JPH04504056A - 鳥類への異種遺伝子の導入 - Google Patents
鳥類への異種遺伝子の導入Info
- Publication number
- JPH04504056A JPH04504056A JP2504969A JP50496990A JPH04504056A JP H04504056 A JPH04504056 A JP H04504056A JP 2504969 A JP2504969 A JP 2504969A JP 50496990 A JP50496990 A JP 50496990A JP H04504056 A JPH04504056 A JP H04504056A
- Authority
- JP
- Japan
- Prior art keywords
- primordial germ
- cells
- embryo
- foreign nucleic
- germ cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000623 proteins and genes Proteins 0.000 title claims description 31
- 210000004602 germ cell Anatomy 0.000 claims description 60
- 238000000034 method Methods 0.000 claims description 60
- 210000001161 mammalian embryo Anatomy 0.000 claims description 51
- 108020004707 nucleic acids Proteins 0.000 claims description 38
- 102000039446 nucleic acids Human genes 0.000 claims description 38
- 150000007523 nucleic acids Chemical class 0.000 claims description 38
- 210000004027 cell Anatomy 0.000 claims description 37
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- 239000013598 vector Substances 0.000 claims description 28
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- 238000000338 in vitro Methods 0.000 claims description 17
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 4
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- OALHHIHQOFIMEF-UHFFFAOYSA-N 3',6'-dihydroxy-2',4',5',7'-tetraiodo-3h-spiro[2-benzofuran-1,9'-xanthene]-3-one Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC(I)=C(O)C(I)=C1OC1=C(I)C(O)=C(I)C=C21 OALHHIHQOFIMEF-UHFFFAOYSA-N 0.000 description 2
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- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
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- 101150066555 lacZ gene Proteins 0.000 description 2
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- 229920001220 nitrocellulos Polymers 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 210000000287 oocyte Anatomy 0.000 description 2
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- 210000002845 virion Anatomy 0.000 description 2
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 208000009663 Acute Necrotizing Pancreatitis Diseases 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 241000272517 Anseriformes Species 0.000 description 1
- 241000272473 Aquila chrysaetos Species 0.000 description 1
- 241000711404 Avian avulavirus 1 Species 0.000 description 1
- 241000714230 Avian leukemia virus Species 0.000 description 1
- 241000714235 Avian retrovirus Species 0.000 description 1
- COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 241000282994 Cervidae Species 0.000 description 1
- 208000003495 Coccidiosis Diseases 0.000 description 1
- 241000219122 Cucurbita Species 0.000 description 1
- 235000009852 Cucurbita pepo Nutrition 0.000 description 1
- 108020003215 DNA Probes Proteins 0.000 description 1
- 239000003298 DNA probe Substances 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 102000002464 Galactosidases Human genes 0.000 description 1
- 108010093031 Galactosidases Proteins 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 206010023076 Isosporiasis Diseases 0.000 description 1
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- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 206010058096 Pancreatic necrosis Diseases 0.000 description 1
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- 208000027954 Poultry disease Diseases 0.000 description 1
- 206010058824 Pulmonary necrosis Diseases 0.000 description 1
- 241000220010 Rhode Species 0.000 description 1
- 241001138501 Salmonella enterica Species 0.000 description 1
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- 244000062793 Sorghum vulgare Species 0.000 description 1
- 238000002105 Southern blotting Methods 0.000 description 1
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- 102000004142 Trypsin Human genes 0.000 description 1
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- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 235000021028 berry Nutrition 0.000 description 1
- 210000004952 blastocoel Anatomy 0.000 description 1
- 210000002459 blastocyst Anatomy 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 229960002092 busulfan Drugs 0.000 description 1
- 238000012754 cardiac puncture Methods 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
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- 235000013330 chicken meat Nutrition 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- QTCANKDTWWSCMR-UHFFFAOYSA-N costic aldehyde Natural products C1CCC(=C)C2CC(C(=C)C=O)CCC21C QTCANKDTWWSCMR-UHFFFAOYSA-N 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 210000003278 egg shell Anatomy 0.000 description 1
- 108700004025 env Genes Proteins 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
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- 150000004820 halides Chemical class 0.000 description 1
- 235000015220 hamburgers Nutrition 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
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- 230000010354 integration Effects 0.000 description 1
- ISTFUJWTQAMRGA-UHFFFAOYSA-N iso-beta-costal Natural products C1C(C(=C)C=O)CCC2(C)CCCC(C)=C21 ISTFUJWTQAMRGA-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
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- 210000003716 mesoderm Anatomy 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
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- 210000004940 nucleus Anatomy 0.000 description 1
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- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
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- 102000004196 processed proteins & peptides Human genes 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Environmental Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8906214.5 | 1989-03-17 | ||
| GB898906214A GB8906214D0 (en) | 1989-03-17 | 1989-03-17 | Introducing an exogenous gene into birds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH04504056A true JPH04504056A (ja) | 1992-07-23 |
Family
ID=10653554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2504969A Pending JPH04504056A (ja) | 1989-03-17 | 1990-03-15 | 鳥類への異種遺伝子の導入 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0463047A1 (fr) |
| JP (1) | JPH04504056A (fr) |
| AU (1) | AU648502B2 (fr) |
| CA (1) | CA2050925A1 (fr) |
| GB (2) | GB8906214D0 (fr) |
| WO (1) | WO1990011355A1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002543814A (ja) * | 1999-05-13 | 2002-12-24 | セダーシナイ メディカル センター | トランスジェニック種の発生と遺伝子療法用の雄性生殖細胞の遺伝的修飾法 |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4726771A (en) * | 1986-02-07 | 1988-02-23 | Weinblatt Lee S | Flat switch insertable into a magazine and usable as part of a survey technique for readership of publications |
| JP2535792B2 (ja) * | 1994-10-31 | 1996-09-18 | 農林水産省畜産試験場長 | 始原生殖細胞および生殖細胞の凍結保存法 |
| AU8817798A (en) * | 1997-08-22 | 1999-03-16 | Biotechnology And Biological Sciences Research Council, The | Use of (mariner) transposan in the production of transgenic animals |
| US7511120B2 (en) | 1997-10-16 | 2009-03-31 | Synageva Biopharma Corp. | Glycosylated G-CSF obtained from a transgenic chicken |
| EP2133421A1 (fr) | 1997-10-16 | 2009-12-16 | University Of Georgia Research Foundation, Inc. | Oiseaux transgéniques et production de protéines dans l'albumen des oeufs |
| US20040019923A1 (en) | 1997-10-16 | 2004-01-29 | Ivarie Robert D. | Exogenous proteins expressed in avians and their eggs |
| US7129390B2 (en) | 1997-10-16 | 2006-10-31 | Avigenics, Inc | Poultry Derived Glycosylated Interferon Alpha 2b |
| US8563803B2 (en) | 1997-10-16 | 2013-10-22 | Synageva Biopharma Corp. | Method of making protein in an egg of a transgenic chicken |
| KR20010033162A (ko) * | 1998-01-28 | 2001-04-25 | 오미야 히사시 | 생식세포로의 유전자 도입법 |
| US7049480B1 (en) | 2000-09-01 | 2006-05-23 | Avigenics, Inc. | Methods of enucleating an avian oocyte or zygote using two-photon laser scanning microscopy |
| US7339090B2 (en) | 2001-02-13 | 2008-03-04 | Avigenics, Inc. | Microinjection devices and methods of use |
| EP1361788A2 (fr) * | 2001-02-16 | 2003-11-19 | Tranxenogen, Inc. | Production d'une lignee germinale d'oiseaux fondee sur une cellule germinale primordiale |
| US7550650B2 (en) | 2001-09-18 | 2009-06-23 | Synageva Biopharma Corp. | Production of a transgenic avian by cytoplasmic injection |
| ATE513038T1 (de) | 2001-09-18 | 2011-07-15 | Synageva Biopharma Corp | Produktion eines transgenen vogels mittels cytoplasmainjektion |
| US7117814B2 (en) * | 2001-09-26 | 2006-10-10 | Ovagen International Limited | Method of producing avian eggs and birds of germ-free status |
| US7803362B2 (en) | 2003-01-24 | 2010-09-28 | Synageva Biopharma Corp. | Glycosylated interferon alpha |
| US7381712B2 (en) | 2003-05-09 | 2008-06-03 | Avigenics, Inc. | In vivo transfection in avians |
| US20080222744A1 (en) | 2003-05-09 | 2008-09-11 | Avigenics, Inc. | In vivo transfection in avians |
| US20050090001A1 (en) | 2003-10-07 | 2005-04-28 | Parker Stephen H. | Cell lines and methods for producing proteins |
| US8124732B2 (en) | 2005-06-24 | 2012-02-28 | Synageva Biopharma Corp. | Composition comprising isolated human CTLA4-Fc fusion protein produced in a transgenic chicken |
| US7812127B2 (en) | 2006-03-17 | 2010-10-12 | Synageva Biopharma Corp. | Glycosylated human G-CSF |
| AU2013204327B2 (en) | 2012-04-20 | 2016-09-01 | Aviagen | Cell transfection method |
| WO2016091272A1 (fr) * | 2014-12-12 | 2016-06-16 | Central Veterinary Research Laboratory | Système et procédé pour l'établissement d'une culture à long terme de cellules germinales primordiales aviaires et utilisations associées |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5162215A (en) * | 1988-09-22 | 1992-11-10 | Amgen Inc. | Method of gene transfer into chickens and other avian species |
| GB8823869D0 (en) * | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
-
1989
- 1989-03-17 GB GB898906214A patent/GB8906214D0/en active Pending
-
1990
- 1990-03-15 GB GB9005883A patent/GB2229440A/en not_active Withdrawn
- 1990-03-15 EP EP19900904874 patent/EP0463047A1/fr not_active Withdrawn
- 1990-03-15 JP JP2504969A patent/JPH04504056A/ja active Pending
- 1990-03-15 CA CA 2050925 patent/CA2050925A1/fr not_active Abandoned
- 1990-03-15 AU AU52879/90A patent/AU648502B2/en not_active Ceased
- 1990-03-15 WO PCT/GB1990/000388 patent/WO1990011355A1/fr not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002543814A (ja) * | 1999-05-13 | 2002-12-24 | セダーシナイ メディカル センター | トランスジェニック種の発生と遺伝子療法用の雄性生殖細胞の遺伝的修飾法 |
Also Published As
| Publication number | Publication date |
|---|---|
| GB8906214D0 (en) | 1989-05-04 |
| AU648502B2 (en) | 1994-04-28 |
| CA2050925A1 (fr) | 1990-09-18 |
| AU5287990A (en) | 1990-10-22 |
| WO1990011355A1 (fr) | 1990-10-04 |
| GB9005883D0 (en) | 1990-05-09 |
| EP0463047A1 (fr) | 1992-01-02 |
| GB2229440A (en) | 1990-09-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
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