JP6741433B2 - Emulsion composition for disinfection - Google Patents

Description

The present invention belongs to a disinfectant used for sterilization of fingers and the like, and is a semisolid high-viscosity disinfectant having excellent emulsion stability even though a lower alcohol having 1 to 3 carbon atoms is blended at a high ratio. Emulsion composition for use.

Conventionally, it is generally known that lower alcohols having 1 to 3 carbon atoms such as ethanol and isopropyl alcohol have a disinfecting action on bacteria and viruses due to destruction of cell membranes of bacteria and envelopes of viruses and coagulation of proteins such as enzymes. , Disinfectants containing these lower alcohols are widely used. However, since disinfectants containing lower alcohols such as ethanol and isopropyl alcohol are generally in a liquid state, when used for disinfecting fingers, for example, if the disinfectant is taken out from the container storing it into the palm and leaks from the palm. There were problems such as dripping and wasting out the disinfectant more than necessary. Therefore, a semi-solid preparation having high fluidity such as a gel has been developed, but since it is necessary to add a high concentration of lower alcohol to obtain a disinfecting action, there is a problem of causing rough hands. .. For these reasons, there is a demand for a creamy disinfectant capable of preventing rough hands even when a lower alcohol is mixed in a high concentration.

For example, Patent Document 1 discloses a creamy composition for external use, such as scalp, which contains ethanol in an amount of less than 10% by weight and a thickener such as carboxyvinyl polymer.

JP, 2014-94933, A

However, in the invention described in Patent Document 1, as shown in paragraph 0013 of the specification, Comparative Examples 6 to 8 and Table 6, even if a thickener is blended, if ethanol is blended in an amount of 10% by weight or more, There was a problem that the cream was separated and was not stable.

Therefore, in the present invention, belonging to a disinfectant used for sterilization of fingers and the like, even though a lower alcohol having 1 to 3 carbon atoms is blended at a high ratio, it also has excellent emulsion stability and can prevent rough hands when used. It is an object of the present invention to provide a semi-solid, high-viscosity, disinfecting emulsion composition.

(1) That is, the present invention comprises 20 to 50% by weight of a lower alcohol having 1 to 3 carbon atoms, 0.1 to 10% by weight of a thickener which is at least one selected from a carboxyvinyl polymer and a cellulose derivative . And containing a surfactant having a polyoxyethylene alkyl ether and a fatty acid ester of a polyhydric alcohol, having a viscosity of 50 to 300 Pa·s at 25° C. after preparation and 25° C. after being stored at 50° C. for 60 days. The viscosity is 75% to 101% of the viscosity at 25° C. after the preparation, and the emulsion composition for disinfection.

[ 2 ] The disinfecting emulsion composition according to the above [1], which contains at least one disinfecting component selected from benzethonium chloride, benzalkonium chloride, and chlorhexidine gluconate.

ADVANTAGE OF THE INVENTION According to this invention, while being mix|blended with a high ratio of C1-C3 lower alcohol, it is excellent in emulsification stability and is a semi-solid high viscosity disinfection which can also prevent rough hands when used. An emulsified composition can be formed.

Hereinafter, embodiments of the emulsifying composition for disinfection of the present invention will be described in detail. In addition, when there is a notation indicating a range in the description, the upper limit and the lower limit are included.

The lower alcohol having 1 to 3 carbon atoms in the present invention is an alcohol having 1 to 3 carbon atoms such as methanol, ethanol and isopropyl alcohol. By using the lower alcohol, the bacteria and viruses can be killed by the destruction of bacterial cell membranes and viral envelopes and the coagulation of proteins such as enzymes, and the adverse effects on the human body such as diseases caused by these bacteria and viruses can be prevented. ..

The content ratio of the lower alcohol having 1 to 3 carbon atoms in the emulsion composition for disinfection is preferably 20 to 50% by weight. When the content ratio exceeds 50% by weight, when the emulsion composition for disinfection is manufactured by mixing with other components, it is separated and the viscosity is remarkably lowered, and the properties of the cream cannot be maintained. If the content is less than 20% by weight, bacteria and viruses cannot be sterilized sufficiently, and it is necessary to add other bactericidal components or the like in order to exert the desired effect.

The fats and oils in the present invention are fats and oils that are liquid or solid at room temperature of 20°C to 25°C. When the emulsified composition for disinfection is used by emulsifying the oil and fat, the oil and fat can be prevented from spreading to the skin such as fingers and volatilizing water from the skin, thereby preventing rough hands. As the oil and fat, both natural products and synthetic products can be used, and as the natural product, both plant-derived and animal-derived oils and fats can be used.

Examples of fats and oils include liquid paraffin, light liquid paraffin, hydrocarbons such as squalane, isopropyl palmitate, octyl palmitate, isopropyl myristate, isononyl isononanoate, and medium-chain fatty acids having 8 to 22 carbon atoms. Triglycerides, ester oils such as glyceryl tri(capryl/capric acid), myristyl alcohol (14 carbon atoms), cetanol (16 carbon atoms), stearyl alcohol (18 carbon atoms), cetostearyl alcohol (mixture of 16 and 18 carbon atoms) , Saturated monohydric alcohols such as behenyl alcohol (carbon number 22), isostearyl alcohol (carbon number 18), 2-hexyldecanol (carbon number 16), 2-octyldodecanol (carbon number 20), and oleyl alcohol (carbon number). 18) and other aliphatic alcohols such as unsaturated monohydric alcohols, soybean oil, safflower oil, grape seed oil, rosehip oil, sunflower oil, evening primrose seed oil, cottonseed oil, sesame oil, wheat germ oil, almond oil, etc. , Non-drying oils include olive oil, southern oil, camellia oil, castor oil, peanut oil, avocado oil, macadamia nut oil, hazelnut oil, meadowfoam oil, jojoba oil, and essential oils such as eucalyptus oil, light oil, and Roman Chamomile oil and the like (vegetable oil) are preferred. These oils and fats can be used alone or in combination of two or more.

The content of the oil and fat in the disinfecting emulsion composition is preferably 0.5 to 20% by weight, and more preferably 1.0 to 10% by weight. When the content ratio is within the above range, it is possible to prevent the user's hands from becoming rough when used.

The thickener in the present invention is a component that increases the viscosity of the disinfecting emulsion composition. By using a thickener, the viscosity of the disinfecting emulsion composition can be increased to a predetermined value.

Examples of the thickener include a carboxyvinyl polymer that is a cross-linked polyacrylic acid, a cellulose derivative such as carboxymethyl cellulose, hydroxyethyl cellulose, and hydroxypropyl cellulose, xanthan gum, guar gum, gum arabic, sodium alginate, propylene glycol alginate, and ethyl cellulose. , Sodium polyacrylate, cyclodextrin and the like are preferable, and among them, carboxyvinyl polymer and carboxymethyl cellulose are more preferable. These thickeners can be used alone or in combination of two or more.

The content ratio of the thickener in the disinfecting emulsion composition is preferably 0.1 to 10% by weight, more preferably 0.2 to 7% by weight. When the content ratio is within the above range, it is possible to adjust to a desired viscosity suitable for use.

The surfactant in the present invention is a component for uniformly mixing the emulsion composition for disinfection and stabilizing the creamy property. By using the surfactant, it is possible to prevent the lower alcohol having 1 to 3 carbon atoms, which is a component of the disinfecting emulsion composition, from being separated.

Examples of surfactants include cationic surfactants, anionic surfactants, amphoteric surfactants, and nonionic surfactants. The cationic surfactant is a surfactant which becomes a cation when dissociated in water, and for example, an alkyltrimethylammonium salt, an alkyldimethylammonium salt, an alkylbenzyldimethylammonium salt and the like are preferable. Of these, the alkyl group preferably has 12 to 22 carbon atoms, and the counter anion is preferably a chloride ion, a hydroxide ion, a bromide ion, or the like.

The anionic surfactant is a surfactant that becomes an anion when dissociated in water, and examples thereof include fatty acid salts, monoalkyl sulfates, alkyl polyoxyethylene sulfates, alkylbenzene sulfonates, and monoalkyl phosphates. Salt and the like are preferable. Of these, the alkyl group preferably has 12 to 22 carbon atoms, and the counter cation is preferably sodium ion, potassium ion, calcium ion, magnesium ion or the like.

The amphoteric surfactant has both an anionic site and a cationic site in the molecule, and is a surfactant that becomes a cation, an anion, and both a cation and an anion depending on the pH of the solution. And, for example, alkyldimethylamine oxide and alkylcarboxybetaine are preferable. Of these, the alkyl group preferably has 12 to 22 carbon atoms.

Then, the nonionic surfactant is an active agent having a hydrophilic part in which the hydrophilic part is not ionized, and for example, polyoxyethylene alkyl ether such as polyoxyethylene cetyl ether or polyoxyethylene stearyl ether, glycerin fatty acid ester or sorbitan. Polyhydric alcohol fatty acid ester such as fatty acid ester and sucrose fatty acid ester, fatty acid ester of polyoxyethylene-added polyhydric alcohol, fatty acid diethanolamide and the like are preferable. Among the above nonionic surfactants, those having an HLB of 3 to 17 calculated from Griffin's formula are more preferable. For the nonionic surfactant having a polyoxyethylene skeleton, the number of moles of oxyethylene added can be appropriately changed. When the HLB is a nonionic surfactant in the above range, the emulsion composition for disinfection is excellent in storage stability, and specifically, it does not cause separation or the like even after a lapse of time and can maintain a creamy state. These surfactants can be used alone or in combination of two or more, but it is preferable to combine the surfactants of HLB 3 to 6 and the surfactants of HLB 12 to 17.

Further, it is preferable that water is blended in the disinfecting emulsion composition of the present invention. The water is preferably Japanese Pharmacopoeia standard water, for example, tap water, well water such as well water, and either distillation, ion exchange treatment with an ion exchange membrane, ultrafiltration treatment with an ultrafiltration membrane, Alternatively, purified water obtained by treating ordinary water with a combination thereof and sterilized purified water obtained by sterilizing the purified water by heating or the like are preferable. The mixing ratio of water is the balance excluding ethanol, thickener, surfactant, etc. used in the present invention, preferably 40 to 80% by weight, and preferably 42 to 75% by weight. preferable.

In addition, the disinfecting emulsion composition of the present invention may contain a disinfecting component, if necessary. The disinfectant component is added for disinfecting bacteria or viruses that cannot be sufficiently disinfected with a lower alcohol having 1 to 3 carbon atoms. As the disinfecting component, for example, benzethonium chloride, benzalkonium chloride, chlorhexidine gluconate and the like are preferable, and benzethonium chloride is more preferable. Further, these disinfecting components can be used alone or in combination of two or more.

In the disinfecting emulsion composition of the present invention, the viscosity can be improved by blending a thickener, and the viscosity of the disinfecting emulsion composition of the present invention is the Brookfield rotational viscosity described in JIS K7117-1. In measurement using a total type B (trade name “TVB-10M” manufactured by Toki Sangyo Co., Ltd.), it is preferably 50 to 300 Pa·s, and more preferably 100 to 250 Pa·s at 25° C. preferable. When the viscosity of the emulsifying composition for disinfection is within this range, it does not run off immediately even if it adheres to the skin such as fingers, and is easy to spread when spreading.

It is preferable to further add a moisturizer to the emulsion composition for disinfection of the present invention. Examples of the moisturizing agent include polyhydric alcohols such as glycerin, polyglycerin, propylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 1,2-hexanediol, polyethylene glycol, maltitol and sorbitol, hyaluronic acid. Sodium acid, urea, sodium lactate, trimethylglycine and the like are preferable.

In addition to the above components, the disinfecting emulsion composition of the present invention may optionally contain an antioxidant such as tocopherol, vitamin C or BHT, a pH adjusting agent, a buffer, a fragrance, or a dye. it can.

[Example 1]
50 parts by weight of ethanol, 0.5 parts by weight of carboxyvinyl polymer (Wako Pure Chemical Industries, Ltd., trade name: "Hibiswako 103") which is a thickener, and polyoxyethylene cetyl which is a nonionic surfactant. 2 parts by weight of ether (manufactured by Nikko Chemicals Co., Ltd., product name: “NIKKOL BC-15”, HLB: 15.5), glycerin monostearate (manufactured by Nikko Chemicals Co., Ltd., product name: nonionic surfactant) 2 parts by weight of "NIKKOL MGS-AMV", HLB:4.0), 1 part by weight of liquid paraffin (manufactured by Chuo Kasei Co., Ltd., product name: "liquid paraffin 350S") which is an oil and fat, myristin which is an oil and fat. 1 part by weight of isopropyl acid, 0.5 part by weight of stearyl alcohol which is an oil and fat, 0.5 part by weight of glycerin which is a moisturizing agent, dimethylpolysiloxane (manufactured by Toray Dow Corning Co., Ltd., trade name: "Q7- 9120 SILICONE FLUID350CST”), 0.5 parts by weight, benzethonium chloride as an antiseptic component, 0.05 parts by weight, sodium hydroxide, 0.06 parts by weight, and 100 parts by weight of the balance as water. The mixture was mixed well until

Then, the obtained emulsified composition for disinfection was adjusted to be 25° C., and its viscosity was measured by using the B-type rotational viscometer. It was 160 Pa·s when measured with a rotor of No. 23.

When visually evaluating the properties of the emulsion composition for disinfection immediately after production, as a criterion for evaluation, a good state in which there is a creamy viscosity and is not separated is evaluated as “○”, and some transparency remains. An approximately good condition without the evaluation was evaluated as “Δ”, and an unfavorable condition in which the viscosity was extremely low due to separation was evaluated as “x”. Further, when visually evaluating the properties of the emulsified disinfectant composition prepared for observing the stability over time after standing for 60 days in a constant temperature bath at 50° C., the evaluation criteria are unchanged from immediately after preparation. The poor state was evaluated as “◯”, and the poor state in which separated or precipitate was observed was evaluated as “x”.

When evaluated according to the above-described evaluation criteria, the properties of the emulsified emulsion composition immediately after the preparation of this example were good, although they remained transparent without separation, and were evaluated as “Δ”. The property of the prepared disinfecting emulsified composition after standing for 60 days in a constant temperature bath of 50° C. was good without any change as compared with immediately after preparation, and thus was evaluated as “◯”.

Further, the viscosity of the emulsifying composition for disinfection after standing for 60 days in a constant temperature bath at 50° C. was 120 Pa·s when measured in the same manner as after the production as described above, and the creamy emulsifying composition was obtained. As a result, a sufficient viscosity was maintained.

[Example 2]
A disinfecting emulsion composition was prepared in the same manner as in Example 1 except that 40 parts by weight of ethanol was used. Then, when the viscosity was measured in the same manner as in Example 1, it was 183 Pa·s.

The properties of the emulsion composition for disinfection immediately after preparation in this example were in a good state in which it had a creamy viscosity and did not separate, and was evaluated as “◯”. Moreover, the properties of the emulsified emulsion composition after storage at 50° C. were in good condition, which was the same as immediately after preparation, and were evaluated as “◯”.

Also, as in Example 1, the viscosity of the emulsifying composition for disinfection after standing for 60 days in a constant temperature bath of 50° C. was measured and found to be 150 Pa·s, which was a sufficient viscosity as a creamy emulsifying composition. Was holding.

[Example 3]
A disinfecting emulsion composition was prepared in the same manner as in Example 1 except that ethanol was changed to 30 parts by weight in Example 1. Then, the viscosity was measured in the same manner as in Example 1 and found to be 211 Pa·s.

The properties of the emulsion composition for disinfection immediately after preparation in this example were in a good state in which it had a creamy viscosity and did not separate, and was evaluated as “◯”. Moreover, the properties of the emulsified emulsion composition after storage at 50° C. were in good condition, which was the same as immediately after preparation, and were evaluated as “◯”.

Further, as in Example 1, the viscosity of the emulsifying composition for disinfection after standing for 60 days in a constant temperature bath at 50° C. was measured to be 214 Pa·s, which is a sufficient viscosity as a creamy emulsifying composition. Was holding.

[Comparative Example 1]
A disinfecting emulsion composition was prepared in the same manner as in Example 1 except that 54 parts by weight of ethanol was used. Then, when the viscosity was measured in the same manner as in Example 1, it was 30 Pa·s.

The properties of the emulsion composition for disinfection immediately after the preparation of this example were "B" because they were almost good properties although they remained transparent without separation. The property of the emulsified composition for disinfection after storage at 50° C. was a state in which separation was observed and was “x” evaluation.

The results of Examples 1 to 3 and Comparative Example 1 described above are summarized in Table 1.

From Table 1, the properties of the emulsion composition for disinfection during preparation and after standing still under predetermined temperature conditions by adjusting the content ratio of ethanol in the compounding system of ethanol, thickener and surfactant It was found that both of them can stably retain the creamy property.

Further, in order to confirm the effect of preventing rough hands, a moisture retention test was conducted using the disinfecting emulsion composition of Example 3. Specifically, the moisturizing test was carried out by a test method which is a general method as a performance test for cosmetics and the like. That is, in a room temperature of 15 to 25° C. and a humidity of 55 to 65%, a predetermined amount of the emulsifying composition for disinfection in Example 3 was applied to the inside of the forearm of the subject, and the epidermal stratum corneum water content measuring device (manufactured by Yayoi Co., Ltd.). , Trade name "SUKICON-200EX"), before application, and after 5 minutes, 30 minutes, 60 minutes, 120 minutes, 180 minutes and 240 minutes after application, the conductivity (μS /Cm) was measured. The results are shown in Table 2.

From Table 2, immediately after the application of the disinfecting emulsion composition in Example 3, the conductivity increases due to the water content in the disinfecting emulsion composition, and the conductivity decreases with the decrease due to volatilization of the water thereafter. However, the degree of decrease is gradual and is higher than the value immediately before application even after 240 minutes. Therefore, the disinfecting emulsified composition of Example 3 contains oil and fat. It was found that the moisturizing property was maintained for a long time.

Claims (2)

20-50% by weight of a lower alcohol having 1 to 3 carbon atoms, an oil and fat from 0.5 to 20 wt%, 0.1 carboxymethyl polymer, the thickener is at least one selected from cellulose derivatives 10 wt%, and contains a surfactant having a polyoxyethylene alkyl ether and fatty acid esters of polyhydric alcohol, a viscosity at 25 ° C. after manufacturing is 50~300Pa · s, stored 60 days at 50 ° C. The emulsion composition for disinfection, wherein the viscosity at 25° C. after the production is 75% to 101% of the viscosity at 25° C. after the production. The disinfecting emulsion composition according to claim 1, which comprises at least one disinfecting component selected from benzethonium chloride, benzalkonium chloride, and chlorhexidine gluconate .