according to the present invention is more preferable than the case where delivery is performed using a needle because the influence on the cells, the scaffold tissue, the scaffold, and the like can be suppressed.

  Furthermore, the syringe 70 according to the present invention is suitable also when various genes, tumor suppressor cells, lipid envelopes, etc. are directly delivered to a target tissue or when an antigen gene is administered to enhance immunity against a pathogen. Used for. In addition, in the field of various disease treatments (fields described in JP2008-508881, JP2010-503616, etc.), immunomedicine (fields described in JP2005-523679, etc.), etc. The syringe 70 can be used, and the field in which the syringe 70 can be used is not intentionally limited.

DESCRIPTION OF SYMBOLS 1 ... Power supply part 2 ... Drive part 3 ... Holding part 4 ... Nozzle part 5 ... Housing 6 ... Fixing ring 10, 20, 30, 40 ... · · · Outer peripheral surface 12 ··· Power source side electrode 21 · · · Drive side electrode 22 · · · igniter 23 · · · piston 24 · · · combustion chamber
24a ... opening 25 ... gas generating agent 26 ... annular protrusion 31 ... upstream plug 32 ... downstream plug 33 ... through hole 33a ... End 34... Injection solution 41... Recess 43... Nozzle 70... Syringe 100, 200, 300, 400 ・ ・ ・ Outer peripheral surface 501, 502, 503, 504.・ Inner surface

Claims (5)

A syringe for injecting a target substance into an injection target region of a living body,
A housing having a loading opening on the downstream side determined based on the injection direction of the injection target substance ;
A holding part for containing the injection target substance
A drive unit that applies energy for injection from the holding unit to the injectable substance contained in the holding unit;
A nozzle part including a flow path through which the injection target substance injected from the holding part flows, and for injecting the injection target substance from the opening end of the flow path to the injection target region;
A power supply unit that supplies power to the drive unit,
The holding part, the driving part, the nozzle part, and the power supply part are independently loaded with respect to the housing, and the power supply part, the driving part, and the like through the loading opening of the housing. The state in which the injection target substance can be injected is formed by being loaded in the order of the holding portion ,
The driving unit includes an explosive or a gas generating agent combusted by an applied voltage from the power supply unit, and is injected into the injection target substance through a pressure of a combustion gas generated by the combustion of the explosive or the gas generating agent. Give energy,
Furthermore, the holding with respect to the housing is formed such that a loading state in which the holding unit, the driving unit , and the power supply unit are always loaded in the same arrangement in the housing for injection of the injection target substance is formed. A regulating means for regulating the loading position of the power supply unit ,
The power supply unit is positioned at a predetermined loading position on the upstream side of the housing based on the injection direction of the injection target substance .
Syringe. A syringe for injecting a target substance into an injection target region of a living body,
A housing having a loading opening on the downstream side determined based on the injection direction of the injection target substance ;
A holding part for containing the injection target substance
A drive unit that applies energy for injection from the holding unit to the injectable substance contained in the holding unit;
A nozzle part including a flow path through which the injection target substance injected from the holding part flows, and for injecting the injection target substance from the opening end of the flow path to the injection target region;
A power supply unit that supplies power to the drive unit,
The holding unit, the driving unit, the nozzle unit, and the power supply unit are loaded independently with respect to the housing, and the driving unit and the holding unit are connected to each other through the loading opening of the housing. The state in which the injection target substance can be injected is formed by being sequentially loaded in the inside ,
The driving unit includes an explosive or a gas generating agent combusted by an applied voltage from the power supply unit, and is injected into the injection target substance through a pressure of a combustion gas generated by the combustion of the explosive or the gas generating agent. Give energy,
The holding portion and the driving portion of the housing with respect to the housing are formed so that a loading state in which the holding portion and the driving portion are always loaded in the same row in the housing for injection of the injection target substance is formed. Defining means for defining the loading position;
Means for positioning the power supply unit at a predetermined loading position on the upstream side of the housing based on the injection direction of the injection target substance separately from the holding unit and the driving unit;
A syringe. The power supply unit includes a power supply side first electrode located on a central axis of the housing, and a power supply side second electrode separated from the power supply side first electrode by a predetermined distance,
The drive unit is an electrode corresponding to the power supply side first electrode and the power supply side second electrode, the drive side first electrode located on the central axis of the housing, and the drive side first electrode as a center And a driving-side second electrode formed in a circumferential shape having the same radius as the predetermined distance,
The syringe according to claim 1 or claim 2 . The drive unit has a drive unit side opening which is an opening for applying the emission energy to the holding unit side,
The holding portion has a receiving hole for storing the injection target substance, and the receiving hole has a receiving hole side end portion that receives the emission energy applied from the driving portion side opening,
An annular projection that surrounds the drive-side opening or the accommodation hole-side end, and the annular projection is deformed in the loaded state, so that the drive-side opening and the accommodation hole-side end An annular protrusion that seals the space between the drive unit and the drive unit or the holding unit is provided,
The syringe according to any one of claims 1 to 3 . The drive unit has a drive unit side opening which is an opening for applying the emission energy to the holding unit side,
The holding portion has a receiving hole for storing the injection target substance, and the receiving hole has a receiving hole side end portion that receives the emission energy applied from the driving portion side opening,
An annular projection that surrounds the drive unit side opening or the accommodation hole side end is provided on either the drive unit side or the holding unit side,
An annular groove surrounding the drive part side opening or the accommodation hole side end, and the annular projection fits in the loaded state, so that the drive part side opening and the accommodation hole side end An annular groove that seals the space between the drive unit and the other of the drive unit or the holding unit is provided.
The syringe according to any one of claims 1 to 3 .

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