JP7663758B1 - Oral Composition - Google Patents

Abstract

To provide an oral composition that has an excellent balance between ease of squeezing out of a tube container and sharpness.
[Solution] An oral composition comprising an abrasive and a binder, the oral composition having a tensile return force TF5 in a 5 mm tensile test measured using a rheometer of 10 gf or more and 50 gf or less, a spinnability measured using the rheometer of 24 mm or more and 50 mm or less, and a viscosity measured using a B-type viscometer of 100 Pa·s or less.
[Selection diagram] None

Description

The present invention relates to an oral composition.

Patent Document 1 (JP Patent Publication No. 2021-91654) describes a technique for improving the ease of application of an oral composition to a toothbrush. The document describes a dentifrice composition containing one or more water-soluble polyvalent metal salts selected from water-soluble aluminum salts, water-soluble copper salts, and water-soluble zinc salts, xanthan gum, and a cationic polymer compound (claim 1). According to the document, a dentifrice composition can be provided that has the effects of suppressing hypersensitivity, suppressing bad breath, tightening gums, etc. due to the water-soluble polyvalent metal salt, and is easy to apply to a toothbrush because of its excellent moldability, and is inhibited from hardening over time, making it easy to discharge from a container even after storage. This dentifrice composition can be formulated into a dentifrice composition that satisfactorily maintains the physical properties of the dentifrice composition, and that has a relatively small amount of abrasive or is free of abrasives, ensuring a gentle brushing experience with low irritation, and is particularly useful for suppressing hypersensitivity or bad breath and tightening gums (paragraph 0011).

JP 2021-91654 A

As a result of the inventors' investigations, it became clear that there is still room for improvement in the composition described in the above-mentioned Patent Document 1 in terms of improving the ease of use when squeezing the composition filled in the tube container from the tube container, specifically, in terms of making it easier to squeeze and sharper.

The present invention provides an oral composition that has an excellent balance between ease of squeezing from a tube container and sharpness.

According to the present invention, the following oral compositions are provided.
[1] An oral composition comprising an abrasive and a binder,
The tensile return force TF5 in a 5 mm tensile test measured by the following method 1 is 10 gf or more and 50 gf or less,
The spinnability measured by the following method 2 is 24 mm or more and 50 mm or less,
An oral composition having a viscosity of 100 Pa·s or less as measured by the following method 3.
(Method 1)
Name of equipment: Rheometer Jig used: Pressure-sensitive shaft for pressure/elasticity measurement (Φ20 mm)
Measurement speed: 60mm/min
Pulling distance: 5mm
Filling container: 30mL plastic jar (diameter 43mm)
Procedure: The filling container is filled to the brim with the oral composition, and after setting it in the device, it is pulled up at the measurement speed, and the absolute value of the stress at the time when the pulling distance is reached is measured. The average value of three measurements is defined as the TF5.
(Method 2)
Name of equipment: Rheometer Jig used: Pressure-sensitive shaft for measuring penetration (Φ15 mm)
Measurement speed: 1000mm/min
Pulling distance: 50 mm
Filling container: 30mL plastic jar (diameter 43mm)
Procedure: The oral composition is filled into the filling container until it is fully filled, and then the container is set in the device and then pulled up at the measurement speed. The distance until the oral composition separates from the jig during pulling is measured. The average value of the distance that is measured three times is regarded as the spinnability.
(Method 3)
Equipment name: B-type viscometer, rotor No. 4
Measurement speed: 12 rpm, 5M range Measurement time: 60 seconds Filling container: 19 mL vial (diameter 27 mm)
Procedure: The oral composition is filled into the filling container until it is fully filled, and after setting it in the instrument, the viscosity is measured at the measurement speed and for the measurement time.
[2] The oral composition according to [1], wherein the binder contains thickening silica.
[3] The oral composition according to [1] or [2], wherein the binder comprises an organic binder.
[4] The oral composition according to [3], wherein the organic binder is one or more selected from the group consisting of carboxymethylcellulose and its salts, xanthan gum, alginic acid and its salts, polyacrylic acid and its salts, carboxyvinyl polymers, hydroxyethylcellulose, hydroxypropylcellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, and carrageenan (excluding κ-carrageenan).
[5] The oral composition according to any one of [1] to [4], wherein the abrasive comprises abrasive silica.
[6] The oral composition according to any one of [1] to [5], further comprising a humectant.
[7] The oral composition described in any one of [1] to [6], which is a dentifrice composition.
[8] The oral composition according to any one of [1] to [7], which is a toothpaste composition.
[9] A dentifrice comprising the oral composition according to any one of [1] to [8] filled in a tube container.

In addition, any combination of these configurations, or conversions of the present invention between methods, devices, etc., are also valid aspects of the present invention.

The present invention makes it possible to obtain an oral composition that has an excellent balance between ease of squeezing from a tube container and sharpness.

Hereinafter, an embodiment of the present invention will be described. In the embodiment, the composition may contain each component alone or in combination of two or more kinds.
In this specification, the term "to" indicating a numerical range means "greater than or equal to" or "less than or equal to," and both end values are included.

(Oral Composition)
In this embodiment, the oral composition includes an abrasive and a binder, and has a tensile return force TF5 in a 5 mm tensile test of 10 gf or more and 50 gf or less as measured by the following method 1, a stringiness of 24 mm or more and 50 mm or less as measured by the following method 2, and a viscosity of 100 Pa s or less as measured by the following method 3.
(Method 1)
Name of device: Rheometer (e.g., CR-3000EX-S, manufactured by Sun Scientific Co., Ltd.)
Jig used: Pressure-sensitive shaft for pressure/elasticity measurement (Φ20 mm)
Measurement speed: 60mm/min
Pulling distance: 5mm
Filling container: 30mL plastic jar (diameter 43mm)
Procedure: Fill the filling container with the oral composition until it is full, set it in the device, and then lift it up at the measurement speed. Measure the absolute value of the stress when the lifting distance is reached. The average value of three measurements is taken as TF5.
In the procedure of Method 1, the numerical value of the stress during pulling is a negative value, so the recorded value is a negative value and the absolute value is a positive value.

(Method 2)
Name of device: Rheometer (e.g., CR-3000EX-S, manufactured by Sun Scientific Co., Ltd.)
Tool used: Pressure-sensitive shaft for measuring penetration (Φ15 mm)
Measurement speed: 1000mm/min
Pulling distance: 50mm
Filling container: 30mL plastic jar (diameter 43mm)
Procedure: Fill the filling container with the oral composition until it is full, set it in the device, and then pull it up at the measurement speed. Measure the distance until the oral composition separates from the jig during pulling. Measure the average of three times until the pulling distance is taken as the stringiness.

(Method 3)
Name of device: B-type viscometer, rotor No. 4 (for example, TVB-25L, manufactured by Toki Sangyo Co., Ltd.)
Measurement speed: 12 rpm, 5M range Measurement time: 60 seconds Filling container: 19 mL vial (diameter 27 mm)
Procedure: Fill the filling container to the brim with the oral composition, set it in the instrument, and then measure the viscosity at the measurement speed and for the measurement time described above.

Here, the measurement temperature in measurements 1 to 3 is specifically room temperature (25°C).

The present inventors have conducted research focusing on the ingredients and physical properties as design guidelines for improving usability when squeezing an oral composition from a tube container when the composition is filled in the tube. As a result, the inventors have newly discovered that by controlling the ingredients of the oral composition while controlling the tensile return force TF5, spinnability, and viscosity as indicators, the oral composition filled in the tube container can be easily squeezed out of the tube container and has excellent sharpness, and that a favorable balance of these can be achieved.
That is, in this embodiment, the oral composition contains a combination of an abrasive and a binder, and the tensile return force TF5, spinnability, and viscosity are each within a specific range, so that the oral composition has an excellent balance between ease of squeezing and sharpness when squeezed out of the tube container. This also makes it possible to provide an oral composition that is excellent in ease of handling. For example, it is possible to reduce the feeling of excessive hardness when squeezing the oral composition filled in the tube container out of the tube container, and to suitably reduce dripping from the discharge port. It is also possible to improve the handleability of the oral composition in the procedure from squeezing the dentifrice filled in the tube container onto a toothbrush to applying it to the oral cavity.

The tensile return force TF5 in a 5 mm tensile test measured by method 1 is 10 gf or more, preferably 10.5 gf or more, more preferably 11 gf or more, and even more preferably 11.5 gf or more. This makes it possible to obtain an oral composition that is less likely to drip when taken out onto a toothbrush. In addition, it is possible to improve the sharpness when squeezing the oral composition from a tube container.
From the same viewpoint, TF5 is 50 gf or less, preferably 40 gf or less, more preferably 30 gf or less, even more preferably 20 gf or less, and even more preferably 18 gf or less. This also makes it possible to obtain an oral composition that is easily separated from a tube container when squeezed out.

The spinnability of the oral composition measured by method 2 is 24 mm or more, preferably 27 mm or more, and more preferably 30 mm or more. This makes it possible to obtain an oral composition that is easily spread in the oral cavity.
The spinnability of the oral composition is 50 mm or less, preferably 45 mm or less, and more preferably 40 mm or less, thereby making it possible to obtain an oral composition that is less likely to cause an unpleasant feeling of stickiness when brushing teeth.

The viscosity of the oral composition measured by method 3 is 100 Pa·s or less, preferably 90 Pa·s or less, more preferably 80 Pa·s or less, even more preferably 70 Pa·s or less, and even more preferably 60 Pa·s or less, thereby making it possible to obtain an oral composition that is easy to handle when filled into a tube container.
The viscosity of the oral composition is specifically 0 Pa·s or more, preferably 10 Pa·s or more, and more preferably 20 Pa·s or more, so that an oral composition that firmly adheres to and remains on the tooth surface during brushing can be obtained.

Next, the components of the oral composition will be described.
The oral composition includes an abrasive and a binder as described above.

(Abrasive)
Examples of the abrasive include one or more selected from the group consisting of abrasive silica such as hydrous silicic acid (e.g., gel-processed silica, precipitated silica), anhydrous silicic acid, silica gel, and aluminosilicate; zeolites; calcium phosphate-based abrasives such as calcium hydrogen phosphate anhydrate, calcium hydrogen phosphate dihydrate, and calcium pyrophosphate; calcium carbonate-based abrasives such as calcium carbonate; and other inorganic abrasives such as aluminum hydroxide, alumina, magnesium carbonate, magnesium triphosphate, zirconium silicate, calcium triphosphate, hydroxyapatite, and calcium quaternary phosphate; and organic abrasives such as synthetic resin-based abrasives.

The abrasive preferably contains abrasive silica, more preferably contains hydrated silicic acid. It is also preferable that the abrasive contains anhydrous silicic acid. This makes it possible to more stably improve the balance between the ease of squeezing the product out of the tube container and the sharpness of the product.
The abrasive silica may be either crystalline silica or amorphous silica, or may be wet silica.

The average particle size of the abrasive silica is preferably 1 μm or more, more preferably 2 μm or more, even more preferably 3 μm or more, and even more preferably 5 μm or more, so that stains on the tooth surface can be efficiently removed.
The average particle size of the abrasive silica is preferably 50 μm or less, more preferably 30 μm or less, and even more preferably 20 μm or less, whereby an oral composition that is smooth to the touch can be obtained.

Here, the average particle size of the abrasive silica and the viscosity increasing silica described below can be the d ₅₀ value when the particle size distribution of the particles is measured on a volume basis using a commercially available laser diffraction/scattering type particle size distribution measuring device.

It is also preferable that the abrasive is substantially free of calcium carbonate, which makes it possible to more stably improve the balance between the ease of squeezing the product out of the tube container and the sharpness of the product.
Here, the oral composition not containing calcium carbonate specifically means that calcium carbonate is not intentionally blended into the oral composition, and more specifically means that the calcium carbonate content is 0.001 mass% or less relative to the entire oral composition.

The content of the abrasive in the oral composition is preferably 5% by mass or more, more preferably more than 5% by mass, even more preferably more than 10% by mass, still more preferably more than 10% by mass, even more preferably more than 11% by mass, and even more preferably more than 13% by mass, based on the total amount of the oral composition. This allows for efficient removal of stains on the tooth surface.
The content of the abrasive in the oral composition is preferably 30% by mass or less, more preferably less than 30% by mass, even more preferably 25% by mass or less, and even more preferably 20% by mass or less, based on the total amount of the oral composition. This makes it possible to obtain an oral composition that is excellent in smoothness when used.

(Binding Agent)
Examples of the binder include at least one selected from the group consisting of thickening silica such as hydrous silicic acid (e.g., gel-processed silica, precipitated silica) and anhydrous silicic acid (e.g., gel-processed silica, precipitated silica, dry silica); other inorganic binders such as bentonite; and organic binders such as pullulan, gelatin, methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose and salts thereof, carrageenan, alginic acid and salts thereof, xanthan gum, polyacrylic acid and salts thereof, gum arabic, guar gum, locust bean gum, polyvinyl alcohol, and carboxyvinyl polymers.
Specific examples of the above salts include alkali metal salts such as sodium salts and potassium salts.

The binder preferably contains an inorganic binder, and more preferably contains thickening silica. This makes it possible to more stably improve the balance between ease of squeezing the product out of the tube container and sharpness of the product.

The thickening silica may be either crystalline silica or amorphous silica, and may be either dry silica or wet silica.
The average particle size of the thickening silica is preferably 1 μm or more, more preferably 2 μm or more, even more preferably 5 μm or more, and even more preferably 10 μm or more, so that the viscosity of the oral composition can be more efficiently maintained.
The average particle size of the thickening silica is preferably 60 μm or less, more preferably 50 μm or less, and even more preferably 40 μm or less, whereby an oral composition that is smooth to the touch can be obtained.

The oil absorption of the thickening silica, determined by the amount of boiled linseed oil absorbed according to the method described in JIS K 5101-13-2 (2004), is, for example, 0.1 mL/g or more, preferably 0.2 mL/g or more, and, for example, 5 mL/g or less, preferably 4 mL/g or less.

The content of the inorganic binder in the oral composition is preferably 2% by mass or more, more preferably 2.5% by mass or more, even more preferably 3% by mass or more, and even more preferably 4% by mass or more, based on the total oral composition. This makes it possible to obtain an oral composition that has excellent cushioning properties when brushing teeth. This also reduces irritation caused by contact of the toothbrush with the teeth, gums, etc.
The content of the inorganic binder in the oral composition is preferably 30% by mass or less, more preferably 25% by mass or less, even more preferably 20% by mass or less, and even more preferably 15% by mass or less, based on the total amount of the oral composition, thereby making it possible to obtain an oral composition having excellent surface smoothness.

The binder preferably contains an organic binder. When the binder contains thickening silica, it is preferable that the binder further contains an organic binder. This makes it possible to more stably improve the balance between ease of squeezing when squeezing from the tube container and sharpness.

In view of the above, the organic binder preferably comprises one or more selected from the group consisting of carboxymethylcellulose and its salts (e.g., sodium carboxymethylcellulose), xanthan gum, alginic acid and its salts (e.g., sodium alginate), polyacrylic acid and its salts, carboxyvinyl polymers, hydroxyethylcellulose, hydroxypropylcellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, and carrageenan (preferably excluding κ-carrageenan, e.g., ι-carrageenan);
More preferably, it contains one or more selected from the group consisting of carrageenan, sodium alginate, sodium carboxymethylcellulose and xanthan gum;
More preferably, it contains two or more selected from the group consisting of carrageenan, sodium alginate, sodium carboxymethylcellulose, and xanthan gum;
Even more preferably, it comprises sodium alginate or sodium carboxymethylcellulose and xanthan gum;
Even more preferably, it contains sodium alginate and xanthan gum.
Specific examples of the above salts include alkali metal salts such as sodium salts and potassium salts.

On the other hand, in terms of making it easier to rinse the oral cavity, it is also preferable that the oral composition does not contain xanthan gum. Specifically, the oral composition does not contain xanthan gum means that xanthan gum is not intentionally blended into the oral composition, and more specifically, the content of xanthan gum is 0.001% by mass or less of the entire oral composition.

The content of the organic binder in the oral composition is preferably 0.2% by mass or more, more preferably 0.3% by mass or more, and even more preferably 1% by mass or more, based on the total amount of the oral composition, so that the oral composition can have an appropriate viscosity.
The content of the organic binder in the oral composition is preferably 15% by mass or less, more preferably 12% by mass or less, even more preferably 11% by mass or less, and even more preferably 10% by mass or less, based on the total oral composition, which allows the oral composition to be squeezed out smoothly from a tube container.

The mass ratio of the organic binder content to the inorganic binder content in the oral cavity composition (organic binder/inorganic binder) is preferably 0.05 or more, more preferably 0.1 or more, and even more preferably 0.2 or more, thereby making it possible to obtain an oral cavity composition that is smooth to the touch and has an excellent usability.
Moreover, the mass ratio (organic binder/inorganic binder) is preferably 2.0 or less, more preferably 1.75 or less, even more preferably 1.5 or less, even more preferably 1.25 or less, and even more preferably 0.9 or less, thereby making it possible to obtain an oral composition that is excellent in sharpness when taken out of the tube container onto a toothbrush or the like.

The total content of the binder in the oral composition is preferably 2% by mass or more, more preferably 3% by mass or more, and even more preferably 5% by mass or more, based on the total amount of the oral composition, which allows the oral composition to have an appropriate viscosity.
The total content of the binder in the oral composition is, for example, 45% by mass or less, preferably 15% by mass or less, more preferably 12% by mass or less, even more preferably 11% by mass or less, and even more preferably 10% by mass or less, based on the entire oral composition. This makes it possible to obtain an oral composition that is more easily mixed with saliva during tooth brushing. Also, excessive thickening of the oral composition can be suppressed.

The total content of silica in the oral composition is preferably 10% by mass or more, more preferably 15% by mass or more, and even more preferably 20% by mass or more, based on the total amount of the oral composition, so that the fluidity of the oral composition can be appropriately controlled.
The total content of silica in the oral composition is, for example, 60% by mass or less, preferably 30% by mass or less, more preferably 27.5% by mass or less, and even more preferably 25% by mass or less, based on the total oral composition, which allows for an oral composition that is more compatible with saliva in the oral cavity, for example, during tooth brushing.

(Other ingredients)
The oral composition may further contain ingredients other than those mentioned above, such as medicinal ingredients, thickeners, surfactants, humectants, flavoring agents, preservatives, fragrances, colorants, pH adjusters, solvents, solubilizers, bases, detergents, adsorbents, etc., which may be appropriately selected depending on the dosage form.

The medicinal components include, for example, one or more selected from the group consisting of bactericides, anti-inflammatory agents, blood circulation promoters, tartar deposition inhibitors, stain removers, dentin hypersensitivity inhibitors, vitamins, and plaque decomposing enzymes. There are no limitations on these medicinal components as long as they can be used in medicines, etc.

Among the medicinal ingredients, examples of the bactericide include one or more selected from the group consisting of isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, chlorhexidine hydrochloride, alkyldiaminoethylglycine hydrochloride, sodium lauroyl sarcosine, and triclosan.

Examples of anti-inflammatory agents include one or more selected from the group consisting of tranexamic acid, β-glycyrrhetinic acid, glycyrrhetinic acid, glycyrrhizinic acid, diammonium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, stearyl glycyrrhetinate, ε-aminocaproic acid, sodium azulene sulfonate hydrate, allantoin, allantoin dihydroxyaluminum, epidihydrocholesterol, dihydrocholesterol, and lysozyme hydrochloride.

Examples of blood circulation promoters include one or more selected from the group consisting of sodium chloride, tocopherol acetate, sodium bicarbonate, sodium hydrogen carbonate, and tocopherol nicotinate.

Examples of tartar deposition inhibitors include one or more selected from the group consisting of disodium hydrogen phosphate, disodium dihydrogen pyrophosphate, sodium pyrophosphate, anhydrous sodium pyrophosphate, tetrasodium pyrophosphate (anhydrous), disodium monohydrogen phosphate, sodium hydrogen phosphate hydrate, disodium hydrogen phosphate (crystalline), trisodium phosphate, and sodium polyphosphate.

Examples of stain removers include one or more selected from the group consisting of macrogol (Macrogol 200, Macrogol 300, Macrogol 400, Macrogol 600, Macrogol 1000, Macrogol 1500, Macrogol 1540, Macrogol 4000, Macrogol 6000, Macrogol 20000, etc.), sodium polyphosphate, and polyvinylpyrrolidone.

The dentin hypersensitivity suppressant may be, for example, at least one selected from the group consisting of potassium nitrate and water-soluble aluminum salts.

Examples of vitamin preparations include one or more selected from the group consisting of vitamin C and its derivatives, such as ascorbic acid, L-ascorbic acid, sodium ascorbate, sodium L-ascorbate, magnesium L-ascorbyl phosphate, pyridoxine hydrochloride, L-ascorbic acid 2-glucoside, ascorbyl tetra 2-hexyldecanoate, trisodium ascorbyl palmitate phosphate, 3-O-ethyl ascorbic acid, tocopherol, disodium isostearyl ascorbyl phosphate, and caprylyl 2-glyceryl ascorbate; and vitamin E and its derivatives, such as DL-α-tocopherol acetate, tocopherol acetate, dl-α-tocopherol nicotinate, and tocopherol nicotinate.

An example of a plaque-decomposing enzyme is dextranase.

Thickening agents that can be used include, for example, those commercially available as pharmaceutical, food, and cosmetic raw materials. Thickening agents include, for example, one or more selected from the group consisting of polyhydric alcohols, more specifically sorbitol (sorbitol), glycerin, concentrated glycerin, diglycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, propanediol (1,3-propanediol), polyethylene glycol, polypropylene glycol, xylitol, maltitol, lactitol, trehalose, sodium hyaluronate, and hydrolyzed collagen.

Examples of the surfactant include anionic surfactants such as N-acylamino acid salts, α-olefin sulfonates, N-acylsulfonates, alkyl sulfates (e.g., sodium lauryl sulfate), and sulfates of glycerin fatty acid esters;
Examples of the surfactant include one or more selected from the group consisting of nonionic surfactants such as polyoxyethylene alkyl ethers, polyoxyethylene-polyoxypropylene block copolymers, polyoxyethylene hydrogenated castor oil, polyoxyethylene ethers of glycerin esters, sucrose fatty acid esters, alkylolamides, and glycerin fatty acid esters; and amphoteric surfactants such as alkyl betaine surfactants (e.g., coconut oil fatty acid amide alkyl betaines), amine oxide surfactants, and imidazolinium betaine surfactants (e.g., 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine).
The surfactant may be a foaming agent.

The content of the surfactant in the oral composition is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, and even more preferably 1% by mass or more, based on the total amount of the oral composition, thereby making it possible to obtain an oral composition that foams appropriately when brushing teeth.
The content of the surfactant in the oral composition is preferably 5% by mass or less, more preferably 3% by mass or less, and even more preferably 2% by mass or less, based on the total amount of the oral composition, thereby making it possible to obtain an oral composition having a cleaning power that does not excessively remove oil from the oral cavity.

It is preferable that the oral composition further contains a humectant, which can provide the oral composition with better manufacturing stability.
The humectant may be any one that is commercially available as a pharmaceutical, food, or cosmetic ingredient, and examples thereof include polyhydric alcohols, and more specifically, one or more selected from the group consisting of sorbitol, glycerin, concentrated glycerin, diglycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, propanediol (1,3-propanediol), polyethylene glycol, polypropylene glycol, sodium hyaluronate, and hydrolyzed collagen.

In terms of reducing irritation to the oral cavity, the humectant is preferably at least one selected from the group consisting of sorbitol, concentrated glycerin, and propylene glycol, and more preferably sorbitol or concentrated glycerin.

The content of the humectant in the oral composition is preferably 5% by mass or more, more preferably 10% by mass or more, and even more preferably 20% by mass or more, based on the total amount of the oral composition, thereby making it possible to obtain an oral composition having excellent moisturizing power in the oral cavity.
The content of the humectant in the oral composition is preferably 50% by mass or less, more preferably 45% by mass or less, and even more preferably 40% by mass or less, based on the total oral composition. This makes it possible to obtain an oral composition that is easy to rinse with gargle.

Examples of flavoring agents include one or more selected from the group consisting of L-sodium glutamate, saccharin, saccharin sodium, sucrose, glucose, fructose, lactose, honey, aspartame, stevia, sucralose, inositol, D-sorbitol, D-mannitol, arabitol, raffinose, lactulose, lactitol, xylitol, erythritol, reduced palatinose, palatinose, Palatinit (registered trademark), acesulfame K, trehalose, maltose, maltosyl trehalose or maltitol, neohesperidin dihydrochalcone, perillartine, p-methoxycinnamic aldehyde, and thaumatin.

The flavoring agent is preferably at least one selected from the group consisting of xylitol, sodium saccharin, and saccharin, and more preferably at least one selected from the group consisting of xylitol and sodium saccharin, because it has a strong sweetness and can be used to adjust the taste even in small amounts.

Examples of preservatives include one or more selected from the group consisting of paraoxybenzoic acid esters such as sodium benzoate, methylparaben, ethylparaben, butylparaben, isopropylparaben, propylparaben, isobutylparaben, and benzylparaben; alcohols such as phenoxyethanol; sorbic acid, benzoic acid, dehydroacetic acid, propionic acid, and salts thereof; ethylenediaminetetraacetate, alkyldiaminoethylglycine hydrochloride, and ethylhexylglycerin.
Specific examples of the above salts include alkali metal salts such as sodium salts and potassium salts; and alkaline earth metal salts such as calcium salts and magnesium salts.

The flavoring may be, for example, one or more selected from the group consisting of L-menthol, peppermint, spearmint, fruit flavorings, and peppermint oil.

Coloring agents include, for example, one or more of the following natural dyes: safflower red, gardenia yellow, gardenia blue, perilla, red koji, red cabbage, carrot, hibiscus, cacao, spirulina blue, coumarind; legal dyes: Red No. 3, Red No. 104, Red No. 105, Red No. 106, Yellow No. 4, Yellow No. 5, Green No. 3, Blue No. 1; riboflavin, and titanium dioxide.

Examples of pH adjusters include one or more selected from the group consisting of acids, alkalis, and buffers, such as acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, phosphoric acid, malic acid, gluconic acid, maleic acid, succinic acid, glutamic acid, pyrophosphoric acid, tartaric acid, acetic acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, sodium citrate, sodium hydrogen citrate, phosphoric acid, sodium phosphate, sodium monohydrogen phosphate, sodium dihydrogen phosphate, and potassium dihydrogen phosphate.

Solvents include water; and lower alcohols such as ethanol and propanol. The solvent may be a liquid base.

The content of water in the oral composition may be, for example, the remainder after removing components other than water from the oral composition. The content of water in the oral composition may be, for example, 30 to 80% by mass, and preferably 32 to 70% by mass, based on the total mass of the oral composition.
It is also preferable that the oral composition does not contain ethanol, i.e., the ethanol content is 0% by mass, or the oral composition contains ethanol but the ethanol content is 5% by mass or less, which can suppress strong irritation to the oral cavity.

A solubilizer may be added to promote the dissolution of the additives and medicinal ingredients in water. Examples of such solubilizers include polyhydric alcohols such as dipropylene glycol.

Other bases include sodium bicarbonate.

An example of a cleaning agent is sodium polyphosphate.

An example of an adsorbent is β-cyclodextrin.

In addition to the above ingredients, ingredients that are generally suitable for use in oral compositions can also be added as appropriate, provided that they do not impair the content of the present invention.

(Dosage form, etc.)
Specific examples of oral compositions include dentifrices such as toothpaste.
In addition, the oral composition is preferably a dentifrice composition, more preferably a toothpaste composition, which can further improve the ease of handling of the oral composition. From the same viewpoint, the oral composition is preferably in a paste or gel form.

The oral composition is preferably applied to the oral cavity by being placed on a toothbrush.
The toothbrush to be used with the oral composition may be, for example, a known one.
The toothbrush to be used with the oral composition may be a typical commercially available toothbrush.

(Production method)
In this embodiment, the oral composition includes a step of blending, for example, an abrasive, a binder, and other ingredients as appropriate.
Here, in order to obtain an oral composition having TF5, spinnability and viscosity each falling within a specific range, it is important to appropriately select, for example, the components and blending ratios contained in the oral composition, as well as to appropriately select the manufacturing process for the oral composition.
For example, it is important to appropriately select and combine the types and amounts of abrasives and binders contained in the oral composition to design the composition, and it is preferable to use a combination of abrasive silica and an inorganic binder, and more preferable to use a combination of abrasive silica and a thickening silica. It is also preferable to further add an organic binder to the oral composition. It is also preferable to further add a humectant to the oral composition.
It is also preferable to carry out the manufacturing process of the oral composition under vacuum. For example, when the oral composition contains thickening silica, an organic binder, a humectant, and water, it is preferable to add thickening silica, an abrasive, and other components as appropriate during or after mixing the humectant, the organic binder, and the water, and stir and mix until uniform. It is also preferable to prepare a mixture of a part of the humectant and the organic binder in advance, add the mixture at the stage where the mixture is homogenized, and stir until further homogenized. It is more preferable to carry out these steps under vacuum.

(Dentifrice)
In this embodiment, the dentifrice is the above-mentioned oral composition filled in a tube container, and preferably is a toothpaste composition filled in a tube container.
In this embodiment, the oral composition has an excellent balance between ease of squeezing and sharpness when squeezed out of a tube container, and by filling this into a tube container to make a dentifrice, the dentifrice can be squeezed from the tube container onto a toothbrush with excellent ease of handling when applied to the oral cavity.

Oral compositions such as toothpaste compositions are preferably used by squeezing them out of a tube container. As the tube container, for example, a known container can be used.
The material of the tube container may be one or more selected from the group consisting of resin materials such as polyethylene, polypropylene, polyethylene terephthalate, nylon, etc., and metal materials such as aluminum, etc. For example, the tube container may be a single-layer or multi-layer container made of these materials.
The material of the innermost layer of the container is preferably one or more selected from the group consisting of polyethylene, polypropylene, and polyethylene terephthalate. For example, an aluminum laminated tube container may be used in which the material of the innermost layer of the container is polyethylene and further includes an aluminum layer.

The inner diameter of the discharge port of the tube container is preferably 1 mm or more, more preferably 2 mm or more, and further preferably 3 mm or more, so that the excessive force required to discharge the oral composition can be more stably reduced.
The inner diameter of the discharge port of the tube container is preferably 11 mm or less, more preferably 10 mm or less, and further preferably 9 mm or less, so that dripping can be efficiently suppressed.
The length of the tube container excluding the discharge port may be about 50 to 160 mm, and the outer circumferential length in the width direction of the tube container may be about 20 to 120 mm.

The above describes embodiments of the present invention, but these are merely examples of the present invention, and various configurations other than those described above can also be adopted.

The present embodiment will be specifically described below with examples and comparative examples, but the present embodiment is not limited to these examples.

(Examples 1 to 3, Comparative Examples 1 to 3)
In this example, oral compositions, which are toothpaste compositions, were prepared and evaluated. The formulation, measurement and evaluation results of each example are shown in Table 1. The unit of component amount in Table 1 is mass %, and the particle size of silica is the average particle size. Details of the components listed in Table 1 are shown below.
Sorbitol Kao: 70% sorbitol solution, Kao Co., Ltd. Cosmetic concentrated glycerin: concentrated glycerin, Sakamoto Yakuhin Kogyo Co., Ltd. CEKOL 30000: CMC-Na, CP KELCO Co., Ltd. Sodium alginate SHG: sodium alginate, Maikon no Kohara Co., Ltd. NIKKOL SLS: sodium lauryl sulfate, Nikko Chemicals Co., Ltd. Caustic soda (48%): sodium hydroxide solution, Tatsumi Synthetic Chemicals Co., Ltd.

(Preparation of oral composition)
Sorbitol or glycerin and purified water were weighed into a beaker, and the organic binder was gradually added while stirring at 2500 rpm at 80° C. using an emulsifying and dispersing device (Labo-lution, manufactured by Primix) and a stirring section (Homodisper 2.5 type, manufactured by Primix). After stirring and mixing for 3 minutes, abrasive silica, thickening silica (oil absorption 2.5 mL/g), sodium lauryl sulfate, and caustic soda were added in that order, stirring and mixing with a rubber spatula each time, until the mixture was uniform.

(Tensile return force)
TF5 was measured at 25°C by the method 1 described above.
Device name: Rheometer (CR-3000EX-S, manufactured by Sun Scientific Co., Ltd., detection limit: 0.1 gf)
Jig used: Pressure/elasticity measuring pressure-sensitive shaft (Φ20 mm)
Measurement speed: 60mm/min
Pull-up distance: 5mm or 10mm
Filling container: 30mL plastic jar (diameter 43mm)
The absolute value of the stress at the time when the pulling distance was reached was measured three times at the pulling distance, and the average value was calculated and designated as TF5. Although the measured value was a negative value, the absolute value (positive value) was used to compare the magnitude of the force.

(Spinnability)
This was carried out at 25°C according to Method 2 above.
Device name: Rheometer (CR-3000EX-S, manufactured by Sun Scientific Co., Ltd.)
Tool used: Pressure-sensitive shaft for measuring penetration (Φ15 mm)
Measurement speed: 1000mm/min
Pulling distance: 50mm
Filling container: 30mL plastic jar (diameter 43mm)
The distance by which the toothpaste composition was separated from the jig during the pulling process was measured three times, and the average value was calculated.

(viscosity)
This was carried out at 25°C according to Method 3 above.
Equipment name: B-type viscometer, rotor No. 4 (Toki Sangyo Co., Ltd., TVB-25L)
Measurement speed: 12 rpm, 5M range Measurement time: 60 seconds Filling container: 19 mL vial (diameter 27 mm)
Procedure: A filling container was filled to the brim with the toothpaste composition, and after setting it in the instrument, the viscosity was measured at the measurement speed and for the measurement time described above.

(Evaluation Method)
(Easy to squeeze out)
The ease of squeezing each toothpaste composition from a tube container was evaluated by the following method.
Each toothpaste composition was filled into a laminate tube (manufactured by Takemoto Container Co., Ltd.) made of low density polyethylene (LDPE) with a diameter of 19 mm and a size of 40Φ×130H. A one-touch cap (T-40Φ one-touch CAPII, manufactured by Takemoto Container Co., Ltd.) made of polypropylene with a diameter of 6 mm and a size of 39Φ×24H was attached as a cap, and this was placed on a balance (MSU6202S-100-D0, manufactured by Sartorius) at room temperature (25° C.), and the magnitude of force (g) required to press the center of the tube container 1 cm with the pads of the index finger and middle finger in about 1 second to discharge the container was measured. A force in the range of 500 g or more and less than 3000 g was judged to be acceptable (preferably 500 g or more and less than 2500 g).

(Sharpness)
The toothpaste composition of each example was filled into a laminate tube made of low density polyethylene (LDPE) with a diameter of 19 mm and a size of 40Φ×130H (manufactured by Takemoto Container Co., Ltd.). A one-touch cap made of polypropylene with a diameter of 6 mm and a size of 39Φ×24H (T-40Φ one-touch CAP II, manufactured by Takemoto Container Co., Ltd.) was attached, and the toothpaste composition was extruded from the tube for about 2.5 cm onto a paper towel. The tube was then pulled sideways at a speed of about 5 cm per second, and the length of the string of the composition was measured and evaluated according to the following evaluation criteria.
A: The length of the stringy composition is less than 20 mm. B: The length of the stringy composition is 20 mm or more and less than 28 mm. C: The length of the stringy composition is 28 mm or more.

Claims (9)

An oral composition comprising an abrasive , a binder and a humectant ,
the abrasive comprises abrasive silica;
The binder comprises at least one selected from the group consisting of xanthan gum, sodium alginate, and thickening silica;
the humectant comprises sorbitol;
The tensile return force TF5 in a 5 mm tensile test measured by the following method 1 is 10 gf or more and 50 gf or less,
The spinnability measured by the following method 2 is 24 mm or more and 50 mm or less,
An oral composition having a viscosity of 100 Pa·s or less as measured by the following method 3.
(Method 1)
Name of equipment: Rheometer Jig used: Pressure-sensitive shaft for pressure/elasticity measurement (Φ20 mm)
Measurement speed: 60mm/min
Pulling distance: 5mm
Filling container: 30mL plastic jar (diameter 43mm)
Procedure: The filling container is filled to the brim with the oral composition, and after setting it in the device, it is pulled up at the measurement speed, and the absolute value of the stress at the time when the pulling distance is reached is measured. The average value of three measurements is defined as the TF5.
(Method 2)
Name of equipment: Rheometer Jig used: Pressure-sensitive shaft for measuring penetration (Φ15 mm)
Measurement speed: 1000mm/min
Pulling distance: 50mm
Filling container: 30mL plastic jar (diameter 43mm)
Procedure: The oral composition is filled into the filling container until it is fully filled, and then the container is set in the device and then pulled up at the measurement speed. The distance until the oral composition separates from the jig during pulling is measured. The average value of the distance that is measured three times is regarded as the spinnability.
(Method 3)
Equipment name: B-type viscometer, rotor No. 4
Measurement speed: 12 rpm, 5M range Measurement time: 60 seconds Filling container: 19 mL vial (diameter 27 mm)
Procedure: The oral composition is filled into the filling container until it is fully filled, and after setting it in the instrument, the viscosity is measured at the measurement speed and for the measurement time. The oral composition according to claim 1 , wherein the content of the binder in the oral composition is 2% by mass or more and 45% by mass or less based on the total amount of the oral composition. The oral composition according to claim 1 or 2, wherein the binder comprises an organic binder. The oral composition according to claim 3, wherein the content of the organic binder in the oral composition is 0.2% by mass or more and 15% by mass or less based on the total mass of the oral composition. 3. The oral composition according to claim 1, wherein the content of the abrasive in the oral composition is 5% by mass or more and 30% by mass or less based on the total oral composition. 3. The oral composition according to claim 1 , wherein the content of the humectant in the oral composition is 5% by mass or more and 50% by mass or less based on the total oral composition. The oral composition according to claim 1 or 2, which is a dentifrice composition. The oral composition according to claim 1 or 2, which is a toothpaste composition. A dentifrice in which the oral composition according to claim 8 is packed in a tube container.